A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Semisynthetic broad-spectrum cephalosporin.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Substances that reduce the growth or reproduction of BACTERIA.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Inflammation of the LARYNGEAL MUCOSA, including the VOCAL CORDS. Laryngitis is characterized by irritation, edema, and reduced pliability of the mucosa leading to VOICE DISORDERS such as APHONIA and HOARSENESS.
Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.
Inflammation of the throat (PHARYNX).
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)
The giving of drugs, chemicals, or other substances by mouth.
A cephalosporin antibiotic.
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.
Inflammation of the middle ear with a clear pale yellow-colored transudate.
A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
One of the PENICILLINS which is resistant to PENICILLINASE.
A plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. Some members contain triterpenoid saponins.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION).
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
A genus of gram-positive, microaerophilic, rod-shaped bacteria occurring widely in nature. Its species are also part of the many normal flora of the mouth, intestinal tract, and vagina of many mammals, including humans. Pathogenicity from this genus is rare.
A genus of gram-positive, anaerobic, coccoid bacteria that is part of the normal flora of humans. Its organisms are opportunistic pathogens causing bacteremias and soft tissue infections.
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Organizational activities previously performed internally that are provided by external agents.
Cultivated plants or agricultural produce such as grain, vegetables, or fruit. (From American Heritage Dictionary, 1982)
A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.
A genus of gram-positive bacteria in the family Cellulomonadaceae.
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
A publication issued at stated, more or less regular, intervals.
Class of BACTERIA with diverse morphological properties. Strains of Actinobacteria show greater than 80% 16S rDNA/rRNA sequence similarity among each other and also the presence of certain signature nucleotides. (Stackebrandt E. et al, Int. J. Syst. Bacteriol. (1997) 47:479-491)
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin. (1/116)

AIMS: The aim of this study was to determine the potential influence of variables such as the cell content in the fluid, and serum levels, on the concentrations of ceftibuten, cefixime and azithromycin in the middle ear fluid of patients suffering from acute otitis media. METHODS: This randomized, open study compared the penetration of ceftibuten (9 mg kg(-1) 18 patients), cefixime (8 mg kg(-1), 16 patients) and azithromycin (10 mg kg(-1) 16 patients) into the intracellular and extracellular compartments of middle ear fluid of 50 paediatric patients (aged 8-14 years) with acute otitis media. Middle ear fluid was extracted by tympanocentesis 4, 12 and 24 h after dosing and divided into two fractions: with cells (as collected) (C+) and cell-free (C-). Antibiotics were assayed in C+ and C- samples by h.p.l.c. RESULTS: Ceftibuten achieved greater penetration into middle ear fluid than cefixime and azithromycin. Higher concentrations of ceftibuten (CTB) and cefixime (CFX) were found in the C- fraction (CTB: 4h 13.3+/-1.86; 12h 4.7+/-1.18; 24h 0.5+/-0.2. CFX: 4h 3.2+/-1.4; 12h 1.5+/-0.5; 24h>(0.1 mgl(-1)) than in the C+ fraction (CTB:4 h 8.4+/-4.3; 12 h 2.88+/-1.19; 24 h 0.3+/-0.27. CFX: 4 h 1.2+/-0.6; 12 h 0.8+/-0.2; 24 h>0.1 mg l(-1)) at the each time point, while the opposite was true for azithromycin (C-: 4 h 0.11+/-0.04; 12 h 0.12+/-0.08; 24 h 0.23+/-0.12. C+: 4 h 0.38+/-0.24; 12 h 0.9+/-0.03; 24 h 1.05+/-0.3 mg l(-1)). CONCLUSIONS: This study demonstrates that the penetration of antibiotics into the middle ear fluid is influenced by its serum concentrations as well as by the cell content in the fluid. Ceftibuten achieved higher middle ear fluid concentrations than cefixime in C+ and C- fractions at all time points. Both ceftibuten and cefixime concentrations are negatively influenced by the cell content in the fluid. In contrast the concentration of azithromycin to the middle ear fluid is positively influenced by the cell content in the fluid.  (+info)

Intestinal absorption of cefixime in rats. (2/116)

