Cdh1 proteins. Medical search

Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.

Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

Highly conserved proteins that specifically bind to and activate the anaphase-promoting complex-cyclosome, promoting ubiquitination and proteolysis of cell-cycle-regulatory proteins. Cdc20 is essential for anaphase-promoting complex activity, initiation of anaphase, and cyclin proteolysis during mitosis.

Ethers that are linked to a benzene ring structure.

Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.

A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc5, along with Apc4, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc4, along with Apc5, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.

Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.

An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.

The largest subunit of the anaphase-promoting complex. It acts primarily as a scaffold for the proper organization and arrangement of subunits. The C-terminal region of Apc1 contains a series of tandem amino acid repeats that are also seen in the 26S proteasome regulatory particle, and may assist with forming and stabilizing protein-protein interactions.

Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

A cyclin subtype that is transported into the CELL NUCLEUS at the end of the G2 PHASE. It stimulates the G2/M phase transition by activating CDC2 PROTEIN KINASE.

Tumors or cancer of the STOMACH.

A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.

A highly evolutionarily conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc subunits 6, 7, and 8, have been shown to mediate protein-protein interactions, suggesting that Apc3 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to co-activators and APC-C inhibitors.

A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.

Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.

The phase of cell nucleus division following PROPHASE, when the breakdown of the NUCLEAR ENVELOPE occurs and the MITOTIC SPINDLE APPARATUS enters the nuclear region and attaches to the KINETOCHORES.

The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.

Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.

Together with the Apc2 subunit, forms the catalytic core of the E3 ubiquitin ligase, anaphase-promoting complex-cyclosome. It has a RING H2 domain which interacts with the cullin domain of Apc2. Apc11 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Apc10 is necessary for coactivator-dependent substrate recognition by the anaphase-promoting complex-cyclosome. It binds the Apc2 subunit, which is a part of the catalytic core, and interacts with coactivators Cdh1 or Cdc20 to recruit substrates to the complex.

Mechanosensing organelles of hair cells which respond to fluid motion or fluid pressure changes. They have various functions in many different animals, but are primarily used in hearing.

Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.

The period of the CELL CYCLE preceding DNA REPLICATION in S PHASE. Subphases of G1 include "competence" (to respond to growth factors), G1a (entry into G1), G1b (progression), and G1c (assembly). Progression through the G1 subphases is effected by limiting growth factors, nutrients, or inhibitors.

Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.

Presence of less than the normal amount of hair. (Dorland, 27th ed)

Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.

The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. (1/136)

BACKGROUND: Exit from mitosis requires inactivation of mitotic cyclin-dependent kinases (CDKs). A key mechanism of CDK inactivation is ubiquitin-mediated cyclin proteolysis, which is triggered by the late mitotic activation of a ubiquitin ligase known as the anaphase-promoting complex (APC). Activation of the APC requires its association with substoichiometric activating subunits termed Cdc20 and Hct1 (also known as Cdh1). Here, we explore the molecular function and regulation of the APC regulatory subunit Hct1 in Saccharomyces cerevisiae. RESULTS: Recombinant Hct1 activated the cyclin-ubiquitin ligase activity of APC isolated from multiple cell cycle stages. APC isolated from cells arrested in G1, or in late mitosis due to the cdc14-1 mutation, was more responsive to Hct1 than APC isolated from other stages. We found that Hct1 was phosphorylated in vivo at multiple CDK consensus sites during cell cycle stages when activity of the cyclin-dependent kinase Cdc28 is high and APC activity is low. Purified Hct1 was phosphorylated in vitro at these sites by purified Cdc28-cyclin complexes, and phosphorylation abolished the ability of Hct1 to activate the APC in vitro. The phosphatase Cdc14, which is known to be required for APC activation in vivo, was able to reverse the effects of Cdc28 by catalyzing Hct1 dephosphorylation and activation. CONCLUSIONS: We conclude that Hct1 phosphorylation is a key regulatory mechanism in the control of cyclin destruction. Phosphorylation of Hct1 provides a mechanism by which Cdc28 blocks its own inactivation during S phase and early mitosis. Following anaphase, dephosphorylation of Hct1 by Cdc14 may help initiate cyclin destruction. (+info)

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. (2/136)

The separation of sister chromatids in anaphase is followed by spindle disassembly and cytokinesis. These events are governed by the anaphase-promoting complex (APC), which triggers the ubiquitin-dependent proteolysis of key regulatory proteins: anaphase requires the destruction of the anaphase inhibitor Pds1, whereas mitotic exit requires the destruction of mitotic cyclins and the inactivation of Cdk1. We find that Pds1 is not only an inhibitor of anaphase, but also blocks cyclin destruction and mitotic exit by a mechanism independent of its effects on sister chromatid separation. Pds1 is also required for the mitotic arrest and inhibition of cyclin destruction that occurs after DNA damage. Even in anaphase cells, where Pds1 levels are normally low, DNA damage stabilizes Pds1 and prevents cyclin destruction and mitotic exit. Pds1 blocks cyclin destruction by inhibiting its binding partner Esp1. Mutations in ESP1 delay cyclin destruction; overexpression of ESP1 causes premature cyclin destruction in cells arrested in metaphase by spindle defects and in cells arrested in metaphase and anaphase by DNA damage. The effects of Esp1 are dependent on Cdc20 (an activating subunit of the APC) and on several additional proteins (Cdc5, Cdc14, Cdc15, Tem1) that form a regulatory network governing mitotic exit. We speculate that the inhibition of cyclin destruction by Pds1 may contribute to the ordering of late mitotic events by ensuring that mitotic exit is delayed until after anaphase is initiated. In addition, the stabilization of Pds1 after DNA damage provides a mechanism to delay both anaphase and mitotic exit while DNA repair occurs. (+info)

Regulation of APC activity by phosphorylation and regulatory factors. (3/136)

Ubiquitin-dependent proteolysis of Cut2/Pds1 and Cyclin B is required for sister chromatid separation and exit from mitosis, respectively. Anaphase-promoting complex/cyclosome (APC) specifically ubiquitinates Cut2/Pds1 at metaphase-anaphase transition, and ubiquitinates Cyclin B in late mitosis and G1 phase. However, the exact regulatory mechanism of substrate-specific activation of mammalian APC with the right timing remains to be elucidated. We found that not only the binding of the activators Cdc20 and Cdh1 and the inhibitor Mad2 to APC, but also the phosphorylation of Cdc20 and Cdh1 by Cdc2-Cyclin B and that of APC by Polo-like kinase and cAMP-dependent protein kinase, regulate APC activity. The cooperation of the phosphorylation/dephosphorylation and the regulatory factors in regulation of APC activity may thus control the precise progression of mitosis. (+info)

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. (4/136)

The anaphase-promoting complex/cyclosome (APC) is a tightly cell cycle-regulated ubiquitin-protein ligase that targets cyclin B and other destruction box-containing proteins for proteolysis at the end of mitosis and in G1. Recent work has shown that activation of the APC in mitosis depends on CDC20, whereas APC is maintained active in G1 via association with the CDC20-related protein CDH1. Here we show that the mitotic activator CDC20 is the only component of the APC ubiquitination pathway whose expression is restricted to proliferating cells, whereas the APC and CDH1 are also expressed in several mammalian tissues that predominantly contain differentiated cells, such as adult brain. Immunocytochemical analyses of cultured rat hippocampal neurons and of mouse and human brain sections indicate that the APC and CDH1 are ubiquitously expressed in the nuclei of postmitotic terminally differentiated neurons. The APC purified from brain contains all core subunits known from proliferating cells and is tightly associated with CDH1. Purified brain APC(CDH1) has a high cyclin B ubiquitination activity that depends less on the destruction box than on the activity of mitotic APC(CDC20). On the basis of these results, we propose that the functions of APC(CDH1) are not restricted to controlling cell-cycle progression but may include the ubiquitination of yet unidentified substrates in differentiated cells. (+info)

The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. (5/136)

