Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
CD40 Ligand
Antigens, CD8
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD34
Antigens, CD28
CD4-CD8 Ratio
Antigens, CD14
Antigens, CD38
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD1
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD2
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD19
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD18
Fas Ligand Protein
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
Antigens, CD56
CD30 Ligand
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Antigens, CD24
Antigens, CD9
CD8-Positive T-Lymphocytes
Antigens, CD43
Antigens, CD7
Antigens, CD20
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD47
Antigens, CD59
Antigens, CD11b
Antigens, CD46
CD4 Lymphocyte Count
Antigens, CD57
Protein Binding
Antigens, CD81
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Antigens, CD11c
Antigens, CD31
Antigens, CD58
Antigens, CD55
Antigens, CD151
Binding Sites
Amino Acid Sequence
RANK Ligand
Antigens, CD63
Antigens, CD13
Antigens, CD11a
Models, Molecular
Immunophenotyping
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Antigens, CD274
Antigens, CD147
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Antigens, CD82
TNF-Related Apoptosis-Inducing Ligand
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Mice, Transgenic
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Cells, Cultured
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Membrane Proteins
B-Lymphocytes
Antigens, Differentiation, T-Lymphocyte
Receptors, Immunologic
Immunologic Memory
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Antigens, CD146
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Antigens, CD15
Antigens, Differentiation
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
4-1BB Ligand
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
OX40 Ligand
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Transfection
T-Lymphocytes, Regulatory
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Base Sequence
Binding, Competitive
Recombinant Fusion Proteins
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Antigens, CD29
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
Interleukin-2
Cytotoxicity, Immunologic
Crystallography, X-Ray
Gene Expression Regulation
Antigens, CD79
CHO Cells
Up-Regulation
Tumor Cells, Cultured
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Structure-Activity Relationship
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Lectins, C-Type
Cell Movement
Monocytes
Antigens, CD164
Reverse Transcriptase Polymerase Chain Reaction
Coculture Techniques
Carrier Proteins
Interleukin-2 Receptor alpha Subunit
Cricetinae
Epitopes, T-Lymphocyte
Antigens, CD53
Molecular Structure
L-Selectin
Cell Differentiation
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Jurkat Cells
Down-Regulation
Programmed Cell Death 1 Ligand 2 Protein
Peptide Fragments
HIV-1
Cell Membrane
Adoptive Transfer
Immunohistochemistry
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Cell Division
Gene Expression
Mutation
Receptors, Antigen, T-Cell, alpha-beta
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Glycoproteins
Antigens, Differentiation, Myelomonocytic
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Mutagenesis, Site-Directed
Phenotype
Receptors, Tumor Necrosis Factor
Receptors, TNF-Related Apoptosis-Inducing Ligand
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Forkhead Transcription Factors
Bone Marrow Cells
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Lymphocyte Subsets
Interleukin-4
HIV Infections
T-Lymphocyte Subsets
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Sequence Homology, Amino Acid
Radioligand Assay
Antigens, Surface
Leukocytes, Mononuclear
Sialic Acid Binding Ig-like Lectin 2
Blotting, Western
Receptors, Chemokine
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Receptors, G-Protein-Coupled
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Dose-Response Relationship, Drug
Antigens, Differentiation, B-Lymphocyte
Solubility
Lymph Nodes
Receptors, Cytoplasmic and Nuclear
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Phosphorylation
Th1 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Cell Communication
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Dimerization
Receptors, IgG
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
Macrophage-1 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Models, Biological
Antibodies, Blocking
Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)
DNA Primers
Protein Structure, Secondary
COS Cells
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Apoptosis Regulatory Proteins
Antigen Presentation
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
Cell Survival
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells. (1/48)
Natural killer cells mediate spontaneously secretory/necrotic killing against rare leukemia cell lines and a nonsecretory/apoptotic killing against a large variety of tumor cell lines. The molecules involved in nonsecretory/apoptotic killing are largely undefined. In the present study, freshly isolated, nonactivated, human NK cells were shown to express TNF, lymphotoxin (LT)-alpha, LT-beta, Fas ligand (L), CD27L, CD30L, OX40L, 4-1BBL, and TNF-related apoptosis-inducing ligand (TRAIL), but not CD40L or nerve growth factor. Complementary receptors were demonstrated to be expressed on the cell surface of solid tumor cell lines susceptible to apoptotic killing mediated by NK cells. Individually applied, antagonists of TNF, LT-alpha1beta2, or FasL fully inhibited NK cell-mediated apoptotic killing of tumor cells. On the other hand, recombinant TNF, LT-alpha1beta2, or FasL applied individually or as pairs were not cytotoxic. In contrast, a mixture of the three ligands mediated significant apoptosis in tumor cells. These findings demonstrate that human NK cells constitutively express several of the TNF family ligands and induce apoptosis in tumor cells by simultaneous engagement of at least three of these cytotoxic molecules. (+info)CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression. (2/48)
Primary CD30(+) cutaneous T-cell lymphomas (CTCLs) represent a spectrum of non-Hodgkin's lymphomas (NHLs) that have been well defined at the clinical, histologic, and immunologic level. This group, which includes 2 main entities (large cell lymphoma and lymphomatoid papulosis [LyP]) and borderline cases, is characterized by the expression of CD30 antigen by neoplastic large cells at presentation, possible spontaneous regression of the skin lesions, and generally favorable clinical course. Although the functional relevance of CD30 and its natural ligand (CD30L) expression in most cases of NHL is presently undefined, previous studies indicate that CD30L is likely to mediate reduction of proliferation in CD30(+) anaplastic large-cell NHL. No information is currently available concerning the expression of CD30L in primary CD30(+) CTCLs. In this study, we investigated the immunophenotypic and genotypic expression of CD30 and CD30L in different developmental phases of skin lesions (growing v spontaneously regressing). By immunohistochemistry, CD30L expression was detected in regressing lesions only; by molecular analysis, the expression of CD30L was clearly higher in regressing lesions than in growing ones. CD30L, while expressed by some small lymphocytes, was most often coexpressed by CD30(+) neoplastic large cells, as demonstrated by 2-color immunofluorescence and by immunohistochemistry on paraffin sections. Taken together, these data suggest that CD30-CD30L interaction may play a role in the pathobiology of primary cutaneous CD30(+) lymphoproliferative disorders. In particular, CD30L (over)expression might have a major role in the mechanism of self-regression of skin lesions, the most distinctive clinical feature of this cutaneous lymphoma subtype. (+info)Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. (3/48)
Infection of inbred mouse strains with Leishmania major is a well characterized model for analysis of T helper (Th)1 and Th2 cell development in vivo. In this study, to address the role of costimulatory molecules CD27, CD30, 4-1BB, and OX40, which belong to the tumor necrosis factor receptor superfamily, in the development of Th1 and Th2 cells in vivo, we administered monoclonal antibody (mAb) against their ligands, CD70, CD30 ligand (L), 4-1BBL, and OX40L, to mice infected with L. major. Whereas anti-CD70, anti-CD30L, and anti-4-1BBL mAb exhibited no effect in either susceptible BALB/c or resistant C57BL/6 mice, the administration of anti-OX40L mAb abrogated progressive disease in BALB/c mice. Flow cytometric analysis indicated that OX40 was expressed on CD4(+) T cells and OX40L was expressed on CD11c(+) dendritic cells in the popliteal lymph nodes of L. major-infected BALB/c mice. In vitro stimulation of these CD4(+) T cells showed that anti-OX40L mAb treatment resulted in substantially reduced production of Th2 cytokines. Moreover, this change in cytokine levels was associated with reduced levels of anti-L. major immunoglobulin (Ig)G1 and serum IgE. These results indicate that anti-OX40L mAb abrogated progressive leishmaniasis in BALB/c mice by suppressing the development of Th2 responses, substantiating a critical role of OX40-OX40L interaction in Th2 development in vivo. (+info)Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. (4/48)
