Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Proteins prepared by recombinant DNA technology.
Methods for maintaining or growing CELLS in vitro.
The relative amounts of various components in the body, such as percentage of body fat.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The amount of force generated by MUSCLE CONTRACTION. Muscle strength can be measured during isometric, isotonic, or isokinetic contraction, either manually or using a device such as a MUSCLE STRENGTH DYNAMOMETER.
Bone loss due to osteoclastic activity.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Disorders caused by cellular or humoral immune responses primarily directed towards nervous system autoantigens. The immune response may be directed towards specific tissue components (e.g., myelin) and may be limited to the central nervous system (e.g., MULTIPLE SCLEROSIS) or the peripheral nervous system (e.g., GUILLAIN-BARRE SYNDROME).
Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
The provision of expert assistance in developing health planning programs, plans as technical materials, etc., as requested by Health Systems Agencies or other health planning organizations.
Antibodies produced by a single clone of cells.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
Computer systems or networks designed to provide radiographic interpretive information.
Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Adherence of cells to surfaces or to other cells.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signalling and activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES.
A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.
A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signaling and activation of MITOGEN-ACTIVATED PROTEIN KINASES.
A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 2 to inhibit APOPTOSIS.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells. (1/48)

Natural killer cells mediate spontaneously secretory/necrotic killing against rare leukemia cell lines and a nonsecretory/apoptotic killing against a large variety of tumor cell lines. The molecules involved in nonsecretory/apoptotic killing are largely undefined. In the present study, freshly isolated, nonactivated, human NK cells were shown to express TNF, lymphotoxin (LT)-alpha, LT-beta, Fas ligand (L), CD27L, CD30L, OX40L, 4-1BBL, and TNF-related apoptosis-inducing ligand (TRAIL), but not CD40L or nerve growth factor. Complementary receptors were demonstrated to be expressed on the cell surface of solid tumor cell lines susceptible to apoptotic killing mediated by NK cells. Individually applied, antagonists of TNF, LT-alpha1beta2, or FasL fully inhibited NK cell-mediated apoptotic killing of tumor cells. On the other hand, recombinant TNF, LT-alpha1beta2, or FasL applied individually or as pairs were not cytotoxic. In contrast, a mixture of the three ligands mediated significant apoptosis in tumor cells. These findings demonstrate that human NK cells constitutively express several of the TNF family ligands and induce apoptosis in tumor cells by simultaneous engagement of at least three of these cytotoxic molecules.  (+info)

CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression. (2/48)

Primary CD30(+) cutaneous T-cell lymphomas (CTCLs) represent a spectrum of non-Hodgkin's lymphomas (NHLs) that have been well defined at the clinical, histologic, and immunologic level. This group, which includes 2 main entities (large cell lymphoma and lymphomatoid papulosis [LyP]) and borderline cases, is characterized by the expression of CD30 antigen by neoplastic large cells at presentation, possible spontaneous regression of the skin lesions, and generally favorable clinical course. Although the functional relevance of CD30 and its natural ligand (CD30L) expression in most cases of NHL is presently undefined, previous studies indicate that CD30L is likely to mediate reduction of proliferation in CD30(+) anaplastic large-cell NHL. No information is currently available concerning the expression of CD30L in primary CD30(+) CTCLs. In this study, we investigated the immunophenotypic and genotypic expression of CD30 and CD30L in different developmental phases of skin lesions (growing v spontaneously regressing). By immunohistochemistry, CD30L expression was detected in regressing lesions only; by molecular analysis, the expression of CD30L was clearly higher in regressing lesions than in growing ones. CD30L, while expressed by some small lymphocytes, was most often coexpressed by CD30(+) neoplastic large cells, as demonstrated by 2-color immunofluorescence and by immunohistochemistry on paraffin sections. Taken together, these data suggest that CD30-CD30L interaction may play a role in the pathobiology of primary cutaneous CD30(+) lymphoproliferative disorders. In particular, CD30L (over)expression might have a major role in the mechanism of self-regression of skin lesions, the most distinctive clinical feature of this cutaneous lymphoma subtype.  (+info)

Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. (3/48)

Infection of inbred mouse strains with Leishmania major is a well characterized model for analysis of T helper (Th)1 and Th2 cell development in vivo. In this study, to address the role of costimulatory molecules CD27, CD30, 4-1BB, and OX40, which belong to the tumor necrosis factor receptor superfamily, in the development of Th1 and Th2 cells in vivo, we administered monoclonal antibody (mAb) against their ligands, CD70, CD30 ligand (L), 4-1BBL, and OX40L, to mice infected with L. major. Whereas anti-CD70, anti-CD30L, and anti-4-1BBL mAb exhibited no effect in either susceptible BALB/c or resistant C57BL/6 mice, the administration of anti-OX40L mAb abrogated progressive disease in BALB/c mice. Flow cytometric analysis indicated that OX40 was expressed on CD4(+) T cells and OX40L was expressed on CD11c(+) dendritic cells in the popliteal lymph nodes of L. major-infected BALB/c mice. In vitro stimulation of these CD4(+) T cells showed that anti-OX40L mAb treatment resulted in substantially reduced production of Th2 cytokines. Moreover, this change in cytokine levels was associated with reduced levels of anti-L. major immunoglobulin (Ig)G1 and serum IgE. These results indicate that anti-OX40L mAb abrogated progressive leishmaniasis in BALB/c mice by suppressing the development of Th2 responses, substantiating a critical role of OX40-OX40L interaction in Th2 development in vivo.  (+info)

Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. (4/48)

CD153 (CD30 ligand) is a member of the TNF ligand/cytokine family expressed on the surface of human B cells. Upon exposure to IL-4, a critical Ig class switch-inducing cytokine, Ag-activated T cells express CD30, the CD153 receptor. The observation that dysregulated IgG, IgA, and/or IgE production is often associated with up-regulation of T cell CD30 prompted us to test the hypothesis that engagement of B cell CD153 by T cell CD30 modulates Ig class switching. In this study, we show that IgD+ IgM+ B cells up-regulate CD153 in the presence of CD154 (CD40 ligand), IL-4, and B cell Ag receptor engagement. In these cells, CD153 engagement by an agonistic anti-CD153 mAb or T cell CD30 inhibits S mu-->Sgamma, Smu-->Salpha, and S mu-->Sepsilon class switch DNA recombination (CSR). This inhibition is associated with decreased TNFR-associated factor-2 binding to CD40, decreased NF-kappaB binding to the CD40-responsive element of the Cgamma3 promoter, decreased Igamma3-Cgamma3 germline gene transcription, and decreased expression of Ku70, Ku80, DNA protein kinase, switch-associated protein-70, and Msh2 CSR-associated transcripts. In addition, CD153 engagement inhibits IgG, IgA, and IgE production, and this effect is associated with reduced levels of B lymphocyte maturation protein-1 transcripts, and increased binding of B cell-specific activation protein to the Ig 3' enhancer. These findings suggest that CD30+ T cells modulate CSR as well as IgG, IgA, and IgE production by inducing reverse signaling through B cell CD153.  (+info)

CD30L up-regulates CD30 and IL-4 expression by T cells. (5/48)

CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L(+) neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.  (+info)

Human angiogenin fused to human CD30 ligand (Ang-CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma. (6/48)

A number of different immunotoxins composed of cell-specific targeting structures coupled to plant or bacterial toxins have increasingly been evaluated for immunotherapy. Because these foreign proteins are highly immunogenic in humans, we have developed a new CD30 ligand-based fusion toxin (Ang-CD30L) using the human RNase angiogenin. The completely human fusion gene was inserted into a pET-based expression plasmid. Transformed Escherichia coli BL21(DE3) were grown under osmotic stress conditions in the presence of compatible solutes. After isopropyl beta-D-thiogalactoside induction, the M(r) 37,000 His(10)-tagged Ang-CD30L was directed into the periplasmic space and functionally purified by a combination of metal ion affinity followed by enterokinase cleavage of the His(10)-Tag and molecular size chromatography. The characteristics of the recombinant protein were assessed by ELISA, flow cytometry, and toxicity assays showing specific activity against CD30(+) Hodgkin-derived cells. Specific binding activity of Ang-CD30L was verified by competition with anti-CD30 monoclonal antibody Ki-4 and commercially available CD30L-CD8 chimeric protein. Ang-CD30L showed RNase activity in vitro. The human recombinant immunotoxin showed significant toxicity toward several CD30-positive cell lines (HDLM-2, L1236, KM-H2, and L540Cy) and exhibited highest cytotoxicity against L540 cells (IC(50) = 8 ng/ml) as determined by cell proliferation assays. CD30 specificity was confirmed by competitive toxicity assays. This is the first report on the specific cytotoxicity of a recombinant completely human fusion toxin with possibly largely reduced immunogenicity for the treatment of CD30-positive malignancies.  (+info)

Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (7/48)

CD30-CD30 ligand (CD30L) signal transduction appears to protect against autoimmune diabetes by preventing expansion of autoreactive T cells and suppressing Th1-cytokine response. The purpose of this study was to determine whether CD30 or CD30L genes serve as a novel susceptibility gene for type 1 diabetes in humans. We screened CD30 and CD30L genes for polymorphisms in Japanese patients with type 1 diabetes and control subjects. Then, association studies were performed between each of the identified polymorphisms and type 1 diabetes. Direct-sequencing analysis of the CD30 and CD30L genes revealed four polymorphisms: one in the CD30 gene (-201G/A from the transcription start site), and three in the CD30L gene [CA repeat in the promoter, 276G/A in the exon 3, -73T/C in the intron 3 (IVS3 -73T/C)]. Association studies revealed no association between the CD30 and CD30L genes and type 1 diabetes in the whole population. In the female and male subpopulations, however, the frequency of (CA)(9) allele of the CD30L gene promoter or T allele of IVS3 -73T/C polymorphism in the CD30L gene was slightly higher in female patients with type 1 diabetes than that in control females. In conclusion, we could not find significant association between CD30 or CD30L genes and type 1 diabetes, but (CA)(9) allele in the promotor or T allele of -73T/C in intron 3 in CD30L gene might play a minor role in the pathogenesis of type 1 diabetes, only in the Japanese female population.  (+info)

Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus. (8/48)

CD30 is up-regulated in several human diseases and viral infections but its role in immune regulation is poorly understood. Here, we report the expression of a functional soluble CD30 homologue, viral CD30 (vCD30), encoded by ectromelia (mousepox) virus, a poxvirus that causes a severe disease related to human smallpox. We show that vCD30 is a 12-kD secreted protein that not only binds CD30L with high affinity and prevents its interaction with CD30, but it also induces reverse signaling in cells expressing CD30L. vCD30 blocked the generation of interferon gamma-producing cells in vitro and was a potent inhibitor of T helper cell (Th)1- but not Th2-mediated inflammation in vivo. The finding of a CD30 homologue encoded by ectromelia virus suggests a role for CD30 in antiviral defense. Characterization of the immunological properties of vCD30 has uncovered a role of CD30-CD30L interactions in the generation of inflammatory responses.  (+info)

