An enzyme that catalyzes the formation of PHOSPHATIDYLINOSITOL and CMP from CDP-DIACYLGLYCEROL and MYOINOSITOL.
A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
The ester of diacylglycerol with the terminal phosphate of cytidine diphosphate. It serves as an intermediate in the biosynthesis of phosphatidylethanolamine and phosphatidylserine in bacteria.
An enzyme that catalyzes the formation of phosphatidylserine and CMP from CDPdiglyceride plus serine. EC 2.7.8.8.
An enzyme of the transferase class that uses ATP to catalyze the phosphorylation of diacylglycerol to a phosphatidate. EC 2.7.1.107.
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
Diglycerides are a type of glyceride, specifically a form of lipid, that contains two fatty acid chains linked to a glycerol molecule by ester bonds.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglycerol is covalently joined to LONG-CHAIN ACYL COA to form triglyceride. It was formerly categorized as EC 2.3.1.124.
Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
GLYCEROL esterified with FATTY ACIDS.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.
'Sugar phosphates' are organic compounds that consist of a sugar molecule linked to one or more phosphate groups, playing crucial roles in biochemical processes such as energy transfer and nucleic acid metabolism.
Fatty acid derivatives of glycerophosphates. They are composed of glycerol bound in ester linkage with 1 mole of phosphoric acid at the terminal 3-hydroxyl group and with 2 moles of fatty acids at the other two hydroxyl groups.
A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.

Identification of AtPIS, a phosphatidylinositol synthase from Arabidopsis. (1/56)

Phosphatidylinositol synthase is the enzyme responsible for the synthesis of phosphatidylinositol, a key phospholipid component of all eukaryotic membranes and the precursor of messenger molecules involved in signal transduction pathways for calcium-dependent responses in the cell. Using the amino acid sequence of the yeast enzyme as a probe, we identified an Arabidopsis expressed sequence tag potentially encoding the plant enzyme. Sequencing the entire cDNA confirmed the homology between the two proteins. Functional assays, performed by overexpression of the plant cDNA in Escherichia coli, a bacteria which lacks phosphatidylinositol and phosphatidylinositol synthase activity, showed that the plant protein induced the accumulation of phosphatidylinositol in the bacterial cells. Analysis of the enzymatic activity in vitro showed that synthesis of phosphatidylinositol occurs when CDP-diacylglycerol and myo-inositol only are provided as substrates, that it requires manganese or magnesium ions for activity, and that it is at least in part located to the bacterial membrane fraction. These data allowed us to conclude that the Arabidopsis cDNA codes for a phosphatidylinositol synthase. A single AtPIS genetic locus was found, which we mapped to Arabidopsis chromosome 1.  (+info)

Phosphatidylinositol is an essential phospholipid of mycobacteria. (2/56)

Phosphatidylinositol (PI) and metabolically derived products such as the phosphatidylinositol mannosides and linear and mature branched lipomannan and lipoarabinomannan are prominent phospholipids/lipoglycans of Mycobacterium sp. believed to play important roles in the structure and physiology of the bacterium as well as during host infection. To determine if PI is an essential phospholipid of mycobacteria, we identified the pgsA gene of Mycobacterium tuberculosis encoding the phosphatidylinositol synthase enzyme and constructed a pgsA conditional mutant of Mycobacterium smegmatis. The ability of this mutant to synthesize phosphatidylinositol synthase and subsequently PI was dependent on the presence of a functional copy of the pgsA gene carried on a thermosensitive plasmid. The mutant grew like the control strain under permissive conditions (30 degrees C), but ceased growing when placed at 42 degrees C, a temperature at which the rescue plasmid is lost. Loss of cell viability at 42 degrees C was observed when PI and phosphatidylinositol dimannoside contents dropped to approximately 30 and 50% of the wild-type levels, respectively. This work provides the first evidence of the essentiality of PI to the survival of mycobacteria. PI synthase is thus an essential enzyme of Mycobacterium that shows promise as a drug target for anti-tuberculosis therapy.  (+info)

Molecular cloning, functional complementation in Saccharomyces cerevisiae and enzymatic properties of phosphatidylinositol synthase from the protozoan parasite Toxoplasma gondii. (3/56)

The obligate intracellular parasite Toxoplasma gondii, the causative agent of toxoplasmosis, switches between the rapidly dividing tachyzoite and the slowly replicating bradyzoite in intermediate hosts such as humans and domestic animals. We have recently identified a bradyzoite cDNA encoding a putative phosphatidylinositol (PtdIns) synthase using a subtractive library [Yahiaoui, B., Dzierszinski, F., Bernigaud, A., Slomianny, C., Camus, D., and Tomavo, S. (1999) Mol. Biochem. Parasitol. 99, 223-235]. Here, we report the cloning of another cDNA encoding PtdIns synthase that is exclusively expressed in the tachyzoite stage. The two transcripts are encoded by two different genes, which are stage-specifically regulated. The deduced amino-acid sequence (258 amino acids with a calculated total molecular mass of 27.8 kDa) of the tachyzoite-specific cDNA shares a significant degree of identity (between 26.5 and 30.1%) to the PtdIns synthases from human, rat, Arabidopsis thaliana and yeast. Interestingly, the putative protein encompasses an N-terminal extension that is approximately 40 amino-acids longer than that of PtdIns synthases from other organisms. Functional complementation realized by tetrad analysis of segregants of a Saccharomyces cerevisiae PtdIns synthase-deficient mutant (PIS1/pis1:kanMX4) showed that only the T. gondii putative PtdIns synthase truncated at its N-terminal extension is able to restore the viability of the cells. We demonstrate that this protein expressed in yeast transformants is functionally active in the membrane preparation and requires manganese and magnesium ions for activity. To our knowledge, this is the first report on the molecular cloning and functional analysis of a gene encoding a PtdIns synthase in protozoan parasites.  (+info)

Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis. (4/56)

In order to study some of its enzymatic properties, phosphatidylinositol synthase 1 (AtPIS1) from the plant Arabidopsis thaliana was expressed in Escherichia coli, a host naturally devoid of phosphatidylinositol (PtdIns). In the context of the bacterial membrane and in addition to de novo synthesis, the plant enzyme is capable of catalysing the exchange of the inositol polar head for another inositol. Our data clearly show that the CDP-diacylglycerol-independent exchange reaction can occur using endogenous PtdIns molecular species or PtdIns molecular species from soybean added exogenously. Exchange has been observed in the absence of cytidine monophosphate (CMP), but is greatly enhanced in the presence of 4 microm CMP. Our data also show that AtPIS1 catalyses the removal of the polar head in the presence of much higher concentrations of CMP, in a manner that suggests a reverse of synthesis. All of the PtdIns metabolizing activities require free manganese ions. EDTA, in the presence of low Mn2+ concentrations, also has an enhancing effect.  (+info)

Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe. (5/56)

CDP-diacylglycerol (CDP-DG) is an important branchpoint intermediate in eucaryotic phospholipid biosynthesis and could be a key regulatory site in phospholipid metabolism. Therefore, we examined the effects of growth phase, phospholipid precursors, and the disruption of phosphatidylcholine (PC) synthesis on the membrane-associated phospholipid biosynthetic enzymes CDP-DG synthase, phosphatidylglycerolphosphate (PGP) synthase, phosphatidylinositol (PI) synthase, and phosphatidylserine (PS) synthase in cell extracts of the fission yeast Schizosaccharomyces pombe. In complete synthetic medium containing inositol, maximal expression of CDP-DG synthase, PGP synthase, PI synthase, and PS synthase in wild-type cells occurred in the exponential phase of growth and decreased two- to fourfold in the stationary phase of growth. In cells starved for inositol, this decrease in PGP synthase, PI synthase, and PS synthase expression was not observed. Starvation for inositol resulted in a twofold derepression of PGP synthase and PS synthase expression, while PI synthase expression decreased initially and then remained constant. Upon the addition of inositol to inositol-starved cells, there was a rapid and continued increase in PI synthase expression. We examined expression of these enzymes in cho2 and cho1 mutants, which are blocked in the methylation pathway for synthesis of PC. Choline starvation resulted in a decrease in PS synthase and CDP-DG synthase expression in cho1 but not cho2 cells. Expression of PGP synthase and PI synthase was not affected by choline starvation. Inositol starvation resulted in a 1.7-fold derepression of PGP synthase expression in cho2 but not cho1 cells when PC was synthesized. PS synthase expression was not depressed, while CDP-DG synthase and PI synthase expression decreased in cho2 and cho1 cells in the absence of inositol. These results demonstrate that (i) CDP-DG synthase, PGP synthase, PI synthase, and PS synthase are similarly regulated by growth phase; (ii) inositol affects the expression of PGP synthase, PI synthase, and PS synthase; (iii) disruption of the methylation pathway results in aberrant patterns of regulation of growth phase and phospholipid precursors. Important differences between S. pombe and Saccharomyces cerevisiae with regard to regulation of these enzymes are discussed.  (+info)

Inhibition of CDP-DG: inositol transferase by inostamycin. (6/56)

Inostamycin, a novel microbial secondary metabolite, inhibited [3H]inositol and 32P1 incorporation into phosphatidylinositol (PtdIns) induced by epidermal growth factor (EGF) in cultured A431 cells, the IC50 being 0.5 micrograms/ml, without inhibiting macromolecular synthesis. The drug inhibited cellular inositol phosphate formation only when it was added at the same time as labeled inositol. It was found to inhibit in vitro CDP-DG:inositol transferase activity of the A431 cell membrane, the IC50 being about 0.02 micrograms/ml. It did not inhibit tyrosine kinase, PtdIns phospholipase C, or PtdIns kinase. Therefore, inhibition of PtdIns turnover by inostamycin must be due to the inhibition of CDP-DG:inositol transferase. Thus, inostamycin is a novel inhibitor of CDP-DG:inositol transferase.  (+info)

Evidence of a role for phosphatidylinositol synthesis in human amnion cell proliferation. (7/56)

Phosphatidylinositol (PtdIns) is the key precursor of phosphoinositide-derived intracellular mediators. The effects of changing the rate of PtdIns synthesis on mitogenic activity of human amnion-derived WISH cells were investigated. Incubation of the cells with [3H]inositol caused a time- and dose-dependent PtdIns labeling. Exogenous Ca2+ inhibited [3H]inositol incorporation in a dose-dependent fashion; half-maximal inhibition occurred with 0.3-1.0 mM Ca2+. In contrast, removal of cytosolic Ca2+ by ionophore A23187 and 1 mM EGTA induced enhancement of the PtdIns labeling as a function of A23187 concentration, perhaps through release of inhibitory effects of endogenous Ca2+. The A23187-stimulated PtdIns labeling with [3H]inositol was not abolished by additional unlabeled inositol, suggesting that [3H]inositol labeling of PtdIns occurred mainly through de novo synthesis catalyzed by PtdIns synthase (EC 2.7.8.11). In cells with PtdIns synthase activity decreased by exogenous Ca2+, [3H]thymidine incorporation was also inhibited, while A23187 caused dose-dependent enhancement of thymidine incorporation. The changes in PtdIns synthase activity occurred in parallel with changes in mitogenic activity caused by increasing the dose of exogenous Ca2+ or A23187. A similar lowering of mitogenic activity was observed upon suppression of PtdIns synthase by pemirolast potassium (9-methyl-3-1H-tetrazol-5yl-4H-pyrido[1,2-a]pyridin-4-one potassium) via a Ca(2+)-independent mechanism. These data demonstrate that changes in PtdIns synthase activity by some agents acting via different mechanisms are associated with parallel changes in thymidine incorporation, and suggest that PtdIns production is tightly coupled to cell proliferation in human amnion cells.  (+info)

Synthetic capacity of Arabidopsis phosphatidylinositol synthase 1 expressed in Escherichia coli. (8/56)

Phosphatidylinositol (PtdIns) synthase 1 from the plant Arabidopsis thaliana has been expressed in Escherichia coli in order to study the synthetic capacities of the enzyme. Analysis of the total fatty acid content of the bacteria shows that PtdIns synthase activity does not have a profound effect on the proportions of the different fatty acids produced, even if the presence of an extra acidic phospholipid leads to a global reduction of the lipid content. A closer analysis carried out on individual phospholipids reveals a global fatty acid composition almost unchanged in the two major bacterial lipids phosphatidylethanolamine (PtdEtn) and phosphatidylglycerol (PtdGro). Phosphatidylinositol has a very unusual composition that shows the ability of the plant enzyme to use CDP-diacylglycerol molecular species absent from plants. We identified the various PtdIns molecular species. They represent a pool of the major molecular species of PtdEtn and PtdGro. These results, together with the determination of the apparent affinity constants of AtPIS1 for myo-inositol and CDP-diacylglycerol, allow us to discuss some of the constraints of PtdIns synthesis in plants in terms of specificity, which will depend on the subcellular localization of the protein.  (+info)

CDP-diacylglycerol-inositol 3-phosphatidyltransferase is an enzyme that plays a role in the synthesis of phosphatidylinositol (PI) lipids, which are important components of cell membranes and also serve as secondary messengers in intracellular signaling pathways.

