Cefmetazole
Cephamycins
Cefotetan
Ceftizoxime
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Carbapenems
Microbial Sensitivity Tests
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Klebsiella pneumoniae
beta-Lactamases
Vitamin K
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Vitamin K 1
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
Vitamin K Deficiency
Phenytoin
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Vitamins
Warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Vitamin A
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Vitamin K 2
Sub-minimal inhibitory concentrations of cefmetazole enhance serum bactericidal activity in vitro by amplifying poly-C9 deposition. (1/42)
Serum-resistant organisms grown in sub-minimal inhibitory concentrations (subMICs) of antibiotics in vitro may be rendered sensitive to complement-mediated, serum bactericidal activity. We measured 125I-C3 and 125I-C9 deposition on genetically serum resistant Salmonella montevideo SH5770 (SH5770) that was rendered serum sensitive by growth in sub-MICs of cefmetazole (CMZ), a parenteral, second generation, cephamycin-group antibiotic. Three times as much C3 and over six times as much C9 bound to SH5770 grown in one-fourth the MIC of CMZ compared to broth-grown bacteria. SDS-PAGE analysis and autoradiography showed that neither the ratio of C3b:iC3b (approximately 1:2.5) nor the nature of the C3-bacterial bond was changed by growing the organisms in CMZ. Large amounts of complement membrane attack complexes containing poly-C9 were seen only on CMZ-grown SH5770 by SDS-PAGE and autoradiography. Poly-C9 was also detected only on CMZ-grown bacteria by indirect immunofluorescence and ELISA using a murine monoclonal antibody directed against a neoantigen of poly-C9. Bacterial hydrophobicity increased after growth in CMZ, and transmission electron micrographs of CMZ-grown SH5770 showed cell wall disruption and blebbing. These results indicate that growth in subMICs of CMZ increases bacterial hydrophobic domains available for interacting with the membrane attack complex, C5b-9, allowing formation and stable insertion of bactericidal complexes containing poly-C9. (+info)Inhibition of biliary cholesterol and phospholipid secretion by cefmetazole. The role of vesicular transport and of canalicular events. (2/42)
A number of organic anions selectively inhibit the biliary secretion of cholesterol and phospholipids without affecting bile acid secretion. We studied the effect of cefmetazole, a third-generation cephalosporin, on biliary lipid secretion in the rat. Injection of cefmetazole at a dose of 200 mumol/kg body wt. induced a choleretic effect and a significant decrease in the biliary output of cholesterol and phospholipid, without changes in bile acid secretion. The decrease was more marked for cholesterol than for phospholipid secretion, with a significant decrease in their molar ratio in bile. The effects were apparently unrelated to an inhibition of intracellular vesicular transport because, after injection of horseradish peroxidase, both the time course and total amount secreted of the protein did not significantly differ between control animals and those receiving cefmetazole. The secretory rate of the lysosomal marker acid phosphatase was not affected by cefmetazole administration. Biliary outputs of the plasma-membrane enzymes alkaline phosphatase and gamma-glutamyltransferase were significantly decreased by the antibiotic. These results point to an effect of cefmetazole at the level of the canalicular membrane. (+info)Verification of cefmetazole and cefpodoxime proxetil contamination to other pharmaceuticals by liquid chromatography-tandem mass spectrometry. (3/42)
Cross-contamination is a critical issue for pharmaceutical manufacturing, especially for beta-lactam antibiotics. Thus, an analytical method for the simultaneous determination of beta-lactam antibiotics cefmetazole (CMZ) and cefpodoxime proxetil (CPDXPR) contaminants in non-beta-lactam pharmaceuticals was developed using high-performance liquid chromatography-tandem mass spectrometry. The developed method was found to be sensitive at the detection limit of 0.002 ppm for both compounds. Mean recoveries of CMZ and CPDXPR from olmesartan medoxomil (OLM) tablets were 96.7 to 102.2% and 88.9 to 94.2%, respectively. The developed method was successfully applied for the verification of CMZ and CPDXPR contamination to actually manufactured OLM tablets. (+info)Humanization of excretory pathway in chimeric mice with humanized liver. (4/42)
