Cdh1 Proteins: Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.Hernia, Diaphragmatic: Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.Anaphase-Promoting Complex-Cyclosome: An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.Ubiquitin-Protein Ligase Complexes: Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Cdc20 Proteins: Highly conserved proteins that specifically bind to and activate the anaphase-promoting complex-cyclosome, promoting ubiquitination and proteolysis of cell-cycle-regulatory proteins. Cdc20 is essential for anaphase-promoting complex activity, initiation of anaphase, and cyclin proteolysis during mitosis.Phenyl Ethers: Ethers that are linked to a benzene ring structure.Carbohydrate Dehydrogenases: Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome: A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc5, along with Apc4, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.Cell Cycle Proteins: Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome: A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc4, along with Apc5, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.1-Pyrroline-5-Carboxylate Dehydrogenase: An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome: The largest subunit of the anaphase-promoting complex. It acts primarily as a scaffold for the proper organization and arrangement of subunits. The C-terminal region of Apc1 contains a series of tandem amino acid repeats that are also seen in the 26S proteasome regulatory particle, and may assist with forming and stabilizing protein-protein interactions.Securin: Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.Mitosis: A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.Cyclin B: A cyclin subtype that is transported into the CELL NUCLEUS at the end of the G2 PHASE. It stimulates the G2/M phase transition by activating CDC2 PROTEIN KINASE.Stomach Neoplasms: Tumors or cancer of the STOMACH.Ligases: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome: A highly evolutionarily conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc subunits 6, 7, and 8, have been shown to mediate protein-protein interactions, suggesting that Apc3 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to co-activators and APC-C inhibitors.S-Phase Kinase-Associated Proteins: A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.Headache Disorders: Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Ubiquitination: The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.Prometaphase: The phase of cell nucleus division following PROPHASE, when the breakdown of the NUCLEAR ENVELOPE occurs and the MITOTIC SPINDLE APPARATUS enters the nuclear region and attaches to the KINETOCHORES.Anaphase: The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome: Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome: Together with the Apc2 subunit, forms the catalytic core of the E3 ubiquitin ligase, anaphase-promoting complex-cyclosome. It has a RING H2 domain which interacts with the cullin domain of Apc2. Apc11 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.Ubiquitin-Protein Ligases: A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.Usher Syndromes: Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome: Apc10 is necessary for coactivator-dependent substrate recognition by the anaphase-promoting complex-cyclosome. It binds the Apc2 subunit, which is a part of the catalytic core, and interacts with coactivators Cdh1 or Cdc20 to recruit substrates to the complex.Stereocilia: Mechanosensing organelles of hair cells which respond to fluid motion or fluid pressure changes. They have various functions in many different animals, but are primarily used in hearing.Germ-Line Mutation: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.G1 Phase: The period of the CELL CYCLE preceding DNA REPLICATION in S PHASE. Subphases of G1 include "competence" (to respond to growth factors), G1a (entry into G1), G1b (progression), and G1c (assembly). Progression through the G1 subphases is effected by limiting growth factors, nutrients, or inhibitors.Hair Cells, Auditory: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Cellobiose: A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.Hypotrichosis: Presence of less than the normal amount of hair. (Dorland, 27th ed)Presbycusis: Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.Diaphragm: The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.Rodenticides: Substances used to destroy or inhibit the action of rats, mice, or other rodents.Cell Adhesion: Adherence of cells to surfaces or to other cells.Rodent Control: The reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means.Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Trichomes: Hair-like extensions on specialized epidermal surfaces of plants which protect against damage from insects, animals, light degradation and fungal infection. Trichomes may also occur on certain unicellular EUKARYOTES.Arabidopsis Proteins: Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Gene Expression Regulation, Plant: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.Endoreduplication: A type of nuclear polyploidization in which multiple cycles of DNA REPLICATION occur in the absence of CELL DIVISION and result in a POLYPLOID CELL.Plant Epidermis: A thin layer of cells forming the outer integument of seed plants and ferns. (Random House Unabridged Dictionary, 2d ed)

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. (1/136)

BACKGROUND: Exit from mitosis requires inactivation of mitotic cyclin-dependent kinases (CDKs). A key mechanism of CDK inactivation is ubiquitin-mediated cyclin proteolysis, which is triggered by the late mitotic activation of a ubiquitin ligase known as the anaphase-promoting complex (APC). Activation of the APC requires its association with substoichiometric activating subunits termed Cdc20 and Hct1 (also known as Cdh1). Here, we explore the molecular function and regulation of the APC regulatory subunit Hct1 in Saccharomyces cerevisiae. RESULTS: Recombinant Hct1 activated the cyclin-ubiquitin ligase activity of APC isolated from multiple cell cycle stages. APC isolated from cells arrested in G1, or in late mitosis due to the cdc14-1 mutation, was more responsive to Hct1 than APC isolated from other stages. We found that Hct1 was phosphorylated in vivo at multiple CDK consensus sites during cell cycle stages when activity of the cyclin-dependent kinase Cdc28 is high and APC activity is low. Purified Hct1 was phosphorylated in vitro at these sites by purified Cdc28-cyclin complexes, and phosphorylation abolished the ability of Hct1 to activate the APC in vitro. The phosphatase Cdc14, which is known to be required for APC activation in vivo, was able to reverse the effects of Cdc28 by catalyzing Hct1 dephosphorylation and activation. CONCLUSIONS: We conclude that Hct1 phosphorylation is a key regulatory mechanism in the control of cyclin destruction. Phosphorylation of Hct1 provides a mechanism by which Cdc28 blocks its own inactivation during S phase and early mitosis. Following anaphase, dephosphorylation of Hct1 by Cdc14 may help initiate cyclin destruction.  (+info)

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. (2/136)

The separation of sister chromatids in anaphase is followed by spindle disassembly and cytokinesis. These events are governed by the anaphase-promoting complex (APC), which triggers the ubiquitin-dependent proteolysis of key regulatory proteins: anaphase requires the destruction of the anaphase inhibitor Pds1, whereas mitotic exit requires the destruction of mitotic cyclins and the inactivation of Cdk1. We find that Pds1 is not only an inhibitor of anaphase, but also blocks cyclin destruction and mitotic exit by a mechanism independent of its effects on sister chromatid separation. Pds1 is also required for the mitotic arrest and inhibition of cyclin destruction that occurs after DNA damage. Even in anaphase cells, where Pds1 levels are normally low, DNA damage stabilizes Pds1 and prevents cyclin destruction and mitotic exit. Pds1 blocks cyclin destruction by inhibiting its binding partner Esp1. Mutations in ESP1 delay cyclin destruction; overexpression of ESP1 causes premature cyclin destruction in cells arrested in metaphase by spindle defects and in cells arrested in metaphase and anaphase by DNA damage. The effects of Esp1 are dependent on Cdc20 (an activating subunit of the APC) and on several additional proteins (Cdc5, Cdc14, Cdc15, Tem1) that form a regulatory network governing mitotic exit. We speculate that the inhibition of cyclin destruction by Pds1 may contribute to the ordering of late mitotic events by ensuring that mitotic exit is delayed until after anaphase is initiated. In addition, the stabilization of Pds1 after DNA damage provides a mechanism to delay both anaphase and mitotic exit while DNA repair occurs.  (+info)

Regulation of APC activity by phosphorylation and regulatory factors. (3/136)

Ubiquitin-dependent proteolysis of Cut2/Pds1 and Cyclin B is required for sister chromatid separation and exit from mitosis, respectively. Anaphase-promoting complex/cyclosome (APC) specifically ubiquitinates Cut2/Pds1 at metaphase-anaphase transition, and ubiquitinates Cyclin B in late mitosis and G1 phase. However, the exact regulatory mechanism of substrate-specific activation of mammalian APC with the right timing remains to be elucidated. We found that not only the binding of the activators Cdc20 and Cdh1 and the inhibitor Mad2 to APC, but also the phosphorylation of Cdc20 and Cdh1 by Cdc2-Cyclin B and that of APC by Polo-like kinase and cAMP-dependent protein kinase, regulate APC activity. The cooperation of the phosphorylation/dephosphorylation and the regulatory factors in regulation of APC activity may thus control the precise progression of mitosis.  (+info)

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. (4/136)

The anaphase-promoting complex/cyclosome (APC) is a tightly cell cycle-regulated ubiquitin-protein ligase that targets cyclin B and other destruction box-containing proteins for proteolysis at the end of mitosis and in G1. Recent work has shown that activation of the APC in mitosis depends on CDC20, whereas APC is maintained active in G1 via association with the CDC20-related protein CDH1. Here we show that the mitotic activator CDC20 is the only component of the APC ubiquitination pathway whose expression is restricted to proliferating cells, whereas the APC and CDH1 are also expressed in several mammalian tissues that predominantly contain differentiated cells, such as adult brain. Immunocytochemical analyses of cultured rat hippocampal neurons and of mouse and human brain sections indicate that the APC and CDH1 are ubiquitously expressed in the nuclei of postmitotic terminally differentiated neurons. The APC purified from brain contains all core subunits known from proliferating cells and is tightly associated with CDH1. Purified brain APC(CDH1) has a high cyclin B ubiquitination activity that depends less on the destruction box than on the activity of mitotic APC(CDC20). On the basis of these results, we propose that the functions of APC(CDH1) are not restricted to controlling cell-cycle progression but may include the ubiquitination of yet unidentified substrates in differentiated cells.  (+info)

