Semisynthetic broad-spectrum cephalosporin.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Non-susceptibility of an organism to the action of the cephalosporins.
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Substances that reduce the growth or reproduction of BACTERIA.
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Nonsusceptibility of an organism to the action of penicillins.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Infections with bacteria of the family ENTEROBACTERIACEAE.
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.
Infections with bacteria of the genus KLEBSIELLA.
A semisynthetic ampicillin-derived acylureido penicillin.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Infections by bacteria, general or unspecified.
Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.
One of the principal schools of medical philosophy in ancient Greece and Rome. It developed in Alexandria between 270 and 220 B.C., the only one to have any success in reviving the essentials of the Hippocratic concept. The Empiricists declared that the search for ultimate causes of phenomena was vain, but they were active in endeavoring to discover immediate causes. The "tripod of the Empirics" was their own chance observations (experience), learning obtained from contemporaries and predecessors (experience of others), and, in the case of new diseases, the formation of conclusions from other diseases which they resembled (analogy). Empiricism enjoyed sporadic continuing popularity in later centuries up to the nineteenth. (From Castiglioni, A History of Medicine, 2d ed, p186; Dr. James H. Cassedy, NLM History of Medicine Division)
Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.
Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.
Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.

Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin. (1/764)

AIMS: The aim of this study was to determine the potential influence of variables such as the cell content in the fluid, and serum levels, on the concentrations of ceftibuten, cefixime and azithromycin in the middle ear fluid of patients suffering from acute otitis media. METHODS: This randomized, open study compared the penetration of ceftibuten (9 mg kg(-1) 18 patients), cefixime (8 mg kg(-1), 16 patients) and azithromycin (10 mg kg(-1) 16 patients) into the intracellular and extracellular compartments of middle ear fluid of 50 paediatric patients (aged 8-14 years) with acute otitis media. Middle ear fluid was extracted by tympanocentesis 4, 12 and 24 h after dosing and divided into two fractions: with cells (as collected) (C+) and cell-free (C-). Antibiotics were assayed in C+ and C- samples by h.p.l.c. RESULTS: Ceftibuten achieved greater penetration into middle ear fluid than cefixime and azithromycin. Higher concentrations of ceftibuten (CTB) and cefixime (CFX) were found in the C- fraction (CTB: 4h 13.3+/-1.86; 12h 4.7+/-1.18; 24h 0.5+/-0.2. CFX: 4h 3.2+/-1.4; 12h 1.5+/-0.5; 24h>(0.1 mgl(-1)) than in the C+ fraction (CTB:4 h 8.4+/-4.3; 12 h 2.88+/-1.19; 24 h 0.3+/-0.27. CFX: 4 h 1.2+/-0.6; 12 h 0.8+/-0.2; 24 h>0.1 mg l(-1)) at the each time point, while the opposite was true for azithromycin (C-: 4 h 0.11+/-0.04; 12 h 0.12+/-0.08; 24 h 0.23+/-0.12. C+: 4 h 0.38+/-0.24; 12 h 0.9+/-0.03; 24 h 1.05+/-0.3 mg l(-1)). CONCLUSIONS: This study demonstrates that the penetration of antibiotics into the middle ear fluid is influenced by its serum concentrations as well as by the cell content in the fluid. Ceftibuten achieved higher middle ear fluid concentrations than cefixime in C+ and C- fractions at all time points. Both ceftibuten and cefixime concentrations are negatively influenced by the cell content in the fluid. In contrast the concentration of azithromycin to the middle ear fluid is positively influenced by the cell content in the fluid.  (+info)

Glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae is membrane associated. (2/764)

Penicillin-binding proteins (PBPs) are bacterial cytoplasmic membrane proteins that catalyze the final steps of the peptidoglycan synthesis. Resistance to beta-lactams in Streptococcus pneumoniae is caused by low-affinity PBPs. S. pneumoniae PBP 2a belongs to the class A high-molecular-mass PBPs having both glycosyltransferase (GT) and transpeptide (TP) activities. Structural and functional studies of both domains are required to unravel the mechanisms of resistance, a prerequisite for the development of novel antibiotics. The extracellular region of S. pneumoniae PBP 2a has been expressed (PBP 2a*) in Escherichia coli as a glutathione S-transferase fusion protein. The acylation kinetic parameters of PBP 2a* for beta-lactams were determined by stopped-flow fluorometry. The acylation efficiency toward benzylpenicillin was much lower than that toward cefotaxime, a result suggesting that PBP 2a participates in resistance to cefotaxime and other beta-lactams, but not in resistance to benzylpenicillin. The TP domain was purified following limited proteolysis. PBP 2a* required detergents for solubility and interacted with lipid vesicles, while the TP domain was water soluble. We propose that PBP 2a* interacts with the cytoplasmic membrane in a region distinct from its transmembrane anchor region, which is located between Lys 78 and Ser 156 of the GT domain.  (+info)

Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery. (3/764)

To determine the efficacy and safety of single-dose oral ciprofloxacin prophylaxis for the prevention of post-operative bacteriuria following transurethral resection of the prostate or bladder tumour, a prospective, randomized, double-blind, placebo-controlled trial was conducted. Five hundred and eighteen patients were randomized in a 2:2:1 ratio to receive ciprofloxacin 500 mg, cefotaxime 1 g or placebo 30-90 min before surgery. Of the 368 efficacy-evaluable patients, five (3.3%) ciprofloxacin, seven (4.8%) cefotaxime and five (7.0%) placebo recipients had post-operative bacteriuria (> or = 10(4) cfu/mL) during post-operative days 2-15. Five (3.4%) ciprofloxacin, five (3.4%) cefotaxime and one (2.4%) placebo recipients were considered clinical failures, of whom one, two and one patients, respectively, had concomitant bacteriuria. Drug-related adverse events were reported in six of 204 (3%) ciprofloxacin, 12 of 197 (6%) cefotaxime and one of 101 (1%) placebo patients. The observed rates of post-operative bacteriuria suggest that a single 500 mg dose of ciprofloxacin is suitable prophylaxis for transurethral surgery.  (+info)

Dissemination of a chloramphenicol- and tetracycline-resistant but penicillin-susceptible invasive clone of serotype 5 Streptococcus pneumoniae in Colombia. (4/764)

A national surveillance conducted in Colombia between 1994 and 1996 identified serotype 5 Streptococcus pneumoniae as the second most frequent cause of invasive disease in children younger than 5 years of age. All 43 serotype 5 isolates collected during this period were shown to be susceptible to penicillin, erythromycin, cefotaxime, and vancomycin, but most (38 of 43, or 88%) were highly resistant to chloramphenicol. In order to clarify a possible genetic relatedness among these isolates, additional microbiological and molecular characterizations were performed. Most (40 of 43, or 93%) of the isolates were found to be resistant to tetracycline. Pulsed-field gel electrophoresis (PFGE) patterns of chromosomal DNAs revealed that all the 43 isolates were closely related and that 38 of the 43 isolates were representatives of a "Colombian clone" of S. pneumoniae isolates which were recovered throughout the 3-year surveillance period from patients in 13 hospitals located in five Colombian cities. Isolates belonging to this Colombian clone were resistant to chloramphenicol and tetracycline, hybridized with the cat and tetM DNA probes in the same 340-kb SmaI fragment, and had identical PFGE patterns after both SmaI and ApaI digestions.  (+info)

In-vitro activity of 29 antimicrobial agents against penicillin-resistant and -intermediate isolates of Streptococcus pneumoniae. (5/764)

