Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Cefamandole: Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.Cefotiam: One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.Cephalothin: A cephalosporin antibiotic.Cephaloridine: A cephalosporin antibiotic.ThiadiazolesPhenylmercury Compounds: Organic mercury compounds in which the mercury is attached to a phenyl group. Often used as fungicides and seed treatment agents.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Antibiotic Prophylaxis: Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Moxalactam: Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.Cephamycins: Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.Nafcillin: A semi-synthetic antibiotic related to penicillin.Cefmetazole: A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.Cefonicid: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.Staphylococcal Infections: Infections with bacteria of the genus STAPHYLOCOCCUS.Infusions, Parenteral: The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Surgical Wound Infection: Infection occurring at the site of a surgical incision.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Silver Compounds: Inorganic compounds that contain silver as an integral part of the molecule.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Nanospheres: Spherical particles of nanometer dimensions.Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Salmonella paratyphi B: A serotype of SALMONELLA ENTERICA which is an agent of PARATYPHOID FEVER in humans.Salmonella paratyphi A: A serotype of SALMONELLA ENTERICA that causes mild PARATYPHOID FEVER in humans.Paratyphoid Fever: A prolonged febrile illness commonly caused by several Paratyphi serotypes of SALMONELLA ENTERICA. It is similar to TYPHOID FEVER but less severe.Salmonella typhi: A serotype of SALMONELLA ENTERICA which is the etiologic agent of TYPHOID FEVER.Methicillin-Resistant Staphylococcus aureus: A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Methicillin Resistance: Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalEstersNG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.Meningitis, Listeria: Inflammation of the meninges caused by LISTERIA MONOCYTOGENES infection, usually occurring in individuals under the age of 3 years or over the age of 50 years. It may occur at any age in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. Clinical manifestations include FEVER, altered mentation, HEADACHE, meningeal signs, focal neurologic signs, and SEIZURES. (From Medicine 1998 Sep;77(5):313-36)Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)Listeria monocytogenes: A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion.Fractures, Closed: Fractures in which the break in bone is not accompanied by an external wound.Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.Fractures, Open: Fractures in which there is an external wound communicating with the break of the bone.Fracture Healing: The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Surgery, Veterinary: A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)Polymethyl Methacrylate: Polymerized methyl methacrylate monomers which are used as sheets, moulding, extrusion powders, surface coating resins, emulsion polymers, fibers, inks, and films (From International Labor Organization, 1983). This material is also used in tooth implants, bone cements, and hard corneal contact lenses.Fluorescence Polarization Immunoassay: Fluoroimmunoassay where detection of the hapten-antibody reaction is based on measurement of the increased polarization of fluorescence-labeled hapten when it is combined with antibody. The assay is very useful for the measurement of small haptenic antigens such as drugs at low concentrations.

Structure-function studies of Ser-289 in the class C beta-lactamase from Enterobacter cloacae P99. (1/308)

Site-directed mutagenesis of Ser-289 of the class C beta-lactamase from Enterobacter cloacae P99 was performed to investigate the role of this residue in beta-lactam hydrolysis. This amino acid lies near the active site of the enzyme, where it can interact with the C-3 substituent of cephalosporins. Kinetic analysis of six mutant beta-lactamases with five cephalosporins showed that Ser-289 can be substituted by amino acids with nonpolar or polar uncharged side chains without altering the catalytic efficiency of the enzyme. These data suggest that Ser-289 is not essential in the binding or hydrolytic mechanism of AmpC beta-lactamase. However, replacement by Lys or Arg decreased by two- to threefold the kcat of four of the five beta-lactams tested, particularly cefoperazone, cephaloridine, and cephalothin. Three-dimensional models of the mutant beta-lactamases revealed that the length and positive charge of the side chain of Lys and Arg could create an electrostatic linkage to the C-4 carboxylic acid group of the dihydrothiazine ring of the acyl intermediate which could slow the deacylation step or hinder release of the product.  (+info)

Pharmacokinetics of intermittent intraperitoneal cefazolin in continuous ambulatory peritoneal dialysis patients. (2/308)

OBJECTIVE: To investigate the pharmacokinetic parameters of intermittent intraperitoneal (IP) cefazolin, and recommend a cefazolin dosing regimen in continuous ambulatory peritoneal dialysis (CAPD) patients. DESIGN: Prospective nonrandomized open study. SETTING: CAPD outpatient clinic in Albany, New York. PATIENTS: Seven volunteer CAPD patients without peritonitis. Three of the patients were nonanuric while 4 were anuric. INTERVENTIONS: Cefazolin (15 mg/kg total body weight) was given to each patient during the first peritoneal exchange. Blood and dialysate samples were collected at times 0, 0.5, 1,2,3,6 (end of the first antibiotic-containing dwell), 24, and 48 hours after the administration of IP cefazolin. Urine samples were collected in nonanuric patients over the study period. RESULTS: The mean+/-SD amount of cefazolin dose absorbed from the dialysate after the 6-hour dwell was 69.7%+/-8.0% of the administered dose. The cefazolin absorption rate constant from dialysate to serum was 0.21+/-0.1/hr (absorption half-life 3.5+/-0.8 hr). The mean serum concentrations reached at 24 and 48 hours were 52.4+/-3.7 mg/L and 30.3+/-5.9 mg/L, respectively. The mean dialysate cefazolin concentrations reached at 24 and 48 hours were 15.1+/-3.4 mg/L and 7.9+/-1.4 mg/L, respectively. The cefazolin serum elimination rate constant was 0.02+/-0.01/hr (elimination half-life 31.5+/-8.8 hr). The total cefazolin body clearance was 3.4+/-0.6 ml/min. In the 3 nonanuric patients the mean renal clearance of cefazolin was 0.6+/-0.4 ml/min. The peritoneal clearance of cefazolin was 1.0+/-0.3 mL/min. The systemic volume of distribution of cefazolin was 0.2+/-0.05 L/kg. No statistical difference was detected in pharmacokinetic parameters between anuric and nonanuric patients, although this may be due to the small number of patients in each group. CONCLUSION: A single daily dose of cefazolin dosed at 15 mg/kg actual body weight in CAPD patients is effective in achieving serum concentration levels greater than the minimum inhibitory concentration for sensitive organisms over 48 hours, and dialysate concentration levels over 24 hours. Caution is warranted in extrapolation of dosing recommendations to patients who maintain a significant degree of residual renal function.  (+info)

Primary Shewanella alga septicemia in a patient on hemodialysis. (3/308)

We report the first Japanese case of primary septicemia with Shewanella alga and also describe the bacteriological characteristics of and results of antibiotic susceptibility tests of the isolate. S. alga was repeatedly isolated, at times simultaneously with Escherichia coli, from the blood of a 64-year-old female undergoing hemodialysis. The isolated organism was determined to be S. alga based on recently published identification criteria, such as hemolysis on sheep blood agar, no acid production from carbohydrates, and growth on agar containing 6. 5% NaCl. Results of antibiotic susceptibility tests demonstrated that the isolate was sensitive to levofloxacin and cefpirome (MICs, 128, 64, and 8 microg/ml, respectively). Although the role of S. alga as a human pathogen has not been fully determined, accumulating data suggest that this organism may be a potential pathogen, especially in compromised hosts.  (+info)

Prophylactic cefazolin in amnioinfusions administered for meconium-stained amniotic fluid. (4/308)