AIM: To study the intestinal absorption characters of cefixime (Cef) and the factors affecting Cef absorption. METHODS: A rat intestine loop in situ technique was used to investigate the disappearance rate of Cef from the intestine. Cef concentration in the flux was measured by the reversed phase HPLC. RESULTS: Cef was mainly absorbed from the upper part of the intestine. Its disappearance rate was apparently pH-dependent [(5.8 +/- 0.6) nmol.h-1/(g wet tissue) at pH 7.4, (8.9 +/- 1.4) nmol.h-1/(g wet tissue) at pH 5.0, P < 0.05)]. The uptake rate of Cef was curvilinear at 0.01-0.5 mmol.L-1. The values of apparent Kt, Jmax, and Kd were 0.114 mmol, 78.41 nmol.h-1/(g wet tissue), and 43.70 nmol.h-1.mmol-1/(g wet tissue), respectively. Sodium edetate markedly promoted the disappearance rate of Cef from the intestine. CONCLUSION: Cef was transported partly via carrier-mediated transport system and partly via the paracellular transport system.  (+info)

Sequential antimicrobial therapy: treatment of severe lower respiratory tract infections in children. (3/116)

Although there have been a number of studies in adults, to date there has been little research into sequential antimicrobial therapy (SAT) in paediatric populations. The present study evaluates the impact of a SAT protocol for the treatment of severe lower respiratory tract infection in paediatric patients. The study involved 89 paediatric patients (44 control and 45 SAT). The SAT patients had a shorter length of hospital stay (4.0 versus 8.3 days), shorter duration of inpatient antimicrobial therapy (4.0 versus 7.9 days) with the period of iv therapy being reduced from a mean of 5.6 to 1.7 days. The total healthcare costs were reduced by 52%. The resolution of severe lower respiratory tract infection with a short course of iv antimicrobials, followed by conversion to oral therapy yielded clinical outcomes comparable to those achieved using longer term iv therapy. SAT proved to be an important cost-minimizing tool for realizing substantial healthcare costs savings.  (+info)

Susceptibilities of Yersinia pestis strains to 12 antimicrobial agents. (4/116)

Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are inhibited) against Y. pestis were cefixime, ceftriaxone, trimethoprim-sulfamethoxazole, and trovafloxacin.  (+info)

Modification of sorbitol MacConkey medium containing cefixime and tellurite for isolation of Escherichia coli O157:H7 from radish sprouts. (5/116)

A modified version of sorbitol MacConkey medium containing cefixime and tellurite (CT-SMAC medium) was produced by adding salicin and 4-methylumbelliferyl-beta-D-galactopyranoside to CT-SMAC medium; this medium was designated CT-SSMAC medium and was used to isolate Escherichia coli O157:H7 from radish sprouts. Of 101 non-E. coli bacteria isolated from radish sprouts that produced colorless colonies similar to colonies of E. coli O157:H7 grown on CT-SMAC medium, 92 (91%) formed colonies that were red to pink or were beta-galactosidase negative and colorless on CT-SSMAC medium. On the other hand, colonies of E. coli O157:H7 strains were colorless and beta-galactosidase positive on CT-SSMAC medium. Our results suggest that CT-SSMAC medium is more selective than CT-SMAC medium for isolating E. coli O157:H7.  (+info)

Cost-effectiveness of management strategies for acute urethritis in the developing world. (6/116)

OBJECTIVE: To recommend a cost-effective approach for the management of acute male urethritis in the developing world, based on the findings of a theoretical study. METHODS: A model was developed to assess the cost-effectiveness of three urethritis management strategies in a theoretical cohort of 1000 men with urethral syndrome. (1) All patients were treated with cefixime and doxycycline for gonococcal urethritis (GU) and nongonococcal urethritis (NGU), respectively, as recommended by WHO. (2) All patients were treated with doxycycline for NGU; treatment with cefixime was based on the result of direct microscopy of a urethral smear. (3) All patients were treated with cotrimoxazole or kanamycin for GU and doxycycline for NGU. Cefixime was kept for patients not responding to the first GU treatment. Strategy costs included consultations, laboratory diagnosis (where applicable) and drugs. The outcome was the rate of patients cured of urethritis. Cost-effectiveness was measured in terms of cost per cured urethritis. RESULTS: Strategy costs in our model depended largely on drug costs. The first strategy was confirmed as the most effective but also the most expensive approach. Cefixime should cost no more than US$ 1.5 for the strategy to be the most cost-effective. The second strategy saved money and drugs but proved a valuable alternative only when laboratory performance was optimal. The third strategy with cotrimoxazole was the least expensive but a low follow-up visit rate, poor treatment compliance or lower drug efficacy limited effectiveness. Maximizing compliance by replacing cotrimoxazole with single-dose kanamycin had the single greatest impact on the effectiveness of the third strategy. CONCLUSION: Our model suggested that a cost-effective approach would be to treat gonorrhoea with a single-dose antibiotic selected from locally available products that cost no more than US$ 1.5.  (+info)

Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer. (7/116)

Empiric oral antibiotic therapy for febrile neutropenic cancer patients has been suggested as a means to decrease hospitalization, but the safety of this approach has not been adequately studied in children. We compared continued iv antibiotic therapy with switching treatment to orally administered cefixime in a group of selected febrile neutropenic children for whom blood cultures were sterile after 48 h of incubation. Two hundred episodes of febrile neutropenia were studied (156 patients), and 100 episodes were randomized to receive each treatment. Failure to respond to therapy was defined by documented or suspected bacterial infection, recurrent fever, or discontinuation of assigned therapy for any reason before neutropenia resolved. Rates of treatment failure were similar in the oral cefixime group (28%) and in the iv antibiotic group (27%; P=1.0). Results support the safety of oral cefixime therapy for low-risk febrile neutropenic children, a therapeutic approach that would facilitate earlier outpatient management and decrease the costs of treatment.  (+info)

A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines. (8/116)

From 1994 through 1996-1997, high-level ciprofloxacin resistance (minimum inhibitory concentration [MIC], > or = 4.0 microg/mL) increased from 9% to 49% of gonococcal isolates recovered from consecutive female sex workers in Cebu and Manila, The Philippines (P < .01). During 1996-1997, 105 female sex workers with gonorrhea were prospectively randomized to receive treatment with oral ciprofloxacin, 500 mg, or cefixime, 400 mg, and followed for test of cure. Neisseria gonorrhoeae was reisolated within 28 days after treatment from 1 (3.8%) of 26 women given cefixime versus 24 (32.3%) of 72 women given ciprofloxacin (P < .01). Treatment failure (reisolation of pretreatment auxotype/serovar) occurred in 14 (46.7%) of 30 women infected with strains with MICs of ciprofloxacin > or = 4.0 microg/mL versus 1 (3.6%) of 28 infected by strains with MICs < 4.0 microg/mL (P < .01). High-level, clinically significant gonococcal resistance to ciprofloxacin has rapidly emerged in The Philippines, and spread of fluoroquinolone resistance through commercial sex poses a threat to control of gonorrhea and prevention of human immunodeficiency virus infection and the acquired immunodeficiency syndrome.  (+info)