CD153 (CD30 ligand) is a member of the TNF ligand/cytokine family expressed on the surface of human B cells. Upon exposure to IL-4, a critical Ig class switch-inducing cytokine, Ag-activated T cells express CD30, the CD153 receptor. The observation that dysregulated IgG, IgA, and/or IgE production is often associated with up-regulation of T cell CD30 prompted us to test the hypothesis that engagement of B cell CD153 by T cell CD30 modulates Ig class switching. In this study, we show that IgD+ IgM+ B cells up-regulate CD153 in the presence of CD154 (CD40 ligand), IL-4, and B cell Ag receptor engagement. In these cells, CD153 engagement by an agonistic anti-CD153 mAb or T cell CD30 inhibits S mu-->Sgamma, Smu-->Salpha, and S mu-->Sepsilon class switch DNA recombination (CSR). This inhibition is associated with decreased TNFR-associated factor-2 binding to CD40, decreased NF-kappaB binding to the CD40-responsive element of the Cgamma3 promoter, decreased Igamma3-Cgamma3 germline gene transcription, and decreased expression of Ku70, Ku80, DNA protein kinase, switch-associated protein-70, and Msh2 CSR-associated transcripts. In addition, CD153 engagement inhibits IgG, IgA, and IgE production, and this effect is associated with reduced levels of B lymphocyte maturation protein-1 transcripts, and increased binding of B cell-specific activation protein to the Ig 3' enhancer. These findings suggest that CD30+ T cells modulate CSR as well as IgG, IgA, and IgE production by inducing reverse signaling through B cell CD153. (+info)CD30L up-regulates CD30 and IL-4 expression by T cells. (5/48)
CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L(+) neoplastic cells in driving the immune response toward a Th2-polarized non-protective state. (+info)Human angiogenin fused to human CD30 ligand (Ang-CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma. (6/48)
A number of different immunotoxins composed of cell-specific targeting structures coupled to plant or bacterial toxins have increasingly been evaluated for immunotherapy. Because these foreign proteins are highly immunogenic in humans, we have developed a new CD30 ligand-based fusion toxin (Ang-CD30L) using the human RNase angiogenin. The completely human fusion gene was inserted into a pET-based expression plasmid. Transformed Escherichia coli BL21(DE3) were grown under osmotic stress conditions in the presence of compatible solutes. After isopropyl beta-D-thiogalactoside induction, the M(r) 37,000 His(10)-tagged Ang-CD30L was directed into the periplasmic space and functionally purified by a combination of metal ion affinity followed by enterokinase cleavage of the His(10)-Tag and molecular size chromatography. The characteristics of the recombinant protein were assessed by ELISA, flow cytometry, and toxicity assays showing specific activity against CD30(+) Hodgkin-derived cells. Specific binding activity of Ang-CD30L was verified by competition with anti-CD30 monoclonal antibody Ki-4 and commercially available CD30L-CD8 chimeric protein. Ang-CD30L showed RNase activity in vitro. The human recombinant immunotoxin showed significant toxicity toward several CD30-positive cell lines (HDLM-2, L1236, KM-H2, and L540Cy) and exhibited highest cytotoxicity against L540 cells (IC(50) = 8 ng/ml) as determined by cell proliferation assays. CD30 specificity was confirmed by competitive toxicity assays. This is the first report on the specific cytotoxicity of a recombinant completely human fusion toxin with possibly largely reduced immunogenicity for the treatment of CD30-positive malignancies. (+info)Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (7/48)
CD30-CD30 ligand (CD30L) signal transduction appears to protect against autoimmune diabetes by preventing expansion of autoreactive T cells and suppressing Th1-cytokine response. The purpose of this study was to determine whether CD30 or CD30L genes serve as a novel susceptibility gene for type 1 diabetes in humans. We screened CD30 and CD30L genes for polymorphisms in Japanese patients with type 1 diabetes and control subjects. Then, association studies were performed between each of the identified polymorphisms and type 1 diabetes. Direct-sequencing analysis of the CD30 and CD30L genes revealed four polymorphisms: one in the CD30 gene (-201G/A from the transcription start site), and three in the CD30L gene [CA repeat in the promoter, 276G/A in the exon 3, -73T/C in the intron 3 (IVS3 -73T/C)]. Association studies revealed no association between the CD30 and CD30L genes and type 1 diabetes in the whole population. In the female and male subpopulations, however, the frequency of (CA)(9) allele of the CD30L gene promoter or T allele of IVS3 -73T/C polymorphism in the CD30L gene was slightly higher in female patients with type 1 diabetes than that in control females. In conclusion, we could not find significant association between CD30 or CD30L genes and type 1 diabetes, but (CA)(9) allele in the promotor or T allele of -73T/C in intron 3 in CD30L gene might play a minor role in the pathogenesis of type 1 diabetes, only in the Japanese female population. (+info)Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus. (8/48)
CD30 is up-regulated in several human diseases and viral infections but its role in immune regulation is poorly understood. Here, we report the expression of a functional soluble CD30 homologue, viral CD30 (vCD30), encoded by ectromelia (mousepox) virus, a poxvirus that causes a severe disease related to human smallpox. We show that vCD30 is a 12-kD secreted protein that not only binds CD30L with high affinity and prevents its interaction with CD30, but it also induces reverse signaling in cells expressing CD30L. vCD30 blocked the generation of interferon gamma-producing cells in vitro and was a potent inhibitor of T helper cell (Th)1- but not Th2-mediated inflammation in vivo. The finding of a CD30 homologue encoded by ectromelia virus suggests a role for CD30 in antiviral defense. Characterization of the immunological properties of vCD30 has uncovered a role of CD30-CD30L interactions in the generation of inflammatory responses. (+info)
T-t cell interactions during cytotoxic t cell responses. IV. Murine by M Rollinghoff, K Pfizenmaier et al.
Cellular interactions in antibody production - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences
anti-CD40L / CD154 antibody [YMF323.6.2] | GeneTex
CD80 (B7-1) and CD86 (B7-2) antigens on house dust mite-specific T cells in atopic disease function through T-T cell...
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Gentaur Molecular :Reliatech \ Anti Mouse, mab TNFSF6 Source Rat \ 103-M495
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The tumor necrosis factor superfamily molecule LIGHT promotes keratinocyte activity and skin fibrosis
OriGene - Tnfsf11 (NM 011613) cDNA Clone
Stable Days: A DAY IN THE LIFE ... OF MOLLY, THE AMAZING HORSE!!
Tnfrsf1a (untagged) - Mouse tumor necrosis factor receptor superfamily, member 1a (cDNA clone MGC:6117 IMAGE:3585060), (10ug) -...
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anti-OPG antibody [13H21] | GeneTex
Molekulare Effekte der Immunmodulation mit einem anti-CD4-Antikörper
Gentaur Molecular :ATGen \ TNFSF11, 140-317aa, Human, His tag, E.coli \ ATGP1093
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Tumor necrosis factor receptor superfamily member 11A
Antigens, CD178 - Medical Dictionary online-medical-dictionary.org
OriGene - Tnfsf11 (NM 011613) Human ORF cDNA Clone
3N2L | LinkProt
CD40 Ligand/TNFSF5 Human anti-Human, DyLight 405, Clone: hu5c8 (Ruplizumab),
| Fisher Scientific
Apoptosis Database
Tumor necrosis factor receptor superfamily member 14
TRAIL R3, TNFRSF10C, Tumor necrosis factor receptor superfamily member 10C, DcR 1, Decoy Receptor 1, TRID or CD263 Antibody
CD302 (CLEC13A) Antibody, anti-human, REAfinity™ - Recombinant antibodies - MACS Antibodies - Products - Miltenyi Biotec -...
CD95 (FAS) Antibody, anti-human, REAfinity™ | Recombinant antibodies | MACS Antibodies | Products | Miltenyi Biotec | Lëtzebuerg
Recombinant Human CD30 [PRP-1369PRO]
Assay Solution. Human OX40/TNFRSF4 ELISA Kit
Plus it
Tumor Necrosis Factor Receptor Superfamily Member 1A (Tumor Necrosis Factor Receptor 1 or Tumor Necrosis Factor Receptor Type I...
Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for eiger signaling<...
PRINTS Search
GITR Ligand/TNFSF18 Research Products: Novus Biologicals
Cytokine receptor
... and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is ... Arimont A, Sun S, Smit MJ, Leurs R, de Esch IJ, de Graaf C (2017). "Structural Analysis of Chemokine Receptor-Ligand ...
CD30
"Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the ... Various types of CD30-positive B cell lymphomas Various types of CD30-positive T cell lymphomas CD30-positive cases of the NK ... CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma. CD30 is the target of the FDA approved ... Granados S, Hwang ST (Jun 2004). "Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases". The ...
Cytokine
... and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named (TNF ...
TRAF5
... has been shown to interact with: ASK1, CD134, CD30, CD40, RANK TNFRSF13B, and TNFRSF14. GRCh38: Ensembl release 89: ... a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics. 41 (1): 17- ... 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042-5. doi: ... 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042-5. doi: ...
