A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Adherence of cells to surfaces or to other cells.
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
The series of changes to the shape, size, components, and functions of an individual organism that occur over time as the organism progresses from its initial form to full size and maturity.
Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
A subfamily in the family MURIDAE, comprising the Old World MICE and RATS.
Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Polymorphic cells that form cartilage.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)
A parathyroid hormone receptor subtype that recognizes both PARATHYROID HORMONE and PARATHYROID HORMONE-RELATED PROTEIN. It is a G-protein-coupled receptor that is expressed at high levels in BONE and in KIDNEY.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Cell surface proteins that bind PARATHYROID HORMONE with high affinity and trigger intracellular changes which influence the behavior of cells. Parathyroid hormone receptors on BONE; KIDNEY; and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis.
MAMMARY GLANDS in the non-human MAMMALS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Measurement of distances or movements by means of the phenomena caused by the interference of two rays of light (optical interferometry) or of sound (acoustic interferometry).
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The rate dynamics in chemical or physical systems.
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It has been shown to mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It is found in a variety of adult tissues of BRAIN; HEART; and KIDNEY.
A transmembrane domain containing ephrin that is specific for EPHB1 RECEPTOR; EPHB2 RECEPTOR and EPHB3 RECEPTOR. It is widely expressed in a variety of developing and adult tissues.
An eph family receptor found widely expressed in embryonic and adult tissues. High levels of EphB2 receptor are observed in growing AXONS and NERVE FIBERS. Several isoforms of the protein exist due to multiple alternative mRNA splicing.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.

Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (1/98)

We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from primary human osteoblast cells encoding a 250-amino acid single chain polypeptide. Murine CTGF-L cDNA, encoding a polypeptide of 251 amino acids, was obtained from a murine lung cDNA library. CTGF-L protein bears significant identity ( approximately 60%) to the CCN (CTGF, Cef10/Cyr61, Nov) family of proteins. CTGF-L is composed of three distinct domains, an insulin-like growth factor binding domain, a von Willebrand Factor type C motif, and a thrombospondin type I repeat. However, unlike CTGF, CTGF-L lacks the C-terminal domain implicated in dimerization and heparin binding. CTGF-L mRNA ( approximately 1.3 kilobases) is expressed in primary human osteoblasts, fibroblasts, ovary, testes, and heart, and a approximately 26-kDa protein is secreted from primary human osteoblasts and fibroblasts. In situ hybridization indicates high expression in osteoblasts forming bone, discrete alkaline phosphatase positive bone marrow cells, and chondrocytes. Specific binding of 125I-labeled insulin-like growth factors to CTGF-L was demonstrated by ligand Western blotting and cross-linking experiments. Recombinant human CTGF-L promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, recombinant human CTGF-L inhibits osteocalcin production in rat osteoblast-like Ros 17/2.8 cells. Taken together, these results suggest that CTGF-L may play an important role in modulating bone turnover.  (+info)

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. (2/98)

Inflammatory breast cancer is a rapidly growing, distinct form of locally advanced breast cancer that carries a guarded prognosis. To identify the genes that contribute to this aggressive phenotype, we compared under- and overexpressed sequences in an inflammatory breast tumor cell line with those of actively replicating normal human mammary epithelial cell lines using differential display. Of the 17 transcripts isolated and characterized from these experiments, overexpression of RhoC GTPase and loss of expression of a novel gene on 6q22, LIBC (lost in inflammatory breast cancer), were highly correlated (P<0.0095 and P<0.0013, respectively) with the inflammatory phenotype when a panel of archival inflammatory breast cancers was compared with noninflammatory stage III breast cancers by in situ hybridization. This study suggests two new molecular markers specific for inflammatory breast cancer.  (+info)

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. (3/98)

WISP-1 (Wnt-1 induced secreted protein 1) is a member of the CCN family of growth factors. This study identifies WISP-1 as a beta-catenin-regulated gene that can contribute to tumorigenesis. The promoter of WISP-1 was cloned and shown to be activated by both Wnt-1 and beta-catenin expression. TCF/LEF sites played a minor role, whereas the CREB site played an important role in this transcriptional activation. WISP-1 demonstrated oncogenic activities; overexpression of WISP-1 in normal rat kidney fibroblast cells (NRK-49F) induced morphological transformation, accelerated cell growth, and enhanced saturation density. Although these cells did not acquire anchorage-independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1.  (+info)

N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (4/98)

