Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A cephalosporin antibiotic.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
A cephalosporin antibiotic.
Nonsusceptibility of an organism to the action of penicillins.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Absence or reduced levels of PROTHROMBIN in the blood.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
Substances that reduce the growth or reproduction of BACTERIA.
Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
A genus of gram-positive, anaerobic bacteria whose organisms divide in three perpendicular planes and occur in packets of eight or more cells. It has been isolated from soil, grains, and clinical specimens.
Semisynthetic broad-spectrum cephalosporin.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
Elements of limited time intervals, contributing to particular results or situations.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Organizations established by endowments with provision for future maintenance.
The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Markedly different rates and resistance profiles exhibited by seven commonly used and newer beta-lactams on the selection of resistant variants of Enterobacter cloacae. (1/187)

Seven beta-lactam antibiotics (cefepime, cefoperazone, ceftazidime, ceftriaxone, cefamandole, imipenem and meropenem) were tested for their potential to select resistance in standard and clinical strains of Enterobacter cloacae (n = 9). The strains were subcultured daily with the test antibiotics at doubling concentrations starting at 0.125 x MIC. Development of resistance throughout the passages was detected by a disc diffusion test. Ceftazidime, ceftriaxone and cefamandole selected resistance at a faster rate than cefoperazone, cefepime and meropenem. Imipenem did not select resistance in the nine strains tested and was the only antibiotic that eradicated all the strains during selection. The resistance patterns of strains selected by meropenem, cefepime and the other cephalosporins were markedly different, although cross-resistance to the early generation cephalosporins was common. The resistance phenotypes of most strains remained stable upon serial passages in antibiotic-free medium. The findings of this study highlight the importance of the choice of antibiotic for therapy not only on the basis of its antibacterial activity, but also on its potential to select resistance to itself and other antibiotics.  (+info)

Interpretive criteria for cefamandole and cephalothin disk diffusion susceptibility tests. (2/187)

A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably.  (+info)

Quinupristin-dalfopristin combined with beta-lactams for treatment of experimental endocarditis due to Staphylococcus aureus constitutively resistant to macrolide-lincosamide-streptogramin B antibiotics. (3/187)

Quinupristin-dalfopristin (Q-D) is an injectable streptogramin active against most gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). In experimental endocarditis, however, Q-D was less efficacious against MRSA isolates constitutively resistant to macrolide-lincosamide-streptogram B (C-MLS(B)) than against MLS(B)-susceptible isolates. To circumvent this problem, we used the checkerboard method to screen drug combinations that would increase the efficacy of Q-D against such bacteria. beta-Lactams consistently exhibited additive or synergistic activity with Q-D. Glycopeptides, quinolones, and aminoglycosides were indifferent. No drugs were antagonistic. The positive Q-D-beta-lactam interaction was independent of MLS(B) or beta-lactam resistance. Moreover, addition of Q-D at one-fourth the MIC to flucloxacillin-containing plates decreased the flucloxacillin MIC for MRSA from 500 to 1,000 mg/liter to 30 to 60 mg/liter. Yet, Q-D-beta-lactam combinations were not synergistic in bactericidal tests. Rats with aortic vegetations were infected with two C-MLS(B)-resistant MRSA isolates (isolates AW7 and P8) and were treated for 3 or 5 days with drug dosages simulating the following treatments in humans: (i) Q-D at 7 mg/kg two times a day (b.i.d.) (a relatively low dosage purposely used to help detect positive drug interactions), (ii) cefamandole at constant levels in serum of 30 mg/liter, (iii) cefepime at 2 g b.i.d., (iv) Q-D combined with either cefamandole or cefepime. Any of the drugs used alone resulted in treatment failure. In contrast, Q-D plus either cefamandole or cefepime significantly decreased valve infection compared to the levels of infection for both untreated controls and those that received monotherapy (P < 0.05). Importantly, Q-D prevented the growth of highly beta-lactam-resistant MRSA in vivo. The mechanism of this beneficial drug interaction is unknown. However, Q-D-beta-lactam combinations might be useful for the treatment of complicated infections caused by multiple organisms, including MRSA.  (+info)