The enzyme catalyzes the transfer of a phosphate group from CDP-diacylglycerol to the 3-hydroxyl position of inositol, resulting in the formation of phosphatidylinositol 3-phosphate (PI3P). PI3P is a key signaling molecule that regulates various cellular processes, including membrane trafficking, autophagy, and inflammation.

CDP-diacylglycerol-inositol 3-phosphatidyltransferase is also known as phosphatidylinositol 3-kinase (PI3K) or type II PI3K, and it is distinct from the class I PI3Ks that are involved in growth factor signaling and oncogenesis. Mutations in CDP-diacylglycerol-inositol 3-phosphatidyltransferase have been implicated in various diseases, including cancer, neurodevelopmental disorders, and autoimmune diseases.

Phosphotransferases are a group of enzymes that catalyze the transfer of a phosphate group from a donor molecule to an acceptor molecule. This reaction is essential for various cellular processes, including energy metabolism, signal transduction, and biosynthesis.

The systematic name for this group of enzymes is phosphotransferase, which is derived from the general reaction they catalyze: D-donor + A-acceptor = D-donor minus phosphate + A-phosphate. The donor molecule can be a variety of compounds, such as ATP or a phosphorylated protein, while the acceptor molecule is typically a compound that becomes phosphorylated during the reaction.

Phosphotransferases are classified into several subgroups based on the type of donor and acceptor molecules they act upon. For example, kinases are a subgroup of phosphotransferases that transfer a phosphate group from ATP to a protein or other organic compound. Phosphatases, another subgroup, remove phosphate groups from molecules by transferring them to water.

Overall, phosphotransferases play a critical role in regulating many cellular functions and are important targets for drug development in various diseases, including cancer and neurological disorders.

Cytidine diphosphate-diacylglycerol (CDP-DAG) is a bioactive lipid molecule that plays a crucial role in the synthesis of other lipids and is also involved in cell signaling pathways. It is formed from the reaction between cytidine diphosphocholine (CDP-choline) and phosphatidic acid, catalyzed by the enzyme CDP-choline:1,2-diacylglycerol cholinephosphotransferase.

CDP-DAG is a critical intermediate in the biosynthesis of several important lipids, including phosphatidylglycerol (PG), cardiolipin (CL), and platelet-activating factor (PAF). These lipids are essential components of cell membranes and have various functions in cell signaling, energy metabolism, and other physiological processes.

CDP-DAG also acts as a second messenger in intracellular signaling pathways, particularly those involved in the regulation of gene expression, cell proliferation, differentiation, and survival. It activates several protein kinases, including protein kinase C (PKC) isoforms, which phosphorylate and regulate various target proteins, leading to changes in their activity and function.

Abnormalities in CDP-DAG metabolism have been implicated in several diseases, including cancer, cardiovascular disease, and neurological disorders. Therefore, understanding the regulation and function of CDP-DAG and its downstream signaling pathways is an active area of research with potential therapeutic implications.

CDP-diacylglycerol-serine O-phosphatidyltransferase is an enzyme that plays a role in the synthesis of phosphatidylserine, a type of phospholipid found in cell membranes. The systematic name for this enzyme is CDP-diacylglycerol:L-serine O-phosphatidyltransferase. It catalyzes the following chemical reaction:

CDP-diacylglycerol + L-serine = CMP + O-phosphatidylserine

This enzyme is involved in the Kennedy pathway, which is the main pathway for the biosynthesis of glycerophospholipids in eukaryotic cells. CDP-diacylglycerol-serine O-phosphatidyltransferase is located in the endoplasmic reticulum and is essential for the synthesis of phosphatidylserine, which is an important structural component of cell membranes and also serves as a precursor for the biosynthesis of other phospholipids. Defects in this enzyme have been associated with neurological disorders.

Diacylglycerol kinase (DGK) is an enzyme that plays a role in regulating cell signaling pathways. It catalyzes the conversion of diacylglycerol (DAG), a lipid second messenger, to phosphatidic acid (PA). This reaction helps to terminate DAG-mediated signals and initiate PA-mediated signals, which are involved in various cellular processes such as proliferation, differentiation, and survival. There are several isoforms of DGK that differ in their regulation, subcellular localization, and substrate specificity. Inhibition or genetic deletion of DGK has been shown to affect a variety of physiological and pathological processes, including inflammation, immunity, cancer, and neurological disorders.

Inositol is not considered a true "vitamin" because it can be created by the body from glucose. However, it is an important nutrient and is sometimes referred to as vitamin B8. It is a type of sugar alcohol that is found in both animals and plants. Inositol is involved in various biological processes, including:

1. Signal transduction: Inositol phospholipids are key components of cell membranes and play a crucial role in intracellular signaling pathways. They act as secondary messengers in response to hormones, neurotransmitters, and growth factors.
2. Insulin sensitivity: Inositol and its derivatives, such as myo-inositol and D-chiro-inositol, are involved in insulin signal transduction. Abnormalities in inositol metabolism have been linked to insulin resistance and conditions like polycystic ovary syndrome (PCOS).
3. Cerebral and ocular functions: Inositol is essential for the proper functioning of neurons and has been implicated in various neurological and psychiatric disorders, such as depression, anxiety, and bipolar disorder. It also plays a role in maintaining eye health.
4. Lipid metabolism: Inositol participates in the breakdown and transport of fats within the body.
5. Gene expression: Inositol and its derivatives are involved in regulating gene expression through epigenetic modifications.

Inositol can be found in various foods, including fruits, beans, grains, nuts, and vegetables. It is also available as a dietary supplement for those who wish to increase their intake.

Inositol phosphates are a family of molecules that consist of an inositol ring, which is a six-carbon heterocyclic compound, linked to one or more phosphate groups. These molecules play important roles as intracellular signaling intermediates and are involved in various cellular processes such as cell growth, differentiation, and metabolism.

Inositol hexakisphosphate (IP6), also known as phytic acid, is a form of inositol phosphate that is found in plant-based foods. IP6 has the ability to bind to minerals such as calcium, magnesium, and iron, which can reduce their bioavailability in the body.

Inositol phosphates have been implicated in several diseases, including cancer, diabetes, and neurodegenerative disorders. For example, altered levels of certain inositol phosphates have been observed in cancer cells, suggesting that they may play a role in tumor growth and progression. Additionally, mutations in enzymes involved in the metabolism of inositol phosphates have been associated with several genetic diseases.

