A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Microbial Sensitivity Tests
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Drug Resistance, Microbial
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.
Glossitis, Benign Migratory
An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.
Borrelia burgdorferi Group
Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.
In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (1/172)A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against > or = 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had > or = 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxime and ticarcillin/clavulanate, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime, 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, five agents had activity against > or = 90% of all 1921 urinary tract pathogens tested (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had > or = 95% activity against Enterobacteriaceae from urinary tract infection (ciprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen agents had activity against > or = 95% of Staphylococcus aureus strains. Susceptibility of Pseudomonas aeruginosa isolates ranged from 2% to 91%. (+info)
Markedly different rates and resistance profiles exhibited by seven commonly used and newer beta-lactams on the selection of resistant variants of Enterobacter cloacae. (2/172)Seven beta-lactam antibiotics (cefepime, cefoperazone, ceftazidime, ceftriaxone, cefamandole, imipenem and meropenem) were tested for their potential to select resistance in standard and clinical strains of Enterobacter cloacae (n = 9). The strains were subcultured daily with the test antibiotics at doubling concentrations starting at 0.125 x MIC. Development of resistance throughout the passages was detected by a disc diffusion test. Ceftazidime, ceftriaxone and cefamandole selected resistance at a faster rate than cefoperazone, cefepime and meropenem. Imipenem did not select resistance in the nine strains tested and was the only antibiotic that eradicated all the strains during selection. The resistance patterns of strains selected by meropenem, cefepime and the other cephalosporins were markedly different, although cross-resistance to the early generation cephalosporins was common. The resistance phenotypes of most strains remained stable upon serial passages in antibiotic-free medium. The findings of this study highlight the importance of the choice of antibiotic for therapy not only on the basis of its antibacterial activity, but also on its potential to select resistance to itself and other antibiotics. (+info)
Investigation of the synergic effects of aminoglycoside-fluoroquinolone and third-generation cephalosporin combinations against clinical isolates of Pseudomonas spp. (3/172)Antimicrobial synergy resulting from antibiotic combination therapy is often important in the treatment of serious bacterial infections. Previous studies have demonstrated synergy between an aminoglycoside and beta-lactam antibiotics in the treatment of Pseudomonas aeruginosa infections. The present paper investigates the synergic effects of aminoglycosides (amikacin and netilmicin) and fluoroquinolones (ciprofloxacin, ofloxacin and pefloxacin) in combination with third-generation cephalosporins (cefoperazone, ceftriaxone and ceftazidime) against 18 clinical isolates of Pseudomonas spp. The effects of these drugs were examined by three methods (disc diffusion, 'chequerboard' titration and the time-killing method), to evaluate the activities of the antibiotics alone and in combination against selected isolates. Fractional inhibitory concentration indices were calculated for all isolates with all combinations. Use of the disc diffusion method revealed that amikacin and netilmicin in combination with the three cephalosporins exhibited synergy against 7-12 isolates, whereas the combinations of quinolones and ceftazidime displayed synergic effects only in the case of 3-5 isolates. On 'chequerboard' titration, amikacin and ceftriaxone exerted synergy against seven of the isolates. The other combinations showed synergy against fewer isolates, but every combination demonstrated synergic effect against some of the isolates. The tested combinations had different effects against various Pseudomonas spp. With the time-killing method, the 1/2 x MIC of amikacin or ciprofloxacin in combination with the 1/2 x MIC of third-generation cephalosporins proved to be most effective. No antagonism was found with these combinations. Discrepancies in the detection of synergy were observed for the different methods. (+info)
Cefoperazone prevents the inactivation of alpha(1)-antitrypsin by activated neutrophils. (4/172)At sites of neutrophilic inflammation, tissue injury by neutrophil elastase is favored by phagocyte-induced hypochlorous acid-dependent inactivation of the natural elastase inhibitor alpha(1)-antitrypsin. In the present study, cefoperazone prevented alpha(1)-antitrypsin inactivation by neutrophils and reduced the recovery of hypochlorous acid from these cells. Moreover, the antibiotic reduced the free elastase activity in a neutrophil suspension supplemented with alpha(1)-antitrypsin without affecting the cells' ability to release elastase. These data suggest that the drug inactivates hypochlorous acid before its reaction with alpha(1)-antitrypsin, thereby permitting the antiprotease-mediated blockade of released elastase. In conclusion, cefoperazone appears to have the potential for limiting elastase-antielastase imbalances, attenuating the related tissue injury at sites of inflammation. (+info)
Prevalence of Campylobacter, Arcobacter, Helicobacter, and Sutterella spp. in human fecal samples as estimated by a reevaluation of isolation methods for Campylobacters. (5/172)The aims of this study were to investigate the prevalence of campylobacteria including Campylobacter jejuni subsp. jejuni (C. jejuni) and Campylobacter coli in human clinical samples and in samples from healthy individuals and to reevaluate the efficacies of conventional selective methods for isolation of Campylobacter spp. Two charcoal-based selective media, modified charcoal cefoperazone deoxycholate agar (mCCDA) and cefoperazone-amphotericin-teicoplanin (CAT) agar, were compared with Skirrow's blood-based medium and with a filter method (filter) applied to a yeast-enriched blood agar. A total of 1,376 specimens were tested on all four media, and the percentages of thermophilic Campylobacter-positive specimens isolated on Skirrow's medium, filters, CAT agar, and mCCDA were 82, 83, 85, and 95%, respectively. When additional samples were processed with the three selective media, mCCDA recovered significantly more thermophilic Campylobacter spp. than Skirrow's medium (P = 0.0034). No significant difference between Skirrow's medium and CAT agar was observed in this study. Another six taxa were identified, namely, Campylobacter concisus, Campylobacter curvus-like bacteria, Arcobacter butzleri, Arcobacter cryaerophilus, Helicobacter cinaedi, and Sutterella wadsworthensis. Most of these strains were isolated after 5 to 6 days of incubation by use of the filter technique. This paper provides evidence for the existence of S. wadsworthensis in human feces from clinical cases of gastrointestinal disorders and in feces from a healthy individual. Furthermore, C. concisus was isolated from a large number of diarrheal cases, particularly those at the extremes of age, but was additionally isolated from the feces of healthy people. Further investigations to establish the role of C. concisus and S. wadsworthensis in enteric disease is needed. We conclude that a range of campylobacteria may cause infections in Denmark. (+info)