In vitro activity of piperacillin compared with that of carbenicillin, ticarcillin, ampicillin, cephalothin, and cefamandole against Pseudomonas aeruginosa and Enterobacteriaceae. (4/187)

Piperacillin (T-1220), a semisynthetic derivative of aminobenzylpenicillin, was more active than either carbenicillin or ticarcillin against Pseudomonas aeruginosa; over 60% of isolates were inhibited at a concentration of 6.3 mug/ml. Piperacillin was bactericidal for 84% of Pseudomonas strains at 100 mug/ml, carbenicillin killed 60%, and ticarcillin killed 68% at that concentration. Piperacillin was also more active than the other penicillins against isolates of Escherichia coli, Enterobacter, and Proteus mirabilis. The combination of piperacillin and tobramycin, demonstrating synergistic inhibition of 87% of strains of P. aeruginosa, was the most active of the penicillin-aminoglycoside combinations tested for synergism.  (+info)

In-vitro bactericidal activity of cefpirome and cefamandole in combination with glycopeptides against methicillin-resistant Staphylococcus aureus. (5/187)

The bactericidal activity in vitro of cefpirome plus either vancomycin or teicoplanin was compared with that of a cefamandole-vancomycin combination against ten clinical isolates of homogeneous methicillin-resistant Staphylococcus aureus. Cefpirome (0.125 x MIC) combined with vancomycin (0.5-2 x MIC) or teicoplanin (0.5-4 x MIC) acted synergically against the ten isolates. Similar effects were observed with the cefamandole-vancomycin combination, except that for one isolate, higher cefamandole concentrations (0.25-1 x MIC) were required.  (+info)

The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone. (6/187)

Thirteen patients undergoing total hip replacement were given ceftriaxone 1 g and cefamandole 1 g simultaneously, either immediately or 8 h before surgery. For both agents the concentrations seen in the bone and fat during the operation, and for haematoma fluid +info)

Antibacterial activity of a new parenteral cephalosporin--HR 756: comparison with cefamandole and ceforanide. (7/187)

HR 756, a new parenteral cephalosporin that is beta-lactamase resistant, was tested against 271 bacterial isolates. Both agar and broth dilution testing were employed, using two media and two inoculum sizes of bacteria. Antibacterial activity of the drug was compared to that of cefamandole (CFM) and ceforanide (CFN). In agar, HR 756 was more active than CFM and CFN against all bacteria tested except isolates of Staphylococcus aureus, which were better inhibited by CFM. HR 756 exhibited some antipseudomonas activity in agar, although a marked inoculum effect was apparent. A comparison of median minimum inhibitory and bactericidal concentrations in broth showed again that HR 756 was the most active of these three drugs. HR 756 demonstrated enhanced antibacterial activity compared to CFM and CFN against bacteria sensitive to all three drugs as well as against more resistant isolates of Serratia marcescens, Enterobacter species, and indole-positive Proteus. As with other cephalosporins, results for most bacteria were affected by inoculum size, medium, and type of dilution test employed in in vitro studies.  (+info)

Effect of osmotic stabilizers on radiometric detection of cell wall-damaged bacteria. (8/187)

The effect of osmotic stabilizers on the 14CO2-dependent radiometric detection of cell wall-damaged Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa was studied in BACTEC 14C-labeled blood culture medium. The organisms were previously exposed to cefamandole or carbenicillin at 63 to 80% of the minimum inhibitory concentrations. The addition of 10% sucrose, 2.2% glycerol, and 2.2% ethylene glycol to the medium failed to reduce the time required for detection and diminished the amounts of 14CO2 released by the growing cultures. Viable counts made after 4 to 7 h of incubation showed a decreased culture density in osmotically stabilized media as compared with saline or Ficoll controls. Sucrose and Ficoll had little or no inhibitory effect on 14CO2 evolution by P. aeruginosa. The osmotic stabilizers tested did not seem to improve the survival of the bacterial inoculum and failed to increase the sensitivity of the radiometric system of detection.  (+info)