The liver of a chimeric urokinase-type plasminogen activator (uPA)(+/+)/severe combined immunodeficient (SCID) mouse line recently established in Japan could be replaced by more than 80% with human hepatocytes. We previously reported that the chimeric mice with humanized liver could be useful as a human model in studies on drug metabolism and pharmacokinetics. In the present study, the humanization of an excretory pathway was investigated in the chimeric mice. Cefmetazole (CMZ) was used as a probe drug. The CMZ excretions in urine and feces were 81.0 and 5.9% of the dose, respectively, in chimeric mice and were 23.7 and 59.4% of the dose, respectively, in control uPA(-/-)/SCID mice. Because CMZ is mainly excreted in urine in humans, the excretory profile of chimeric mice was demonstrated to be similar to that of humans. In the chimeric mice, the hepatic mRNA expression of human drug transporters could be quantified. On the other hand, the hepatic mRNA expression of mouse drug transporters in the chimeric mice was significantly lower than in the control uPA(-/-)/SCID mice. In conclusion, chimeric mice exhibited a humanized profile of drug excretion, suggesting that this chimeric mouse line would be a useful animal model in excretory studies. (+info)Susceptibilities of Mycobacterium fortuitum biovar. fortuitum and the two subgroups of Mycobacterium chelonae to imipenem, cefmetazole, cefoxitin, and amoxicillin-clavulanic acid. (5/42)
MICs of imipenem, cefoxitin, cefmetazole, and amoxicillin-clavulanic acid were determined against 100 strains of Mycobacterium fortuitum and 200 strains of Mycobacterium chelonae. Imipenem and cefmetazole were more active against M. fortuitum than cefoxitin was, and imipenem (which inhibited 39% of strains at 8 micrograms/ml) was the only beta-lactam active against M. chelonae subsp. chelonae. (+info)Comparative evaluation of the pharmacokinetics of N-methylthiotetrazole following administration of cefoperazone, cefotetan, and cefmetazole. (6/42)
The comparative pharmacokinetics and in vivo production of N-methylthiotetrazole (NMTT) were evaluated following administration of cefoperazone, cefotetan, and cefmetazole. In a randomized-crossover manner, 11 healthy male volunteers received single 2-g intravenous doses of each agent and serial blood and urine samples were collected. Concentrations of NMTT and the parent compound in plasma, urine, and the reconstituted antibiotic solution were determined by high-pressure liquid chromatography. The amounts of NMTT administered were 6.06 +/- 0.46, 14.4 +/- 0.87, and 17.4 +/- 1.06 mg for cefoperazone, cefotetan, and cefmetazole, respectively (P less than 0.05). The mean NMTT plasma concentration-time profiles following administration of each cephalosporin were markedly different. Six hours after dosing, NMTT concentrations in plasma following cefoperazone administration were higher than those following administration of cefmetazole and cefotetan. Urinary recoveries of NMTT averaged 137.0 +/- 37.1, 38.3 +/- 6.98, and 25.2 +/- 5.95 mg following administration of cefoperazone, cefotetan, and cefmetazole, respectively (P less than 0.01). The apparent amount of NMTT produced in vivo, calculated by subtracting the amount of NMTT administered from the amount of NMTT excreted in urine, was significantly lower following cefmetazole administration than after administration of cefoperazone and cefotetan (P less than 0.01). The discrepancy between in vitro NMTT production (cefmetazole greater than cefotetan greater than cefoperazone) and the amount of NMTT formed in vivo and excreted unchanged (cefoperazone greater than cefotetan greater than cefmetazole) suggests that in vivo production of NMTT is dependent on the disposition of the parent cephalosporin. These results further suggest that cephalosporins which undergo extensive biliary excretion, such as cefoperazone, are associated with the greatest amount of in vivo NMTT release, whereas cephalosporins which are primarily renally excreted, such as cefmetazole, are associated with the lowest in vivo production of NMTT. (+info)Effect of ampicillin, cefmetazole and minocycline on the adherence of Branhamella catarrhalis to pharyngeal epithelial cells. (7/42)