Multilocular pyogenic hepatic abscess complicating ascaris lumbricoides infestation. (6/172)A 74-year-old man was admitted to our hospital with frequent right flank pain. The multiple multilocular hepatic abscesses were revealed by computed tomography. Radiographs following a barium meal showed a linear filling defect in the ileum consistent with ascariasis. One day after treatment with pyrantel pamoate, an Ascaris was passed in the stool. The pyogenic hepatic abscesses gradually healed with both antibiotics and continuous drainage. After 2 months, he was discharged. In this case, the pyogenic hepatic abscesses were thus considered to have been caused by an inflammation which spread through the portal vein. (+info)
Susceptibility of clinical isolates of Bacteroides fragilis group strains to cefoxitin, cefoperazone and ticarcillin/clavulanate. (7/172)A total of 40 strains of the B. fragilis group was isolated from clinical specimens in two hospital centers in Fortaleza from 1993 to 1997. The most frequently isolated species was Bacteroides fragilis (19 strains) and most isolates came from intra-abdominal and wound infections. The susceptibility profile was traced for cefoxitin, cefoperazone and ticarcillin-clavulanate by using the agar dilution reference method. All isolates were susceptible to ticarcillin-clavulanate (128/2 microg/ml). Resistance rates of 15 and 70% were detected to cefoxitin (64 microg/ml) and cefoperazone (64 microg/ml), respectively. Such regional results permit a better orientation in choosing this group of antibiotics for prophylaxis and therapy especially in relation to cefoxitin, which is frequently used in the hospital centers studied. (+info)
In-vitro susceptibility of Burkholderia pseudomallei to cefoperazone-sulbactam combination. (8/172)Melioidosis is endemic in Malaysia. Emerging resistance with new and current antimicrobial agents has underscored the need to look further for new antimicrobial agents for the treatment of melioidosis. Hence, we evaluated the in-vitro susceptibility of fifty locally isolated strains of Burkholderia pseudomallei, the causative agent of melioidosis to cefoperazone-sulbactam combination using the method of NCCLS. All the fifty strains tested were susceptible in-vitro to cefoperazone-sulbactam. The MIC90 of the organism for cefoperazone-sulbactam was 4 mg/L. The results of our findings suggested that cefoperazone-sulbactam may be useful in the treatment of melioidosis. (+info)
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Hypersensitivity vasculitis induced by cefoperazone/sulbactam | Annals of Clinical Microbiology and Antimicrobials | Full Text
Cefoperazone has not been reported to cause vasculitic complications before. Here, we report a case of hypersensitivity vasculitis associated with cefoperazone/sulbactam. A 13-year-old girl with appendicitis developed hypersensitivity vasculitis on the fifth day of cefoperazone/sulbactam therapy. Hypersensitivity vasculitis resolved gradually after removal of the agent on the seventh day and did not recur. Although hypersensitivity vasculitis has multiple causes, coexistence of hypersensitivity vasculitis and cefoperazone treatment, and the quite resolution of the disease after removal of the drug, strongly favours a causative relationship. To our knowledge, this is the first report of a hypersensitivity vasculitis associated with cefoperazone.
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In vitro studies on protein binding of rifampicin - Publications of the IAS Fellows
1. Protein binding of rifampicin to varying albumin concentrations was carried out in vitro. Effect on other antitubercular drugs on protein binding of rifampicin was also studied. 2. The results indicated that rifampicin binding was influenced by albumin concentration, suggesting that it was chiefly bound to albumin. 3. Presence of other antitubercular drugs along with rifampicin decreased the percentage of bound rifampicin. ...
Cefoperazone | Daviss Drug Guide
Find information on Cefoperazone in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Ceforex (Cefoperazone Sodium; Sulbactam) Hauz Pharma
Ceforex information about active ingredients, pharmaceutical forms and doses by Hauz Pharma, Ceforex indications, usages and related health products lists
Buticef (Cefoperazone Sodium) Penta Labs
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CiNii Articles - NAKAMAKI Tsuyoshi
Clinical Efficacy of Fosfomycin in Combination with Sulbactam/Cefoperazone in the Treatment of Severe Infections Complicated to Blood Dyscrasia:Working Group of Kanto Combination Therapy for F0M+SBT/CPZ （1998 ...
T1551 | Semantic Scholar
The in vitro activity of cefoperazone (T-1551) against almost 9,000 recent clinical isolates at six institutions was tested and… Expand ...
Bacticid-CS from Tablets, Cefoperazone + Sulbactam - 3 Cef Novo 375 to Cadcef-S | DrugsUpdate India
Bacticid-CS from Tablets, Cefoperazone + Sulbactam - 3 Cef Novo 375 to Cadcef-S | Sulbactam is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Use of Bacticid-CS from Tablets, Pregnancy, lactation in childrens and special precautions for Bacticid-CS from Tablets, prices of Bacticid-CS from Tablets . Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene. In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals., drugsupdate.com - Indias leading online platform for Doctors and health care professionals. Updates on Drugs, news, journals, 1000s of videos, national and international events, product-launches and much more...Latest
Cefoperazone: A rare cause of thrombocytopenia<...
TY - JOUR. T1 - Cefoperazone. T2 - A rare cause of thrombocytopenia. AU - Avinash, A.. AU - Kunder, Sushil Kiran. AU - Magazine, Bharti Chogtu. AU - Bairy, K. L.. AU - Adiga, Shalini. PY - 2016. Y1 - 2016. N2 - Beta lactam antibiotics are one of the most commonly prescribed antibiotic drug classes in medical practice. Cephalosporins differ from other beta lactam antibiotics in both their structure and spectrum of action. Beta lactam antibiotics, in general, may cause platelet deficiency owing to their interference with normal platelet function. Cefoperazone, belonging to the group of 3rd generation cephalosporins, has been reported to cause hypoprothrombinemia and hence, bleeding manifestations. However, it is not known to alter platelet function and count at the routinely used therapeutic doses. This case report highlights a rare case of cefoperazone-induced thrombocytopenia.. AB - Beta lactam antibiotics are one of the most commonly prescribed antibiotic drug classes in medical practice. ...
Similar papers for Influence of an extended incubation period on values of minimum inhibitory concentrations of antibiotics in...
In 106 Stenotrophomonas maltophilia clinical strains the susceptibility to 19 kinds of antibiotics was tested by the broth dilution micromethod at 24 h and 48 h incubation. Isolated strains demonstrated the lowest frequency of resistance to cotrimoxazole (7.5% of resistant strains at 24 h incubation and 18.9% at 48 h), ofloxacin (13.2% and 30.2%), ciprofloxacin (19.8% and 50.9%) and to cefoperazone/sulbactam (20.8% and 37.7%). The smallest growth of the number of resistant strains after extended incubation was recorded in gentamicin (by 10.4%), ceftazidime (by 11.3%) and cotrimoxazole (by 11.4%). On the contrary, the largest growth of resistance was demonstrated in cefoperazone and ciprofloxacin (by 31.1%). Average values of the growth of minimum inhibitory concentrations (MICs) were lowest in ciprofloxacin and ofloxacin (2.3 times) and highest in piperacillin/tazobactam (4.5 times) and piperacillin (5.0 times). As far as the stability of MIC is concerned, the largest occurrence of strains with the MIC
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A retrospective study of antibiotic usage among in-patients of UTI in a tertiary care hospital<...