Rollinghoff, M; Pfizenmaier, K; and Wagner, H, T-t cell interactions during cytotoxic t cell responses. IV. Murine lymphoid dendritic cells are powerful stimulators for helper t-lymphocytes. (1982). Subject Strain Bibliography 1982. 2724 ...
The article is a survey of the cellular interactions in the humoral response to antigen, the role of the major histocompatibility complex in the response, and the antibody response to antigens under the control of histocompatibility-linked immune response (Ir) genes. The article includes chapters on hapten-carrier effects and on the role of the major histocompatibility complex in T- and B-cell co-operation. Furthermore, macrophage-T-cell interactions, T-T cell interactions, and T-cell-macrophage-B-Cell interactions are discussed. There are 84 references.
CD40L / CD154 antibody [YMF323.6.2] (CD40 ligand) for FACS, WB. Anti-CD40L / CD154 mAb (GTX42386) is tested in Human, Rhesus Monkey, Cynomolgus monkey samples. 100% Ab-Assurance.
TY - JOUR. T1 - CD80 (B7-1) and CD86 (B7-2) antigens on house dust mite-specific T cells in atopic disease function through T-T cell interactions. AU - Nakada, Michihiro. AU - Nishizaki, Kazunori. AU - Yoshino, Tadashi. AU - Okano, Mitsuhiro. AU - Yamamoto, Takayoshi. AU - Masuda, Yu. AU - Ohta, Nobuo. AU - Akagi, Tadaatsu. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Background: CD80 (B7-1) and CD86 (B7-2) play an important role in antigen presentation to effector cells. Recent studies have demonstrated that these costimulatory molecules are also expressed on activated T cells. However, the functional role of CD80 and CD86 expressed on allergen-specific T cells in atopic diseases has not yet been clarified. Objective: We sought to determine the functional role of CD80 and CD86 expressed on allergen- specific T cells in atopic diseases. Methods: We assayed the expression of CD80 and CD86 on allergen-specific T-cell lines from patients with perennial allergic rhinitis stimulated by Dermatophagoides ...
Lümfoidkoe arengut mõjutavad rakud (lüh LTi, inglise lymphoid tissue inducer cells) on paljude selgroogsete loomade lümfoid(-immuun)süsteemi lümfirakkude tüüp. Lümfoidkoe arengut mõjutavad rakud kuuluvad ILC- (inglise innate lymphoid cells) rakkude perekonda. LTi-sid kirjeldati ligi 17 aastat tagasi ja neid seostatakse peamiselt kaasasündinud, aga ka omandatud immuunsusega. Lümfoidkoe arengut mõjutavate rakkude olemasolu, areng, anatoomia, morfoloogia, histoloogia, mutatsioonid, rakud ja molekulid ning apoptoos ja patoloogia võivad erineda nii liigiti, indiviiditi kui ka arenguastmeti. Fetaalsete lümfoidkoe arengut mõjutavate rakkude funktsiooniks on lümfoidkudede, sh lümfisõlmede ja Peyeri naastude, arengu tagamine pinnal paiknevate oluliste molekulide ekspressiooni läbi. Hiirtel tuvastatud fetaalsed lümfoidkoe arengut mõjutavad rakud võivad, olenevalt molekulidest, diferentseeruda antigeene esitlevateks rakkudeks (APC-deks), loomulikeks tappurrakkudeks, thyrocytus ...
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Non-Hodgkin lymphomas incidence has increased more than 70% in last 25 years. Aggressiveness, higher relapse rate, and treatment complications pose significant
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Tnfsf11 - Tnfsf11 (untagged) - Mouse tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11), (10ug) available for purchase from OriGene - Your Gene Company.
Hi Horse Pals ~ Erica sent us this beautiful story to share with all of our Horse Pals! We hope you enjoy it as much as we did! Thanks for sharing it, Erica! @raya and @very Ya gotta meet Molly... photos by Pam Kaster Meet Molly.Shes a grey speckled pony who was abandoned by her owners when Hurricane Katrina hit southern Louisiana . She spent weeks on her own before finally being rescued and taken to a farm where abandoned animals were stockpiled. While there, she was attacked by a pit bull terrier and almost died. Her gnawed right front leg became infected, and her vet went to LSU for help, but LSU was overwhelmed, and this pony was a welfare case. You know how that goes. But after surgeon Rustin Moore met Molly, he changed his mind.He saw how the pony was careful to lie down on different sides so she didnt seem to get sores, and how she allowed people to handle her.She protected her injured leg. She constantly shifted her weight and didnt overload her good leg. She was a smart pony with a serious
Tnfrsf1a (untagged) - Mouse tumor necrosis factor receptor superfamily, member 1a (cDNA clone MGC:6117 IMAGE:3585060), (10ug), 10 µg.
HTF Market Intelligence released a new research report of 41 pages on title Tumor Necrosis Factor Receptor Superfamily Member 6 (Apo 1 Antigen or Apoptosis Mediating Surface Antigen FAS or FASLG Receptor or TNFRSF6 or CD95 or FAS) - Pipeline Review, H1 2017 with detailed analysis, forecast and strategies. The study covers key regions and important players such as KAHR medical Ltd, Silence Therapeutics Plc
The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling pathways is expected to have therapeutic benefit for patients with various diseases, including cancer, autoimmunity, and infectious diseases. We review our current understanding of the structure and geometry of TNF superfamily ligands, receptors, and their interactions. A trimeric ligand and three receptors, each binding at the interface of two ligand monomers, form the basic unit of signaling. Clustering of multiple receptor subunits is necessary for efficient signaling. Current reports suggest that the receptors are prearranged on the cell surface in a nonsignaling, resting state in a large hexagonal structure of antiparallel dimers. Receptor activation requires ligand binding, and cross-linking antibodies can stabilize the receptors, thereby maintaining the active, signaling state. On the other hand, an ...
View mouse Tnfrsf18 Chr4:156026164-156028895 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
View mouse Tnfrsf13b Chr11:61126755-61149372 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
[65 Pages Report] Check for Discount on Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Pipeline Review, H1 2018 report by Global Markets Direct. Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or...
The tumor necrosis factor (TNF) superfamily refers to a superfamily of cytokines that can cause cell death (apoptosis). The first two members of the family to be identified were: Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia. The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers. Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide. Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10. Nineteen proteins have been identified as part of the TNF family on the basis of sequence, functional, and structural ...
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Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct isoforms have been described. GRCh38: Ensembl release 89: ENSG00000127863 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000060548 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19. Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). Isolation of novel and known genes from a human fetal cochlear ...
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The mouse monoclonal antibody recognizes human Integrin alpha L/CD11a. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS ...
OPG antibody [13H21] (tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)) for WB. Anti-OPG mAb (GTX53424) is tested in Mouse samples. 100% Ab-Assurance.
Das grundlegende Problem in der Transplantationsimmunologie ist es, die Langzeitakzeptanz eines fremden (allogen) Organs zu erreichen, ohne die sonstige Immunkompetenz des Empfängers zu beeinträchtigen. Die Induktion einer solchen spenderspezifischen Toleranz würde eine Alternative zum Langzeiteinsatz von Immunsuppressiva darstellen. Deswegen versucht man, während der Transplantation die Aktivierung der für die Abstoßung entscheidenden T-Helferzellen zu unterdrücken, bis eine Akzeptanz des Spenderorgans etabliert ist. Wichtig für eine Aktivierung der T-Zellen ist das für alle T-Helferzellen typische Zelloberflächenmolekül CD4. Antikörper gegen CD4 können in Tiermodellen eine Transplantattoleranz induzieren. Ein besonderes Interesse gilt der Charakterisierung der genauen Mechanismen dieser induzierten Transplantatakzeptanz, da diese noch wenig verstanden sind. Der von uns verwendete nicht-depletierende Maus-anti-Ratten-CD4mAk (RIB5/2) besitzt im allogenen Nierentransplantationsmodell ...
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|p|Tumor necrosis factor receptor superfamily, member 1A is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-kB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called periodic fever syndrome. Impaired receptor clearance is thought to be a mechanism of the disease.|/p|
RPB499Hu01, CD120A; P55; TBP1; FPF; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; P55-R; P60; Tumor necrosis factor receptor 1; Tumor necrosis factor-binding protein 1 | Products for research use only!
The TNFRSF11A gene encodes a member of the TNF receptor family and is therefore involved in regulation of immunen processes. Mutations cause autosomal recessive juvenile Paget disease, osteopetrosis, and dominant familial expansile osteolysis.. ...
A transmembrane protein belonging to the Tumor Necrosis Factor superfamily that was originally discovered on Cells of the lymphoid-myeloid lineage, including activated T-Lymphocytes and Natural Killer Cells. It plays an important Role in immune Homeostasis and Cell-mediated toxicity by binding to the fas Receptor and triggering Apoptosis ...
Tnfsf11 - Tnfsf11 (GFP-tagged) - Mouse tumor necrosis factor (ligand) superfamily member 11 (Tnfsf11), (10ug) available for purchase from OriGene - Your Gene Company.
Shop a large selection of products and learn more about CD40 Ligand/TNFSF5 Human anti-Human, DyLight 405, Clone: hu5c8 (Ruplizumab), 0.1 mL; DyLight™ 405.
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014 ...
Research proven purified goat polyclonal TRAIL R3, DcR 1 or CD263 antibody. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis. Designed for immunohistochemistry, western blotting, ELISA and related apllications. IHC image in product description.