The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. (5/136)

The cyclosome pathway of ubiquitin-mediated proteolysis plays an essential role in cell cycle control. The multisubunit cyclosome is regulated by transient interactions with Fizzy (Fzy) and Fizzy-related (Fzr) genes. We report here that both Fzy and Fzr are transcribed in a cell cycle specific but distinct manner. Fzy transcription starts after the restriction point in late G1 and ceases upon cell division. Fzr transcription also ceases upon cell division but resumes already in mid G1, before the restriction point, and takes place also in G0. Fzr has further a striking cell cycle specific pattern of mRNA stability. During most of the cell cycle its message is fairly stable, however upon exit from mitosis it is rapidly degraded. This result is puzzling because Fzr is essential for cyclosome activity in G1, and points to a complex pattern of Fzr regulation.  (+info)

Two different modes of cyclin clb2 proteolysis during mitosis in Saccharomyces cerevisiae. (6/136)

Sister chromatid separation and mitotic exit are triggered by the anaphase-promoting complex (APC/C) which is a multi-subunit ubiquitin ligase required for proteolytic degradation of various target proteins. Cdc20 and Cdh1 are substrate-specific activators of the APC/C. It was previously proposed that Cdh1 is essential for proteolysis of the yeast mitotic cyclin Clb2. We show that Clb2 proteolysis is triggered by two different modes during mitosis. A fraction of Clb2 is degraded during anaphase in the absence of Cdh1. However, a second fraction of Clb2 remains stable during anaphase and is degraded in a Cdh1-dependent manner as cells exit from mitosis. Most of cyclin Clb3 is degraded independently of Cdh1. Our data imply that degradation of mitotic cyclins is initiated by a Cdh1-independent mechanism.  (+info)

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. (7/136)

The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and specific. One key component of the degradation system, the anaphase promoting complex (APC), is a ubiquitin protein ligase. It is activated both during mitosis and late in mitosis/G(1), by the WD repeat proteins Cdc20 and Cdh1, respectively. These activators target distinct sets of substrates. Cdc20-APC requires a well-defined destruction box (D box), whereas Cdh1-APC confers a different and as yet unidentified specificity. We have determined the sequence specificity for Cdh1-APC using two assays, ubiquitination in a completely defined and purified system and degradation promoted by Cdh1-APC in Xenopus extracts. Cdc20 is itself a Cdh1-APC substrate. Vertebrate Cdc20 lacks a D box and therefore is recognized by Cdh1-APC through a different sequence. By analysis of Cdc20 as a substrate, we have identified a new recognition signal. This signal, composed of K-E-N, serves as a general targeting signal for Cdh1-APC. Like the D box, it is transposable to other proteins. Using the KEN box as a template, we have identified cell cycle genes Nek2 and B99 as additional Cdh1-APC substrates. Mutation in the KEN box stabilizes all three proteins against ubiquitination and degradation.  (+info)

Mitotic regulation of the APC activator proteins CDC20 and CDH1. (8/136)

The ordered activation of the ubiquitin protein ligase anaphase-promoting complex (APC) or cyclosome by CDC20 in metaphase and by CDH1 in telophase is essential for anaphase and for exit from mitosis, respectively. Here, we show that CDC20 can only bind to and activate the mitotically phosphorylated form of the Xenopus and the human APC in vitro. In contrast, the analysis of phosphorylated and nonphosphorylated forms of CDC20 suggests that CDC20 phosphorylation is neither sufficient nor required for APC activation. On the basis of these results and the observation that APC phosphorylation correlates with APC activation in vivo, we propose that mitotic APC phosphorylation is an important mechanism that controls the proper timing of APC(CDC20) activation. We further show that CDH1 is phosphorylated in vivo during S, G2, and M phase and that CDH1 levels fluctuate during the cell cycle. In vitro, phosphorylated CDH1 neither binds to nor activates the APC as efficiently as does nonphosphorylated CDH1. Nonphosphorylatable CDH1 mutants constitutively activate APC in vitro and in vivo, whereas mutants mimicking the phosphorylated form of CDH1 are constitutively inactive. These results suggest that mitotic kinases have antagonistic roles in regulating APC(CDC20) and APC(CDH1); the phosphorylation of APC subunits is required to allow APC activation by CDC20, whereas the phosphorylation of CDH1 prevents activation of the APC by CDH1. These mechanisms can explain the temporal order of APC activation by CDC20 and CDH1 and may help to ensure that exit from mitosis is not initiated before anaphase has occurred.  (+info)

*Cdc14

In that species, one important target is Cdh1/Hct1. Cdh1 associates with the APC and leads to APC activity (anaphase promoting ... "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22: 3524-3535. doi: ... Also, while the protein regulates the Cdk1 ortholog of S. pombe, this occurs through a process unlike that of S. cerevisiae; it ... Cdc14 and Cdc14 are a gene and its protein product respectively. Cdc14 is found in most of the eukaryotes. Cdc14 was defined by ...

*FBXO5

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene. This gene encodes a member of the F-box protein ... Cdh1)". Nat. Cell Biol. 4 (5): 358-66. doi:10.1038/ncb785. PMID 11988738. Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (2003). "[Effect of ... and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this ... The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box ...

*CDC20

A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle. CDC20 appears to act as a ... Cdc20 is a protein related to the beta subunit of heterotrimeric G proteins. Near its C-terminus it contains seven WD40 repeats ... Securin is a protein that inhibits separase, which in turn inhibits cohesin, a protein that holds sister chromatids together. ... Importantly, cyclin accumulation is also prevented by Cdh1. Cdc20-homologue 1 (Cdh1) plays a complementary role to Cdc20 in ...

*ANAPC7

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459-68. ... Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ...

*ANAPC4

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ... A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition ...

*ANAPC11

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol ...

*CDC16

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain ... This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ... Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene. ...

*ANAPC2

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol ...

*ANAPC10

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ...

*ANAPC5

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ...

*CKAP2

Seki A, Fang G (2007). "CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit". J. Biol. Chem. 282 ( ... Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene. GRCh38: Ensembl release 89: ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... "Entrez Gene: CKAP2 cytoskeleton associated protein 2". Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1 ...

*ANAPC1

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase- ... The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby ...

*FOXM1

... has been shown to interact with Cdh1. FOX proteins GRCh38: Ensembl release 89: ENSG00000111206 - Ensembl, May 2017 GRCm38 ... Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member ... FOXM1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Laoukili J, Alvarez-Fernandez M, Stahl M, Medema RH (Sep 2008). "FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner ...

*Anaphase-promoting complex

... there is still much to learn about how proteins are targeted by the APC/C. Once bound to APC/C, Cdc20 and Cdh1 serve as D and ... It is important to note that the conserved area of the propeller of Cdh1 is much larger than that of Cdc20, allowing Cdh1 to ... These TPR subunits, Cdc16, Cdc27, Cdc23, and Apc5, mainly provide scaffolding and support to mediate other protein-protein ... These proteins target the APC/C to specific sets of substrates at different times in the cell cycle, thus driving it forward. ...

*CDH3 (gene)

... has been shown to interact with: Beta-catenin, CDH1, Catenin (cadherin-associated protein), alpha 1, Nephrin and ... Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene. This gene is a classical ... The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a ... Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha ...

*CDC27

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins ... Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene. The protein encoded by this ... This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly ...

*CDC23

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... a protein domain important for protein-protein interaction. CDC23 has been shown to interact with CDC27. GRCh38: Ensembl ... This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly ... The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression ...

*Biochemical switches in the cell cycle

... a phosphatase that counteracts Cdk1 via activation of Cdh1 and Swi5, a transcriptional activator of Sic1 proteins. While ... promotes formation of APC in association with Cdh1 (APC-Cdh1) to degrade Clb2s. Cdc20 and Cdh1, which are the activators of APC ... This allows for the transcription of S phase genes encoding for proteins that amplify the G1 to S phase switch. Many different ... This action is controlled by the Esp1 protein, which is tightly bound by the anaphase inhibitor Pds1 that is destroyed by the ...

*Mitotic exit

... a phosphatase that counteracts Cdk1 via activation of Cdh1 and Swi5, a transcriptional activator of Sic1 proteins. While ... promotes formation of APC in association with Cdh1 (APC-Cdh1) to degrade Clb2s. Cdc20 and Cdh1, which are the activators of APC ... The double-negative feedback loop, formed by APC-Cdh1 and Sic1, is required to maintain low Clb2-Cdk1 activity because Clb2 ... Without Cdk1-Clb2 complexes to phosphorylate proteins that are involved in spindle dynamics such as Sli15, Ase1, and Ask1, ...

*NEDD9

... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ... CDH1 subunit of the APC complex recognizes NEDD9 and regulates ubiquitination and subsequent degradation of NEDD9. NEDD9 is ... Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the ... NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction ...

*Clb 5,6 (Cdk1)

It is hypothesized that Clb5 and Clb6 are somewhat resistant to APC-Cdh1 degradation since they are primarily regulated by APC- ... Clb5, in particular, has unique hydrophobic section of amino acids that allows specific interactions with proteins in the pre- ... Finally, Clb5-Cdk1 has been shown to be important for the phosphorylation of Cdh1 in yeast, and Clb5 destruction promotes ... An important regulatory event during G1 is the inactivation of the anaphase promoting complex (APC-Cdh1). Clb5 and Clb6 ...