Antibiotic resistance among isolates of Streptococcus pneumoniae is increasing worldwide. Optimal therapy, though unknown, should be guided by in-vitro susceptibility testing. Currently, vancomycin is the only approved antibiotic that is universally active against multiresistant S. pneumoniae. In-vitro activities were determined for 29 antimicrobial agents against 22 penicillin-intermediate S. pneumoniae (PISP) and 16 penicillin-resistant S. pneumoniae (PRSP) isolates. MICs were determined in cation-adjusted Mueller-Hinton broth with 3% lysed horse blood in microtitre trays. Antimicrobial classes tested included cephalosporins, penicillin, aminopenicillins, macrolides, quinolones, carbapenems and other antimicrobial agents. Among the classes of antimicrobial agents tested, wide differences in susceptibility were demonstrated for both PISP and PRSP. Of the cephalosporins, ceftriaxone and cefotaxime demonstrated the best in-vitro activity for both PISP and PRSP. Of the quinolones, clinafloxacin and trovafloxacin showed the greatest in-vitro activity. Rifampicin and teicoplanin demonstrated excellent in-vitro activity. Promising in-vitro results of newer agents, such as quinupristin/dalfopristin, ramoplanin, teicoplanin and linezolid may justify further evaluation of these agents in clinical trials.  (+info)

Serum bactericidal activity of levofloxacin against Streptococcus pneumoniae. (6/764)

The objective of this study was to determine the serum bactericidal activity (SBA) of levofloxacin against Streptococcus pneumoniae strains with various degrees of susceptibility to penicillin and cefotaxime. Serum samples of volunteers (n = 12) who had received levofloxacin 500 mg as a single po dose were provided in blinded fashion. SBA was determined, using the microdilution method, in Todd-Hewitt broth supplemented with lysed horse blood inoculated with an overnight culture diluted to yield a final concentration of approximately 10(5) cfu/mL. The serum bactericidal titre was defined as the highest dilution of serum showing no growth (> 99.9% reduction of inoculum). The duration of SBA ranged from 0.75 to 6.3 h (mean 3.85 h), and was independent of the susceptibility of the strains to penicillin and cefotaxime. In conclusion, a single po dose of 500 mg levofloxacin achieved serum concentrations which were bactericidal against penicillin-resistant S. pneumoniae for a mean period of 3.85 h.  (+info)

Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. (7/764)

BACKGROUND: In patients with cirrhosis and spontaneous bacterial peritonitis, renal function frequently becomes impaired. This impairment is probably related to a reduction in effective arterial blood volume and is associated with a high mortality rate. We conducted a study to determine whether plasma volume expansion with intravenous albumin prevents renal impairment and reduces mortality in these patients. METHODS: We randomly assigned 126 patients with cirrhosis and spontaneous bacterial peritonitis to treatment with intravenous cefotaxime (63 patients) or cefotaxime and intravenous albumin (63 patients). Cefotaxime was given daily in dosages that varied according to the serum creatinine level, and albumin was given at a dose of 1.5 g per kilogram of body weight at the time of diagnosis, followed by 1 g per kilogram on day 3. Renal impairment was defined as nonreversible deterioration of renal function during hospitalization. RESULTS: The infection resolved in 59 patients in the cefotaxime group (94 percent) and 62 in the cefotaxime-plus-albumin group (98 percent) (P=0.36). Renal impairment developed in 21 patients in the cefotaxime group (33 percent) and 6 in the cefotaxime-plus-albumin group (10 percent) (P=0.002). Eighteen patients (29 percent) in the cefotaxime group died in the hospital, as compared with 6 (10 percent) in the cefotaxime-plus-albumin group (P=0.01); at three months, the mortality rates were 41 percent (a total of 26 deaths) and 22 percent (a total of 14 deaths), respectively (P=0.03). Patients treated with cefotaxime had higher levels of plasma renin activity than those treated with cefotaxime and albumin; patients with renal impairment had the highest values. CONCLUSIONS: In patients with cirrhosis and spontaneous bacterial peritonitis, treatment with intravenous albumin in addition to an antibiotic reduces the incidence of renal impairment and death in comparison with treatment with an antibiotic alone.  (+info)

Reduction in the incidence of methicillin-resistant Staphylococcus aureus and ceftazidime-resistant Klebsiella pneumoniae following changes in a hospital antibiotic formulary. (8/764)

In 1995, changes in our hospital formulary were made to limit an outbreak of vancomycin-resistant enterococci and resulted in decreased usage of cephalosporins, imipenem, clindamycin, and vancomycin and increased usage of beta-lactam/beta-lactamase-inhibitor antibiotics. In this report, the effect of this formulary change on other resistant pathogens is described. Following the formulary change, there was a reduction in the monthly number (mean +/- SD) of patients with methicillin-resistant Staphylococcus aureus (from 21.9 +/- 8.1 to 17.2 +/- 7.2 patients/1,000 discharges; P = .03) and ceftazidime-resistant Klebsiella pneumoniae (from 8.6 +/- 4.3 to 5.7 +/- 4.0 patients/1,000 discharges; P = .02). However, there was an increase in the number of patients with cultures positive for cefotaxime-resistant Acinetobacter species (from 2.4 +/- 2.2 to 5.4 +/- 4.0 patients/1,000 discharges; P = .02). Altering an antibiotic formulary may be a possible mechanism to contain the spread of selected resistant pathogens. However, close surveillance is needed to detect the emergence of other resistant pathogens.  (+info)