Hereditary motor and sensory neuropathies, to which Charcot-Marie-Tooth (CMT) disease belongs, are a common cause of disability in adulthood. Growing awareness that axonal loss, rather than demyelination per se, is responsible for the neurological deficit in demyelinating CMT disease has focused research on the mechanisms of early development, cell differentiation, and cell-cell interactions in the peripheral nervous system. Autosomal recessive peripheral neuropathies are relatively rare but are clinically more severe than autosomal dominant forms of CMT, and understanding their molecular basis may provide a new perspective on these mechanisms. Here we report the identification of the gene responsible for hereditary motor and sensory neuropathy-Lom (HMSNL). HMSNL shows features of Schwann-cell dysfunction and a concomitant early axonal involvement, suggesting that impaired axon-glia interactions play a major role in its pathogenesis. The gene was previously mapped to 8q24.3, where conserved disease haplotypes suggested genetic homogeneity and a single founder mutation. We have reduced the HMSNL interval to 200 kb and have characterized it by means of large-scale genomic sequencing. Sequence analysis of two genes located in the critical region identified the founder HMSNL mutation: a premature-termination codon at position 148 of the N-myc downstream-regulated gene 1 (NDRG1). NDRG1 is ubiquitously expressed and has been proposed to play a role in growth arrest and cell differentiation, possibly as a signaling protein shuttling between the cytoplasm and the nucleus. We have studied expression in peripheral nerve and have detected particularly high levels in the Schwann cell. Taken together, these findings point to NDRG1 having a role in the peripheral nervous system, possibly in the Schwann-cell signaling necessary for axonal survival.  (+info)

A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (5/98)

Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, nephroblastoma overexpressed) encode cysteine-rich secreted proteins with roles in human fibrotic disorders and cancer progression. Using targeted differential displays, we identified a novel variant of the CCN family member WISP1 (Wnt-induced secreted protein 1), named WISP1v, as overexpressed in scirrhous gastric carcinomas. Predicted protein of the WISP1v completely lacks a module of Von Willebrand type C that is thought to participate in protein complex formation. Ectopic expression revealed WISP1v to be a secreted oncoprotein inducing a striking cellular transformation and rapid piling-up growth. It is noteworthy that WISP1v transfectants enhanced the invasive phenotype of co-cultured gastric carcinoma cells, while wild-type WISP1 had no such potential. These findings suggest that CCN protein WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma.  (+info)

WISP-1 binds to decorin and biglycan. (6/98)

Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Structural and experimental evidence suggests that CCN family member activities are modulated by their interaction with sulfated glycoconjugates. To elucidate the mechanism of action for WISP-1, we characterized the specificity of its tissue and cellular interaction and identified binding factors. WISP-1 binding was restricted to the stroma of colon tumors and to cells with a fibroblastic phenotype. By using a solid phase assay, we showed that human skin fibroblast conditioned media contained WISP-1 binding factors. Competitive inhibition with different glycosaminoglycans and treatment with glycosaminoglycan lyases and proteases demonstrated that binding to the conditioned media was mediated by dermatan sulfate proteoglycans. Mass spectrometric analysis identified the isolated binding factors as decorin and biglycan. Decorin and biglycan interacted directly with WISP-1 and inhibited its binding to components in the conditioned media. Similarly, WISP-1 interaction with human skin fibroblasts was inhibited by dermatan sulfate, decorin, and biglycan or by treatment of the cell surface with dermatan sulfate-specific lyases. Together these results demonstrate that decorin and biglycan are WISP-1 binding factors that can mediate and modulate its interaction with the surface of fibroblasts. We propose that this specific interaction plays a role in the regulation of WISP-1 function.  (+info)

COL11A1 in FAP polyps and in sporadic colorectal tumors. (7/98)

BACKGROUND: We previously reported that the alpha-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin. METHODS: We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/beta-catenin pathway. RESULTS: In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/beta-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas. CONCLUSIONS: Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/beta-catenin pathway in FAP and sporadic colorectal cancer.  (+info)

Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. (8/98)