*FZR1

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... Fizzy-related protein homolog is a protein that in humans is encoded by the FZR1 gene. FZR1 has been shown to interact with ... 2005). "Mammalian Cdh1/Fzr mediates its own degradation". EMBO J. 23 (7): 1619-1626. doi:10.1038/sj.emboj.7600149. PMC 391060 ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337-345. doi: ...

*SCF complex

Two F-box-protein-bound SCF complexes (SCF-Skp2 and SCF-β-TrCP), are most well studied among over 70 F-box proteins identified ... On the other hand, SCF-βTrCP promotes proteolysis of Emi1, an APC/C-Cdh1 inhibitor, and Wee1, a Cdk1 inhibitor, in early ... The TIR1 F-box protein acts as an auxin receptor and directly links reception of auxin to degradation of the Aux/IAA proteins. ... Instead, F-box affinity for protein substrates is regulated through cdk/cyclin mediated phosphorylation of target proteins.[ ...

*Plakoglobin

Swope D, Cheng L, Gao E, Li J, Radice GL (Mar 2012). "Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart ... Plakoglobin has been shown to interact with: APC, CTNNA1, CTNNB1, CDH1, CDH2, CDH3, CDH5, DSG2, DSP, MUC1, PKP2, PTPkappa ( ... Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. ... Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P (Mar 1995). "The APC protein and E-cadherin form similar but independent ...

*CDH16

... the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain ... Cadherin-16 is a protein that in humans is encoded by the CDH16 gene. This gene is a member of the cadherin superfamily, genes ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation ...