TY - JOUR. T1 - High-pressure liquid chromatographic assay of cefotaxime and desacetylcefotaxime in human myometrium. AU - Bawdon, R. E.. AU - Novick, W. J.. AU - Hemsell, D. L.. AU - Welch, W. D.. PY - 1984. Y1 - 1984. N2 - An analytic high-pressure liquid chromatographic (HPLC) procedure for the assay of desacetylcefotaxime and cefotaxime in gynecologic tissue was developed. Normal individuals undergoing elective hysterectomy were subjects in this study. Blood and myometrium were removed up to four hours after a l-g intramuscular dose of cefotaxime. Since cefotaxime is unstable in homogenized tissue at room temperature, the specimens must be maintained at 4 degree C during homogenization and extraction. Mean serum desacetylcefotaxime and cefotaxime levels were 3. 2 plus or minus 2. 0 mu g/ml and 6. 8 plus or minus 4. 4 mu g/ml, respectively. The mean myometrium concentrations of desacetylcefotaxime and cefotaxime were 8. 4 plus or minus 10. 0 mu g/g and 6. 3 plus or minus 8. 9 mu g/g, ...
The results of the present study indicate that during preterm delivery following PPROM, a standard intrapartum prophylaxis with a cefotaxime dose of 2 g followed by a dose of 1 g every 4 h achieved cefotaxime and desacetylcefotaxime concentrations in cord blood greater than the cefotaxime MIC90 and the desacetylcefotaxime MIC90 for E. coli and other members of the family Enterobacteriaceae.. The placental transfer of cefotaxime has previously been measured in late pregnancy during delivery by cesarean section (7). That study demonstrated that the level of cefotaxime remained comparatively high in the cord blood 6 h after the administration of 1 g of cefotaxime to the mother. Because the gestational age at the time of delivery is lower after PPROM, the placental transfer of the drug after PPROM could be different from that at term delivery. Our results give information about the placental transfer of cefotaxime and desacetylcefotaxime during preterm delivery following PPROM and show that PPROM ...
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Four ceftazidime-resistant Escherichia coli strains were isolated from elderly nursing home patients in a New York hospital during 1993. Strains MCQ-2, MCQ-3, and MCQ-4 were determined to be identical by pulsed-field gel electrophoresis and plasmid profiles, whereas strain MCQ-1 was unique. Strain MCQ-1 was determined to produce a TEM-10 beta-lactamase. Strains MCQ-2, MCQ-3, and MCQ-4 were also noted to be resistant to cefotaxime. These three strains produced two beta-lactamases with pIs of 5.4 (TEM-1) and 7.6. beta-Lactamase assays revealed that the pI 7.6 enzyme hydrolyzed cefotaxime faster (at a relative hydrolysis rate of 30% compared with that of benzylpenicillin) than either ceftazidime or aztreonam (relative hydrolysis rates of 13 and 3.3%, respectively). Nucleotide sequencing of the gene encoding the pI 7.6 beta-lactamase from strain MCQ-3 revealed a blaSHV-type gene differing from the gene encoding SHV-1 at four nucleotides which resulted in amino acid substitutions: phenylalanine for ...
This randomised prospective non-blinded study compared the pharmacokinetics, pharmacodynamics, antibiotic resistance and clinical efficacy of continuous vs intermittent administration of cefotaxime in 93 patients with chronic obstructive pulmonary disease (COPD) requiring hospitalisation for moderate to severe community acquired exacerbations (GOLD stages 2-4). Forty-seven patients received 2 g of cefotaxime as a continuous infusion over 24 h plus a loading dose of 1 g, while 46 patients received the drug intermittently (1 g three times daily). The mean duration of treatment was 10 days.. The most commonly isolated pathogens were Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis. Clinical cure was achieved in 37/40 (93%) with continuous infusion and 40/43 (93%) with intermittent administration (p = 0.93). No patients in the continuous group had antibiotic concentrations lower than minimal inhibitory concentration (MIC) compared with 40% in the intermittent group. Samples ...
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Background: Drug pharmacokinetics may be altered during liver transplantation. Cefotaxime (CTX), used as perioperative prophylaxis, demonstrates time-dependent killing and therefore continuous infusion might have pharmacodynamic advantages. Objectives: To determine the pharmacokinetics of CTX and desacetylcefotaxime (DCTX) in serum, bile and urine during continuous and intermittent infusion when performing liver transplantation. Methods: Fifteen patients undergoing liver transplantation were studied after continuous infusion (CI) (4000 mg iv per 24 h following a loading dose of 1000 mg) and intermittent bolus infusion (BI) (1000 mg iv four times daily). Samples were collected during the first 48 h after liver transplantation. Concentrations of CTX and DCTX were determined by HPLC. Results: During surgery, the mean concentration in serum after CI was 18 mg/L. The lowest serum concentration was 5 mg/L in the CI group and levels were undetectable in the BI group. Target serum concentrations of ≥4 ...
Clonal Spread of Cefotaxime-Resistant (CTX-R) Salmonella typhimurium in Belarus: Epidemiology and Molecular Analysis of Resistance Mechanisms
TY - JOUR. T1 - Role of pharmacokinetics and pharmacodynamics in the design of dosage schedules for 12-h cefotaxime alone and in combination with other antibiotics. AU - Nix, David E.. AU - Schentag, Jerome J.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - Pharmacodynamic principles have provided important tools to evaluate and compare antimicrobial agents, and well as to guide dosing. For β-lactams, time above the minimum inhibitory concentration (MIC) has surfaced as the most important factor. However, the area under the inhibitory serum concentration time-curve (AUIC) may be superior when appropriate dosing intervals are selected. Although the target time over the MIC is unclear in humans even when concentrations remain continuously above the MIC, a higher AUIC predicts better clinical outcome up to a maximum. This article provides a pharmacodynamic assessment of 1- and 2-g doses of cefotaxime every 12 h. AUIC24 values and published MIC values for common pathogens (grouped into four groups based on ...
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By preventing bacteria from making cell walls, cefotaxime can treat or prevent certain bacterial infections. This eMedTV resource contains information on cefotaxime, including how this antibiotic works, potential side effects, and safety precautions.
4. In patients with severe renal dysfunction, dosage of cefotaxime should be decreased accordingly. In patients with serum creatinine clearance greater than 424μmol/L (4.8mg) or renal corpuscle filtration less than 20ml/minute, half the maintenance dose of cefotaxime is recommended. If serum creatinine clearance greater than 751μmol/L (8.5mg), 1/4 of the maintenance dose of the drug is recommended. In patients undergoing hemodialysis, ...
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Cefotaxime is approved for adults and children who have infections caused by certain types of bacteria. This eMedTV page focuses on specific uses for cefotaxime. It also explores some of the reasons a doctor may prescribe the drug for unapproved purposes.
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The report generally describes cefotaxime sodium(sterile), examines its uses, production methods, patents. Cefotaxime Sodium(Sterile) market situation
Antimicrobial resistance is an increasing problem in Neisseria gonorrhoeae (NG) treatment. Presently, third-generation parenteral cephalosporins, like ceftriaxone and cefotaxime, are the first option. Resistance to oral, but not to parenteral, third-generation cephalosporins has been reported previously. We analysed the microbial susceptibility (as minimum inhibitory concentration - MIC) of NG cultures obtained from high-risk visitors of the largest Dutch outpatient clinic for sexually transmitted infections (STI) in Amsterdam, the Netherlands. Among 1,596 visitors, we identified 102 patients with at least one NG isolate with reduced susceptibility to cefotaxime (0.125 μg/ml < MIC ≤ 0.5 μg/ml). The percentage of NG isolates with reduced susceptibility to cefotaxime rose from 4.8% in 2006 to 12.1% in 2008 (chi2 17.5, p<0.001). With multivariate logistic regression, being a man who has sex with men (MSM) was significantly associated with reduced susceptibility to cefotaxime (p<0.001).
Cefotaxime is a member of the cephalosporin antibiotic class of drugs that has a rather wide spectrum of activity and is useful as a pre-surgery antibiotic.
What is this medicine? CEFOTAXIME (sef oh TAKS eem) is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections.
Cefotaxime, Sodium Salt - CAS 64485-93-4 - Calbiochem CAS 64485-93-4 Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis. - Find MSDS or SDS, a COA, data sheets and more information.
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38 medications are known to interact with cefotaxime. Includes Acetylsalicylic Acid (aspirin), Augmentin (amoxicillin/clavulanate), B Complex 100 (multivitamin).
Mode of action and Anti-microbial spectrum: Cefotaxime is an inhibitor of bacterial cell wall synthesis. High activity against gram-negative bacteria. Very often used for the elimination of Agrobacterium species after inoculation. High resistance against B-lactamase activity. Nontoxic to plant cells.. ...
Cefotaxime was found in Johns Hopkins Guides. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included.
Learn about the potential side effects of cefotaxime. Includes common and rare side effects information for consumers and healthcare professionals.
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This medicine is injected into a muscle, or infused through a vein. It is usually given by a health care professional in a hospital or clinic setting.. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
