A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Adherence of cells to surfaces or to other cells.
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
The series of changes to the shape, size, components, and functions of an individual organism that occur over time as the organism progresses from its initial form to full size and maturity.
Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
A subfamily in the family MURIDAE, comprising the Old World MICE and RATS.
Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Polymorphic cells that form cartilage.

Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (1/98)

We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from primary human osteoblast cells encoding a 250-amino acid single chain polypeptide. Murine CTGF-L cDNA, encoding a polypeptide of 251 amino acids, was obtained from a murine lung cDNA library. CTGF-L protein bears significant identity ( approximately 60%) to the CCN (CTGF, Cef10/Cyr61, Nov) family of proteins. CTGF-L is composed of three distinct domains, an insulin-like growth factor binding domain, a von Willebrand Factor type C motif, and a thrombospondin type I repeat. However, unlike CTGF, CTGF-L lacks the C-terminal domain implicated in dimerization and heparin binding. CTGF-L mRNA ( approximately 1.3 kilobases) is expressed in primary human osteoblasts, fibroblasts, ovary, testes, and heart, and a approximately 26-kDa protein is secreted from primary human osteoblasts and fibroblasts. In situ hybridization indicates high expression in osteoblasts forming bone, discrete alkaline phosphatase positive bone marrow cells, and chondrocytes. Specific binding of 125I-labeled insulin-like growth factors to CTGF-L was demonstrated by ligand Western blotting and cross-linking experiments. Recombinant human CTGF-L promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, recombinant human CTGF-L inhibits osteocalcin production in rat osteoblast-like Ros 17/2.8 cells. Taken together, these results suggest that CTGF-L may play an important role in modulating bone turnover.  (+info)

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. (2/98)

Inflammatory breast cancer is a rapidly growing, distinct form of locally advanced breast cancer that carries a guarded prognosis. To identify the genes that contribute to this aggressive phenotype, we compared under- and overexpressed sequences in an inflammatory breast tumor cell line with those of actively replicating normal human mammary epithelial cell lines using differential display. Of the 17 transcripts isolated and characterized from these experiments, overexpression of RhoC GTPase and loss of expression of a novel gene on 6q22, LIBC (lost in inflammatory breast cancer), were highly correlated (P<0.0095 and P<0.0013, respectively) with the inflammatory phenotype when a panel of archival inflammatory breast cancers was compared with noninflammatory stage III breast cancers by in situ hybridization. This study suggests two new molecular markers specific for inflammatory breast cancer.  (+info)

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. (3/98)

WISP-1 (Wnt-1 induced secreted protein 1) is a member of the CCN family of growth factors. This study identifies WISP-1 as a beta-catenin-regulated gene that can contribute to tumorigenesis. The promoter of WISP-1 was cloned and shown to be activated by both Wnt-1 and beta-catenin expression. TCF/LEF sites played a minor role, whereas the CREB site played an important role in this transcriptional activation. WISP-1 demonstrated oncogenic activities; overexpression of WISP-1 in normal rat kidney fibroblast cells (NRK-49F) induced morphological transformation, accelerated cell growth, and enhanced saturation density. Although these cells did not acquire anchorage-independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1.  (+info)

N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (4/98)

Hereditary motor and sensory neuropathies, to which Charcot-Marie-Tooth (CMT) disease belongs, are a common cause of disability in adulthood. Growing awareness that axonal loss, rather than demyelination per se, is responsible for the neurological deficit in demyelinating CMT disease has focused research on the mechanisms of early development, cell differentiation, and cell-cell interactions in the peripheral nervous system. Autosomal recessive peripheral neuropathies are relatively rare but are clinically more severe than autosomal dominant forms of CMT, and understanding their molecular basis may provide a new perspective on these mechanisms. Here we report the identification of the gene responsible for hereditary motor and sensory neuropathy-Lom (HMSNL). HMSNL shows features of Schwann-cell dysfunction and a concomitant early axonal involvement, suggesting that impaired axon-glia interactions play a major role in its pathogenesis. The gene was previously mapped to 8q24.3, where conserved disease haplotypes suggested genetic homogeneity and a single founder mutation. We have reduced the HMSNL interval to 200 kb and have characterized it by means of large-scale genomic sequencing. Sequence analysis of two genes located in the critical region identified the founder HMSNL mutation: a premature-termination codon at position 148 of the N-myc downstream-regulated gene 1 (NDRG1). NDRG1 is ubiquitously expressed and has been proposed to play a role in growth arrest and cell differentiation, possibly as a signaling protein shuttling between the cytoplasm and the nucleus. We have studied expression in peripheral nerve and have detected particularly high levels in the Schwann cell. Taken together, these findings point to NDRG1 having a role in the peripheral nervous system, possibly in the Schwann-cell signaling necessary for axonal survival.  (+info)