*Proteasome

The protein degradation processEdit. Ribbon diagram of ubiquitin, the highly conserved protein that serves as a molecular tag ... Cdh1) ubiquitin ligase". Nature. 428 (6979): 190-3. doi:10.1038/nature02330. PMID 15014502.. ... Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks ... Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ...
Prophase I arrest, referred to as the germinal vesicle (GV) stage, is a conserved feature of oocytes across species (Whitaker, 1996; Mehlmann, 2005; Jones, 2008). In mice, as in all mammals, GV arrest begins shortly after meiotic recombination in fetal life. Periodic, non-hormonal recruitment of a small number of quiescent follicles into the growing pool after birth leads to follicle growth and eventual ovulation, both of which are hormone dependent. It is only near the time of ovulation in the fully grown oocytes of mature follicles that a rise in luteinizing hormone (LH) breaks this arrest, causing GV breakdown (GVB).. A high level of cAMP, generated from a Gs-coupled oocyte receptor, is needed to maintain arrest in fully grown oocytes (Cho et al., 1974; Magnusson and Hillensjo, 1977; Bornslaeger et al., 1986; Mehlmann et al., 2002; Freudzon et al., 2005). This is enhanced by cGMP from the surrounding cumulus cells, which inhibits phosphodiesterase 3A (PDE3A) activity, preventing cAMP ...
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated
Figure 1. Cdh1 phosphorylation at Cdk sites promotes Cdh1 stability. A, Schematic of nine conserved sites of potential Cdk phosphorylation in Cdh1 (S/T-P), numbered according to human Cdh1. B, Lysates of 293T cells transfected with GFP-Cdh1 WT, 9A, or 9D were immunoblotted using a polyclonal antibody to Cdh1 or Erk, the latter to serve as a loading control. Quantitation of Cdh1 levels normalized by Erk revealed that the levels of the 9D and 9A mutant proteins were, respectively, increased by 122% and reduced by 57% relative to wild-type Cdh1 in 293T cells (average of 4 experiments). C, Lysates of Neuro2A cells transfected with GFP-Cdh1 WT, 9A, or 9D and treated with MG132 (5 μm) or the vehicle control DMSO were immunoblotted for GFP or Erk. The levels of the 9D and 9A mutant proteins were, respectively, increased by 150% and reduced by 37% relative to wild-type Cdh1 in Neuro2A cells (average of 2 experiments). MG132 treatment, respectively, increased WT, 9A, and 9D levels by 80, 134, and 9%. D, ...
CDH23 - CDH23 (untagged)-Human cadherin-related 23 (CDH23) transcript variant 3 available for purchase from OriGene - Your Gene Company.
Rational: Poor prognosis epithelial-derived cancers often exhibit morphologic and molecular changes characteristic of an epithelial to mesenchymal transition (EMT). EMT markers are predominantly found in tumors with a basal-like phenotype. Increased expression of the mesenchymal cadherins N-cadherin and/or Cadherin-11 (CDH11) and decreased E-cadherin, have been associated with both EMT and tumor progression. Importantly, CDH11 is a therapeutic target in rheumatoid arthritis (RA), an inflammatory disease with properties often compared with cancer. As CDH11 antibody based therapeutics are in clinical trials for RA and we recently showed that the arthritis drug celecoxib has the structural potential to bind CDH11, there is a strong possibility that, if CDH11can be shown to drive malignant progression rather than simply be associated with it, therapeutic options may be rapidly developed.. Results: We show that CDH11 is increased early in breast cancer and ductal carcinoma in-situ. CDH11 knockdown ...
CHO-Anti-Human CDH17 MAb stable cell line is clonally-derived from a CHO cell line, which has been transfected with an Anti-human CDH17 MAb gene to allow expression of the MAb. It is an example of a cell line transfected using our proprietary CBTGS gene screening and amplification system.
Complete information for CDH11 gene (Protein Coding), Cadherin 11, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Monoclonal antibody against Cadherin, E- expressed by Cdh1 for use in FFPE, Function Blocking, Immunofluorescence, Immunoprecipitation, Western Blot against Drosophila, Xenopus
####### Forum Help ####### Forum Rules I need to contact Jim Humble Contact jimhumble.is/contact The MMS Protocols Youll find them at the...
Liver cancer is the fifth most commonly diagnosed and the second most lethal malignancies worldwide, in which hepatocellular carcinoma (HCC) represents the majority subtype. High mortality rate of HCC is due to lack of effective treatments and early detection methods. Activation of cadherin-17 (CDH17)/β-catenin axis is found by our team in HCC and targeting components of this axis associated with anti-tumorigenesis. With limited knowledge on this axis in HCC, I plan to study molecules related to this axis as a way to uncover the cellular mechanism of this axis in liver tumorigenesis. Gene profiling data was re-analyzed to search for CDH17-associated genes in HCC clinical samples. The patient cohort was segregated into CDH17-high and CDH17-low group according to tumor/adjacent non-tumor expression ratio of CDH17. Serine peptidase inhibitor, Kazal type 1 (SPINK1) was found highly expressed in CDH17-high cases and its over-expression accounted for 73 % of total studied cases. Gene manipulation and ...
Overexpression of mitotic cyclin CLB2 results in premature spindle elongation in swe1Δ mutants.A. Overexpression of CLB2 is toxic to swe1Δ mutants. WT and swe
Organ morphogenesis in multicellular organisms relies on the coordinated progression of cell proliferation and cell growth. Compared with animals, plants often undergo far more extensive post‐mitotic cell growth, sometimes up to 1000‐fold of original size, and an increase in cell size generally contributes to a larger extent to organ growth. It is also known that some cell types, such as neurons and various hair cells in insects, animals and plants, undergo massive cell growth during differentiation and this is vital for their specialised physiology and function (Sugimoto‐Shirasu and Roberts, 2003). Since the final size of cells is often fairly constant under given conditions, the duration of post‐mitotic cell growth is likely to be developmentally programmed. We still know surprisingly little about how cell size is determined and how developmental signals link to this control. Most of loss‐of‐function mutants with developmental defects display reduced cell‐size phenotypes, ...
Full-length coding sequences of two novel human cadherin cDNAs were obtained by sequence analysis of several EST clones and 5 and 3 rapid amplification of cDNA ends (RACE) products. Exons for a third cDNA sequence were identified in a public-domain
CDH1 - human gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN220731G1|/strong|, CDH1 gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.
As a guild, our mission is to raise money for Seattle Childrens Hospital. But we are also a group of parents, friends and family - all touched in some way by CDH. And as such, we seek to raise awareness of this life-threatening birth defect so that we may inspire hope and empowerment for those…
Order CDH6 ELISA Kits for many Reactivities. Chicken, Cow, Human and more. Compare CDH6 ELISA Kits and find the right product on antibodies-online.com.
Complete information for CDH12P1 gene (Pseudogene), Cadherin 12 Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Mouse monoclonal antibody raised against a partial recombinant CDH2. CDH2 (NP_001783, 807 a.a. ~ 906 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00001000-M10) - Products - Abnova
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Expression of CDH3 (CDHP, PCAD) in human tissue. Overview of the antibody staining with HPA001767 and CAB002487 in immunohistochemistry
Summary of CDH13 (CDHH) expression in human tissue. Distinct membranous and cytoplasmic expression in muscle tissues, renal glomeruli, cerebral cortex, in endothelial cells and in basal cells of squamous epithelia.
Human FZR1 full-length ORF ( AAH13413.1, 1 a.a. - 493 a.a.) recombinant protein with GST-tag at N-terminal. (H00051343-P01) - Products - Abnova
A couple of months ago, I started going to GriefShare classes (which are ran out of local churches all over the US. I highly recommend it!). I decided to go because I felt like life was going on as normal but I knew everything wasnt normal. It may have been because I spend a majority of my time at home with the kids and there wasnt the emotional room to grieve everyday and also care for the kids. I wasnt able to be available (or present) to them...so I decided I needed to set aside time for Noa, and thus, the classes. It has been so good. Its help put parameters on what Im experiencing and how it might be different in the light of our situation. It also has given some makers of growth and typical areas people might get stuck. And they just do a good job of covering many areas a grieving person will encounter. The first class I went to dealt with how family members grieve differently...and it brought deeper assurance that Justin not attending the class with me was ok...even good. And ...
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Discover Lifes page about the biology, natural history, ecology, identification and distribution of Childs, Ken I_KEN/0002 -- Discover Life
Lala Kent has always been candid about her struggles with substance abuse, but last month she opened up about her struggle with alcoholism -what shes doing about it. Five months ago, I came to the realization that I am an alcoholic, and I am now a friend of Bill W., Kent said on Instagram. In an interview with
人乳腺癌体细胞突变PCR芯片适用于快速、准确的检测和研究乳腺癌的常见基因突变,包括:AKT1, APC, BRAF, CDH1, CTNNB1, HRAS, NRAS, KRAS, PIK3CA和TP53。对上述基因突变的深入研究有助于科研工作者更好的
Ad Age Editor Ken Wheaton writes that pharmaceutical marketers might end up on the wrong end of regulation if they dont rein in their excesses.
Know Can Do! Put Your Know-How Into Action - читать онлайн бесплатно без регистрации, Ken Blanchard. Электронная библиотека КучаКниг.
Introduction Down-regulation of E-cadherin (CDH1) and epithelial-mesenchymal transition (EMT) are considered critical events for invasion and metastasis of colorectal carcinoma. Here we tested whether the important regulators of E-cadherin expression SNAI1 and TWIST1 are already detectable in human colorectal adenomas. Methods RNA was extracted from a set of randomly selected formalin-fixed and paraffin-embedded (FFPE) colorectal adenomas (n = 41) and normal colon mucosa (n = 10). Subsequently mRNA expression of CDH1, CDH2, SNAI1 and TWIST1 was analysed by quantitative RT-PCR analysis. CDH1 as well as SNAI1 protein expression were assessed by immunohistochemistry (IHC). Results SNAI1 mRNA was expressed in 78% (n = 32/41), TWIST1 mRNA in 41% (n = 17/41) and CDH2 mRNA in 41% (n = 17/41) of the colorectal adenoma tissue, while normal colon mucosa was negative for these transcription factors. We found a significant correlation between reduced CDH1 and the presence of SNAI1 mRNA expression and for
Looking for online definition of CDH5 in the Medical Dictionary? CDH5 explanation free. What is CDH5? Meaning of CDH5 medical term. What does CDH5 mean?
Looking for online definition of CDH13 in the Medical Dictionary? CDH13 explanation free. What is CDH13? Meaning of CDH13 medical term. What does CDH13 mean?
CDH1 research is a relatively new area in certain respects. In 1999, a medical researcher in New Zealand named Dr. Parry Guilford and his colleagues discovered the connection between CDH1 mutations and cancers of the stomach and breasts. Despite it being a relatively recent discovery, searching for information about CDH1 research returns a lot of information.. Using publicly available information, I am researching the landscape of research on issues relating to CDH1 mutation carriers. Typically, when doing this kind of work in the past, I have used Google Scholar and the United States Patent Office patent and patent application databases. Those are great resources for learning more about research in many areas of medical research. Using those tools to do some preliminary searching about CDH1 issues, it seems that researchers are searching for ways to improve methods for detecting early signs of diffuse stomach cancer and lobular breast cancer. Also, they are exploring drug development and other ...
Germline mutations in the CDH1 (E-cadherin gene) gene have been reported in families with a hereditary predisposition to breast cancer and gastric cancer. Sequencing and deletion/duplication analyses of the CDH1 gene will identify individuals at risk for CHD1-related cancers ...
Prenatal therapy to stimulate lung growth. The critical point in fetuses diagnosed with CDH is not the defect in their diaphragm, but the lung volume available at birth. Indeed, when inside the womb, the baby gets its oxygen from the mother through the placenta. At birth however, a baby needs his/her own lungs to breathe and to provide sufficient oxygen to the other organs. Although the human lung can still grow a lot after birth, its size might not be enough to provide sufficient oxygen uptake in the first few days of life. Therefore, intensive neonatal care might for some babies not be enough to help them survive. As a consequence, if one would like to improve the prognosis for these very severe cases of CDH, one would need to do something before birth to improve lung growth and to provide these babies with a better start.. For more than 25 years researchers have been exploring this path. Initially they tried to provide space for the developing lung in the way it is done after birth: surgeons ...