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One strain of Escherichia coli and two strains ofKlebsiella pneumoniae that had high levels of resistance to cefotaxime were isolated from the blood of patients in Seoul National University Childrens Hospital in 1995 and 1996. One strain ofShigella sonnei isolated from a pediatric patient on Cheju Island in 2000 also had a high level of cefotaxime resistance. By disk susceptibility testing, the strains were resistant to amoxicillin, cephalothin, and cefotaxime but were susceptible to ceftazidime, cefoxitin, and amoxicillin-clavulanic acid. Isoelectric focusing showed that the four strains produced a β-lactamase with an isoelectric point (pI) of 8.0. PCR with SHV-specific primers (3) was negative for all strains. Cefotaxime resistance was transferred by conjugation (9) from K. pneumoniaestrain 95151 along with a plasmid of 160 kb to E. coli J53 Azir (met proazide resistant) to produce E. coli J53 Azir/pMG267. The β-lactamase gene was cloned from plasmid pMG267 with EcoRI as an 8-kb insert into ...
Resistance to cephalosprins due to the production of extended spectrum beta-lactamases (ESBLs) or plasmid mediated AmpC beta-lactamases is increasingly found in infections in humans outside the hospital. The genes encoding for these beta-lactamases are located on mobile DNA (plasmids), which can be transferred between bacterial species. Although the source of ... read more these bacteria is unknown, a food-borne source cannot be excluded. From 2003 to 2007 cefotaxime resistance increases in bacteria from broilers, but not in isolates from calves, pigs and dairy cows. Cefotaxime resistance is indicative for the presence of ESBLs or plasmid mediated AmpC beta-lactamases. Molecular typing of the resistance genes and the plasmids of Escherichia coli and Salmonella isolates from broilers revealed the presence of a variety of ESBL/AmpC genes: blaCTX-M-1, blaCTX-M-2, blaTEM-52, blaSHV-2, blaTEM20, blaACC-1 and blaCMY-2, located on plasmids: IncI1, IncHI2/P, IncK and some untypeable plasmids. A study ...
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Boun Kim Tan, Emmanuel Vivier, Karim Ait Bouziad, Jean-Ralph Zahar, Christian Pommier, et al.. A hospital-wide intervention replacing ceftriaxone with cefotaxime to reduce rate of healthcare-associated infections caused by extended-spectrum β-lactamase-producing Enterobacteriaceae in the intensive care unit. Intensive Care Medicine, Springer Verlag, 2018, 44 (5), pp.672-673. ⟨10.1007/s00134-018-5079-y⟩. ⟨hal-02075873⟩ ...
TY - JOUR. T1 - Ciprofloxacin - Resistant typhoid with incomplete response to cefotaxime. AU - Adhikari, M. R.Prabha. AU - Baliga, Srikala. PY - 2002/3. Y1 - 2002/3. UR - UR - M3 - Article. C2 - 11924574. AN - SCOPUS:0036512711. VL - 50. SP - 428. EP - 429. JO - The Journal of the Association of Physicians of India. JF - The Journal of the Association of Physicians of India. SN - 0004-5772. IS - 3. ER - ...
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casSAR Dugability of O69395 | bla | Beta-lactamase Toho-2 - Also known as BLT2_ECOLX, bla. Hydrolyzes beta-lactam antibiotics such as penicillin G, carbenicillin, cephaloridine, cefoxitin, cefotaxime, ceftazidime, and aztreonam. Has especially increased relative hydrolysis rates for cephalothin, cephaloridine, cefotaxime and ceftizoxime.
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Renal failure commonly develops in the setting of SBP, and its development is a sensitive predictor of in-hospital mortality. The renal impairment is thought to stem from decreased effective arterial blood volume secondary to the systemic inflammatory response to the infection. In our current practice, there are certain circumstances in which we administer albumin early in the SBP disease course in order to reduce the risk of renal failure and mortality. Ultimately, our current protocol originated from the 1999 study of albumin in SBP by Sort et al.. The trial enrolled adults with SBP and randomized them to treatment with either cefotaxime and albumin infusion 1.5 gm/kg within 6hrs of enrollment, followed by 1 gm/kg on day 3 or cefotaxime alone. The primary outcome was the development of renal impairment (a nonreversible increase in BUN or Cr by more than 50% to a value greater than 30 mg/dL or 1.5 mg/dL, respectively) during hospitalization. The secondary outcome was in-hospital ...
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Antibiotics - Afix (Brand name: cefixime) cefixime, Aelxim-cl,Aerocef,Afix,Afixime,Anfix,Antima,Bactirid,Belfix-cv,Bestcef,Betixim,Cef-3,Cefarox,Cefibiotic,Cefila,Cefim,Cefimed,Cefimix,Cefit-oz,Cefit-xl,Cefixdura,Cefixim,Cefixoral,Cefrax,Ceftid,Ceftoral,Cefupa,Cefurex,Ceptik,Cexime,Cipcef,Comsporin,Covocef-n,Eficef,Emixef,Ethifix,Excef,Exiben,Faloxim,Fexim,Fix-a,Fixacep,Fixam,Fixef,Fixim,Fixiphar,Fixx,G-fix,Infectoopticef,Ixime,Keor,Lanfix,Longacef,Loxim,Magnacef,Maxicef,Megacef,Mytax-o,Neocef,Nucef,Nufex beta,Odacef,Ofex,Opixime,Orcef,Orfix,Pancef,Prexim,Profix,Roxim,Sefeena,Seferat,Sekispanon,Simcef,Sofix,Spaxim,Sporetik,Starcef,Supran,Supraxim,Taxim-o,Taxime,Texit,Tgocef,Tifaxcin,Tocef,Topcef,Triocef,Triocim,Trixim,Truso,Ultraxime,Unisec,Uro-cephoral,Urotricef,Urticef,Vexcef,Vixcef,Voitx-cv,Winex,Xibit-o,Zefral,Zimaks,Zofixi, Cefixime is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics..
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Product Number , 78097775. CAS Number , 75738-58-8. EC , Molecular Formula , C16H18ClN9O5S3. Molecular Weight , 548.02. Storage Temp , Harmonized Tariff code , 29419000. Signal Word , ...
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Cefixime. Indications. Cefixime is a cephalosporin antibacterial indicated in the treatment of adults and pediatric patients six months of age or older with the following infections when caused by susceptible isolates of the designated bacteria ...
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Alternatives include cefotaxime, fluoroquinolones, and co-trimoxazole. Jones TF (August 2003). "From pig to pacifier: ...
Claforan (cefotaxime sodium). Mifegyne (mifepristone, RU-486). Anandron (nilutamide). Revenue. US$ 3.01 billion (1996)[3]. ...
"Antagonistic effect of chloramphenicol in combination with cefotaxime or ceftriaxone". Archived from the original on September ...
Cefotaxime (1) is a potent cephalosporin antibiotic in its own right. Further modification of this drug by inclusion of a ... The acid in cefotaxime is first protected as its silyl ester (2) by derivatization with N-methyl-N-(trimethylsilyl) ... In general, cefquinome is within the same range as cefpirome and cefotaxime. Against Gram-negative species, cefquinome has very ...
Despite their name, a few are more active on ceftazidime than cefotaxime. They have mainly been found in strains of Salmonella ... Ceftriaxone, cefotaxime, and ceftazidime have failed even more often, despite the organism's susceptibility to the antibiotic ... These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the oxyimino-monobactam aztreonam. Thus ESBLs ... These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (e.g., ...
Soe GB, Overturf GD (1987). "Treatment of typhoid fever and other systemic salmonelloses with cefotaxime, ceftriaxone, ... a third-generation cephalosporin such as ceftriaxone or cefotaxime is the first choice.[28][29][30][31] Cefixime is a suitable ...
Wallace RJ Jr.; Tsukamura, M; Brown, BA; Brown, J; Steingrube, VA; Zhang, YS; Nash, DR (December 1990). "Cefotaxime-resistant ...
McPherson C, Gal P, Ransom JL (2008). "Treatment of Citrobacter koseri infection with ciprofloxacin and cefotaxime in a preterm ...
It rather resembles cefotaxime in its properties, but is not subject to metabolism. It was removed from the US Market in 2007. ... Injectable third generation cephalosporin antibiotic related to cefotaxime, q.v. Exhibits broad spectrum activity and ...
These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ...
Cefotaxime (1 g IV every six hours for seven days) and doxycycline (200 mg initially followed by 100 mg IV every 12 hours for ... November 2004). "An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe ... there is no evidence on differences in death reduction when benzylpenicillin is compared with ceftriaxone or cefotaxime. ...
In place of the easily hydrolyzed acetyl group of cefotaxime, ceftriaxone has a metabolically stable thiotriazinedione moiety. ...
Cephalosporins penetrate the cerebrospinal fluid poorly unless the meninges are inflamed; cefotaxime is a more suitable ...
For instance, in the United Kingdom, empirical treatment consists of a third-generation cefalosporin such as cefotaxime or ...
This treatment should last for 14 days after sterilization and then only cefotaxime for another 7 days creating a minimum of 21 ... For suspected Gram-negative enteric (including E. coli) meningitis a combination of cefotaxime and aminoglycoside, usually ...
... was targeted by cefotaxime. Colistin mecA LPSN Branham, Sara E. (1930-04-18). "A New Meningococcus-like Organism ( ...
... also known as cefotaxime clamidoxic acid (INN) Clamohexal (Hexal Australia) [Au]. clamoxyquine (INN) clanfenur (INN) clanobutin ...
Once in the hospital, the antibiotics of choice are usually IV broad spectrum 3rd generation cephalosporins, e.g., cefotaxime ...
Since cefotaxime use may be not appropriate for C. hominis endocarditis, an alternative regimen might include association of co ...
Third-generation cephalosporin antibiotics (i.e. cefotaxime, ceftriaxone) should be used to treat a suspected or culture-proven ...
... cefotaxime, ceftazidime, imipenem, meropenem, ciprofloxacin, levofloxacin, piperacillin-tazobactam, tigecycline and ...
Cefotan cefotaxime (INN) cefotetan (INN) cefotiam (INN) cefovecin sodium (USAN) cefoxazole (INN) cefoxitin (INN) cefozopran ( ...
... cefotaxime, or ceftazidime Gram stain negative and immunocompetent - vancomycin Gram stain negative and immunocompromised - ...
Tellurite and Cefotaxime Act Synergistically in Escherichia Coli', PloS (Public Library of Science) ONE, vol. 7, no. 4, doi: ...
... usually cefotaxime-ceftriaxone is generally avoided in neonates due to the theoretical risk of kernicterus.) The organisms ...
Azithromycin Cefixime Cefotaxime Ceftriaxone Cefuroxime Ciprofloxacin Clarithromycin Piperacillin/tazobactam (piperacillin + ...
Infectious diseases Antibiotics: Amoklavin (Amoxicillin/clavulanic acid) Claforan (Cefotaxime) Priftin (Rifapentine) Suprax ( ...
... cefotaxime, gentamicin, co-trimoxazole, and naladixic acid; 78% of the strains in that study were susceptible to doxycycline. ...
... oral cefixime or cefuroxime and injectable cefotaxime, ceftazidime, and ceftriaxone can be used with caution, but the use of ...

