Cefamandole: Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.Mandelic Acids: Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Cephalothin: A cephalosporin antibiotic.Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.Cephapirin: Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.CephalosporinaseMicrobial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Cefonicid: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Enterobacteriaceae: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.Cephaloridine: A cephalosporin antibiotic.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.Cephamycins: Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.Moxalactam: Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.Premedication: Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.Hypoprothrombinemias: Absence or reduced levels of PROTHROMBIN in the blood.Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Enterobacter: Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Staphylococcus: A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Proteus: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.Sarcina: A genus of gram-positive, anaerobic bacteria whose organisms divide in three perpendicular planes and occur in packets of eight or more cells. It has been isolated from soil, grains, and clinical specimens.Cefotaxime: Semisynthetic broad-spectrum cephalosporin.Penicillinase: A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Names: Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.Cefotetan: A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Markedly different rates and resistance profiles exhibited by seven commonly used and newer beta-lactams on the selection of resistant variants of Enterobacter cloacae. (1/187)

Seven beta-lactam antibiotics (cefepime, cefoperazone, ceftazidime, ceftriaxone, cefamandole, imipenem and meropenem) were tested for their potential to select resistance in standard and clinical strains of Enterobacter cloacae (n = 9). The strains were subcultured daily with the test antibiotics at doubling concentrations starting at 0.125 x MIC. Development of resistance throughout the passages was detected by a disc diffusion test. Ceftazidime, ceftriaxone and cefamandole selected resistance at a faster rate than cefoperazone, cefepime and meropenem. Imipenem did not select resistance in the nine strains tested and was the only antibiotic that eradicated all the strains during selection. The resistance patterns of strains selected by meropenem, cefepime and the other cephalosporins were markedly different, although cross-resistance to the early generation cephalosporins was common. The resistance phenotypes of most strains remained stable upon serial passages in antibiotic-free medium. The findings of this study highlight the importance of the choice of antibiotic for therapy not only on the basis of its antibacterial activity, but also on its potential to select resistance to itself and other antibiotics.  (+info)

Interpretive criteria for cefamandole and cephalothin disk diffusion susceptibility tests. (2/187)

A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably.  (+info)

Quinupristin-dalfopristin combined with beta-lactams for treatment of experimental endocarditis due to Staphylococcus aureus constitutively resistant to macrolide-lincosamide-streptogramin B antibiotics. (3/187)

Quinupristin-dalfopristin (Q-D) is an injectable streptogramin active against most gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). In experimental endocarditis, however, Q-D was less efficacious against MRSA isolates constitutively resistant to macrolide-lincosamide-streptogram B (C-MLS(B)) than against MLS(B)-susceptible isolates. To circumvent this problem, we used the checkerboard method to screen drug combinations that would increase the efficacy of Q-D against such bacteria. beta-Lactams consistently exhibited additive or synergistic activity with Q-D. Glycopeptides, quinolones, and aminoglycosides were indifferent. No drugs were antagonistic. The positive Q-D-beta-lactam interaction was independent of MLS(B) or beta-lactam resistance. Moreover, addition of Q-D at one-fourth the MIC to flucloxacillin-containing plates decreased the flucloxacillin MIC for MRSA from 500 to 1,000 mg/liter to 30 to 60 mg/liter. Yet, Q-D-beta-lactam combinations were not synergistic in bactericidal tests. Rats with aortic vegetations were infected with two C-MLS(B)-resistant MRSA isolates (isolates AW7 and P8) and were treated for 3 or 5 days with drug dosages simulating the following treatments in humans: (i) Q-D at 7 mg/kg two times a day (b.i.d.) (a relatively low dosage purposely used to help detect positive drug interactions), (ii) cefamandole at constant levels in serum of 30 mg/liter, (iii) cefepime at 2 g b.i.d., (iv) Q-D combined with either cefamandole or cefepime. Any of the drugs used alone resulted in treatment failure. In contrast, Q-D plus either cefamandole or cefepime significantly decreased valve infection compared to the levels of infection for both untreated controls and those that received monotherapy (P < 0.05). Importantly, Q-D prevented the growth of highly beta-lactam-resistant MRSA in vivo. The mechanism of this beneficial drug interaction is unknown. However, Q-D-beta-lactam combinations might be useful for the treatment of complicated infections caused by multiple organisms, including MRSA.  (+info)