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The ACM India Council is an effort of ACM aimed at increasing the level and visibility of ACM activities across India. The ACM community in India is growing in membership, number of chapters, sponsored conferences and symposia.. The ACM India Council comprises a cross section of the computer science and information technology community committed to increasing the visibility and relevance of ACM in India. The council is focused on a wide range of ACM activities including:. ...
Polyclonal antibody for VE CADHERIN/CDH5 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. VE CADHERIN/CDH5 information: Molecular Weight: 87528 MW; Subcellular Localization: Cell junction . Cell membrane ; Sin
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
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Organ Nakli Merkezi, Tüp Bebek Merkezi, Havacılık Tıp Merkezi, Uyku bozuklukları Merkezi, Sigarayı bıraktırma merkezi, Poliklinik Hizmetleri ile 295 yataklı Başkent Üniversitesi Hastanesinde ve hastaneye bağlı, 90 yataklı Ayaş Fizik Tedavi ve Rehabilitasyon Merkezi ve 65 yataklı Yapracık Psiko-Sosyal Rehabilitasyon Merkezi gibi kuruluşları ile hizmetinizde..
IDCore 30 rev B is a highly secured smartcard platform compliant with Javacard 2.2.2, Global Platform 2.1.1 & 2.2 Amendment D standards, designed to operate with Infineon SLE78 chip family. The library implements TDEA, AES, AES-CMAC, SHA1-224-256-384-512, RSA, RSA CRT, ECDSA, ECC CDH, SP800-108 KDF and SP800-90A DRBG ...
Kent Larson directs the City Science (formerly Changing Places) group at the MIT Media Lab. His research focuses on developing urban interventions that enabl...
There is an approval process which can take up to 48 hours so make sure to fill out your form thoroughly to speed up the process. All information is 100% confidential and is not given or sold to anyone or any other group or business. We value our members privacy and safety, which is why we verify each new member. Information on your membership form is also used for CDH Research so you not only get wonderful information and support but you help CDH research as well ...
Hi- Our daughter is a 15 year old right-sided cdh survivor. I would love to know if there are any more right-sided teenage survivors out there. Our daughter has developed scoliosis during her teenage growth spurt, and we are facing spinal fusion surgery. I am very concerned about this surgery. I would love to hear from someone with a teenage cdh child who has had a spinal fusion. Thanks!
As a major regulator of EMT, ZEB1 is capable of acting as either a transcriptional activator or repressor and aberrant expression of ZEB1 is associated with tumorigenesis and disease.19,37-40 During EMT, the expression of CDH1, a classic epithelial marker that is involved in cell-cell adhesion and in the maintenance of apicobasal polarity, is repressed by ZEB1 via its binding to two E2 box motifs in the CDH1 promoter region.29,30 Although altered ZEB1 levels have been shown to affect CDH1 expression, we have demonstrated that the CDH1 transcript is not present in ex vivo human corneal endothelial cells (and presumably also absent in in vivo endothelium).41-43 Therefore, ZEB1 haploinsufficiency likely results in changes in the expression of other genes that are the direct targets of ZEB1 in the corneal endothelium. Although it has not yet been definitively determined which of these differentially expressed genes are involved in the pathogenesis of PPCD, altered expression of type IV collagens, ...
The Journey of having a baby with Congenital Diaphragmatic Hernia (CDH), the doctor (Kays) who has a passion for them, and how our Lord is bringing us through this experience.
The Journey of having a baby with Congenital Diaphragmatic Hernia (CDH), the doctor (Kays) who has a passion for them, and how our Lord is bringing us through this experience.
We woke up this morning with a bit of a start: when we called in to check on our boy, we found out hed had a very stable night. That wasnt the scary part. Then, we were told that there was the possibility that today was the day his ECMO circuit would be changed. Basically, a given circuit (tubing) of ECMO has a set lifespan that is dependent on the person receiving it, as well as the mechanical fortitude of its parts. When there is an increase in clotting that cant be managed with medication, the conversation begins about replacing the circuit. While this is a routine procedure, anything that directly affects your baby is automatically not routine. One of our lovely nurses, Tracey, shared this news with us and then directed us to the Great Ken, our lovable and quirky ECMO technician (weve had others, but hes our fave). After explaining the nature of the process, he proceeded to tell us that Rafa has done "remarkably well" tolerating his circuit for "this long ...
We woke up this morning with a bit of a start: when we called in to check on our boy, we found out hed had a very stable night. That wasnt the scary part. Then, we were told that there was the possibility that today was the day his ECMO circuit would be changed. Basically, a given circuit (tubing) of ECMO has a set lifespan that is dependent on the person receiving it, as well as the mechanical fortitude of its parts. When there is an increase in clotting that cant be managed with medication, the conversation begins about replacing the circuit. While this is a routine procedure, anything that directly affects your baby is automatically not routine. One of our lovely nurses, Tracey, shared this news with us and then directed us to the Great Ken, our lovable and quirky ECMO technician (weve had others, but hes our fave). After explaining the nature of the process, he proceeded to tell us that Rafa has done "remarkably well" tolerating his circuit for "this long ...
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Weve been so excited over the last few days because the Lord provided a way for Jude to come off of ECMO safely and he has remained mostly stable since. However, after experiencing several positive days we are beginning to face the reality again: Judes life is still at risk. CDH is a very serious condition and Judes battle is likely not even halfway done. He has yet to have his repair surgery and the days/weeks after Judes surgery are the some of the most critical. We simply have to wait and see what Judes lungs and heart are capable of. We are so anxious for Jude to have his CDH repair surgery but we are also so nervous about how his little body will perform afterwards. Will you join us in praying NOW for his little body to be prepared for the big push after his repair? We dont know yet when his surgery will take place but we know that the Lord is faithful and that his plan for Jude and our family is good. We are truly resting and trusting in that ...
The Author. In a world of informational overload, an informational guide is only as good as its author. As such, it is a worthwhile endeavor to help you understand the brain behind this particular guide.. Diseaseless is a product of Ken Drew. Kens background was punctuated with illnesses of all manner, from simple colds and flu to more serious diseases.. By the time he was 40, Kens appearance resembled that of a 60 year old man. Due to constant illness, Ken wasnt able to look after his family because he couldnt work.. Ken decided that enough was enough and he decided to take matters of his health in his own hands. Through some grueling research and hundreds of trials, he finally came up with a series of treatment options that could not only clear many illnesses but also prevent them.. Ken decided to compile these treatment options into one digital guide called Diseaseless. Everything in the guide has been used and tested by him. He managed to revitalize his health and rid his body of all ...
Afters months of waiting, I have finally been able to get my act together enough to post the answers to questions you posed to |a href=http://www.science.oregonstate.edu/~kentad/|Dr. Adam Kent|/a|. If you remember back to |a href=http://bigthink.com/ideas/24029|the beginning of the fall|/a|, Dr. Kent and his colleagues published a paper in |em|Nature Geosciences|/em| about the |a href=http://www.nature.com/ngeo/journal/v3/n9/abs/ngeo924.html|nature of magma mixing|/a| and ...
Frequently overexpressed genes (tumor/normal ratio > 2) were COL1A1 (percentage of cases with overexpression, 78.3%), CDH17 (73.9%), APOC1 (67.4%), COL1A2 (58.7%), YF13H12 (52.2%), CEACAM6 (50.0%), APOE (50.0%), REGIV (47.8%), S100A11 (41.3%), and FUS (41 ...
So Ken Ham wont debate Aron Ra and PZ Myers because... reasons! He complained that the debate invitation was rude, but look how rude he was to Bill Nye...
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On the evening of October 14, 2017, Lesley Rebeca Parrott passed away surrounded by family. She was born January 9, 1989, in Kent, WA to Craig and Anna (Wright) Parrott.
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This study was designed to investigate the DNA-methylation status of E-cadherin (CDH1) and H-cadherin (CDH13) in serum samples of cervical cancer patients and control patients with no malignant diseases and to evaluate the clinical utility of these markers. DNA-methylation status of CDH1 and CDH13 was analyzed by means of MethyLight-technology in serum samples from 49 cervical cancer patients and 40 patients with diseases other than cancer. To compare this methylation analysis with another technique, we analyzed the samples with a denaturing high performance liquid chromatography (DHPLC) PCR-method. The specificity and sensitivity of CDH1 DNA-methylation measured by MethyLight was 75% and 55%, and for CDH13 DNA-methylation 95% and 10%. We identified a specificity of 92.5% and a sensitivity of only 27% for the CDH1 DHPLC-PCR analysis. Multivariate analysis showed that serum CDH1 methylation-positive patients had a 7.8-fold risk for death (95% CI: 2.2-27.7; p = 0.001) and a 92.8-fold risk for relapse (95%
The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase with essential functions in mitosis, meiosis, and G1 phase of the cell cycle. APC/C recognizes substrates via coactivator proteins such as Cdh1, and bound substrates are ubiquitinated by E2 enzymes that interact with a hetero-dimer of the RING subunit Apc11 and the cullin Apc2. We have obtained three-dimensional (3D) models of human and Xenopus APC/C by angular reconstitution and random conical tilt (RCT) analyses of negatively stained cryo-electron microscopy (cryo-EM) preparations, have determined the masses of these particles by scanning transmission electron microscopy (STEM), and have mapped the locations of Cdh1 and Apc2. These proteins are located on the same side of the asymmetric APC/C, implying that this is where substrates are ubiquitinated. We have further identified a large flexible domain in APC/C that adopts a different orientation upon Cdh1 binding. Cdh1 may thus activate APC/C both by recruiting substrates ...
CDC6 is conserved during evolution and is essential and limiting for the initiation of eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and CDK-regulated subcellular localization. Here, we show that, in addition to being absent from nonproliferating cells, CDC6 is targeted for ubiquitin-mediated proteolysis by the anaphase promoting complex (APC)/cyclosome in G(1). A combination of point mutations in the destruction box and KEN-box motifs in CDC6 stabilizes the protein in G(1) and in quiescent cells. Furthermore, APC, in association with CDH1, ubiquitinates CDC6 in vitro, and both APC and CDH1 are required and limiting for CDC6 proteolysis in vivo. Although a stable mutant of CDC6 is biologically active, overexpression of this mutant or wild-type CDC6 is not sufficient to induce multiple rounds of DNA replication in the same cell cycle. The APC-CDH1-dependent proteolysis of CDC6 in early G(1) and in quiescent cells suggests that this process is part of a ...
The Anaphase promoting complex/ cyclosome (APC/C) is a 1.2 MDa multi-subunit E3 ubiquitin ligase that encodes broad substrate-specificity via its two co-activators Cdc20 and Cdh1 and three principal degrons: the D-box, KEN box and ABBA motif. The regulation of mitotic exit is tightly controlled by the expression and degradation of these two co-activators through stages of the cell cycle. The upregulation of Cdc20 is associated with many cancers including pancreatic, breast and cervical cancers and hepatocellular carcinomas. However, to date, no specific inhibitors of the APC/CCdc20 exist in the clinic. Only two APC/C specific compounds have been discovered: TAME/pro-TAME, which disrupts the C-terminal IR tail of Cdc20 binding to APC3, and Apcin, which disrupts substrate D-box degron binding to Cdc20. Recent studies have highlighted the need for a combination strategy to achieve full inhibition of the APC/CCdc20. We propose a new approach involving the design of constrained peptides to inhibit ...