A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (5/98)

Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, nephroblastoma overexpressed) encode cysteine-rich secreted proteins with roles in human fibrotic disorders and cancer progression. Using targeted differential displays, we identified a novel variant of the CCN family member WISP1 (Wnt-induced secreted protein 1), named WISP1v, as overexpressed in scirrhous gastric carcinomas. Predicted protein of the WISP1v completely lacks a module of Von Willebrand type C that is thought to participate in protein complex formation. Ectopic expression revealed WISP1v to be a secreted oncoprotein inducing a striking cellular transformation and rapid piling-up growth. It is noteworthy that WISP1v transfectants enhanced the invasive phenotype of co-cultured gastric carcinoma cells, while wild-type WISP1 had no such potential. These findings suggest that CCN protein WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma.  (+info)

WISP-1 binds to decorin and biglycan. (6/98)

Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Structural and experimental evidence suggests that CCN family member activities are modulated by their interaction with sulfated glycoconjugates. To elucidate the mechanism of action for WISP-1, we characterized the specificity of its tissue and cellular interaction and identified binding factors. WISP-1 binding was restricted to the stroma of colon tumors and to cells with a fibroblastic phenotype. By using a solid phase assay, we showed that human skin fibroblast conditioned media contained WISP-1 binding factors. Competitive inhibition with different glycosaminoglycans and treatment with glycosaminoglycan lyases and proteases demonstrated that binding to the conditioned media was mediated by dermatan sulfate proteoglycans. Mass spectrometric analysis identified the isolated binding factors as decorin and biglycan. Decorin and biglycan interacted directly with WISP-1 and inhibited its binding to components in the conditioned media. Similarly, WISP-1 interaction with human skin fibroblasts was inhibited by dermatan sulfate, decorin, and biglycan or by treatment of the cell surface with dermatan sulfate-specific lyases. Together these results demonstrate that decorin and biglycan are WISP-1 binding factors that can mediate and modulate its interaction with the surface of fibroblasts. We propose that this specific interaction plays a role in the regulation of WISP-1 function.  (+info)

COL11A1 in FAP polyps and in sporadic colorectal tumors. (7/98)

BACKGROUND: We previously reported that the alpha-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin. METHODS: We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/beta-catenin pathway. RESULTS: In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/beta-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas. CONCLUSIONS: Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/beta-catenin pathway in FAP and sporadic colorectal cancer.  (+info)

Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. (8/98)

To gain insight into the role of the CCN genes in human breast carcinomas, we quantified connective tissue growth factor (CTGF), WISP-1, CYR61, and human NOV (NOVH) mRNA expression levels in samples from 44 primary breast tumors and seven normal breasts using quantitative real-time PCR assay. Overexpression of CTGF, WISP-1, CYR61, and NOVH was found in 55 (24 of 44), 46 (20 of 44), 39 (17 of 44), and 11% (5 of 44) primary breast tumors, respectively. Statistical univariate analysis was performed to explore the links between expression of the CCN genes and clinical and pathological parameters. Interestingly, significant associations were found between CTGF expression versus stage, tumor size, lymph node status, and age at diagnosis; WISP-1 mRNA levels versus stage, tumor size, lymph node, and HER-2/neu overexpression; and CYR61 expression with stage, tumor size, lymph node, age, and estrogen receptor expression. In contrast to CTGF, WISP-1, and CYR61, no significant correlation was found between NOVH expression and any of the clinical and pathological factors. Furthermore, multivariate classification tree model analysis showed that stage and lymph node involvement were important for predicting CTGF expression in breast cancers; the stage, age, and HER-2/neu status were key factors for WISP-1 expression; and the stage, age, and estrogen receptor were valuable predictors for CYR61 expression. In summary, these results suggest that CTGF, WISP-1, and CYR61 may play a role in the progression of breast cancer and might serve as a valuable tool for monitoring tumor status of breast cancer patients.  (+info)