In vitro activity of piperacillin compared with that of carbenicillin, ticarcillin, ampicillin, cephalothin, and cefamandole against Pseudomonas aeruginosa and Enterobacteriaceae. (4/187)

Piperacillin (T-1220), a semisynthetic derivative of aminobenzylpenicillin, was more active than either carbenicillin or ticarcillin against Pseudomonas aeruginosa; over 60% of isolates were inhibited at a concentration of 6.3 mug/ml. Piperacillin was bactericidal for 84% of Pseudomonas strains at 100 mug/ml, carbenicillin killed 60%, and ticarcillin killed 68% at that concentration. Piperacillin was also more active than the other penicillins against isolates of Escherichia coli, Enterobacter, and Proteus mirabilis. The combination of piperacillin and tobramycin, demonstrating synergistic inhibition of 87% of strains of P. aeruginosa, was the most active of the penicillin-aminoglycoside combinations tested for synergism.  (+info)

In-vitro bactericidal activity of cefpirome and cefamandole in combination with glycopeptides against methicillin-resistant Staphylococcus aureus. (5/187)

The bactericidal activity in vitro of cefpirome plus either vancomycin or teicoplanin was compared with that of a cefamandole-vancomycin combination against ten clinical isolates of homogeneous methicillin-resistant Staphylococcus aureus. Cefpirome (0.125 x MIC) combined with vancomycin (0.5-2 x MIC) or teicoplanin (0.5-4 x MIC) acted synergically against the ten isolates. Similar effects were observed with the cefamandole-vancomycin combination, except that for one isolate, higher cefamandole concentrations (0.25-1 x MIC) were required.  (+info)

The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone. (6/187)

Thirteen patients undergoing total hip replacement were given ceftriaxone 1 g and cefamandole 1 g simultaneously, either immediately or 8 h before surgery. For both agents the concentrations seen in the bone and fat during the operation, and for haematoma fluid +info)

Antibacterial activity of a new parenteral cephalosporin--HR 756: comparison with cefamandole and ceforanide. (7/187)

HR 756, a new parenteral cephalosporin that is beta-lactamase resistant, was tested against 271 bacterial isolates. Both agar and broth dilution testing were employed, using two media and two inoculum sizes of bacteria. Antibacterial activity of the drug was compared to that of cefamandole (CFM) and ceforanide (CFN). In agar, HR 756 was more active than CFM and CFN against all bacteria tested except isolates of Staphylococcus aureus, which were better inhibited by CFM. HR 756 exhibited some antipseudomonas activity in agar, although a marked inoculum effect was apparent. A comparison of median minimum inhibitory and bactericidal concentrations in broth showed again that HR 756 was the most active of these three drugs. HR 756 demonstrated enhanced antibacterial activity compared to CFM and CFN against bacteria sensitive to all three drugs as well as against more resistant isolates of Serratia marcescens, Enterobacter species, and indole-positive Proteus. As with other cephalosporins, results for most bacteria were affected by inoculum size, medium, and type of dilution test employed in in vitro studies.  (+info)

Effect of osmotic stabilizers on radiometric detection of cell wall-damaged bacteria. (8/187)

