A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Semisynthetic broad-spectrum cephalosporin.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Substances that reduce the growth or reproduction of BACTERIA.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.

Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin. (1/116)

AIMS: The aim of this study was to determine the potential influence of variables such as the cell content in the fluid, and serum levels, on the concentrations of ceftibuten, cefixime and azithromycin in the middle ear fluid of patients suffering from acute otitis media. METHODS: This randomized, open study compared the penetration of ceftibuten (9 mg kg(-1) 18 patients), cefixime (8 mg kg(-1), 16 patients) and azithromycin (10 mg kg(-1) 16 patients) into the intracellular and extracellular compartments of middle ear fluid of 50 paediatric patients (aged 8-14 years) with acute otitis media. Middle ear fluid was extracted by tympanocentesis 4, 12 and 24 h after dosing and divided into two fractions: with cells (as collected) (C+) and cell-free (C-). Antibiotics were assayed in C+ and C- samples by h.p.l.c. RESULTS: Ceftibuten achieved greater penetration into middle ear fluid than cefixime and azithromycin. Higher concentrations of ceftibuten (CTB) and cefixime (CFX) were found in the C- fraction (CTB: 4h 13.3+/-1.86; 12h 4.7+/-1.18; 24h 0.5+/-0.2. CFX: 4h 3.2+/-1.4; 12h 1.5+/-0.5; 24h>(0.1 mgl(-1)) than in the C+ fraction (CTB:4 h 8.4+/-4.3; 12 h 2.88+/-1.19; 24 h 0.3+/-0.27. CFX: 4 h 1.2+/-0.6; 12 h 0.8+/-0.2; 24 h>0.1 mg l(-1)) at the each time point, while the opposite was true for azithromycin (C-: 4 h 0.11+/-0.04; 12 h 0.12+/-0.08; 24 h 0.23+/-0.12. C+: 4 h 0.38+/-0.24; 12 h 0.9+/-0.03; 24 h 1.05+/-0.3 mg l(-1)). CONCLUSIONS: This study demonstrates that the penetration of antibiotics into the middle ear fluid is influenced by its serum concentrations as well as by the cell content in the fluid. Ceftibuten achieved higher middle ear fluid concentrations than cefixime in C+ and C- fractions at all time points. Both ceftibuten and cefixime concentrations are negatively influenced by the cell content in the fluid. In contrast the concentration of azithromycin to the middle ear fluid is positively influenced by the cell content in the fluid.  (+info)

Intestinal absorption of cefixime in rats. (2/116)

AIM: To study the intestinal absorption characters of cefixime (Cef) and the factors affecting Cef absorption. METHODS: A rat intestine loop in situ technique was used to investigate the disappearance rate of Cef from the intestine. Cef concentration in the flux was measured by the reversed phase HPLC. RESULTS: Cef was mainly absorbed from the upper part of the intestine. Its disappearance rate was apparently pH-dependent [(5.8 +/- 0.6) nmol.h-1/(g wet tissue) at pH 7.4, (8.9 +/- 1.4) nmol.h-1/(g wet tissue) at pH 5.0, P < 0.05)]. The uptake rate of Cef was curvilinear at 0.01-0.5 mmol.L-1. The values of apparent Kt, Jmax, and Kd were 0.114 mmol, 78.41 nmol.h-1/(g wet tissue), and 43.70 nmol.h-1.mmol-1/(g wet tissue), respectively. Sodium edetate markedly promoted the disappearance rate of Cef from the intestine. CONCLUSION: Cef was transported partly via carrier-mediated transport system and partly via the paracellular transport system.  (+info)

Sequential antimicrobial therapy: treatment of severe lower respiratory tract infections in children. (3/116)