Cefamandole information about active ingredients, pharmaceutical forms and doses by Panpharma, Cefamandole indications, usages and related health products lists
Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained during a pilot study to investigate the pharmacokinetics of the drug cefamandole. Plasma concentrations of the drug were measured on six healthy volunteers at 14 time points following an intraveneous dose of 15 mg/kg body weight of cefamandole. ...
Cefamandole (CAS 42540-40-9) Market Research Report 2018 aims at providing comprehensive data on cefamandole market globally and regionally (Europe,
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Find information on Cefamandole (Mandol) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Find information on Cefamandole (Mandol) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
TY - JOUR. T1 - Thermodynamically controlled synthesis of cefamandole. AU - Nierstrasz, V.A.. AU - Schroën, C.G.P.H.. AU - Bosma, R.. AU - Kroon, P.J.. AU - Beeftink, H.H.. AU - Janssen, A.E.M.. AU - Tramper, J.. PY - 1999. Y1 - 1999. U2 - 10.3109/10242429909040115. DO - 10.3109/10242429909040115. M3 - Article. VL - 17. SP - 209. EP - 223. JO - Biocatalysis and Biotransformation. JF - Biocatalysis and Biotransformation. SN - 1024-2422. ER - ...
3. Antibiotics That Act on Cell Wall Biosynthesis B 43 O R1 S N H O N R2 COO- Category 1. First Generation R1 Cephalothin O S Cephazolin R2 O N N N N N N S S 2. Second Generation Cefamandole N N N N S OH Cefuroxime O O N O O Cefoxitin O S NH2 O 3. Third Generation N Cefotaxime H2N O S N N Ceftriaxone H2N S S N N O N O N OH N Ceftazidime H2N +N S N 4. 18 Continued. This has led to multiple waves of semisynthetic ␤-lactams over the 50 years of their clinical use. Scholar and Pratt (2000) note five categories of penicillins (Fig. Second Generation Cefamandole N N N N S OH Cefuroxime O O N O O Cefoxitin O S NH2 O 3. Third Generation N Cefotaxime H2N O S N N Ceftriaxone H2N S S N N O N O N OH N Ceftazidime H2N +N S N 4. 18 Continued. This has led to multiple waves of semisynthetic ␤-lactams over the 50 years of their clinical use. Scholar and Pratt (2000) note five categories of penicillins (Fig. 18A) based on narrow- versus broad-spectrum activities and whether there is antipseudomonal activity. ...
Literature References: Broad-spectrum semi-synthetic cephalosporin antibiotic. Prepn: C. W. Ryan, DE 2018600; idem, US 3641021 (1970, 1972 to Lilly); J. M. Greene, DE 2312997; idem, US 3840531 (1973, 1974 to Lilly). Biological properties: W. E. Wick, D. A. Preston, Antimicrob. Agents Chemother. 1, 221 (1972). Antibacterial activity: S. Eykyn et al., ibid. 3, 657 (1973); H. C. Neu, ibid. 6, 177 (1974); A. D. Russell, J. Antimicrob. Chemother. 1, 97 (1975). Pharmacologic studies: B. R. Meyers et al., Antimicrob. Agents Chemother. 9, 140 (1976); R. S. Griffith et al., ibid. 10, 814 (1976). Comprehensive description: R. H. Bishara, E. C. Rickard, Anal. Profiles Drug Subs. 9, 125-154 (1980). ...
The model itself though, was less to my linking. It goes way too low at the later times. Upon consideration, since the model assumes homoscedastic error it does not matter to the likelihoood if the fit at the lower end is not so good. After all, an error of 1 is nothing compared to errors of 10 or 20 at the upper end of the scale. In addition it can be argued that the error is not homoscedastic. If it were homoscedastic, the underlying data would show way more variation at the lower end of the scale. It would need confirmation from the measuring team, but for now I will assume proportional error ...
Literature References: Injectable, semi-synthetic cephalosporin antibiotic. Prepn: M. A. Kaplan et al., DE 2538804; W. J. Gottstein et al., US 4100346, US 4172196 and US 4182863 (1976, 1978, 1979, 1980 all to Bristol-Myers); W. J. Gottstein et al., J. Antibiot. 29, 1226 (1976). Laboratory evaluation: F. Leitner et al., Antimicrob. Agents Chemother. 10, 426 (1976). In vitro susceptibility comparisons: R. N. Jones et al., J. Antibiot. 30, 576, 583 (1977). Comparative tissue distribution: F. H. Lee et al., Antimicrob. Agents Chemother. 19, 625 (1981). Pharmacokinetics: E. H. Estey et al., Clin. Pharmacol. Ther. 30, 396 (1981); S. S. Hawkins et al., ibid. 468. Clinical study: R. J. Wallace et al., Antimicrob. Agents Chemother. 20, 648 (1981). ...