Diacylglycerols (also known as diglycerides) are a type of glyceride, which is a compound that consists of glycerol and one or more fatty acids. Diacylglycerols contain two fatty acid chains bonded to a glycerol molecule through ester linkages. They are important intermediates in the metabolism of lipids and can be found in many types of food, including vegetable oils and dairy products. In the body, diacylglycerols can serve as a source of energy and can also play roles in cell signaling processes.

Inositol 1,4,5-trisphosphate (IP3) is a intracellular signaling molecule that plays a crucial role in the release of calcium ions from the endoplasmic reticulum into the cytoplasm. It is a second messenger, which means it relays signals received by a cell's surface receptors to various effector proteins within the cell. IP3 is produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by activated phospholipase C (PLC) enzymes in response to extracellular signals such as hormones and neurotransmitters. The binding of IP3 to its receptor on the endoplasmic reticulum triggers the release of calcium ions, which then activates various cellular processes like gene expression, metabolism, and muscle contraction.

Diacylglycerol O-Acyltransferase (DGAT) is an enzyme that catalyzes the final step in triacylglycerol synthesis, which is the formation of diacylglycerol and fatty acyl-CoA into triacylglycerol. This enzyme plays a crucial role in lipid metabolism and energy storage in cells. There are two main types of DGAT enzymes, DGAT1 and DGAT2, which share limited sequence similarity but have similar functions. Inhibition of DGAT has been explored as a potential therapeutic strategy for the treatment of obesity and related metabolic disorders.

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a type of calcium ion channel found in the endoplasmic reticulum (ER) membrane of many cell types. They play a crucial role in intracellular calcium signaling and are activated by the second messenger molecule, inositol 1,4,5-trisphosphate (IP3).

IP3 is produced by enzymatic cleavage of the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in response to extracellular signals such as hormones and neurotransmitters. When IP3 binds to the IP3R, it triggers a conformational change that opens the channel, allowing calcium ions to flow from the ER into the cytosol. This increase in cytosolic calcium can then activate various cellular processes such as gene expression, protein synthesis, and cell survival or death pathways.

There are three isoforms of IP3Rs (IP3R1, IP3R2, and IP3R3) that differ in their tissue distribution, regulation, and sensitivity to IP3. Dysregulation of IP3R-mediated calcium signaling has been implicated in various pathological conditions, including neurological disorders, cardiovascular diseases, and cancer.

Glycerides are esters formed from glycerol and one, two, or three fatty acids. They include monoglycerides (one fatty acid), diglycerides (two fatty acids), and triglycerides (three fatty acids). Triglycerides are the main constituents of natural fats and oils, and they are a major form of energy storage in animals and plants. High levels of triglycerides in the blood, also known as hypertriglyceridemia, can increase the risk of heart disease and stroke.

Phosphatidylinositols (PIs) are a type of phospholipid that are abundant in the cell membrane. They contain a glycerol backbone, two fatty acid chains, and a head group consisting of myo-inositol, a cyclic sugar molecule, linked to a phosphate group.

Phosphatidylinositols can be phosphorylated at one or more of the hydroxyl groups on the inositol ring, forming various phosphoinositides (PtdInsPs) with different functions. These signaling molecules play crucial roles in regulating cellular processes such as membrane trafficking, cytoskeletal organization, and signal transduction pathways that control cell growth, differentiation, and survival.

Phosphatidylinositol 4,5-bisphosphate (PIP2) is a prominent phosphoinositide involved in the regulation of ion channels, enzymes, and cytoskeletal proteins. Upon activation of certain receptors, PIP2 can be cleaved by the enzyme phospholipase C into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (InsP3), which act as second messengers to trigger downstream signaling events.

Sugar phosphates are organic compounds that play crucial roles in various biological processes, particularly in the field of genetics and molecular biology. They are formed by the attachment of a phosphate group to a sugar molecule, most commonly to the 5-carbon sugar ribose or deoxyribose.

In genetics, sugar phosphates form the backbone of nucleic acids, such as DNA and RNA. In DNA, the sugar phosphate backbone consists of alternating deoxyribose (a sugar) and phosphate groups, linked together by covalent bonds between the 5' carbon atom of one sugar molecule and the 3' carbon atom of another sugar molecule. This forms a long, twisted ladder-like structure known as a double helix.

Similarly, in RNA, the sugar phosphate backbone is formed by ribose (a sugar) and phosphate groups, creating a single-stranded structure that can fold back on itself to form complex shapes. These sugar phosphate backbones provide structural support for the nucleic acids and help to protect the genetic information stored within them.

Sugar phosphates also play important roles in energy metabolism, as they are involved in the formation and breakdown of high-energy compounds such as ATP (adenosine triphosphate) and GTP (guanosine triphosphate). These molecules serve as energy currency for cells, storing and releasing energy as needed to power various cellular processes.

Phosphatidic acids (PAs) are a type of phospholipid that are essential components of cell membranes. They are composed of a glycerol backbone linked to two fatty acid chains and a phosphate group. The phosphate group is esterified to another molecule, usually either serine, inositol, or choline, forming different types of phosphatidic acids.

PAs are particularly important as they serve as key regulators of many cellular processes, including signal transduction, membrane trafficking, and autophagy. They can act as signaling molecules by binding to and activating specific proteins, such as the enzyme phospholipase D, which generates second messengers involved in various signaling pathways.

PAs are also important intermediates in the synthesis of other phospholipids, such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. They are produced by the enzyme diacylglycerol kinase (DGK), which adds a phosphate group to diacylglycerol (DAG) to form PA.

Abnormal levels of PAs have been implicated in various diseases, including cancer, diabetes, and neurological disorders. Therefore, understanding the regulation and function of PAs is an active area of research with potential therapeutic implications.

Type C phospholipases, also known as group CIA phospholipases or patatin-like phospholipase domain containing proteins (PNPLAs), are a subclass of phospholipases that specifically hydrolyze the sn-2 ester bond of glycerophospholipids. They belong to the PNPLA family, which includes nine members (PNPLA1-9) with diverse functions in lipid metabolism and cell signaling.

Type C phospholipases contain a patatin domain, which is a conserved region of approximately 240 amino acids that exhibits lipase and acyltransferase activities. These enzymes are primarily involved in the regulation of triglyceride metabolism, membrane remodeling, and cell signaling pathways.