The cyclosome pathway of ubiquitin-mediated proteolysis plays an essential role in cell cycle control. The multisubunit cyclosome is regulated by transient interactions with Fizzy (Fzy) and Fizzy-related (Fzr) genes. We report here that both Fzy and Fzr are transcribed in a cell cycle specific but distinct manner. Fzy transcription starts after the restriction point in late G1 and ceases upon cell division. Fzr transcription also ceases upon cell division but resumes already in mid G1, before the restriction point, and takes place also in G0. Fzr has further a striking cell cycle specific pattern of mRNA stability. During most of the cell cycle its message is fairly stable, however upon exit from mitosis it is rapidly degraded. This result is puzzling because Fzr is essential for cyclosome activity in G1, and points to a complex pattern of Fzr regulation. (+info)

Two different modes of cyclin clb2 proteolysis during mitosis in Saccharomyces cerevisiae. (6/136)

Sister chromatid separation and mitotic exit are triggered by the anaphase-promoting complex (APC/C) which is a multi-subunit ubiquitin ligase required for proteolytic degradation of various target proteins. Cdc20 and Cdh1 are substrate-specific activators of the APC/C. It was previously proposed that Cdh1 is essential for proteolysis of the yeast mitotic cyclin Clb2. We show that Clb2 proteolysis is triggered by two different modes during mitosis. A fraction of Clb2 is degraded during anaphase in the absence of Cdh1. However, a second fraction of Clb2 remains stable during anaphase and is degraded in a Cdh1-dependent manner as cells exit from mitosis. Most of cyclin Clb3 is degraded independently of Cdh1. Our data imply that degradation of mitotic cyclins is initiated by a Cdh1-independent mechanism. (+info)

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. (7/136)

The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and specific. One key component of the degradation system, the anaphase promoting complex (APC), is a ubiquitin protein ligase. It is activated both during mitosis and late in mitosis/G(1), by the WD repeat proteins Cdc20 and Cdh1, respectively. These activators target distinct sets of substrates. Cdc20-APC requires a well-defined destruction box (D box), whereas Cdh1-APC confers a different and as yet unidentified specificity. We have determined the sequence specificity for Cdh1-APC using two assays, ubiquitination in a completely defined and purified system and degradation promoted by Cdh1-APC in Xenopus extracts. Cdc20 is itself a Cdh1-APC substrate. Vertebrate Cdc20 lacks a D box and therefore is recognized by Cdh1-APC through a different sequence. By analysis of Cdc20 as a substrate, we have identified a new recognition signal. This signal, composed of K-E-N, serves as a general targeting signal for Cdh1-APC. Like the D box, it is transposable to other proteins. Using the KEN box as a template, we have identified cell cycle genes Nek2 and B99 as additional Cdh1-APC substrates. Mutation in the KEN box stabilizes all three proteins against ubiquitination and degradation. (+info)

Mitotic regulation of the APC activator proteins CDC20 and CDH1. (8/136)

The ordered activation of the ubiquitin protein ligase anaphase-promoting complex (APC) or cyclosome by CDC20 in metaphase and by CDH1 in telophase is essential for anaphase and for exit from mitosis, respectively. Here, we show that CDC20 can only bind to and activate the mitotically phosphorylated form of the Xenopus and the human APC in vitro. In contrast, the analysis of phosphorylated and nonphosphorylated forms of CDC20 suggests that CDC20 phosphorylation is neither sufficient nor required for APC activation. On the basis of these results and the observation that APC phosphorylation correlates with APC activation in vivo, we propose that mitotic APC phosphorylation is an important mechanism that controls the proper timing of APC(CDC20) activation. We further show that CDH1 is phosphorylated in vivo during S, G2, and M phase and that CDH1 levels fluctuate during the cell cycle. In vitro, phosphorylated CDH1 neither binds to nor activates the APC as efficiently as does nonphosphorylated CDH1. Nonphosphorylatable CDH1 mutants constitutively activate APC in vitro and in vivo, whereas mutants mimicking the phosphorylated form of CDH1 are constitutively inactive. These results suggest that mitotic kinases have antagonistic roles in regulating APC(CDC20) and APC(CDH1); the phosphorylation of APC subunits is required to allow APC activation by CDC20, whereas the phosphorylation of CDH1 prevents activation of the APC by CDH1. These mechanisms can explain the temporal order of APC activation by CDC20 and CDH1 and may help to ensure that exit from mitosis is not initiated before anaphase has occurred. (+info)

Example sentences for "Hernia, Diaphragmatic" in english.

1. The baby was diagnosed with a diaphragmatic hernia at birth and underwent surgery to repair it within the first few days of life.
2. The patient experienced severe symptoms of a diaphragmatic hernia, including difficulty swallowing and recurrent vomiting, and was referred for surgical intervention.
3. The surgeon specialized in the repair of congenital diaphragmatic hernias and had successfully treated many infants with this condition.

There are several types of stomach neoplasms, including:

1. Adenocarcinoma: This is the most common type of stomach cancer, accounting for approximately 90% of all cases. It begins in the glandular cells that line the stomach and can spread to other parts of the body.
2. Squamous cell carcinoma: This type of cancer begins in the squamous cells that cover the outer layer of the stomach. It is less common than adenocarcinoma but more likely to be found in the upper part of the stomach.
3. Gastric mixed adenocarcinomasquamous cell carcinoma: This type of cancer is a combination of adenocarcinoma and squamous cell carcinoma.
4. Lymphoma: This is a cancer of the immune system that can occur in the stomach. It is less common than other types of stomach cancer but can be more aggressive.
5. Carcinomas of the stomach: These are malignant tumors that arise from the epithelial cells lining the stomach. They can be subdivided into adenocarcinoma, squamous cell carcinoma, and others.
6. Gastric brunner's gland adenoma: This is a rare type of benign tumor that arises from the Brunner's glands in the stomach.
7. Gastric polyps: These are growths that occur on the lining of the stomach and can be either benign or malignant.

The symptoms of stomach neoplasms vary depending on the location, size, and type of tumor. Common symptoms include abdominal pain, nausea, vomiting, weight loss, and difficulty swallowing. Diagnosis is usually made through a combination of endoscopy, imaging studies (such as CT or PET scans), and biopsy. Treatment depends on the type and stage of the tumor and may include surgery, chemotherapy, radiation therapy, or a combination of these. The prognosis for stomach neoplasms varies depending on the type and stage of the tumor, but early detection and treatment can improve outcomes.

Primary headache disorders are those that are not caused by another medical condition or injury, and include:

1. Migraine: a severe, debilitating headache that can last for hours or even days, often accompanied by sensitivity to light and sound, nausea, and vomiting.
2. Tension headache: a common type of headache that is often described as a dull, squeezing pain on both sides of the head.
3. Cluster headache: a rare and intense form of headache that occurs in clusters or cycles, typically lasting several weeks or months.
4. Sinus headache: a type of headache caused by inflammation or infection in the sinuses.
5. Trigeminal neuralgia: a chronic pain disorder that affects the nerves in the face and head.

Secondary headache disorders are those that are caused by another medical condition or injury, such as:

1. Medication overuse headache: a type of headache that develops as a result of taking too much pain medication.
2. Hormonal headache: a type of headache that occurs due to changes in hormone levels, such as during menstruation or menopause.
3. Headache caused by underlying medical conditions, such as stroke, tumors, or sinusitis.
4. Headache caused by trauma or injury, such as whiplash or a concussion.

Headache disorders can have a significant impact on an individual's quality of life, and can affect their ability to work, sleep, and participate in daily activities. Treatment for headache disorders depends on the underlying cause, but may include medication, lifestyle changes, and alternative therapies such as acupuncture or biofeedback.

The Usher syndromes are a group of rare genetic disorders that affect both hearing and vision. They are caused by mutations in specific genes and can be inherited in an autosomal recessive or X-linked manner. The syndromes are characterized by progressive retinal degeneration, hearing loss, and vestibular dysfunction.