To gain insight into the role of the CCN genes in human breast carcinomas, we quantified connective tissue growth factor (CTGF), WISP-1, CYR61, and human NOV (NOVH) mRNA expression levels in samples from 44 primary breast tumors and seven normal breasts using quantitative real-time PCR assay. Overexpression of CTGF, WISP-1, CYR61, and NOVH was found in 55 (24 of 44), 46 (20 of 44), 39 (17 of 44), and 11% (5 of 44) primary breast tumors, respectively. Statistical univariate analysis was performed to explore the links between expression of the CCN genes and clinical and pathological parameters. Interestingly, significant associations were found between CTGF expression versus stage, tumor size, lymph node status, and age at diagnosis; WISP-1 mRNA levels versus stage, tumor size, lymph node, and HER-2/neu overexpression; and CYR61 expression with stage, tumor size, lymph node, age, and estrogen receptor expression. In contrast to CTGF, WISP-1, and CYR61, no significant correlation was found between NOVH expression and any of the clinical and pathological factors. Furthermore, multivariate classification tree model analysis showed that stage and lymph node involvement were important for predicting CTGF expression in breast cancers; the stage, age, and HER-2/neu status were key factors for WISP-1 expression; and the stage, age, and estrogen receptor were valuable predictors for CYR61 expression. In summary, these results suggest that CTGF, WISP-1, and CYR61 may play a role in the progression of breast cancer and might serve as a valuable tool for monitoring tumor status of breast cancer patients.  (+info)