OBJECTIVE: To determine if amnioinfusion with an antibiotic solution decreased the rate of clinical chorioamnionitis and puerperal endometritis in patients with meconium-stained amniotic fluid. METHODS: Patients in labor at 36 weeks of gestation or greater with singleton pregnancies and meconium-stained amniotic fluid were randomized to receive either cefazolin, 1 g/1,000 mL, of normal saline (n = 90) or normal saline (n = 93) amnioinfusion. Rates of clinically diagnosed chorioamnionitis and endometritis and of suspected and culture-proven neonatal infection were determined. RESULTS: Between the study and control groups, the incidences of clinical chorioamnionitis (7.8% vs. 8.6%), endometritis (2.4% vs. 3.5%), aggregate intrauterine infection (10.0% vs. 11.8%), suspected neonatal infection (17.8% vs. 21.5%), and proven neonatal infection (0.0% vs. 2.2%) were not significantly different. CONCLUSIONS: Prophylactic use of cefazolin in amnioinfusions did not significantly reduce rates of maternal or neonatal infection in patients with meconium-stained amniotic fluid.  (+info)

Antibacterial activity of combinations of cefazolin and semisynthetic penicillins. (5/308)

The antibacterial activity of cephalosporin (CS) and semisynthetic penicillins was studied using CS-resistant strains of Escherichia freundii and Proteus morganii. A synergistic growth inhibitory action toward these microorganisms was demonstrated by a qualitative method and confirmed by a quantitative determination.  (+info)

Treatment of hospitalized patients with complicated gram-positive skin and skin structure infections: two randomized, multicentre studies of quinupristin/dalfopristin versus cefazolin, oxacillin or vancomycin. Synercid Skin and Skin Structure Infection Group. (6/308)

Quinupristin/dalfopristin (Synercid), the first injectable streptogramin antibiotic available for the treatment of complicated gram-positive skin and skin structure infections, was compared with standard comparators (cefazolin, oxacillin or vancomycin) in one USA and one international trial. These two randomized, open-label trials of virtually identical design enrolled a total of 893 patients (450 quinupristin/dalfopristin, 443 comparator). The majority of patients had erysipelas, traumatic wound infection or clean surgical wound infection. Staphylococcus aureus was the most frequently isolated pathogen in both treatment groups and polymicrobial infection was more common in the quinupristin/dalfopristin group than in the comparator group. The clinical success rate (cure plus improvement) in the clinically evaluable population was equivalent between the two treatment groups (68.2% quinupristin/dalfopristin, 70.7% comparator; 95% CI, -10.1, 5.1) despite a shorter mean duration of treatment for quinupristin/dalfopristin patients. In the bacteriologically evaluable population, by-patient and by-pathogen bacteriological eradication rates were somewhat lower for quinupristin/dalfopristin (65.8% and 66.6%, respectively) than for the comparator regimens (72.7% and 77.7%, respectively). The lower bacteriological response rates in the quinupristin/dalfopristin group were, in part, due to a higher rate of polymicrobial infections and a higher incidence of patients classified as clinical failure, a category which included premature discontinuation of treatment because of local venous adverse events. The bacteriological eradication rate for quinupristin/dalfopristin was higher in monomicrobial infections than in polymicrobial infections (72.6% versus 63.3%, respectively), whereas the corresponding rate for the comparator regimens was lower for monomicrobial infections than polymicrobial infections (70.8% versus 83.1%). This finding was not unexpected, since the spectrum of quinupristin/dalfopristin is focused on gram-positive pathogens and additional antibiotics to treat gram-negative bacteria were not required per protocol. The systemic tolerability of both treatment regimens was qualitatively similar. A higher rate of drug-related venous adverse events was reported for quinupristin/dalfopristin (66.2%) than for the comparator regimen (28.4%). Premature discontinuation of study drug was primarily due to adverse clinical events for quinupristin/dalfopristin (19.1%), whereas the most common reason for discontinuation among those receiving the comparator regimens was treatment failure (11.5%). Quinupristin/dalfopristin is an effective alternative for the treatment of hospitalized patients with complicated skin and skin structure infections due to quinupristin/ dalfopristin-susceptible gram-positive organisms, including methicillin- and erythromycin-resistant S. aureus.  (+info)

Bacteremic pneumonia caused by a single clone of Streptococcus pneumoniae with different optochin susceptibilities. (7/308)

Two isolates of Streptococcus pneumoniae having different optochin susceptibilities were recovered from a blood sample of a 2-year-old boy with community-acquired pneumonia. The two isolates were documented to belong to a single clone on the basis of the isolates' identical serotype (23F), antibiograms by the E-test, random amplified polymorphic DNA patterns generated by arbitrarily primed PCR, pulsed-field gel electrophoresis, and restriction fragment length polymorphism of the penicillin-binding protein genes pbp2b and pbp2x.  (+info)

Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers. (8/308)

AIM: To compare the clinical efficacy of commercially available fluoroquinolone drops with the use of combined fortified antibiotics (tobramycin 1.3%-cefazolin 5%) in treatment of bacterial corneal ulcer. METHODS: The medical records of 140 patients with a diagnosis of bacterial corneal ulcer who were admitted to the Royal Victorian Eye and Ear Hospital, Melbourne, Australia between January 1993 and December 1997 were reviewed retrospectively. Final outcome and results of 138 ulcer episodes were compared between those treated initially with fluoroquinolone and those who received fortified antibiotics. Two patients had been treated with chloramphenicol. RESULTS: No significant treatment difference was found between fluoroquinolone and fortified therapy in terms of final visual outcome. However, serious complications such as corneal perforation, evisceration, or enucleation of the affected eye were more common with fluoroquinolone therapy (16.7%) compared with the fortified therapy (2.4%, p= 0.02). The duration of intensive therapy was less with fluoroquinolone especially in those over 60 years of age (4 days v 6 days, p=0.01). Hospital stay was also less in the fluoroquinolone group compared with the fortified group for all patients and was significantly less with fluoroquinolone treatment (7 days v 10 days, p=0.02) in patients in the age group over 60 years old. CONCLUSIONS: Monotherapy with fluoroquinolone eye drops for the treatment of bacterial corneal ulcers led to shorter duration of intensive therapy and shorter hospital stay compared with combined fortified therapy (tobramycin-cefazolin). This finding may have resulted from quicker clinical response of healing as a result of less toxicity found in the patients treated with fluoroquinolone. However, as some serious complications were encountered more commonly in the fluoroquinolone group, caution should be exercised in using fluoroquinolones in large, deep ulcers in the elderly.  (+info)

*Cefazolin

... levels are not significantly affected by liver disease. As with other antibiotics, cefazolin may interact with other ... Caution should be used in breastfeeding as a small amount of cefazolin enters the breast milk. Cefazolin can be used ... Some important drugs that may interact with cefazolin such as probenecid. Side effects associated with use of cefazolin therapy ... Cefazolin is used in a variety of infections provided that susceptible organisms are involved. It is indicated for use in the ...

*SmithKline Corp. v. Eli Lilly & Co.

The first was SKC's Ancef (cefazolin); Lilly then introduced Kefzol, its identical form of cefazolin. Before 1973 Lilly adopted ... cefazolin). Lilly had patents on all its cephalosporin antibiotics except Kefzol (cefazolin), which this case concerns. From ...

*Serum sickness

"Serum sickness-like reaction associated with cefazolin". BMC Clin Pharmacol. 6: 3. doi:10.1186/1472-6904-6-3. PMC 1397863 . ...

*Enoxacin

De Sarro A, Zappalá M, Chimirri A, Grasso S, De Sarro GB (July 1993). "Quinolones potentiate cefazolin-induced seizures in DBA/ ...

*Amnioinfusion

Edwards RK, Duff P (1999). "Prophylactic cefazolin in amnioinfusions administered for meconium-stained amniotic fluid". Infect ...

*Probenecid

Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it ... Cox, VC; Zed, PJ (March 2004). "Once-daily cefazolin and probenecid for skin and soft tissue infections". The Annals of ...