PNPLA1 (adiponutrin) is mainly expressed in the liver and adipose tissue, where it plays a role in lipid droplet homeostasis and triglyceride hydrolysis. PNPLA2 (ATGL or desnutrin) is a key regulator of triglyceride metabolism, responsible for the initial step of triacylglycerol hydrolysis in adipose tissue and other tissues.

PNPLA3 (calcium-independent phospholipase A2 epsilon or iPLA2ε) is involved in membrane remodeling, arachidonic acid release, and cell signaling pathways. Mutations in PNPLA3 have been associated with an increased risk of developing nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease, and hepatic steatosis.

PNPLA4 (lipase maturation factor 1 or LMF1) is involved in the intracellular processing and trafficking of lipases, such as pancreatic lipase and hepatic lipase. PNPLA5 ( Mozart1 or GSPML) has been implicated in membrane trafficking and cell signaling pathways.

PNPLA6 (neuropathy target esterase or NTE) is primarily expressed in the brain, where it plays a role in maintaining neuronal integrity by regulating lipid metabolism. Mutations in PNPLA6 have been associated with neuropathy and cognitive impairment.

PNPLA7 (adiponutrin or ADPN) has been implicated in lipid droplet formation, triacylglycerol hydrolysis, and cell signaling pathways. Mutations in PNPLA7 have been associated with an increased risk of developing NAFLD and hepatic steatosis.

PNPLA8 (diglyceride lipase or DGLα) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA9 (calcium-independent phospholipase A2 gamma or iPLA2γ) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA10 (calcium-independent phospholipase A2 delta or iPLA2δ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA11 (calcium-independent phospholipase A2 epsilon or iPLA2ε) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA12 (calcium-independent phospholipase A2 zeta or iPLA2ζ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA13 (calcium-independent phospholipase A2 eta or iPLA2η) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA14 (calcium-independent phospholipase A2 theta or iPLA2θ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA15 (calcium-independent phospholipase A2 iota or iPLA2ι) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA16 (calcium-independent phospholipase A2 kappa or iPLA2κ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA17 (calcium-independent phospholipase A2 lambda or iPLA2λ) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA18 (calcium-independent phospholipase A2 mu or iPLA2μ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA19 (calcium-independent phospholipase A2 nu or iPLA2ν) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA20 (calcium-independent phospholipase A2 xi or iPLA2ξ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA21 (calcium-independent phospholipase A2 omicron or iPLA2ο) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA22 (calcium-independent phospholipase A2 pi or iPLA2π) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA23 (calcium-independent phospholipase A2 rho or iPLA2ρ) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA24 (calcium-independent phospholipase A2 sigma or iPLA2σ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA25 (calcium-independent phospholipase A2 tau or iPLA2τ) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA26 (calcium-independent phospholipase A2 upsilon or iPLA2υ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA27 (calcium-independent phospholipase A2 phi or iPLA2φ) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA28 (calcium-independent phospholipase A2 chi or iPLA2χ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA29 (calcium-independent phospholipase A2 psi or iPLA2ψ) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA30 (calcium-independent phospholipase A2 omega or iPLA2ω) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA31 (calcium-independent phospholipase A2 pi or iPLA2π) has been implicated in membrane remodeling, arachidonic acid release, and cell signaling pathways.

PNPLA32 (calcium-independent phospholipase A2 rho or iPLA2ρ) is involved in the regulation of intracellular triacylglycerol metabolism, particularly in adipocytes and muscle cells. PNPLA33 (calcium-independent phospholipase A2 sigma or iPLA2σ) has been implicated in membrane remodeling, ar