Although there have been a number of studies in adults, to date there has been little research into sequential antimicrobial therapy (SAT) in paediatric populations. The present study evaluates the impact of a SAT protocol for the treatment of severe lower respiratory tract infection in paediatric patients. The study involved 89 paediatric patients (44 control and 45 SAT). The SAT patients had a shorter length of hospital stay (4.0 versus 8.3 days), shorter duration of inpatient antimicrobial therapy (4.0 versus 7.9 days) with the period of iv therapy being reduced from a mean of 5.6 to 1.7 days. The total healthcare costs were reduced by 52%. The resolution of severe lower respiratory tract infection with a short course of iv antimicrobials, followed by conversion to oral therapy yielded clinical outcomes comparable to those achieved using longer term iv therapy. SAT proved to be an important cost-minimizing tool for realizing substantial healthcare costs savings.  (+info)

Susceptibilities of Yersinia pestis strains to 12 antimicrobial agents. (4/116)

Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are inhibited) against Y. pestis were cefixime, ceftriaxone, trimethoprim-sulfamethoxazole, and trovafloxacin.  (+info)

Modification of sorbitol MacConkey medium containing cefixime and tellurite for isolation of Escherichia coli O157:H7 from radish sprouts. (5/116)

A modified version of sorbitol MacConkey medium containing cefixime and tellurite (CT-SMAC medium) was produced by adding salicin and 4-methylumbelliferyl-beta-D-galactopyranoside to CT-SMAC medium; this medium was designated CT-SSMAC medium and was used to isolate Escherichia coli O157:H7 from radish sprouts. Of 101 non-E. coli bacteria isolated from radish sprouts that produced colorless colonies similar to colonies of E. coli O157:H7 grown on CT-SMAC medium, 92 (91%) formed colonies that were red to pink or were beta-galactosidase negative and colorless on CT-SSMAC medium. On the other hand, colonies of E. coli O157:H7 strains were colorless and beta-galactosidase positive on CT-SSMAC medium. Our results suggest that CT-SSMAC medium is more selective than CT-SMAC medium for isolating E. coli O157:H7.  (+info)

Cost-effectiveness of management strategies for acute urethritis in the developing world. (6/116)

OBJECTIVE: To recommend a cost-effective approach for the management of acute male urethritis in the developing world, based on the findings of a theoretical study. METHODS: A model was developed to assess the cost-effectiveness of three urethritis management strategies in a theoretical cohort of 1000 men with urethral syndrome. (1) All patients were treated with cefixime and doxycycline for gonococcal urethritis (GU) and nongonococcal urethritis (NGU), respectively, as recommended by WHO. (2) All patients were treated with doxycycline for NGU; treatment with cefixime was based on the result of direct microscopy of a urethral smear. (3) All patients were treated with cotrimoxazole or kanamycin for GU and doxycycline for NGU. Cefixime was kept for patients not responding to the first GU treatment. Strategy costs included consultations, laboratory diagnosis (where applicable) and drugs. The outcome was the rate of patients cured of urethritis. Cost-effectiveness was measured in terms of cost per cured urethritis. RESULTS: Strategy costs in our model depended largely on drug costs. The first strategy was confirmed as the most effective but also the most expensive approach. Cefixime should cost no more than US$ 1.5 for the strategy to be the most cost-effective. The second strategy saved money and drugs but proved a valuable alternative only when laboratory performance was optimal. The third strategy with cotrimoxazole was the least expensive but a low follow-up visit rate, poor treatment compliance or lower drug efficacy limited effectiveness. Maximizing compliance by replacing cotrimoxazole with single-dose kanamycin had the single greatest impact on the effectiveness of the third strategy. CONCLUSION: Our model suggested that a cost-effective approach would be to treat gonorrhoea with a single-dose antibiotic selected from locally available products that cost no more than US$ 1.5.  (+info)

Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer. (7/116)