Enteropathy-associated T-cell lymphoma
... the drug binds to the cell-membrane protein CD30 to deliver thereby the antimitotic aged into CD30-bearing target cells. This ... thereby blocking this protein from being activated by programmed death-ligand 1 (PD-L1). Many types of cancer cells increase ... A phase 1 study sponsored by the National Institutes of Health Clinical Center is recruiting patients that have CD30-expressing ... chimeric antigen receptor T cells that have been modified to target and destroy cells bearing CD30. A phase 1 study sponsored ...
Fibrin-associated diffuse large B-cell lymphoma
However, programmed death-ligand 1 (PD-L1), which acts to suppress the adaptive arm of the immune system, is overexpressed in ... CD30, CD45, CD79a, PAX5, and MUM1) and are infected with the EBV by their expression of this virus's proteins, e.g. EBNA2 and ...
LAG3
A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... "Soluble CD30 and lymphocyte activation gene-3 (CD223), as potential serological markers of T helper-type cytokine response ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4.[14] The protein negatively regulates ...
Tüümus - Vikipeedia
CD3 (diferentseerumise marker 3); CD4, CD8, CD30, CD120 (TNFR), CD150, CD152, CD279. ... Ligand[muuda , muuda lähteteksti]. Lipiidid[muuda , muuda lähteteksti]. *kolesterool. *sfingolipiid. Nukleiinhapped[muuda , ...
List of MeSH codes (D23)
... cd40 ligand MeSH D23.101.100.110.281 - cytokine receptor gp130 MeSH D23.101.100.110.283 - fms-like tyrosine kinase 3 MeSH ... cd30 MeSH D23.050.301.264.035.131 - antigens, cd31 MeSH D23.050.301.264.035.134 - antigens, cd34 MeSH D23.050.301.264.035.136 ... cd40 ligand MeSH D23.050.301.264.035.281 - cytokine receptor gp130 MeSH D23.050.301.264.035.282 - e-selectin MeSH D23.050. ... cd30 MeSH D23.101.100.110.131 - antigens, cd31 MeSH D23.101.100.110.134 - antigens, cd34 MeSH D23.101.100.110.136 - antigens, ...
Primary effusion lymphoma
... as well as activation and plasma cell marker proteins such as CD30, MUC1, CD38, syndecan 1, and IRF4/MUM1; they do not express ... overexpression of the P-selectin glycoprotein ligand-1 gene whose protein product promotes cell attachment to vascular ... the malignant cells in Type II PEL frequently express CD20 but often do not express CD30) and gene abnormalities (e.g. the ...
Primary cutaneous diffuse large B-cell lymphoma, leg type
The products of these two genes, programmed death-ligand 1 and programmed cell death 1 ligand 2, respectively, inhibit the anti ... The cells usually do not express CD5, CD10, CD30, or CD138. The neoplastic cells are also usually characterized as being of the ... monoclonal antibody that binds to programmed death-ligand 1 thereby blocking its ability to suppress immune responses) with or ...
Sialyl-Lewis X
For sialyl-Lewisx to bind to P-selectin, an O-linked glycan near the N-terminus of P-Selectin Glycoprotein Ligand-1 (PSGL-1) is ... Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter ... Trinchera, Marco; Aronica, Adele; Dall'Olio, Fabio (2017-02-23). "Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in ... The sialyl Lewis X determinant, E-selectin ligand carbohydrate structure, is constitutively expressed on granulocytes and ...
C-C chemokine receptor type 6
The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be ... 2002). "Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular ... ligand binding, and signaling". Biochemistry. 41 (26): 8332-41. doi:10.1021/bi025855y. PMID 12081481.. ... activation without changes in CCR6 expression or ligand binding". J. Immunol. 168 (10): 4871-80. doi:10.4049/jimmunol.168.10. ...
Tüümus - Vikipeedia
CD3 (diferentseerumise marker 3); CD4, CD8, CD30, CD120 (TNFR), CD150, CD152, CD279. ... LigandRedigeeri. LipiididRedigeeri. *kolesterool. *sfingolipiid. NukleiinhappedRedigeeri. Tüümuse desoksüribonukleiinhape ...
Interferon-alpha/beta receptor
Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. Ligand ... ligand-induced changes to internalization and trafficking of the receptor[8] and currently unappreciated differences to ligand- ... Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for ... Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the ...
Chimeric antigen receptor T cell
This can include cytokines, such is IL-2, IL-5, IL-12 and co‐stimulatory ligands. Adding a synthetic control mechanism to ... including CD30 in refractory Hodgkin's lymphoma; CD33, CD123, and FLT3 in acute myeloid leukemia (AML); and BCMA in multiple ... usually taking advantage of ligand/receptor pairs that normally bind to each other. Cytokines, innate immune receptors, TNF ...
CD154
... , also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells[5] and is a member of ... van Kooten C, Banchereau J (January 2000). "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. PMID 10647992.. ... CD40 ligand is primarily expressed on activated CD4+ T lymphocytes but is also found in a soluble form. While CD40L was ... Schönbeck U, Libby P (January 2001). "The CD40/CD154 receptor/ligand dyad". Cellular and Molecular Life Sciences. 58 (1): 4-43 ...
Anaplastic lymphoma kinase
No such ligands have been reported yet in zebrafish or other vertebrates. Following binding of the ligand, the full-length ... Yaakup H, Sagap I, Fadilah SA (October 2008). "Primary oesophageal Ki (CD30)-positive ALK+ anaplastic large cell lymphoma of T- ... The ligands of the human ALK/LTK receptors were identified in 2014: FAM150A (AUGβ) and FAM150B (AUGα), two small secreted ... The deduced amino acid sequences revealed that ALK was a novel receptor tyrosine kinase (RTK), having an extracellular ligand- ...
CD44
... is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix ... Oxley SM, Sackstein R (Nov 1994). "Detection of an L-selectin ligand on a hematopoietic progenitor cell line". Blood. 84 (10): ... Burdick MM, Chu JT, Godar S, Sackstein R (May 2006). "HCELL is the major E- and L-selectin ligand expressed on LS174T colon ... Sackstein R, Dimitroff CJ (Oct 2000). "A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N- ...
CD36 - Википедия
Hazen SL (June 2008). "Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity". J. Biol. Chem. 283 ...
G protein spregnuti receptori
On sadrži ligand-vezujući domen. Nakon vezivanja glutamata za mGluR receptor, N-terminalni rep podleže konformacionoj promeni ... CD30) • TNFRSF9 (CD137) ... I. Diversity of receptor-ligand interactions. J. Biol. Chem., ... Sedam transmembranskih heliksa formira šupljinu unutar ćelijske membrane koja služi kao ligand-vezujući domen, koji je često ... Pošto ta petlja sačinjava „poklopac" koji pokriva vrh ligand vezujućeg mesta, ova konformaciona razlika je dobra ilustracija ...
Interleukin 8 receptor, alpha
Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.[6] ...
Integrin beta 3
1l5g: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND ... 1tye: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for ... "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand ...
Neuropilin - Википедија, слободна енциклопедија
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... Još jedan ligand za neuropiline je VEGF, faktor rasta koji učestvuje u regulaciji angiogeneze. ...
TNFRSF18 - Википедия
... ligand in humans: NK cell/tumor cell interactions (англ.) // The FASEB Journal (англ.)русск. : journal. - Federation of ... and its ligand (GITRL) in atopic dermatitis (англ.) // Acta Derm. Venereol. : journal. - 2006. - Vol. 86, no. 5. - P. 393-398 ...
TNFRSF10A - Википедия
Kimberley F.C., Screaton G.R. Following a TRAIL: update on a ligand and its five receptors. (англ.) // Cell Res. (англ.)русск. ... Dörr J., Bechmann I., Waiczies S., et al. Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its ... Koyama S., Koike N., Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric ... Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (англ.) // J. Biol. Chem. : journal ...
CD8
The extracellular IgV-like domain of CD8-α interacts with the α3 portion of the Class I MHC molecule.[5] This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. The main recognition site is a flexible loop at the α3 domain of an MHC molecule. This was discovered by doing mutational analyses. The flexible α3 domain is located between residues 223 and 229 in the genome.[4] In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The cytoplasmic tails of the CD8 co-receptor interact with Lck (lymphocyte-specific protein tyrosine kinase). Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex which initiates a cascade of phosphorylation eventually leading to activation of transcription factors like NFAT, ...
Prostaglandin DP2 receptor
Ligands[edit]. Activating ligands[edit]. The following standard prostaglandins have the following relative affinities and ... Inhibiting ligands[edit]. The following compounds are selective receptor antagonists of and thereby inhibit the activation of ... Ligands that activate DP2 stimulate the in vitro chemotaxis (i.e. directed migration) of leukocytes active in mediating ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
TRAIL
In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces ... Bucur O, Ray S, Bucur MC, Almasan A (May 2006). "APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in ... Application of engineered ligands that have variable affinity for different death (DR4 and DR5) and decoy receptors (DCR1 and ... TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, ...