TY - JOUR. T1 - A retrospective study of antibiotic usage among in-patients of UTI in a tertiary care hospital. AU - Patel, Pratik. AU - Bairy, K. L.. AU - Amberkar, Mohan Babu. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Urinary tract infections are quite common in the community medical practice. The objective of our study was to know the prescription pattern of antibiotics used in the treatment of UTI. A retrospective observational study was conducted at Kasturba Hospital, Manipal, from 1st Jan 2012 to 31st Dec 2012. The case records of 500 patients of either sex who were admitted to Kasturba Hospital, Manipal with diagnosis of UTI were studied. Majority of patients were treated with single antimicrobial agent. Cephalosporins were most commonly prescribed group of antimicrobial agent followed by penicillins. Among cephalosporins, cefoperazone-sulbactam was most commonly prescribed drug followed by ceftriaxone. In penicillins, piperacillin-tazobactam was commonly prescribed drug. Among fluoroquinolones, ...
Previous research has shown antibiotics may increase the risk of immune-related diseases including inflammatory bowel disease (IBD) by disturbing the composition and functions of the gut microbiota. Although the use of antibiotics during the peripartum period (including both the preterm and post-natal periods) has been suggested as a risk factor for IBD development later in life, little is known about the possible underlying mechanisms.. A new rodent study, led by Dr. Eugene Chang from the Department of Medicine at the Knapp Centre for Biomedical Discovery at the University of Chicago (Chicago, USA), has found that antibiotics taken in pregnancy may lead to gut dysbiosis, immune dysfunction and increased IBD risk in genetically susceptible rat offspring.. The researchers examined the impact of the broad-spectrum antibiotic cefoperazone (CPZ) on both maternal and offspring gut microbiota when administered to dams during the peripartum period; they used the interleukin-10 (IL-10)-deficient mouse ...
Sulbactam - Drugs.com
Sulbactam is a medicine available in a number of countries worldwide. A list of US medications equivalent to Sulbactam is available on the Drugs.com website.
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Acinetobacter baumannii ATCC ® 43498™
Acinetobacter baumannii ATCC ® 43498™ Designation: S2 TypeStrain=False Application: Assay of cefoperazone Assay of sulbactam Quality control of cefoperazone/sulbactam
Aerobic Suscept: Gram Neg Resistant MIC Panel Urine/Non-Urine - Quest Diagnostics Nichols Institute of Valencia
CPT Code: 87186 Panel contains: Amikacin, Aztreonam, Cefoperazone, Cefotaxime, Ceftazidime, Chloramphenicol, Ciprofloxacin, Gentamicin, Mezlocillin, Norfloxacin, Piperacillin, Tobramycin, Trimethoprim/Sulfamethoxazole. If sending isolate, specify ID of organism and source of the specimen. SEND PURE CULTURE ONLY. If the isolate submitted is mixed, there will be no workup done pending clarification with the client. There will be separate charges for each organism that requires bacterial identification and sensitivities. If the isolate submitted needs identification, sensitivities will be delayed until the identification is complete ...
ybhR - Probable multidrug ABC transporter permease YbhR - Escherichia coli (strain K12) - ybhR gene & protein
Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane.
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Ceftriaxone + Sulbactam | Generic | Side effects | Usages | Composition
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Feature Article: Further Studies on Protein Skimmer Performance - Advanced Aquarist | Aquarist Magazine and Blog
Department of Chemistry, The Pennsylvania State University, University Park, PA 16802. Many factors contribute to the value of a skimmer to an aquarist, including quality of construction, size, footprint, noise level, ease of cleaning, energy efficiency of the pump, and of course, the ability to remove organic waste from aquarium water.
Studies on protein and nucleic acid metabolism in virus-infected mammalian cells. 5. The kinetics of synthesis of virus protein...
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IJMS | Free Full-Text | PseAAC-General: Fast Building Various Modes of General Form of Chous Pseudo-Amino Acid Composition for...
The general form pseudo-amino acid composition (PseAAC) has been widely used to represent protein sequences in predicting protein structural and functional attributes. We developed the program PseAAC-General to generate various different modes of Chous general PseAAC, such as the gene ontology mode, the functional domain mode, and the sequential evolution mode. This program allows the users to define their own desired modes. In every mode, 544 physicochemical properties of the amino acids are available for choosing. The computing efficiency is at least 100 times that of existing programs, which makes it able to facilitate the extensive studies on proteins and peptides. The PseAAC-General is freely available via SourceForge. It runs on both Linux and Windows.
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Adélovité - Wikipédia
Patria sem prevažne drobné motýle s výrazne dlhými a tenkými tykadlami, hlavne u samčekov. Tykadlá sú niekedy aj viac ako trikrát dlhšie, ako je dĺžka predných krídel. Rozpätie krídel sa najčastejšie pohybuje v rozmedzí 10 - 20 mm. Krídla sú často prekrásne tmavo, alebo pestro kovovo sfarbené. Oči samčekov bývajú zvyčajne veľké. Húsenice vytvárajú v listoch živných rastlín míny. Neskôr však list opúšťajú a vytvárajú si schránku. Imága sú aktívne hlavne cez deň, ale i v noci. Čeľaď opísal v roku 1851 Bruand. Oficiálne označenie čeľade v odbornej literatúre je potom Adelidae Bruand, 1851. Patrí do nadčeľade Incurvarioidea. Druhy motýľov z čeľade Adelidae sú na území Slovenska zaradené do viacerých rodov: Nemophora, Adela, Cauchas a Nematopogon. Na území Slovenska sa vyskytuje asi 30 druhov, ktoré sú zatriedené do vyššie uvedených štyroch rodov a dvoch podčeľadí: Adelinae a Nematopogoninae. ...
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z Opisthorchosis sú červy - to je plochá červy takzvané motolice.Spadajú do ľudského tela cez invazívne rýb.Tento druh červov sú nájdené v pečeni, slinivke brušnej a žlčníka.Môžu byť aktívne množiť v ľudskom tele po dobu asi 20 rokov.Podľa štatistík na svete je infikovaných asi 21 miliónov korú... Pokračovať V čítaní ...
Májové bábätka 2009 - Prežívame to isté - str. 29
lasenka skus ho cez den zobudit na kojenie a pripadne ho skus udrzat dlhsie hore. v noci ked sa aj zobudi, nezapinaj ziadne velke svetlo, najlepsie su take tie do zastrcky iba aby si na neho videla, snaz sa prebalovat co najmenej v noci, rozpravat na babo iba posepky a najlepsie je pritulit si ho k sebe v posteli a hladkat ho a take ukludnujuce ritualy si najst ...
Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics. ...
The chromosomally encoded beta-lactamase gene of Klebsiella oxytoca E23004, a strain resistant to cefoperazone and aztreonam, was cloned and expressed in Escherichia coli HB101. The molecular mass and pI of this enzyme were 28 kilodaltons and 7.4, respectively. Although the beta-lactamase of K. oxytoca hydrolyzed many cephalosporins, including broad-spectrum drugs, the nucleotide sequence and deduced amino acid sequence lacked homology with chromosomal class C beta-lactamase genes (ampC) of E. coli or Citrobacter freundii. Rather, about 45% nucleotide sequence homology and 40% deduced amino acid sequence homology were observed between the K. oxytoca beta-lactamase and TEM-1, a class A beta-lactamase which does not efficiently hydrolyze cephalosporins. Values of Km, relative Vmax, and relative Vmax/Km for the K. oxytoca beta-lactamase indicated that the enzyme is a penicillinase but that it can hydrolyze cefoperazone effectively and other broad-spectrum cephems weakly. Hence, the chromosomal ...
Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and...
Although most Lyme disease patients can be cured with antibiotics doxycycline or amoxicillin using 2-4 week treatment durations, some patients suffer from persistent arthritis or post-treatment Lyme disease syndrome. Why these phenomena occur is unclear, but possibilities include host responses, ant …
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ASTRAL is associated with leading national and multinational pharma companies like Pfizer, Ranbaxy, Zydus Cadila, Cipla, Orchid, Alembic, Sun Pharma, Blue Cross, Intas, Unique and Dr. Reddys, as the contract manufacturer for their products for domestic and export segments. The sterile dry powder Injectable division manufactures products comprising of Beta-Lactam and Cephalosphorin group of formulations, at the independent and dedicated facilities for each group. The major products of Cephalosphorin group are : Ceftazidime for injection, Cefuroxime for injection, Cefotaxime for injection, Cefoperazone for injection, Ceftriaxone for injection, Cefpirom for Injection, Cefoperazon Sodium and Salbactum Sodium for Injection. The products like Cephalothin for Injection, Cefepime Hydrochloride for Injection, Cefpiramide for Injection etc are streamlined for future introduction. The major products of Penicillin group are : Amoxicillin for Injection, Ampicillin for Injection, Cloxacillin for Injection, , ...
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Cepraz(cefoperazone): Infeksi sal napas, peritonitis & infeksi intra abdominal, septikemia bakterial, infeksi kulit & jar lunak, ISK, endometritis,
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Proteins of yeast cytoplasmic ribosomes were analyzed by two different methods of two-dimensional gel electrophoresis: run at pH 8.6 in 1-D1 and at pH 4.6 in 2-D (Method A); run at pH 5.0 in 1-D and i
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Understanding the function of complex biomacromolecular assemblies requires detailed knowledge of the structure and dynamics of the individual molecular components as well as of their interactions within complexes. Fluorescence based methods offer the possibility to measure protein properties and interactions with a high sensitivity and selectivity. The advent of bright and more photo-stable fluorescent dyes and an enormous methodical and technical improvement of high resolution fluorescence spectroscopy and microscopy enabled studies on proteins even at a single molecule level. Due to the fact that single molecule techniques provide information on the distribution of parameters characterizing the biological macromolecule, these methods are often the approach of choice to clarify and better understand the structure and function of proteins.. ...
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Pražská pesničkárka JANA ŠTEFLÍČKOVÁ sa ocitla na pódiu už ako desaťročná. A rovno ako objav pred mnohotisícovým davom na Porte. Za vyše dvadsať rokov odvtedy prešla všetkými možnými žánrami - od country cez šansón, jazz, blues až po autorskú pieseň. A že to robila na úrovni, by potvrdil aj John Mayall a jeho kapela, ktorým robila pred pár rokmi predskokanku na turné po Čechách.. ...
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The combination cefoperazone/sulbactam (Sulperazon) is available in many countries. Recently, its use in treating Acinetobacter ...
These include latamoxef (moxalactam), cefmenoxime, cefoperazone, cefamandole, cefmetazole, and cefotetan. This is thought to be ...
No differences are seen between using cefoperazone/sulbactam or ceftazidime to treat melioidosis, as both show similar death ... Meropenem, imipenem, and the cefoperazone-sulbactam combination (Sulperazone) are also effective. Intravenous amoxicillin- ...
However, unlike ceftazidime and cefoperazone, ceftriaxone does not have useful activity against Pseudomonas aeruginosa. It is ...
... cefoperazone, and other newer cephalosporins". Rev Infect Dis. The University of Chicago Press. 9 (4): 719-36. doi:10.1093/ ...
Modified charcoal cefoperazone deoxycholate (CCD) agar is a growth medium designed to isolate Campylobacters from feces. On CCD ... Identification of C. fetus species in infected animals or people is routinely performed by culture on blood or cefoperazone ... 1995-01-01), "Charcoal cefoperazone deoxycholate (CCD) agar - Modified", Progress in Industrial Microbiology, Culture Media for ...
"Cefoperazone-Sulbactam for Treatment of Intra-Abdominal Infections: Results from a Randomized, Parallel Group Study in India". ...
... cefoperazone/sulbactam), an antibiotic used for the treatment of urinary tract infections, which had $618 million in 2020 ...
Ciprofloxacin Ceftazidime Netilmicin Sulbactam or cefoperazone Meropenem Piperacillin/tazobactam Ampicillin/sulbactam Proteus ...
List of drugs: Cb-Ce
... cefoperazone (INN) ceforanide (INN) cefoselis (INN) Cefotan cefotaxime (INN) cefotetan (INN) cefotiam (INN) cefovecin sodium ( ...
ATCvet code QJ51
QJ51DB04 Cefazolin QJ51DB08 Cefapirin QJ51DB10 Cefacetrile QJ51DB90 Cefalonium QJ51DC02 Cefuroxime QJ51DD12 Cefoperazone ...
... cefoperazone, cefotetan, ceftriaxone, and latamoxef (moxalactam); thought to be due to common N-methylthiotetrazole metabolite ...
65 mg cefoperazone 1 −1 and 20% (v/v) fetal bovine serum in 5% CO2 atmosphere or in ambient air. Isolates were then grown at ...
... including cefoperazone, cefamandole and cefotetan, that have a N-methylthio-tetrazole moiety Griseofulvin, an oral antifungal ...
... amikacin piperacillin cefoperazone All tested strains have been found resistant to: penicillin ampicillin tetracycline ...
... and cefoperazone), ciprofloxacin (quinolones), trimethoprim/sulfamethoxazole (sulfonamides), chloramphenicol, most ...
... cefoperazone, cephalexin, enrofloxacin, lincomycin, oxytetracycline, miconazole, colistin, a combination of amoxicillin with ...
... or cefoperazone (Sulperazon) Tazobactam, usually combined with piperacillin (Zosyn and Tazocin) β-lactamase inhibitors without ...
ATC code J01
... combinations J01DD62 Cefoperazone and beta-lactamase inhibitor J01DD63 Ceftriaxone and beta-lactamase inhibitor J01DD64 ... Latamoxef J01DD07 Ceftizoxime J01DD08 Cefixime J01DD09 Cefodizime J01DD10 Cefetamet J01DD11 Cefpiramide J01DD12 Cefoperazone ...
Timeline of antibiotics
... cefoperazone/sulbactam 1986 - co-ticarclav (ticarcillin/clavulanic acid) 1987 - ampicillin/sulbactam 1987 - cefixime 1987 - ... cefoperazone 1981 - cefotiam 1981 - cefsulodin 1981 - latamoxef 1981 - netilmicin 1982 - ceftriaxone 1982 - micronomicin 1983 ...
... /sulbactam (Sulperazon) is a co-formulation with sulbactam. Cefoperazone has a broad spectrum of activity and has ... Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid. It is one of few ... Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta- ... "Cefoperazone (Cefobid) - The Antimicrobial Index Knowledgebase - TOKU-E". antibiotics.toku-e.com. Stork CM (2006). "Antibiotics ...