Using pharyngeal epithelial cells from a healthy adult and eight strains of Branhamella catarrhalis (B. catarrhalis) isolated from eight patients with respiratory infection the effect of subminimal inhibitory concentrations of cefmetazole, ampicillin and minocycline on adherence was examined. Cefmetazole-treated bacterial attachment (44 +/- 28; mean +/- S.D.) decreased significantly (p less than 0.05) compared to the control (84 +/- 27). Statistically no significant difference in adherence was found between ampicillin-treated bacteria (63 +/- 36) and the control (95 +/- 40) or minocycline-treated bacteria (91 +/- 39) and the control (109 +/- 40). Large bacteria was observed after cefmetazole and ampicillin treatment. In addition to diplococci, tetrads were observed after cefmetazole treatment. Significant correlation between the MICs and adherence ability was not found. The results suggests that these three antibiotics were not responsible for the increase in B. catarrhalis infection by increasing adherence ability. (+info)A successfully treated case of Vibrio vulnificus septicemia with shock. (8/42)
Vibrio vulnificus infection often causes serious or fatal disease. Recently, in Japan there have been numerous reports of Vibrio vulnificus infection. Here, we report a successfully treated case of Vibrio vulnificus septicemia with shock, disseminated intravascular coagulation (DIC) and necrotizing cellulitis in a middle-aged heavy drinker with chronic alcoholic liver disease. On reviewing 38 cases in Japan including ours, the overall mortality rate was 68%. Although the incidence is relatively low, it is recommended to warn patients in the high risk category, such as liver disease patients, to avoid raw fish and shellfish and limit sea water exposure. (+info)
In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae<...
Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing carbapenem-resistant...
Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical...
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The effects of cephem antibiotics and related compounds on the aldehyde dehydrogenase in rat liver mitochondria<...
Enhanced Warfarin Response and Antibiotics
Efficacy of combination therapy against mrsa in ibaraki prefecture<...
Mycobacterium goodii - Wikipedia
Severe Clostridium difficile Enteritis after Laparoscopic Lower Anterior Resection - SAGES Abstract Archives
Cefotetan
Vitamin K | University of Maryland Medical Center
Cefotetan | definition of cefotetan by Medical dictionary
Drug Interactions With Cefotetan
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Second Generation Anti-anaerobe Cephalosporins
What is the systemic clearance of Tramadol 50 mg?
Cephalosporin
Cefmetazole and cefoxitin are classed as third-generation cephems. Flomoxef and latamoxef are in a new class called oxacephems ... These include latamoxef (moxalactam), cefmenoxime, cefoperazone, cefamandole, cefmetazole, and cefotetan. This is thought to be ...
Cephamycin
Benlloch M, Torres A, Soriano F (October 1982). "Cefmetazole (CS-1170): a new cephamycin with activity against gram-negative ... Cephamycins include: Cefoxitin Cefotetan Cefmetazole Oreste A. Mascaretti (2003). Bacteria Versus Antibacterial Agents: An ...
Mycobacterium goodii
... doxycycline and tobramycin and variable susceptibility to cefmetazole, cefoxitin and clarithromycin. They are resistant to ...
Mycobacterium wolinskyi
... variably susceptible to cefmetazole, cefoxitin, chloramphenicol and clarithromycin, and resistant to isoniazid, rifampin and ...
List of drugs: Cb-Ce
... cefmetazole (INN) cefminox (INN) Cefobid cefodizime (INN) cefonicid (INN) cefoperazone (INN) ceforanide (INN) cefoselis (INN) ...