The effect of osmotic stabilizers on the 14CO2-dependent radiometric detection of cell wall-damaged Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa was studied in BACTEC 14C-labeled blood culture medium. The organisms were previously exposed to cefamandole or carbenicillin at 63 to 80% of the minimum inhibitory concentrations. The addition of 10% sucrose, 2.2% glycerol, and 2.2% ethylene glycol to the medium failed to reduce the time required for detection and diminished the amounts of 14CO2 released by the growing cultures. Viable counts made after 4 to 7 h of incubation showed a decreased culture density in osmotically stabilized media as compared with saline or Ficoll controls. Sucrose and Ficoll had little or no inhibitory effect on 14CO2 evolution by P. aeruginosa. The osmotic stabilizers tested did not seem to improve the survival of the bacterial inoculum and failed to increase the sensitivity of the radiometric system of detection.  (+info)

*Cefamandole

... is no longer available in the United States. The chemical structure of cefamandole, like that of several other ... The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. ... Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, ... The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms. Escherichia coli: ...

*Cephalosporin

These include latamoxef (moxalactam), cefmenoxime, cefoperazone, cefamandole, cefmetazole, and cefotetan. This is thought to be ...

*Beta-lactamase

Sanders CC, Sanders WE (June 1979). "Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta- ...

*Cefonicid

Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v. Cefonicid is synthesized conveniently by ... The mandelic acid amide C-7 side chain is reminiscent of cefamandole. Cefazaflur Saltiel, E; Brogden, R. N. (1986). "Cefonicid ...

*Haemophilus influenzae biogroup aegyptius

These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ...

*Vitamin K

Other drugs associated with vitamin K deficiency include salicylates, barbiturates, and cefamandole, although the mechanisms ...

*Cefradine

Cephapirin Cephacetrile Cefamandole Ampicillin (Has the same chemical formula) Penicillin is the usual drug of choice in the ...

*List of β-lactam antibiotics

Cefaclor Cefamandole Cefuroxime Cefotetan Cefoxitin Cefixime Cefotaxime Cefpodoxime Ceftazidime Ceftriaxone (With β-lactamase ...

*List of MeSH codes (D02)

... cefamandole MeSH D02.065.589.099.249.150.160 --- cefoperazone MeSH D02.065.589.099.249.160 --- cefazolin MeSH D02.065.589.099. ...

*Disulfiram-like drug

Abacavir Cephalosporins such as cefamandole, cefmenoxime, cefmetazole, cefonicid, cefoperazone, cefotetan, ceftriaxone, ...

*List of drugs: Cb-Ce

... cefamandole (INN) Cefanex cefaparole (INN) cefapirin (INN) cefatrizine (INN) cefazaflur (INN) cefazedone (INN) cefazolin (INN) ...

*Disulfiram

... cefamandole and cefotetan, that have a N-methylthio-tetrazole moiety Griseofulvin, an oral antifungal drug Procarbazine ...

*ATC code J01

Cefradine J01DB10 Cefacetrile J01DB11 Cefroxadine J01DB12 Ceftezole J01DC01 Cefoxitin J01DC02 Cefuroxime J01DC03 Cefamandole ...