Empiric oral antibiotic therapy for febrile neutropenic cancer patients has been suggested as a means to decrease hospitalization, but the safety of this approach has not been adequately studied in children. We compared continued iv antibiotic therapy with switching treatment to orally administered cefixime in a group of selected febrile neutropenic children for whom blood cultures were sterile after 48 h of incubation. Two hundred episodes of febrile neutropenia were studied (156 patients), and 100 episodes were randomized to receive each treatment. Failure to respond to therapy was defined by documented or suspected bacterial infection, recurrent fever, or discontinuation of assigned therapy for any reason before neutropenia resolved. Rates of treatment failure were similar in the oral cefixime group (28%) and in the iv antibiotic group (27%; P=1.0). Results support the safety of oral cefixime therapy for low-risk febrile neutropenic children, a therapeutic approach that would facilitate earlier outpatient management and decrease the costs of treatment.  (+info)

A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines. (8/116)

From 1994 through 1996-1997, high-level ciprofloxacin resistance (minimum inhibitory concentration [MIC], > or = 4.0 microg/mL) increased from 9% to 49% of gonococcal isolates recovered from consecutive female sex workers in Cebu and Manila, The Philippines (P < .01). During 1996-1997, 105 female sex workers with gonorrhea were prospectively randomized to receive treatment with oral ciprofloxacin, 500 mg, or cefixime, 400 mg, and followed for test of cure. Neisseria gonorrhoeae was reisolated within 28 days after treatment from 1 (3.8%) of 26 women given cefixime versus 24 (32.3%) of 72 women given ciprofloxacin (P < .01). Treatment failure (reisolation of pretreatment auxotype/serovar) occurred in 14 (46.7%) of 30 women infected with strains with MICs of ciprofloxacin > or = 4.0 microg/mL versus 1 (3.6%) of 28 infected by strains with MICs < 4.0 microg/mL (P < .01). High-level, clinically significant gonococcal resistance to ciprofloxacin has rapidly emerged in The Philippines, and spread of fluoroquinolone resistance through commercial sex poses a threat to control of gonorrhea and prevention of human immunodeficiency virus infection and the acquired immunodeficiency syndrome.  (+info)