List of MeSH codes (D02)
... cefmetazole MeSH D02.065.589.099.249.250.199 - cefotetan MeSH D02.065.589.099.249.250.222 - cefoxitin MeSH D02.065.589.099.374 ...
Disulfiram-like drug
... cefmetazole, cefonicid, cefoperazone, cefotetan, ceftriaxone, and latamoxef (moxalactam); thought to be due to common N- ...
ATC code J01
Cefamandole J01DC04 Cefaclor J01DC05 Cefotetan J01DC06 Cefonicide J01DC07 Cefotiam J01DC08 Loracarbef J01DC09 Cefmetazole ...
Timeline of antibiotics
... cefmetazole 1980 - cefotaxime 1980 - piperacillin 1981 - co-amoxiclav (amoxicillin/clavulanic acid) 1981 - cefoperazone 1981 - ...
Cefmetazole
... is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing ... Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins. The chemical structure of ... "Cefmetazole, free acid Susceptibility and Concentration Range (μg/ml) Minimum Inhibitory Concentration (MIC) Data" (PDF). The ... cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the ...
Cefuroxime axetil
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/ ...
Benzylpenicillin
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...
Meropenem
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...
Cefetamet
InChI=1S/C14H15N5O5S2/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/ ...
Nafcillin
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
Phenoxymethylpenicillin
Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[9][10] Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[9][10]. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[11] People treated initially with parenteral ...
Ceftolozane
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America.[8] In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...
Vancomycin
A set of multienzymes (peptide synthase CepA, CepB, and CepC) are responsible for assembling the heptapeptide. (Figure 2). The organization of CepA, CepB, and Cep C closely resembles other peptide synthases such as those for surfactin (SrfA1, SrfA2, and SrfA3) and gramicidin (GrsA and GrsB).[41] Each peptide synthase activates codes for various amino acids to activate each domain. CepA codes for modules 1, 2, and 3. CepB codes for modules 4, 5, and 6, and CepC codes for module 7. The three peptide synthases are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis, and span 27 kb.[41]. After the linear heptapeptide molecule is synthesized, vancomycin has to undergo further modifications, such as oxidative cross-linking and glycosylation, in trans[clarification needed] by distinct enzymes, referred to as tailoring enzymes, to become biologically active (Figure 3). To convert the linear heptapeptide, eight enzymes, open reading frames (ORFs) 7, 8, 9, 10, ...
Cefminox
InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 ‹See TfM› ...
Cefdinir
... (SEF-di-nir) is a third-generation oral cephalosporin antibiotic sold under the brand names Cefzon and Omnicef. As of 2008, cefdinir, as Omnicef, was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1] Cefdinir is structurally similar to cefixime. It was discovered by Fujisawa Pharmaceutical Co., Ltd. (now Astellas) and introduced in 1991 under the brand name Cefzon.[2][3] Warner-Lambert licensed this cephalosporin for marketing in US from Fujisawa.[4] Abbott obtained U.S. marketing rights to Omnicef (cefdinir) in December 1998 through an agreement with Warner-Lambert Company.[5] It was approved by FDA on Dec 4, 1997.[6] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark, Cefdair by Xalra Pharma and Cefdiel by Ranbaxy. ...
Ceftolozane/tazobactam
Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death. Ceftolozane is an inhibitor of PBPs of Pseudomonas aeruginosa (e.g. PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).[6][7] Tazobactam is a potent β-lactamase inhibitor of most common class A and C β-lactamases. Tazobactam has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins; however, it is an irreversible inhibitor of some β-lactamases (certain penicillinases and cephalosporinases) and can covalently bind to some chromosomal and plasmid-mediated bacterial beta-lactamases.[6] The addition of tazobactam strengthens the therapeutic response to ceftolozane, giving it the ability to treat a broader range ...