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  • CLAFORAN, equivalent to 1 gram and 2 grams cefotaxime, is supplied as frozen, premixed, iso-osmotic injections in plastic containers. (
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  • Use Cefotaxime (Claforan) exactly as directed on the label, or as prescribed by your doctor. (
  • When used for treating or preventing certain bacterial infections, cefotaxime ( Claforan ® ) works to kill bacteria by preventing them from forming cell walls. (
  • The most common adverse reactions experienced are: Pain and inflammation at the site of injection/infusion (4.3%) Rash, pruritus, or fever (2.4%) Colitis, diarrhea, nausea, vomiting (1.4%) Cefotaxime is a β-lactam antibiotic (which refers to the structural components of the drug molecule itself). (
  • Cefotaxime injection may also be used before surgery, and during and after a cesarean section, in order to prevent the patient from getting an infection. (
  • Cefotaxime injection is in a class of medications called cephalosporin antibiotics. (
  • Antibiotics such as cefotaxime injection will not work for colds, flu, or other viral infections. (
  • Cefotaxime injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). (
  • Cefotaxime injection is also available as a premixed product to be injected intravenously. (
  • How often you receive cefotaxime injection and the length of your treatment depends on the type of infection you have and how your body responds to the medication. (
  • You may receive cefotaxime injection in a hospital or you may administer the medication at home. (
  • If you will be receiving cefotaxime injection at home, your healthcare provider will show you how to use the medication. (
  • You should begin to feel better during the first few days of treatment with cefotaxime injection. (
  • Use cefotaxime injection until you finish the prescription, even if you feel better.If you stop using cefotaxime injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (
  • Cefotaxime injection is also sometimes used to treat typhoid fever (a serious infection that is common in developing countries), salmonella (an infection that causes severe diarrhea) and other types of infectious diarrhea, food poisoning, Lyme disease (an infection that may develop after a person is bitten by a tick), and a certain type of infection from dog bites. (
  • Also tell your doctor if you are allergic to any of the ingredients in cefotaxime injection. (
  • If you become pregnant while taking cefotaxime injection, call your doctor. (
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefotaxime for Injection, USP (cefotaxime sodium) and other antibacterial drugs, Cefotaxime for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (
  • Cefotaxime for Injection, USP contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. (
  • Solutions of Cefotaxime for Injection, USP range from very pale yellow to light amber depending on the concentration and the diluent used. (
  • Cefotaxime for Injection, USP is supplied as a dry powder in Pharmacy Bulk Packages containing cefotaxime sodium equivalent to 10 g of cefotaxime. (
  • Please read this leaflet carefully before you start using Cefotaxime Sandoz Powder for injection. (
  • A healthcare provider will give you this injection when cefotaxime is used to prevent infection from surgery. (
  • A stability-indicating high-performance liquid chromatographic assay method was used to study the stability of cefotaxime sodium (50 mg/mL) in 0.9% sodium chloride injection in polypropylene syringes at 5°C and 25°C. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on 5 injections was 1.1. (
  • Clinical studies on cefotaxime showed that reactions at the injection site, allergic reactions, and digestive problems were some of the possible side effects. (
  • Did the author experience injection site pain while taking cefotaxime ? (
  • DBL Cefotaxime Sodium for Injection (Powder for injection) is a brand of medicine containing the active ingredient Cefotaxime. (
  • IM injections of cefotaxime are prepared by adding 4ml 1% or 2% lidocaine injection to vials labeled containing 1g of cefotaxime. (
  • more than 4ml of sterile water for injection should be added to a vial labeled containing 1g of cefotaxime and the appropriate dose may then be injected directly into a vein over a 3-5 minutes period. (
  • 40ml sterile water for injection or 40ml 10% dextrose injection should be added to an infusion bottle containing 2g of cefotaxime and the solution should be infused within 20 minutes. (
  • 2g of cefotaxime can also be reconstituted using 100ml compatible IV solution or 10% dextrose injection and be infused within 40-60 minutes. (
  • Cefotaxime sodium EUROPEAN PHARMACOPOEIA 7.0 Injection 10μL of the test solution and reference solutions (b) (c) and (d). (
  • What is Cefotaxime Injection (Cefotaxime Sodium) used for? (
  • Cefotaxime Injection (Cefotaxime Sodium) belongs to the cephalosporin group of antibiotics. (
  • How should I use Cefotaxime Injection (Cefotaxime Sodium)? (
  • Cefotaxime Injection (Cefotaxime Sodium) is either injected into a muscle, such as the buttock, or else given as an intravenous fluid which may be injected into the vein. (
  • Strictly follow all instructions provided to you by your physician or pharmacist while using Cefotaxime Injection (Cefotaxime Sodium). (
  • Our range of products include 500 mg cefotaxime injection, 500 mg cloxacillin sodium injection, 500 mg ceftriaxone and 250 mg sulbactam injection, 500 mg cefotaxime and 250 mg sulbactam injection, 250 mg ceftazidime and 31.25 mg tazobactam injection and 500 mg ceftazidime and 62.5 mg tazobactam injection. (
  • Our range of products include 500 mg cefotaxime injection, ketoconazole soap, potassium citrate and citric acid syrup, acne off soap, ketoconazole and cetrimide soap and 10 mg amlodipine tablets. (
  • Cefotaxime sodium API is widely for single injection and compound injection. (
  • Contact us if you need more details on 10% Cefotaxime Crystal Free Acid Injection. (
  • Cefotaxime is an antibiotic used to treat a number of bacterial infections. (
  • As a β-lactam antibiotic in the third-generation class of cephalosporins, cefotaxime is active against numerous Gram-positive and Gram-negative bacteria, including several with resistance to classic β-lactams such as penicillin. (
  • Sterile cefotaxime sodium is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. (
  • Cefotaxime is a member of the cephalosporin antibiotic class of drugs that has a rather wide spectrum of activity and is useful as a pre-surgery antibiotic. (
  • Cefotaxime is a cephalosporin (SEF a low spor in) antibiotic. (
  • You should not use this medicine if you are allergic to cefotaxime or another cephalosporin antibiotic ( cefdinir , cefalexin, Keflex , Omnicef , and others). (
  • You should not use cefotaxime if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic (cefdinir, cefalexin, Keflex, Omnicef, and others). (
  • CEFOTAXIME (sef oh TAKS eem) is a cephalosporin antibiotic. (
  • The goal of this study was to evaluate the in vivo effects of the OAT3-Ile305Phe variant (rs11568482), present at 3.5% allele frequency in Asians, on drug disposition with a focus on cefotaxime, a cephalosporin antibiotic. (
  • Cefotaxime is a cephalosporin antibiotic. (
  • Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. (
  • Because 3rd generation cephalosporins exhibit specific activities against bacteria, a 30 micrograms cefotaxime disk should be used when performing Kirby-Bauer disk susceptibility tests for this antibiotic. (