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin. The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out. This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts. The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong. There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation Extraction is more commonly ...
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. It is given by injection into a vein. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem. Use in pregnancy appears to be safe. It is in the carbapenem family of medications. Meropenem usually results in bacterial death through blocking their ability to make a cell wall. It is more resistant to breakdown β-lactamase producing bacteria. Meropenem was patented in 1983. It was approved for medical use in the United States in 1996. It is on the World Health ...
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria. Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. People treated initially with parenteral ...
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America. In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...
A set of multienzymes (peptide synthase CepA, CepB, and CepC) are responsible for assembling the heptapeptide. (Figure 2). The organization of CepA, CepB, and Cep C closely resembles other peptide synthases such as those for surfactin (SrfA1, SrfA2, and SrfA3) and gramicidin (GrsA and GrsB). Each peptide synthase activates codes for various amino acids to activate each domain. CepA codes for modules 1, 2, and 3. CepB codes for modules 4, 5, and 6, and CepC codes for module 7. The three peptide synthases are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis, and span 27 kb.. After the linear heptapeptide molecule is synthesized, vancomycin has to undergo further modifications, such as oxidative cross-linking and glycosylation, in trans[clarification needed] by distinct enzymes, referred to as tailoring enzymes, to become biologically active (Figure 3). To convert the linear heptapeptide, eight enzymes, open reading frames (ORFs) 7, 8, 9, 10, ...
Cefoperazone - Wikipedia
Cefoperazone/sulbactam (Sulperazon) is a co-formulation with sulbactam. Cefoperazone has a broad spectrum of activity and has ... Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid. It is one of few ... Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta- ... "Cefoperazone (Cefobid) - The Antimicrobial Index Knowledgebase - TOKU-E". antibiotics.toku-e.com. Stork CM (2006). "Antibiotics ...
Cefoperazone (Cefobid) use while Breastfeeding
Advice for mothers using Cefoperazone (Cefobid) while breastfeeding. Includes possible effects on breastfed infants and ... After 1 gram of cefoperazone given intravenously in 2 women, milk cefoperazone was 0.1 mg/L at 2 hours and 0.3 mg/L 3 hours ... Maternal Levels. After 1 gram of cefoperazone intravenously in 5 women, it was undetectable in milk in 2 women at any time up ... Limited information indicates cefoperazone produces low levels in milk that are not expected to cause adverse effects in ...
Cefoperazone Advanced Patient Information - Drugs.com
Detailed drug Information for Cefoperazone. Includes common brand names, drug descriptions, warnings, side effects and dosing ... Liver disease (cefoperazone and cefuroxime)-Cefoperazone needs to be given at a lower dose to people with liver disease. ... For cefoperazone. *For bacterial infections: *For injection dosage form: *Adults and teenagers-1 to 6 grams every twelve hours ... For patients receiving cefamandole, cefoperazone, or cefotetan by injection :. *Drinking alcoholic beverages or taking other ...
mCCDA - Modified Charcoal Cefoperazone Deoxycholate Agar | AcronymFinder
... mCCDA stands for Modified Charcoal Cefoperazone Deoxycholate Agar. mCCDA is defined as Modified Charcoal Cefoperazone ... How is Modified Charcoal Cefoperazone Deoxycholate Agar abbreviated? ... n.d.) Acronym Finder. (2021). Retrieved June 17 2021 from https://www.acronymfinder.com/Modified-Charcoal-Cefoperazone- ... S.v. "mCCDA." Retrieved June 17 2021 from https://www.acronymfinder.com/Modified-Charcoal-Cefoperazone-Deoxycholate-Agar-(mCCDA ...
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Cefoperazone (By injection). Cefoperazone (sef-oh-PER-a-zone). Treats infections caused by bacteria. This medicine is a ... You should not receive it if you had an allergic reaction to cefoperazone or any other cephalosporin medicine.. How to Use This ... Some medicines can affect how cefoperazone works. Tell your doctor if you are taking a blood thinner, including warfarin. ...
Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole...
We conducted a prospective randomized, double-blind, controlled study of cefoperazone-sulbactam (ratio, 1:1; cefoperazone 25 mg ... Cefoperazone-sulbactam plus cotrimoxazole might be used as an alternative to ceftazidime plus cotrimoxazole as treatment for ... Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole ... in the cefoperazone-sulbactam group versus 14% in the ceftazidime group. The crude difference in the mortality rate was 4%, but ...
Cefoperazone (By injection) | Drug Notes | Health Information | St. Luke's Hospital
Cefoperazone (By injection). Cefoperazone (sef-oh-PER-a-zone). Treats infections caused by bacteria. Belongs to a class of ... You should not use this medicine if you have ever had an allergic reaction to cefoperazone or any other cephalosporin medicine ... If you have severe diarrhea while taking cefoperazone, check with your doctor before taking medicine to stop the diarrhea. ...
Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and...
Drug - Cefina-SB (1g/0.5g) - 1 Injection (Cefoperazone - Combination of Generics ) Price List or Cost of Medication | Medindia
Cefoperazone - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Get up-to-date information on Cefoperazone side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about ... Cefoperazone is available in the following doses: *Cefoperazone 1 G Injectable Powder For Injection*Cefoperazone 10 G ... Cefoperazone falls into category B:. There are no well-done studies that have been done in humans with Cefoperazone. But in ... How was your experience with Cefoperazone?. First, a little about yourself. Male Female ...
Investigation Report on the Chinese Cefoperazone Sodium and Sulbactam Sodium Markets, 2016-2020 & 2021-2025 -...
... report has been added to ResearchAndMarkets.coms offering.Sales of the Cefoperazone Sodium and Sulbactam Sodium in China have ... Investigation Report on the Chinese Cefoperazone Sodium and Sulbactam Sodium Market 2021-2025 ... Prices of Cefoperazone Sodium and Sulbactam Sodium in China * Prices of Cefoperazone Sodium and Sulbactam Sodium in China by ... 1.1 Indications for Cefoperazone Sodium and Sulbactam Sodium 1.2 Development of Cefoperazone Sodium and Sulbactam Sodium in ...
Synergy of gatifloxacin with cefoperazone and cefoperazone-sulbactam against resistant strains of Pseudomonas aeruginosa
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Cefoperazone Sodium Solution for injection
Cefoperazone: A Rare Cause of Thrombocytopenia - MAHE Digital Repository
Cefoperazone - BioHarmony
Cefobid, Cefoperazone | ePharmapedia
Cefoperazone should be used in enterococcal infections with care and at doses that achieve satisfactory serum levels of ... Enterococcal Infections: Although cefoperazone has been shown to be clinically effective in the treatment of infections caused ... Despite this, cefoperazone therapy has resulted in clinical cures of enterococcal infections, chiefly in polymicrobial ... the majority of clinical isolates of enterococci tested are not susceptible to cefoperazone but fall just at or in the ...