Cefprozil
... is a second-generation cephalosporin antibiotic. It can be used to treat ear infections, skin infections, and other bacterial infections.[citation needed] It comes as a tablet and as a liquid suspension. Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins. It was patented in 1983 and approved for medical use in 1992.[2] ...
Imipenem/cilastatin
... has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...
Stampa:Penicillin
Cefmetazole) • carbacephem (Loracarbef). ...
اسپکتینومایسین - ویکیپدیا
InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1 ...
سفتریاکسون - ویکیپدیا
سفتریاکسون (آیوپاک آدی: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-,2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, اینگیلیسجه: Ceftriaxone, (چینجه:頭孢曲松)، عربجه: سيفترياكسون، روسجا: Цефтриаксон) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۵۵۴٫۵۸ دیر. نیمه عمر یا یاریلانما سۆرعتی ۵٫۸-۸٫۷ ساعات زامان آپاریر و آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
سیکلوسرین - ویکیپدیا
سیکلوسرین (آیوپاک آدی: (R)-4-Amino-1,2-oxazolidin-3-one, اینگیلیسجه: Cycloserine, عربجه: سيكلوسيرين، روسجا: Циклосерин) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۱۰۲٫۰۹۲ دیر. متابولیسمی قاراجییرده باش وئریر. سیکلوسرین آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
سیلور سولفادیازین - ویکیپدیا
سیلور سولفادیازین (آیوپاک آدی: Silver [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide, اینگیلیسجه: Silver sulfadiazine, (چینجه:磺胺嘧啶银)) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۳۵۷٫۱۴ دیر. سیلور سولفادیازین آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
বিটা ল্যাক্টাম - উইকিপিডিয়া
Cefmetazole) • carbacephem (Loracarbef) ...
Cefmetazole - Wikipedia
Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing ... Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins. The chemical structure of ... "Cefmetazole, free acid Susceptibility and Concentration Range (μg/ml) Minimum Inhibitory Concentration (MIC) Data" (PDF). The ... cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the ...
Cefmetazole medication - Answers on HealthTap
Bensinger on cefmetazole medication: Cefmetazole (Zefazone) is a cephamycin antibiotic. For potential adverse reactions see: ... https://www.drugs.com/sfx/cefmetazole-side-effects.html ... What is the definition or description of: Cefmetazole allergy? ... Cefmetazole (Definition) Cefmetazole is a second generation cephalosporin which is a kind of cephalosporin type drug (anti- ... Cefmetazole allergy: Cefmetazole (Zefazone) is a cephamycin antibiotic. For potential adverse reactions see: https://www.drugs. ...
cefmetazole epitope - Immune Epitope Database (IEDB)
Global and Chinese Cefmetazole Sodium for Injectio Industry, 2017 Market Research Report, Trends, Share, Size Research Report
Global and Chinese Cefmetazole Sodium for Injectio Industry, 2017 Market Research Report Size and Share Published in 2017-07-21 ... 1.2 Development of Cefmetazole Sodium for Injectio Industry. 1.3 Status of Cefmetazole Sodium for Injectio Industry. Chapter ... 8.3 Effects to Cefmetazole Sodium for Injectio Industry. Chapter Nine Market Dynamics of Cefmetazole Sodium for Injectio ... 2.1 Development of Cefmetazole Sodium for Injectio Manufacturing Technology. 2.2 Analysis of Cefmetazole Sodium for Injectio ...
Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing carbapenem-resistant...
We assessed the efficacy of combination therapy with meropenem (MEM) and cefmetazole (CMZ) against Imipenemase (IMP)-producing ... Abe, R., Hagiya, H., Akeda, Y. et al. Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing ... In a previous study, we demonstrated the in vitro efficacy of the combination of meropenem (MEM) and cefmetazole (CMZ) against ... Doi A, Shimada T, Harada S, Iwata K, Kamiya T. The efficacy of cefmetazole against pyelonephritis caused by extended-spectrum ...