CDH Australia is run solely by volunteers and relies heavily on donations.. All donations over $2.00 are tax deductible and can be made in honour or memory of individual CDH children.. Donate Today. ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011 ...
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|i|Cre|/i| expression in these transgenic mice can be seen in the embryo and in adult endothelium of developing and quiescent vessels, as well as in a subset of hematopoietic cells. When bred with mice carrying a |i|loxP|/i|-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system.
Im on 10mg of prednisone per day for my asthma. Ive recently started mms and when taking a full blood count test, it showed unsuppressed. Could mms cause...
KENT CITY, Michigan. -- Emergency crews responded to a minor ammonia leak on a farm Tuesday at 3509 18-Mile road in Kent City. According to the Kent County Sheriffs department the leak was reported shortly before 10:30 in the morning.
Here is the best resource for homework help with STA 2500 : Statistical Analysis at Kent State. Find STA2500 study guides, notes, and practice tests from Kent
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acm之pku题目分类 对ACM有兴趣的同学们可以看看 DP: 1011 NTA 简单题 1013 Great Equipment 简单题 1024 Calendar Game 简单题 1027 Human Gene Functions 简单题 1037 Gridland
Affiliation:浜松医科大学,医学部,特任研究員, Research Field:Experimental pathology,Tumor biology, Keywords:家族性胃がん,E-カドヘリン,生殖細胞系列変異,DNAメチル化,MLPA法,コピー数異常,変異,コピー数変化,CDH1,網羅的遺伝子発現解析, # of Research Projects:2, # of Research Products:17, Ongoing Project:網羅的染色体コピー数解析による家族性・若年性胃がんの新規原因遺伝子の探索
COMMUNIQUE DE PRESSE à ne pas manquer ! La campagne de Jean-Christophe Parisot prend un nouveau rythme . Celui qui défend les couleurs de la "force citoyenne et handicapée" dans le cadre de lélection présidentielle va vous permettre de mieux le connaître et surtout de mieux apprécier son environnement et son action dans cette période où toutes les énergies sont utiles . Un reportage le concernant sera diffusée ce mardi 12 décembre sur France 3 (national) au cours du 19/20 . Soyez nombreux devant vos téléviseurs et parlez-en .. Le candidat présenté par le Collectif des Démocrates Handicapés (CDH) compte bien mobiliser les humanistes au delà des formations traditionnelles .. www.force-citoyenne2007.com. Pour Information Immédiate : ...
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Brendon W. Kent is the author of this article in the Journal of Visualized Experiments: Zemin Projeksiyon Maze kullanma Kayıt Sinir Aktivitesi otomatik Görsel Bilişsel Görevler
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A congenital diaphragmatic hernia (CDH) is an early developmental defect that results in the extrusion of intraabdominal organs (ie. stomach, small intestines, kidney, liver) into the thoracic cavity. This defect can be isolated or associated with multiple congenital abnormalities with cardiac anomalies being the most common. Ninety-percent of CDH are located in the posterolateral diaphragm (Bochdaleks hernia), 3/4 of which are left sided. Physiologic consequences of CDH include lung hypoplasia, pulmonary hypertension, and pulmonary arteriolar dysregulation/reactivity (Davis, et al). Historically, CDH was considered a surgical emergency. It was approached using aggressive hyperventilatory strategies with the goal of obtaining pulmonary vasodilation through hyperoxia and respiratory alkalosis. This strategy often used high peak inspiratory pressures, ventilatory frequency, and oxygen concentration. This tactic was eventually abandoned after further research stressed the harmful effects of large ...
BRAF drives tumorigenesis by coordinating the activation of the RAS/RAF/MEK/ERK oncogenic signaling cascade. However, upstream pathways governing BRAF kinase activity and protein stability remain undefined. Here, we report that in primary cells with active APCFZR1, APCFZR1 earmarks BRAF for ubiquitination-mediated proteolysis, whereas in cancer cells with APC-free FZR1, FZR1 suppresses BRAF through disrupting BRAF dimerization. Moreover, we identified FZR1 as a direct target of ERK and CYCLIN D1/CDK4 kinases. Phosphorylation of FZR1 inhibits APCFZR1, leading to elevation of a cohort of oncogenic APCFZR1 substrates to facilitate melanomagenesis. Importantly, CDK4 and/or BRAF/MEK inhibitors restore APCFZR1 E3 ligase activity, which might be critical for their clinical effects. Furthermore, FZR1 depletion cooperates with AKT hyperactivation to transform primary melanocytes, whereas genetic ablation of Fzr1 synergizes with Pten loss, leading to aberrant coactivation of BRAF/ERK and AKT signaling in ...
Bladder cancers have a large range of variant morphologies, and tumors with wholly variant histologies exhibit worse survival rates. Variant histology bladder cancers were not included in The Cancer Genome Atlas (TCGA), and, thus, the molecular events underlying these tumors remain poorly understood. Al-Ahmadie, Iyer, Lee, and colleagues used whole-exome and targeted sequencing to characterize plasmacytoid bladder cancer, an aggressive histologic variant cancer. Whole-exome sequencing of six plasmacytoid variant bladder tumors revealed truncating somatic mutations in cadherin 1 (CDH1), which encodes E-cadherin, in all of the tumors, whereas there were no CDH1-truncating mutations in the 127 bladder cancers in TCGA. The frequency of CDH1 mutations in plasmacytoid variant bladder cancer was further validated by targeted sequencing in an additional 19 tumors, with 74% containing CDH1 mutations. Aside from CDH1 mutations, the genomic profile of plasmacytoid variant tumors was similar to other ...
The Kent Tribune. i - LOCAL LEADER IN BOTH NEWS AND CIRCULATION. War Savings Stamps are a Wise Investment. Early Christmas Shopping Helps Everybody. VOLUME III. NO. 50 KENT, OHIO, THURSDAY MORNING, OCT. 24, 1918 5c A COPY, $1.50 A YEAR Taught Thirty Successive Years. Death, of Mrs. Adda Garrison, Beloved and Successful Instructor in the Kent Schools. MRS. ADDA GARRISON. Mrs. Adda Garrison, who had devoted the greater part of her life- to the training of young lives, her work reaching to the children of her early pupils, passed away at 8 oclock Monday evening. Mrs. Garrison was a teacher greatly loved for her kindness and painstaking work, not only by her pupils but also by their parents and friends. She possessed the traits that enabled her to get the best results with corresponding benefits . to . the pupils, Discipline was easy for her. Her pupils loved her and took a real in terest in the work under her devotion and guidance. For thirty consecutive years she taught in. the schools of Kent. ...
... Ken was a chef before a motorbike crash turned his life upside down Ken was a chef before a motorbike crash turned his life upside down in 2001.Ken suffered horrific injuries, including muscle spasticity. It stopped my chefing career and I was lost because Id
Kara has been a member of CHERUBS since 2007 and has served on the CHERUBS Executive Board of Directors and Conference Planning Committee. She is wife to Chuck and is a stay at home mother of two busy boys. Prior to motherhood, Kara worked as a Senior Contracts Specialist for a meeting and conference planning company. She also worked as a Professional Development Assistant for a child care referral agency. Kara received her Associate of Applied Business degree from Stark State College. ...
PZ Myers,. Recently, while researching items for Dr. Kent Hovind, I happened to stumble across your many mean-spirited attacks against him. I read on as you and your minions showed yourselves to be as the apes you claim to descend from (probably your best evidence for evolution). Since you, and most of your ape-like readers, have no point of reference for justifying morality within yourselves, you should be notified that your behavior is downright shameful.. Anyway, I have been informed by Kent Hovind personally that he is ready at any time to consider your best evidence for evolution (in writing). Further, since you have zero capacity to understand even the smallest of spiritual concepts, he is ready to also present empirical evidence in rebuttal to support his position.. While you excel at insult and insensitivity, we wonder how much actual empirical evidence feeds this pompous attitude of yours. For years evolutionists have desired to get Kent Hovind into an "email debate" and he always ...
Originally posted @allaboutestates.ca On Wednesday, September 27th, Ken Chung, a 39 year old academic Philosopher died of Stage IV Pancreatic Cancer. Diagnosed in March 2016, Ken blogged about his experience up until his very last days, providing a unique and important perspective
Note: Running Services Use the service command to start, stop, and restart CDH components, rather than running scripts in /etc/init.d directly. The service command creates a predictable environment by setting the current working directory to / and removing most environment variables (passing only ...
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Vigilante attack threats have prompted Madame Tussauds to hide a waxwork of Coronation Street character Ken Barlow following actor Bill Roaches rape arrest.
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CDC27 is a core component of the anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, whose oscillatory activity is responsible for the metaphase-to-anaphase transition and mitotic exit. Here, in normal murine mammary gland epithelial cells (NMuMG), CDC27 expression is controlled posttranscriptionally through the RNA binding protein poly(rC) binding protein 1 (PCBP1)/heterogeneous nuclear ribonucleoprotein E1 (HNRNP E1). shRNA-mediated knockdown of HNRNP E1 abrogates translational silencing of the Cdc27 transcript, resulting in constitutive expression of CDC27. Dysregulated expression of CDC27 leads to premature activation of the G2-M-APC/C-CDC20 complex, resulting in the aberrant degradation of FZR1/CDH1, a cofactor of the G1 and late G2-M-APC/C and a substrate normally reserved for the SCF-βTRCP ligase. Loss of CDH1 expression and of APC/C-CDH1 activity, upon constitutive expression of CDC27, results in mitotic aberrations and aneuploidy in NMuMG cells. ...
E-cadherin (epithelial cadherin, CDH1, OMIM# 192090) is a member of the cadherin family of adhesion molecules, which are transmembrane glycoproteins mediating calcium-dependent cell-cell adhesion1. Germline mutations in the CDH1 gene have been demonstrated to underlie in diffuse gastric cancer (DGC) in various ethnic backgrounds 2, 3, 4. CDH1 germ line mutations have also been identified in a small portion of early onset DGC patients without a family history 5, 6, 12. Associations between CDH1 germ line mutations and both lobular breast cancer and signet ring carcinoma of the colon have been reported in DGC families 7, 8, 9. DGC is a highly penetrant autosomal dominant disorder that has been reported to occur in many ethnicities. The offspring of an affected individual has a 50% risk of also being affected. The estimated cumulative risk of gastric cancer by age 80 years is 67% (95% CI: 39-99) for men and 83% (95% CI: 58-99) for women10. Women also have a 39% risk for lobular breast cancer10. ...
The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established clinical impact, in about 20% of cases the mutations are of the missense type. The latter are of particular concern in terms of genetic counselling and clinical management, as the effect of the sequence variants in E-cadherin function is not predictable. If a deleterious variant is identified, prophylactic surgery could be recommended. Therefore, over the last few years, intensive research has focused on evaluating the functional consequences of CDH1 missense variants and in assessing E-cadherin pathogenicity. In that context, our group has contributed to better characterize CDH1 germline missense variants and is now considered a worldwide reference centre. In this review, we highlight the
To determine whether Trim39 could inhibit the APC/C, we added either maltose-binding protein (MBP) or MBP-Trim39 protein to lysates prepared from HeLa cells that had been synchronized in nocodazole and then released (by washout of the nocodazole). As shown in Fig. 1 C, cyclin B1 was quickly degraded in the presence of recombinant MBP protein as these lysates exited from the mitotic arrest, whereas degradation of endogenous cyclin B1 was nearly abolished by addition of recombinant MBP-Trim39. This inhibition was not observed using the C44A mutant, suggesting that E3 ubiquitin ligase activity is required for APC/C inhibition (Fig. 1 C). Indeed, cyclin B1 was more rapidly degraded in the presence of the catalytically inactive Trim39 mutant, suggesting that this protein might interfere with the functioning of the endogenous protein. To confirm a direct role for Trim39 in APC/C inhibition, we incubated APC/C immunoprecipitated from HeLa cells with MBP or MBP-Trim39, E1, E2, ubiquitin, and ...