Source: National Institute on Deafness and Other Communication Disorders (NIDCD)

Note: This is a medical definition, and the term "Usher Syndromes" is not commonly used in everyday conversation. It is used primarily in the medical field to describe this specific group of disorders.

There are several types of hypotrichosis, including:

1. Congenital hypotrichosis: This type is present at birth and is caused by genetic mutations.
2. Acquired hypotrichosis: This type can develop later in life due to various factors such as hormonal imbalances, nutritional deficiencies, or certain medical conditions like thyroid disorders or anemia.
3. Localized hypotrichosis: This type affects only a specific area of the body, such as the scalp or eyebrows.
4. Generalized hypotrichosis: This type affects the entire body.

Hypotrichosis can have a significant impact on an individual's self-esteem and quality of life, especially if it results in noticeable hair loss or thinning. Treatment options for hypotrichosis include medications such as minoxidil (Rogaine) and finasteride (Propecia), as well as non-medical treatments like hair transplantation and low-level laser therapy (LLLT). In some cases, hypotrichosis may be a sign of an underlying medical condition, so it is important to consult with a healthcare professional for proper diagnosis and treatment.

Presbycusis is a type of hearing loss that affects older adults and is caused by aging and wear and tear on the hearing system over time. It is a common condition that can cause difficulty hearing high-pitched sounds, understanding speech in noisy environments, and experiencing ringing or other sounds in the ears (tinnitus).

Etymology:

The term "presbycusis" comes from the Greek words "presby," meaning "elderly," and "akouo," meaning "to hear."

Synonyms: age-related hearing loss, sensorineural hearing loss, hearing impairment.

Antonyms: normal hearing, youthful hearing.

Hypernyms: hearing disorder, auditory disorder.

Hyponyms: noise-induced hearing loss, ototoxicity, Meniere's disease.

Collocations: hearing aid, cochlear implant, audiogram, hearing test.

Sentence examples:

1. The 65-year-old man experienced presbycusis and had difficulty understanding his grandchildren's voices.
2. The doctor recommended a hearing aid for the patient's presbycusis.
3. Presbycusis is a common condition in older adults and can be treated with hearing aids or cochlear implants.

Examples of fetal diseases include:

1. Down syndrome: A genetic disorder caused by an extra copy of chromosome 21, which can cause delays in physical and intellectual development, as well as increased risk of heart defects and other health problems.
2. Spina bifida: A birth defect that affects the development of the spine and brain, resulting in a range of symptoms from mild to severe.
3. Cystic fibrosis: A genetic disorder that affects the respiratory and digestive systems, causing thick mucus buildup and recurring lung infections.
4. Anencephaly: A condition where a portion of the brain and skull are missing, which is usually fatal within a few days or weeks of birth.
5. Clubfoot: A deformity of the foot and ankle that can be treated with casts or surgery.
6. Hirschsprung's disease: A condition where the nerve cells that control bowel movements are missing, leading to constipation and other symptoms.
7. Diaphragmatic hernia: A birth defect that occurs when there is a hole in the diaphragm, allowing organs from the abdomen to move into the chest cavity.
8. Gastroschisis: A birth defect where the intestines protrude through a opening in the abdominal wall.
9. Congenital heart disease: Heart defects that are present at birth, such as holes in the heart or narrowed blood vessels.
10. Neural tube defects: Defects that affect the brain and spine, such as spina bifida and anencephaly.

Early detection and diagnosis of fetal diseases can be crucial for ensuring proper medical care and improving outcomes for affected babies. Prenatal testing, such as ultrasound and blood tests, can help identify fetal anomalies and genetic disorders during pregnancy.

CDH1 - E-cadherin (epithelial): E-cadherins are found in epithelial tissue; not to be confused with the APC/C activator protein ... Berx G, Becker KF, Höfler H, van Roy F (1998). "Mutations of the human E-cadherin (CDH1) gene". Human Mutation. 12 (4): 226-37 ... Moran CJ, Joyce M, McAnena OJ (April 2005). "CDH1 associated gastric cancer: a report of a family and review of the literature ... Regulatory proteins include p-120 catenin, α {\displaystyle \alpha } -catenin, β {\displaystyle \beta } -catenin, and vinculin ...

https://en.wikipedia.org/wiki/Cadherin

The gene mutated in HDGC, CDH1, codes for the E-Cadherin protein. This protein serves numerous functions in cell to cell ... CDH1) located on chromosome 16. Individuals who inherit an inactive copy of the CDH1 gene are at significantly elevated risk ... Although CDH1 is by far the most common gene associated with HDGC, around 11% of cases arise in individuals who are negative ... Mutations in CDH1 are also associated with high risk of lobular breast cancers, and may be associated with a mildly elevated ...

https://en.wikipedia.org/wiki/Hereditary_diffuse_gastric_cancer

In that species, one important target is Cdh1/Hct1. Cdh1 associates with the APC and leads to APC activity (anaphase promoting ... "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22 (14): 3524-3535. doi: ... Also, while the protein regulates the Cdk1 ortholog of S. pombe, this occurs through a process unlike that of S. cerevisiae; it ... Cdc14 and Cdc14 are a gene and its protein product respectively. Cdc14 is found in most of the eukaryotes. Cdc14 was defined by ...

https://en.wikipedia.org/wiki/Cdc14

... not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene. Mutations ... CDH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NCBI/NIH/UW entry on ... Inactivation of CDH1 in 50% of diffuse gastric carcinomas. Complete loss of E-cadherin protein expression in 84% of lobular ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ...

https://en.wikipedia.org/wiki/Cadherin-1

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459-68. ... Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ...

https://en.wikipedia.org/wiki/ANAPC7

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459-68. ... Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ... A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition ...

https://en.wikipedia.org/wiki/ANAPC4

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): ... "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol ...

https://en.wikipedia.org/wiki/ANAPC11

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain ... This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ... Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene. ...

https://en.wikipedia.org/wiki/CDC16

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459-68. ... "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol ...

https://en.wikipedia.org/wiki/ANAPC2

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

https://en.wikipedia.org/wiki/ANAPC10

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459-68. ... Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ...

https://en.wikipedia.org/wiki/ANAPC5

A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle. CDC20 appears to act as a ... CDC20 is a protein related to the beta subunit of heterotrimeric G proteins. Near its C-terminus it contains seven WD40 repeats ... Securin is a protein that inhibits separase, which in turn inhibits cohesin, a protein that holds sister chromatids together. ... Importantly, cyclin accumulation is also prevented by Cdh1. CDC20-homologue 1 (Cdh1) plays a complementary role to CDC20 in ...

https://en.wikipedia.org/wiki/CDC20

Seki A, Fang G (2007). "CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit". J. Biol. Chem. 282 ( ... Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene. Human CKAP2 gene, the cDNA of which ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... "Entrez Gene: CKAP2 cytoskeleton associated protein 2". Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1 ...

https://en.wikipedia.org/wiki/CKAP2

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene. FZR1 has been ... Zhou Y, Ching YP, Chun AC, Jin DY (April 2003). "Nuclear localization of the cell cycle regulator CDH1 and its regulation by ... Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM (May 2005). "The WD40 propeller domain of Cdh1 functions as a ...

https://en.wikipedia.org/wiki/FZR1

2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459-68. ... 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase- ... The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby ...

https://en.wikipedia.org/wiki/ANAPC1

2000). "Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1". Genes Dev. 14 (18): 2330 ... 40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene. Ubiquitin, a highly conserved protein ... As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ... ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. GRCh38: Ensembl release 89: ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S27a

... has been shown to interact with Cdh1. FOX proteins GRCh38: Ensembl release 89: ENSG00000111206 - Ensembl, May 2017 GRCm38 ... Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member ... FOXM1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Laoukili J, Alvarez-Fernandez M, Stahl M, Medema RH (September 2008). "FoxM1 is degraded at mitotic exit in a Cdh1-dependent ...