BenPharmas. Cefmetazole sodium Impurity 4
Cefmetazole Sodium - 56796-39-5 - Discovery Fine Chemicals
Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding proteins (PDPs) other than ... Cefmetazole Sodium. Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding ... Cefmetazole is used to study protein mediated transport of antibiotics.. Product Details. Category. Antibiotics & ... Send us your enquiry for Cefmetazole Sodium. We offer custom pack sizes at special prices. We aim to respond to your enquiry ...
Prophylaxis in caesarean section with cefmetazole and cefoxitin<...
18.5 degree hours in the cefmetazole group and 7.5 ± 11.7 degree hours in the cefoxitin group. Cefmetazole to be equivalent to ... 18.5 degree hours in the cefmetazole group and 7.5 ± 11.7 degree hours in the cefoxitin group. Cefmetazole to be equivalent to ... 18.5 degree hours in the cefmetazole group and 7.5 ± 11.7 degree hours in the cefoxitin group. Cefmetazole to be equivalent to ... 18.5 degree hours in the cefmetazole group and 7.5 ± 11.7 degree hours in the cefoxitin group. Cefmetazole to be equivalent to ...
Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer...
Few studies have reported the dosage of cefmetazole (CMZ) for intraoperative antimicrobial prophylaxis in patients underwent ... Observed cefmetazole serum concentration from 23 patients. The plots were showed after the first dose (●), the second dose (○ ... Cefmetazole (CMZ) is a cephamycins antibiotics developed in Japan that has high antibacterial activity against gram-negative ... Assay of cefmetazole concentrations. Serum CMZ concentrations were measured by high-performance liquid chromatography (HPLC). ...
2013 Interpretive Criteria for Neisseria gonorrhoeae Susceptibility Testing - STD information from CDC
In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae<...
Fingerprint Dive into the research topics of In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against ... In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae. / Hagiya ... In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae. In: ... In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae. Microbial ...
Table 6 - Antibacterial Household Products: Cause for Concern - Volume 7, Number 7-June 2001 - Emerging Infectious Diseases...
Use of Direct Hemoperfusion with Polymyxin B-Immobilized Fiber for the Treatment of Septic Shock Complicated with Lemierre...
Neuroprotection with Beta-Lactam Compounds - Johns Hopkins University
Cefmetazole for bacteremia caused by ESBL-producing enterobacteriaceae comparing with carbapenems | BMC Infectious Diseases |...
... which gradually changed over time favoring the use of cefmetazole instead (p = 0.002). Cefmetazole may be safely given to ... Five patients in the carbapenem group and one patient in the cefmetazole group died during the observation period (p = 0.24). ... Although cephamycins such as cefoxitin, cefmetazole or cefotetan are effective against ESBL-producers in vitro, there are few ... had increased severity in the Pittsburgh Bacteremic score than the group that received cefmetazole therapy, (1.5 ± 1.5 vs 2.5 ...
NCI Drug Dictionary - National Cancer Institute
Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant...
... and the mechanism of synergistic effect between cefmetazole and fosfomycin was also studied. Cefmetazole inhibited the growth ... Combined administration of cefmetazole with fosfomycin at a ratio of 1:1 against systemic MR S. aureus infections with mice ... Exposure of cefmetazole plus fosfomycin to exponentially growing cultures at a concentration at which both antibiotics had no ... Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant ...
Metallo-β-Lactamase-Producing Gram-Negative Bacilli: Laboratory-Based Surveillance in Cooperation with 13 Clinical Laboratories...