Cdh1 - Cadherin-1 precursor - Rattus norvegicus (Rat) - Cdh1 gene & proteinCdh1 - Cadherin-1 precursor - Rattus norvegicus (Rat) - Cdh1 gene & protein

CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent ... Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q9R0T4. P09803. Q4KML8. UPI00017BDAFC. ...
more infohttp://www.uniprot.org/uniprot/Q9R0T4

SIAMESE Cooperates With the CDH1-like Protein CCS52A1 to Establish Endoreplication in Arabidopsis thaliana Trichomes | GeneticsSIAMESE Cooperates With the CDH1-like Protein CCS52A1 to Establish Endoreplication in Arabidopsis thaliana Trichomes | Genetics

CCS52A1 encodes a CDH1/FZR-like protein, a class of proteins that function as activators of the anaphase-promoting complex. ... the CCS52A proteins seem likely to be the most similar in function to CDH1/FZR proteins (Fülop et al. 2005). Arabidopsis has ... CDH1/FZR proteins are substrate-specific activators of the APC/C that regulate M/G1-phase-specific proteolysis and are required ... During the mitotic cell cycle, APC/CCDH1 targets proteins containing the Dbox motif, and in some cases other amino acid ...
more infohttp://www.genetics.org/content/185/1/257

APC/C activator protein CDH1 - WikipediaAPC/C activator protein CDH1 - Wikipedia

Cdh1 is a cdc20 homolog and is Frizzy-related (Drosophila). The protein sequence of cdh1 consists of 566 amino acids and has a ... Cdh1 is one of the co- activator proteins of APC/c and therefore contributes to the regulation of protein degradation, by ... When cdh1 is hyperphosphorytaled, the association of cdh1 to the APC/c is blocked, thus leading to the inactive form of cdh1. ... Cdh1 has 7 WD repeats, which are located between the middle of the protein and the C-terminal end. They have a conserved core ...
more infohttps://en.wikipedia.org/wiki/APC/C_activator_protein_CDH1

CDH1 Protein Human Recombinant | Cadherin 1 | ProSpecCDH1 Protein Human Recombinant | Cadherin 1 | ProSpec

E-Cadherin Human Recombinant produced in HEK cells is a secreted protein with the sequence of Human E-Cadherin (amino acids ... The CDH1 protein was lyophilized from a 0.2µm filtered solution in PBS, pH7.4. ... It is recommended to reconstitute the lyophilized CDH1 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further ... For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).. Please prevent freeze-thaw cycles. ...
more infohttps://www.prospecbio.com/cdh1_human_hek

Tissue expression of CDH1 - Staining in vagina - The Human Protein AtlasTissue expression of CDH1 - Staining in vagina - The Human Protein Atlas

Expression of CDH1 (CD324, UVO, uvomorulin) in vagina tissue. Antibody staining with HPA004812, CAB000087, CAB028364, CAB072855 ... Protein evidence (Ezkurdia et al 2014). Protein evidence (Kim et al 2014). RAS pathway related proteins. Ribosomal proteins. ... Plasma proteins. Potential drug targets. Predicted intracellular proteins. Predicted membrane proteins. Predicted secreted ... Protein expressioni. The protein expression bar, with the units not detected (n), low (l), medium (m) and high (h), is based on ...
more infohttp://www.proteinatlas.org/ENSG00000039068-CDH1/tissue/vagina

Tissue expression of CDH1 - Staining in esophagus - The Human Protein AtlasTissue expression of CDH1 - Staining in esophagus - The Human Protein Atlas

Expression of CDH1 (CD324, UVO, uvomorulin) in esophagus tissue. Antibody staining with HPA004812, CAB000087, CAB028364, ... Protein evidence (Ezkurdia et al 2014). Protein evidence (Kim et al 2014). RAS pathway related proteins. Ribosomal proteins. ... Plasma proteins. Potential drug targets. Predicted intracellular proteins. Predicted membrane proteins. Predicted secreted ... Protein expressioni. The protein expression bar, with the units not detected (n), low (l), medium (m) and high (h), is based on ...
more infohttp://www.proteinatlas.org/ENSG00000039068-CDH1/tissue/esophagus

CDH1 protein (Saccharomyces cerevisiae) - STRING interaction networkCDH1 protein (Saccharomyces cerevisiae) - STRING interaction network

Edges represent protein-protein associations. associations are meant to be specific and meaningful, i.e. proteins jointly ... CDH1. YNL172W. YGL003C. Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ... CDH1. YFR028C. YGL003C. Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I ... Network nodes represent proteins. splice isoforms or post-translational modifications are collapsed, i.e. each node represents ...
more infohttps://string-db.org/network/4932.YGL003C

CDH1 (gene) - WikipediaCDH1 (gene) - Wikipedia

... or uvomorulin is a protein that in humans is encoded by the CDH1 gene.[5] CDH1 has also been designated as CD324 (cluster of ... Genetic and epigenetic control of CDH1[edit]. Several proteins such as SNAI1/SNAIL,[58][59] ZFHX1B/SIP1,[60] SNAI2/SLUG,[61][62 ... Inactivation of CDH1 in 50% of diffuse gastric carcinomas.[56]. *Complete loss of E-cadherin protein expression in 84% of ... protein binding. • ankyrin binding. • gamma-catenin binding. • beta-catenin binding. • GTPase activating protein binding. • ...
more infohttps://en.wikipedia.org/wiki/CDH1_

Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor...Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor...

STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41, D808-15 ( ... CDH1/2, this compartment contains the CTNNB1 regulation and its influence on CDH1 as well as angiogenesis and extracellular ... E2F1 is a remarkable example of a network hub as this protein interacts with many genes, proteins, and other transcription ... More specifically, we retrieved data on protein-protein interactions from STRING58 (v9.1) and HPRD59 (release 9). Transcription ...
more infohttps://www.nature.com/articles/s41467-017-00268-2?error=cookies_not_supported&code=c1cea051-6d02-48f0-83ba-f2a31cb0d8e6

Molecular mechanisms underlying RB protein function.  - PubMed - NCBIMolecular mechanisms underlying RB protein function. - PubMed - NCBI

These different conformational changes inhibit specific RB-protein interactions. CDH1, CDC20 homologue 1; CDK, cyclin-dependent ... a , Schematic depiction of the F box protein S phase kinase-associated protein 2 (SKP2) recognizing phosphorylated p27. Binding ... a , Model of active and complexes with E2F and an L-X-C-X-E peptide (Protein Data Bank (PDB) codes: 2QDJ, 1GUX, 1N4M and 2AZE ... Molecular mechanisms underlying RB protein function.. Dick FA1, Rubin SM.. Author information. 1. London Regional Cancer ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23594950?dopt=Abstract

Figure 3: pRB-APCcdh1 association, ubiquitination of Skp2 and p27Kip1 protein accumulation are coordinated during pRB-mediated...Figure 3: pRB-APCcdh1 association, ubiquitination of Skp2 and p27Kip1 protein accumulation are coordinated during pRB-mediated...

d, e) As controls for the specificity of APCcdh1- and pRB-mediated Skp2 protein turnover, SAOS-tetRB cells were transfected ... Figure 3: pRB-APCcdh1 association, ubiquitination of Skp2 and p27Kip1 protein accumulation are coordinated during pRB-mediated ... Cdh1 siRNA cotransfection served as a control. Immunoprecipitations from MG132-treated cell extracts were carried out using ... a) pRB was induced by tetracycline in a stably transfected SAOS2 cell line (SAOS-tetRB) and protein samples for immunoblotting ...
more infohttps://www.nature.com/articles/ncb1532/figures/3?error=cookies_not_supported&code=7a6058b4-96c7-44c9-9ba2-ffd15be48fdf

CDH1 (mouse)CDH1 (mouse)

Protein Mutation Frequency in Cancer. The lollipop plot above illustrates recurrent (observed in 3 or more out of 4440 TCGA ...
more infohttps://www.phosphosite.org/proteinAction.action?id=7661&showAllSites=true

Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle.  - PubMed - NCBIDirect visualization of cell division using high-resolution imaging of M-phase of the cell cycle. - PubMed - NCBI

APC, anaphase-promoting complex; C, cytokinesis; Cdc20, cell-division cycle protein 20; Cdh1, Cdc20 homologue-1; K, ... d) At E14.5 eGFP staining co-localizes with brain lipid-binding protein (BLBP; red), a known marker for RG cells in the VZ ( ... a) Schemes of subcellular localization of the eGFP-anillin fusion protein during the cell cycle and of the CAG-eGFP-anillin ... Here we overcome these limitations by generating an in vivo reporter system using the scaffolding protein anillin fused to ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23011130?dopt=Abstract

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young...Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young...