*CSPC Zhongrun

The cephalosporin series includes intermediate 7-ACA, cefazolin sodium, cefazolin acid and ceftriaxone sodium. Meropenem API is ...

*Side effects of penicillin

Those medications that may cause a cross sensitivity reaction are: carbapenems, ampicillin, cefazolin, cephalosporins and ...

*Cefamandole

Cefazolin Ceforanide http://www.toku-e.com/Assets/MIC/Cefamandole%20sodium%20salt.pdf Stork CM (2006). "Antibiotics, ...

*Pseudomonas oryzihabitans

The types of antibiotics that P. oryzihabitans are resistant to ampicillin, amoxicillin-clavulanic acid, and cefazolin. Since ...

*Streptococcus agalactiae

Cefazolin, clindamycin, and vancomycin are used to prevent EOD in infants born to penicillin-allergic mothers. There are two ...

*Rothia dentocariosa

Rothia infections may be treated with penicillins, erythromycin, cefazolin, rifampin, aminoglycoside, tetracycline, ...

*Cefalotin

It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. ...

*Cefalexin

It works similarly to other agents within this class, including intravenous cefazolin, but can be taken by mouth. Cefalexin can ...

*Thielavia subthermophila

Fortified tobramycin, fortified cefazolin, fluorometholone, and scopolamine eyedrops can also be administered if necessary, ...

*Canine parvovirus

... and broad-spectrum antibiotic injections such as cefazolin/enrofloxacin, ampicillin/enrofloxacin, metronidazole, timentin, or ...

*Lysostaphin

Additionally, it has been shown that lysostaphin combined with antimicrobials such as cefazolin, clarithromycin, doxycycline, ...

*Lactobacillus fermentum

Out of ten common antibiotic genes that were tested (gatamicin, cefazolin, penicillin, trimethoprim/sulfmethoxazole, ampicillin ... cefazolin, penicillin, trimethoprim/sulfamethoxazole, ampicillin, carbenicillin, erythromycin, amikacin, and cholorampehnicol. ...

*Schedule H

Carbidopa Carbocisteine Carboplatin Injection Carboquone Carisoprodol L.Carnitine Cefadroxyl Cefatoxime Sodium Cefazolin Sodium ...

*ATCvet code QJ51

QJ51DB01 Cefalexin QJ51DB04 Cefazolin QJ51DB08 Cefapirin QJ51DB10 Cefacetrile QJ51DB90 Cefalonium QJ51DC02 Cefuroxime QJ51DD12 ...

*WHO Model List of Essential Medicines

Ampicillin Benzathine benzylpenicillin Benzylpenicillin Cefalexin Cefazolin Cefixime Cefotaxime Ceftriaxone Cloxacillin ...

*List of β-lactam antibiotics

Cefazolin Cephalexin Cephalosporin C Cephalothin Cefaclor Cefamandole Cefuroxime Cefotetan Cefoxitin Cefixime Cefotaxime ...

*List of MeSH codes (D02)

... cefazolin MeSH D02.065.589.099.249.177 --- cefonicid MeSH D02.065.589.099.249.185 --- cefsulodin MeSH D02.065.589.099.249.190 ...

*WHO Model List of Essential Medicines for Children

Ampicillin Benzathine benzylpenicillin Benzylpenicillin Cefalexin Cefazolin Ceftriaxone Cloxacillin Phenoxymethylpenicillin ( ...