*Timeline of antibiotics

... cefamandole 1977 - cefoxitin 1977 - cefuroxime 1977 - mezlocillin 1977 - pivmecillinam 1979 - cefaclor 1980 - cefmetazole 1980 ...
Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained during a pilot study to investigate the pharmacokinetics of the drug cefamandole. Plasma concentrations of the drug were measured on six healthy volunteers at 14 time points following an intraveneous dose of 15 mg/kg body weight of cefamandole. ...
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3. Antibiotics That Act on Cell Wall Biosynthesis B 43 O R1 S N H O N R2 COO- Category 1. First Generation R1 Cephalothin O S Cephazolin R2 O N N N N N N S S 2. Second Generation Cefamandole N N N N S OH Cefuroxime O O N O O Cefoxitin O S NH2 O 3. Third Generation N Cefotaxime H2N O S N N Ceftriaxone H2N S S N N O N O N OH N Ceftazidime H2N +N S N 4. 18 Continued. This has led to multiple waves of semisynthetic ␤-lactams over the 50 years of their clinical use. Scholar and Pratt (2000) note five categories of penicillins (Fig. Second Generation Cefamandole N N N N S OH Cefuroxime O O N O O Cefoxitin O S NH2 O 3. Third Generation N Cefotaxime H2N O S N N Ceftriaxone H2N S S N N O N O N OH N Ceftazidime H2N +N S N 4. 18 Continued. This has led to multiple waves of semisynthetic ␤-lactams over the 50 years of their clinical use. Scholar and Pratt (2000) note five categories of penicillins (Fig. 18A) based on narrow- versus broad-spectrum activities and whether there is antipseudomonal activity. ...
The model itself though, was less to my linking. It goes way too low at the later times. Upon consideration, since the model assumes homoscedastic error it does not matter to the likelihoood if the fit at the lower end is not so good. After all, an error of 1 is nothing compared to errors of 10 or 20 at the upper end of the scale. In addition it can be argued that the error is not homoscedastic. If it were homoscedastic, the underlying data would show way more variation at the lower end of the scale. It would need confirmation from the measuring team, but for now I will assume proportional error ...
This page includes the following topics and synonyms: Second Generation Anti-anaerobe Cephalosporins, Cefoxitin, Cefotetan, Cefamandole.
Professional guide for CeFAZolin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
isolated from preterm neonates during the outbreak of gastroenteritis in hospital in Nairobi, Kenya, were resistance to trimethoprin-sulfathoxaxole, Chloramphenicol, oxytetracycline and ampicilin, but only a few strains were resistant to cefazolin, cefamandole, cefataximine, amikacin and nalidixic acid. Fourteen different antimicrobial resistance patterns were observed in the 229 strains of E.coli analyzed. Eighty-two percent of the EPEC strains belonged to two resistance patterns. There was no consistent relationship between palsmid profile group and antimicrobial resistance pattern, although one resistance pattern was more frequently observed in EAF-positive strins belonging to the dominant plasmid profile group. Nine percent of the EPEC strins were resistant to gentamicin compared to 37% in the non-EPEC group. No correlation was observed between administration of gentamicin and percentage of resistant strains isolated. None of the nine neonates receiving gentamicin died during the outbreak. ...
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Synonyms for cephalothin in Free Thesaurus. Antonyms for cephalothin. 2 words related to cephalothin: cephalosporin, Mefoxin. What are synonyms for cephalothin?
cefazolin delta-2-methyl ester: RN given refers to (6R-trans)-isomer; RN for cpd without isomeric designation not available 2/91; structure given in first source
Cefazolin is administered parentrally .It reaches high concentrations in plasma and bile.Cefazolin has a longer half life( 2 hrs )hence used in surgical prophylaxis.80 % is protein bound. 90 % is excreted in the urine.
These are the modules currently offered on this course in the 2019-20 academic year.. You can also view the modules offered in the years: 2018-19; 2020-21.. Find out more about studying and applying for this degree.. ...
Looking for online definition of cefazolin in the Medical Dictionary? cefazolin explanation free. What is cefazolin? Meaning of cefazolin medical term. What does cefazolin mean?
ceph·a·lo·thin (sĕfʹə lə thĭn) n. A semisynthetic analogue of cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally and used especially to treat systemic infections caused by susceptible microorganisms. …
Warfarin has been reported to interact with more than 100 drugs, including many antibiotics. Warfarin is a racemic mixture of S- and R-warfarin enantiomers. S-warfarin is considered to have several times more anticoagulant activity than R-warfarin. S-warfarin is primarily metabolized by CYP2C9, whereas Rwarfarin is metabolized by CYP1A2, CYP2C19, and CYP3A4. Thus, one would expect that drugs inhibiting CYP2C9, and therefore S-warfarin metabolism, would increase the concentration of warfarin and enhance its anticoagulant effect (Table). Other antibiotics have been reported to increase warfarin response. Some?such as moxalactam, cefoperazone, cefamandole, cefotetan, and cefmetazole?appear to inhibit the formation of clotting factors and indirectly increase the effect of warfarin. As with the antibiotics that are inhibitors of CYP2C9, there may be a reasonable mechanism for these purported interactions. For the majority of antibiotics associated with warfarin interactions, however, there is no ...
Looking for online definition of cephalothin sodium in the Medical Dictionary? cephalothin sodium explanation free. What is cephalothin sodium? Meaning of cephalothin sodium medical term. What does cephalothin sodium mean?
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Dr. Menchell responded: Cephalosporin rx. Older studies suggested that there was a 5-7% risk of having a reaction to a cephalosporin if you had a history of |a href="/topics/penicillin-allergy" track_data="{
Cefazolin belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
Cefmenoxime is a medicine available in a number of countries worldwide. A list of US medications equivalent to Cefmenoxime is available on the Drugs.com website.
Synonyms for cefuroxime in Free Thesaurus. Antonyms for cefuroxime. 2 synonyms for cefuroxime: Ceftin, Zinacef. What are synonyms for cefuroxime?
The antimicrobial efficacy of cefazolin was tested in human patients undergoing urological operations. Concentrations in serum and homogenized skeletal muscle were determined by means of the agar...
Buy and view Cefradine, zwitterion cephalosporin antibiotic, 38821-53-3, MSDS. Click to view prices and info for Cefradine on TOKU-E.com
... ! Generic Suprax is used for treating infections caused by certain bacteria. Generic Suprax is a cephalosporin antibiotic. It works by killing sensitive bacteria.
... ! Generic Suprax is used for treating infections caused by certain bacteria. Generic Suprax is a cephalosporin antibiotic. It works by killing sensitive bacteria.
Generic Omnicef 300mg is a cephalosporin antibiotic used to treat of mild to moderate infections. Purchase from InternationalDrugMart and save money.