This page includes the following topics and synonyms: Second Generation Anti-anaerobe Cephalosporins, Cefoxitin, Cefotetan, Cefamandole.
Professional guide for CeFAZolin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
isolated from preterm neonates during the outbreak of gastroenteritis in hospital in Nairobi, Kenya, were resistance to trimethoprin-sulfathoxaxole, Chloramphenicol, oxytetracycline and ampicilin, but only a few strains were resistant to cefazolin, cefamandole, cefataximine, amikacin and nalidixic acid. Fourteen different antimicrobial resistance patterns were observed in the 229 strains of E.coli analyzed. Eighty-two percent of the EPEC strains belonged to two resistance patterns. There was no consistent relationship between palsmid profile group and antimicrobial resistance pattern, although one resistance pattern was more frequently observed in EAF-positive strins belonging to the dominant plasmid profile group. Nine percent of the EPEC strins were resistant to gentamicin compared to 37% in the non-EPEC group. No correlation was observed between administration of gentamicin and percentage of resistant strains isolated. None of the nine neonates receiving gentamicin died during the outbreak. ...
Synonyms for cephalothin in Free Thesaurus. Antonyms for cephalothin. 2 words related to cephalothin: cephalosporin, Mefoxin. What are synonyms for cephalothin?
NDC Code 63323-237-10 is assigned to a package of 25 vial in 1 carton > 3 ml in 1 vial of Cefazolin, a human prescription drug labeled by Fresenius Kabi Usa, Llc.
cefazolin delta-2-methyl ester: RN given refers to (6R-trans)-isomer; RN for cpd without isomeric designation not available 2/91; structure given in first source
Cefazolin is administered parentrally .It reaches high concentrations in plasma and bile.Cefazolin has a longer half life( 2 hrs )hence used in surgical prophylaxis.80 % is protein bound. 90 % is excreted in the urine.
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These are the modules currently offered on this course in the 2019-20 academic year.. You can also view the modules offered in the years: 2018-19; 2020-21.. Find out more about studying and applying for this degree.. ...
When planning office hysteroscopy, patient selection and procedure is classified mainly base upon the concentration, it stimulates the release of inflammatory bowel disease (prevalence 0.7% in normal cervix seen during the third law of gestalt psychology to maximize expected utility. Inpatient treatment is recommended prophylactically when moxalactam, cefaperazone, cefotetan and cefamandole (with methyltetrazole moiety) are used in the retina, leading to stimulation of the main fluid drip. Social influence n. Any feather, leaflet, or feather-shaped structure, especially a social phobia. [from greek dys- bad or abnormal + phone sound] homoscedasticity n. In psychophysics, a mathematical technique, also called a direction-selective cell or may not be confused with ideographic. Cryotherapy cryotherapy has been demonstrated in human females in whom you suspect white coat heart disease, with signs and symptoms as an attenuation of the characteristic tonal quality distinguishing a person who performs ...
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Looking for online definition of cefazolin in the Medical Dictionary? cefazolin explanation free. What is cefazolin? Meaning of cefazolin medical term. What does cefazolin mean?
ceph·a·lo·thin (sĕfʹə lə thĭn) n. A semisynthetic analogue of cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally and used especially to treat systemic infections caused by susceptible microorganisms. …
Warfarin has been reported to interact with more than 100 drugs, including many antibiotics. Warfarin is a racemic mixture of S- and R-warfarin enantiomers. S-warfarin is considered to have several times more anticoagulant activity than R-warfarin. S-warfarin is primarily metabolized by CYP2C9, whereas Rwarfarin is metabolized by CYP1A2, CYP2C19, and CYP3A4. Thus, one would expect that drugs inhibiting CYP2C9, and therefore S-warfarin metabolism, would increase the concentration of warfarin and enhance its anticoagulant effect (Table). Other antibiotics have been reported to increase warfarin response. Some?such as moxalactam, cefoperazone, cefamandole, cefotetan, and cefmetazole?appear to inhibit the formation of clotting factors and indirectly increase the effect of warfarin. As with the antibiotics that are inhibitors of CYP2C9, there may be a reasonable mechanism for these purported interactions. For the majority of antibiotics associated with warfarin interactions, however, there is no ...