*List of drugs: Cb-Ce

... cefazolin (INN) cefbuperazone (INN) cefcanel daloxate (INN) cefcanel (INN) cefcapene (INN) cefclidin (INN) cefdaloxime (INN) ...
Objective- To compare the in vitro elution characteristics of amikacin and cefazolin from polymethylmethacrylate (PMMA) alone and in combination.. Study Design- A prospective, controlled, experimental study.. Methods- Three aliquots of 6 g sterile PMMA were measured and to them added (1) 750 mg amikacin; (2) 1050 mg cefazolin; and (3) 750 mg amikacin and 1050 mg cefazolin. Ten beads of each antimicrobial/PMMA combination were placed in 5 mL phosphate-buffered saline (PBS) at pH 7.4 and room temperature with constant agitation. PBS was sampled at 15 time points between 1 hour and 30 days. Amikacin concentrations were determined by fluorescence polarization immunoassay and cefazolin concentrations by high-performance liquid chromatography.. Results- Amikacin and cefazolin eluted at concentrations greater than 8 and 4 times, respectively, above the minimum inhibitory concentration (MIC) for susceptible bacteria over 30 days. Co-elution of the antibiotics resulted in a greater rate and proportion of ...
OBJECTIVE To review the pharmacokinetics of 2g and 3g doses of cefazolin when used for peri-operative prophylaxis in obese gravidae undergoing cesarean delivery. in body mass index at time of cesarean delivery, there was an associated 13.77g/mL lower plasma concentration of cefazolin across all time points (p=0.01). By the completion of cesarean delivery, cefazolin concentrations in maternal adipose were consistently above the minimal inhibitory 870223-96-4 manufacture concentration for both gram-positive and gram-negative bacteria with both the 2g and 3g doses. The median umbilical cord blood concentrations were significantly higher in the 3g vs. the 2g group (34.5 g/mL and 21.4 g/mL: p=.003). CONCLUSION Cefazolin concentrations in maternal adipose both at time of hysterotomy closure and fascial closure were 870223-96-4 manufacture above the minimal inhibitory concentration for both gram-positive and gram-negative bacteria when either 2g or 3g cefazolin was administered 870223-96-4 manufacture ...
OBJECTIVE To review the pharmacokinetics of 2g and 3g doses of cefazolin when used for peri-operative prophylaxis in obese gravidae undergoing cesarean delivery. in body mass index at time of cesarean delivery, there was an associated 13.77g/mL lower plasma concentration of cefazolin across all time points (p=0.01). By the completion of cesarean delivery, cefazolin concentrations in maternal adipose were consistently above the minimal inhibitory 870223-96-4 manufacture concentration for both gram-positive and gram-negative bacteria with both the 2g and 3g doses. The median umbilical cord blood concentrations were significantly higher in the 3g vs. the 2g group (34.5 g/mL and 21.4 g/mL: p=.003). CONCLUSION Cefazolin concentrations in maternal adipose both at time of hysterotomy closure and fascial closure were 870223-96-4 manufacture above the minimal inhibitory concentration for both gram-positive and gram-negative bacteria when either 2g or 3g cefazolin was administered 870223-96-4 manufacture ...
We sought to assess the effects of cardiopulmonary bypass and profound hypothermic circulatory arrest on plasma cefazolin levels administered for antimicrobial prophylaxis in cardiovascular surgery.Four groups (10 patients per group) were prospectively studied: vascular surgery without cardiopulmonary bypass (group A), cardiac surgery with a cardiopulmonary bypass time of less than 120 minutes (group B), cardiac surgery with a cardiopulmonary bypass time of greater than 120 minutes (group C), and cardiac surgery with cardiopulmonary bypass and profound hypothermic circulatory arrest (group D). Subjects received cefazolin at induction and a second dose before wound closure. Arterial blood samples were obtained preceding cefazolin administration, at skin incision, hourly during the operation, and before redosing. Cefazolin plasma concentrations were determined by using a radial diffusion assay, with Staphylococcus aureus as the indicator microorganism. Cefazolin plasma concentrations were ...
Cefazolin is administered parentrally .It reaches high concentrations in plasma and bile.Cefazolin has a longer half life( 2 hrs )hence used in surgical prophylaxis.80 % is protein bound. 90 % is excreted in the urine.
Cefazolin belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent
Professional guide for CeFAZolin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
The antimicrobial efficacy of cefazolin was tested in human patients undergoing urological operations. Concentrations in serum and homogenized skeletal muscle were determined by means of the agar...
79239-19-3 - AODDZVXSRQMZGM-TZMCWYRMSA-N - Cefazolin delta-2-methyl ester - Similar structures search, synonyms, formulas, resource links, and other chemical information.
cefazolin delta-2-methyl ester: RN given refers to (6R-trans)-isomer; RN for cpd without isomeric designation not available 2/91; structure given in first source
Sicef information about active ingredients, pharmaceutical forms and doses by Benedetti, Sicef indications, usages and related health products lists
The implant was placed subcutaneously in an aseptic procedure under general isoflurane inhalant anesthesia (1%-3%) with sustained-release meloxicam and buprenorphine for analgesia, and prophylactic intravenous cefazolin antibiotic. Prior to insertion, the implant unit was gas sterilized in ethylene dioxide. The battery pack/transceiver unit was sutured to underlying musculature between the scapulas with size-0 nylon monofilament through a 6-cm skin incision; the leads and transducers were then routed subcutaneously to the right orbit for IOP, the cranium for ICP, and the left neck or left leg for arterial BP. For IOP transducer placement, a 6.25-mm-diameter hole was drilled in the lateral orbit with a hand drill, and a 1.5-cm fornix incision through the conjunctiva was made parallel to and 4 mm posterior to the limbus in the superotemporal quadrant. The dissection was then carried down through Tenons to the scleral surface. Blunt dissection of Tenons from sclera was carried anterior to the ...
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Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
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This study determined the pharmacokinetic characteristics of once daily intraperitoneal (IP) cefazolin in continuous ambulatory peritoneal dialysis (CAPD) patients. Each of the 10 volunteer CAPD patients without active peritonitis received a single IP dose of 1 g of cefazolin sodium for a 6-h dwell. All patients underwent a fixed CAPD regimen comprising a first 6-h dwell followed by two 3-h dwells and a final 12-h overnight dwell. Blood and dialysate samples were collected at 0, 0.5, 1, 2, 3, 6 (end of first dwell), and 24 h after the administration of IP cefazolin. Any urine produced was collected over the 24-h study period. A validated HPLC method was used to analyze cefazolin in plasma, dialysate, and urine. The bioavailability was found to be 77.9 ± 3.1%, volume of distribution 0.20 ± 0.05 L/kg, and plasma half-life 39.9 ± 25.4 h. Mean total, renal, and peritoneal clearances were 4.5 ± 2.3, 1.4 ± 1.1, and 3.5 ± 1.8 ml/min, respectively. Mean plasma and dialysate concentrations at 24 h ...
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TY - JOUR. T1 - Cefazolin for hysterectomy prophylaxis. AU - Hemsell, D. L.. AU - Johnson, E. R.. AU - Hemsell, P. G.. AU - Nobles, B. J.. AU - Heard, M. C.. PY - 1990. Y1 - 1990. N2 - Efficacy data for single-dose cefazolin prophylaxis at hysterectomy are meager, and there are none evaluating the impact of route of administration on efficacy. For these reasons, 772 women undergoing elective abdominal or vaginal hysterectomy for benign diseases were given 1 g cefazolin either intramuscularly or intravenously in a randomized clinical trial. Preoperative diagnoses and clinical, surgical, and outcome variables were similar by route of administration for each surgical approach. Risk factors for infection after abdominal hysterectomy included younger age, lower post-operative hemoglobin concentration, and pelvic hematoma; women who developed infection after vaginal hysterectomy were heavier than thsoe who remained uninfected and were more likely to have a pelvic hematoma. The overall incidence of ...
Background The incidence of surgical site infection in bariatric patients is significant and the current recommendations for antibiotic prophylaxis are sometimes inadequate. Objective The aim of this study was to analyze the effect of three prophylactic antibiotic regimens on the incidence of surgical site infection. Methods A prospective, cross-sectional study was conducted between January 2009 and January 2013 in which 896 Roux-en-Y gastric bypasses were performed to treat obesity. The study compared three groups of patients according to the perioperative antibiotic prophylaxis administered intravenously and beginning at anesthesia induction: Group I consisting of 194 patients treated with two 3-g doses of ampicillin/sulbactam; Group II with 303 patients treated with a single 1-g dose of ertapenem; and Group III with 399 patients treated with a 2-g dose of cefazolin at anesthesia induction followed by a continuous infusion of cefazolin 1g throughout the surgical procedure. The rate of surgical ...
The purpose of this study is to compare the incidence rate of infection in surgical patients with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the peri-operative period.. The hypothesis of this study is that patients undergoing surgical treatment for closed fractures who are treated prophylactically with Vancomycin will have a lower incidence rate of infection than patients who are treated prophylactically with Cefazolin. ...
Suboptimal response of meningitis to cephalothin therapy (1-2) and actual development of meningitis during cephalothin therapy (3) have been reported. We recently observed a patient who developed meningitis due to Listeria monocytogenes while he was being treated with the new cephalosporin antibiotic, cefazolin.. A 31-year-old Egyptian man with systemic lupus erythematosus and biopsy-proved lupus nephritis of the membranoproliferative type was admitted on 16 September 1974 with nephrotic syndrome and renal failure. He was treated with high dose prednisone, intermittent peritoneal dialysis, and after 10 days of hospitalization he was started on a course of nitrogen mustard. On 22 October 1974 ...
Surgical site infections are common and a cause of major morbidity. They are also more common in obese women. Cesarean sections are the most common surgery performed in the United States, therefore pregnant women are being faced with this problem frequently. There is evidence to show that prophylactically administered antibiotics, cefazolin specifically, to obese women prior to cesarean section do not reach adequate concentrations in adipose tissue to prevent infection. The purpose of this study is to evaluate if an increased dose of cefazolin will attain adequate tissue concentration in obese women. Our hypothesis is that three grams of cefazolin given no more than 60 minutes prior to the start of a cesarean section in an obese (Body mass index (BMI) greater than or equal to 30) woman will attain adequate adipose tissue concentration compared to two grams of cefazolin.. Subjects will be selected if they are greater than 37 weeks gestation wiht a singleton pregnancy and require a cesarean ...
1. Clean operation with or without use of prosthetic implant (hepatectomy, hydatid cyst liver without biliary communication, splenectomy, porto-systemic shunt operation). Recommendation: Inj Cefazolin 1 g i.v. or Cefuroxime 1.5 g i.v.. 2a. Clean contaminated operation (cholecystectomy laparoscopic and open, gastrojejunostomy, gastrectomy, jejunal resection anastomosis, distal pancreatectomy, pseudocyst gastrostomy, pseudocyst jejunostomy, low risk perforated peptic ulcer). Recommendation: Inj Cefazolin 1 g i.v. or Cefuroxime 1.5 g i.v. (evidence for prophylactic antibiotic in low risk laparoscopic cholecystectomy is thin). 2b. Clean contaminated operation (operation where upper aerodigestive tract is open, including oesophageal operations or gastric outlet obstruction). Recommendation: Inj Cefazolin 1 g i.v. + Inj Metronidazole 500 mg i.v.. 3. Contaminated operation (colectomy, obstructed biliary tract, choledocholithiasis) Recommendation: Inj Cefazolin 1 g i.v. or Cefuroxime 1.5 g i.v. + Inj ...
Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. Cefalexin is a beta-lactam antibiotic within the class of first-generation cephalosporins. It works similarly to other agents within this class, including intravenous cefazolin, but can be taken by mouth.. Cefalexin can treat certain bacterial infections, including those of the middle ear, bone and joint, skin, and urinary tract. It may also be used for certain types of pneumonia, strep throat, and to prevent bacterial endocarditis. Cefalexin is not effective against infections caused by methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus, or Pseudomonas. Like other antibiotics, cefalexin cannot treat viral infections, such as the flu, common cold or acute bronchitis. Cefalexin can be used in those who have mild or moderate allergies to penicillin. However, it is not ...
IgA-dominant post-infectious glomerulonephritis presenting as a fatal pulmonary-renal syndrome Marc Saad,1 Magda Daoud,1 Patricia Nasr,1 Rafeel Syed,2 Suzanne El-Sayegh,2 1Department of Medicine, 2Department of Nephrology, Staten Island University Hospital, Staten Island, NY, USA Abstract: Over the last decades, post-infectious glomerulonephritis underwent major changes in its epidemiology, pathophysiology, and outcomes. We are reporting a case of IgA-dominant post-infectious glomerulonephritis (IgA-PIGN) presenting as a fatal pulmonary-renal syndrome. An 86-year-old Filipino man presented with worsening dyspnea, hemoptysis, and decreased urine output over 2 weeks. Past medical history is significant for hypertension, chronic kidney disease stage III, and pneumonia 3 weeks prior treated with intravenous cefazolin for methicillin-sensitive Staphylococcus aureus bacteremia. Physical examination was remarkable for heart rate of 109/min and respiratory rate of 25/min saturating 99% on 3 liters via nasal
A recent AJKD article by Kitrungphaiboon et al explored whether cefepime monotherapy, as an empirical treatment of CAPD-associated peritonitis, has noninferior efficacy for the resolution of peritonitis at day 10 (primary treatment response) compared to the conventional combination regimen of cefazolin plus ceftazidime. AJKDs Social Media Editor, Timothy Yau @Maximal_Change, recorded an interview with his ID…