Progressive pseudorheumatoid dysplasia (PPRD) is a genetic, non-inflammatory arthropathy caused by recessive loss of function mutations in WISP3 (Wnt1-inducible signaling pathway protein 3; MIM 603400), encoding for a signaling protein. The disease is clinically silent at birth and in infancy. It manifests between the age of 3 and 6 years with joint pain and progressive joint stiffness. Affected children are referred to pediatric rheumatologists and orthopedic surgeons; however, signs of inflammation are absent and anti-inflammatory treatment is of little help. Bony enlargement at the interphalangeal joints progresses leading to camptodactyly. Spine involvement develops in late childhood and adolescence leading to short trunk with thoracolumbar kyphosis. Adult height is usually below the 3rd percentile. Radiographic signs are relatively mild. Platyspondyly develops in late childhood and can be the first clue to the diagnosis. Enlargement of the phalangeal metaphyses develops subtly and is ...
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Arthropathy, progressive pseudorheumatoid, of childhood information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Gene Information This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain von Willebrand factor type C module thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia an autosomal recessive skeletal disorder indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul ...
The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How these proteins influence such a range of functions remains incompletely understood but is probably related to their discrete modular nature and a complex array of intra- and inter-molecular interactions with a variety of regulatory proteins and ligands. Although certain aspects of their biology can be attributed to the four individual modules that constitute the CCN proteins, recent results suggest that some of their biological functions require cooperation between modules. Indeed, the modular structure of CCN proteins provides important insight into their structure-function relationships.
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized by the proliferation of fibroblasts and increased deposition of the extracellular matrix. The CCN6/WISP-3 is a member of the CCN family of matricellular proteins, which consists of six members that are involved in many vital biological functions. However, the regulation of lung fibroblasts mediated by CCN6 protein has not been fully elucidated. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin β1, leading to the phosphorylation of FAKY397. Furthermore, CCN6 showed a weak, but significant, ability to stimulate the expression of fibronectin. CCN6 was highly expressed in the lung tissues of mice treated with bleomycin. Our results suggest that CCN6 plays a role in the fibrogenesis of the lungs mainly by stimulating the growth of lung fibroblasts and is a potential target for the treatment of pulmonary fibrosis ...
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
Introduction: CCN1 is so far known as a protein of the extracellular matrix mediating proliferation, adhesion, migration and angiogenesis in an integrin-dependent manner. We recently reported that CCN1 is up-regulated under pathophysiological conditions in the cardiovascular system. Since blood CD34+ progenitor cells have been shown to promote tissue regeneration, we investigated if CCN1 induces angiogenesis by stimulating blood CD34+ cells.. Methods and Results: Circulating CCN1 was detected for the first time in human serum samples (Western blot). Rekombinant CCN1 (100 ng/mL) and supernatants from CCN1-stimulated human CD34+ progenitor cells promoted tube-formation (Matrigel-Assay; P , 0.05; n = 4) and proliferation of endothelial cells (BrdU-incorporation; P , 0.05; n = 4). Moreover, CCN1 significantly induced angiogenesis in the context of blood CD34+ cells in vivo determined in Matrigel implanted into C57/BL6 mice as measured by the hemoglobin content (Drabkins reagent) and by CD31 ...
Fingerprint Dive into the research topics of Protocols for screening for binding partners of CCN proteins: Yeast two-hybrid system. Together they form a unique fingerprint. ...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Inhibition of Delta pH pathway protein transport by antibodies to Hcf106. (A) Maize thylakoids were preincubated with 0.1 mg/ml anti-Hcf106 or preimmune (PI) Ig
View our 12 Cyr61/CCN1 products for your research including Cyr61/CCN1 Primary Antibodies, ELISAs, Proteome Profiler Antibody Arrays, Proteins and Enzymes, and Simple Plex Assays.
CYR61/CCN1 Antibody 26689-1-AP has been identified with ELISA, WB, IF. 26689-1-AP detected 42 kDa band in A431 cells with 1:500-1:3000 dilution...
The p53 pathway is composed of genes and their products that are targeted to respond to stress signals. More than seven negative and three positive feedback loops in the p53 pathway have identified.
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Canonical SMILES: CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl. InChI: InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31). InChI Key: QADPYRIHXKWUSV-UHFFFAOYSA-N ...
Here we describe the isolation and characterization of rCop-1, a novel CCN family protein whose expression was completely lost after cell transformation. Functional studies suggest that rCop-1is a negative regulator for cell transformation based on the following findings. The loss of rCop-1 expression correlates extremely well with cell transformation in culture, since cells transformed by a variety of mechanisms all lost rCop-1 expression. BALB/c A31 and Rat-1 are both immortalized but nontransformed, yet only the former expresses rCop-1. However, both A31 and REFs, the parental cells of Rat-1, lose rCop-1 expression when transformed by a variety of means. This suggests that the loss of rCop-1expression in cultured rodent fibroblasts may not be necessary for cell immortalization but may be so for cell transformation. Efficient retroviral gene transfer of rCop-1 exhibited a dramatic cytotoxic effect on the transformed cells but had little effect on the nontransformed cells.. The first member of ...