Gingival fibromatosis is relatively rare and usually does not require treatment unless it becomes inflamed or infected. Treatment options may include antibiotics, surgical removal of the growth, or other methods to reduce inflammation and improve oral hygiene.

Synonyms:

* Gingival fibroma
* Pyogenic granuloma
* Peripheral giant cell granuloma
* Fibromatous hyperplasia of the gingiva

Note: The term "fibromatosis" refers to the excessive growth of fibrous tissue, which can occur in various parts of the body. In the context of oral health, it specifically refers to the growth of fibrous tissue on the gums.

Fibrosis can occur in response to a variety of stimuli, including inflammation, infection, injury, or chronic stress. It is a natural healing process that helps to restore tissue function and structure after damage or trauma. However, excessive fibrosis can lead to the loss of tissue function and organ dysfunction.

There are many different types of fibrosis, including:

* Cardiac fibrosis: the accumulation of scar tissue in the heart muscle or walls, leading to decreased heart function and potentially life-threatening complications.
* Pulmonary fibrosis: the accumulation of scar tissue in the lungs, leading to decreased lung function and difficulty breathing.
* Hepatic fibrosis: the accumulation of scar tissue in the liver, leading to decreased liver function and potentially life-threatening complications.
* Neurofibromatosis: a genetic disorder characterized by the growth of benign tumors (neurofibromas) made up of fibrous connective tissue.
* Desmoid tumors: rare, slow-growing tumors that are made up of fibrous connective tissue and can occur in various parts of the body.

Fibrosis can be diagnosed through a variety of methods, including:

* Biopsy: the removal of a small sample of tissue for examination under a microscope.
* Imaging tests: such as X-rays, CT scans, or MRI scans to visualize the accumulation of scar tissue.
* Blood tests: to assess liver function or detect specific proteins or enzymes that are elevated in response to fibrosis.

There is currently no cure for fibrosis, but various treatments can help manage the symptoms and slow the progression of the condition. These may include:

* Medications: such as corticosteroids, immunosuppressants, or chemotherapy to reduce inflammation and slow down the growth of scar tissue.
* Lifestyle modifications: such as quitting smoking, exercising regularly, and maintaining a healthy diet to improve overall health and reduce the progression of fibrosis.
* Surgery: in some cases, surgical removal of the affected tissue or organ may be necessary.

It is important to note that fibrosis can progress over time, leading to further scarring and potentially life-threatening complications. Regular monitoring and follow-up with a healthcare professional are crucial to managing the condition and detecting any changes or progression early on.

CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their ... CCN proteins likely constitute a hub for the coordination of cell signaling and communication. The CCN protein family includes ... Intercellular+Signaling+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) (CCN proteins). ... WNT1 inducible signaling pathway protein-2) CCN6: WISP3 (WNT1 inducible signaling pathway protein-3) Jun JI, Lau LF (December ...
... associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad ... Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines". J. Cell Commun. Signal ...
CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. The ... comprise the six-member CCN family in vertebrates. CCN proteins characteristically contain an N-terminal secretory signal ... WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the ... The CCN family of proteins regulates diverse cellular functions, including cell adhesion, migration, proliferation, survival, ...
... associated signaling proteins (see also CCN intercellular signaling protein). The CCN acronym is derived from the first three ... These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six-member CCN family in vertebrates ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Chen CC, Lau LF (Apr 2009). "Functions and mechanisms of action of CCN matricellular proteins". The International Journal of ...
CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. The ... comprise the six-member CCN family in vertebrates. CCN proteins characteristically contain an N-terminal secretory signal ... WNT1-inducible-signaling pathway protein 2, or WISP-2 (also named CCN5) is a matricellular protein that in humans is encoded by ... The CCN family of proteins regulates diverse cellular functions, including cell adhesion, migration, proliferation, ...
Examples of matricellular proteins include the CCN family of proteins (also known as CCN intercellular signaling protein), ... Many of these proteins have important functions in wound healing and tissue repair. CCN protein Bornstein P (August 1995). " ... v t e (Matricellular proteins, Extracellular matrix proteins, All stub articles, Protein stubs). ... Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nat Rev ...
... associated signaling proteins (CCN intercellular signaling protein). The CCN family of proteins shares a common molecular ... WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded ... WISP1 WNT1 inducible signaling pathway protein 1". Chen CC, Lau LF (Apr 2009). "Functions and mechanisms of action of CCN ... Jun JI, Lau LF (Dec 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nature ...
... the first three proteins identified that belong to the "CCN" protein family - also see CCN intercellular signaling protein ... CCN may refer to: Cement chemist notation, developed to simplify the formulas used by cement chemists Cereal cyst nematode, a ... see Nutrition This disambiguation page lists articles associated with the title CCN. If an internal link led you here, you may ...
... see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, ... is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins ( ... Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich ... Chen CC, Lau LF (April 2009). "Functions and mechanisms of action of CCN matricellular proteins". Int. J. Biochem. Cell Biol. ...
CCN Intercellular Signaling Proteins Entry term(s). CCN Family Proteins CYR61 CTGF NOV Matricellular Proteins Matricellular CCN ... CCN Intercellular Signaling Proteins - Preferred Concept UI. M0518136. Scope note. A family of secreted proteins found ... CCN Family Proteins. CYR61 CTGF NOV Matricellular Proteins. Matricellular CCN Proteins. Tree number(s):. D12.644.276.200. ... The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
CCN Intercellular Signaling Proteins [D12.644.276.200] * Cytokines [D12.644.276.374] * EGF Family of Proteins [D12.644.276.382] ... Intercellular Signaling Peptides and Proteins [D12.644.276] * Adipokines [D12.644.276.024] * Agouti Signaling Protein [D12.644. ... Intercellular Signaling Peptides and Proteins [D12.776.467] * Adipokines [D12.776.467.024] * Agouti Signaling Protein [D12.776. ... Amino Acids, Peptides, and Proteins [D12] * Proteins [D12.776] * ... Agouti Signaling Protein [D23.529.049] * Agouti-Related Protein ...
Agouti Signaling Protein. *Agouti-Related Protein. *Angiogenic Proteins. *B7 Antigens. *CCN Intercellular Signaling Proteins ... "Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... This graph shows the total number of publications written about "Parathyroid Hormone-Related Protein" by people in this website ... A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to ...
Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family, regulates cell proliferation, ... TGF-beta signal transduction: biology, function and therapy for diseases. Tie, Yan; Tang, Fan; Peng, Dandan; Zhang, Ye; Shi, ... Exosomes are essential carriers of intercellular communication. Most previous studies have focused on adipocyte- and hepatocyte ... which destroys the contextual relevance of signal data. Therefore, studying the multi-label classification of ECG signals ...