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Product Name: Cefixime and Ofloxacin Tablets. Common Name: Suprax,Setic, Cefolac,cefspan. Strength: 200 mg+ 200 mg. Description:. Cefixime is an antibioticuseful for the treatment of a number of bacterial infections. It is a third generation cephalosporin.. Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.. Indications and Usage:. Cefixime Trihydrate is an oral third generation cephalosporin antibiotic used to treat infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, lung, throat, and urinary tract infections.Cefixime is used to treat many different types of infections caused by bacteria. Cefixime may also be used for other purposes not listed in this medication guide. It is used for the treatment of Typhoid Fever, Urinary Tract Infection, Respiratory Tract Infection, Nosocomial Infections, Soft Tissue Infections, Surgical Prophylaxis, Intra-abdominal ...
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TY - JOUR. T1 - Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy. AU - Carannante, Anna. AU - Vacca, Paola. AU - Ghisetti, Valeria. AU - Latino, Maria Agnese. AU - Cusini, Marco. AU - Matteelli, Alberto. AU - Vocale, Caterina. AU - Prignano, Grazia. AU - Leli, Christian. AU - Ober, Patrizia. AU - Antonetti, Raffaele. AU - Poletti, Federica. AU - Stefanelli, Paola. PY - 2017/3. Y1 - 2017/3. N2 - A strictly defined subset of gonococci (n = 65) isolated in Italy from 2011 to 2014 was characterized by antimicrobial susceptibility for cefixime (CFM) and ceftriaxone (CRO) and by sequencing of resistance determinant genes (penA, mtrR, porB1b, ponA) for extended-spectrum cephalosporins and Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST). The penA mosaic alleles XXXIV and XXXV were found in all resistant (R) and decreased susceptibility (DS) gonococci to CFM, except for one. They were associated with an adenine deletion in the mtrR promoter ...
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[Clinical evaluation of cefixime (CFIX) in the treatment of urinary tract infection].: Cefixime (CFIX, Cefspan), a new oral cephem, was used in the treatment of
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A comparison of single-dose cefixime with ceftriaxone as treatment for uncomplicated gonorrhea. Enoxacin in the therapy of anal and pharyngeal gonococcal infections
FIG. 3. Effects of deletion of the MtrC-MtrD-MtrE efflux pump or reversion of penB to the wild-type sequence in strains FA6140, FA6140 penA35, and 35/02 on the MICs of penicillin G, ceftriaxone, and cefixime. To investigate the individual contributions of mtrR and penB to Cephi, FA6140, FA6140 penA35, and 35/02 were transformed with plasmids harboring mtrD insertionally inactivated with a kanamycin resistance cassette or porB1b with a downstream erythromycin resistance cassette, and the MICs of the resulting transformants were determined as described in Materials and Methods. The MICs represent the averages ± standard deviations for at least two transformants in a minimum of three independent experiments. ...
GPs and internet pharmacies that provide access to online prescribing services should review their gonorrhoea treatment protocols to ensure they comply with national recommendations, say chief medical officer Dame Sally Davies and chief pharmaceutical officer Keith Ridge.
Cefpodoxime proxetil 200 mg is less active against n. Gonorrhoeae in vitro than cefixime and also does not quite meet the minimum efficacy criteria with cure rates, 96. 9) for urogenital.
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For Neisseria gonorrhoeae (N. gonorrhoeae) infections, the rate of clinical treatment failure with cefixime is 6.77%, and is associated with minimum inhibitory concentrations (MICs) of ≥0.12µg/mL.
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Generic Cefixime is in a group of drugs called cephalosporin antibiotics. It works by fighting bacteria in your body. This antibiotic is used to treat infection in the ear, nose, throat, sinuses, c...
What is this medicine? CEFIXIME (sef IX eem) is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections.
CAS No.: 79350-37-1 Product Name: Cefixime MF: C16H21N5O10S2 Place of Origin: Jiangxi, China Type: Antibiotic and Antimicrobial Agents, Endocrine System Agents Grade Standard: Medicine Grade, Tech Grade Brand Na...
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Cefixime is a suitable oral alternative. Typhoid fever, when properly treated, is not fatal in most cases. Antibiotics, such as ... Cao XT, Kneen R, Nguyen TA, Truong DL, White NJ, Parry CM (March 1999). "A comparative study of ofloxacin and cefixime for ... Bhutta ZA, Khan IA, Molla AM (November 1994). "Therapy of multidrug-resistant typhoid fever with oral cefixime vs. intravenous ...
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Ceftriaxone and cefixime are third generation cephalosporins and are often used as treatments for N. gonorrhoeae infections. ... These include: cefixime (an oral cephalosporin), ceftriaxone (an injectable cephalosporin), azithromycin, aminoglycosides, and ... Unemo, Golparian, Nicholas, Ohnishi, Gallay, Sednaoui (2011) High-Level Cefixime- and Ceftriaxone-Resistant Neisseria ...