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Clinical Case for Discussion: You are attending to a healthy 72-year-old female for open reduction and internal fixation of a hip fracture. She is allergic to penicillin -- she developed hives from a dose when she was a child. The orthopedic surgeon orders 1 gram of cefazolin IV before incision. What do you do? Discussion: …
Compare prices and print coupons for Kefzol (Cefazolin) and other Skin Infection, Urinary Tract Infection, Bacterial Infection, Lower Respiratory Infection, and Upper Respiratory Infection drugs at CVS, Walgreens, and other pharmacies. Prices start at $94.67
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Každú stredu a piatok o 12:00 v GOLEM CLUB AUPARK. Prvá hodina 18.9.2013. BodyART je tréning, ktorý pristupuje k ľudskej bytosti ako spojeniu duše, mysle a tela. Ruka v ruke s myšlienkou filozofie „Jin-Jang" vhodne kombinuje funkčný tréning a klasické techniky dýchania, výdrží a strečingu za cieľom zaistiť správne fungovanie celého tela cez posilňovanie a stabilizáciu vnútorných svalov - svalov potrebných k bežnému ľudskému pohybu a celkovej existencii.. ...
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Cefazolin potency against methicillin-resistant Staphylococcus aureus: a microbiologic assessment in support of a novel drug delivery system for skin and skin structure infections David P Nicolau,1 Barry N Silberg2 1Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; 2Department of Surgery, Sonoma West Medical Center, Sebastopol, CT, USA Introduction: Despite aggressive medical and surgical management, the resolution of skin and skin structure infections is often difficult due to insufficient host response, reduced drug penetration, and a high prevalence of resistance organisms such as methicillin-resistant Staphylococcus aureus (MRSA). As a result of these factors, conventional management often consists of prolonged broad-spectrum systemic antimicrobials. An alternative therapy in development, ultrasonic drug dispersion (UDD), uses a subcutaneous injection followed by external transcutaneous ultrasound to deliver high tissue concentrations of cefazolin with limited
Cefazolin was used in the treatment of nine patients with acute enteric fever proven by positive blood cultures. In seven patients the causative organism was Salmonella typhi and in two it was Salmonella paratyphi B. Minimal inhibitory and minimal ba
TY - JOUR. T1 - An international survey of practice variation in the use of antibiotic prophylaxis in cesarean section. AU - Huskins, W. C.. AU - Ba-Thike, K.. AU - Festin, M. R.. AU - Limpongsanurak, S.. AU - Lumbiganon, P.. AU - Peedicayil, A.. AU - Purwar, M.. AU - Shenoy, S.. AU - Goldmann, D. A.. AU - Tolosa, Jorge. PY - 2001. Y1 - 2001. N2 - Objective: To examine the use of antibiotic prophylaxis in cesarean section in different countries and in relation to a reference regimen. Method: Fifty consecutive cesarean sections performed in eight centers in five countries were surveyed. Data from each center were compared to a regimen recommended by the Cochrane Collaboration (one dose of ampicillin or cefazolin administered to all women shortly before the procedure or immediately after cord clamping) using logistic regression with adjustment for procedure type. Result: Prophylaxis was used widely, but only four centers administered prophylaxis to all women. Ampicillin and cefazolin were the ...
Infectious morbidity for the mother, consisting primarily of endomyometritis and wound infection remains a leading cause of post operative complications. Infectious morbidity following CD remains among the top five causes of mortality in mothers worldwide, causing a huge burden to the society [9].. In the study by Sullivan et al. [7], on 357 women, decreased total infectious morbidity in the study group was found (RR = 0.4, 95% CI = 0.18 to 0.87). There was a decreased endometritis risk as well in the pre incision group (RR = 0.2, 95% CI = 0.15 to 0.94).There was no increase in neonatal sepsis (P = 0.99), sepsis work up (P = 0.96) or increased hospital stay (P = 0.17). In the present study, the results were almost similar in that, the incidence of SSI was decreased and duration of hospital stay was decreased with antibiotics given Pre-incision than after cord clamping. Unlike the study by Sullivan et al. [7], in the present study, the incidence of endometritis was similar in both groups. ...
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Clothing often ends up in the laundry with stickers still attached. Children use stickers to show their achievements and personalities. From your son getting a sticker for exceptional performance in school to your husband wearing a label proclaiming that he gave blood today, stickers can be an honor to wear, but a nightmare to remove when you accidentally wash the shirt and dry the sticker in place. A number of methods will help you unstick the sticker after it has made a trip through the dryer.. ...
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Was just speaking to my mum today and she remembered being gifted a teapot set a good 20 years ago. She sent me a pic of a sticker that fell off since it has just been sitting there (note it is not the pot that she put it on to take the photo). I live in a different city so cant speak to the authenticity of the tea pot/setting, but thought it might add to the little sticker collection. It seems to add something new as there is no dash between Yixing and China as per the other stickers and the font of the characters at the bottom of the black half seems to be the tallest without having the square look of the yellow sticker ...
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Originally Posted by Autonorm For removing stickers try using some rubbing alcohol. It should dissolve the glue and the sticker should come off easily. The film wont be destroyed and the alcohol will
0043] The bioactive agent which is dispersed with the PEA can be any agent which is a therapeutic, prophylactic, or diagnostic agent. These agents can have antiproliferative or anti-inflammatory properties or can have other properties such as antineoplastic, antiplatelet, anti-coagulant, anti-fibrin, antithrombotic, antimitotic, antibiotic, antiallergic, or antioxidant properties. Moreover, these agents can be cystostatic agents, agents that promote the healing of the endothelium, or agents that promote the attachment, migration and proliferation of endothelial cells while quenching smooth muscle cell proliferation. Examples of suitable therapeutic and prophylactic agents include synthetic inorganic and organic compounds, proteins and peptides, polysaccharides and other sugars, lipids, and DNA and RNA nucleic acid sequences having therapeutic, prophylactic or diagnostic activities. Nucleic acid sequences include genes, antisense molecules, which bind to complementary DNA to inhibit ...
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Leu Gln Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys 610 615 620Val Glu Pro Lys Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr625 630 635 640Lys Gly Ser Thr Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val 645 650 655Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser 660 665 670Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 675 680 685Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys 690 695 700Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu705 710 715 720Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro 725 730 735Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr 740 745 750Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe 755 760 765Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn 770 775 780Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp785 790 795 800Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val 805 810 815Pro Thr His Tyr Tyr Ser Ile Ile ...
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Mix 3 tbsp. of regular gelatin with 1 tbsp. of hot water to make a sticky liquid. Paint this mixture onto the back of cut out pictures or artwork. Do not handle the stickers until the gelatin has set, but also make sure the gelatin has not completely dried. Place the stickers on surfaces and remove them whenever desired. To reapply the stickers, dampen the back of the stickers with water and reuse them.. ...
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If S. aureus is methicillin-susceptible then cefazolin 2 g IV q8h or nafcillin 2 g IV q4h are the antibiotics of choice. Obtain bone biopsy to determine microbiologic cause prior to initiation of antimicrobial therapy if blood cultures are negative and patient clinically stable.. ...
Susceptibility of Anaerobic Bacteria to Cefoxitin and Related Compounds: Cephalothin, cefazolin, cephradine, and cefoxitin inhibited more than 75% of 326 anaero
Klebsiella oxytoca (K. oxytoca) is a Gram-negative microbe generally associated with community and hospitalacquired infections. Due to its clinical significance, we evaluated the effect of biofield treatment on phenotype and biotype characteristics of K. oxytoca (ATCC 43165). The study was performed into three groups i.e. C (control), T1 (treatment, revived); and T2 (treatment, lyophilized). Subsequently, groups T1 and T2 were received biofield treatment and control group was remained as untreated. The antimicrobial sensitivity results showed 3.33% and 6.67% alteration in antimicrobials susceptibility in group T1 cells on day 5 and 10, respectively, and 3.33% alteration in antimicrobials susceptibility was observed in group T2 cells on day 10 as compared to control. The sensitivity patterns of cefazolin were changed from resistant (R) to intermediate (I) on day 5, and resistance (R) to susceptible (S) on day 10, in T1 cells of K. oxytoca. The MIC value of cefazolin was decreased by 2-fold in ...
Case Report: A 69-year-old man was admitted to the hospital after undergoing radical prostatectomy. The patient was given perioperative, intravenous cefazolin. On postoperative day 2, the patient developed an ileus and oliguric renal failure. Two days later, the patient developed a temperature of 101 °F and began receiving piperacillin-tazobactam treatment for hospital-acquired pneumonia. Three days after starting the treatment, the patient developed hypotension; worsening abdominal distention, and foul-smelling, watery diarrhea. The patient was subsequently transferred to the intensive care unit, given intravenous metronidazole for possible C. difficile infection, and put on vasopressors to stabilize his blood pressure. Continuous venovenous hemofiltration was initiated on postoperative day 10. The next day, rectal vancomycin treatment was started and piperacillin-tazobactam therapy was discontinued when a C. difficile toxin was detected. A sigmoidoscopy performed on postoperative day 24 ...
This study evaluates and compares the effects of enamel prophylaxis using either oil-free pumice or oil-containing prophylaxis paste on the incidence of bracket failure in orthodontic patients.. Forty-six orthodontic patients participated in this prospective clinical trial. A cross-mouth method was used in each patient, in which two diagonal quadrants (i.e. upper right and lower left or vice versa) were randomly assigned to the pumice group and the contralateral diagonal quadrants to the Prophy Paste (R) group. A total of 836 teeth were bonded using Transbond XT (3M Unitek) and monitored for an average of 23 months for bond failure. Chi-square analysis was used to compare the number of bracket failures between the groups.. Overall, 26 bond failures occurred by the end of the trial. Fifteen bracket failures were observed in the Prophy Paste group (3.6%) and 11 in the pumice group (2.6%). The failure rates were fairly evenly distributed between the upper and lower jaws. There were no statistically ...
TY - JOUR. T1 - The value of prophylactic antibiotics for simple lacerations. AU - Thirlby, R. C.. AU - Blair, A. J.. AU - Thal, E. R.. PY - 1983/1/1. Y1 - 1983/1/1. N2 - The use of prophylactic antibiotics as an adjunct to suture closure of simple lacerations is common; however, little data exist to support this practice. Orally administered antibiotics are routinely given after wound closure. This prophylactic antibiotic regimen violates an established surgical principle, namely, the early use of antibiotics to establish adequate preoperative tissue levels. Despite this knowledge, antibiotics continue to be prescribed for patients with simple lacerations. Drug cost, patient compliance, the risk of allergy and bacterial resistance are additional considerations. For these reasons, this study was undertaken to determine the efficacy of antibiotic prophylaxis as practiced in many communities today.. AB - The use of prophylactic antibiotics as an adjunct to suture closure of simple lacerations is ...
There is no consensus on the use of prophylactic antibiotics in plastic surgery to prevent postoperative infection. This study was performed to investigate whether the use of prophylactic antibiotics has an effect on postoperative infection rate. A total of 500 patients were classified into 3 groups based on their diagnosis. Approximately half of the cases received amoxicilin/clavulanate combination the other half had no antibiotics. Wound infection was observed in the post operative period. According to our clinical findings, antibiotic prophylaxis is not necessary in plastic surgery in all patients. We did not find significant difference between the antibiotic prophylaxis and placebo group ...
3. Antibiotics That Act on Cell Wall Biosynthesis B 43 O R1 S N H O N R2 COO- Category 1. First Generation R1 Cephalothin O S Cephazolin R2 O N N N N N N S S 2. Second Generation Cefamandole N N N N S OH Cefuroxime O O N O O Cefoxitin O S NH2 O 3. Third Generation N Cefotaxime H2N O S N N Ceftriaxone H2N S S N N O N O N OH N Ceftazidime H2N +N S N 4. 18 Continued. This has led to multiple waves of semisynthetic ␤-lactams over the 50 years of their clinical use. Scholar and Pratt (2000) note five categories of penicillins (Fig. Second Generation Cefamandole N N N N S OH Cefuroxime O O N O O Cefoxitin O S NH2 O 3. Third Generation N Cefotaxime H2N O S N N Ceftriaxone H2N S S N N O N O N OH N Ceftazidime H2N +N S N 4. 18 Continued. This has led to multiple waves of semisynthetic ␤-lactams over the 50 years of their clinical use. Scholar and Pratt (2000) note five categories of penicillins (Fig. 18A) based on narrow- versus broad-spectrum activities and whether there is antipseudomonal activity. ...