Possible Interactions with: Vitamin K | University of Maryland Medical Center
SLC15A1 - Solute carrier family 15 member 1 - Homo sapiens (Human) - SLC15A1 gene & protein
mrcA - Penicillin-binding protein 1A - Escherichia coli (strain K12) - mrcA gene & protein
Abbreviations and Conventions | Journal of Clinical Microbiology
Statistical analysis of data is a crucial component of scientific publication. Authors who are unsure of proper statistical analysis should have their manuscripts checked by a qualified statistician.. The following is a list of important items that must be considered before manuscript submission. Deficiencies in any of these areas may delay review and/or publication.. (i) The same reference (gold) standard should be used for all samples for a given analyte. That reference standard might include more than one test, but it should be used and interpreted consistently for all samples. The reference standard should not include results from the test that is under study.. (ii) Do not use sensitivity or specificity to describe results which compare a new test to a non-reference standard. Use the terms positive percent agreement and negative percent agreement for these results, as recommended by the FDA guidance document Statistical Guidance on Reporting Results from Studies Evaluating ...
Vitamin K | University of Maryland Medical Center
Warfarin Drug Interactions
Penicillin-binding protein 1A - DrugBank
Citrobacter Peritoneal Dialysis Peritonitis: Rare Occurrence with Poor Outcomes
The rate of resistance to cefmetazole was 27%, with another 27% showing intermediate resistance to cefmetazole. None of the ... Of the Citrobacter isolates from all episodes, 54% were resistant to cefazolin, and only 18% were susceptible to cefmetazole. ... cefazolin and cefmetazole than C. freundii in our study. s. In addition, ineffective empirical antibiotics are associated with ...
![Higuchi H[au] - PubMed - NCBI](data:image/png;base64,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)
Higuchi H[au] - PubMed - NCBI
Appleman MD[au] - PubMed - NCBI
Edward Keller productsCefotetan1
- Some?such as moxalactam, cefoperazone, cefamandole, cefotetan, and cefmetazole?appear to inhibit the formation of clotting factors and indirectly increase the effect of warfarin. (pharmacytimes.com)
Cefoxitin5
- A prospective, randomized, open comparison of three 1 g doses of cefmetazole with three 2 g doses of cefoxitin for non-elective Caesarean section was performed. (elsevier.com)
- The incidence was the same in both groups, 5/50 (10%) in the cefmetazole group and 2/19 (10.5%) in the cefoxitin group. (elsevier.com)
- Febrile morbidity, as reflected in the fever index, was not significantly different between the groups, 10.2 ± 18.5 degree hours in the cefmetazole group and 7.5 ± 11.7 degree hours in the cefoxitin group. (elsevier.com)
- Cefmetazole to be equivalent to cefoxitin in reducing post-Caesarean section endomyometritis. (elsevier.com)
- Group IV (cephamycins): eg cefoxitin, moxolactam, cefmetazole. (vetstream.com)
Cefoperazone2
- Unlabeled test compounds, pravastatin, rosuvastatin, valsartan, cefmetazole, and cefoperazone exhibited varying degrees of in vitro biliary excretion in the cumulative uptake study using SCRH. (aspetjournals.org)
- Haisco Pharma's firstaid drugs comprise cefotene hydrochloride, sodium fusidate, cefmetazole sodium, cefmenoxime hydrochloride and cefoperazone sodium tazobactam sodium. (bioportfolio.com)
Efficacy of meropenem1
- We assessed the in vitro efficacy of meropenem (MEM) and cefmetazole (CMZ) combination treatment against bla KPC-2 -positive Enterobacteriaceae, in comparison with that of double-carbapenem therapy using ertapenem (ERT). (elsevier.com)
Cephamycin1
- Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins. (wikipedia.org)
Cephalosporins1
- The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. (wikipedia.org)
Cefazolin2
- The binding affinity of cefmetazole for the penicillin-binding protein 2' fraction specific for MR S. aureus was higher than that of methicillin, cloxacillin, cefazolin, and cefotaxime. (core.ac.uk)