Clone REA509 recognizes the human CD302 antigen, a single-pass type I membrane protein, which is also known as C-type lectin domain family 13 member A (CLEC13A) or DCL-1. The C-type lectin superfamily is a large group of proteins which are characterized by the presence of one or more C-type lectin-like domains (CTLDs). The superfamily is divided into 17 groups based on their phylogeny and domain organisation. Despite the presence of a highly conserved domain, C-type lectins are functionally diverse and have been implicated in various processes including cell adhesion, tissue integration and remodelling, platelet activation, complement activation, pathogen recognition, endocytosis, and phagocytosis. CD302 was identified as a genetic fusion partner of human CD205 (DEC-205) in Hodgkins lymphoma cell lines and is classified as a group XV C-type lectin. The receptor consists of a single extracellular CTLD, a short spacer followed by a transmembrane region, and a cytoplasmic tail containing a putative
Clone REA738 recognizes the human CD95 antigen, also known as Fas and Apo-1, which is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FasL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine
Synonyms: CD30, D1S166E, KI-1, Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, TNFRSF8.. ...
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels ...
Somatic mutations of the tumor suppressor tumor necrosis factor receptor superfamily member 14 (HVEM, encoded by TNFRSF14), which frequently occur in follicular lymphomas (FL), disrupt the interaction between HVEM and the immune checkpoint protein B and T lymphocyte associated (BTLA), resulting in the inhibition of T-cell immune responses. To elucidate the role of HVEM in germinal center (GC) lymphomagenesis, Boice, Salloum, Mourcin, and colleagues evaluated the interaction between HVEM and BTLA in FLs. Genomic and immunohistochemical analyses of human FLs identified HVEM mutations in 28% (40 of 141) of patient samples and the mutually exclusive loss of either HVEM or BTLA expression in 73% (145 of 198) of patient samples. Depletion of B cell-specific Hvem or Btla in a genetically engineered mouse model of FL resulted in enhanced lymphomagenesis in Hvem-deficient mice and Btla-deficient mice compared to control mice. Further, the morphology and activated status of the B-cell receptor (BCR) ...
Tumor Necrosis Factor Receptor Superfamily Member 1A (Tumor Necrosis Factor Receptor 1 or Tumor Necrosis Factor Receptor Type I or p55 or p60 or CD120a - Market research report and industry analysis - 12355963
TY - JOUR. T1 - Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for eiger signaling. AU - Kanda, Hiroshi. AU - Igaki, Tatsushi. AU - Kanuka, Hirotaka. AU - Yagi, Takeshi. AU - Miura, Masayuki. PY - 2002/8/9. Y1 - 2002/8/9. N2 - We identified Wengen, the first member of the Drosophila tumor necrosis factor receptor (TNFR) superfamily. Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in the extracellular domain, a hallmark of the TNFR superfamily. wengen mRNA is expressed at all stages of Drosophila development. The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference. In addition, Wengen and Eiger physically interacted with each other through their TNFR homology domain and TNF homology domain, respectively. These results suggest that Wengen can act as a component of a ...
WORKLIST ENTRIES (1): TNFACTORR14 View alignment Tumour necrosis factor receptor 14 signature Type of fingerprint: COMPOUND with 4 elements Links: PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3 PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6 PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9 PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12 PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01966 TNFACTORR16 PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19 PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25 PRINTS; PR01973 TNFACTORR27 PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B MIM; 602746 Creation date 23-JUN-2009 1. ARMITAGE, R. Tumor necrosis factor receptor superfamily members and their ligands. CURR.OPIN.IMMUNOL. 6 407-413 (1994). 2. BANNER D., DARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C., LOETSCHER, H. AND LESSLAUER, W. Crystal structure of the ...
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... and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named. ...
"Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the ... Various types of CD30-positive T cell lymphomas[11]. *CD30-positive cases of the NK cell lymphoma, extranodal NK/T-cell ... Granados S, Hwang ST (Jun 2004). "Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases". The ... CD30 has been shown to interact with TRAF5,[13] TRAF1,[14] TRAF2[13][14] and TRAF3.[14] ...
A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... "Soluble CD30 and lymphocyte activation gene-3 (CD223), as potential serological markers of T helper-type cytokine response ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4.[14] The protein negatively regulates ...
... cd40 ligand MeSH D23.101.100.110.281 - cytokine receptor gp130 MeSH D23.101.100.110.283 - fms-like tyrosine kinase 3 MeSH ... cd30 MeSH D23.050.301.264.035.131 - antigens, cd31 MeSH D23.050.301.264.035.134 - antigens, cd34 MeSH D23.050.301.264.035.136 ... cd40 ligand MeSH D23.050.301.264.035.281 - cytokine receptor gp130 MeSH D23.050.301.264.035.282 - e-selectin MeSH D23.050. ... cd30 MeSH D23.101.100.110.131 - antigens, cd31 MeSH D23.101.100.110.134 - antigens, cd34 MeSH D23.101.100.110.136 - antigens, ...
CD3 (diferentseerumise marker 3); CD4, CD8, CD30, CD120 (TNFR), CD150, CD152, CD279. ... Ligand[muuda , muuda lähteteksti]. Lipiidid[muuda , muuda lähteteksti]. *kolesterool. *sfingolipiid. Nukleiinhapped[muuda , ...
... as well as activation and plasma cell marker proteins such as CD30, MUC1, CD38, syndecan 1, and IRF4/MUM1; they do not express ... overexpression of the P-selectin glycoprotein ligand-1 gene whose protein product promotes cell attachment to vascular ... the malignant cells in Type II PEL frequently express CD20 but often do not express CD30) and gene abnormalities (e.g. the ...
The products of these two genes, programmed death-ligand 1 and programmed cell death 1 ligand 2, respectively, inhibit the anti ... The cells usually do not express CD5, CD10, CD30, or CD138. The neoplastic cells are also usually characterized as being of the ... monoclonal antibody that binds to programmed death-ligand 1 thereby blocking its ability to suppress immune responses) with or ...
The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be ... 2002). "Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular ... ligand binding, and signaling". Biochemistry. 41 (26): 8332-41. doi:10.1021/bi025855y. PMID 12081481.. ... activation without changes in CCR6 expression or ligand binding". J. Immunol. 168 (10): 4871-80. doi:10.4049/jimmunol.168.10. ...
This can include cytokines, such is IL-2, IL-5, IL-12 and co‐stimulatory ligands. Adding a synthetic control mechanism to ... including CD30 in refractory Hodgkin's lymphoma; CD33, CD123, and FLT3 in acute myeloid leukemia (AML); and BCMA in multiple ... usually taking advantage of ligand/receptor pairs that normally bind to each other. Cytokines, innate immune receptors, TNF ...
Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. Ligand ... ligand-induced changes to internalization and trafficking of the receptor[8] and currently unappreciated differences to ligand- ... Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for ... Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the ...
... , also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells[5] and is a member of ... van Kooten C, Banchereau J (January 2000). "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. PMID 10647992.. ... CD40 ligand is primarily expressed on activated CD4+ T lymphocytes but is also found in a soluble form. While CD40L was ... Schönbeck U, Libby P (January 2001). "The CD40/CD154 receptor/ligand dyad". Cellular and Molecular Life Sciences. 58 (1): 4-43 ...
... is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix ... Oxley SM, Sackstein R (Nov 1994). "Detection of an L-selectin ligand on a hematopoietic progenitor cell line". Blood. 84 (10): ... Burdick MM, Chu JT, Godar S, Sackstein R (May 2006). "HCELL is the major E- and L-selectin ligand expressed on LS174T colon ... Sackstein R, Dimitroff CJ (Oct 2000). "A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N- ...
Hazen SL (June 2008). "Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity". J. Biol. Chem. 283 ...
On sadrži ligand-vezujući domen. Nakon vezivanja glutamata za mGluR receptor, N-terminalni rep podleže konformacionoj promeni ... CD30) • TNFRSF9 (CD137) ... I. Diversity of receptor-ligand interactions. J. Biol. Chem., ... Sedam transmembranskih heliksa formira šupljinu unutar ćelijske membrane koja služi kao ligand-vezujući domen, koji je često ... Pošto ta petlja sačinjava „poklopac" koji pokriva vrh ligand vezujućeg mesta, ova konformaciona razlika je dobra ilustracija ...
Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.[6] ...
1l5g: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND ... 1tye: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for ... "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand ...
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... Još jedan ligand za neuropiline je VEGF, faktor rasta koji učestvuje u regulaciji angiogeneze. ...
... ligand in humans: NK cell/tumor cell interactions (англ.) // The FASEB Journal (англ.)русск. : journal. - Federation of ... and its ligand (GITRL) in atopic dermatitis (англ.) // Acta Derm. Venereol. : journal. - 2006. - Vol. 86, no. 5. - P. 393-398 ...
Kimberley F.C., Screaton G.R. Following a TRAIL: update on a ligand and its five receptors. (англ.) // Cell Res. (англ.)русск. ... Dörr J., Bechmann I., Waiczies S., et al. Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its ... Koyama S., Koike N., Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric ... Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (англ.) // J. Biol. Chem. : journal ...
The extracellular IgV-like domain of CD8-α interacts with the α3 portion of the Class I MHC molecule.[5] This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. The main recognition site is a flexible loop at the α3 domain of an MHC molecule. This was discovered by doing mutational analyses. The flexible α3 domain is located between residues 223 and 229 in the genome.[4] In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The cytoplasmic tails of the CD8 co-receptor interact with Lck (lymphocyte-specific protein tyrosine kinase). Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex which initiates a cascade of phosphorylation eventually leading to activation of transcription factors like NFAT, ...