Cefazolin - WikipediaCefazolin - Wikipedia

Cefazolin levels are not significantly affected by liver disease. As with other antibiotics, cefazolin may interact with other ... Caution should be used in breastfeeding as a small amount of cefazolin enters the breast milk. Cefazolin can be used ... Some important drugs that may interact with cefazolin such as probenecid. Side effects associated with use of cefazolin therapy ... Cefazolin is used in a variety of infections provided that susceptible organisms are involved. It is indicated for use in the ...
more infohttps://en.wikipedia.org/wiki/Cefazolin

Cefazolin Injection: MedlinePlus Drug InformationCefazolin Injection: MedlinePlus Drug Information

Cefazolin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use cefazolin injection until you finish the prescription, even if you feel better. If you stop using cefazolin injection too ... Before taking cefazolin injection,. *tell your doctor and pharmacist if you are allergic to cefazolin; carbapenem antibiotics; ... Cefazolin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *genital ...
more infohttps://medlineplus.gov/druginfo/meds/a682731.html

cefazolin (injection) | Cignacefazolin (injection) | Cigna

Cefazolin is used to treat many kinds of bacterial infections, including severe or life-threatening forms. Cefazolin may also ... Cefazolin is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. ... What is cefazolin?. Cefazolin is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. ... What is the most important information I should know about cefazolin?. You should not use cefazolin if you have ever had a ...
more infohttps://www.cigna.com/healthwellness/hw/medications/cefazolin-d00007a1