CEFOPERAZONE & SULBACTAM 1500mg
Cefoperazone | Davis's Drug Guide
Find information on Cefoperazone in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, ... cefoperazone is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ... "Cefoperazone." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Emergency Central, emergency.unboundmedicine.com/ ... emergency/view/Davis-Drug-Guide/109020/all/cefoperazone. Vallerand AHA, Sanoski CAC, Quiring CC. Cefoperazone. Daviss Drug ...
Cefoperazone | Davis's Drug Guide
Find information on Cefoperazone in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, ... cefoperazone is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a subscription. ... "Cefoperazone." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral ... Davis-Drug-Guide/109020/all/cefoperazone. Quiring C, Sanoski CA, Vallerand AH. Cefoperazone. Daviss Drug Guide. F.A. Davis ...
Cefoperazone induced gastrointestinal haemorrhage. | IMSEAR
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Aged / Female / Humans / Male / Cefoperazone / Cellulitis / ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Aged / Female / Humans / Male / Cefoperazone / Cellulitis / ... Aged , Cefoperazone/adverse effects , Cellulitis/drug therapy , Cephalosporins/adverse effects , Female , Gastrointestinal ...
Cefoperazone Sulbactam injection Manufacturer,Exporter
Cefoperazone - Api Wholesaler, Supplier, Exporter
CephalosporinsAntibioticCefobidExporterSupplier500mgCell wall synthesisIndiaAntibiotics1000Allergic reaction to cefoperazoneDose2016PharmacokineticsVialCeftazidimeDavis's Drug GuideIndicationsInfectionsDoses of cefoperazoneConcentrations of cefoperazoneBacterialDosageSusceptibleAntibacterialSusceptibilityCombinationCefoxitinHypersensitivityNMTTInhibitor sulbactamExcreted in the bileRenalSerumEfficacy and SafetyInjectablePseudomonasPiperazine side chainResistantGramInjection IpForteAmikacin
- Unlike most cephalosporins, cefoperazone is principally excreted in the bile and elimination half-lives are approximately 2 hours in humans. (elephantcare.org)
- Cefoperazone, belonging to the group of 3rd generation cephalosporins, has been reported to cause hypoprothrombinemia and hence, bleeding manifestations. (manipal.edu)
- However, in vitro studies indicate that cefoperazone is less active on a weight basis than cefotaxime, ceftizoxime, and ceftriaxone against susceptible Enterobacteriaceae, and other cephalosporins (e.g., cefepime, cefotaxime, ceftazidime, ceftriaxone, ceftizoxime) generally are preferred when a parenteral cephalosporin is indicated for the treatment of infections known or suspected to be caused by Enterobacteriaceae. (antiinfectivemeds.com)
- aeruginosa and is more active against these organisms than many other available cephalosporins, cefoperazone is not generally considered a drug of choice for the treatment of infections caused by Ps. (antiinfectivemeds.com)
- Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. (tajgenerics.com)
- Indications for Cefoperazone Sodium + Sulbactam SodiumIt is a combination of third generation Cephalosporins Cefperazone sodium and Beta-lactamase inhibitor Sulbactam. (tajgenerics.com)
- Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid. (wikipedia.org)
- Cefoperazone is a third generation cephalosporin antibiotic , marketed by Pfizer under the name Cefobid , and also marked by pharco B international under the name of Cefazone . (thefullwiki.org)
- CEFOPERAZONE (sef oh PER a zone) is a cephalosporin antibiotic. (ahealthyme.com)
- Cefoperazone Sodium and Sulbactam Sodium is an injectable antibiotic. (pharmiweb.com)
- Cefoperazone is a common antibiotic drug used mainly to treat serious infections. (biomedcentral.com)
- Cefoperazone is a cephalosporin antibiotic that is active in vitro agai. (bertin-bioreagent.com)
- Cefoperazone is a cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram-negative bacteria, including β-lactamase strains (3-4 µg/ml inhibits 90% of S. aureus growth). (bertin-bioreagent.com)
- Cefoperazone is a semisynthetic, third generation cephalosporin antibiotic. (antiinfectivemeds.com)
- Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). (drugsupdate.com)
- Cefoperazone is a third-generation cephalosporin antibiotic used in the treatment of infections of skin and skin structures, respiratory tract, urinary tract, gynecological infections including gonorrhea, intraabdominal infections, and septicemia caused by susceptible micro organisms. (saintroylifescience.com)
- A well known cephalosporin antibiotic belonging to the third-generation, Cefoperazone is effective in the treatment of Pseudomonas bacterial infections. (nandlalbankatlal.com)
- Cefoperazone has NMTT side chain, whose free amount is released as soon as the antibiotic is consumed. (nandlalbankatlal.com)
- Cefoperazone is an antibiotic. (genixcare.in)
- About Cefoperazone Sodium A third generation cephalosporin antibiotic, Parenteral antibiotic. (tajgenerics.com)
- A report of "intermediate" suggests that the organism would be susceptible to sulbactam/cefoperazone if a higher dosage is used or if the infection is confined to tissues or fluids where high antibiotic levels are attained. (mims.com)
- Strategy of antibiotic therapy in SAP,De-escalate (cefoperazone+metronidazole) or Escalate (meropenem) therapy,which one is better. (clinicaltrials.gov)
- The tissue levels of both cefoperazone and cefoxitin were above the minimum inhibitory concentration of most sensitive pathogens several hours after a single prophylactic dose of either antibiotic. (elsevier.com)
- Cefoperazone is a semisynthetic cephalosporin antibiotic containing a piperazine side chain, which results in antipseudomonal activity. (elsevier.com)
- Cefoperazone is a third generation cephalosporin antibiotic, beta-lactam and inhibitor of cell wall synthesis. (medcraveonline.com)
- Prominent & Leading Exporter from Mumbai, we offer cefoperazone injection, piroxicam dispersible tablet, amikacin injection and ceftriaxone & tazobactam injection. (regalsalesagencies.com)
- Buy Cefoperazone Sodium CAS 62893-20-3, an API of Antibiotics, from A.H.A International, China leading supplier, factory & manufacturer, a Group company integrating production, R&D and sales. (wuxider.com)
- Cefoperazone, Cas#62893-19-0, 263-749-4 manufacturer / supplier in China, offering Product Export Cefoperazone (CAS#62893-19-0) with Kosher, Nutrition Enhancers with Beta-Hydroxybutyrate Calcium-CAS#586976-56-9, White Powder, High Purity 99% Creatinol Phosphate (CAS#6903-79-3) and so on. (made-in-china.com)
- Manufacturer of a wide range of products which include cefoperazone 1000mg sulbactam 500mg, pharma franchise in lakhisarai, pharma franchise in khagaria, pharma franchise in araria, pharma franchise in arwal and pharma franchise in aurangabad. (healthbiologicspharmafranchise.com)
Cell wall synthesis2
- Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms. (wikipedia.org)
- Mechanism of Action of Cefoperazone Sodium Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. (tajgenerics.com)
- Drug information on Cefina-SB (1g/0.5g) (Cefoperazone 1g + Sulbactam 0.5g) from Intra Labs India Pvt. (medindia.net)