CCN Intercellular Signaling Proteins [D12.776.860.300.200] CCN Intercellular Signaling Proteins * Collagen [D12.776.860.300.250 ... LETS Proteins Opsonic Glycoprotein Opsonic alpha(2)SB Glycoprotein Proteins, LETS alpha 2 Surface Binding Glycoprotein alpha 2- ... LETS Proteins. Opsonic Glycoprotein. Opsonic alpha(2)SB Glycoprotein. Proteins, LETS. alpha 2 Surface Binding Glycoprotein. ... extracellular matrix proteins; /biosyn /physiol permitted. Allowable Qualifiers:. AD administration & dosage. AE adverse ...
A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT4 receptor ... Expression profiles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis. Masatoshi Komatsu, Yukio ... Regulation of Chondrocyte Differentiation by Changing Intercellular Distances Using Type II Collagen Microfibers. Jinyu Li, ... In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein ...
intercellular the online Volkswirtschaftslehre of another design, which is only more atmospheric restless systems. I submitted ... A usually obtainable online to drive the speed of Rayleigh wall on cellulose proteins, as its motion approach is ... In polyfunctional Answers of the m. vehicle data, the benefits outside quantities are various sigma access sources( CCN) that ... to what would potentially extend crucial times massive typically through the mean sonar of a sampling of used small-signal ...
... and components of the Wnt signaling pathway have been linked to tumorigenesis in familial and sporadic colon carcinomas. Here ... CCN Intercellular Signaling Proteins Actions. * Search in PubMed * Search in MeSH * Add to Search ... WNT1 Inducible Signaling Pathway Protein 1 Is a Stroma-Specific Secreting Protein Inducing a Fibroblast Contraction and ... Encoded amino acid sequence alignment of mouse and human WISP-1 (A) and mouse and human WISP-2 (B). The potential signal ...
Cartilage Oligomeric Matrix Protein [D12.776.860.300.155] * CCN Intercellular Signaling Proteins [D12.776.860.300.200] * ... Intercellular Signaling Peptides and Proteins [D12.644.276] * Adipokines [D12.644.276.024] * Agouti Signaling Protein [D12.644. ... Intercellular Signaling Peptides and Proteins [D12.776.467] * Adipokines [D12.776.467.024] * Agouti Signaling Protein [D12.776. ... and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.. Terms. CCN Intercellular Signaling Proteins Preferred Term Term UI T713987. Date02/ ...
Cartilage Oligomeric Matrix Protein [D12.776.860.300.155] * CCN Intercellular Signaling Proteins [D12.776.860.300.200] * ... Intercellular Signaling Peptides and Proteins [D12.644.276] * Adipokines [D12.644.276.024] * Agouti Signaling Protein [D12.644. ... Intercellular Signaling Peptides and Proteins [D12.776.467] * Adipokines [D12.776.467.024] * Agouti Signaling Protein [D12.776. ... and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.. Terms. CCN Intercellular Signaling Proteins Preferred Term Term UI T713987. Date02/ ...
Binding Protein-delta N0000169870 CCAAT-Enhancer-Binding Proteins N0000178844 CCN Intercellular Signaling Proteins N0000175237 ... Nod1 Signaling Adaptor Protein N0000175217 Nod2 Signaling Adaptor Protein N0000178841 Nodal Protein N0000178840 Nodal Signaling ... Protein Precursors N0000170932 Protein S N0000170621 Protein Sorting Signals N0000169154 Protein Subunits N0000178699 Protein ... N0000169241 HMGB3 Protein N0000169206 HMGN Proteins N0000169207 HMGN1 Protein N0000169208 HMGN2 Protein N0000171143 HN Protein ...
AN - coordinate with CROSS INFECTION if pertinent HN - 2009 FX - Cross Infection MH - CCN Intercellular Signaling Proteins UI ... The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and ... HN - 2009(1979) FX - Cornified Envelope Proline-Rich Proteins FX - Salivary Proline-Rich Proteins MH - Protein Multimerization ... PROTEIN. HN - 2009(1996) BX - Lefty Proteins MH - Light Signal Transduction UI - D055537 MN - G2.111.87.800.480 MN - G2.149. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Proteínas de Sinalização Intercelular CCN. CCN Intercellular Signaling Proteins. Proteínas CCN de Señalización Intercelular. ... Shc Signaling Adaptor Proteins. Proteínas Adaptadoras de la Señalización Shc. Proteínas Centrais de snRNP. snRNP Core Proteins ... Seed Storage Proteins. Proteínas de Almacenamiento de Semillas. Proteínas de Choque Térmico HSP27. HSP27 Heat-Shock Proteins. ...
Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral ... Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell ... 4. WISP-1 a novel angiogenic regulator of the CCN family promotes oral squamous cell carcinoma angiogenesis through VEGF-A ... 1. Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma ...
  • Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)

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