WNT1-inducible-signaling pathway protein 2 (WISP2) is primarily expressed in mesenchymal stem cells, fibroblasts, and adipogenic precursor cells. It is both a secreted and cytosolic protein, the latter regulating precursor cell adipogenic commitment and PPARγ induction by BMP4. To examine the effect of the secreted protein, we expressed a full-length and a truncated, non-secreted WISP2 in NIH3T3 fibroblasts. Secreted, but not truncated WISP2 activated the canonical WNT pathway with increased β-catenin levels, its nuclear targeting phosphorylation, and LRP5/6 phosphorylation. It also inhibited Pparg activation and the effect of secreted WISP2 was reversed by the WNT antagonist DICKKOPF-1. Differentiated 3T3-L1 adipose cells were also target cells where extracellular WISP2 activated the canonical WNT pathway, inhibited Pparg and associated adipose genes and, similar to WNT3a, promoted partial dedifferentiation of the cells and the induction of a myofibroblast phenotype with activation of markers ...
Fig. 5. Suppression of CCN1 expression inhibits proliferation of ovarian cancer cells. OVCA433 cells were cotransfected with a small interference RNA construct targeting CCN1 along with a vector containing the puromycin resistance gene; the cells were selected with puromycin. A, Western blot. Cells were harvested daily and analyzed for CCN1 expression. GAPDH was used to control for equal loading and siRNA specificity. B, colony formation assay. Transfected cells were grown for 2 weeks in the presence of puromycin. Colonies were fixed, stained, and photographed. Colonies were dissolved and absorbance (OD) was measured at 600 nm. Columns, means of three independent experiments; bars, SD. C, MTT assay. Transfected cells were used to measure growth in liquid culture by MTT. Points, mean of quadruplicate samples; bars, SD. The experiment was repeated thrice. si-con, control siRNA; si-CCN1, CCN1 siRNA. ...
BMP4 promotes commitment and adipogenic differentiation of precursor cells, whereas canonical WNT activation is inhibitory to both these processes. To make progress in understanding adipogenesis, we need to understand the apparent crosstalk between these pathways.. We recently identified a secreted and WNT-inducible protein, WISP2, as a novel adipokine providing new insight into the crosstalk between WNT and BMP4 signaling (53). WISP2, a member of the CCN family, has previously been found to crosstalk with transforming growth factor-β and to prevent epithelial mesenchymal transformation in cancer cells (54). It is a secreted protein, highly expressed in mesenchymal stem cells and preadipocytes (53). However, it is also present in the cytosol in undifferentiated cells as well as in the nucleus, although mechanisms regulating the subcellular distribution are not known. WISP2 expression is considerably higher in the subcutaneous adipose tissue than in visceral fat, and the expression is positively ...
My research focuses on elucidating the mechanism(s) of cell death and survival of primary alveolar epithelial cells and lung fibroblasts in response to the extracellular matrix associated signaling molecule, CCN1/Cyr61. CCN1/Cyr61 is an extracellular matrix (ECM)-associated signaling molecule that functions to promote cell adhesion, migration, survival and differentiation in the context of vascular development. Most recently we have shown that CCN1/Cyr61 can also modulate cell death in certain cells and can promote cell death in response to TNFa. In the context of the lung, I have found that CCN1/Cyr61 together with TNFa causes apoptosis of alveolar epithelial cells and lung fibroblasts. Because CCN1/Cyr61 has been shown to be induced in the lungs of patients with COPD and ARDS, I hypothesize that CCN1/Cyr61, together with inflammatory mediators such as TNFa causes cell death of primary lung cells in vivo, thus contributing to lung injury. I have also found that CCN1/Cyr61 functional knock-out ...
CCN1 has been shown to promote DNA synthesis and proliferation of various cell types, including prostate epithelial and stromal cells (19). Thus, it is not surprising that endogenous expression of CCN1 elevates cell proliferation in PC-3 and DU-145 cells (Fig. 2). Whereas CCN1 supports endothelial cell survival through interaction with integrin αvβ3, it can also induce apoptosis in some cell types, including fibroblasts, through an α6β1-HSPG-dependent pathway (24, 25). Although CCN1 does not induce cell death in prostatic cells on its own, it cooperates with TRAIL to trigger apoptosis through interaction with integrins αvβ3 and α6β4 and syndecan-4 (Fig. 5). The ability of CCN1 to promote TRAIL-induced cell death in both p53-null (PC-3) and p53 mutant (DU-145) cells indicates that it functions through a p53-independent pathway and suggests that it may be involved in apoptosis of other cancer cells, many of which have lost p53 expression or function. The requirement of multiple CCN1 ...
CCN3 antibody (nephroblastoma overexpressed gene) for ICC/IF, IHC-P, WB. Anti-CCN3 pAb (GTX103377) is tested in Human, Mouse samples. 100% Ab-Assurance.
Expression of WISP2 (CCN5, CT58, CTGF-L) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Rabbit Polyclonal Anti-Cyr61/CCN1 Antibody. Validated: WB, Simple Western, B/N, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Rabbit. 100% Guaranteed.
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CCN2 potentiates PDGF signaling in vascular cellsPDGF-B, created by endothelial cells, and its receptor,PDGFRb expressed in pericytes, are required for