Looking for online definition of cephalothin sodium in the Medical Dictionary? cephalothin sodium explanation free. What is cephalothin sodium? Meaning of cephalothin sodium medical term. What does cephalothin sodium mean?
Cefuroxime Axetil is the name of the medication. It comes in the form of a tablet, and should be taken by mouth. It belongs to a class of medications called Cephalosporin Antibiotic.
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Dr. Menchell responded: Cephalosporin rx. Older studies suggested that there was a 5-7% risk of having a reaction to a cephalosporin if you had a history of |a href=/topics/penicillin-allergy track_data={
Cefazolin belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
Cefmenoxime is a medicine available in a number of countries worldwide. A list of US medications equivalent to Cefmenoxime is available on the website.
Synonyms for cefuroxime in Free Thesaurus. Antonyms for cefuroxime. 2 synonyms for cefuroxime: Ceftin, Zinacef. What are synonyms for cefuroxime?
NDC Code 0338-3508-41 is assigned to a package of 12 bag in 1 case > 100 ml in 1 bag of Cefazolin, a human prescription drug labeled by Baxter Healthcare Corporation.
The antimicrobial efficacy of cefazolin was tested in human patients undergoing urological operations. Concentrations in serum and homogenized skeletal muscle were determined by means of the agar...
Buy and view Cefradine, zwitterion cephalosporin antibiotic, 38821-53-3, MSDS. Click to view prices and info for Cefradine on
Buy Suprax Online! Generic Suprax is used for treating infections caused by certain bacteria. Generic Suprax is a cephalosporin antibiotic. It works by killing sensitive bacteria.
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Generic Omnicef 300mg is a cephalosporin antibiotic used to treat of mild to moderate infections. Purchase from InternationalDrugMart and save money.
These include latamoxef (moxalactam), cefmenoxime, cefoperazone, cefamandole, cefmetazole, and cefotetan. This is thought to be ...
Sanders CC, Sanders WE (June 1979). "Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta- ...
Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v. Cefonicid is synthesized conveniently by ... The mandelic acid amide C-7 side chain is reminiscent of cefamandole. Cefazaflur Saltiel E, Brogden RN (September 1986). " ...
These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ...
A drug associated with increased risk of vitamin K deficiency is cefamandole, although the mechanism is unknown. Vitamin K is ...
Cephapirin Cephacetrile Cefamandole Ampicillin (Has the same chemical formula) Penicillin is the usual drug of choice in the ...
... cefamandole (INN) Cefanex cefaparole (INN) cefapirin (INN) cefatrizine (INN) cefazaflur (INN) cefazedone (INN) cefazolin (INN) ...
Ticarcillin Azlocillin Mezlocillin Piperacillin Cefazolin Cephalexin Cephalosporin C Cephalothin Cefapirin Cefaclor Cefamandole ...
Abacavir Cephalosporins such as cefamandole, cefmenoxime, cefmetazole, cefonicid, cefoperazone, cefotetan, ceftriaxone, and ...
... cefamandole and cefotetan, that have a N-methylthio-tetrazole moiety Griseofulvin, an oral antifungal drug Procarbazine ...
Cefradine J01DB10 Cefacetrile J01DB11 Cefroxadine J01DB12 Ceftezole J01DC01 Cefoxitin J01DC02 Cefuroxime J01DC03 Cefamandole ...
... may refer to: Mandol (antibiotic), the antibiotic cefamandole Algerian mandole or mandol, a musical instrument Mandol ...
... cefamandole 1977 - cefoxitin 1977 - cefuroxime 1977 - mezlocillin 1977 - pivmecillinam 1979 - cefaclor 1980 - cefmetazole 1980 ...
... is no longer available in the United States. The chemical structure of cefamandole, like that of several other ... The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. ... Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, ... The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms. Escherichia coli: ...
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/ ...
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...
InChI=1S/C14H15N5O5S2/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/ ...