  • Cefotaxime sodium is a broad spectrum third generation cephalosporin antibiotic. (
  • Cefotaxime is a third-generation cephalosporin antibiotic. (
  • Cefotaxime Sodium Salt, a cephalosporin antibiotic, is used against numerous Gram-positive and Gram-negative bacteria. (
  • Cefotaxime is a β-lactam antibiotic (which refers to the structural components of the drug molecule itself). (
  • Since antibiotic-resistance makes some problems in the treatment of diseases caused by these groups of bacteria, this study was designed to determine the relationship between serotypes and minimum inhibitory concentration (MIC) of Ampicillin, Cefazolin, and Cefotaxime in Yersinia isolates and also the sensitivity of Yersinia to these antibiotics. (
  • Background/Aims: Cefotaxime or ceftriaxone were considered the first-choice antibiotic for empirical treatment in cirrhotic patients developing spontaneous bacterial Peritonitis. (
  • citation needed] Cefotaxime is contraindicated in patients with a known hypersensitivity to cefotaxime or other cephalosporins. (
  • Hypersensitivity to cefotaxime or other cephalosporins. (
  • Ceftriaxone and cefotaxime are two injectable injectable third-generation cephalosporins (C3G) commonly used in clinical practice. (
  • The increased prevalence of NG strains with reduced susceptibility to cefotaxime among MSM may herald resistance to third-generation parenteral cephalosporins. (
  • However, unlike many other cephalosporins, cefotaxime is not effective against Pseudomonas aeruginosa bacteria. (
  • Unlike the first generation cephalosporins (and most 2nd generation agents), cefotaxime will enter the CSF in therapeutic levels (at high dosages) when the patient's meninges are inflamed. (
  • Cefotaxime sodium salt is an antimicrobial drug that is administered by parenteral administration and is included in the category of cephalosporins. (
  • Number of cefotaxime-nonsusceptible Senterica isolates carrying extended-spectrum β-lactamase (black bars) and AmpC genes (gray bars) in Finland, 1993-2011. (
  • The MIC values for cefotaxime of the original isolates and the transconjugants were greater than 128 mg l-1 and 64 mg l-1, respectively. (
  • Isolates of S.typhimurium resistant to cefotaxime were first identified in Argentina in 1990. (
  • This preliminary study supports the use of cefotaxime for intrapartum prophylaxis in women colonized with ampicillin-resistant isolates of Enterobacteriaceae . (
  • The minimal inhibitory concentrations (MICs) of aztreonam and cefotaxime were determined against 400 isolates from urological in-patients with complicated and/or hospital acquired urinary tract infections (UTI). (
  • To characterize the genetic determinants involved in the reduced susceptibility to ciprofloxacin and cefotaxime in Salmonella enterica serotype Enteritidis clinical isolates obtained from four patients in summer 2003 in Hong Kong. (
  • Three Salmonella Enteritidis isolates from blood culture and one from stool were collected due to their increased resistance to ciprofloxacin and cefotaxime. (
  • The Relationship ofYersinia Isolates Bioserotypeswith Minimum Inhibitory Concentration of Ampicillin, Cefazolin, and Cefotaxime', Journal of Kerman University of Medical Sciences , 24(1), pp. 38-49. (
  • Our aim was to investigate whether a standardized dosage regimen of intrapartum cefotaxime could provide concentrations in the cord blood greater than the cefotaxime MIC 90 for E. coli . (
  • For neonates younger than 7 days of age, a recommended cefotaxime dosage is 25mg/kg every 12 hours. (
  • 4. In patients with severe renal dysfunction , dosage of cefotaxime should be decreased accordingly. (
  • Population Pharmacokinetics of Cefotaxime and Dosage Recommendations in Children with Sickle Cell Disease. (
  • In the present study, our aims were to determine cefotaxime pharmacokinetics when prescribed to children with SCD for suspected or proven bacterial infection, identify significant covariates, and perform Monte Carlo simulations to optimize the drug dosage. (
  • However, ceftriaxone has the advantage of once-daily dosing, whereas the shorter half-life of cefotaxime necessitates two or three daily doses for efficacy. (
  • The mean half-life of cefotaxime in infants with lower birth weights (≤1500 grams), regardless of age, was longer (4.6 hours) than the mean half-life (3.4 hours) in infants whose birth weight was greater than 1500 grams. (
  • Because tubular secretion is involved in the renal excretion of the drug, probenecid has been demonstrated in several species to prolong the serum half-life of cefotaxime. (
  • Indeed, their results conclude that resistance development is weaker, as well as more limited carriage of HL-CASE Enterobacterial strains by replacing ceftriaxone with cefotaxime. (
  • Between 1986 and 1988, multiresistant Klebsiella pneumoniae strains exhibiting high-level cefotaxime resistance were isolated from patient specimens particularly of the intensive care units of the Aachen Technical University Hospital. (
  • Both strains had identical susceptibility to cefotaxime (0.008 μg/ml) and ciprofloxacin (0.5μg/ml) in repeated testing experiments with the conventional microdilution NCCLS method ( 10 ). (
  • While Klebsiella strains donated cefotaxime, cefamandole and cefuroxime resistance to Escherichia coli K-12 recipients, the genetic analysis of exconjugants after the transfer of plasmids from Serratia strains to Proteus or Salmonella recipients showed that the cefoxitin resistance determinant was also co-transferred. (
  • In subsequent transfer cycles of this plasmid, cefotaxime and cefoxitin resistance determinants segregated in contrast to the relative stability of plasmids derived from Klebsiella strains in subsequent transfer cycles. (
  • The MIC 90 of cefotaxime for E. coli strains (0.125 mg/liter) was achieved in all cases. (
  • Many anaerobes are also susceptible to cefotaxime, including strains of Bacteroides fragilis , Clostridium sp . (
  • Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study. (
  • it provides many singles doses of cefotaxime for addition to suitable parenteral fluids in the preparation of admixtures for intravenous infusion. (
  • A single 50 mg/kg dose of cefotaxime was administered as an intravenous infusion over a 10- to 15-minute period to 29 newborn infants grouped according to birth weight and age. (
  • 1 g of intravenous ceftriaxone has an average wholesale price of $46 compared with $12 for 1 g of intravenous cefotaxime. (
  • Cefotaxime belongs to a group of medicines called cephalosporin antibiotics. (
  • Although, several antibiotics including cefotaxime, ceftriaxone, or ciprofloxacin are being used, it is unclear which drug is most effective. (
  • The study will have two periods: Period 1 during which patients hospitalized in the emergency department or in internal medicine and receiving C3G antibiotics will receive ceftriaxone, and the period 2 during which cefotaxime is cephalosporin used in first intention in these same patients. (
  • Cefotaxime belongs to a group of drugs called cephalosporin antibiotics, which work to stop the growth of bacteria in the body. (
  • Cefotaxime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. (
  • Cefotaxime Sodium is contraindicated in patients with known hypersensitivity to the cephalosporin group of antibiotics or those that had an anaphylactic shock or immediate-type hypersensitivity reaction to penicillins. (
  • Cefotaxime, like other β-lactam antibiotics does not only block the division of bacteria, including cyanobacteria , but also the division of cyanelles, the photosynthetic organelles of the Glaucophytes , and the division of chloroplasts of bryophytes . (