Cefixime: an oral option for the treatment of multidrug-resistant enteric fever in children. Retrieved, US National Library of ... Cefixime: an oral option for the treatment of multidrug-resistant enteric fever in children. Detection and management of ...
The treatment of choice is often azithromycin and cefixime to cover both gonorrhoeae and chlamydia. Fluoroquinolones are no ...
Cefixime 400 mg oral single dose can be used as an alternative if ceftriaxone is not available. Non-gonococcal urethritis ( ...
This is for example done with Cefixime and Cefdinir by putting a vinyl group in the C-3 position. The fourth generation ...
The sample is cultured on sorbitol-MacConkey (SMAC) agar, or the variant cefixime potassium tellurite sorbitol-MacConkey agar ( ...
... doxycycline was considered a first-line treatment for chlamydia and non-gonococcal urethritis and with cefixime for ...
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Canada Cefixime, by the trade name CFIX This disambiguation page lists articles associated with the title CFIX. If an internal ...
Resistance to cefixime has reached a level such that it is no longer recommended as a first-line agent in the United States, ...
Children with acute pyelonephritis can be treated effectively with oral antibiotics (cefixime, ceftibuten and amoxicillin/ ...
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... may refer to: Encef, a trade name in India for cefixime Encef, a trade name in India for ceftriaxone Encef, a trade name ...
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"Suprax- cefixime tablet Suprax- cefixime capsule Suprax- cefixime tablet, chewable Suprax- cefixime powder, for suspension". ... There is no specific antidote for Cefixime overdosage. Gastric lavage may be performed. Dialysis will not remove Cefixime in ... Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime ... Cefixime was patented in 1979 and approved for medical use in the United States in 1989. It is on the World Health ...
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The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...
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"Suprax- cefixime tablet Suprax- cefixime capsule Suprax- cefixime tablet, chewable Suprax- cefixime powder, for suspension". ... There is no specific antidote for Cefixime overdosage. Gastric lavage may be performed. Dialysis will not remove Cefixime in ... Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime ... Cefixime was patented in 1979 and approved for medical use in the United States in 1989. It is on the World Health ...
Cefixime: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take cefixime even if you feel better. If you stop taking cefixime too soon or skip doses, your infection may not ... Before taking cefixime,. *tell your doctor and pharmacist if you are allergic to cefixime; other cephalosporin antibiotic such ... Cefixime tablets come with a line down the middle of the tablet. If your doctor tells you to take half a tablet, break it ...
Cefixime is a type of antibiotic called a cephalosporin. These antibiotics are related to penicillin. Cefixime is used to treat ... Suprax tablets and paediatric oral suspension contain the active ingredient cefixime, which is a type of medicine called an ... Cefixime is used to treat infections wih bacteria.. Cefixime works by interfering with the ability of bacteria to form cell ... Suprax (cefixime). Suprax tablets and paediatric oral suspension contain the active ingredient cefixime, which is a type of ...
... and gonorrhea.Read more about the prescription drug cefixime (Suprax). ... Information on the drug cefixime (Suprax) prescribed for the treatment of bacterial infections such as sore throats, ear ... What is cefixime, and how does it work (mechanism of action)?. Cefixime is a semi-synthetic (partially man-made), oral ... Is cefixime safe to take if Im pregnant or breastfeeding?. Safety in pregnancy has not been established for cefixime. There ...
Wyeths patent for cefixime expired on November 10, 2002. No other pharmaceutical company manufactures or sells cefixime ... Cefixime is the only CDC-recommended oral antimicrobial agent to which Neisseria gonorrhoeae has not developed significant ... Wyeth will continue to sell cefixime suspension (100 mg/5 ml) until March 31, 2003, or until company inventory is depleted, ... Also, in the absence of cefixime, ceftriaxone is the only CDC-recommended gonorrhea treatment option for young children and ...
CEFIXIME (sef IX eem) is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections. ... Cefixime oral suspension. What is this medicine?. CEFIXIME (sef IX eem) is a cephalosporin antibiotic. It is used to treat ... an unusual or allergic reaction to cefixime, other cephalosporin or penicillin antibiotics, other foods, dyes or preservatives ...
Suprax (cefixime) and ofloxacin are antibiotics used to treat bronchitis, pneumonia, urinary tract infections (UTIs), and ... home/medications health center/medications a-z list/suprax cefixime vs ofloxacin article ...