Ligands[edit]. Activating ligands[edit]. The following standard prostaglandins have the following relative affinities and ... Inhibiting ligands[edit]. The following compounds are selective receptor antagonists of and thereby inhibit the activation of ... Ligands that activate DP2 stimulate the in vitro chemotaxis (i.e. directed migration) of leukocytes active in mediating ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces ... Bucur O, Ray S, Bucur MC, Almasan A (May 2006). "APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in ... Application of engineered ligands that have variable affinity for different death (DR4 and DR5) and decoy receptors (DCR1 and ... TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, ...
Zeitlmann L, Sirim P, Kremmer E, Kolanus W (March 2001). "Cloning of ACP33 as a novel intracellular ligand of CD4". The Journal ...
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 2003). „Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". J. Neuroimmunol. 132 (1-2): ... Hamann J, Vogel B, van Schijndel GM, van Lier RA (1997). „The seven-span transmembrane receptor CD97 has a cellular ligand ( ...
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding.". J. Cell. Biochem. 55 (3): 380-8. PMID ... 1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral ...
Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (2000). "Novel mode of ligand binding by the SH2 ... "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments ...
Aust G., Sittig D., Becherer L., Anderegg U., Schütz A., Lamesch P., Schmücking E. The role of CXCR5 and its ligand CXCL13 in ... activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase ...
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 2003). "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". J. Neuroimmunol. 132 (1-2): ... "The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)". J. Exp. Med. 184 (3): 1185-9. PMC 2192782. PMID ...
Ligands[edit]. Decay accelerating factor (DAF/CD55), a regulatory protein of the complement cascade, interacts with the first ... Mice lacking CD97 or its ligand CD55 have twice as many granulocytes as wild-type mice possibly due to enhanced granulopoiesis. ... The expression of CD97 on macrophage and the abundant presence of its ligand CD55 on fibroblast-like synovial cells suggest ... "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". Journal of Neuroimmunology. 132 (1-2 ...
Ligand[edit]. The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all ... However, PSGL-1 is not specific for P-selectin, as it can also function as a ligand for both E- and L-selectin.[17] ... Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase- ... Vestweber D, Blanks JE (January 1999). "Mechanisms that regulate the function of the selectins and their ligands". Physiol. Rev ...
In March 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug.[13] Fall 2010 interim results suggested the drug extended progression-free survival threefold compared to placebo, but did not extend overall survival.[14] In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion.[15] In January 2015 a Phase III trial in people with NSCLC suggested the drug extended life expectancy in stage IV NSCLC adenocarcinoma with EGFR Mutation type del 19-positive tumors, compared to cisplatin-based chemotherapy by a year (33 months vs. 21 months).[16] It also shows strong activity against exon 18 mutations (particularly G719) and is currently the preferred EGFR-TKI therapy for exon 18 mutations (particularly G719x).[17][verification needed] Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from ...
4-1BB ligand • Faktor aktivacije B-ćelija • FAS ligand • Limfotoksin • OX40L • RANKL • TRAIL ... CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... BAFF je citokin iz TNF ligand familije. Ovaj citokin je ligand za receptore TNFRSF13B/TACI, TNFRSF17/BCMA, i TNFRSF13C/BAFFR. ... Faktor aktivacije B-ćelija, (BAFF) koji je takođe poznat kao faktor nekroze tumora ligand superfamilija član 13B, je protein ...
Gorczynski R.M. Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant ...
... , sold under the brand name Tasigna, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome.[2] It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib.[2][3] It is taken by mouth.[3] Common side effects may include low platelets, low white blood cells, anemia, rashes, vomiting, diarrhea, and joint pains.[3] Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems.[3] It is not safe for use during pregnancy.[3] Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell.[3] Nilotinib was approved for medical use in the United States in 2007.[3] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[4] In the United Kingdom it costs the NHS £2,432.85 per month as of 2018.[5] In ...
CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • ... 4-1BB ligand • Kolesterilester transfer protein • Klasterin • Faktor stimulacije kolonije • Hemopeksin • Laktoferin • ...
Allen TM (Oct 2002). "Ligand-targeted therapeutics in anticancer therapy". Nature Reviews. Cancer. 2 (10): 750-63. PMID ... Active targeting uses biological molecules (antibodies, proteins, DNA and receptor ligands) to preferentially target the ...
Huber AH, Weis WI (May 2001). "The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand ...
... has shown a survival benefit in the treatment of lung cancer in phase III trials. The SATURN (Sequential Tarceva in Unresectable Non-small cell lung cancer) study found that erlotinib added to chemotherapy improved overall survival by 19%, and improved progression-free survival (PFS) by 29%, when compared to chemotherapy alone.[2][3] The U.S. Food and Drug Administration (FDA) has approved erlotinib for the treatment of locally advanced or metastatic non-small cell lung cancer that has failed at least one prior chemotherapy regimen. In November 2005, the FDA approved erlotinib in combination with gemcitabine for treatment of locally advanced, unresectable, or metastatic pancreatic cancer.[4] In lung cancer, erlotinib has been shown to be effective in patients with or without EGFR mutations, but appears to be more effective in patients with EGFR mutations.[5][6] Overall survival, progression-free survival and one-year survival are similar to standard second-line therapy (docetaxel or ...
PDB ligand id. STI: PDBe, RCSB PDB. LIGPLOT. 1iep. Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a ...
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ...
"CD30 Ligand" by people in Harvard Catalyst Profiles by year, and whether "CD30 Ligand" was a major or minor topic of these ... Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. Leukemia. 1994 Dec; 8(12):2083-94. ... "CD30 Ligand" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "CD30 Ligand" by people in Profiles. ...
CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and is ... N2 - CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and ... AB - CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and ... abstract = "CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF ...
"CD30 Ligand" by people in this website by year, and whether "CD30 Ligand" was a major or minor topic of these publications. ... "CD30 Ligand" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "CD30 Ligand" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "CD30 Ligand". ...
Recombinant Human CD30 Ligand, Sf9 from Prospec cat# cyt-954. ProteoGenix provides you the best Cytokines and growth factors ... Proteins>Cytokines and growth factors proteins>Recombinant Human CD30 Ligand, Sf9 Protein ...
Human CD30 / TNFRSF8 protein (6126-CD) is manufactured by R&D Systems, over 95% purity. Reproducible results in bioactivity ... Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling (15). ... CD30 antigen; CD30; CD30KI-1; CD30L receptor; cytokine receptor CD30; D1S166EKi-1; Ki-1 antigen; Lymphocyte activation antigen ... CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic ...
A sandwich ELISA for quantitative measurement of Porcine CD30 Ligand in samples from blood, plasma, serum, cell culture ... Product Pig CD30 Ligand ELISA kit From B-Gene - ... Pig CD30 Ligand ELISA kit E07C0335-48 B-Gene. 1 plate of 48 ... Pig CD30 Ligand ELISA kit. Supplier B-Gene · Catalog number: E07C0335-192T Price. 1270.00 EUR. Size. 192 tests ... A sandwich ELISA for quantitative measurement of Porcine CD30 Ligand in samples from blood, plasma, serum, cell culture ...
Soluble CD30 (sCD30) is a suggested marker for kidney transplantation outcomes. We investigated whether sCD30 serum levels are ... Cd30 Ligand. A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically ... Summary of "Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients.". Soluble CD30 (sCD30) ... Antigens, Cd30. A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B ...
... the distinctive expression of CD30/CD30- L in deciduas from physiological pregnancies may indicate that the CD30/CD30-L system ... Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions. European Journal of Histochemistry, 49(3), 285 ... of CD30 and CD30-L and their cellular pattern detected in the deciduas from spontaneous abortions suggest that the CD30/CD30-L ... Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions https://doi.org/10.4081/955 ...
CD30 ligand. US5514582. Jan 21, 1994. May 7, 1996. Genentech, Inc.. Recombinant DNA encoding hybrid immunoglobulins. ... Chimeric ligand/immunoglobulin molecules and their uses. US5428130. Dec 8, 1992. Jun 27, 1995. Genentech, Inc.. Hybrid ... Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding," J Biol Chem. (1992) 267: ... phylogenetic conservation of receptor-ligand interaction," vol. 42(2), 235-247 (1995). (Abstract.).. ...
CD30 ligand. US5514582. 21 Jan 1994. 7 May 1996. Genentech, Inc.. Recombinant DNA encoding hybrid immunoglobulins. ... of a ligand to a protein where it is already known that the ligand successfully binds to the protein and the protein/ligand ... The ligand, in the form of the consecutive amino acids of the peptide to be examined grafted onto a backbone from the backbone ... Thus, the ligand is a selected stretch of amino acids about 9 to 20 amino acids in length derived from a peptide, polypeptide ...