  • The third-generation cephalosporin antibiotics ceftriaxone and cefotaxime are widely used for prophylaxis in abdominal surgery. (
  • Pharmacokinetics (specific) - Cefotaxime is not appreciably absorbed after oral administration and must be given parenterally to attain therapeutic serum levels. (
  • Cefotaxime pharmacokinetics were best described by a one-compartment model: the median estimated weight-normalized volume of distribution and clearance were 0.42 liter/kg (range, 0.2 to 1.1 liter/kg) and 0.38 liter/h/kg (range, 0.1 to 1.2 liter/h/kg). (
  • Chemistry - A semisynthetic, 3rd generation, aminothiazolyl cephalosporin, cefotaxime sodium occurs as an odorless, white to off-white crystalline powder with a pK a of 3.4. (
  • The kit includes pre-weighed cefotaxime (sodium) powder, a sterile filter and a sterile container for the filtered solution. (
  • Cefotaxime (CTX), used as perioperative prophylaxis, demonstrates time-dependent killing and therefore continuous infusion might have pharmacodynamic advantages. (
  • The authors conclude that ceftriaxone and cefotaxime provide effective prophylaxis for abdominal surgeries, but that cefotaxime does not provide adequate coverage for appendectomy without the addition of metronidazole. (
  • This is not a complete list of cefotaxime drug interactions. (
  • Following IM administration of a single 500 mg or 1 g dose of cefotaxime to normal volunteers, mean peak serum concentrations of 11.7 and 20.5 mcg/mL respectively were attained within 30 minutes and declined with an elimination half-life of approximately 1 hour. (
  • In addition, the hypothesis is that, contrary to current data, cefotaxime is found at sufficiently high concentrations in the feces to have an impact on the microbiota equivalent to that of ceftriaxone, despite less significant biliary elimination. (
  • A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA + isogenic ancestor was challenged with low cefotaxime concentrations. (
  • Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of the tested selected variants harbored the Thr550→Ala mutation in pbp2x . (
  • A competition model-system was established here to test whether subinhibitory cefotaxime concentrations were able to select a hypervariable hexA mutant S. pneumoniae population over its isogenic hexA + ancestor and also to determine the reasons and possible consequences of this selective event. (
  • The concentrations of cefotaxime in the cord blood ranged from 0.5 to 8.5 mg/liter. (
  • Cefotaxime also is distributed into milk in low concentrations. (
  • Cefotaxime serum concentrations were measured in 78 pediatric SCD patients receiving cefotaxime intravenously at a daily dose of 200 mg/kg of body weight in three or four divided doses over 30 min. (
  • Cefotaxime concentrations ranged from 0.05 to 103.7 mg/liter. (
  • Uses/Indications - In the United States, there are no cefotaxime products approved for veterinary species, but it has been used clinically in several species when an injectable 3rd generation cephalosporin may be indicated. (
  • There was a dose‑dependent increase in serum levels after the IV administration of 500 mg, 1 g, and 2 g of cefotaxime (38.9, 101.7, and 214.4 mcg/mL respectively) without alteration in the elimination half-life. (
  • Cefotaxime crosses the placenta and activity in amniotic fluid either equals or exceeds that in maternal serum. (
  • Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. (
  • Did the author experience serum sickness while taking cefotaxime ? (
  • In patients with serum creatinine clearance greater than 424 μ mol/L (4.8mg) or renal corpuscle filtration less than 20ml/minute, half the maintenance dose of cefotaxime is recommended. (
  • In a context where the emergence of multidrug-resistant bacteria continues to increase, it seems appropriate to conduct a study to compare the impact of the use of ceftriaxone or cefotaxime on the emergence of BMR at the individual level. (
  • In the absence of a study clearly establishing the link between C3G types (ceftriaxone, cefotaxime) and the emergence of BMR and in line with the above research, this study aims to compare the microbiological impact of the use of either of these two C3Gs (in terms of emergence of bacterial resistance and impact on the diversity and quantity of digestive digestive bacteria). (
  • Pharmacology/Spectrum of Activity - Cefotaxime has a relatively wide spectrum of activity against both gram positive and gram negative bacteria. (
  • Cefotaxime has activity in the presence of some beta-lactamases both penicillinases and cephalosporinases of Gram-negative and Gram-positive bacteria. (
  • How to use Cefotaxime SODIUM Vial. (
  • Aug 01 2019 · 1 g/vial (as cefotaxime sodium) DIN (Canada) 2 g/vial (as cefotaxime sodium) DIN (Canada) Note DIN refers to Drug Identification Number for products approved by Health Canada. (
  • as expected, the cefotaxime-resistant mutants had a mutation frequency 10 times higher in response to to ciprofloxacin. (
  • A 30-year-old woman received cefotaxime, fosfomycin and ciprofloxacin for sinusitis. (
  • Based on the susceptibility and conjugation experiment results, previously described PCR methods were employed to detect sequences homologous to qnr and bla CTX-M suspected to be involved in the reduced susceptibility to ciprofloxacin and cefotaxime, respectively. (
  • Adhikari, MRP & Baliga, S 2002, ' Ciprofloxacin - Resistant typhoid with incomplete response to cefotaxime ', Journal of Association of Physicians of India , vol. 50, no. 3, pp. 428-429. (
  • It has that ciprofloxacin could be an alternative to cefotaxime or ciprofloxacin in cirrhotic patients developing spontaneous bacterial peritonitis. (
  • The aim of the present study was to compare oral ciprofloxacin with cefotaxime and ceftriaxone in the treatment of-spontaneous bacterial peritonitis in cirrhotic patients. (
  • Mode of action and Anti-microbial spectrum: Cefotaxime is an inhibitor of bacterial cell wall synthesis. (
  • Cefotaxime inhibits bacterial cell wall synthesis by binding to penic. (
  • Cefotaxime sodium is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. (
  • Cefotaxime is an inhibitor of bacterial cell wall synthesis. (
  • Changing patterns in microbial resistance suggest cefotaxime may be suffering greater resistance than ceftriaxone, whereas the two were previously considered comparable. (
  • In the present study we explored the genetic relatedness and resistance mechanisms to b -lactams of 15 cefotaxime-resistant (CTX-R) S.typhimurium isolated in 7 Belarussian hospitals during 1994 - 2000. (
  • The determinants of resistance were transferred by conjugation to E.coli AB1456 (Rif R ). Two types of transconjugants (TRCs) were selected on agar containing rifampin with either cefotaxime or ampicillin. (
  • Unlike β-lactams such as penicillin and amoxicillin, which are highly susceptible to degradation by β-lactamase enzymes (produced, for example, nearly universally by S. aureus), cefotaxime boasts the additional benefit of resistance to β-lactamase degradation due to the structural configuration of the cefotaxime molecule. (
  • A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives. (
  • Cefotaxime is also used to prevent infection in people having certain types of surgery. (
  • Cefotaxime will not treat a viral infection such as the flu or a common cold . (