cefixime - Prescribed for Urinary Tract Infection, Bladder Infection, Bronchitis, Gonococcal Infection - Disseminated, ... I have friend, a physician I tell him and he gave me Cefixime 200mg tab. I have 2, he instructed me to take 400mg in a single ... See the full cefixime side effects document.. Commonly reported side effects include: pyelonephritis, arthralgia, and ...
Detailed Cefixime dosage information for adults and children. Includes dosages for Urinary Tract Infection, Bronchitis, Otitis ... Cefixime is generally effective in the eradication of S pyogenes from the nasopharynx; however, its efficacy in the subsequent ... Cefixime is generally effective in the eradication of S pyogenes from the nasopharynx; however, its efficacy in the subsequent ...
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Cefixime) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... Cefixime(a). 4 mg/kg BID. Cefixime(a). 8 mg/kg QD. Control(a). drugs. ... cefixime) Tablets, Capsules, Chewable Tablets, and Oral suspension. DESCRIPTION. Cefixime is a semisynthetic, cephalosporin ... Suprax (cefixime) is contraindicated in patients with known allergy to cefixime or other cephalosporins. ...
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  • Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. (wikipedia.org)
  • Suprax tablets and paediatric oral suspension contain the active ingredient cefixime, which is a type of medicine called an antibiotic. (netdoctor.co.uk)
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  • Cefixime is a broad-spectrum antibiotic that kills a wide variety of bacteria that cause a wide variety of commonly-occuring infections. (netdoctor.co.uk)
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  • The availability of cefixime 400 mg tablets increases options to treat gonorrhea, one of the most common sexually transmitted diseases in the U.S. Since April 2007, CDC has advised providers not to use fluoroquinolones (ciprofloxacin, ofloxacin, and levofloxacin) for the treatment of gonorrhea, based on data indicating widespread drug resistance in the U.S. (www.cdc.gov/mmwr/preview/mmwrhtml/mm5614a3.htm). (cdc.gov)
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  • However, treatment failure with this cefixime regimen was observed in our 4 cases of gonorrhea. (cdc.gov)
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  • Recently, the first Neisseria gonorrhoeae strain (H041) highly resistant to the expanded-spectrum cephalosporins (ESCs) ceftriaxone and cefixime, which are the last remaining options for first-line gonorrhea treatment, was isolated in Japan. (nih.gov)
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  • Cefixime is in a class of medications called cephalosporin antibiotics. (medlineplus.gov)
  • Antibiotics such as cefixime will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • If you stop taking cefixime too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Cephalosporins are slightly older but this group of antibiotics has many generations and cefixime belongs to the newer generation so it too is effective against a wide range of bacteria. (wisegeek.com)
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  • Since Cefixime Oral Suspension is one of beta-lactam antibiotics, the side effects of this group are very similar. (rxmedscanada.com)
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  • Cefixime comes as a tablet, chewable tablet, capsule, and suspension (liquid) to take by mouth. (medlineplus.gov)
  • Lupin Pharmaceuticals, Inc., received Food and Drug Administration (FDA) approval to manufacture and market cefixime in 2004, but has only had an oral suspension form available. (cdc.gov)
  • Wyeth will continue to sell cefixime suspension (100 mg/5 ml) until March 31, 2003, or until company inventory is depleted, whichever is sooner. (cdc.gov)
  • Inactive ingredients contained in SUPRAX ® (cefixime) powder for oral suspension USP are: colloidal silicon dioxide, sodium benzoate, strawberry flavor, sucralose (only in 500 mg/5 mL strength), sucrose, and xanthan gum. (rxlist.com)
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  • In vivo study was carried out using Pluronic sd in male Wister rats (n=6) and which showed enhanced absorption of Cefixime with AUC 1.9 times greater than of the aqueous plain Cefixime suspension. (omicsonline.org)
  • And this fact explains the popularity of Cefixime Oral Suspension among patients, especially children. (rxmedscanada.com)
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  • Like other cephalosporins, cefixime stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. (medicinenet.com)
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  • While both cefixime and ofloxacin effectively eradicate similar strains of bacteria, ofloxacin's different chemical structure and method of killing bacteria make many microbes less resistant to it. (wisegeek.com)
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  • Although cefixime is an effective alternative to other anti-infective agents for the treatment of many infections, the drug offers no clear advantage except for a convenient dosage regimen over other equally effective, less expensive anti-infectives available for the treatment of uncomplicated urinary tract infections or upper and lower respiratory tract infections. (clicksor.com)