CD30 ligand. US5514582. 21 Ene 1994. 7 May 1996. Genentech, Inc.. Recombinant DNA encoding hybrid immunoglobulins. ... Chimeric ligand/immunoglobulin molecules and their uses. US5359035. 19 Oct 1992. 25 Oct 1994. Hoechst Aktiengesellschaft. ... Methods of stimulating hematopoietic cells with flt3-ligand. US5854205. 22 Oct 1996. 29 Dic 1998. The Childrens Medical Center ... Chang et al., (1996), "A Point Mutation in Interleukin-2 that Alters Ligand Internalization," Journal of Biological Chemistry, ...
Deciphering CD30 ligand biology and its role in humoral immunity. Immunology 2006;118:143-52. ... Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkins B cell lymphoma. Tumour Biol 2006;27:187- ... Circulating Soluble CD30 and Future Risk of Lymphoma; Evidence from Two Prospective Studies in the General Population. Roel ... A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma. Blood 2009;114:2730-2. ...
... is a receptor whose ligand defines an emerging family of cytokines with homology to TNF ... CD30 antigen, a marker for Hodgkins lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology ... The recombinant human ligand promotes the growth of CD3-stimulated T cells, but causes varied reactions, such as cell death, in ... Sequence homology to members of the tumor necrosis factor (TNF) receptor super family can be observed in CD30, which is a ...
Tumour necrosis factor family protein, CD30 ligand type (IPR021185). *Complement C1q subcomponent subunit A (IPR037572) ... Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.. J. Biol. Chem. 277 6631-6 2002 ... 2 A crystal structure of an extracellular fragment of human CD40 ligand.. Structure 3 1031-9 1995 ... the RANK ligand (TNFSF11), which triggers osteoclastogenesis via the RANK receptor [PMID: 11733492]; and TALL-1 (soluble domain ...
The ligand for CD30 is CD153. It has been suggested that the molecule plays a role in the protection against autoimmunity and ... The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) ...
Human CellExp™ CD30 Ligand / TNFSF8, Human Recombinant. Catalog #: P1462 , Datasheet Starting at: $115.00 ... Human CellExp™ CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant. Catalog #: P1127 , Datasheet ... Human CellExp™ CD40 Ligand / TNFSF5, Fc tag, Human Recombinant. Catalog #: P1175 , Datasheet ... Human CellExp™ GITR Ligand / TNFSF18 Fc Tag, Mouse recombinant. Catalog #: P1126 , Datasheet ...
Reverse signaling via CD30 ligand. J. Immunol. 157:3635.. OpenUrlAbstract. *↵ Suzuki, I., P. J. Fink. 1998. Maximal ... The dual functions of fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc. Natl. Acad. Sci. USA 97:1707. ... CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in secretion of immunomodulatory ... Fas ligand costimulates the in vivo proliferation of CD8+ T cells. J. Immunol. 165:5537. ...
... independent of CD30 ligand. CD30 and TRAF proteins co-localized in H-RS cell lines and in lymph nodes of HL.. We identified ... Publications] Horie R, Ito K, Morisita Y et al.: Ligand independent signaling by overexpressed CD30 drives NF-kB activation in ... Publications] Horie R, Ito K, Morisita Y et al.: Ligand independent signaling by overexpressed CD30 drives NF-kB activation in ... Publications] Horie R, Ito K, Morisita Y et al.: Ligand independent signaling by overexpressed CD30 drives NF-κB activation in ...
Mouse Monoclonal Anti-OX40 Ligand/TNFSF4 Antibody (MM0505-8S23) [DyLight 405]. Validated: Flow, IHC, IHC-Fr. Tested Reactivity ... Additional OX40 Ligand/TNFSF4 Products. OX40 Ligand/TNFSF4 NBP2-11969V * OX40 Ligand/TNFSF4 Antibodies ... Home » OX40 Ligand/TNFSF4 » OX40 Ligand/TNFSF4 Antibodies » OX40 Ligand/TNFSF4 Antibody (MM0505-8S23) [DyLight 405] ... Blogs on OX40 Ligand/TNFSF4. There are no specific blogs for OX40 Ligand/TNFSF4, but you can read our latest blog posts. ...
... they selectively express CD30, CD40-ligand, and CD70; and 3) in response to stimulation, most of them produce IFN-γ before ... c, CD30 expression is restricted to CD86+ T cells. Three weeks after stimulation, the expression of CD30 on CD86+ vs CD86− ... CD30 (Dako, Glostrup, Denmark), or -CD40-ligand (CD40-L) (Ancell, Bayport, MN) mAbs and biotin-labeled anti-CD86 mAb (clone ... because CD86 expression on T cells occurs earlier than CD30 expression (data not shown), CD30 expression could be induced ...
J:12921 Smith CA, et al., CD30 antigen, a marker for Hodgkins lymphoma, is a receptor whose ligand defines an emerging family ... J:200593 Guo Y, et al., CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing gammadelta T Cells in ...
Pleiotropic effects of the CD30 ligand on CD30-expressing cells and lymphoma cell lines.Blood. 1994;83:2045-2056.PubMedGoogle ... CD30 ligand is frequently expressed in human hematopoietic malignancies of myeloid and lymphoid origin.Blood. 1997;89:2048-2059 ... Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.Blood. 1995;85:3378-3404.PubMed ... BerH2/CD30+, L26/PanB−, UCHL-1/CD45RO−, cyCD3−, CD4−, CD8−, CD20−, CD79a−, EMA−, EBER-1+, LMP-1+. Southern blot analysis of the ...
"Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the ... Various types of CD30-positive T cell lymphomas[11]. *CD30-positive cases of the NK cell lymphoma, extranodal NK/T-cell ... Granados S, Hwang ST (Jun 2004). "Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases". The ... CD30 has been shown to interact with TRAF5,[13] TRAF1,[14] TRAF2[13][14] and TRAF3.[14] ...
View our 4 CD30/TNFRSF8 products for your research including CD30/TNFRSF8 Primary Antibodies, Proteins and Enzymes, and cDNA ... The ligand for CD30 is CD30 Ligand/TNFSF8 (CD153), a member of the TNF superfamily. CD30 ligation by CD30 Ligand mediates ... CD30/TNFRSF8: Products. CD30/TNFRSF8 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. ...
Antibodies directed against CD30 ligand Legal Events. Date. Code. Title. Description. 2007-06-22. FPAY. Fee payment. Year of ... CD40 ligand polypeptide US7078494B1 (en) 2006-07-18. Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 ... A ligand (i.e., IL-17 or HVS-13) may also be used to prepare an affinity matrix for affinity purification of IL-17R. ... Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of ...
Homo sapiens CD30 ligand mRNA. L11353. Human moesin-ezrin-radixin-like protein mRNA. ... Aptamer base technique for ligand identification US20030077595A1 (en) 2003-04-24. Methods and compositions for enhancing ... Methods and compositions for detecting binding of ligand pair using non-fluorescent label ...
Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. ... Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. ... Mast cells were found to be the predominant CD30 ligand-positive (CD30L-positive) cell in the chronic inflammatory skin ... CD30 induced a de novo synthesis and secretion of the chemokines IL-8, macrophage inflammatory protein-1α (MIP-1α), and MIP-1β ...
Journal Article] CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.2010. *. Author(s). Sun, X., Yamada, H ... Journal Article] CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses./CD30 ...
... was incubated with 1 μg/mL of CD30 ligand (CD30L), CD40 ligand (CD40L), and RANK ligand (RANKL) for 1 to 6 hours. Total ERK and ... Recombinant CD30 ligand and CD40 ligand share common biological activities on Hodgkin and Reed-Sternberg cells. Eur J Immunol. ... Thus, we studied the effects of CD30 ligand (CD30L) and CD40 ligand (CD40L) on the MEK/ERK pathway in HD cell lines. As ... Recombinant human RANK ligand (RANKL, TNF-related activation-induced cytokine [TRANCE]), CD40 ligand (CD40L, CD154), CD30 ...
We also show that blocking mAbs to OX40 and CD30 ligands abrogates development of FoxP3KO disease. This study highlights the ... and were crossed with CD30KOOX40KO (dKO) or mice deficient in OX40 (OX40KO) or CD30 (CD30KO). ... After transfer, mice received either twice weekly injections of blocking mAbs to OX40 and CD30 ligands (Akiba et al., 2000) or ... Molecular phylogeny shows that the TNF ligands for OX40 and CD30 evolved late (Glenney and Wiens, 2007), as orthologs of these ...
  • CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells (1, 5). (rndsystems.com)
  • The ligand for CD30 is CD30 Ligand/TNFSF8 (CD153), a member of the TNF superfamily. (rndsystems.com)
  • Cynomolgus CD30 Ligand / TNFSF8 derived in Human Cells. (creativebiomart.net)
  • In our body, CD30 Ligand (CD153 Antigen) is a glycoprotein membrane-bound tumor necrosis family member, found primarily on activated T-lymphocytes that binds specifically to CD30 antigen, that may play a role in inflammation and immune regulation, encoded by the TNFSF8 gene . (wellnessadvocate.com)
  • CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. (sinobiological.com)
  • TNFSF8: ProductsCD30 Ligand, As involved as TNFSF8, has a download II picture constitution generating to the TNF Goodreads. (marceichler.de)
  • Interference of the CD30-CD30L pathway reduces atherosclerosis development. (harvard.edu)
  • The ligand for CD30 is CD30L (CD153). (nordicbiosite.com)
  • The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. (nordicbiosite.com)
  • 2001) CD30L up-regulates CD30 and IL-4 expression by T cells. (sinobiological.com)
  • 2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. (sinobiological.com)
  • 2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. (sinobiological.com)
  • 2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. (sinobiological.com)
  • CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. (sinobiological.com)
  • 2009) Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseases. (sinobiological.com)
  • rh CD30/TNFRSF8 (Catalog # 813-CD) is also available with a Fc and a His tag! (rndsystems.com)
  • CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily (1, 2). (rndsystems.com)
  • CD30 , also known as TNFRSF8 , is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker . (wikipedia.org)
  • CD30/TNFRSF8 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. (rndsystems.com)
  • CD30/TNFRSF8 " has 4 results in Products. (rndsystems.com)
  • This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. (creativebiomart.net)
  • It contains Human CD30 / TNFRSF8 capture antibody, Human CD30 / TNFRSF8 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CD30 / TNFRSF8 protein. (sinobiological.com)
  • 2 A crystal structure of an extracellular fragment of human CD40 ligand. (ebi.ac.uk)
  • On and in our body's cells, CD40 Antigen is a surface glycoprotein expressed on all mature B lymphocytes, and a member of the tumor necrosis factor receptor superfamily with specificity for CD40 ligand , that plays an important role in B-cell development, growth, and differentiation. (wellnessadvocate.com)