  • We aimed to compare outcomes between patients treated with BLBLIs and carbapenems for bloodstream infection (BSI) caused by cefotaxime non-susceptible (likely ESBL- or AmpC β-lactamase-producing) Escherichia coli and Klebsiella pneumoniae.All adult patients with a BSI caused by cefotaxime non-susceptible E. coli or K. pneumoniae were included from May 2012-May 2013. (
  • There were no significant differences in subsequent isolation of carbapenem resistant organisms (4.3% vs. 4.2%, p = 1.0), C. difficile infection (13.0% vs. 8.3%, p = 0.67) or relapsed BSI (0% vs. 2%, p = 0.23).BLBLIs appear to have a similar efficacy to carbapenems in the treatment of cefotaxime-resistant E. coli and K. pneumoniae bloodstream infections. (
  • The number of patients with chest or urinary tract infections was reduced significantly in the ceftriaxone group (6 percent compared with 11 percent in the cefotaxime group), and the percentage of patients who developed any infection also was reduced significantly with ceftriaxone (20 percent compared with 27 percent). (
  • Cefotaxime is frequently prescribed in pediatric patients with sickle cell disease (SCD), characterized by vaso-occlusive complications, chronic hemolytic anemia, and a defective immunological function predisposing the individual to severe infection. (
  • Approximately 20-36% of an intravenously administered dose of 14 C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite. (
  • Cefotaxime was given intravenously during delivery, as follows: 2 g at the onset of labor and then 1 g every 4 h until delivery. (
  • CNS infections - e.g. meningitis/ventriculitis secondary to N. meningitidis, H. influenzae, S. pneumoniae Although cefotaxime has demonstrated efficacy in these infections, it is not necessarily considered to be the first-line agent. (
  • Adapted with permission from Woodfield JC, Van Rij AM, Pettigrew RA, van der Linden AJ, Solomon C, Bolt D. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. (
  • The Cefotaxime Sodium API market research report splits the regional landscape of this industry space into USA, Europe, Japan, China, India, South East Asia. (
  • A logistic regression analysis showed that treatment with cefotaxime was still associated with a higher response rate after adjusting for several potential confounding factors. (
  • Given its broad spectrum of activity, cefotaxime is used for a variety of infections, including: Lower respiratory tract infections - e.g. pneumonia (most commonly caused by S. pneumoniae) Genitourinary system infections - urinary tract infections (e.g. (
  • Cefotaxime Sandoz is also used to prevent infections before, during and after surgery. (
  • Cefotaxime is used to treat many kinds of bacterial infections , including severe or life-threatening forms. (
  • Cefotaxime is a medication used to treat bacterial infections. (
  • In a prospective, randomized, double-blind study, we compared cefotaxime with nafcillin plus tobramycin in the treatment of serious bacterial infections. (
  • We conclude that cefotaxime may be more effective and less toxic than nafcillin plus tobramycin for patients with serious bacterial infections. (
  • Cefotaxime has been shown to be active against a wide range of gram-positive and gram-negative organisms responsible for clinical infections like early neonatal sepsis, such as members of the family Enterobacteriaceae (mainly E. coli ) and Haemophilus influenzae . (
  • Comparable outcomes for β-lactam/β-lactamase inhibitor combinations and carbapenems in definitive treatment of bloodstream infections caused by cefotaxime-resistant Escherichia coli or Klebsiella pneumoniae. (
  • de Vries H JC , van der Helm J J , Schim van der Loeff M F , van Dam A P . Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands. (
  • avoid cefotaxime doses >6g/day. (
  • In patients undergoing hemodialysis, 0.5 -2g should be given as single daily doses and a supplemental dose of cefotaxime should be given after each dialysis period. (
  • Dr T C. Martin on March went to Philadelphia New York and cefotaxime dose into their place and held by means of a catgut suture. (
  • It contains the active ingredient cefotaxime sodium. (
  • The Cefotaxime (Sodium) EZ Pak™ is the fastest and easiest way to make a set amount of sterile cefotaxime (sodium) solution. (
  • The bactericidal activity of cefotaxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). (
  • A total of 38 drugs (338 brand and generic names) are known to interact with cefotaxime . (
  • All commonly used IV fluids and the following drugs are reportedly compatible with cefotaxime: metronidazole and verapamil. (
  • Notable organisms against which cefotaxime is not active include Pseudomonas and Enterococcus. (
  • 3 cartridges of SD040 Cefotaxime 30 mcg and 3 cartridges of SD274 Cefotaxime 30mcg and Clavulanic acid 10mcg. (
  • Cefotaxime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. (
  • Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. (
  • Cefotaxime shows high affinity for penicillin-binding proteins in the cell wall including PBP Ib and PBP III. (
  • In meningitis, cefotaxime crosses the blood-brain barrier better than cefuroxime. (
  • Read the side effects of Cefotaxime as described in the medical literature. (
  • This is not a complete list of cefotaxime side effects. (
  • Serious side effects have been reported with cefotaxime. (
  • This article covers many, but not all, of the possible side effects with cefotaxime. (
  • Some side effects of cefotaxime are potentially serious and should be reported immediately to your healthcare provider. (
  • untary efforts of the mother accomplish but little the child is doubled on cefotaxime sodium cefotaxime side effects a question of pathology and this is the reason why that paper hour or two after the pack the temperature dropped. (
  • Cefotaxime is injected into a muscle, or given as an infusion into a vein. (
  • While regional susceptibilities must always be considered, cefotaxime typically is effective against these organisms (in addition to many others): Staphylococcus aureus (not including MRSA) and S. epidermidis Streptococcus pneumoniae and S. pyogenes Escherichia coli Haemophilus influenzae Neisseria gonorrhoeae and N. meningitidis Klebsiella spp. (
  • Furthermore, the net secretory component of cefotaxime renal clearance (CLsec ) was reduced in volunteers heterozygous for the variant allele [33.3 ± 31.8 mL/min (mean ± SD)] compared with volunteers homozygous for the OAT3 reference allele [97.0 ± 42.2 mL/min (mean ± SD), p = 0.01]. (
  • Cefotaxime has renal excretion and therefore preferred over ceftriaxone. (
  • In a prospective randomized study 39 urological patients with complicated and/or hospital acquired UTI were treated with 1 g aztreonam or cefotaxime iv twice daily for 4 to 15 days. (
  • Cure was obtained in 5 out of 18 patients in the aztreonam and 7 out of 20 patients in the cefotaxime group. (
  • There were 3 superinfections, 7 relapses and 3 reinfections in the aztreonam group and 1 failure, 1 superinfection, 6 relapses and 5 reinfections in the cefotaxime group. (
  • This leaflet answers some common questions about Cefotaxime Sandoz. (
  • In 1993, there was a change from ceftriaxone to cefotaxime in the inpatient pediatric division of the Johns Hopkins Hospital. (
  • Despite their similar spectrum of action, it should be noted that they have substantially different pharmacokinetic properties, especially with regard to their half-life and their elimination routes (mainly urinary for cefotaxime, mixed: biliary and urinary for ceftriaxone). (
  • Cefotaxime adalah fitur positif yang menunjukkan resistensi terhadap penisilinase dan berguna untuk mengobati infeksi yang resisten terhadap turunan penisilin. (

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