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TY - JOUR. T1 - Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy. AU - Carannante, Anna. AU - Vacca, Paola. AU - Ghisetti, Valeria. AU - Latino, Maria Agnese. AU - Cusini, Marco. AU - Matteelli, Alberto. AU - Vocale, Caterina. AU - Prignano, Grazia. AU - Leli, Christian. AU - Ober, Patrizia. AU - Antonetti, Raffaele. AU - Poletti, Federica. AU - Stefanelli, Paola. PY - 2017/3. Y1 - 2017/3. N2 - A strictly defined subset of gonococci (n = 65) isolated in Italy from 2011 to 2014 was characterized by antimicrobial susceptibility for cefixime (CFM) and ceftriaxone (CRO) and by sequencing of resistance determinant genes (penA, mtrR, porB1b, ponA) for extended-spectrum cephalosporins and Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST). The penA mosaic alleles XXXIV and XXXV were found in all resistant (R) and decreased susceptibility (DS) gonococci to CFM, except for one. They were associated with an adenine deletion in the mtrR promoter ...
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A comparison of single-dose cefixime with ceftriaxone as treatment for uncomplicated gonorrhea. Enoxacin in the therapy of anal and pharyngeal gonococcal infections
FIG. 3. Effects of deletion of the MtrC-MtrD-MtrE efflux pump or reversion of penB to the wild-type sequence in strains FA6140, FA6140 penA35, and 35/02 on the MICs of penicillin G, ceftriaxone, and cefixime. To investigate the individual contributions of mtrR and penB to Cephi, FA6140, FA6140 penA35, and 35/02 were transformed with plasmids harboring mtrD insertionally inactivated with a kanamycin resistance cassette or porB1b with a downstream erythromycin resistance cassette, and the MICs of the resulting transformants were determined as described in Materials and Methods. The MICs represent the averages ± standard deviations for at least two transformants in a minimum of three independent experiments. ...
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For Neisseria gonorrhoeae (N. gonorrhoeae) infections, the rate of clinical treatment failure with cefixime is 6.77%, and is associated with minimum inhibitory concentrations (MICs) of ≥0.12µg/mL.
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Generic Cefixime is in a group of drugs called cephalosporin antibiotics. It works by fighting bacteria in your body. This antibiotic is used to treat infection in the ear, nose, throat, sinuses, c...
What is this medicine? CEFIXIME (sef IX eem) is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections.
CAS No.: 79350-37-1 Product Name: Cefixime MF: C16H21N5O10S2 Place of Origin: Jiangxi, China Type: Antibiotic and Antimicrobial Agents, Endocrine System Agents Grade Standard: Medicine Grade, Tech Grade Brand Na...
Cefixime is a suitable oral alternative. Properly treated, typhoid fever is not fatal in most cases. Antibiotics such as ... Cao XT, Kneen R, Nguyen TA, Truong DL, White NJ, Parry CM (March 1999). "A comparative study of ofloxacin and cefixime for ... Bhutta ZA, Khan IA, Molla AM (November 1994). "Therapy of multidrug-resistant typhoid fever with oral cefixime vs. intravenous ...
Ceftriaxone and cefixime are third generation cephalosporins and are often used as treatments for N. gonorrhoeae infections. ... These include: cefixime (an oral cephalosporin), ceftriaxone (an injectable cephalosporin), azithromycin, aminoglycosides, and ... Unemo, Golparian, Nicholas, Ohnishi, Gallay, Sednaoui (2011) High-Level Cefixime- and Ceftriaxone-Resistant Neisseria ...
Cefixime: an oral option for the treatment of multidrug-resistant enteric fever in children. Retrieved, US National Library of ... Cefixime: an oral option for the treatment of multidrug-resistant enteric fever in children. Detection and management of ...
The treatment of choice is often azithromycin and cefixime to cover both gonorrhoeae and chlamydia. Fluoroquinolones are no ...
Cefixime 400 mg oral single dose can be used as an alternative if ceftriaxone is not available. Non-gonococcal urethritis ( ...
This is for example done with Cefixime and Cefdinir by putting a vinyl group in the C-3 position. The fourth generation ...
The sample is cultured on sorbitol-MacConkey (SMAC) agar, or the variant cefixime potassium tellurite sorbitol-MacConkey agar ( ...
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Trimethoprim Azithromycin Cefixime Cefotaxime Ceftriaxone Cefuroxime Ciprofloxacin Clarithromycin Piperacillin/tazobactam ( ...
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Azithromycin Cefixime Cefotaxime Ceftriaxone Cefuroxime Ciprofloxacin Clarithromycin Piperacillin/tazobactam (piperacillin + ...
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InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1 ...