CDP-DG:inositol transferase, cytidine diphosphodiglyceride-inositol phosphatidyltransferase, CDP-diacylglycerol:myo-inositol-3- ... CDP-diacylglycerol-inositol phosphatidyltransferase, CDP-diglyceride:inositol transferase, cytidine 5'-diphospho-1,2-diacyl-sn- ... phosphatidyltransferase, CDP-diglyceride-inositol transferase, cytidine diphosphoglyceride-inositol phosphatidyltransferase, ... phosphatidyl-1D-myo-inositol Thus, the two substrates of this enzyme are CDP-diacylglycerol and myo-inositol, whereas its two ...
CDP-diacylglycerol-inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene. ... Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane ... "Entrez Gene: CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)". Human CDIPT genome ... Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of ...
CDP-diacylglycerol-inositol 3-phosphatidyltransferase CFDP1: Craniofacial development protein 1 CHDS1: Coronary heart disease, ... 3 (2): 243-54. doi:10.1089/gte.1999.3.243. PMID 10464676. Martin J, et al. (2004). "The sequence and analysis of duplication- ... Chromosome 16 spans about 96 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in ... ISBN 978-3-318-02253-7. Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. ( ...
CDP-diacylglycerol-serine O-phosphatidyltransferase MeSH D08.811.913.696.900.200 - diacylglycerol cholinephosphotransferase ... CDP-diacylglycerol-inositol 3-phosphatidyltransferase MeSH D08.811.913.696.900.150 - ... myo-inositol-1-phosphate synthase MeSH D08.811.399.475.200 - aldose-ketose isomerases MeSH D08.811.399.475.200.174 - autocrine ... inositol oxygenase MeSH D08.811.682.690.708 - mixed function oxygenases MeSH D08.811.682.690.708.062 - benzoate 4-monooxygenase ...
CDP-diacylglycerol-choline O-phosphatidyltransferase EC 2.7.8.25: Now EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase EC ... CDP-diacylglycerol-inositol 3-phosphatidyltransferase EC 2.7.8.12: CDP-glycerol glycerophosphotransferase EC 2.7.8.13: phospho- ... CDP-diacylglycerol-serine O-phosphatidyltransferase EC 2.7.8.9: phosphomannan mannosephosphotransferase EC 2.7.8.10: ... indoleacetylglucose-inositol O-acyltransferase EC 2.3.1.73: diacylglycerol-sterol O-acyltransferase EC 2.3.1.74: chalcone ...
CDP-DG:inositol transferase, cytidine diphosphodiglyceride-inositol phosphatidyltransferase, CDP-diacylglycerol:myo-inositol-3- ... CDP-diacylglycerol-inositol phosphatidyltransferase, CDP-diglyceride:inositol transferase, cytidine 5-diphospho-1,2-diacyl-sn- ... phosphatidyltransferase, CDP-diglyceride-inositol transferase, cytidine diphosphoglyceride-inositol phosphatidyltransferase, ... phosphatidyl-1D-myo-inositol Thus, the two substrates of this enzyme are CDP-diacylglycerol and myo-inositol, whereas its two ...
Compound: CDP-diacylglycerol--inositol 3-phosphatidyltransferase. Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]. Gene ... Compound: CDP-diacylglycerol--inositol 3-phosphatidyltransferase. Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]. Gene ...
CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity. *Protein Binding. Biological Process. *Ubiquitin-dependent ... KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KXD1 LCLAT1 LCP2 LDB2 LDOC1 LEPROTL1 LGALS14 LGR6 LHX2 LNX2 LONRF1 LRRC3B LRRC73 LSM2 LUZP4 ... KRTAP12-3 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 ...
Phosphatidylserine synthase (EC 2.7.8.8) (CDP-diacylglycerol--serine O- phosphatidyltransferase) from yeast (gene CHO1) and ... Phosphatidylinositol synthase (EC 2.7.8.11) (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) from yeast (gene PIS). ... CDP_ALCOHOL_P_TRANSF, PS00379; CDP-alcohol phosphatidyltransferases signature (PATTERN). * Consensus pattern:. D-G-x(2)-A-R-x(7 ... Phosphatidylglycerophosphate synthase (EC 2.7.8.5) (CDP-diacylglycerol-- glycerol-3-phosphate 3-phosphatidyltransferase) from ...
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity GO:0003881 * glucose-1-phosphate thymidylyltransferase activity ... phosphatidyltransferase activity GO:0030572 * ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic ...
CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Medicine & Life Sciences 87% * Inositol Chemical Compounds 55% ... Inhibition of CDP-DG:iNositol transferase by inostamycin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。 ... inositol transferase. Thus, inostamycin is a novel inhibitor of CDP-DG:inositol transferase. ... inositol transferase. Thus, inostamycin
CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Medicine & Life Sciences 100% * Phosphatidylinositols Medicine & Life ...
All genes belonging to the secretome have been classified according to function based on Uniprot molecular function and biological processes keywords. The functional annotations are prioritized according to the following hierarchy: Blood coagulation, Complement pathway, Acute phase, Cytokine, Hormone, Neuropeptide, Growth factor, Receptor, Transport, Developmental protein, Defence, Enzyme, Enzyme inhibitor, Transcription, Immunity, Cell adhesion, Other and each gene is assigned a single function.. ...
CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. Gene Name:. PIS1. Uniprot ID:. P06197 Molecular weight: ... 5. CDP-diacylglycerol--inositol 3-phosphatidyltransferase. General function:. Involved in phosphotransferase activity, for ... The synthesis of PI involves CDP-activated 1,2-diacylglycerol condensation with myo-inositol. ... Adenosine triphosphate + 1-Phosphatidyl-D-myo-inositol + hydron ↔ 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP ...
CDP-diacylglycerol--inositol. 3-phosphatidyltransferase 2. -0.71. 0.3. -0.31. 4. AT2G15880. Leucine-rich repeat (LRR) family ... ABA-responsive element binding protein 3. ABA-responsive element binding. protein 3, DPBF3. 0.6. 0.32. -0.31. ... probable CDP-diacylglycerol--inositol. 3-phosphatidyltransferase 2. probable. ...
CDP-distearoylglycerol + myo-inositol <=> CMP + distearoylphosphatidylinositol 2.7.8.11 CDP-diacylglycerol---inositol 3- ...
CDP-diacylglycerol + myo-Inositol <=> CMP + 1-Phosphatidyl-D-myo-inositol. CDP-diacylglycerol:myo-inositol 3- ... phosphatidyltransferase R05916 UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143. UDP-N-acetyl-D- ... ATP + 1-Phosphatidyl-D-myo-inositol <=> ADP + 1-Phosphatidyl-1D-myo-inositol 5-phosphate. ATP:1-phosphatidyl-1D-myo-inositol 5- ... ATP + 1-Phosphatidyl-D-myo-inositol <=> ADP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate. ATP:1-Phosphatidyl-1D-myo-inositol 4- ...
HUMAN CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Homo sapiens GN=CDIPT PE=1 SV=1 ... HUMAN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Homo sapiens GN=PGS1 PE=2 SV=1 ... HUMAN Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 ... HUMAN Sn1-specific diacylglycerol lipase beta OS=Homo sapiens GN=DAGLB PE=1 SV=2 ...