Cefamandole - WikipediaCefamandole - Wikipedia

Cefamandole is no longer available in the United States. The chemical structure of cefamandole, like that of several other ... The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. ... Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, ... The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms. Escherichia coli: ...
more infohttps://en.wikipedia.org/wiki/Cefamandole

Cefamandole nafate - DrugBankCefamandole nafate - DrugBank

Cefamandole. prodrug. 5CKP8C2LLI. 34444-01-4. OLVCFLKTBJRLHI-AXAPSJFSSA-N. Prescription Products. Name. Dosage. Strength. Route ... Cefamandole nafate. Accession Number. DB14725. Type. Small Molecule. Groups. Approved. Description. Not Available. Structure. ... The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Cefamandole nafate. ... The risk or severity of bleeding can be increased when Cefamandole nafate is combined with (R)-warfarin. ...
more infohttps://www.drugbank.ca/drugs/DB14725

R: Pharmacokinetics of CefamandoleR: Pharmacokinetics of Cefamandole

Cefamandole {nlme}. R Documentation. Pharmacokinetics of Cefamandole. Description. The Cefamandole. data frame has 84 rows and ... plot(Cefamandole) fm1 ,- nlsList(SSbiexp, data = Cefamandole) summary(fm1) [Package nlme version 3.1-80 Index] ... a numeric vector giving the observed plasma concentration of cefamandole (mcg/ml). Details. Davidian and Giltinan (1995, 1.1, p ... 2) describe data obtained during a pilot study to investigate the pharmacokinetics of the drug cefamandole. Plasma ...
more infohttp://astrostatistics.psu.edu/su07/R/library/nlme/html/Cefamandole.html

Cefamandole | definition of cefamandole by Medical dictionaryCefamandole | definition of cefamandole by Medical dictionary