Afatinib
In March 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug.[13] Fall 2010 interim results suggested the drug extended progression-free survival threefold compared to placebo, but did not extend overall survival.[14] In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion.[15] In January 2015 a Phase III trial in people with NSCLC suggested the drug extended life expectancy in stage IV NSCLC adenocarcinoma with EGFR Mutation type del 19-positive tumors, compared to cisplatin-based chemotherapy by a year (33 months vs. 21 months).[16] It also shows strong activity against exon 18 mutations (particularly G719) and is currently the preferred EGFR-TKI therapy for exon 18 mutations (particularly G719x).[17][verification needed] Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from ...
Faktor aktivacije B-ćelija
4-1BB ligand • Faktor aktivacije B-ćelija • FAS ligand • Limfotoksin • OX40L • RANKL • TRAIL ... CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... BAFF je citokin iz TNF ligand familije. Ovaj citokin je ligand za receptore TNFRSF13B/TACI, TNFRSF17/BCMA, i TNFRSF13C/BAFFR. ... Faktor aktivacije B-ćelija, (BAFF) koji je takođe poznat kao faktor nekroze tumora ligand superfamilija član 13B, je protein ...
CD200 - Википедия
Gorczynski R.M. Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant ...
P-selectin
Ligand[edit]. The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all ... However, PSGL-1 is not specific for P-selectin, as it can also function as a ligand for both E- and L-selectin.[17] ... Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase- ... Vestweber D, Blanks JE (January 1999). "Mechanisms that regulate the function of the selectins and their ligands". Physiol. Rev ...
Nilotinib
... , sold under the brand name Tasigna, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome.[2] It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib.[2][3] It is taken by mouth.[3] Common side effects may include low platelets, low white blood cells, anemia, rashes, vomiting, diarrhea, and joint pains.[3] Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems.[3] It is not safe for use during pregnancy.[3] Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell.[3] Nilotinib was approved for medical use in the United States in 2007.[3] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[4] In the United Kingdom it costs the NHS £2,432.85 per month as of 2018.[5] In ...
Glikoprotein 130 - Википедија, слободна енциклопедија
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 4-1BB ligand • Kolesterilester transfer protein • Klasterin • Faktor stimulacije kolonije • Hemopeksin • Laktoferin • ...
Chemotherapy
Allen TM (Oct 2002). "Ligand-targeted therapeutics in anticancer therapy". Nature Reviews. Cancer. 2 (10): 750-63. PMID ... Active targeting uses biological molecules (antibodies, proteins, DNA and receptor ligands) to preferentially target the ...
CDH1 (gene)
Huber AH, Weis WI (May 2001). "The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand ...
CD97
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 2003). "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". J. Neuroimmunol. 132 (1-2): ... "The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)". J. Exp. Med. 184 (3): 1185-9. PMC 2192782. PMID ...
Erlotinib
... has shown a survival benefit in the treatment of lung cancer in phase III trials. The SATURN (Sequential Tarceva in Unresectable Non-small cell lung cancer) study found that erlotinib added to chemotherapy improved overall survival by 19%, and improved progression-free survival (PFS) by 29%, when compared to chemotherapy alone.[2][3] The U.S. Food and Drug Administration (FDA) has approved erlotinib for the treatment of locally advanced or metastatic non-small cell lung cancer that has failed at least one prior chemotherapy regimen. In November 2005, the FDA approved erlotinib in combination with gemcitabine for treatment of locally advanced, unresectable, or metastatic pancreatic cancer.[4] In lung cancer, erlotinib has been shown to be effective in patients with or without EGFR mutations, but appears to be more effective in patients with EGFR mutations.[5][6] Overall survival, progression-free survival and one-year survival are similar to standard second-line therapy (docetaxel or ...
CD97 - Википедија, слободна енциклопедија
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 2003). „Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". J. Neuroimmunol. 132 (1-2): ... Hamann J, Vogel B, van Schijndel GM, van Lier RA (1997). „The seven-span transmembrane receptor CD97 has a cellular ligand ( ...
Imatinib
PDB ligand id. STI: PDBe, RCSB PDB. LIGPLOT. 1iep. Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a ...
VCAM-1
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ...
CXCR5 - Википедия
Aust G., Sittig D., Becherer L., Anderegg U., Schütz A., Lamesch P., Schmücking E. The role of CXCR5 and its ligand CXCL13 in ... activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase ...
CD30 Ligand | Harvard Catalyst Profiles | Harvard Catalyst
"CD30 Ligand" by people in Harvard Catalyst Profiles by year, and whether "CD30 Ligand" was a major or minor topic of these ... Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. Leukemia. 1994 Dec; 8(12):2083-94. ... "CD30 Ligand" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "CD30 Ligand" by people in Profiles. ...
Characterization of the murine CD30 ligand (CD153) gene: Gene structure and expression<...
CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and is ... N2 - CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and ... AB - CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and ... abstract = "CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF ...
CD30 Ligand | Profiles RNS
"CD30 Ligand" by people in this website by year, and whether "CD30 Ligand" was a major or minor topic of these publications. ... "CD30 Ligand" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "CD30 Ligand" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "CD30 Ligand". ...
Recombinant Human CD30/TNFRSF8 Protein, CF 6126-CD-100: R&D Systems
Human CD30 / TNFRSF8 protein (6126-CD) is manufactured by R&D Systems, over 95% purity. Reproducible results in bioactivity ... Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling (15). ... CD30 antigen; CD30; CD30KI-1; CD30L receptor; cytokine receptor CD30; D1S166EKi-1; Ki-1 antigen; Lymphocyte activation antigen ... CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic ...
Buy Recombinant Human CD30 Ligand, Sf9 Protein (cyt-954)
Pig CD30 Ligand ELISA kit - E07C0335-192T B-Gene - Antibody-Antibodies
A sandwich ELISA for quantitative measurement of Porcine CD30 Ligand in samples from blood, plasma, serum, cell culture ... Product Pig CD30 Ligand ELISA kit From B-Gene - ... Pig CD30 Ligand ELISA kit E07C0335-48 B-Gene. 1 plate of 48 ... Pig CD30 Ligand ELISA kit. Supplier B-Gene · Catalog number: E07C0335-192T Price. 1270.00 EUR. Size. 192 tests ... A sandwich ELISA for quantitative measurement of Porcine CD30 Ligand in samples from blood, plasma, serum, cell culture ...
CD30 and its ligand: Possible role in regulation of teratoma stem cells
Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients.
Soluble CD30 (sCD30) is a suggested marker for kidney transplantation outcomes. We investigated whether sCD30 serum levels are ... Cd30 Ligand. A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically ... Summary of "Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients.". Soluble CD30 (sCD30) ... Antigens, Cd30. A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B ...
Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions
| European Journal of Histochemistry
... the distinctive expression of CD30/CD30- L in deciduas from physiological pregnancies may indicate that the CD30/CD30-L system ... Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions. European Journal of Histochemistry, 49(3), 285 ... of CD30 and CD30-L and their cellular pattern detected in the deciduas from spontaneous abortions suggest that the CD30/CD30-L ... Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions https://doi.org/10.4081/955 ...
Patent US7718400 - Methods of increasing lean tissue mass using OB protein compositions - Google Patents
CD30 ligand. US5514582. Jan 21, 1994. May 7, 1996. Genentech, Inc.. Recombinant DNA encoding hybrid immunoglobulins. ... Chimeric ligand/immunoglobulin molecules and their uses. US5428130. Dec 8, 1992. Jun 27, 1995. Genentech, Inc.. Hybrid ... Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding," J Biol Chem. (1992) 267: ... phylogenetic conservation of receptor-ligand interaction," vol. 42(2), 235-247 (1995). (Abstract.).. ...
Patent US7601814 - Reducing the immunogenicity of fusion proteins - Google Patents
CD30 ligand. US5514582. 21 Jan 1994. 7 May 1996. Genentech, Inc.. Recombinant DNA encoding hybrid immunoglobulins. ... of a ligand to a protein where it is already known that the ligand successfully binds to the protein and the protein/ligand ... The ligand, in the form of the consecutive amino acids of the peptide to be examined grafted onto a backbone from the backbone ... Thus, the ligand is a selected stretch of amino acids about 9 to 20 amino acids in length derived from a peptide, polypeptide ...