https://en.wikipedia.org/wiki/FOXM1

When STAU1 protein interacts with APC/C adapter proteins Cdc20 and Cdh1, proteasomal degradation is promoted in mitotic cells. ... Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene. Staufen is a ... Monshausen M, Rehbein M, Richter D, Kindler S (2002). "The RNA-binding protein Staufen from rat brain interacts with protein ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...

https://en.wikipedia.org/wiki/STAU1

... has been shown to interact with: Beta-catenin, CDH1, Catenin (cadherin-associated protein), alpha 1, Nephrin and ... Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene. This gene is a classical ... The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a ... Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha ...

https://en.wikipedia.org/wiki/CDH3_(gene)

Cdc20 and Cdh1 are the two activators of particular importance to the cell cycle. These proteins target the APC/C to specific ... Cdh1 does not require APC to be phosphorylated in order to bind, in fact, phosphorylation of Cdh1 by Cdks prevents it from ... It is important to note that the conserved area of the propeller of Cdh1 is much larger than that of Cdc20, allowing Cdh1 to ... Evidence shows that APC3 and APC7 serve to recruit Cdh1 to the anaphase-promoting complex. This further supports that Cdh1 is ...

https://en.wikipedia.org/wiki/Anaphase-promoting_complex

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins ... Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene. The protein encoded by this ... This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly ...

https://en.wikipedia.org/wiki/CDC27

"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... a protein domain important for protein-protein interaction. CDC23 has been shown to interact with CDC27. GRCh38: Ensembl ... This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly ... The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression ...

https://en.wikipedia.org/wiki/CDC23

It is hypothesized that Clb5 and Clb6 are somewhat resistant to APC-Cdh1 degradation since they are primarily regulated by APC- ... Clb5, in particular, has unique hydrophobic section of amino acids that allows specific interactions with proteins in the pre- ... Finally, Clb5-Cdk1 has been shown to be important for the phosphorylation of Cdh1 in yeast, and Clb5 destruction promotes ... An important regulatory event during G1 is the inactivation of the anaphase promoting complex (APC-Cdh1). Clb5 and Clb6 ...

https://en.wikipedia.org/wiki/Clb_5,6_(Cdk1)

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene. This gene encodes a member of the F-box protein ... Cdh1)". Nature Cell Biology. 4 (5): 358-66. doi:10.1038/ncb785. PMID 11988738. S2CID 25403043. Li Z, Hu CY, Mo BQ, Xu JD, Zhao ... and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this ... The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box ...

https://en.wikipedia.org/wiki/FBXO5

Beta-transducin repeat-containing protein (βTRCP) is an FBP that targets emi1-an APC/C-Cdh1 inhibitor-and wee1 for degradation ... Skp1 - Skp1 is an adaptor protein that is essential for the recognition and binding of F-box proteins. Cullin (CUL1) - Cullin ... The SCF complex also marks various other cellular proteins for destruction. SCF contains a variable F-box protein and three ... Instead, FBP affinity for protein substrates is regulated through cyclin-CDK-mediated phosphorylation of target proteins. ...

https://en.wikipedia.org/wiki/SCF_complex

... the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain ... Cadherin-16 is a protein that in humans is encoded by the CDH16 gene. This gene is a member of the cadherin superfamily, genes ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation ...

https://en.wikipedia.org/wiki/CDH16

Swope D, Cheng L, Gao E, Li J, Radice GL (Mar 2012). "Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart ... Plakoglobin has been shown to interact with: APC, CTNNA1, CTNNB1, CDH1, CDH2, CDH3, CDH5, DSG2, DSP, MUC1, PKP2, PTPkappa ( ... Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. ... Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P (Mar 1995). "The APC protein and E-cadherin form similar but independent ...

https://en.wikipedia.org/wiki/Plakoglobin

... a phosphatase that counteracts Cdk1 via activation of Cdh1 and Swi5, a transcriptional activator of Sic1 proteins. While ... promotes formation of APC in association with Cdh1 (APC-Cdh1) to degrade Clb2s. Cdc20 and Cdh1, which are the activators of APC ... This allows for the transcription of S phase genes encoding for proteins that amplify the G1 to S phase switch. Many different ... This action is controlled by the Esp1 protein, which is tightly bound by the anaphase inhibitor Pds1 that is destroyed by the ...

https://en.wikipedia.org/wiki/Biochemical_switches_in_the_cell_cycle

... a phosphatase that counteracts Cdk1 via activation of Cdh1 and Swi5, a transcriptional activator of Sic1 proteins. While ... promotes formation of APC in association with Cdh1 (APC-Cdh1) to degrade Clb2s. Cdc20 and Cdh1, which are the activators of APC ... The double-negative feedback loop, formed by APC-Cdh1 and Sic1, is required to maintain low Clb2-Cdk1 activity because Clb2 ... Without Cdk1-Clb2 complexes to phosphorylate proteins that are involved in spindle dynamics such as Sli15, Ase1, and Ask1, ...

https://en.wikipedia.org/wiki/Mitotic_exit

CDH1, CDH13), are inactivated by it. Hypermethylation is linked to methyl-binding proteins, DNA methyltransferases and histone ...

https://en.wikipedia.org/wiki/CpG_island_hypermethylation

Some cases are inherited, and these cases are often caused by mutations in the CDH1 gene, which encodes the important cell-cell ... a mucin protein, and ErbB2, an oncogenic receptor. When MUC4 and ErbB2 are able to interact, they trigger an activation loop. ...

https://en.wikipedia.org/wiki/Signet_ring_cell_carcinoma

Since many proteins are structurally similar, especially within the same protein family, Broad-spectrum inhibitors can't always ... A few of the common genes frequently observed are APC, CDH1, CDKN2A, MGMT, and RASSF1A (a tumor suppressor). In the cases of ... CXCR4 is a protein that acts as a coreceptor for the entry of HIV. It has been developed as a drug target for anti-HIV therapy ... CYP1A1 is a protein that is well known for its role in chemical compounds and drug metabolism. A study in prostate cancer ...

https://en.wikipedia.org/wiki/Pharmacoepigenetics

... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ... CDH1 subunit of the APC complex recognizes NEDD9 and regulates ubiquitination and subsequent degradation of NEDD9. NEDD9 is ... Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the ... NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction ...

https://en.wikipedia.org/wiki/NEDD9

CTNND1 has been shown to interact with: Beta-catenin, CDH1, CDH2, Collagen, type XVII, alpha 1, Cortactin, FYN, MUC1, Nephrin, ... p120, and called catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene. This gene encodes a member of the ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141-50. ... "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1". Schackmann, R. C. J.; Tenhagen, M.; van de Ven, R. A. H.; ...

https://en.wikipedia.org/wiki/P120_(protein)

2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ... CHD1 contains two tandem N-terminal chromodomains, a SNF2-related domain, a helicase C domain, CDH1/2 SANT-Helical linker, and ... CHD1 is a member of a large family of CHD nucleosome remodelers, though yeast has only one CHD protein, called Chd1. Humans and ... The Chromodomain-Helicase DNA-binding 1 is a protein that, in humans, is encoded by the CHD1 gene. CHD1 is a chromatin ...

https://en.wikipedia.org/wiki/CHD1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ... PTPRK has been shown to interact with: Beta-catenin, E-cadherin (CDH-1), Epidermal growth factor receptor (EGFR), HER2, ... "Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase ... "Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein ...

https://en.wikipedia.org/wiki/PTPRK

HRG Thrombophilia due to protein C deficiency, autosomal dominant; 176860; PROC Thrombophilia due to protein C deficiency, ... CDH1 Gastric cancer, somatic; 137215; APC Gastric cancer, somatic; 137215; CASP10 Gastric cancer, somatic; 137215; ERBB2 ... SLITRK1 Trifunctional protein deficiency; 609015; HADHA Trifunctional protein deficiency; 609015; HADHB Trigonocephaly; 190440 ... G6PC3 D-bifunctional protein deficiency; 261515; HSD17B4 De la Chapelle dysplasia; 256050; SLC26A2 De Sanctis-Cacchione ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. ... FYN has been shown to interact with: ADD2, BCAR1, C-Raf, CBLC, CD36, CD44, CDH1, CHRNA7, CTNND1, CBL, CSF1R, DLG4, Dystroglycan ... Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ...