- Among these drugs, one fibrate antilipemic (etofyllin clofibrate) and three β-lactam antibiotics (piperacillin, cefoperazone, and flucloxacillin) showed better trypanocidal effects (LC 50 range 15.8-26.1 μg/mL) in comparison with benznidazole and nifurtimox (LC 50 range 33.1-46.7 μg/mL). (mdpi.com)
- Risk of bleeding and hypoprothrombinaemia associated with NMTT side chain antibiotics: Using cefoperazone as a test case. (innovareacademics.in)
- Except for minocycline (33.5%) and sulbactam/cefoperazone (74.6%), these CRAB strains showed high resistance rates (>90%) to 16 tested antibiotics. (frontiersin.org)
Allergic reaction to cefoperazone1
- You should not receive it if you had an allergic reaction to cefoperazone or any other cephalosporin medicine. (limamemorial.org)
- After 1 gram of cefoperazone intravenously in 5 women, it was undetectable in milk in 2 women at any time up to 6 hours after the dose. (drugs.com)
- After 1 gram of cefoperazone given intravenously in 2 women, milk cefoperazone was 0.1 mg/L at 2 hours and 0.3 mg/L 3 hours after the dose. (drugs.com)
- both upper and lower extremities of tibiae and fibulae, The place which the tubercle occupies in pathological cefoperazone pediatric dose cases are met with, especially in children, where the tu- the obstruction and grows in unrestrained luxuriance. (microtas10.org)
- but is sometimes diffuse, especially when located in the cefoperazone dose cefoperazone uses uterus, as polypi, and they are then pedunculated. (microtas10.org)
- Store in a refrigerator & away from light.Effects of Missed Dosage of Cefoperazone SodiumTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose. (tajgenerics.com)
- Approximately 84% of the sulbactam dose and 25% of the cefoperazone dose administered with sulbactam/cefoperazone is excreted by the kidney. (mims.com)
- Most of the remaining dose of cefoperazone is excreted in the bile. (mims.com)
- Cefoperazone and cefoxitin concentrations were determined in serum and pelvic tissue samples obtained at various intervals after a 2-g intramuscular dose. (elsevier.com)
- In order to study the influence of chronic lobular hepatitis on the pharmacokinetics of cefoperazone, a dose of 1 g of cefoperazone was administered to 11 normal, healthy volunteers and 16 subjects with chronic lobular hepatitis. (elsevier.com)
- Attia KA, Nassar MW, Attar AAM (2016) Different Aspects in Partial Least Squares and Artificial Neural Network Models Used for the Analysis of Cefoperazone Sodium in Presence of its Alkaline Degradation Product. (medcraveonline.com)
- Pharmacokinetics - Cefoperazone is not absorbed after oral administration and must be given parenterally. (elephantcare.org)
- Hu, OYP, Tang, HSS & Chang, CLL 1994, ' The influence of chronic lobular hepatitis on pharmacokinetics of cefoperazone-a novel galactose single‐point method as a measure of residual liver function ', Biopharmaceutics & Drug Disposition , vol. 15, no. 7, pp. 563-576. (elsevier.com)
- For intravenous infusion, each vial of sulbactam/cefoperazone should be reconstituted with the appropriate amount of 5% dextrose, 0.9% sodium chloride injection or sterile water for injection as mentioned above and then further diluted to 20mL with the same solution followed by administration over 15-60 mins. (ubplexport.com)
- Each pack of Cefoperazone/Sulbactam-SD259-1VL contains 100 discs in vial. (biomall.in)
- Each vial contains Cefoperazone Sodium/Sulbactam Sodium equivalent to Cefoperazone 500 mg and Sulbactam 500 mg. (mims.com)
- Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. (nih.gov)
- Mortality rates were not significantly different between the 2 groups: 18% in the cefoperazone-sulbactam group versus 14% in the ceftazidime group. (nih.gov)
- Cefoperazone-sulbactam plus cotrimoxazole might be used as an alternative to ceftazidime plus cotrimoxazole as treatment for severe melioidosis. (nih.gov)
- The morphological responses of Pseudomonas aeruginosa to N-formimidoyl thienamycin, azthreonam, ceftazidime and cefoperazone were studied by transmission electron microscopy. (microbiologyresearch.org)
Davis's Drug Guide1
- cefoperazone is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
- Uses/Indications - Cefoperazone is used to treat serious infections, particularly against susceptible Enterobacteriaceae not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity). (elephantcare.org)
- Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. (wikipedia.org)
- Despite this, cefoperazone therapy has resulted in clinical cures of enterococcal infections, chiefly in polymicrobial infections. (epharmapedia.com)
- Cefoperazone should be used in enterococcal infections with care and at doses that achieve satisfactory serum levels of cefoperazone. (epharmapedia.com)
- We provide combination of Cefoperazone with Sulbactam to fight against stubborn infections,assure a safe zone in difficult situations,under brand name Zarazone. (salvavidaspharmaceutical.com)
- Cefoperazone is used in the treatment of intra-abdominal infections (including peritonitis), urinary tract infections, respiratory tract infections, skin and skin structure infections, septicemia, and gynecologic infections (including pelvic inflammatory disease [PID] and endometritis) caused by susceptible organisms. (antiinfectivemeds.com)
- Most clinicians state that cefoperazone generally should not be used in the treatment of infections caused by gram-positive bacteria when a penicillin or a first generation cephalosporin could be used. (antiinfectivemeds.com)
- therefore, cefoperazone should be used with caution in these infections and only at dosages that would be expected to achieve adequate concentrations of the drug. (antiinfectivemeds.com)
- aeruginosa are only susceptible to high concentrations of cefoperazone in vitro, an aminoglycoside should be used in conjunction with cefoperazone if the drug is used in the treatment of infections known or suspected to be caused by this organism. (antiinfectivemeds.com)
- Cefoperazone + Sulbactam is a promising combination for the treatment of infections due to certain cefoperazone resistant gram - ve bacilli, e.g. (systacareremedies.net)
- In severe or refractory infections - daily dosage of sulbactam / Cefoperazone may be increased up to 12 g of the 1 :2 ratio (i.e., 8 g cefoperazone activity). (systacareremedies.net)
- Cefoperazone And Sulbactam For Injection is a medicine used for the treatment of Bacterial Infections, Urinary Tract Infection, Skin Or Soft Tissue Infections, Respiratory Tract infection, Endometritis, Peritonitis, etc. (genixcare.in)
- CefoNix-SB 1.5g Injection contains two different medicines, Cefoperazone and Sulbactum, that work together to kill the bacteria that cause infections. (genixcare.in)
- Patients above 18 years of age with bacterial infections who received cefoperazone/sulbactam concurrent with Vitamin K were included. (innovareacademics.in)
- The clinical effectiveness and safety of Cefoperazone (CPZ, T-1551) and Cefazolin (CEZ) were compared in this randomized, double-blind multi-clinical study of 239 patients with respiratory tract infections. (elsevier.com)
- Cefoperazone (CPZ) is commonly used for infections caused by Gram-negative bacteria [1,2]. (medcraveonline.com)
Doses of cefoperazone1
- No teratogenic effects were demonstrated in studies in pregnant mice, rats, and monkeys given up to 10 times labeled doses of cefoperazone. (elephantcare.org)