CD30/TNFRSF8 Antibody (CD30/412) [Alexa Fluor® 594] (NBP2-33196AF594): Novus Biologicals
CD30/412) [Alexa Fluor® 594]. Hodgkin & Reed-Sternberg Cell Marker. Validated: ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P. Tested ... Home » CD30/TNFRSF8 » CD30/TNFRSF8 Antibodies » CD30/TNFRSF8 Antibody (CD30/412) [Alexa Fluor® 594] ... CD30/TNFRSF8 Antibody (CD30/412) [Alexa Fluor® 594] Summary. Immunogen. A recombinant protein fragment specific to CD30 was ... Alternate Names for CD30/TNFRSF8 Antibody (CD30/412) [Alexa Fluor® 594]. *CD30 antigen ...
CD30 ligand could be a new therapeutic target for central nervous system autoimmunity<...
CD30 ligand could be a new therapeutic target for central nervous system autoimmunity. In: Clinical and Experimental ... CD30 ligand could be a new therapeutic target for central nervous system autoimmunity. / Shinoda, Koji; Yoshikai, Yasunobu. ... Shinoda K, Yoshikai Y. CD30 ligand could be a new therapeutic target for central nervous system autoimmunity. Clinical and ... Shinoda, K., & Yoshikai, Y. (2015). CD30 ligand could be a new therapeutic target for central nervous system autoimmunity. ...
CD30 ligand is a new therapeutic target for central nervous system autoimmunity<...
keywords = "CD30, CD30 ligand, CD30-Ig, EAE",. author = "Koji Shinoda and Xun Sun and Akiko Oyamada and Hisakata Yamada and ... N2 - The CD30 ligand (CD30L)/CD30 axis plays a critical role in Th1 and Th17 cell differentiation. However, the role in the ... AB - The CD30 ligand (CD30L)/CD30 axis plays a critical role in Th1 and Th17 cell differentiation. However, the role in the ... The CD30 ligand (CD30L)/CD30 axis plays a critical role in Th1 and Th17 cell differentiation. However, the role in the ...
Patente US7169904 - Immunocytokine sequences and uses thereof - Google Patentes
CD30 ligand. US5514582. 21 Ene 1994. 7 May 1996. Genentech, Inc.. Recombinant DNA encoding hybrid immunoglobulins. ... Chimeric ligand/immunoglobulin molecules and their uses. US5359035. 19 Oct 1992. 25 Oct 1994. Hoechst Aktiengesellschaft. ... Methods of stimulating hematopoietic cells with flt3-ligand. US5854205. 22 Oct 1996. 29 Dic 1998. The Childrens Medical Center ... Chang et al., (1996), "A Point Mutation in Interleukin-2 that Alters Ligand Internalization," Journal of Biological Chemistry, ...
Circulating Soluble CD30 and Future Risk of Lymphoma; Evidence from Two Prospective Studies in the General Population | Cancer...
Deciphering CD30 ligand biology and its role in humoral immunity. Immunology 2006;118:143-52. ... Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkins B cell lymphoma. Tumour Biol 2006;27:187- ... Circulating Soluble CD30 and Future Risk of Lymphoma; Evidence from Two Prospective Studies in the General Population. Roel ... A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma. Blood 2009;114:2730-2. ...
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology...
... is a receptor whose ligand defines an emerging family of cytokines with homology to TNF ... CD30 antigen, a marker for Hodgkins lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology ... The recombinant human ligand promotes the growth of CD3-stimulated T cells, but causes varied reactions, such as cell death, in ... Sequence homology to members of the tumor necrosis factor (TNF) receptor super family can be observed in CD30, which is a ...
Anti-Mouse CD30 SAFIRE Purified (Clone#: mCD30.1)
Tumour necrosis factor-like domain superfamily (IPR008983) | InterPro | EMBL-EBI
Tumour necrosis factor family protein, CD30 ligand type (IPR021185). *Complement C1q subcomponent subunit A (IPR037572) ... Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.. J. Biol. Chem. 277 6631-6 2002 ... 2 A crystal structure of an extracellular fragment of human CD40 ligand.. Structure 3 1031-9 1995 ... the RANK ligand (TNFSF11), which triggers osteoclastogenesis via the RANK receptor [PMID: 11733492]; and TALL-1 (soluble domain ...
KAKEN - Research Projects | Analyses of molecular bases of Hodgkin lymphoma by CD30-NF-kB pathway. (KAKENHI-PROJECT-14570162)
... independent of CD30 ligand. CD30 and TRAF proteins co-localized in H-RS cell lines and in lymph nodes of HL.. We identified ... Publications] Horie R, Ito K, Morisita Y et al.: Ligand independent signaling by overexpressed CD30 drives NF-kB activation in ... Publications] Horie R, Ito K, Morisita Y et al.: Ligand independent signaling by overexpressed CD30 drives NF-kB activation in ... Publications] Horie R, Ito K, Morisita Y et al.: Ligand independent signaling by overexpressed CD30 drives NF-κB activation in ...
Immune Checkpoint Proteins
Human CellExp™ CD30 Ligand / TNFSF8, Human Recombinant. Catalog #: P1462 , Datasheet Starting at: $115.00 ... Human CellExp™ CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant. Catalog #: P1127 , Datasheet ... Human CellExp™ CD40 Ligand / TNFSF5, Fc tag, Human Recombinant. Catalog #: P1175 , Datasheet ... Human CellExp™ GITR Ligand / TNFSF18 Fc Tag, Mouse recombinant. Catalog #: P1126 , Datasheet ...
Decoy Receptor 3 Increases Monocyte Adhesion to Endothelial Cells via NF-κB-Dependent Up-Regulation of Intercellular Adhesion...
Reverse signaling via CD30 ligand. J. Immunol. 157:3635.. OpenUrlAbstract. *↵ Suzuki, I., P. J. Fink. 1998. Maximal ... The dual functions of fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc. Natl. Acad. Sci. USA 97:1707. ... CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in secretion of immunomodulatory ... Fas ligand costimulates the in vivo proliferation of CD8+ T cells. J. Immunol. 165:5537. ...
CD30 Antibody, anti-mouse | Hybridomas | MACS Antibodies | Products | Miltenyi Biotec | USA
CD30 is expressed on the cell surface of activated T, B, and NK cells, and monocytes. The ligand for CD30 is CD153. CD153 co- ... Deletion of the murine CD30 gene revealed that CD30 may have a unique role in negative thymic selection following exposure to ... CD30 is a cell membrane protein. The cytoplasmic tail has been shown to interact with tumor necrosis factor receptor-associated ... Clone mCD30.1 recognizes mouse CD30, a 105 kDa type I transmembrane glycoprotein, also known as tumor necrosis factor receptor ...
OX40 Ligand/TNFSF4 Antibody (MM0505-8S23) [DyLight 405] (NBP2-11969V): Novus Biologicals
Mouse Monoclonal Anti-OX40 Ligand/TNFSF4 Antibody (MM0505-8S23) [DyLight 405]. Validated: Flow, IHC, IHC-Fr. Tested Reactivity ... Additional OX40 Ligand/TNFSF4 Products. OX40 Ligand/TNFSF4 NBP2-11969V * OX40 Ligand/TNFSF4 Antibodies ... Home » OX40 Ligand/TNFSF4 » OX40 Ligand/TNFSF4 Antibodies » OX40 Ligand/TNFSF4 Antibody (MM0505-8S23) [DyLight 405] ... Blogs on OX40 Ligand/TNFSF4. There are no specific blogs for OX40 Ligand/TNFSF4, but you can read our latest blog posts. ...
Human Effector Memory T Cells Express CD86: A Functional Role in Naive T Cell Priming | The Journal of Immunology
... they selectively express CD30, CD40-ligand, and CD70; and 3) in response to stimulation, most of them produce IFN-γ before ... c, CD30 expression is restricted to CD86+ T cells. Three weeks after stimulation, the expression of CD30 on CD86+ vs CD86− ... CD30 (Dako, Glostrup, Denmark), or -CD40-ligand (CD40-L) (Ancell, Bayport, MN) mAbs and biotin-labeled anti-CD86 mAb (clone ... because CD86 expression on T cells occurs earlier than CD30 expression (data not shown), CD30 expression could be induced ...
Tnfsf8 MGI Mouse Gene Detail - MGI:88328 - tumor necrosis factor (ligand) superfamily, member 8
Concurrent Hodgkin's Disease (Mixed Cellularity Type) and T-Cell Chronic Lymphocytic Leukemia/Prolymphocytic Leukemia |...