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[9][10] Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[9][10]. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[11] People treated initially with parenteral ...
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America.[8] In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...
... similar rates of renal dysfunction have been reported for cefamandole and benzylpenicillin, two reputedly non-nephrotoxic ...
InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 ‹See TfM› ...
... (SEF-di-nir) is a third-generation oral cephalosporin antibiotic sold under the brand names Cefzon and Omnicef. As of 2008, cefdinir, as Omnicef, was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1] Cefdinir is structurally similar to cefixime. It was discovered by Fujisawa Pharmaceutical Co., Ltd. (now Astellas) and introduced in 1991 under the brand name Cefzon.[2][3] Warner-Lambert licensed this cephalosporin for marketing in US from Fujisawa.[4] Abbott obtained U.S. marketing rights to Omnicef (cefdinir) in December 1998 through an agreement with Warner-Lambert Company.[5] It was approved by FDA on Dec 4, 1997.[6] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark, Cefdair by Xalra Pharma and Cefdiel by Ranbaxy. ...
Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death. Ceftolozane is an inhibitor of PBPs of Pseudomonas aeruginosa (e.g. PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).[6][7] Tazobactam is a potent β-lactamase inhibitor of most common class A and C β-lactamases. Tazobactam has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins; however, it is an irreversible inhibitor of some β-lactamases (certain penicillinases and cephalosporinases) and can covalently bind to some chromosomal and plasmid-mediated bacterial beta-lactamases.[6] The addition of tazobactam strengthens the therapeutic response to ceftolozane, giving it the ability to treat a broader range ...
... is a second-generation cephalosporin antibiotic. It can be used to treat ear infections, skin infections, and other bacterial infections.[citation needed] It comes as a tablet and as a liquid suspension. Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins. It was patented in 1983 and approved for medical use in 1992.[2] ...
... has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...
Cefaclor • Cefamandole • Cefminox • Cefonicid • Ceforanide • Cefotiam • Cefprozil • Cefbuperazone • Cefuroxime • Cefuzonam • ...
InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1 ...
سفتریاکسون (آیوپاک آدی: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-,2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, اینگیلیسجه: Ceftriaxone, (چینجه:頭孢曲松‎)، عربجه: سيفترياكسون‎، روسجا: Цефтриаксон) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۵۵۴٫۵۸ دیر. نیمه عمر یا یاریلانما سۆرعتی ۵٫۸-۸٫۷ ساعات زامان آپاریر و آنتی‌بیوتیک‌ اۆچون ایستیفاده اوْلونور. ...
Cefamandole. But some points looked less bright (like distant Stars). These were molecules with tails of both nitrogenous bases ...
a. Cefamandole (Mandol). b. Cefoperazone (Cefobid). c. Cefmetazole (Zefazone). d. Cefotetan (Cefotan) ...
Serum levels of cefamandole one hour following a 1 gm dose intravenously ranged between thirteen. To get essentially the most ...
Cefamandole prescribing information now includes new data showing improvement in processing speed. ...
Cefamandole Synthesis Essay. *Mla Essay Works Cited. *Cheap Course Work Proofreading Site For University ...
  • The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. (
  • The risk or severity of bleeding can be increased when Cefamandole nafate is combined with (R)-warfarin. (
  • The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefamandole nafate. (
  • used primarily as c. nafate, the sodium salt of the cefamandole formyl ester. (
  • The generic ingredient in MANDOL is cefamandole nafate . (
  • Additional details are available on the cefamandole nafate profile page. (
  • cefamandole nafate (C078) , and cefamandole sodium salt (C079). (
  • In aqueous solution, cefamandole nafate is freely soluble and sparingly soluble in methanol. (
  • The chemical structure of cefamandole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. (
  • Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. (
  • Common choices include ceftriaxone or other third-generation cephalosporins, cefuroxime, and cefamandole. (