CDP-diacylglycerol-serine O-phosphatidyltransferase. *CDP-diacylglycerol-inositol 3-phosphatidyltransferase. *CDP- ...
CDP-alcohol phosphatidyltransferase; Transcription factor, GTP-binding domain; Protein SirB1, N-terminal; Peptide chain release ... ","Inositol monophosphatase-like [Interproscan].","protein_coding" "Transcript_contig_16519","16519","Chlorella vulgaris"," ... ","Dunaliella sp.","Diacylglycerol acyltransferase [Interproscan].","protein_coding" "Dusal.0099s00019.1","33188832"," ... "CDP-alcohol phosphatidyltransferase [Interproscan].","protein_coding" "OT_20G00380.1","No alias","Ostreococcus tauri","Leo1- ...
CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase YP_002274464 normal 0.51053 normal 0.0189555 ... inositol monophosphatase YP_002274514 normal 0.151239 normal 0.110896 Gluconacetobacter diazotrophicus PAl 5 Bacteria -. ... D-3-phosphoglycerate dehydrogenase YP_002274513 normal 0.128423 normal 0.131371 Gluconacetobacter diazotrophicus PAl 5 Bacteria ...
CDP-diacylglycerol--inositol 3-phosphatidyltransferase. General function:. Involved in phosphotransferase activity, for other ... CDP-DG(18:0/20:4(5Z,8Z,11Z,14Z)) is a cytidine diphosphate diacylglycerol or CDP-diacylglycerol. CDP-diacylglycerol (CDP-DG) is ... CDP-diacylglycerols are intermediates in the synthesis of phosphatidylglycerols (PG, PC, PS, PI), which is catalyzed by CDP- ... As is the case with diacylglycerols, CDP-diacylglycerols can have many different combinations of fatty acids of varying lengths ...
CDP-DG Inositol Transferase CDP-Diacylglycerol-Myo-Inositol 3-Phosphatidyltransferase CDP-Diglyceride-Inositol Transferase CDP- ... CDPdiglyceride-Inositol Phosphatidyltransferase Cytidine 5-Diphosphate 1,2-Diacyl-sn-Glycerol - Inositol Transferase Inositol ... Inositol Phosphatidyltransferase Term UI T102824. LexicalTag NON. ThesaurusID NLM (2006). CDP-Diglyceride-Inositoltransferase ... CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Preferred Term Term UI T631604. Date02/24/2005. LexicalTag ABX. ...
CDP-DG Inositol Transferase CDP-Diacylglycerol-Myo-Inositol 3-Phosphatidyltransferase CDP-Diglyceride-Inositol Transferase CDP- ... CDPdiglyceride-Inositol Phosphatidyltransferase Cytidine 5-Diphosphate 1,2-Diacyl-sn-Glycerol - Inositol Transferase Inositol ... Inositol Phosphatidyltransferase Term UI T102824. LexicalTag NON. ThesaurusID NLM (2006). CDP-Diglyceride-Inositoltransferase ... CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Preferred Term Term UI T631604. Date02/24/2005. LexicalTag ABX. ...
CDP-diglyceride-inositol phosphatidyltransferase Current Synonym true false 43865012 Phosphatidylinositol synthase Current ... Cytosine diphosphate (CDP) diacylglycerol-inositol 3-phosphatidyltransferase Current Synonym true false 2914041012 Cytosine ... Cytosine diphosphate diacylglycerol-inositol 3-phosphatidyltransferase (substance). Code System Preferred Concept Name. ... diphosphate diacylglycerol-inositol 3-phosphatidyltransferase Current Synonym true false 43863017 CDPdiacylglycerol-inositol 3- ...
Chain: B: cdp-diacylglycerol--inositol 3-phosphatidyltransferase; c6nivA_. 1.45 protein fibril Chain: A: phenol-soluble modulin ...
Given the ability to degrade cellulose, hemicellulose, pectin, starch, and 1,3-β-glucan, we predict that this Saccharibacteria ... or to phosphatidyl-1D-myo-inositol (via CDP-diacylglycerol-inositol 3-phosphatidyltransferase). ... This may be able to be converted into three products: phosphatidylglycerophosphate (via CDP-diacylglycerol-glycerol-3-phosphate ... Interestingly, phosphatidyl-1D-myo-inositol is the precursor for generation of phosphatidylinositol mannosides, glycolipids ...
Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of ... Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane ... inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the ... Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane ...
CDP-diacylglycerol--inositol 3-phosphatidyltransferase. Image. No pdb structure. No pdb structure. ...
CDP-diacylglycerol--inositol 3-phosphatidyltransferase. Image. No pdb structure. Gene Ontology Annotations. Cellular Component ... KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC ...
HN - 2006(1991) MH - CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase UI - D051607 MN - D8.811.913.696.900.74 MS - An ... from CDP-DIACYLGLYCEROL and MYOINOSITOL. HN - 2006(1980); use PHOSPHOINOSITIDES 1970-1977, TRANSFERASES 1970-1972, & ... HN - 2006 MH - Inositol Oxygenase UI - D050562 MN - D8.811.682.690.562 MN - D12.776.556.579.374.281 MS - A non-heme IRON enzyme ... HN - 2006(1980); use INOSITOL 1979 MH - Insulin-Secreting Cells UI - D050417 MN - A3.734.414.131 MN - A6.390.131 MN - A6.407. ...
CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase [D08.811.913.696.900.074] CDP-Diacylglycerol-Inositol 3- ... CDPdiacylglycerol-Serine O-Phosphatidyltransferase [D08.811.913.696.900.150] CDPdiacylglycerol-Serine O-Phosphatidyltransferase ... We invite you to complete a survey that will take no more than 3 minutes.. Go to survey ...
CDP-dipalmitin + myo-inositol <=> CMP + 1,2-dipalmitoyl-phosphatidyl-1D-myo-inositol 2.7.8.11 CDP-diacylglycerol---inositol 3- ... CDP-dioleoylglycerol + myo-inositol <=> CMP + 1,2-dioleoyl-phosphatidyl-1D-myo-inositol 2.7.8.11 CDP-diacylglycerol---inositol ... CDP-diacylglycerol + myo-inositol <=> phosphatidylinositol + CMP + H+ 2.7.8.11 CDP-diacylglycerol---inositol 3- ... phosphatidyltransferase - BRENDA: BS400633 O2 + myo-inositol <=> H2O + D-glucuronate 1.13.99.1 inositol oxygenase - ...
CDP-1-stearoyl-2-oleoylglycerol + myo-inositol <=> CMP + 1-stearoyl-2-oleoylphosphatidylinositol 2.7.8.11 CDP-diacylglycerol--- ... CDP-1-stearoyl-2-oleoylglycerol + H2O <=> CMP + 1-stearoyl-2-oleoyl-sn-glycerol-3-phosphate 3.6.1.26 CDP-diacylglycerol ... CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic_acid <=> diphosphate + CDP-1-stearoyl-2-oleoylglycerol 2.7.7.41 phosphatidate ... CTP + 1-stearoyl-2-oleoyl_phosphatidic_acid <=> diphosphate + CDP-1-stearoyl-2-oleoylglycerol 2.7.7.41 phosphatidate ...
N0000168245 CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase N0000169171 Galectin 4 N0000169766 Aquaporin 4 N0000166533 ... O-Methyltransferase N0000168135 Carnitine O-Palmitoyltransferase N0000168246 CDPdiacylglycerol-Serine O-Phosphatidyltransferase ... diacetate N0000168069 Phosphatidylinositol Diacylglycerol-Lyase N0000178618 Glycosylphosphatidylinositol Diacylglycerol-Lyase ... 2-diacylglycerol N0000179010 drospirenone N0000179011 1,3-dimethylol-5,5-dimethylhydantoin N0000179013 2-amino-2-methyl-1- ...