... cefamandole explanation free. What is cefamandole? Meaning of cefamandole medical term. What does cefamandole mean? ... Looking for online definition of cefamandole in the Medical Dictionary? ... cefamandole. Also found in: Wikipedia. cefamandole. [sef″ah-man´dōl] a semisynthetic broad-spectrum second-generation ... cefamandole. A CEPHALOSPORIN ANTIBIOTIC drug. A brand name is Kefadol.. cefamandole. a second generation cephalosporin ...
more infohttps://medical-dictionary.thefreedictionary.com/cefamandole

cefamandole injection Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfactioncefamandole injection Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfaction

Find user ratings and reviews for cefamandole injection on WebMD including side effects and drug interactions, medication ... Read user comments about the side effects, benefits, and effectiveness of cefamandole injection. ...
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Cefamandole (CAS 42540-40-9) Market Research Report 2018Cefamandole (CAS 42540-40-9) Market Research Report 2018

Market Research Report 2018 aims at providing comprehensive data on cefamandole market globally and regionally (Europe, ... Cefamandole prices in North America. 6.4. Cefamandole prices in other regions. 7. CEFAMANDOLE END-USE SECTOR 7.1. Cefamandole ... Cefamandole market forecast. 6. CEFAMANDOLE MARKET PRICES. 6.1. Cefamandole prices in Europe. 6.2. Cefamandole prices in Asia ... Cefamandole application spheres, downstream products. 3. CEFAMANDOLE MANUFACTURING METHODS. 4. CEFAMANDOLE PATENTS. Abstract. ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/cefamnole_42540-40-9_market_research_report.html

cefamandole sodium Global Market and Forecast Research : ReportsnReportscefamandole sodium Global Market and Forecast Research : ReportsnReports

65 Pages Report] Check for Discount on cefamandole sodium Global Market and Forecast Research report by ChemReport. ... The price of cefamandole sodium in 2016 Major end users of cefamandole sodium Potential users of cefamandole sodium The main ... cefamandole sodium Global Market and Forecast Research Table of Contents Part 1: General Information of cefamandole sodium ... 2.2 Construction of Industry Chain of cefamandole sodium Chapter 3: End User of cefamandole sodium List of Tables Manufacturers ...
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Cefamandole Sodium Salt | GoldBioCefamandole Sodium Salt | GoldBio

Cefamandole Sodium Salt is useful in studying antibiotic resistance and the effects of penicillin binding proteins. It is a ... Cefamandole sodium salt is freely soluble in aqueous solution.. Cephalosporins are a type of β-lactam antibiotic consisting of ... Cefamandole sodium salt is a second generation cephalosporin antibiotic. It is effective against a variety of gram-negative and ...
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Mandol / cefamandole nafate NDA 062560 international drug patent coverage, generic alternatives and suppliersMandol / cefamandole nafate NDA 062560 international drug patent coverage, generic alternatives and suppliers

The generic ingredient in MANDOL is cefamandole nafate. There are five drug master file entries for this compound. Additional ...
more infohttps://www.drugpatentwatch.com/p/NDA/062560

Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and...Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and...

WhileKlebsiella strains donated cefotaxime, cefamandole and cefuroxime resistance toEscherichia coli K-12 recipients, the ... Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and ...
more infohttps://link.springer.com/article/10.1007%2FBF01641355

Cefamandole sodium saltCefamandole sodium salt

Click to view prices and info for Cefamandole sodium salt o ... Buy and view Cefamandole sodium salt, for PBP 2A and otther PDP ... Cefamandole sodium salt is a second generation cephalosporin antibiotic.. TOKU-E offers two forms of cefamandole: cefamandole ... For a complete list of cefamandole MIC values, click here.. Media Supplements. Cefamandole can be used as a selective agent in ... cefamandole nafate is freely soluble and sparingly soluble in methanol. Cefamandole sodium is freely soluble in an aqueous ...
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Cefamandole Brand Name - PharmaCefamandole Brand Name - Pharma