https://en.wikipedia.org/wiki/FYN

... and Fbxos containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by ... Cdh1) in G1 phase". The EMBO Journal. 27 (4): 679-91. doi:10.1038/emboj.2008.6. PMC 2262036. PMID 18239684. Bashir T, Pagan JK ... The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), ... Yam CH, Ng RW, Siu WY, Lau AW, Poon RY (January 1999). "Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein ...

https://en.wikipedia.org/wiki/SKP2

Amon's team demonstrated that CDC20 is the target protein in the spindle checkpoint during mitosis. Amon's more recent work has ... Vistinin, Rosella; Prinz, Susanne; Amon, Angelika (1997). "CDC20 and CDH1: A Family of Substrate-Specific Activators of APC- ... More specifically, she demonstrated that CDC28 protein kinase is not required for the metaphase to anaphase transition and CLB2 ... and interference with protein biosynthesis. Amon has also examined trisomy in the mouse as a model of mammalian cell growth and ...

https://en.wikipedia.org/wiki/Angelika_Amon

DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... CDH1, CDH2, CDH3, CDK5R1, CHUK, CTNND1, CTNNA1, EGFR, Emerin ESR1 FHL2, GSK3B, HER2/neu, HNF4A, IKK2, LEF1 including ... In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as ... The first helices of the ARM domain form an additional, special protein-protein interaction pocket: This can accommodate a ...

https://en.wikipedia.org/wiki/Catenin_beta-1

Cdc48 modifies proteins structurally involved in these processes and also some ubiquitinated proteins which are thus targeted ... For example, the dephosphorylation of CDH1 allows the APC/C to bind CDH1. APC/CCDH1 targets CDC20 for proteolysis, resulting in ... a protein that mechanically employs its ATPase activity to alter target protein conformation. Cdc48 is necessary for spindle ... For example, NuMA is a minus-end crosslinking protein and Cdk substrate whose dissociation from the microtubule is effected by ...

https://en.wikipedia.org/wiki/Telophase

Subsequently, in case of a second-hit CDH1 (gene) inactivation, E-cadherin protein expression is undetectable and, consequently ... In case of a CDH1 (gene) mutation the E-cadherin function can be deregulated, with a decreased cell-cell adhesion and increased ... Research studies identified novel CDH1 germline variants in women with diagnosed lobular breast cancer (in invasive and/or in ... defined this syndrome as a new cancer predisposition and the Authors suggested additional clinical criteria to testing CDH1 in ...

https://en.wikipedia.org/wiki/Hereditary_lobular_breast_cancer

One area deals with molecular processes and the function of certain proteins, often in conjunction with cell signaling and ... and various cadherin coding genes like CDH1 and CDH2. Some recent research has shown that the level of gene expression changes ... Neural development Neurogenesis The Brain Neural tube There are many genes and proteins that contribute to the formation and ... of the same species could be explained by differing levels of expression of these genes and their corresponding proteins. There ...

https://en.wikipedia.org/wiki/Neurogenetics

The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to ... Met has been shown to interact with: CDH1, Cbl gene, GLMN, Grb2, Hepatocyte growth factor, PTPmu, and RANBP9 c-Met inhibitors ... c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is ... PTEN (phosphatase and tensin homolog) is a tumor suppressor gene encoding a protein PTEN, which possesses lipid and protein ...

https://en.wikipedia.org/wiki/C-Met

The primary protein encoded by PFKFB3, iPFK2, consists of 590 amino acids. It has a predicted molecular weight of 66.9 kDa and ... bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1 ... In neurons, PFKFB3 protein abundance is negligible due to the continuous proteasomal degradation of the enzyme. However, ... Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent protein kinase signaling. The four ...

https://en.wikipedia.org/wiki/PFKFB3

The N-terminal region mediates binding of Hs-BUB1 to the mitotic kinetochore protein blinkin (a protein also commonly referred ... In turn APC/C, now in complex with Cdh1, also acts on Bub1 by priming it for degradation to exit mitosis. In addition, ... Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. The protein is bound ... The protein kinase Bub1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome ...

https://en.wikipedia.org/wiki/BUB1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ... PTPRM has been shown to interact with: BCCIP, c-Met, CDH1 E-cadherin (Cadherin-1), CDH2 N-cadherin (Cadherin-2), CDH4 R- ... Disruption of cadherin proteins, by genetic alteration or by changes to the structure or function of the protein, has been ... Rosdahl JA, Mourton TL, Brady-Kalnay SM (2002). "Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase ...

https://en.wikipedia.org/wiki/PTPRM

HDAC2 is broadly regulated by protein kinase 2 (CK2) and protein phosphatase 1 (PP1), but biochemical analysis suggests its ... Histone deacetylase 2 has been shown to interact with: Ataxia telangiectasia and Rad3 related, BUB3, CDC20, CDH1, CHD3, CHD4, ... Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone ... This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a ...

https://en.wikipedia.org/wiki/Histone_deacetylase_2

The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. Learn about this gene and ... The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. This protein is found within ... These CDH1 gene mutations are thought to result in a nonfunctional E-cadherin protein. A loss of functional E-cadherin in these ... CDH1 gene mutations that cause BCD syndrome are thought to result in an abnormal E-cadherin protein that is quickly broken down ...

https://medlineplus.gov/genetics/gene/cdh1/

Mojallal et al.show that this loss is associated with expression of the scaffold protein AmotL2 in human tumours, and reveal ... Acting as a scaffold protein, AmotL2 and its related proteins associate and join together proteins involved in junction ... p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth. 08 ... Proteins associated to the peptides were identified by Orbitrap mass spectrometry. The full list of binding proteins is found ...

https://www.nature.com/articles/ncomms5557?error=cookies_not_supported&code=9bd53ba5-c9a6-458a-bfb5-f30eec8b76a6

... coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal ... An association between the P7-CDH1 haplotype, including two polymorphisms (rs16260A-rs1801552T) and a subset of HER2-positive ... Results indicated the potential evaluation of CDH1 haplotypes in mGC to stratify patients that will benefit from trastuzumab- ... The CDH1 gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human ...

https://www.mdpi.com/1422-0067/19/1/47

What protein functions are associated with "ZEB1"?. This protein has been associated with "Protein Functions". Please view the ... CDH1;. ... What other proteins interact with "ZEB1"?. This protein has ... What is the molecular weight of the protein?. The molecular weight reported by Uniprot for this item is "124kDa".. Please note ... Protein Name. Zinc finger E-box-binding homeobox 1. Description of Target. Transcription Factor AREB6 / transcription factor 8 ...

https://www.avivasysbio.com/areb6-antibody-n-terminal-region-p100657-t100.html

CDC28 Protein Kinase, S cerevisiae D8.811.913.696.620.682.700.200.67.500 D8.811.913.696.620.682.700.646.500.500.375 Cdh1 ... Son of Sevenless Protein, Drosophila D12.776.402.300.700.700.600 Son of Sevenless Proteins D12.776.402.300.700.700 SOS1 Protein ... Proto-Oncogene Protein c-fli-1 D12.776.930.635.400 D12.776.930.720.400 Proto-Oncogene Proteins c-bcl-6 D12.776.930.633 D12.776. ... Proto-Oncogene Protein c-ets-1 D12.776.930.635.100 D12.776.930.720.100 Proto-Oncogene Protein c-ets-2 D12.776.930.635.200 ...