  • Goldie-Cregan, LC, Croager, EJ & Abraham, L 2002, ' Characterization of the murine CD30 ligand (CD153) gene: Gene structure and expression ', Tissue Antigens , vol. 60, pp. 139-146. (edu.au)
  • A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (harvard.edu)
  • The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily. (peprotech.com)
  • Binds to human CD30 (Ki-1). (creativebiomart.net)
  • The ligand binds cell surface receptors and triggers internalization. (aacrjournals.org)
  • 2002) Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. (sinobiological.com)
  • The ED 50 for this effect is 1-5 μg/mL in the presence of 50 ng/mL of Recombinant Human CD30 Ligand (Catalog # 1028-CL). (rndsystems.com)
  • We identified TRAF protein aggregation in the cytoplasm of H-RS cells and also showed the involvement of TRAF protein aggregation in the signaling process of CD30. (nii.ac.jp)
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (creativebiomart.net)
  • Clone REA1083 recognizes the mouse CD153 (CD30 ligand) antigen, a 40 kDa type II membrane protein belonging to the NGF/TNF superfamily. (miltenyibiotec.com)
  • Murine CD30 cDNA predicts a protein of 498 amino acids with homology to the TNF receptor family of proteins characterized by repeated cysteine-rich motifs in the extracellular domain. (elsevier.com)
  • Murine CD30 cDNA was shown to be functional through the production of a soluble murine Ig fusion protein (CD30-Ig) that was active in binding to cells that expressed CD30 ligand. (elsevier.com)
  • Transient expression and quantitative binding studies show TRAIL-R3 to be a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. (rupress.org)
  • Elevated circulating soluble CD30 (sCD30) has been previously associated with AIDS-related non-Hodgkin lymphoma (NHL) risk. (aacrjournals.org)
  • Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. (nordicbiosite.com)
  • To assess whether persistent or recurrent elevated serial circulating markers of inflammation (including soluble CD30 [sCD30], soluble CD163 [sCD163], IL10, CCL17, or CCL22) correlate with relapse/progression or PET scan results. (clinicaltrials.gov)
  • Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. (harvard.edu)
  • Measured by its ability to block CD30 Ligand-induced IL-6 secretion by HDLM human Hodgkin's lymphoma cells. (rndsystems.com)
  • CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. (bioportfolio.com)
  • Sequence homology to members of the tumor necrosis factor (TNF) receptor super family can be observed in CD30, which is a surface marker for neoplastic cells of Hodgkin's lymphoma. (readabstracts.com)
  • The recombinant human ligand promotes the growth of CD3-stimulated T cells, but causes varied reactions, such as cell death, in many CD30+ lymphoma-derived clones. (readabstracts.com)
  • Analyses of molecular bases of Hodgkin lymphoma by CD30-NF-kB pathway. (nii.ac.jp)
  • Overexpression of CD30 and constitutive NF-κB activation characterizes tumor cells of Hodgkin's lymphoma (HL), Hodgkin and Reed-Sternberg (H-RS) cells. (nii.ac.jp)
  • The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kB activation in anaplastic large cell lymphoma. (nii.ac.jp)
  • Publications] Horie R, Watanabe M, Ishida T, Koiwa T, Aizawa S, Itoh K, Higashihara M, Kadin ME, Watanahe T: 'The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-κB activation in anaplastic large cell lymphoma. (nii.ac.jp)
  • CD30 is associated with anaplastic large cell lymphoma . (wikipedia.org)
  • [6] CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma . (wikipedia.org)
  • Soluble CD30: a possible serum tumor marker for primary effusion lymphoma," Asian Pacific Journal of Cancer Prevention , vol. 13, no. 10, pp. 4939-4941, 2012. (hindawi.com)
  • CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme," The Journal of Immunology , vol. 165, no. 12, pp. 6703-6709, 2000. (hindawi.com)
  • In this study, we evaluated the therapeutic efficacy of an anti-CD30 antibody, HeFi-1, armed with 211 At in a leukemia (karpas299) model and with 90 Y in a lymphoma (SUDHL-1) model. (pnas.org)
  • Increased expression of CD30 is observed on some neoplasms including Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL), mediastinal B cell lymphoma, embryonal carcinoma, seminoma, and mesothelioma ( 2 - 7 ). (pnas.org)
  • Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. (exbio.cz)
  • Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients. (bioportfolio.com)
  • We structurally and functionally characterized the CD30 promoter, and identified JunB as a molecule that is involved in CD30 overexpression in H-RS cells. (nii.ac.jp)
  • CD30 acts as a costimulatory molecule in thymic negative selection. (nordicbiosite.com)
  • and KPL-045, a monoclonal antibody inhibitor of the CD30 ligand co-stimulatory molecule. (marketbeat.com)
  • ligand polypeptide having a CD154 Domain III and a TNF.alpha. (patentgenius.com)
  • Furthermore, UO126 potentiated the activity of apoliprotein 2/tumor necrosis factor-related apoptosis-inducing ligand (APO2L/TRAIL) and chemotherapy-induced cell death. (bloodjournal.org)
  • 6 , 7 , 11 Furthermore, this activated pathway has been implicated in cancer cell resistance to chemotherapy and tumor necrosis factor-apoptosis inducing ligand (TRAIL/APO2L). (bloodjournal.org)
  • The former have a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNF.alpha. (patentgenius.com)
  • Tumor necrosis factor-related apoptosis inducing ligand (TRAIL, also called Apo2L or TNFSF10) is capable of inducing apoptosis in cancer cells but not in normal cells [ 29 ]. (biomedcentral.com)
  • Full length Clone DNA of Rhesus tumor necrosis factor (ligand) superfamily, member 8 with N terminal Myc tag. (sinobiological.com)
  • Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. (springer.com)
  • These observations identify OX40 and CD30 signals as essential for the development of clinically relevant CD4-dependent autoimmunity and suggest that combination therapies that abrogate these signals might be used to treat established human autoimmune diseases. (rupress.org)
  • To investigate the impact of abrogation of OX40 and CD30 signals on the development of autoimmunity in FoxP3 KO mice, male C57BL/6 mice, deficient in both OX40 and CD30 (double [d] KO), were crossed with females with a heterozygous null allele for the X-linked gene FoxP3 (FoxP3 het ). (rupress.org)
  • CD30 ligand is a new therapeutic target for central nervous system autoimmunity. (naver.com)
  • A sandwich ELISA for quantitative measurement of Porcine CD30 Ligand in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (antibody-antibodies.com)
  • CD30 ligation by CD30 Ligand mediates pleiotropic effects, including cell proliferation, activation, differentiation and apoptosis. (rndsystems.com)
  • 1 , 2 Under physiologic conditions, activation of the MAPK cascades by surface receptor/ligand interaction is tightly controlled and is involved in regulating cell proliferation, differentiation, and apoptosis. (bloodjournal.org)
  • We investigated apoptosis in distinct mucosal compartments, and the expression of Fas/Fas ligand and perforin in the inflamed and non- inflamed intestinal. (ebscohost.com)
  • In rheumatoid arthritis soluble CD30 ligand is present at high levels and induces apoptosis of CD30 + T cells," Immunology Letters , vol. 161, no. 2, pp. 236-240, 2014. (hindawi.com)
  • CD30 is a member of the TNF receptor superfamily, which includes TNF-R1, TNF-R2, Fas-R, CD40, CD27, and TNF-related apoptosis-inducing ligand receptor ( 1 ). (pnas.org)
  • Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. (neuromics.com)
  • Anti-CD30 monoclonal antibodies have been investigated for the treatment of CD30-expressing malignancies in vitro and in vivo ( 10 , 12 - 18 ). (pnas.org)
  • Several studies have shown that anti-CD30 monoclonal antibodies possessing signaling properties could inhibit the growth of ALCL cells, but very few of them were effective for HD cells ( 10 , 12 , 13 , 18 ). (pnas.org)
  • Furthermore, although preclinical studies showed that treatment with anti-CD30 monoclonal antibodies prolonged the survival of ALCL-bearing mice significantly, compared with the mice in the control group, many of the mice in the treatment group still died of the disease ( 15 , 16 ). (pnas.org)
  • Immunotoxins consist of cell-selective ligands (usually monoclonal antibodies, antibody fragments, or cytokines) linked covalently to modified peptide toxins. (aacrjournals.org)
  • Publications] Horie R, Higashihara M, Watanabe T.: 'The biology of Hodgkin's lymphpoma and CD30 signal transduction. (nii.ac.jp)
  • CD30 and TRAF proteins co-localized in H-RS cell lines and in lymph nodes of HL. (nii.ac.jp)
  • Thus, cytoplasmic aggregation of TRAF proteins appears to reflect constitutive CD30 signaling which is characteristic to H-RS cells. (nii.ac.jp)
  • Our results showed that F3 may induce death receptor ligands to initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. (biomedcentral.com)
  • These proteins elicit potent effector functions by binding target ligands (e.g. (doabooks.org)
  • In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3, and CCL5 (5, 12). (rndsystems.com)
  • In the present study, using immunohistochemistry, we studied the expression of CD30 and CD30-L in 35 deciduas obtained from women following elective abortion during normal physiological gestation and in 60 deciduas obtained from women after spontaneous abortion with or without signs of inflammation. (ejh.it)
  • The reduced expression of CD30 and CD30-L and their cellular pattern detected in the deciduas from spontaneous abortions suggest that the CD30/CD30-L system is crucial for preventing abortions in the first trimester. (ejh.it)
  • And furthermore, the distinctive expression of CD30/CD30- L in deciduas from physiological pregnancies may indicate that the CD30/CD30-L system exerts its main role in the first trimester. (ejh.it)
  • The cDNA cognate from the murine T cell clone 7B9 was expression cloned by using a chimeric probe with the extracellular region of CD30 linked to branched immunoglobulin heavy chains. (readabstracts.com)
  • As expected, ∼50% of male offspring heterozygous for expression of OX40 and CD30 (dKO het ) were FoxP3 deficient and developed lethal autoimmune disease at ∼4 wk ( Fig. 1 A ), characterized by weight loss ( Fig. 1 B ) and scurfy phenotype ( Fig. 1 C ). Because OX40 and CD30 are linked genetically, offspring have a high probability of inheriting deficiency in both genes as a haplotype. (rupress.org)
  • Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in systemic lupus erythematosus patients," Journal of Biomedicine and Biotechnology , vol. 2010, Article ID 569053, 8 pages, 2010. (hindawi.com)
  • Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration," Clinical and Experimental Immunology , vol. 117, no. 2, pp. 291-297, 1999. (hindawi.com)
  • Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a promising target for antibody-based therapy. (pnas.org)
  • In contrast, CD30 expression in normal tissues is limited to activated T cells, activated B cells, select thymocytes, and some vascular beds ( 2 ). (pnas.org)
  • Both HD and ALCL are characterized by the strong expression of CD30 on the malignant cell surfaces. (pnas.org)
  • In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. (nordicbiosite.com)
  • In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. (nordicbiosite.com)
  • These include difficulties in immunotoxin production, rarity of high affinity, tumor selective ligands, heterogeneity of antigen/receptor expression on tumor cell surfaces, nontargeted toxicities, and immunogenicity. (aacrjournals.org)
  • In anti-CD3-activated spleen cells, CD30 ligand is expressed primarily by CD4 + T cells, with peak expression at days 1 and 2, whereas CD30 is expressed primarily by CD8 + T cells, with peak expression on days 4 and 5. (elsevier.com)
  • 2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. (sinobiological.com)
  • CD30 is a member of the TNF receptor superfamily. (pnas.org)
  • CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. (nordicbiosite.com)
  • CD30-Ig also served as an immunogen for the production of hamster anti-mouse CD30 mAbs, which recognized both CD30 expressed by murine lymphocytes and CD30 expressed by cells transfected with murine CD30 cDNA. (elsevier.com)
  • Aizawa S, Satoh H, Horie R, Ito K, Choi SH, Takeuchi H, Watanabe T (1996) Cloning and characterization of a cDNA for rat CD30 homolog and chromosomal assignment of the genomic gene. (springer.com)
  • Mature human CD30 consists of a 361 amino acid (aa) extracellular domain (ECD) with six cysteine-rich repeats, a 28 aa transmembrane segment, and a 188 aa cytoplasmic domain (3). (rndsystems.com)
  • Alternate splicing of human CD30 generates an isoform that includes only the C‑terminal 132 aa of the cytoplasmic domain. (rndsystems.com)
  • Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling (15). (rndsystems.com)
  • Dr. Eid said CheckMate 436 ( NCT02581631 ) was designed to "take advantage" of these characteristics by employing the anti-PD-1 checkpoint inhibitor nivolumab and the anti-CD30 antibody-drug conjugate brentuximab vedotin. (mdedge.com)
  • 1. A method for treating an inflammatory or an autoimmune condition, which comprises administering a therapeutically effective amount of an IL-1 inhibitor and an OX40 ligand inhibitor. (patentsencyclopedia.com)
  • 9. The method of any one of claims 1 to 7, wherein the OX40 ligand inhibitor is an anti-OX40 ligand antibody. (patentsencyclopedia.com)
  • CD30-mediated signal transduction is capable of promoting cell proliferation and cell survival as well as antiproliferative effects and cell death depending on cell type and costimulatory effects ( 19 ). (pnas.org)
  • Identification of high-affinity, adequately tumor-selective ligands has been challenging, particularly for epithelial cancers. (aacrjournals.org)
  • This result was supported by the observation that blocking antibodies to OX40 and CD30 ligands also abrogated disease mediated by FoxP3-deficient T cells. (rupress.org)
  • Our previous studies have implicated signaling through the tumor necrosis family receptors OX40 and CD30 as critical for maintaining CD4 memory responses. (rupress.org)
  • However, in the combined absence of OX40 and CD30, FoxP3-deficient mice develop normally and breed successfully. (rupress.org)
  • We show in this paper that FoxP3 T reg cells are dispensable in mice deficient in OX40 and CD30 signals. (rupress.org)
  • FoxP3-deficient mice lacking OX40 and CD30 develop and grow normally, fail to develop clinically relevant autoimmune disease, and have a normal lifespan. (rupress.org)
  • We also show that blocking mAbs to OX40 and CD30 ligands abrogates development of FoxP3 KO disease. (rupress.org)
  • OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function. (birmingham.ac.uk)
  • Circulating levels of soluble CD30, a marker of cells producing Th2-type cytokines, are increased in patients with systemic lupus erythematosus and correlate with disease activity," Clinical and Experimental Rheumatology , vol. 13, no. 3, pp. 339-343, 1995. (hindawi.com)
  • Murine CD30, although homologous to human CD30, has a 90 amino acid gap in an extracellular region that appears to be duplicated in human CD30. (elsevier.com)
  • Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. (ebi.ac.uk)
  • The interaction between CD30 and CD153 enhance the proliferation of stimulated T cells but in the presence of the REA1083 antibody this effect is blocked. (miltenyibiotec.com)
  • The interaction between CD30 and CD153 enhance the proliferation of stimulated T cells. (miltenyibiotec.com)
  • CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. (sinobiological.com)
  • 2004) CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. (sinobiological.com)
  • In summary, radiolabeled HeFi-1 is very promising for the treatment of CD30-expressing leukemias and lymphomas, and the combination regimen of 211 At-HeFi-1 with unmodified HeFi-1 enhanced the therapeutic efficacy. (pnas.org)
  • CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. (nordicbiosite.com)
  • 1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. (miltenyibiotec.com)
  • Flow cytometry analysis (surface staining) of K562 cells added to human blood, with anti-CD30 (MEM-268) PE. (exbio.cz)
  • Stimulation of CD30 by plate-bound anti-CD30 directly signaled for IL-5 but not IFN-γ production by CD30 + CTL lines. (elsevier.com)
  • Activation of CD30, CD40, and receptor activator of nuclear kappaβ (RANK) receptors in HD cells by their respective ligands increased ERK phosphorylation above the basal level and promoted HD cell survival. (bloodjournal.org)
  • Thymus colonisation and thymocyte positioning are regulated by interactions between CCR7 and CCR9, and their respective ligands, CCL19/CCL21 and CCL25. (diva-portal.org)
  • CD30 signaling co‑stimulates antigen-induced Th0 and Th2 proliferation and cytokine secretion but favors a Th2-biased immune response (8). (rndsystems.com)
  • Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (1999) Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. (springer.com)
  • CD30 is the target of the FDA approved therapeutic brentuximab vedotin (Adcetris). (wikipedia.org)
  • Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases. (sinobiological.com)
  • Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. (doabooks.org)
  • This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands. (doabooks.org)
  • CD30 contributes to thymic negative selection by inducing the apoptotic cell death of CD4+CD8+ T cells (10, 11). (rndsystems.com)
  • Fischer M, Harvima IT, Carvalho RF, Möller C, Naukkarinen A, Enblad G, Nilsson G: Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. (exbio.cz)
  • These studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 signaling may be pivotal in the pattern of cytokine production by T cells. (elsevier.com)
  • We report that in H-RS cells overexpression of CD30 leads to self-aggregation, recruitment of TRAF2 and TRAF5, and NF-κB activation, independent of CD30 ligand. (nii.ac.jp)
  • Prior research has shown that PMBCL is often characterized by overexpression of the PD-1 ligands PD-L1 and PD-L2, and most PMBCL expresses CD30. (mdedge.com)
  • Type A is characterized by a a wedge-shaped diffuse dermal infiltrate containing scattered or clustered medium-sized to large pleomorphic or anaplastic lymphoid cells that are positive for CD30 (Figure 4). (renalandurologynews.com)
  • Within common regions of the ECD, human CD30 shares 53% and 49% aa sequence identity with mouse and rat CD30, respectively. (rndsystems.com)
  • This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human TNFSF4, also called OX40 ligand. (novusbio.com)
  • Immobilized Human CD30 Ligand, Mouse IgG2a Fc Tag, at 5 μg/mL (100 μL/well) can bind ab220597 with a linear range of 8-125 ng/mL. (abcam.com)
  • Optimized DNA sequence encoding Human CD30 Ligand including an N-terminal IgG1 Fc tag was expressed in HEK293 cells. (reprokine.com)
  • CD30 plays a critical role in Th17 differentiation in mice. (nii.ac.jp)
  • AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells'Am J Pathol. (nii.ac.jp)
  • Ligand independent signaling by overexpressed CD30 drives NF-kB activation in Hodgkin and Reed-Sternberg cells. (nii.ac.jp)
  • Publications] Watanabe M, Ogawa Y, Ito K, Higashihara M, Kadin ME, Watanabe T, Horie R: 'AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells'Am J Pathol. (nii.ac.jp)
  • CD153 (CD30 ligand) has been described as a 40-kDa type II transmembrane glycoprotein belonging to the TNF superfamily and is expressed primarily by activated T cells, B cells and monocytes. (edu.au)
  • In addition to acting as the decoy receptor for Fas ligand (FasL) ( 13 ), DcR3 competes with HSV glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes (LIGHT) ( 14 ), and with TL1A ( 15 ). (jimmunol.org)
  • An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage (13, 14). (rndsystems.com)
  • UO126 inhibited basal and ligand-induced ERK phosphorylation, and inhibited ligand-induced cell survival of HD cell lines. (bloodjournal.org)
  • Increased bone marrow (BM) plasma level of soluble CD30 and correlations with BM plasma level of interferon (IFN)- γ , CD4/CD8 T-cell ratio and disease aeverity in aplastic anemia," PLoS ONE , vol. 9, no. 11, Article ID e110787, 2014. (hindawi.com)
  • CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. (nordicbiosite.com)
  • Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Akt Signaling . (genecards.org)
  • The ligands of CCR7 and CCR9 also interact with the atypical receptor CCRL1 (also known as ACKR4), which is expressed in the thymus and has recently been reported to play an important role in normal alpha beta T-cell development. (diva-portal.org)