  • HealthDay News) - For Neisseria gonorrhoeae ( N. gonorrhoeae ) infections, the rate of clinical treatment failure with cefixime is 6.77%, and is associated with minimum inhibitory concentrations (MICs) of ≥0.12µg/mL, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association . (empr.com)
  • In summary, we identified a relatively high rate of clinical failure in a clinic in Toronto after treatment of N gonorrhoeae infections with cefixime, which was associated with elevated MICs," the authors write. (empr.com)
  • The observed drop in cefixime and ceftriaxone resistance in Europe is encouraging," says Andrew Amato, Head of ECDC's programme on HIV/AIDS, sexually transmitted infections and viral hepatitis. (physiciansweekly.com)
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  • In other situations, your healthcare provider may decide to try cefixime without such tests, especially for infections that are not severe. (emedtv.com)
  • Cefixime doesn't work for viral infections like flu. (lybrate.com)
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  • Cefixime is used in the treatment of bone and joint infections like septic arthritis and osteomyelitis caused by Staphylococci and Streptococci species. (lybrate.com)
  • You should begin to feel better during the first few days of treatment with cefixime. (medlineplus.gov)
  • This case represents the first report of both CNS relapse during therapy with TMP-SMX and successful treatment with cefixime. (nih.gov)
  • Nursing Mothers: Consideration should be given to discontinuing nursing temporarily during treatment with cefixime. (nih.gov)
  • We report an N. gonorrhoeae isolate in Argentina that was resistant to ceftriaxone and cefixime. (cdc.gov)
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  • The penA35 allele from the Ceph i strain 35/02 was transformed into FA19 or FA6140, and the MICs of penicillin G, ceftriaxone, and cefixime for the resulting strains were determined as described in Materials and Methods. (asm.org)
  • MICs of penicillin G, ceftriaxone, and cefixime for stepwise transformants of penA35 , mtrR , penB35 , and ponA1 in strain FA19. (asm.org)
  • The MICs of penicillin G, ceftriaxone, and cefixime for the resulting strains were determined as described in Materials and Methods and represent the averages ± standard deviations for at least two transformants in a minimum of three independent experiments. (asm.org)
  • Effects of deletion of the MtrC-MtrD-MtrE efflux pump or reversion of penB to the wild-type sequence in strains FA6140, FA6140 penA35 , and 35/02 on the MICs of penicillin G, ceftriaxone, and cefixime. (asm.org)
  • Effects of reverting the ponA1 sequence to the wild-type ponA sequence in strains FA6140 penA35 and 35/02 on the MICs of penicillin G, ceftriaxone, and cefixime. (asm.org)
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  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that cefixime chewable tablets are sweetened with aspartame that forms phenylalanine. (medlineplus.gov)
  • The renewed availability of cefixime in oral form is a positive step in controlling the spread of this serious disease that affects roughly 700,000 Americans each year. (cdc.gov)
  • Cefixime is the only CDC-recommended oral antimicrobial agent to which Neisseria gonorrhoeae has not developed significant resistance ( 1 ). (cdc.gov)
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  • The plasma time course in the bile duct-cannulated rat exhibited a biexponential curve after the rapid iv administration of cefixime. (semanticscholar.org)
  • The isolates showed cefixime MICs of 0.5-1 μg/mL and harbored mosaic alterations in PBP 2. (cdc.gov)
  • The MIC(90) of cefixime for the 61 isolates tested was 0.125 microg/ml. (nih.gov)
  • In 2014, 23 EU/EEA countries collected and tested more than 2,000 gonococcal isolates and found a significantly lower proportion with cefixime resistance (2%), compared with 2013 when 4.7% of the tested isolates were not susceptible to this drug. (physiciansweekly.com)
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  • See the full cefixime side effects document. (drugs.com)
  • Gastrointestinal side effects are common with both cefixime and ofloxacin. (wisegeek.com)
  • Anticoagulants such as warfarin increase their side effects with the use of Cefixime. (drugstoretm.com)
  • Cefixime might have some side effects but it's not possible to anticipate them. (internationaldrugmart.com)
  • How can the drug interactions and side effects of Cefixime be minimized or completely avoided? (internationaldrugmart.com)
  • This is not a complete list of cefixime side effects. (rxwiki.com)
  • Serious side effects have been reported with cefixime. (rxwiki.com)
  • Cefixime was well tolerated, and all side effects were mild and self-limited. (asm.org)
  • Another survey conducted in the UK found that when cefixime tablets ip 200 mg uses and side effects people run out of contact lens solution, they're using all sorts of disgusting junk, like limeade and butter. (dreamscapelighting.com)
  • silagra tablets side effects cefixime and ofloxacin tablets uses . (ejolts.net)
  • Cefixime can cause certain side effects too. (lybrate.com)