https://decs.bvs.br/P/mnchg2016.txt

Cdh1 Proteins Entry term(s). APC-C Activator Protein CDH1 Cdh1 Protein Cdh1 Subunit, Anaphase Promoting Complex Cdh1 Subunit, ... Protéines Cdh1 Entry term(s):. APC-C Activator Protein CDH1. Cdh1 Protein. Cdh1 Subunit, Anaphase Promoting Complex. Cdh1 ... Cdh1 Proteins - Preferred Concept UI. M0580204. Scope note. Cdh1 is an activator of the anaphase-promoting complex-cyclosome ... Ubiquitin-Protein Ligase Complexes (2004-2013). Public MeSH Note:. 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES ...

https://decs.bvsalud.org/en/ths/resource/?id=55284

Germline truncating mutations in the tumor suppressor gene CDH1 (encoding the cell-to-cell adhesion protein E-cadherin) are ... Gastrointestinal polyposis leads to malabsorption and protein-losing enteropathy, resulting in clinical symptoms of abdominal ...

https://www.ctisus.com/learning/pearls/stomach/adenocarcinoma

Heat shock protein association with clinico-pathological characteristics of gastric cancer in Jordan : HSP70 is predictive of ... Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk. World J Gastroenterol. 2010 Jul 21;16(27):3432-6. ... The prognostic significance of p53, p27 kip1, p21 waf1, HER-2/neu, and Ki67 proteins expression in gastric cancer: a ... finding that the T-antigen protein expression was detected in 39% of the GC cases and none of the non-neoplastic tissues. A ...

https://www.emro.who.int/fr/emhj-volume-28-2022/volume-28-issue-7/gastric-cancer-in-the-arab-world-a-systematic-review.html

... adhesion G protein-coupled receptor E1; Atg5: autophagy related 5; ATG13: autophagy related 13; BECN1: beclin 1; CDH1/E- ... Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass. Zimmerman, Kristin; Liu, Xiaochen; von Kroge, ... Proteins from humeri and calvarial pre-osteoblasts (Pobs) were used to verify the differentially expressed signaling pathways ... Nudix type 5 (NUDT5) has been recently identified as a new cancer-associated protein that is involved in numerous cancers. To ...

https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=mh:Pirofosfatases/metabolismo

4). Up-regulation of Translationally-Controlled Tumour Protein is Associated with Cervical Cancer Progression. ... CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent ... The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a ... Figure 1: Western blot analysis using CDH1 mouse mAb against LNCAP (1),A431 (2), DU145 (3), PC-3 (4), PC-12 (5) and T47D(6) ...

https://affbiotech.com/goods-602-BF0219-E_cadherin_Antibody.html

Ubiquitin ligases promote regulated proteolysis (protein degradation) by attaching chains of a small protein called ubiquitin ... This is mediated by the specificty factors Cdc20 and Cdh1 in late mitosis, and by Cdh1 in G1. ... These are known as Cdc20 and Cdh1.. The APC has two major functions:. 1) To promote the onset of anaphase by allowing ... The APC targets a protein known as securin for degradation. Securin is an inhibitor of the protease called separase that ...

https://everything2.com/title/APC

... by investigating the localisation of six LEM-domain proteins, two BAF proteins and LBR, in human spermatids and spermatozoa. ... Using RT-PCR, IF and western blotting, we show that six of the proteins tested are present in spermatids: LEMD1, LEMD2 (a short ... In spermatids, no protein localised to the nuclear periphery, but five were nucleoplasmic, receding towards the posterior ... In somatic cells, interactions between the NL and the chromatin have been demonstrated: LEM-domain proteins and LBR interact ...

https://rep.bioscientifica.com/view/journals/rep/154/4/REP-17-0358.xml?rskey=0t7f6Q&result=1

Query Trace: Atrophy and CDH1[original query]. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with ... Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa. BMC medical ... Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium. BMC ...

https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Atrophy+and+CDH1&Mysubmit=Search

Multiple proteins involved in transcriptional regulation were identified (Taf1, Jup, Tdrd3, Cdh1, Cenpj, and several histones ... Multiple proteins involved in transcriptional regulation were identified (Taf1, Jup, Tdrd3, Cdh1, Cenpj, and several histones ... Multiple proteins involved in transcriptional regulation were identified (Taf1, Jup, Tdrd3, Cdh1, Cenpj, and several histones ... Multiple proteins involved in transcriptional regulation were identified (Taf1, Jup, Tdrd3, Cdh1, Cenpj, and several histones ...

https://pure.johnshopkins.edu/en/publications/identification-of-%CE%B2-catenin-interacting-proteins-in-nuclear-fract

Receptors are proteins that are found on the surface of a cell or within a cell. These receptors bind to very specific proteins ... While mutations in certain genes can increase the risk of developing breast cancer, specific hereditary mutations in the CDH1 ... In ILC, the inability of cells to stick together is due to the loss of a functioning protein called E-cadherin. 4, 5 Loss of E- ... Ki-67 is a protein that increases as cells prepare to grow (divide). A staining process can measure the percentage of tumor ...

https://lobularbreastcancer.org/faq/

A cytotoxic T-lymphocyte associated protein 4 (CTLA4) expression in T lymphocytes was determined by flow cytometry. In the ... beige-like anchor protein (LRBA) deficiency is characterized by primary immunodeficiency and autoimmunity. Cancer may present ... CDH1, CTNNA1, BRCA1, BRCA2, APC, TP53, STK11, SMAD4, BMPR1A, MSH2, MLH1) [21], and CTLA4 gene were analyzed with targeted ... Deleterious germline mutations in LRBA gene encoding lipopolysaccharide-responsive, beige-like anchor protein (LRBA) have been ...

https://ojrd.biomedcentral.com/articles/10.1186/s13023-017-0682-5

图3 过表达RASSF5对EMT相关蛋白表达的影响Note: A. The correlation of gene expression between RASSF5 and CDH1. B. Protein level of RASSF5, p-GSK ... 图3 过表达RASSF5对EMT相关蛋白表达的影响Note: A. The correlation of gene expression between RASSF5 and CDH1. B. Protein level of RASSF5, p-GSK ... Fig 3 Effects of RASSF5 overexpression on protein expression of EMT-related proteins ... Fig 3 Effects of RASSF5 overexpression

https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2021.06.003

Sections obtained from cdh1-hybridised embryos (E,J,O) confirm the similarity between hgg1 and cdh1 expression. (P-S) Increased ... The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of ... Sections obtained from cdh1-hybridised embryos (E,J,O) confirm the similarity between hgg1 and cdh1 expression. (P-S) Increased ... injection of cdh1 MO(Montero et al., 2005) impairs anterior migration, as occurs in different cdh1 hypomorphic mutants(Kane et ...

https://cob.silverchair.com/dev/article/134/22/4073/64620/Snail1a-and-Snail1b-cooperate-in-the-anterior

https://decs2018.bvsalud.org/P/mnchg2016.txt

https://decs2016.bvsalud.org/P/mnchg2016.txt

https://decs2017.bvsalud.org/P/mnchg2016.txt

Even though many such immune system checkpoints can be found, two distinctive CDH1 pathways governed by cytotoxic T-lymphocyte- ... 24 PD-1/PD-L1 pathway in oncology PD-1 is a sort 1 transmembrane proteins from the Ig superfamily that partcipates in ... associated antigen 4 (CTLA4) and designed cell death proteins 1 (PD-1) and its own ligand PD-L1 possess truly arrive to ... activated by chromosomal rearrangement of some of ROS1 with among 12 different partner protein).6,7 These targeted therapies ...

http://www.cancerdir.com/2018/11/immunotherapy-with-defense-checkpoint-inhibitors-offers-opened-a-fresh-arena-in/

CDH1, RHOA, than the other GC subgroups where these genes are found to be highly mutated [26, 33]. This pattern of mutations ... through its viral proteins and being progressively lost (run) from the host cell after inducing heritable changes in the ... the virus expresses a set of viral proteins as well as viral miRNAs that may impact key cellular pathways and host cell ... Both TIMP2 and EYA1 proteins have been identified as tumour promoters in various cancers inducing cell migration and tumour ...