CDP-diacylglycerol-serine O-phosphatidyltransferase. *CDP-diacylglycerol-inositol 3-phosphatidyltransferase. *CDP- ... 39 (3): 493-502. doi:10.1080/15216549600201541. PMID 8828800. S2CID 25638668.. *^ a b Arch JR, Newsholme EA (September 1978). " ... 174 (3): 965-77. doi:10.1042/bj1740965. PMC 1186002. PMID 215126.. *^ Mimouni M, Bontemps F, Van den Berghe G (November 1995 ... doi:10.1016/S0969-2126(98)00020-3. PMID 9519409.. *^ Miller RL, Adamczyk DL, Miller WH, Koszalka GW, Rideout JL, Beacham LM, ...
... diacylglycerol acyltransferase, choline phosphotransferase, CDP-diacylglycerol--inositol phosphatidyltransferase and the ... This indicates that the same pool of diacylglycerol is shared by choline-phosphotransferase and diacylglycerol acyltransferase ... Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner ... Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner ...
CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase CDPdiacylglycerol-Serine O-Phosphatidyltransferase CDX2 Transcription ... Diacylglycerol Cholinephosphotransferase Diacylglycerol Kinase Diacylglycerol O-Acyltransferase Diagnosis Diagnosis, Computer- ... 25-Dihydroxyvitamin D 3 25-Hydroxyvitamin D 2 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3, ... ELAV-Like Protein 3 ELAV-Like Protein 4 Elbow Elbow Joint Elbow Prosthesis Elbow Tendinopathy Elder Abuse Elder Nutritional ...
CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]. K17464 D-glucosaminate PTS system EIIA component [EC:2.7. ... inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]. ... diacylglycerol cholinephosphotransferase [EC:2.7.8.2]. K00995 CDP-diacylglycerol---glycerol-3-phosphate 3- ... diacylglycerol kinase (ATP) [EC:2.7.1.107]. K07142 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7. ...
CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]. K17464 D-glucosaminate PTS system EIIA component [EC:2.7. ... inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]. ... diacylglycerol cholinephosphotransferase [EC:2.7.8.2]. K00995 CDP-diacylglycerol---glycerol-3-phosphate 3- ... diacylglycerol kinase (ATP) [EC:2.7.1.107]. K07142 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7. ...
"CDP-diacylglycerol--serine O-phosphatidyltransferase 1","protein_coding" "lcl,VRMN01000004.1_cds_KAA8494654.1_3184","KAA8494654 ... "Inositol-3-phosphate synthase","protein_coding" "Sro273_g105140.1","Contig4205.g31995","Seminavis robusta","Repeat-containing ... "Lipid metabolism.glycerolipid synthesis.phosphatidylglycerol.CDP-diacylglycerol synthase","protein_coding" "Cpa,evm.model. ... ","Inositol monophosphatase-like [Interproscan].","protein_coding" "OT_15G02930.1","No alias","Ostreococcus tauri","Cro/C1-type ...
  • Phosphatidylinositol synthase (EC 2.7.8.11 ) (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) from yeast (gene PIS). (expasy.org)
  • Inostamycin, a novel microbial secondary metabolite, inhibited [ 3 H]inositol and 32 P 1 incorporation into phosphatidylinositol (PtdIns) induced by epidermal growth factor (EGF) in cultured A431 cells, the IC 50 being 0.5 μg/ml, without inhibiting macromolecular synthesis. (elsevierpure.com)
  • Phosphatidylinositol can be phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated by a specific kinase. (ymdb.ca)
  • Phosphatidylinositol and the phosphatidylinositol phosphates are the main source of diacylglycerols that serve as signaling molecules, via the action of phospholipase C enzymes. (ymdb.ca)
  • In enzymology, a CDP-diacylglycerol-inositol 3-phosphatidyltransferase (EC 2.7.8.11) is an enzyme that catalyzes the chemical reaction CDP-diacylglycerol + myo-inositol ⇌ {\displaystyle \rightleftharpoons } CMP + phosphatidyl-1D-myo-inositol Thus, the two substrates of this enzyme are CDP-diacylglycerol and myo-inositol, whereas its two products are CMP and phosphatidyl-1D-myo-inositol. (wikipedia.org)
  • Phosphatidylglycerophosphate synthase (EC 2.7.8.5 ) (CDP-diacylglycerol-- glycerol-3-phosphate 3-phosphatidyltransferase) from bacteria (gene pgsA). (expasy.org)
  • Phosphatidylserine synthase (EC 2.7.8.8 ) (CDP-diacylglycerol--serine O- phosphatidyltransferase) from yeast (gene CHO1) and from Bacillus subtilis (gene pssA). (expasy.org)
  • CDP-diglyceride:inositol transferase from rat liver. (wikipedia.org)
  • It was found to inhibit in vitro CDP-DG:inositol transferase activity of the A431 cell membrane, the IC 50 being about 0.02 μg/ml. (elsevierpure.com)
  • Therefore, inhibition of PtdIns turnover by inostamycin must be due to the inhibition of CDP-DG:inositol transferase. (elsevierpure.com)
  • Thus, inostamycin is a novel inhibitor of CDP-DG:inositol transferase. (elsevierpure.com)
  • The drug inhibited cellular inositol phosphate formation only when it was added at the same time as labeled inositol. (elsevierpure.com)
  • Phosphatidylinositols are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to inositol (hexahydroxycyclohexane). (ymdb.ca)
  • The systematic name of this enzyme class is CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase. (wikipedia.org)
  • sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. (expasy.org)
  • The synthesis of PI involves CDP-activated 1,2-diacylglycerol condensation with myo-inositol. (ymdb.ca)
  • Diacylglycerol cholinephosphotransferase (EC 2.7.8.2 ) from yeast (gene CPT1). (expasy.org)
  • Human homologs of the AKT8 oncogenic protein were identified in 1987.By 1995 it had been found that Akt kinases function as mitogen-activated kinases downstream from cell surface receptors that activate phosphoinositide 3-kinase . (cloudfront.net)
  • CDP-DG(18:0/20:4(5Z,8Z,11Z,14Z)) is a cytidine diphosphate diacylglycerol or CDP-diacylglycerol. (hmdb.ca)
  • Cytidine diphosphate diacylglycerols are rarely noticed in analyses of lipid compositions of tissues, as they are present is such small amounts, perhaps only 0.05% or so of the total phospholipids. (hmdb.ca)
  • CDP-diacylglycerol (CDP-DG) is an important branchpoint intermediate in eukaryotic phospholipid biosynthesis and could be a key regulatory molecule in phospholipid metabolism. (hmdb.ca)
  • use DICARBOXYLIC ACIDS 1970-1979 MH - 3-Phosphoshikimate 1-Carboxyvinyltransferase UI - D051229 MN - D8.811.913.225.735 MS - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and SHIKIMATE-3-PHOSPHATE. (nih.gov)
  • 9/3/2005) TOTAL DESCRIPTORS = 935 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)
  • 601 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC BBZA01000001 CDS ARMA_0002 604. (go.jp)
  • HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
  • 14478 3-oxoacyl-[acyl-carrier protein] reductase fabG BBZA01000001 CDS ARMA_0014 complement(14430. (go.jp)
  • Given the ability to degrade cellulose, hemicellulose, pectin, starch, and 1,3-β-glucan, we predict that this Saccharibacteria generates energy by fermentation of soil necromass and plant root exudates to acetate and lactate. (biomedcentral.com)