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On Oct 4, 2007, at 2:46 PM, Rajarshi Guha wrote: , Hi, Ive found an error in a recursive smarts for a nitrogen in a , basic amine , , The following SMARTS [NX3;H2,H1;!$(NC=O)] gives 3 hits , for CC1CCCC(C1)N1CCN(CC1)C1CCN(CC1)Cc1ccccc1 whereas it should be 0 Given that in the above structure, the Ns are tertiary, they have no explicit or implicit hydrogens. As a result if I change the SMARTS to [NX3;h2,h1;!$(NC=O)] this works. But the daylight depict match page returns 0 hits for both [NX3;H2,H1;!$(NC=O)] and [NX3;h2,h1;!$(NC=O)] However for c1nc2=NC3=C(C(n2[nH]1)c1cc(cc(c1)F)F)C(=O)CC(C3)c1ccco1 where one of the Ns does have an explicit H, the Daylight page returns a single hit for both forms of the SMARTS The CDK returns 2 hits for the explicit H SMARTS and the correct, single, hit for the implicit H form of the SMARTS. I dont see how it can get 2 hits for the explicit SMARTS form ------------------------------------------------------------------- Rajarshi Guha ,[email protected], GPG Fingerprint: ...
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Canonical SMILES: CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6. InChI: InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31). InChI Key: OUKYUETWWIPKQR-UHFFFAOYSA-N ...
Purpose: : Proliferative vitreoretinopathy (PVR) is a well known complication of ocular trauma and rhegmatogenous retinal detachment leading to progressive deterioration of vision and potential blindness. Although several cell types and cytokines have been detected in PVR membranes their definite pathogenic mechanisms are still unknown. Members of the CCN family of matricellular proteins are multifunctional growth factors representing a novel class of extracellular matrix-associated signalling molecules. Several studies demonstrated that members of the CCN family are involved in the control of cell adhesion, chemotaxis, cell migration and cell proliferation. In particular, it was demonstrated that CTGF, CYR61 and NOV possess fibrotic and angiogenic activity being involved in wound healing and several fibrotic diseases. The aim of the present study was to investigate whether CCN proteins are expressed and increased in epiretinal membranes to shed more light on the pathogenesis of PVR Methods: : ...
Connective tissue growth factor (CCN2) drives fibrogenesis in hepatic stellate cells (HSC). in exosomes however not in cell lysates had been decreased by pre-treatment from the ESI-09 cells using the exosome inhibitor GW4869. ESI-09 Co-culture of miR-214-transfected donor HSC with CCN2 3′-UTR luciferase reporter-transfected receiver HSC led to miR-214- and exosome-dependent rules of a crazy type CCN2 3′-UTR reporter however not of the mutant CCN2 3′-UTR reporter missing the miR-214 binding site. Exosomes from HSC had been a conduit for uptake of miR-214 by major mouse hepatocytes. Down-regulation of CCN2 manifestation by miR-214 also happened in human being LX-2 HSC in keeping with a conserved miR-214 binding site within the human being CCN2 3′-UTR. MiR-214 in LX-2 cells was shuttled via exosomes to receiver LX-2 cells or human being HepG2 hepatocytes leading to suppression of CCN2 3′-UTR activity or manifestation of CCN2 downstream focuses on including αSMA or collagen. Experimental ...
TY - JOUR. T1 - WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast proliferation but inhibits TNF-α-induced cardiomyocyte death. AU - Venkatachalam, Kaliyamurthi. AU - Venkatesan, Balachander. AU - Valente, Anthony J.. AU - Melby, Peter. AU - Nandish, Sailesh. AU - Reusch, Jane E B. AU - Clark, Robert A.. AU - Chandrasekar, Bysani. PY - 2009/5/22. Y1 - 2009/5/22. N2 - WNT1-inducible signaling pathway protein-1 (WISP1), a member of the CYR61/CTGF/Nov family of growth factors, can mediate cell growth, transformation, and survival. Previously we demonstrated that WISP1 is up-regulated in post-infarct heart, stimulates cardiac fibroblast proliferation, and is induced by the proinflammatory cytokine tumor necrosis factor-α (TNF-α). Here we investigated (i) the localization of TNF-α and WISP1 in post-infarct heart, (ii) the mechanism of TNF-α-mediated WISP1 induction in primary human cardiac fibroblasts (CF), (iii) the role of ...
The CCN2 protein is thought to consist of four separate modules. Module 1 is identical to insulin-like growth factor binding protein, module 2 consists of a chordin-like cysteine-rich domain, module 3 is composed of a thrombospondin type 1 domain and module 4 is designated as the CT module or cysteine knot. Modules 1 and 2 make up the N-terminal domain and are linked by a hinge region to the C-terminal domain which is made up of modules 3 and 4 [31, 32]. The ELISA analysis used in our study detects C-terminal CCN2 which translates into detection of both C-terminal fragments and whole CCN2. Our analysis is not able to detect N-terminal CCN2 fragments. Other studies have evaluated the utility of N-terminal CCN2 as a marker of intraocular fibrosis and in scleroderma. In these studies, neither C-terminal nor whole CCN2 were elevated in disease. As as result, it has been postulated that during a fibrotic response, in vivo CCN2 is cleaved resulting in N-terminal fragments which are excreted into the ...
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers. CYR61 was first identified as a protein encoded by a ...