Cefazolin - WikipediaCefazolin - Wikipedia

Cefazolin je organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 454,507 Da.[6][7] ... Dobavljeno iz "https://sh.wikipedia.org/w/index.php?title=Cefazolin&oldid=33586003" ...
more infohttps://sh.wikipedia.org/wiki/Cefazolin

CeFAZolin (Professional Patient Advice) - Drugs.comCeFAZolin (Professional Patient Advice) - Drugs.com

Professional guide for CeFAZolin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions ... Cefazolin crosses the placenta. Adverse events have not been reported in the fetus following administration of cefazolin prior ... Guidelines suggest nighttime levels of intraperitoneal cefazolin may fall below the MIC of most organisms and adding cefazolin ... IV cefazolin is a preferred agent for treatment of children with CAP due to MSSA. To potentially reduce morbidity and mortality ...
more infohttps://www.drugs.com/ppa/cefazolin.html

Cefazolin Sodium Injection | Lifescript.comCefazolin Sodium Injection | Lifescript.com

Learn about cefazolin side effects, how to take cefazolin and more. ... Before administering cefazolin,. *tell your doctor and pharmacist if you are allergic to cefazolin, any other cephalosporin [e. ... Your health care provider probably will give you a several-day supply of cefazolin at a time. If you are receiving cefazolin ... Cefazolin may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away: ...
more infohttp://www.lifescript.com/health/centers/heart_health/drugs/cefazolin_sodium_injection.aspx

Cefazolin - Substance Information - ECHACefazolin - Substance Information - ECHA

About this substance This section provides an overview of the volume in which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from REACH registered dossiers provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance dossier.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety ...
more infohttps://echa.europa.eu/substance-information/-/substanceinfo/100.043.042

Cefazolin - Adventist HealthCareCefazolin - Adventist HealthCare

Common brand names: Ancef, Kefzol Summary of Interactions with Vitamins, Herbs, & Foods What Are Nutrient Interactions Types of interactions: Beneficial Adverse Check Replenish Depleted Nutrients Folic Acid Tetracycline can interfere with the activity of folic acid, potassium, and vitamin B2, vitamin B6, vitamin B12...
more infohttps://www.adventisthealthcare.com/health/library/topic/?id=hn-10000822

cefazolin injection : Rate your experience with this treatmentcefazolin injection : Rate your experience with this treatment

Rate your experience with cefazolin injection on - WebMD including the side effects, drug interactions, effectiveness, ease of ...
more infohttps://www.webmd.com/drugs/drugreviewpost-11037-cefazolin+injection.aspx?post=new&drugid=11037&drugname=cefazolin+injection

Cefazolin Side Effects in Detail - Drugs.comCefazolin Side Effects in Detail - Drugs.com

Learn about the potential side effects of cefazolin. Includes common and rare side effects information for consumers and ... Applies to cefazolin: injection powder for solution, injection solution. Along with its needed effects, cefazolin may cause ... Kefzol (cefazolin)." Lilly, Eli and Company, Indianapolis, IN. 4. "Product Information. Ancef (cefazolin)." SmithKline Beecham ... Applies to cefazolin: injectable powder for injection, injectable solution, intravenous powder for injection, intravenous ...
more infohttps://www.drugs.com/sfx/cefazolin-side-effects.html

Cefazolin (Injection Route) Before Using - Mayo ClinicCefazolin (Injection Route) Before Using - Mayo Clinic

Information about this cefazolin-injection-route. Pregnancy Category. Explanation. All Trimesters. B. Animal studies have ... Because of cefazolins toxicity, use in newborn and premature babies is not recommended. ... Undernourished condition-May be worsened by cefazolin and you may need to take Vitamin K. ... which may require caution and an adjustment in the dose for patients receiving cefazolin. ...
more infohttps://www.mayoclinic.org/drugs-supplements/cefazolin-injection-route/before-using/drg-20073267

Tissue Concentrations of Cefazolin in Man | SpringerLinkTissue Concentrations of Cefazolin in Man | SpringerLink

The antimicrobial efficacy of cefazolin was tested in human patients undergoing urological operations. Concentrations in serum ... 2 g of cefazolin given in a short infusion of 25 min reached a peak concentration in muscle tissue of 20 ug/g. This ... Cefazolin is known as cephalosporin C derivate with a wide range of activity against gram-positive and gram-negative ... Sinagowitz E., Pelz K., Burgert A., Kaczkowski W., Sommerkamp H., Westenfelder M. (1976) Tissue Concentrations of Cefazolin in ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-3126-1_48

Cefazolin - edren.orgCefazolin - edren.org

Cefazolin is an alert antibiotic, an alert antibiotic form will need to be completed and sent to pharmacy along with a pharmacy ...
more infohttp://edren.org/ren/handbook/unithdbk/prescribing/renal-drugs-a-z/cefazolin/

Sicef (Cefazolin Sodium) BenedettiSicef (Cefazolin Sodium) Benedetti

Sicef information about active ingredients, pharmaceutical forms and doses by Benedetti, Sicef indications, usages and related health products lists
more infohttp://drugs-about.com/drugs-s/sicef-benedetti.html

cefazolin (injection) - WellSpan Health Librarycefazolin (injection) - WellSpan Health Library

Cefazolin is also used to help prevent infection in people having certain types of surgery. Cefazolin may also be used for ... Cefazolin is a cephalosporin (SEF a low spor in) antibiotic that is is used to treat bacterial infections, including severe or ... What is cefazolin?. Cefazolin is a cephalosporin (SEF a low spor in) antibiotic that is is used to treat bacterial infections, ... What is the most important information I should know about cefazolin?. You should not use cefazolin if you have ever had a ...
more infohttps://www.wellspan.org/health-library/Document.aspx?id=d00007a1

Cefazolin (Injection Route) Description and Brand Names - Mayo ClinicCefazolin (Injection Route) Description and Brand Names - Mayo Clinic

Cefazolin is used to treat bacterial infections in many different parts of the body. This medicine is also given before certain ... Cefazolin belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing ...
more infohttps://www.mayoclinic.org/drugs-supplements/cefazolin-injection-route/description/drg-20073267

CEFAZOLIN-DARNITSACEFAZOLIN-DARNITSA

It is used to treat infections caused by organisms susceptible to cefazolin:- respiratory tract infections; genitourinary ...
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Stancef (Cefazolin Sodium) Biomedis InternationalStancef (Cefazolin Sodium) Biomedis International

Injectable; Injection; Cefazolin Sodium 1 g*Injectable; Injection; Cefazolin Sodium 500 mg. ...
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Cefazolin in the treatment of acute enteric fever.Cefazolin in the treatment of acute enteric fever.