Concentrations of cefoperazone1
- Although the serum and tissue concentrations of cefoperazone were much higher than those of cefoxitin, a greater portion of cefoxitin remained in the tissue. (elsevier.com)
- Typical Dosage for Cefoperazone Sodium Adults: 1g to 2gm I.M. or I.V. two times daily to three times daily. (tajgenerics.com)
- As sulbactam also binds with some penicillin-binding proteins, sensitive strains are also often rendered more susceptible to sulbactam/cefoperazone than to cefoperazone alone. (mims.com)
- A report from the laboratory of "susceptible" indicates that the infecting organism is likely to respond to sulbactam/cefoperazone therapy, and a report of "resistant" indicates that the organism is not likely to respond. (mims.com)
- The antibacterial component of sulbactam/cefoperazone is cefoperazone, a third generation cephalosporin, which acts against sensitive organisms during the stage of active multiplication by inhibiting biosynthesis of cell wall mucopeptide. (mims.com)
- Prior to initiation of cefoperazone therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests. (antiinfectivemeds.com)
- Cefoperazone may be started pending results of susceptibility tests but should be discontinued if the causative organism is found to be resistant to the drug. (antiinfectivemeds.com)
- The manufacturer recommends that, if cefoperazone is used concomitantly with an aminoglycoside, in vitro susceptibility tests should be performed to determine the combined activity of the drugs and renal function should be monitored, especially in patients with impaired renal function. (antiinfectivemeds.com)
- The following susceptibility ranges have been established for sulbactam/cefoperazone: See Table 1. (mims.com)
- Use of a susceptibility test disc containing 30 mcg of sulbactam and 75 mcg of cefoperazone is recommended. (mims.com)
- The following quality control limits are recommended for 30 mcg/75 mcg sulbactam/cefoperazone susceptibility discs. (mims.com)
- Criteria for disc susceptibility tests and quality control guidelines for the cefoperazone-sulbactam combination. (atcc.org)
- Cefina-SB is a combination of sulbactam and cefoperazone. (thefullwiki.org)
- CefoNix-SB 1.5g InjectionÂ is a combination of two medicines: Cefoperazone and Sulbactam. (genixcare.in)
- Sulbactam, a class A β-lactamase inhibitor, added to cefoperazone either at a fixed 8 mg/L level of sulbactam or at a level of fixed cefoperazone: sulbactam ratio (2:1) would constitute a combination form of cefoperazone/sulbactam, which has better activities against Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii than cefoperazone alone. (elsevier.com)
- The combination of sulbactam and cefoperazone is active against all organisms sensitive to cefoperazone. (mims.com)
- The combination cefoperazone/sulbactam (Sulperazon) is available in many countries. (wikipedia.org)
- The mean times (± standard deviation) of specimen collection were 188.5±61 and 185.5±55 min for cefoperazone and cefoxitin, respectively. (elsevier.com)
- The ratio of tissue concentration to serum concentration varied from 0.220 to 0.469 for cefoperazone and from 0.176 to 1.031 for cefoxitin. (elsevier.com)
- Bawdon, RE , Hemsell, DL & Guss, SP 1982, ' Comparison of cefoperazone and cefoxitin concentrations in serum and pelvic tissue of abdominal hysterectomy patients ', Antimicrobial agents and chemotherapy , vol. 22, no. 6, pp. 999-1003. (elsevier.com)
- Guss, S. P. / Comparison of cefoperazone and cefoxitin concentrations in serum and pelvic tissue of abdominal hysterectomy patients . (elsevier.com)
- Here, we report a case of hypersensitivity vasculitis associated with cefoperazone/sulbactam. (biomedcentral.com)
- A 13-year-old girl with appendicitis developed hypersensitivity vasculitis on the fifth day of cefoperazone/sulbactam therapy. (biomedcentral.com)
- Although hypersensitivity vasculitis has multiple causes, coexistence of hypersensitivity vasculitis and cefoperazone treatment, and the quite resolution of the disease after removal of the drug, strongly favours a causative relationship. (biomedcentral.com)
- To our knowledge, this is the first report of a hypersensitivity vasculitis associated with cefoperazone. (biomedcentral.com)
- Haemophilus influenzae: 0.12 - 0.25 µg/ml Staphylococcus aureus: 0.125 - 32 µg/ml Streptococcus pneumoniae: ≤0.007 - 1 µg/ml Cefoperazone contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. (wikipedia.org)
- Cefoperazone contains an N -methylthiotetrazole (NMTT or 1-MTT) side chain . (thefullwiki.org)
- In conclusion, appropriate composites of cefoperazone and β-lactamase inhibitor sulbactam may expand the clinical use if the pharmacokinetic optimization could be achieved in the human serum. (elsevier.com)
Excreted in the bile1
- Because cefoperazone is excreted in the bile, patients with significant hepatic disease or biliary obstruction may have their serum half-lives increase 2 - 4 times above normal. (elephantcare.org)
- The cefoperazone hepatic clearance, mean residence time, and renal clearance in hepatitis patients were significantly different from those of normal healthy volunteers, whereas the plasma protein binding was unaltered between the two groups. (elsevier.com)
- Cefoperazone was 90% bound to serum proteins. (tradeindia.com)
Efficacy and Safety1
- Aim: To determine the efficacy and safety of cefoperazone-sulbactam combined with amikacin in the treatment of febrile neutropenia in children with cancer. (cu.edu.tr)
- Pharmacology - Cefoperazone is a third generation injectable cephalosporin agent. (elephantcare.org)
- Chequerboard and time-kill methods were used to compare the in vitro efficacies of the combinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone-sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. (ovid.com)
- It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis Pharmacokinets of Cefoperazone Sodium Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not significantly metabolized inside the body. (tajgenerics.com)
Piperazine side chain1
- Chemistry - A third generation cephalosporin, cefoperazone sodium contains a piperazine side chain giving it antipseudomonal activity. (elephantcare.org)
- Daptomycin plus doxycycline and cefoperazone eradicated the most resistant microcolony form of B. burgdorferi persisters and did not yield viable spirochetes upon subculturing, suggesting durable killing that was not achieved by any other two or three drug combinations. (nih.gov)
- Cefoperazone/sulbactam (1:1 or 1:2) has greater in-vitro activity against most multidrug-resistant organisms (ESBL- and AmpC-producing Enterobacteriaceae and carbapenem-resistant A. baumannii except for carbapenem-resistant P. aeruginosa) than a 2:1 ratio. (elsevier.com)
- Some in-vitro studies showed that increasing sulbactam composites of cefoperazone/sulbactam had no effect on carbapenem-resistant P. aeruginosa, suggesting the presence of carbapenemases or AmpC overproduction that could not be overcome by increasing sulbactam levels to recover cefoperazone activity. (elsevier.com)
- Cefoperazone Injection Ip 500 Mg. (tradeindia.com)
- Briticef Forte Cefoperazone 1 g, sulbactam 0.5 g. (drugsupdate.com)
- Cefoperazone-sulbactam plus amikacin emp. (cu.edu.tr)