https://infectagentscancer.biomedcentral.com/articles/10.1186/s13027-022-00469-5

This activates stranded by the protein of important Okazaki reactions. vessel peptide activates a general fatty protein that is ... C provides disabled by either Cdc20 or Cdh1. C, they lead Likewise at Differential changes in the p53 interfereing and their t ... More protein tracts have to be said and reviewed in the activation. encoding pass activation is it seeks involved that ... The s First are a alpha cycle, which remains excreted in all proteins of the product and in all three substrates. The muscle ...

http://erik-mill.de/books/download-einfuhrung-in-die-rontgenfeinstrukturanalyse-lehrbuch-fur-physiker-chemiker-physikochemiker-metallurgen-kristallographen-und-mineralogen-im-2-studienabschnitt-1980.php

CDH1, CDH13, ADAMTS1 and ADAMTS5), tumor suppression (LATS-1 and PTEN), WNT pathway (DKK-3, WIF-1, sFRP-1, sFRP-2, sFRP-4 and ... The encoded p53 protein, which is ubiquitously expressed in tissue, keeps genome stability under stress, and is involved in ... The ligand receptor of WNT contains transmembrane protein Frizzled and LPR5/6. The main downstream target of WNT pathway is β- ... The excess β-catenin protein is phosphorylated and degraded by destruction complex containing APC, AXIN, CK1α, PPP2R4 and GSK-3 ...

https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-1-24

Serine/threonine-protein kinase/endoribonuclease IRE2. ERN2. Q76MJ5. 1 Reference(s). T94H37. Cadherin-1. CDH1. P12830. 1 ... Protein kinase C delta type. PRKCD. Q05655. 2 Reference(s). T65S3S. Tyrosine-protein kinase JAK2. JAK2. O60674. 2 Reference(s) ... Protein kinase C alpha type. PRKCA. P17252. 1 Reference(s). T14JZK. Receptor tyrosine-protein kinase erbB-3. ERBB3. P21860. 2 ... NAD-dependent protein deacetylase sirtuin-1. SIRT1. Q96EB6. 1 Reference(s). T01CL0. Tyrosine-protein kinase Lyn. LYN. P07948. 1 ...

http://www.badd-cao.net:2345/browse/herb/H0793

CDH1 2 SANT HL1, Helicase ATP-bd [-] ... Xenopus protein. *X. laevis 10.1 (J-Strain). *X. laevis 9.2 (J- ...

https://www.xenbase.org/xenbase/gene/showgene.do?method=displayGeneSummary&geneId=482070

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation ... as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer ... Bone Morphogenetic Protein and Notch signaling crosstalk in poor prognosis, mesenchymal subtype colorectal cancer. J Pathol. ...

https://www.birmingham.ac.uk/staff/profiles/cancer-genomic/bardella-chiara.aspx

6. Mitotic regulation of the APC activator proteins CDC20 and CDH1. (nih.gov)
These are known as Cdc20 and Cdh1 . (everything2.com)
This is mediated by the specificty factors Cdc20 and Cdh1 in late mitosis, and by Cdh1 in G1. (everything2.com)

Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. (acrobiosystems.com)

We offer FZR1/CDH1 Peptides and FZR1/CDH1 Proteins for use in common research applications: Blocking/Neutralizing, Control, ELISA, Immunoprecipitation, Protein Array, Western Blot. (novusbio.com)
Our FZR1/CDH1 Peptides and FZR1/CDH1 Proteins can be used in a variety of model species: Human. (novusbio.com)
Choose from our FZR1/CDH1 Peptides and Proteins. (novusbio.com)

19. Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression. (nih.gov)
RESULT: In Enpp1-/- knee joints, we found significant chondrocyte apoptosis and proteomic results showed that abnormal expression of AMP-activated protein kinase (AMPK) signaling pathway may contribute to this phenotype. (bvsalud.org)

WB: For western blot detection of denatured protein samples. (affbiotech.com)

14. Expression Profiles of the Phosphatase and Tensin Homolog (PTEN), CDH1, and CDH2 Genes, and the Cell Membrane Protein, CD133, in the Ishikawa Human Endometrial Adenocarcinoma Cell Line. (nih.gov)
As a proof-of-concept, we applied PMEA to two breast cancer datasets: TCGA and METABRIC and identified several genes, such as GATA3, PIK3CA, MAP3K1, CDH1 and CBFB, whose mutations are significantly mutually exclusive to p53 mutations. (nih.gov)

More than 120 inherited mutations in the CDH1 gene have been found to cause a familial cancer disorder called hereditary diffuse gastric cancer (HDGC). (medlineplus.gov)
Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC). (acrobiosystems.com)

The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. (medlineplus.gov)
E-cadherin belongs to a family of proteins called cadherins whose function is to help neighboring cells stick to one another (cell adhesion) to form organized tissues. (medlineplus.gov)
Another protein called p120-catenin, produced from the CTNND1 gene, helps keep E-cadherin in its proper place in the cell membrane, preventing it from being taken into the cell through a process called endocytosis and broken down prematurely. (medlineplus.gov)
E-cadherin is one of the best-understood cadherin proteins. (medlineplus.gov)
Interactions between the E-cadherin and p120-catenin proteins, in particular, are thought to be important for normal development of the head and face (craniofacial development), including the eyelids and teeth. (medlineplus.gov)
E-cadherin also acts as a tumor suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
Researchers believe that the resulting loss of E-cadherin protein may allow breast cells to grow and divide unchecked, leading to a cancerous tumor. (medlineplus.gov)
The mutations that cause HDGC often lead to the production of an abnormally short, nonfunctional version of the E-cadherin protein or lead to the production of a protein with an altered structure. (medlineplus.gov)
CDH1 gene mutations that cause BCD syndrome are thought to result in an abnormal E-cadherin protein that is quickly broken down. (medlineplus.gov)
A shortage of E-cadherin protein impairs the interaction between E-cadherin and p120-catenin and affects craniofacial development, leading to the features of BCD syndrome. (medlineplus.gov)
The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. (affbiotech.com)
The purity of Human E-Cadherin (155-709) Protein, Fc Tag (Cat. (acrobiosystems.com)
In ILC, the inability of cells to stick together is due to the loss of a functioning protein called E-cadherin. (lobularbreastcancer.org)
4, 5 Loss of E-cadherin is often due to an inactivating mutation in the CDH1 gene. (lobularbreastcancer.org)

Inherited mutations in the CDH1 gene increase a woman's risk of developing a form of breast cancer that begins in the milk-producing glands (lobular breast cancer). (medlineplus.gov)
Inherited mutations in the CDH1 gene are thought to account for only a small fraction of all breast cancer cases. (medlineplus.gov)
CDH1 gene mutations also occur commonly in lobular breast cancers in women without a family history of the disease. (medlineplus.gov)
People with CDH1 gene mutations associated with HDGC have a 56 to 70 percent chance of developing stomach (gastric) cancer in their lifetimes. (medlineplus.gov)
People with HDGC caused by CDH1 gene mutations are born with one mutated copy of the gene in each cell. (medlineplus.gov)
At least five inherited CDH1 gene mutations have been identified in people with blepharocheilodontic (BCD) syndrome. (medlineplus.gov)
Despite the association of CDH1 gene mutations with increased cancer risk (see below), it is unclear whether people with BCD syndrome are at increased risk of developing cancer. (medlineplus.gov)
denoting the phosphorylated overall: congenital download data mining and predictive analysis intelligence mutations bond with proteins who generate with a metabolism with a other Expression. (evakoch.com)

CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. (acrobiosystems.com)

3. ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. (nih.gov)

Cdh1 is an activator of the anaphase-promoting complex-cyclosome and is involved in substrate recognition. (nih.gov)

We believe that determining the mechanisms by which enzymes transfer Ubls will be of broad importance, much like studies of protein kinases have influenced our knowledge of signaling pathways and their roles in diseases. (stjude.org)
multiple cross-links are organic in often all normal surfaces where they suffer acylated first pathways been on their G-protein download data mining and predictive analysis intelligence gathering and. (evakoch.com)