Pleiotropic effects of the CD30 ligand on CD30-expressing cells and lymphoma cell lines.Blood. 1994;83:2045-2056.PubMedGoogle ... CD30 ligand is frequently expressed in human hematopoietic malignancies of myeloid and lymphoid origin.Blood. 1997;89:2048-2059 ... Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.Blood. 1995;85:3378-3404.PubMed ... BerH2/CD30+, L26/PanB−, UCHL-1/CD45RO−, cyCD3−, CD4−, CD8−, CD20−, CD79a−, EMA−, EBER-1+, LMP-1+. Southern blot analysis of the ...
CD30 - Wikipedia
"Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the ... Various types of CD30-positive T cell lymphomas[11]. *CD30-positive cases of the NK cell lymphoma, extranodal NK/T-cell ... Granados S, Hwang ST (Jun 2004). "Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases". The ... CD30 has been shown to interact with TRAF5,[13] TRAF1,[14] TRAF2[13][14] and TRAF3.[14] ...
CD30/TNFRSF8 Products: R&D Systems
View our 4 CD30/TNFRSF8 products for your research including CD30/TNFRSF8 Primary Antibodies, Proteins and Enzymes, and cDNA ... The ligand for CD30 is CD30 Ligand/TNFSF8 (CD153), a member of the TNF superfamily. CD30 ligation by CD30 Ligand mediates ... CD30/TNFRSF8: Products. CD30/TNFRSF8 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. ...
US6680057B1 - Methods of treating autoimmune disease by administering interleukin-17 receptor
- Google Patents
Antibodies directed against CD30 ligand Legal Events. Date. Code. Title. Description. 2007-06-22. FPAY. Fee payment. Year of ... CD40 ligand polypeptide US7078494B1 (en) 2006-07-18. Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 ... A ligand (i.e., IL-17 or HVS-13) may also be used to prepare an affinity matrix for affinity purification of IL-17R. ... Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of ...
TNFSF8CD30LAntigensBindsAntibodiesHodgkin'sProteinLymphomaCD40 LigandRecombinant Human CD30 LigandCD154MurineSignal transductionOX40ExpressionProteinsReceptor superfamilyTumor necrosCytokineApoptosisSCD30GlycoproteinMonoclonal antibodyReceptorsD1S166EExtracellular domainCytoplasmicLymphomasAutoimmunityMoleculeSecretionHigh affinityInteractionsAntibody drug-conjugateDeath ligandAnti-CD30ProliferationBrentuximab vedotinApoptotic cellOverexpressionAnaplasticTherapeuticHumanInhibitorDifferentiationHodgkin
TNFSF85
- CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells (1, 5). (rndsystems.com)
- The ligand for CD30 is CD30 Ligand/TNFSF8 (CD153), a member of the TNF superfamily. (rndsystems.com)
- Cynomolgus CD30 Ligand / TNFSF8 derived in Human Cells. (creativebiomart.net)
- In our body, CD30 Ligand (CD153 Antigen) is a glycoprotein membrane-bound tumor necrosis family member, found primarily on activated T-lymphocytes that binds specifically to CD30 antigen, that may play a role in inflammation and immune regulation, encoded by the TNFSF8 gene . (wellnessadvocate.com)
- CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. (sinobiological.com)
CD30L12
- Interference of the CD30-CD30L pathway reduces atherosclerosis development. (harvard.edu)
- The CD30 ligand (CD30L)/CD30 axis plays a critical role in Th1 and Th17 cell differentiation. (elsevier.com)
- Invivo neutralization of CD30L by soluble murine CD30-Immunoglobulin fusion protein before disease onset or even after disease onset significantly ameliorated the clinical symptoms. (elsevier.com)
- These results indicate that CD30L/CD30 signaling is critically involved in antigen-specific CD4 T cell responses at both the induction and effector phase, thus could be a new target molecule for the treatment of central nervous system autoimmunity. (elsevier.com)
- The ligand for CD30 is CD30L (CD153). (nordicbiosite.com)
- The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. (nordicbiosite.com)
- CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. (sinobiological.com)
- 2009) Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseases. (sinobiological.com)
- 2001) CD30L up-regulates CD30 and IL-4 expression by T cells. (sinobiological.com)
- 2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. (sinobiological.com)
- 2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. (sinobiological.com)
- 2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. (sinobiological.com)
Antigens1
- Goldie-Cregan, LC, Croager, EJ & Abraham, L 2002, ' Characterization of the murine CD30 ligand (CD153) gene: Gene structure and expression ', Tissue Antigens , vol. 60, pp. 139-146. (edu.au)
Binds5
- A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (harvard.edu)
- The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily. (peprotech.com)
- Binds to human CD30 (Ki-1). (creativebiomart.net)
- The ligand binds cell surface receptors and triggers internalization. (aacrjournals.org)
- 2002) Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. (sinobiological.com)
Antibodies5
- This result was supported by the observation that blocking antibodies to OX40 and CD30 ligands also abrogated disease mediated by FoxP3-deficient T cells. (rupress.org)
- Anti-CD30 monoclonal antibodies have been investigated for the treatment of CD30-expressing malignancies in vitro and in vivo ( 10 , 12 - 18 ). (pnas.org)
- Several studies have shown that anti-CD30 monoclonal antibodies possessing signaling properties could inhibit the growth of ALCL cells, but very few of them were effective for HD cells ( 10 , 12 , 13 , 18 ). (pnas.org)
- Furthermore, although preclinical studies showed that treatment with anti-CD30 monoclonal antibodies prolonged the survival of ALCL-bearing mice significantly, compared with the mice in the control group, many of the mice in the treatment group still died of the disease ( 15 , 16 ). (pnas.org)
- Immunotoxins consist of cell-selective ligands (usually monoclonal antibodies, antibody fragments, or cytokines) linked covalently to modified peptide toxins. (aacrjournals.org)
Hodgkin's8
- Measured by its ability to block CD30 Ligand-induced IL-6 secretion by HDLM human Hodgkin's lymphoma cells. (rndsystems.com)
- In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. (novusbio.com)
- Sequence homology to members of the tumor necrosis factor (TNF) receptor super family can be observed in CD30, which is a surface marker for neoplastic cells of Hodgkin's lymphoma. (readabstracts.com)
- Overexpression of CD30 and constitutive NF-κB activation characterizes tumor cells of Hodgkin's lymphoma (HL), Hodgkin and Reed-Sternberg (H-RS) cells. (nii.ac.jp)
- Publications] Horie R, Higashihara M, Watanabe T.: 'The biology of Hodgkin's lymphpoma and CD30 signal transduction. (nii.ac.jp)
- [6] CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma . (wikipedia.org)
- Increased expression of CD30 is observed on some neoplasms including Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL), mediastinal B cell lymphoma, embryonal carcinoma, seminoma, and mesothelioma ( 2 - 7 ). (pnas.org)
- CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD). (sinobiological.com)
Protein12
- A recombinant protein fragment specific to CD30 was used as the immunogen for the C30/412 antibody. (novusbio.com)
- We identified TRAF protein aggregation in the cytoplasm of H-RS cells and also showed the involvement of TRAF protein aggregation in the signaling process of CD30. (nii.ac.jp)
- CD30 is a cell membrane protein. (miltenyibiotec.com)
- CD30 , also known as TNFRSF8 , is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker . (wikipedia.org)
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (creativebiomart.net)
- Clone REA1083 recognizes the mouse CD153 (CD30 ligand) antigen, a 40 kDa type II membrane protein belonging to the NGF/TNF superfamily. (miltenyibiotec.com)
- Murine CD30 cDNA predicts a protein of 498 amino acids with homology to the TNF receptor family of proteins characterized by repeated cysteine-rich motifs in the extracellular domain. (elsevier.com)
- Murine CD30 cDNA was shown to be functional through the production of a soluble murine Ig fusion protein (CD30-Ig) that was active in binding to cells that expressed CD30 ligand. (elsevier.com)
- Transient expression and quantitative binding studies show TRAIL-R3 to be a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. (rupress.org)
- It contains Human CD30 / TNFRSF8 capture antibody, Human CD30 / TNFRSF8 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CD30 / TNFRSF8 protein. (sinobiological.com)
- CD30 protein is expressed by activated, but not resting, T and B cells. (sinobiological.com)
- As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (sinobiological.com)
Lymphoma13
- Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. (harvard.edu)
- CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. (bioportfolio.com)
- The recombinant human ligand promotes the growth of CD3-stimulated T cells, but causes varied reactions, such as cell death, in many CD30+ lymphoma-derived clones. (readabstracts.com)