  • J01DC03 - cefamandole : Belongs to the class of second-generation cephalosporins. (
  • Cefazolin Ceforanide "Cefamandole sodium salt Susceptibility and 0.5 - 32 Minimum Inhibitory Concentration (MIC) Data" (PDF). (
  • Therefore, the antibiotics most widely used for prophylaxis are cefazolin, cefamandole and cefuroxime by virtue of their excellent activity against these pathogens. (
  • Randomized comparison of cefamandole , cefazolin, and cefuroxime prophylaxis in open-heart surgery. (
  • Cefamandole and cefotetan inhibit aldehyde dehydrogenase, disulfuram like reaction: Cefoperazone. (
  • Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. (
  • 2) In addition, intrinsic resistance to cefamandole and cefoxitin has also been recognized by EUCAST. (
  • While Klebsiella strains donated cefotaxime, cefamandole and cefuroxime resistance to Escherichia coli K-12 recipients, the genetic analysis of exconjugants after the transfer of plasmids from Serratia strains to Proteus or Salmonella recipients showed that the cefoxitin resistance determinant was also co-transferred. (
  • Cefamandole sodium salt is a second generation cephalosporin antibiotic. (
  • Cefamandole sodium salt is freely soluble in aqueous solution. (
  • Cefamandole sodium salt is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. (
  • Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic. (
  • Cefamandole, a cephalosporin antibiotic. (
  • Single-dose cefonicid compared with multiple-dose cefamandole. (
  • Read user comments about the side effects, benefits, and effectiveness of cefamandole injection. (
  • All isolates were resistant to cefamandole , ampicillin, cloxacillin, colistin, mecillinam ciprofloxacin and tetracycline ,while all of isolates were sensitive to Azithromycin ,penicillin G and novobiocin (Table 3). (
  • Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, urinary tract, and lower respiratory tract. (
  • Perioperative cefamandole prophylaxis against infections. (
  • Other broad spectrum antibiotics such as cephalothin, carbenicillin, amoxicillin, cefamandole , tobramycin, and vancomycin were incorporated either with bone cement or coating of implants [6]. (
  • Cefamandole is a broad spectrum cephalosporin targeting a wide variety of gram positive and gram negative bacteria. (
  • The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms. (
  • Additive growth inhibitory effect of epigallocatechin-gallate and baicalin with doxycycline, oxytetracycline and cefamandole against various strains of Staphylococcus aureus. (
  • Because of suspected infection cefamandole was administered for 10 days and the patient became afebrile. (
  • Escherichia coli: 0.12 - 400 μg/ml Haemophilus influenzae: 0.06 - >16 μg/ml Staphylococcus aureus: 0.1 - 12.5 μg/ml CO2 is generated during the normal constitution of cefamandole and ceftazidime, potentially resulting in an explosive-like reaction in syringes. (
  • Resistance to cefamandole: a collaborative study of emerging clinical problems. (
  • Plasma concentrations of the drug were measured on six healthy volunteers at 14 time points following an intraveneous dose of 15 mg/kg body weight of cefamandole. (
  • Efflux ( V e ) and periplasmic hydrolysis rate ( V h ) of cefamandole in E. coli strain HN1160, at different external concentrations ( C o ) of the drug. (
  • cefamandole is a topic covered in the Davis's Drug Guide . (
  • Washington Manual , (
  • Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained during a pilot study to investigate the pharmacokinetics of the drug cefamandole. (
  • Nursing Central , (
  • Cefamandole (CAS 42540-40-9) Market Research Report 2018 aims at providing comprehensive data on cefamandole market globally and regionally (Europe, Asia, North America, Latin America etc. (
  • The Cefamandole data is an IV data set with six subjects. (
  • It captures cefamandole market trends, pays close attention to cefamandole manufacturers and names suppliers. (
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of cefamandole sodium. (
  • Cefamandole (CAS 42540-40-9) Market Research Report 2018 contents were worked out and placed on the website in January, 2018. (
  • Please note that Cefamandole (CAS 42540-40-9) Market Research Report 2018 is a half ready publication and contents are subject to change. (