On January 21, 2022, the Food and Drug Administration (FDA) reported a shortage of cefixime capsules. Cefixime is an oral ... If cefixime is not available, ceftriaxone, intramuscularly is the recommended treatment. Additional treatment guidance can be ... For more information regarding the availability of cefixime, visit the FDA Drug Shortage Websiteexternal icon. ...
Cefixime: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take cefixime even if you feel better. If you stop taking cefixime too soon or skip doses, your infection may not ... Before taking cefixime,. *tell your doctor and pharmacist if you are allergic to cefixime; other cephalosporin antibiotic such ... Cefixime tablets come with a line down the middle of the tablet. If your doctor tells you to take half a tablet, break it ...
The only CDC-recommended oral agent for treating uncomplicated urogenital or rectal gonorrhea is one dose of cefixime 400 mg, ... Lupin has been manufacturing and marketing cefixime oral suspension (100 mg/5 mL) since February 2004 and cefixime oral ... discontinued manufacturing cefixime tablets in the United States.[2] Beginning in April 2008, cefixime (Suprax®) 400 mg tablets ... Information on obtaining cefixime is available from Lupin by telephone (866-587-4617). Guidance on treatment of N. gonorrhoeae ...
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... treatment failure with this cefixime regimen was observed in our 4 cases of gonorrhea. The isolates showed cefixime MICs of 0.5 ... Although it is not clear whether these strains are also resistant to the single 400-mg dose of cefixime (8, 9), their emergence ... Threat to Cefixime Treatment for Gonorrhea. Emerging Infectious Diseases. 2007;13(8):1275. doi:10.3201/eid1308.060948.. ... Treatment comprised 200 mg cefixime, twice a day for 3 days. However, all 4 patients returned to the clinic with continuing ...
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  • If cefixime is not available, ceftriaxone, intramuscularly is the recommended treatment. (cdc.gov)
  • We report an N. gonorrhoeae isolate in Argentina that was resistant to ceftriaxone and cefixime. (cdc.gov)
  • We determined MICs of the isolate for penicillin, cefixime, ceftriaxone, tetracycline, ciprofloxacin, and azithromycin by using the agar dilution method according to the standard of the Clinical and Laboratory Standards Institute ( 4 ). (cdc.gov)
  • This isolate was resistant to ceftriaxone and cefixime (MIC 0.5 μg/mL), penicillin (8 μg/mL), tetracycline (8 μg/mL), and azithromycin (1 μg/mL). (cdc.gov)
  • Uncomplicated Gonococcal Infections Recommended Regimens - Ceftriaxone 125 mg IM in a single dose or Cefixime 400 mg orally in a single dose or Ciprofloxacin 500 mg orally in a single dose or Ofloxacin 400 mg orally in a single dose PLUS A regimen effective against possible coinfection with C. trachomatis, such as doxycycline 100 mg orally 2 times a day for 7 days. (cdc.gov)
  • Cefixime has an antimicrobial spectrum similar to that of ceftriaxone, but the 400 mg oral dose does not provide as high nor as sustained a bactericidal level as does 125 mg of ceftriaxone. (cdc.gov)
  • We looked at two currently recommended antibiotics, ceftriaxone and azithromycin, an antibiotic that's similar to ceftriaxone, called cefixime, and an antibiotic that was previously recommended for gonorrhea, called ciprofloxacin. (cdc.gov)
  • Cultures from both cases yielded N. gonorrhoeae resistant to ceftriaxone, cefixime, tetracycline, penicillin and ciprofloxacin and with intermediate resistance to azithromycin. (europa.eu)
  • Data on gonococcal susceptibility to azithromycin, ceftriaxone and cefixime were used from the Gonococcal Isolate Surveillance Project in 2015. (bmj.com)
  • Results A positive ecological association was found between STI screening intensity and geometric mean gonococcal minimum inhibitory concentration for ceftriaxone (rho=0.42, p=0.031) and cefixime (rho=0.42, p=0.029), but not for azithromycin (rho=0.31, p=0.11). (bmj.com)
  • None of the isolates was resistant to ceftriaxone or cefixime. (who.int)
  • Gonococcal Antimicrobial Surveil ance Programme has antimicrobials representing four different classes, namely operated in the Western Pacific and South-East Asian penicil in (PEN), ciprofloxacin (CIP), tetracycline (TCY), regions since 1992, but surveil ance of gonococcal anti- ceftriaxone (CRO) and cefixime (CFX), by disc diffusion microbial resistance (AMR) remains limited in the Asia- and gradient diffusion (Etest, BioMerieux). (who.int)
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  • Cefixime, sold under the brand name Suprax among others, is an antibiotic medication used to treat a number of bacterial infections. (wikipedia.org)
  • Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. (wikipedia.org)
  • Cefixime is an antibiotic that belongs to the family of medications known as cephalosporins . (medbroadcast.com)
  • Cefixime is a cephalosporin (SEF a low spor in) antibiotic . (us.org)
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