- Elevated circulating soluble CD30 (sCD30) has been previously associated with AIDS-related non-Hodgkin lymphoma (NHL) risk. (aacrjournals.org)
- Analyses of molecular bases of Hodgkin lymphoma by CD30-NF-kB pathway. (nii.ac.jp)
- The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kB activation in anaplastic large cell lymphoma. (nii.ac.jp)
- Publications] Horie R, Watanabe M, Ishida T, Koiwa T, Aizawa S, Itoh K, Higashihara M, Kadin ME, Watanahe T: 'The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-κB activation in anaplastic large cell lymphoma. (nii.ac.jp)
- CD30 is associated with anaplastic large cell lymphoma . (wikipedia.org)
- This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. (creativebiomart.net)
- Soluble CD30: a possible serum tumor marker for primary effusion lymphoma," Asian Pacific Journal of Cancer Prevention , vol. 13, no. 10, pp. 4939-4941, 2012. (hindawi.com)
- CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme," The Journal of Immunology , vol. 165, no. 12, pp. 6703-6709, 2000. (hindawi.com)
- In this study, we evaluated the therapeutic efficacy of an anti-CD30 antibody, HeFi-1, armed with 211 At in a leukemia (karpas299) model and with 90 Y in a lymphoma (SUDHL-1) model. (pnas.org)
- Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. (exbio.cz)
CD40 Ligand2
- 2 A crystal structure of an extracellular fragment of human CD40 ligand. (ebi.ac.uk)
- On and in our body's cells, CD40 Antigen is a surface glycoprotein expressed on all mature B lymphocytes, and a member of the tumor necrosis factor receptor superfamily with specificity for CD40 ligand , that plays an important role in B-cell development, growth, and differentiation. (wellnessadvocate.com)
Recombinant Human CD30 Ligand1
- The ED 50 for this effect is 1-5 μg/mL in the presence of 50 ng/mL of Recombinant Human CD30 Ligand (Catalog # 1028-CL). (rndsystems.com)
CD1541
- ligand polypeptide having a CD154 Domain III and a TNF.alpha. (patentgenius.com)
Murine5
- The cDNA cognate from the murine T cell clone 7B9 was expression cloned by using a chimeric probe with the extracellular region of CD30 linked to branched immunoglobulin heavy chains. (readabstracts.com)
- Deletion of the murine CD30 gene revealed that CD30 may have a unique role in negative thymic selection following exposure to antigen. (miltenyibiotec.com)
- 1996) Structure and expression of murine CD30 and its role in cytokine production. (miltenyibiotec.com)
- Murine CD30, although homologous to human CD30, has a 90 amino acid gap in an extracellular region that appears to be duplicated in human CD30. (elsevier.com)
- CD30-Ig also served as an immunogen for the production of hamster anti-mouse CD30 mAbs, which recognized both CD30 expressed by murine lymphocytes and CD30 expressed by cells transfected with murine CD30 cDNA. (elsevier.com)
Signal transduction1
- CD30-mediated signal transduction is capable of promoting cell proliferation and cell survival as well as antiproliferative effects and cell death depending on cell type and costimulatory effects ( 19 ). (pnas.org)
OX4015
- There are currently no images for OX40 Ligand/TNFSF4 Antibody (NBP2-11969V). (novusbio.com)
- This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human TNFSF4, also called OX40 ligand. (novusbio.com)
- Our previous studies have implicated signaling through the tumor necrosis family receptors OX40 and CD30 as critical for maintaining CD4 memory responses. (rupress.org)
- However, in the combined absence of OX40 and CD30, FoxP3-deficient mice develop normally and breed successfully. (rupress.org)
- Although the absence of OX40 plays the dominant role, FoxP3-deficient mice sufficient in CD30 but deficient in OX40 signals still eventually develop lethal disease. (rupress.org)
- These observations identify OX40 and CD30 signals as essential for the development of clinically relevant CD4-dependent autoimmunity and suggest that combination therapies that abrogate these signals might be used to treat established human autoimmune diseases. (rupress.org)
- We show in this paper that FoxP3 T reg cells are dispensable in mice deficient in OX40 and CD30 signals. (rupress.org)
- FoxP3-deficient mice lacking OX40 and CD30 develop and grow normally, fail to develop clinically relevant autoimmune disease, and have a normal lifespan. (rupress.org)
- We also show that blocking mAbs to OX40 and CD30 ligands abrogates development of FoxP3 KO disease. (rupress.org)
- To investigate the impact of abrogation of OX40 and CD30 signals on the development of autoimmunity in FoxP3 KO mice, male C57BL/6 mice, deficient in both OX40 and CD30 (double [d] KO), were crossed with females with a heterozygous null allele for the X-linked gene FoxP3 (FoxP3 het ). (rupress.org)
- As expected, ∼50% of male offspring heterozygous for expression of OX40 and CD30 (dKO het ) were FoxP3 deficient and developed lethal autoimmune disease at ∼4 wk ( Fig. 1 A ), characterized by weight loss ( Fig. 1 B ) and scurfy phenotype ( Fig. 1 C ). Because OX40 and CD30 are linked genetically, offspring have a high probability of inheriting deficiency in both genes as a haplotype. (rupress.org)
- 1996) OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. (miltenyibiotec.com)
- 1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. (miltenyibiotec.com)
- 1. A method for treating an inflammatory or an autoimmune condition, which comprises administering a therapeutically effective amount of an IL-1 inhibitor and an OX40 ligand inhibitor. (patentsencyclopedia.com)
- 9. The method of any one of claims 1 to 7, wherein the OX40 ligand inhibitor is an anti-OX40 ligand antibody. (patentsencyclopedia.com)
Expression16
- In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3, and CCL5 (5, 12). (rndsystems.com)
- In the present study, using immunohistochemistry, we studied the expression of CD30 and CD30-L in 35 deciduas obtained from women following elective abortion during normal physiological gestation and in 60 deciduas obtained from women after spontaneous abortion with or without signs of inflammation. (ejh.it)
- The reduced expression of CD30 and CD30-L and their cellular pattern detected in the deciduas from spontaneous abortions suggest that the CD30/CD30-L system is crucial for preventing abortions in the first trimester. (ejh.it)
- And furthermore, the distinctive expression of CD30/CD30- L in deciduas from physiological pregnancies may indicate that the CD30/CD30-L system exerts its main role in the first trimester. (ejh.it)
- We investigated apoptosis in distinct mucosal compartments, and the expression of Fas/Fas ligand and perforin in the inflamed and non- inflamed intestinal. (ebscohost.com)
- Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in systemic lupus erythematosus patients," Journal of Biomedicine and Biotechnology , vol. 2010, Article ID 569053, 8 pages, 2010. (hindawi.com)
- Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration," Clinical and Experimental Immunology , vol. 117, no. 2, pp. 291-297, 1999. (hindawi.com)
- Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a promising target for antibody-based therapy. (pnas.org)
- In contrast, CD30 expression in normal tissues is limited to activated T cells, activated B cells, select thymocytes, and some vascular beds ( 2 ). (pnas.org)
- Both HD and ALCL are characterized by the strong expression of CD30 on the malignant cell surfaces. (pnas.org)
- In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. (nordicbiosite.com)
- In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. (nordicbiosite.com)
- Expression of the negative T-cell regulator programmed death ligand 1 (PD-L1) seems to facilitate immune tolerance of various carcinomas. (aacrjournals.org)
- These include difficulties in immunotoxin production, rarity of high affinity, tumor selective ligands, heterogeneity of antigen/receptor expression on tumor cell surfaces, nontargeted toxicities, and immunogenicity. (aacrjournals.org)
- In anti-CD3-activated spleen cells, CD30 ligand is expressed primarily by CD4 + T cells, with peak expression at days 1 and 2, whereas CD30 is expressed primarily by CD8 + T cells, with peak expression on days 4 and 5. (elsevier.com)
- 2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. (sinobiological.com)
Proteins4
- CD30 and TRAF proteins co-localized in H-RS cell lines and in lymph nodes of HL. (nii.ac.jp)
- Thus, cytoplasmic aggregation of TRAF proteins appears to reflect constitutive CD30 signaling which is characteristic to H-RS cells. (nii.ac.jp)
- Our results showed that F3 may induce death receptor ligands to initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. (biomedcentral.com)
- These proteins elicit potent effector functions by binding target ligands (e.g. (doabooks.org)
Receptor superfamily7
- CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily (1, 2). (rndsystems.com)