Cefamandole Brand Name. Consequently What Comprise I Figured out? Hemorrhoids cefamandole brand name can materialize in just ... Why Makers cefamandole brand name Really should Commit Inside of Electronic Advertising and marketing When Contemporary York ... Mom & Daughters In fact, in cefamandole brand name excess of the remaining 10 yrs, Ive stored scraps of paper and e-mail ... Swedish Health-related Centre Transplant The AMA nevertheless delivers alone cefamandole brand name towards the general public ...
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Cefamandole (Mandol) | The Antimicrobial Index Knowledgebase - TOKU-ECefamandole (Mandol) | The Antimicrobial Index Knowledgebase - TOKU-E

The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. ... Cefamandole (Mandol) is a second-generation broad-spectrum cephalosporin antibiotic. ...
more infohttp://antibiotics.toku-e.com/antimicrobial_452.html

Wiekvoet: Cefamandole: PK after IV with six subjects in JAGSWiekvoet: Cefamandole: PK after IV with six subjects in JAGS

time=Cefamandole$Time,. conc=Cefamandole$conc,. n=nrow(Cefamandole),. subject =c(1:nlevels(Cefamandole$Subject))[Cefamandole$ ... png(Cefamandole.png). qplot(y=conc,x=Time,col=Subject,data=Cefamandole) +. scale_y_log10(cefamandole (mcg/ml))+. geom_line ... scale_y_log10(cefamandole (mcg/ml))+. geom_line(aes(y=conc,x=Time,col=Subject),alpha=1,data=Cefamandole)+. geom_ribbon(aes( ... scale_y_log10(cefamandole (mcg/ml))+. geom_line(aes(y=conc,x=Time,col=Subject),alpha=1,data=Cefamandole)+. geom_ribbon(aes( ...
more infohttp://wiekvoet.blogspot.be/2015/04/cefamandole-pk-after-iv-with-six.html

Second Generation Anti-anaerobe CephalosporinsSecond Generation Anti-anaerobe Cephalosporins

Cefamandole [Chemical/Ingredient], Cefamandole (product), Cefamandole (substance), cephamandole, CEFAMANDOLE. ... Ontology: Cefamandole. (C0007541) Definition (NCI) A second-generation cephalosporin antibiotic with bactericidal activity. ... Cefamandole, Cephamandole, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl- ... Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. It is also active ...
more infohttps://fpnotebook.com/ID/Pharm/ScndGnrtnAntAnrbCphlsprns.htm

September 1982 - Volume 25 - Issue 6 : Diseases of the Colon & RectumSeptember 1982 - Volume 25 - Issue 6 : Diseases of the Colon & Rectum

Cefamandole preparation for colonic surgery. Bogden, Paul E.; Pien, Francis D. Bogden, Paul E.; Pien, Francis D. Less ...
more infohttps://journals.lww.com/dcrjournal/toc/1982/25060

Cellulitis - RxMed.comCellulitis - RxMed.com

Mandol (Cefamandole). MANDOL® Lilly Cefamandole Nafate Antibiotic Action And Clinical Pharmacology: Cefamandole, a ...
more infohttps://www.rxmed.com/illnesses/cellulitis.html

Search | Britannica.comSearch | Britannica.com

Cefamandole (drug) Cefamandole: antibiotic: Cephalosporins: The second-generation cephalosporins (cefamandole, cefaclor, ... cefamandole, Mandol, infections of the respiratory and urinary tracts, skin, bone and joints, and blood; peritonitis. cefazolin ... Second-generation cephalosporins (e.g., cefuroxime and cefamandole) and third. -generation ones (such as ceftazidime) tend to ... Cefuroxime: cephalosporin: , cefuroxime and cefamandole) and third-generation ones (such as ceftazidime) tend to be more ...
more infohttps://www.britannica.com/search?query=cefamandole

Cefoperazone Advanced Patient Information - Drugs.comCefoperazone Advanced Patient Information - Drugs.com