Cefazolin was used in the treatment of nine patients with acute enteric fever proven by positive blood cultures. In seven ... Cefazolin was administered either intramuscularly or intravenously in a daily dose of 3 to 6 g for 11 to 16 days. The mean peak ... Cefazolin was used in the treatment of nine patients with acute enteric fever proven by positive blood cultures. In seven ... Cefazolin / administration & dosage, pharmacology, therapeutic use*. Cephalosporins / therapeutic use*. Clinical Trials as ...
more infohttp://www.biomedsearch.com/nih/Cefazolin-in-treatment-acute-enteric/791088.html

Cefazolin Irreversibly Inhibits Proliferation and Migration of Human Mesenchymal Stromal CellsCefazolin Irreversibly Inhibits Proliferation and Migration of Human Mesenchymal Stromal Cells

and 1000 μg/mL cefazolin (2.91 × 105 cells, ) was still significantly reduced (Figure 3(b)). Treatment for 48 h with cefazolin ... Cefazolin Irreversibly Inhibits Proliferation and Migration of hMSC. MSC cell lines treated with cefazolin for 24 h and 48 h ... After 72 h of cefazolin treatment, all cells treated with cefazolin showed a significantly lowered cell count, at 1000 μg/mL ... Cefazolin Affects MSC Cell Count. Studying cell lines treated with cefazolin at five different concentrations after 24, 48, and ...
more infohttps://www.hindawi.com/journals/bmri/2016/2042687/

Cefazolin potency against methicillin-resistant Staphylococcus aureus: | IDRCefazolin potency against methicillin-resistant Staphylococcus aureus: | IDR

Results: The cefazolin MIC inhibiting 50% of the isolates was 64 mg/L; 81% had MICs â ¤128 and nearly all (99.9%) had MICs â ¤ ... Materials and methods: We assessed the potency of cefazolin against a collection of 1,239 MRSA from 42 US hospitals using ... While the currently defined cefazolin MRSA phenotypic profile precludes the use of parenteral administration, techniques that ... Keywords: methicillin-resistant, Staphylococcus aureus, ultrasonic, infection, cefazolin ...
more infohttps://www.dovepress.com/cefazolin-potency-against-methicillin-resistant-staphylococcus-aureus--peer-reviewed-article-IDR

Cefazolin | definition of cefazolin by Medical dictionaryCefazolin | definition of cefazolin by Medical dictionary

... cefazolin explanation free. What is cefazolin? Meaning of cefazolin medical term. What does cefazolin mean? ... Looking for online definition of cefazolin in the Medical Dictionary? ... cefazolin. Also found in: Dictionary, Acronyms, Wikipedia.. Related to cefazolin: cephalexin cefazolin. [sĕ-faz´o-lin] a ... The most common combinations were 6% cefazolin with ciprofloxacin, 3% cefazolin with TMP-SMX, 2% cefazolin with gentamicin, and ...
more infohttp://medical-dictionary.thefreedictionary.com/cefazolin

Cefazolin (By injection) | Lima Memorial Health SystemCefazolin (By injection) | Lima Memorial Health System

PremierPro Rx ceFAZolin, ceFAZolin Novaplus. There may be other brand names for this medicine.. When This Medicine Should Not ... Cefazolin (By injection). Cefazolin Sodium (sef-A-zoe-lin SOE-dee-um). Treats or prevents serious infections caused by bacteria ... Do not use it if you had an allergic reaction to cefazolin or any other cephalosporin antibiotic.. How to Use This Medicine: ... Some medicines can affect how cefazolin works. Tell your doctor if you are taking probenecid or a blood thinner, such as ...
more infohttp://www.limamemorial.org/health-library/Thomson%20DrugNotes/45/0632

Sagent Pharmaceuticals Launches Cefazolin for Inje... (     SCHAUMBURG Ill. March 13 /- Sagen...)Sagent Pharmaceuticals Launches Cefazolin for Inje... ( SCHAUMBURG Ill. March 13 /- Sagen...)

The launch of Cefazolin the first product to emerge from ourextensi...About Cefazolin ...,Sagent,Pharmaceuticals,Launches, ... Cefazolin,for,Injection,,USP,biological,advanced biology technology,biology laboratory technology,biology device technology, ... March 13 /- Sagent Pharmaceuticals...The introduction of Cefazolin for injection marks the second productl... ... About Cefazolin Cefazolin for injection, USP, is the generic equivalent of GlaxoSmithKlines ANCEF(R), an antibiotic used to ...
more infohttp://www.bio-medicine.org/biology-technology-1/Sagent-Pharmaceuticals-Launches-Cefazolin-for-Injection--USP-3933-1/

cefazolin delta-2-methyl ester
     Summary Report | CureHuntercefazolin delta-2-methyl ester Summary Report | CureHunter

cefazolin delta-2-methyl ester: RN given refers to (6R-trans)-isomer; RN for cpd without isomeric designation not available 2/ ... cefazolin delta-2-methyl ester. Subscribe to New Research on cefazolin delta-2-methyl ester ...
more infohttp://www.curehunter.com/public/keywordSummaryC066936-cefazolin-delta-2-methyl-ester.do
  • In seven patients the causative organism was Salmonella typhi and in two it was Salmonella paratyphi B. Minimal inhibitory and minimal bactericidal concentrations of cefazolin against the nine isolates ranged between 1.95 and 3.90 mug/ml. (biomedsearch.com)
  • While it is postulated that these high concentrations may be suitable to treat more resistant organisms such as MRSA, the cefazolin minimum inhibitory concentration (MIC) distribution for this organism is currently unknown. (dovepress.com)
  • The overwhelming majority of MRSA had cefazolin MICs that were considerably lower than achievable tissue concentrations (≥1,000 mg/L) using this novel drug delivery system. (dovepress.com)
  • While the currently defined cefazolin MRSA phenotypic profile precludes the use of parenteral administration, techniques that deliver local exposures in excess of these inhibitory concentrations may provide a novel treatment strategy for skin and skin structure infections. (dovepress.com)
  • Cefazolin has been widely used in surgical prophylaxis, especially in biliary tract (because of the moderately high concentrations achieved in bile), orthopedic, cardiac and gynecological surgery. (chemicalbook.com)
  • Store unmixed cefazolin dry powder at room temperature, away from moisture, heat, and light. (cigna.com)
  • Cefazolin is injected into a muscle or into a vein through an IV. (cigna.com)
  • Cefazolin is given as an infusion into a vein. (wellspan.org)
  • In our institution, second-generation cephalosporin results are reported only if the organism is resistant to cefazolin , and third-generation drugs are reported only if the isolate is resistant to both cefoxitin and cefamandole. (thefreedictionary.com)
  • Listeria Cefazolin is pregnancy category B, indicating general safety for use in pregnancy. (wikipedia.org)
  • Caution should be used in breastfeeding as a small amount of cefazolin enters the breast milk. (wikipedia.org)
  • Cefazolin can pass into breast milk and may harm a nursing baby. (cigna.com)
  • We studied the proliferation and migration capacity of primary hMSC during cefazolin treatment at various doses for up to 3 days, as well as the reversibility of the effects during the subsequent 3 days of culture without the drug. (hindawi.com)
  • What other drugs will affect cefazolin? (wellspan.org)
  • Other drugs may affect cefazolin, including prescription and over-the-counter medicines, vitamins, and herbal products. (wellspan.org)
  • 2 g of cefazolin given in a short infusion of 25 min reached a peak concentration in muscle tissue of 20 ug/g. (springer.com)
  • If long-term administration is required and delayed bone healing is present, cefazolin application must be considered as a cause of delayed bone healing. (hindawi.com)
  • To better understand the effect of cefazolin on the early stages of bone healing, the modulation of cell migration and proliferation and its reversibility was evaluated and compared to cell cultures without drug administration. (hindawi.com)
  • Neurology Sewice Veterans Administration Medical Center and the Department of Neurology Georgetown University School of Medicine Washington, DC References Cefazolin-Induced Encephalopathy in a Uremic Patient John D. Schwankhaus, MD, Elmo F. Masucci, MD, and John F. Kurtzke, MD A 62-year-old man was admitted to the hospital with renal failure resulting from urinary obstruction. (docme.ru)
  • Baxter International Inc. (NYSE: BAX) and Water Street Healthcare Partners announced the United States Food and Drug Administration (FDA) has approved CEFAZOLIN Injection in GALAXY Container (2 g/100 mL), which is Baxter's flexible container that uses the company's proprietary aseptic filling manufacturing processes. (baxter.com)
  • Tell any doctor who treats you that you are using cefazolin. (cigna.com)