TY - JOUR. T1 - Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes. AU - Nishida, Takashi. AU - Kubota, Satoshi. AU - Aoyama, Eriko. AU - Janune, Danilo. AU - Maeda, Azusa. AU - Takigawa, Masaharu. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2011/11. Y1 - 2011/11. N2 - CCN2 (also known as connective tissue growth factor) interacts with several growth factors involved in endochondral ossification via its characteristic four modules and modifies the effect of such growth factors. Presently we investigated whether CCN2 interacts with fibroblast growth factor 2 (FGF2). Solid-phase binding assay, immunoprecipitation-Western blot analysis, and surface plasmon resonance (SPR) spectroscopy revealed that the C-terminal module of CCN2 (CT) directly bound to FGF2 with a dissociation constant of 5.5 nM. Next, we examined the combinational effects of CCN2 and FGF2 on the proliferation of and matrix metalloproteinase (MMP)-9 and -13 ...
Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) prot …
The extracellular matrix plays critical roles in regulating diverse biological and pathological processes, including developmental morphogenesis, tissue repair and remodeling, inflammation and host defense, and progression of diseases such as cancer. Our laboratory is interested in the biological functions of CCNs, a family of cysteine-rich, dynamically expressed matricellular proteins that regulates a broad range of cellular activities through direct binding to integrin receptors and heparan sulfate proteoglycans. Ccn1- and Ccn2-null mice are embryonic and perinatal lethal due to cardiovascular and skeletal defects, respectively, underscoring the importance of these matrix proteins. In addition, aberrant expression of Ccn1 and Ccn2 is associated with pathological conditions including wound healing, atherosclerosis, restenosis, rheumatoid arthritis, and cancer.. Our current studies aim to understand how CCN proteins function through integrin-mediated signaling to regulate diverse processes, ...
CYR61-CTGF-NOV (CCN)1 is a dynamically expressed extracellular matrix (ECM) protein with critical functions in cardiovascular development and tissue repair. Angiogenic endothelial cells (ECs) are a major cellular source of CCN1 which, once secreted, associates with the ECM and the cell surface and t …
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Expression of WISP2 (CCN5, CT58, CTGF-L) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Rabbit Polyclonal Anti-Cyr61/CCN1 Antibody [Biotin]. Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Rabbit. 100% Guaranteed.
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Smiles: CCC3NC(=O)C(NC(=O)c1ncccc1(O))C(C)OC(=O)C(NC(=O)C5CC(=O)CCN5(C(=O)C(Cc2ccc(cc2)N(C)C)N(C)C(=O)C4CCCN4(C3(=O))))c6ccccc6 ...
LRP1 is known to be a receptor for signal transmission and endocytosis. We formerly reported that LRP1 regulates WNT/β-catenin and protein kinase C signaling in chondrocytes and represses the hypertrophy of chondrocytes during endochondral ossification, and that LRP1 is co-localized with a ligand, CCN2, which conducts endochondral ossification, on chondrocytes. However, the role of LRP1 in endocytotic transport of CCN2 in chondrocytes is not yet understood. In the present study, we investigated the interaction between LRP1 and CCN2 during endocytotic trafficking.. RNAi-mediated knockdown of LRP1 in chondrocytic HCS-2/8 cells showed that the amount of exogenous CCN2 binding/incorporation was decreased in the LRP1 down-regulated cells. Importantly, we observed that CCN2 internalization in chondrocytes was dependent on clathrin and internalizated CCN2 was co-localized with an early or recycling endosome marker. Transcytosis of CCN2 through HCS-2/8 cells was confirmed by performing experiments with ...
CCN benefits patients and family members by providing information, resources and facts on adult cardiac care and access to cardiac care treatment centres throughout the province.. In addition to helping to plan, coordinate, implement and evaluate cardiovascular care in Ontario, CCN is responsible for developing, maintaining and reporting on the provincial cardiac wait list registry for all patients waiting for selected adult advanced cardiac procedures.. In the role of monitoring and enhancing the quality, equity and access of cardiac services in Ontario, CCN develops strategies, based on best practices, to better manage cardiovascular disease across the continuum of care, including strategies to prevent acute hospital readmissions, decrease demand on emergency departments and decrease the need for initial and repeat procedures.. ...
Data Availability StatementAll data generated or analyzed in this scholarly research are contained in the present content. and impacting the cell routine. This development inhibitory effect due to WISP2 loss is because of the inhibition of phosphorylated extracellular signal-related kinase (p-ERK)1/2, aswell as CCAAT/enhancer-binding proteins (CEBP) and CEPB. Furthermore, WISP2 deletion also turned on the Yes-associated protein (YAP). Summary WISP2 deletion inhibits ovarian malignancy cell proliferation by influencing ERK signaling pathways. (CEBP) and CEBP. In addition, WISP2 deletion also triggered the Yes-associated protein (YAP). The current study exposed the potential of WISP2 as a factor capable of advertising ovarian malignancy cell proliferation and survival. Results WISP2 is definitely overexpressed in human being ovarian malignancy cells and cell lines WISP2 protein manifestation in human normal ovary cells and ovarian malignancy tissues was assessed via immunohistochemistry. WISP2 was ...
Wheat is related to a large number of other species many of which are wild and uncultivated. These wild relatives, unlike wheat, provide a vast and largely untapped reservoir of genetic variation for potentially most, if not all, agronomically important traits, which can be used in the development of new higher yielding varieties, adapted to the changing environment.. The primary objective of the Nottingham/BBSRC Wheat Research Centre (WRC) at Sutton Bonington is to transfer genetic variation for agronomically and scientifically important traits from wild and distantly related species into wheat and to distribute the germplasm generated world wide for exploitation in breeding programmes and in scientific research. The WRCs research, which is part of the WISP Programme, is underpinned by funding from the BBSRC and Nottingham University in addition to a range of other funders from both the public and private sectors. Key collaborators include JIC, the University of Bristol, Rothamsted Research, ...