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young ... CDH1) in hereditary diffuse gastric cancer (HDGC). We screened a series of 66 young gastric cancer probands for germline CDH1 ... cDNAs encoding either the wild-type protein or mutant forms of E-cadherin were stably transfected into CHO (Chinese hamster ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=6678

FZR3 - Protein FIZZY-RELATED 3 - Arabidopsis thaliana (Mouse-ear cress) - FZR3 gene & proteinFZR3 - Protein FIZZY-RELATED 3 - Arabidopsis thaliana (Mouse-ear cress) - FZR3 gene & protein

Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/ ... This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.. View all proteins of ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... Protein FIZZY-RELATED 3Add BLAST. 481. Proteomic databases. PaxDb, a database of protein abundance averages across all three ...
more infohttps://www.uniprot.org/uniprot/Q8LPL5

Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F | Journal of Cell ScienceCdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F | Journal of Cell Science

Therefore we then turned to the CDH1−/− iMEFs.. Immunoblotting confirmed that CDH1−/− iMEFs were indeed Cdh1-deficient (Fig. 6B ... Cenp-F degradation occurs normally in Cdh1-null MEFS. To test the role of Cdh1 more rigorously, we immortalised CDH1+/+ and ... This not only initiates Cdh1-activated APC/C (APC/CCdh1)-mediated degradation but, because Cdc20 is itself a APC/CCdh1 ... 2000). Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol. Biol. Cell 11, 1555-1569. ...
more infohttps://jcs.biologists.org/content/123/3/321

DCHS2 Gene - GeneCards | PCD23 Protein | PCD23 AntibodyDCHS2 Gene - GeneCards | PCD23 Protein | PCD23 Antibody

Protein Coding), Dachsous Cadherin-Related 2, including: function, proteins, disorders, pathways, orthologs, and expression. ... cdh-1 34 *21 (a). OneToMany. *III:2910970-2935606. sea squirt. (Ciona savignyi) ... Protein Symbol:. Q6V1P9-PCD23_HUMAN. Recommended name:. Protocadherin-23. Protein Accession:. Q6V1P9. Secondary Accessions: * ... Protein Expression for DCHS2 Gene. See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=DCHS2

A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression |...A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression |...

... increase of EMT-associated proteins such as fibroblast activation protein (FAP), lysyl oxidase, tenascin C and SPARC (secreted ... ACTA2, smooth muscle actin; CDH1, E-cadherin; CLDN, claudin; CTGF, connective tissue growth factor; DDR2, discoid domain ... This might be caused by the downregulation of various multiple drug resistance proteins in the 3sp cells (Supplementary Fig. ... secreted protein, acidic, cystein-rich; TGF-β, transforming growth factor-β; TNC, tenascin C; VIM, vimentin. ...
more infohttps://mct.aacrjournals.org/content/10/5/850.long

Plus itPlus it

... increase of EMT-associated proteins such as fibroblast activation protein (FAP), lysyl oxidase, tenascin C and SPARC (secreted ... ACTA2, smooth muscle actin; CDH1, E-cadherin; CLDN, claudin; CTGF, connective tissue growth factor; DDR2, discoid domain ... This might be caused by the downregulation of various multiple drug resistance proteins in the 3sp cells (Supplementary Fig. ... secreted protein, acidic, cystein-rich; TGF-β, transforming growth factor-β; TNC, tenascin C; VIM, vimentin. ...
more infohttp://mct.aacrjournals.org/content/10/5/850

Recombinant Proteins | OriGeneRecombinant Proteins | OriGene

Recombinant protein of human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) ... Recombinant protein of human v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), G12D mutant, transcript variant b ... Recombinant protein of human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), full length, with N-terminal HIS tag ... Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene ...
more infohttps://www.origene.com/category/proteins/recombinant-proteins?sizes_filter=250+ug&pathways_filter=Endometrial+cancer

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C | PNASStructural analysis of human Cdc20 supports multisite degron recognition by APC/C | PNAS

We next examined the ubiquitination of various securin proteins by APC/CCdh1. Consistent with a previous report (28), mutation ... 2011) Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature 470(7333):274-278. ... Protein Binding and Ubiquitination Assays.. Protein binding and ubiquitination assays were performed as described (39, 40). See ... Protein Purification and Crystallization.. Human Cdc20 proteins were expressed in insect cells and purified with affinity and ...
more infohttps://www.pnas.org/content/109/45/18419?ijkey=69fbce502fb8560ccf45b87ac4e02c0323ff9db6&keytype2=tf_ipsecsha

Gene InfoGene Info

Protein. H.sapiens. CDH1. NP_004351. M.musculus. Cdh1. 12550. Gene Info. NP_033994. 81. ... Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_004351 Protein ... MF] protein binding *[MF] protein domain specific binding *[MF] protein phosphatase binding BioCarta Pathways. ... BP] protein homooligomerization *[BP] protein localization to plasma membrane *[BP] protein metabolic process *[BP] regulation ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=461086&LLNO=999

JCI -
Autophagy is required for lung development and morphogenesisJCI - Autophagy is required for lung development and morphogenesis

Double-IF staining for Ki67 and CDH1 (Figure 7A) revealed that the number of CDH1+ epithelial cells staining positively for ... Graphs show densitometric analysis of BAX, C-CASP3, and C-PARP protein expression. ACTB was used as a protein loading control. ... Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in ... surfactant protein B (SFTPB), and surfactant protein C (SFTPC) (37, 41-45), we next assessed the differentiation of respiratory ...
more infohttps://jci.org/articles/view/127307

JCI -
Autophagy is required for lung development and morphogenesisJCI - Autophagy is required for lung development and morphogenesis

Double-IF staining for Ki67 and CDH1 (Figure 7A) revealed that the number of CDH1+ epithelial cells staining positively for ... Graphs show densitometric analysis of BAX, C-CASP3, and C-PARP protein expression. ACTB was used as a protein loading control. ... Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in ... surfactant protein B (SFTPB), and surfactant protein C (SFTPC) (37, 41-45), we next assessed the differentiation of respiratory ...
more infohttps://www.jci.org/articles/view/127307

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

0 (CDH1 protein, human); 0 (Cadherins); 0 (Vimentin). [Em] M s de entrada:. 1708. ... 0 (Adaptor Proteins, Signal Transducing); 0 (Antineoplastic Agents); 0 (LIM Domain Proteins); 0 (LMNA protein, human); 0 (Lamin ... MET protein, human); EC 2.7.10.1 (Proto-Oncogene Proteins c-met); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 ... and NAD-dependent protein deacetylase sirtuin-3 (SIRT3). Knockdown of any of these proteins was shown in previous studies to ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=C04.557.450.565.835
  • These progenitors are unique to the second tracheal metamere as homologous cells from other segments, express fizzy-related (fzr) , the Drosophila homolog of CDH1 protein of the APC complex , and enter endocycle and do not contribute to adult trachea. (sdbonline.org)
  • Methylation of CDH1 promotors can alter the expression of its protein and is also considered as a contributor to various cancers. (springer.com)
  • In this study, CDH1 methylation and expression profile as well as prognosis of 38 cases of eyelid SCC and the corresponding adjacent tissues were analyzed to clarify the role of CDH1 methylation in SCC carcinogenesis and prognosis. (springer.com)
  • Methylation was detected by PCR, and CDH1 expression was evaluated by immunohistochemistry. (springer.com)
  • We observed that CDH1 methylation is significantly correlated with decreased CDH1 protein expression in eyelid SCC patients. (springer.com)
  • Patients with methylation and low expression of CDH1 are significantly associated with advanced and aggressive phenotypes. (springer.com)
  • Therefore, CDH1 methylation and CDH1 expression are both independent prognostic factors for prognosis of eyelid SCC patients. (springer.com)
  • CDH1 promoter methylation in patients with cervical carcinoma: a systematic meta-analysis with trial sequential analysis. (nih.gov)
  • The protein phosphatase Cdc14 dephosphorylates Cdh1 and therefore activates APCCdh1. (wikipedia.org)
  • Activation can be induced by dephosphorylation through the phosphatase cdc14, which leads to the binding of cdh1 to the APC/c. (wikipedia.org)
  • Both processes require the Cdc14 phosphatase, whose release from the nucleolus during anaphase causes dephosphorylation and thereby activation of Cdh1 and accumulation of another protein, Sic1. (sdbonline.org)
  • Our findings suggest that the expression of VIM and CDH1 can identify a subset of IDCs of the breast with a mesenchymal phenotype associated with poor prognosis, high-grade lesion, and high mitotic index. (scielo.br)
  • In conclusion, CDH1 rs5030625 GAGA genotype and TERT rs2736098 GG genotype in combination with clinical parameters may be prognostic factors rather than susceptibility factors during the progression of FBC. (cdc.gov)
  • When CC polyubiquitin is free (unanchored-polyubiquitin), it also has CC distinct roles, such as in activation of protein kinases, and in CC signaling (By similarity). (univ-lyon1.fr)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Deregulation of arid1a, cdh1, cmet and pik3ca and target-related microrna expression in gastric cancer. (springer.com)
  • Especially the residue R56 seems to be important for the binding to APC/c in vitro and Cdh1 function in vivo. (wikipedia.org)
  • One hundred five patients with FBC and 110 non-FBC (NFBC) were genotyped to elucidate the potential association between CDH1 rs5030625 polymorphism and TERT rs2736098 polymorphism by polymerase chain reaction-restriction fragment length polymorphism. (cdc.gov)
  • A collection of articles that focus on an array of different scientific topics such as pathways, cancer, transmembrane proteins. (cusabio.com)
  • Pei Y, Wang P, Liu H, He F, Ming L. Foxq1 promotes esophageal cancer proliferation and metastasis by negatively modulating cdh1. (springer.com)