- Of the Citrobacter isolates from all episodes, 54% were resistant to cefazolin, and only 18% were susceptible to cefmetazole. (medsci.org)
Antibiotics6
- Cefmetazole is used to study protein mediated transport of antibiotics. (discofinechem.com)
- Cefmetazole (CMZ) is a cephamycin's antibiotics developed in Japan that has high antibacterial activity against gram-negative and anaerobic bacteria. (biomedcentral.com)
- Exposure of cefmetazole plus fosfomycin to exponentially growing cultures at a concentration at which both antibiotics had no bactericidal effect when given alone exerted bactericidal action. (core.ac.uk)
- Till POD2, we used prophylactic antibiotics: cefmetazole 2g/day. (sages.org)
- Other antibiotics were present at mean concentrations below 15 ng L −1 , except cefmetazole, present at a mean concentration of 35.6 ng L −1 . (springer.com)
- 2006. There is no effective M. immunogenum treatment, due to the resistance of the bacterium to a wide variety of antibiotics such as cefmetazole, ciprofloxacin, and doxycycline (Jaén-Luchoro et al. (kenyon.edu)
Sodium salt1
- Through the experiments explained below, we used meropenem trihydrate (Tokyo Chemical Industry, Japan, Tokyo) and cefmetazole sodium salt (Sigma-Aldrich, Saint Louis, MO, United States) as antibiotic agents. (biomedcentral.com)
Cephalosporin1
- Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. (wikipedia.org)
Fosfomycin5
- Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus. (core.ac.uk)
- In vitro and in vivo antibacterial activities of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant (MR) strains of Staphylococcus aureus were investigated, and the mechanism of synergistic effect between cefmetazole and fosfomycin was also studied. (core.ac.uk)
- the antibacterial activity of cefmetazole against these strains was enhanced approximately 4 times with the addition of fosfomycin at a concentration of 1.56 micrograms/ml. (core.ac.uk)
- A synergy experiment in vitro was performed by checkerboard titration with Mueller-Hinton agar plates containing various concentrations and ratios of cefmetazole and fosfomycin. (core.ac.uk)
- Combined administration of cefmetazole with fosfomycin at a ratio of 1:1 against systemic MR S. aureus infections with mice showed an excellent therapeutic efficacy as compared with administration of either antibiotic alone. (core.ac.uk)
Free acid1
- Cefmetazole, free acid Susceptibility and Concentration Range (μg/ml) Minimum Inhibitory Concentration (MIC) Data" (PDF). (wikipedia.org)
Antimicrobial1
- Few studies have reported the dosage of cefmetazole (CMZ) for intraoperative antimicrobial prophylaxis in patients underwent surgery for colorectal cancer. (biomedcentral.com)
Enterobacteriaceae1
- We assessed the efficacy of combination therapy with meropenem (MEM) and cefmetazole (CMZ) against Imipenemase (IMP)-producing CRE, using the checkerboard method and time-killing assay on 13 Enterobacteriaceae isolates harboring bla IMP-1 (4 Enterobacter hormaechei , 5 Escherichia coli , and 4 Klebsiella pneumoniae isolates) and 13 isolates harboring bla IMP-6 (8 E. coli and 5 K. pneumoniae isolates). (biomedcentral.com)
Japan1
- 5.2 Market Competition of Cefmetazole Sodium for Injectio Industry by Country (USA, EU, Japan, Chinese etc. (researchmoz.us)
Status1
- The report provides key statistics on the market status of the Cefmetazole Sodium for Injectio manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (researchmoz.us)
Current1
- The 'Global and Chinese Cefmetazole Sodium for Injectio Industry, 2012-2022 Market Research Report' is a professional and in-depth study on the current state of the global Cefmetazole Sodium for Injectio industry with a focus on the Chinese market. (researchmoz.us)
Study1
- Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding proteins (PDPs) other than PBP2 on bacterial cell wall mucopeptide synthesis. (discofinechem.com)
Include1
- We value your input so if you have suggestions regarding new applications for Cefmetazole Sodium email us and we will include your contribution on the website. (discofinechem.com)
Focus1
- Cefmetazole was not effective, and there was no focus of infection. (springer.com)