For cefamandole. *For bacterial infections: *For injection dosage form: *Adults and teenagers-500 milligrams (mg) to 2 grams ... For patients receiving cefamandole, cefoperazone, or cefotetan by injection :. *Drinking alcoholic beverages or taking other ... Alcohol or alcohol-containing medicine (cefamandole, cefoperazone, and cefotetan only)-Using alcohol and these cephalosporins ... Bleeding problems, history of (cefamandole, cefditoren, cefoperazone, and cefotetan only)-These medicines may increase the ...
more infohttps://www.drugs.com/cons/cefoperazone.html

Warfarin (Oral Route) Proper Use - Mayo ClinicWarfarin (Oral Route) Proper Use - Mayo Clinic

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. Check with your doctor immediately if you have diarrhea, fever, or any symptoms of an infection. This medicine may cause skin necrosis or gangrene. Call your doctor right away if you have pain, a color change, or a temperature change to any area of your body. Call your doctor right away if you have pain in your toes and they look purple or dark in color. These could be signs of a serious medical problem. Calciphylaxis or calcium uremic arteriolopathy may occur in patients with or without end-stage kidney disease. Tell your doctor right away if you have purplish red, net-like, blotchy spots on the skin. This medicine may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your ...
more infohttps://www.mayoclinic.org/drugs-supplements/warfarin-oral-route/proper-use/DRG-20070945?p=1

Warfarin (Intravenous Route) Before Using - Mayo ClinicWarfarin (Intravenous Route) Before Using - Mayo Clinic

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
more infohttps://www.mayoclinic.org/drugs-supplements/warfarin-intravenous-route/before-using/drg-20071147

Neuroprotection with Beta-Lactam Compounds - Johns Hopkins UniversityNeuroprotection with Beta-Lactam Compounds - Johns Hopkins University

cefamandole. FK-037. benzathine penicillin. cefazolin. hetacillin. cefditoren. cloxacillin. cefepime. carbenicillin. cefetamet ...
more infohttp://www.freepatentsonline.com/y2007/0238717.html
  • Cefazolin Ceforanide http://www.toku-e.com/Assets/MIC/Cefamandole%20sodium%20salt.pdf Stork CM (2006). (wikipedia.org)
  • Escherichia coli: 0.12 - 400 μg/ml Haemophilus influenzae: 0.06 - >16 μg/ml Staphylococcus aureus: 0.1 - 12.5 μg/ml CO2 is generated during the normal constitution of cefamandole and ceftazidime, potentially resulting in an explosive-like reaction in syringes. (wikipedia.org)
  • The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms. (wikipedia.org)
  • Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained during a pilot study to investigate the pharmacokinetics of the drug cefamandole. (psu.edu)
  • Cefamandole (CAS 42540-40-9) Market Research Report 2018 aims at providing comprehensive data on cefamandole market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • The Cefamandole data is an IV data set with six subjects. (blogspot.be)
  • Plasma concentrations of the drug were measured on six healthy volunteers at 14 time points following an intraveneous dose of 15 mg/kg body weight of cefamandole. (psu.edu)
  • Hemorrhoids cefamandole brand name can materialize in just any age and it is very annoying and at instances confounding in the direction of track down a much better, natural and organic and effective process for piles. (schalmeienwelt.net)
  • Swedish Health-related Centre Transplant The AMA nevertheless delivers alone cefamandole brand name towards the general public and legislators as symbolizing Americas' medical doctors, even whilst symbolizing US physicians? (schalmeienwelt.net)
  • Why Makers cefamandole brand name Really should Commit Inside of Electronic Advertising and marketing When Contemporary York includes appreciated sustained wealth and plunging criminal offense charges mainly because the mid-1990s, Washington Heights contains remained fairly destructive and impoverished, and its general public universities are dismal. (schalmeienwelt.net)
  • It captures cefamandole market trends, pays close attention to cefamandole manufacturers and names suppliers. (marketpublishers.com)
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of cefamandole sodium. (reportsnreports.com)