The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. (affbiotech.com)
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. (nih.gov)
iota of ERCC6 heterotrimer due of NOTCH3 mediates to activation of increase proteins in catalytic mechanisms leading NICD3( Talora et al. (erik-mill.de)

Nuclear PTEN is now known to serve lipid-phosphatase-independent functions in regulating the cell cycle by promoting acetylation of p53 and upregulating RAD51 in response to DNA damage [3], and by mediating APC/C tumor suppression by promoting association with the adaptor CDH1 [4]. (careersfromscience.org)
They showed a direct interaction of PTEN with S6K and suggested this is mediated by the master nuclear export protein Crm1. (careersfromscience.org)

33) and the apical receptors of the Fourier protein, the world associated to work induces well viable in some processes of transcription energy. (evakoch.com)

Transcription Factor AREB6 / transcription factor 8 /zinc finger homeodomain enhancer-binding protein inhibits interleukin-2 (IL-2) gene expression. (avivasysbio.com)
expression cross-links are proven in a universal hydrolysis of Kainate primary functions, comprising Transport as adaptors, cities or CDH1 receptors. (evakoch.com)
A cytotoxic T-lymphocyte associated protein 4 (CTLA4) expression in T lymphocytes was determined by flow cytometry. (biomedcentral.com)

CDH1 antibody detects endogenous levels of total CDH1. (affbiotech.com)

The Schulman lab studies the structural basis for post-translational modification by ubiquitin and ubiquitin-like proteins (Ubls). (stjude.org)
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8. (stjude.org)
Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. (stjude.org)
Ubiquitin ligases promote regulated proteolysis (protein degradation) by attaching chains of a small protein called ubiquitin to target proteins, which causes their degradation. (everything2.com)
Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. (nih.gov)

18. Hematopoietic PBX-interacting protein is a substrate and an inhibitor of the APC/C-Cdc20 complex and regulates mitosis by stabilizing cyclin B1. (nih.gov)
The APC has two major mitotic substrate specificity factors that target different proteins for degradation at different times in the cell cycle. (everything2.com)

In somatic cells, interactions between the NL and the chromatin have been demonstrated: LEM-domain proteins and LBR interact with the NL and respectively, the chromatin proteins BAF and HP1. (bioscientifica.com)
We therefore sought to characterise the lamina-chromatin interface during spermiogenesis, by investigating the localisation of six LEM-domain proteins, two BAF proteins and LBR, in human spermatids and spermatozoa. (bioscientifica.com)

Cadherins are calcium-dependent cell adhesion proteins. (affbiotech.com)

NOTCH3, through tandem resulting, links codon of the RNA extracellular PC HuD, which is resulting of IKZF1 into pathophysiological protein-bound kinases. (erik-mill.de)

However, different Ubls alter the functions of their targets in different ways, such as by changing the target's subcellular localization, enzymatic activity, or interactions with other proteins or DNA. (stjude.org)
lipid of interactions bacterial of urban science Constructing hormones to homolog of the acid length TAL1, transcription of the TAL1: COPI-independent biosynthesis, and energy of cyclin D1( CCND1) conduction, which is chain protein( Talora et al. (erik-mill.de)

In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser 552 ) of β-catenin, a multifunctional protein that acts as a transcriptional coregulator in the nucleus. (johnshopkins.edu)
In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser552) of β-catenin, a multifunctional protein that acts as a transcriptional coregulator in the nucleus. (johnshopkins.edu)

An additional mutation that impairs the normal copy of the CDH1 gene is needed for cancer to develop. (medlineplus.gov)

The purpose of this study was to identify β-catenin-interacting proteins that might be involved in transcriptional regulation in rat inner medullary collecting duct (IMCD) cells, using experimental and computational approaches. (johnshopkins.edu)

The establishment and the maintenance of apical-basal cell polarity and eventually the depolarization of a cell is a complex process controlled by a set of core protein complexes. (nature.com)

This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body, such as the inside of the eyelids and mouth. (medlineplus.gov)

The evolutionary conserved proteins localize asymmetrically before morphological polarization and mutually antagonize each other 5 . (nature.com)

No. ECD-H5256) is more than 90% and the molecular weight of this protein is around 200-230 kDa verified by SEC-MALS. (acrobiosystems.com)

In spermatids, no protein localised to the nuclear periphery, but five were nucleoplasmic, receding towards the posterior nuclear pole as spermatids matured. (bioscientifica.com)

19. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (nih.gov)

More protein tracts have to be said and reviewed in the activation. (erik-mill.de)

CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. (acrobiosystems.com)

Post-translational covalent attachment of Ubls to protein targets is a primary eukaryotic regulatory mechanism. (stjude.org)
Ubls are attached to protein targets by a series of molecular handoffs involving an E1 activating enzyme, an E2 conjugating enzyme (or Ubc), an E3 ligase, and the target. (stjude.org)
The APC targets a protein known as securin for degradation. (everything2.com)

Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium. (cdc.gov)

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. (stjude.org)
Purified recombinant fragment of human CDH1 expressed in E. Coli. (affbiotech.com)

Briefly, upon binding DNA, the protein cGAS (cyclic GMP-AMP Synthase) triggers reaction of GTP and ATP to form cGAMP. (cmvpromotor.com)

Securin is an inhibitor of the protease called separase that cleaves a protein called cohesisn , which holds sister chromatids together. (everything2.com)

Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. (nih.gov)

Over 150 enzymes contain known removed in proteins, and Similarly a download data mining and predictive analysis intelligence of these is located found. (evakoch.com)

Anatomy3

Diseases7

Chemicals and Drugs23

Phenomena and Processes10

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. (1/136)

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. (2/136)

Regulation of APC activity by phosphorylation and regulatory factors. (3/136)

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. (4/136)

The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. (5/136)

Two different modes of cyclin clb2 proteolysis during mitosis in Saccharomyces cerevisiae. (6/136)

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. (7/136)

Mitotic regulation of the APC activator proteins CDC20 and CDH1. (8/136)

No images available that match "cdh1 proteins"

Cdh1 Proteins

Hernia, Diaphragmatic

Anaphase-Promoting Complex-Cyclosome

Ubiquitin-Protein Ligase Complexes

Cadherins

Cdc20 Proteins

Phenyl Ethers

Carbohydrate Dehydrogenases

Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome

Cell Cycle Proteins

Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome

DNA Methylation

1-Pyrroline-5-Carboxylate Dehydrogenase

Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome

Securin

Mitosis

Cyclin B

Stomach Neoplasms

Ligases

Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome

S-Phase Kinase-Associated Proteins

Headache Disorders

Ubiquitination

Prometaphase

Anaphase

Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome

Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome

Ubiquitin-Protein Ligases

Usher Syndromes

Mutation

Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome

Stereocilia

Germ-Line Mutation

G1 Phase

Hair Cells, Auditory

Promoter Regions, Genetic

Cellobiose

Hypotrichosis

Presbycusis

Cell Cycle

Saccharomyces cerevisiae Proteins

Fetal Diseases

Diaphragm

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. (1/136)

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. (2/136)

Regulation of APC activity by phosphorylation and regulatory factors. (3/136)

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. (4/136)

The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. (5/136)

Two different modes of cyclin clb2 proteolysis during mitosis in Saccharomyces cerevisiae. (6/136)

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. (7/136)

Mitotic regulation of the APC activator proteins CDC20 and CDH1. (8/136)

Cadherin

Hereditary diffuse gastric cancer

Cdc14

Cadherin-1

ANAPC7

ANAPC4

ANAPC11

CDC16

ANAPC2

ANAPC10

ANAPC5

CDC20

CKAP2

FZR1

ANAPC1

40S ribosomal protein S27a

FOXM1

STAU1

CDH3 (gene)

Anaphase-promoting complex

CDC27

CDC23

Clb 5,6 (Cdk1)

FBXO5

SCF complex

CDH16

Plakoglobin

Biochemical switches in the cell cycle

Mitotic exit