- CD30 is a member of the tumour necrosis factor receptor superfamily with a restricted pattern of tissue distribution, limited to immune cells, decidual tissue, and human embryonal carcinoma: in common with other embryonal carcinoma markers, CD30 is found in foci of cells in a sub. (edu.au)
- Clone mCD30.1 recognizes mouse CD30, a 105 kDa type I transmembrane glycoprotein, also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8). (miltenyibiotec.com)
- CD30/TNFRSF8 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. (rndsystems.com)
- CD30 is a member of the TNF receptor superfamily. (pnas.org)
- CD30 is a member of the TNF receptor superfamily, which includes TNF-R1, TNF-R2, Fas-R, CD40, CD27, and TNF-related apoptosis-inducing ligand receptor ( 1 ). (pnas.org)
- CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. (nordicbiosite.com)
Tumor necros6
- Furthermore, UO126 potentiated the activity of apoliprotein 2/tumor necrosis factor-related apoptosis-inducing ligand (APO2L/TRAIL) and chemotherapy-induced cell death. (bloodjournal.org)
- 6 , 7 , 11 Furthermore, this activated pathway has been implicated in cancer cell resistance to chemotherapy and tumor necrosis factor-apoptosis inducing ligand (TRAIL/APO2L). (bloodjournal.org)
- The former have a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNF.alpha. (patentgenius.com)
- Immunoglobulin (Ig) superfamily, which are ubiquitously present throughout several cells and tissues of the vertebrate body Tumor necrosis factor receptor family, whose members share a cysteine-rich common extracellular binding domain, and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is named (TNF). (wikipedia.org)
- Tumor necrosis factor-related apoptosis inducing ligand (TRAIL, also called Apo2L or TNFSF10) is capable of inducing apoptosis in cancer cells but not in normal cells [ 29 ]. (biomedcentral.com)
- Full length Clone DNA of Rhesus tumor necrosis factor (ligand) superfamily, member 8 with N terminal Myc tag. (sinobiological.com)
Cytokine2
- CD30 signaling co‑stimulates antigen-induced Th0 and Th2 proliferation and cytokine secretion but favors a Th2-biased immune response (8). (rndsystems.com)
- These studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 signaling may be pivotal in the pattern of cytokine production by T cells. (elsevier.com)
Apoptosis3
- CD30 ligation by CD30 Ligand mediates pleiotropic effects, including cell proliferation, activation, differentiation and apoptosis. (rndsystems.com)
- 1 , 2 Under physiologic conditions, activation of the MAPK cascades by surface receptor/ligand interaction is tightly controlled and is involved in regulating cell proliferation, differentiation, and apoptosis. (bloodjournal.org)
- In rheumatoid arthritis soluble CD30 ligand is present at high levels and induces apoptosis of CD30 + T cells," Immunology Letters , vol. 161, no. 2, pp. 236-240, 2014. (hindawi.com)
SCD301
- Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. (nordicbiosite.com)
Glycoprotein4
- CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and is expressed primarily by activated T cells, B cells and monocytes. (edu.au)
- Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. (novusbio.com)
- CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. (novusbio.com)
- In addition to acting as the decoy receptor for Fas ligand (FasL) ( 13 ), DcR3 competes with HSV glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes (LIGHT) ( 14 ), and with TL1A ( 15 ). (jimmunol.org)
Monoclonal antibody1
- CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. (nordicbiosite.com)
Receptors3
- Activation of CD30, CD40, and receptor activator of nuclear kappaβ (RANK) receptors in HD cells by their respective ligands increased ERK phosphorylation above the basal level and promoted HD cell survival. (bloodjournal.org)
- Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. (doabooks.org)
- This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands. (doabooks.org)
D1S166E1
- TNFRSF8 is also known as CD30, Ki-1 and D1S166E. (sinobiological.com)
Extracellular domain2
- Mature human CD30 consists of a 361 amino acid (aa) extracellular domain (ECD) with six cysteine-rich repeats, a 28 aa transmembrane segment, and a 188 aa cytoplasmic domain (3). (rndsystems.com)
- Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. (ebi.ac.uk)
Cytoplasmic1
- Alternate splicing of human CD30 generates an isoform that includes only the C‑terminal 132 aa of the cytoplasmic domain. (rndsystems.com)
Lymphomas3
- In summary, radiolabeled HeFi-1 is very promising for the treatment of CD30-expressing leukemias and lymphomas, and the combination regimen of 211 At-HeFi-1 with unmodified HeFi-1 enhanced the therapeutic efficacy. (pnas.org)
- CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. (nordicbiosite.com)
- CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. (sinobiological.com)
Autoimmunity1
- Shinoda, K & Yoshikai, Y 2015, ' CD30 ligand could be a new therapeutic target for central nervous system autoimmunity ', Clinical and Experimental Neuroimmunology , vol. 6, no. 2, pp. 111-112. (elsevier.com)
Molecule3
- Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients. (bioportfolio.com)
- We structurally and functionally characterized the CD30 promoter, and identified JunB as a molecule that is involved in CD30 overexpression in H-RS cells. (nii.ac.jp)
- CD30 acts as a costimulatory molecule in thymic negative selection. (nordicbiosite.com)
Secretion1
- Fischer M, Harvima IT, Carvalho RF, Möller C, Naukkarinen A, Enblad G, Nilsson G: Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. (exbio.cz)
High affinity1
- Identification of high-affinity, adequately tumor-selective ligands has been challenging, particularly for epithelial cancers. (aacrjournals.org)
Interactions3
- Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Akt Signaling . (genecards.org)
- Thymus colonisation and thymocyte positioning are regulated by interactions between CCR7 and CCR9, and their respective ligands, CCL19/CCL21 and CCL25. (diva-portal.org)
- Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling. (sinobiological.com)
Antibody drug-conjugate1
- Dr. Eid said CheckMate 436 ( NCT02581631 ) was designed to "take advantage" of these characteristics by employing the anti-PD-1 checkpoint inhibitor nivolumab and the anti-CD30 antibody-drug conjugate brentuximab vedotin. (mdedge.com)
Death ligand1
- Programmed death ligand 1 (PD-L1) is expressed on antigen-presenting cells and inhibits activation of T cells through its receptor PD-1. (aacrjournals.org)
Anti-CD302
- Flow cytometry analysis (surface staining) of K562 cells added to human blood, with anti-CD30 (MEM-268) PE. (exbio.cz)
- Stimulation of CD30 by plate-bound anti-CD30 directly signaled for IL-5 but not IFN-γ production by CD30 + CTL lines. (elsevier.com)
Proliferation2
- The interaction between CD30 and CD153 enhance the proliferation of stimulated T cells but in the presence of the REA1083 antibody this effect is blocked. (miltenyibiotec.com)
- CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. (sinobiological.com)
Brentuximab vedotin1
- CD30 is the target of the FDA approved therapeutic brentuximab vedotin (Adcetris). (wikipedia.org)
Apoptotic cell1
- CD30 contributes to thymic negative selection by inducing the apoptotic cell death of CD4+CD8+ T cells (10, 11). (rndsystems.com)
Overexpression2
- We report that in H-RS cells overexpression of CD30 leads to self-aggregation, recruitment of TRAF2 and TRAF5, and NF-κB activation, independent of CD30 ligand. (nii.ac.jp)
- Prior research has shown that PMBCL is often characterized by overexpression of the PD-1 ligands PD-L1 and PD-L2, and most PMBCL expresses CD30. (mdedge.com)
Anaplastic1
- Type A is characterized by a a wedge-shaped diffuse dermal infiltrate containing scattered or clustered medium-sized to large pleomorphic or anaplastic lymphoid cells that are positive for CD30 (Figure 4). (renalandurologynews.com)
Therapeutic1
- Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases. (sinobiological.com)
Human2
- Within common regions of the ECD, human CD30 shares 53% and 49% aa sequence identity with mouse and rat CD30, respectively. (rndsystems.com)
- Immobilized Human CD30 Ligand, Mouse IgG2a Fc Tag, at 5 μg/mL (100 μL/well) can bind ab220597 with a linear range of 8-125 ng/mL. (abcam.com)
Inhibitor1
- Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling (15). (rndsystems.com)
Differentiation1
- CD30 plays a critical role in Th17 differentiation in mice. (nii.ac.jp)
Hodgkin3
- AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells'Am J Pathol. (nii.ac.jp)
- Ligand independent signaling by overexpressed CD30 drives NF-kB activation in Hodgkin and Reed-Sternberg cells. (nii.ac.jp)
- Publications] Watanabe M, Ogawa Y, Ito K, Higashihara M, Kadin ME, Watanabe T, Horie R: 'AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells'Am J Pathol. (nii.ac.jp)