nephroblastoma: Malignant renal (kidney) tumour of early childhood. In 75 percent of the cases, the tumour grows before the age of five; about two-thirds of the instances are apparent by two years...
Affiliation:埼玉医科大学,医学部,准教授, Research Field:Kidney internal medicine,Radiation science,Urology, Keywords:腎線維化,CCN2,線維化,慢性腎臓病,尿細管上皮細胞,遺伝子改変動物,線維芽細胞,CKD,急性腎障害(AKI),転移性腎癌, # of Research Projects:6, # of Research Products:18, Ongoing Project:CCN2機能制御による慢性腎臓病の新規治療法の開発
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... associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad ... Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines". J. Cell Commun. Signal ...
... associated signaling proteins (see also CCN intercellular signaling protein). The CCN acronym is derived from the first three ... These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six-member CCN family in vertebrates ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Chen CC, Lau LF (Apr 2009). "Functions and mechanisms of action of CCN matricellular proteins". The International Journal of ...
... see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, ... is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins ( ... Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich ... Chen CC, Lau LF (April 2009). "Functions and mechanisms of action of CCN matricellular proteins". Int. J. Biochem. Cell Biol. ...
... the first three proteins identified that belong to the "CCN" protein family - also see CCN intercellular signaling protein ... CCN may refer to: Cement chemist notation, developed to simplify the formulas used by cement chemists Cereal cyst nematode, a ... see Nutrition This disambiguation page lists articles associated with the title CCN. If an internal link led you here, you may ...
CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their ... CCN proteins likely constitute a hub for the coordination of cell signaling and communication. The CCN protein family includes ... 4(5), 477-494, DOI: 10.1515/bmc-2013-0018, CCN+Intercellular+Signaling+Proteins at the US National Library of Medicine Medical ... WNT1 inducible signaling pathway protein-2) CCN6: WISP3 (WNT1 inducible signaling pathway protein-3) Jun JI, Lau LF (December ...
Examples of matricellular proteins include the CCN family of proteins (also known as CCN intercellular signaling protein), ... Many of these proteins have important functions in wound healing and tissue repair. CCN protein Bornstein P (August 1995). " ... Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nat Rev ... A matricellular protein is a dynamically expressed non-structural protein that is present in the extracellular matrix (ECM). ...
... associated signaling proteins (CCN intercellular signaling protein). The CCN family of proteins shares a common molecular ... WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded ... WISP1 WNT1 inducible signaling pathway protein 1". Chen CC, Lau LF (Apr 2009). "Functions and mechanisms of action of CCN ... Jun JI, Lau LF (Dec 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nature ...
CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. The ... comprise the six-member CCN family in vertebrates. CCN proteins characteristically contain an N-terminal secretory signal ... WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the ... The CCN family of proteins regulates diverse cellular functions, including cell adhesion, migration, proliferation, survival, ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... G-protein coupled receptor signaling pathway. • bone mineralization. • negative regulation of chondrocyte development. ... Parathyroid hormone-related protein (or PTHrP) is a protein member of the parathyroid hormone family. It is occasionally ... adenylate cyclase-activating G-protein coupled receptor signaling pathway. • cAMP metabolic process. • positive regulation of ...
CCN intercellular signaling protein *Cysteine-rich protein 61. *Connective tissue growth factor ... Protein-binding assays in biological liquids using microscale thermophoresis. Nature Communications. 2010, 1 (7): 100. Bibcode: ... BindingDB, a public database of measured protein-ligand binding affinities.. *BioLiP, a comprehensive database for ligand- ... Teif VB, Rippe K. Statistical-mechanical lattice models for protein-DNA binding in chromatin.. Journal of Physics: Condensed ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... cell-cell signaling. • ephrin receptor signaling pathway. • axon guidance. • osteoclast differentiation. • bone remodeling. ... Three transcript variants that encode distinct proteins have been identified.[6] References[edit]. *^ a b c GRCh38: Ensembl ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. ... In DNA-ligand binding studies, the ligand can be a small molecule, ion,[1] or protein[2] which binds to the DNA double helix. ... Teif VB, Rippe K (October 2010). "Statistical-mechanical lattice models for protein-DNA binding in chromatin". Journal of ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... Reverse signaling in growth cone survival[edit]. "Reverse" signaling is one unique property of ephrin ligands that allows for ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... protein binding. Cellular component. • membrane. • plasma membrane. • anchored component of external side of plasma membrane. • ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... Receptor/signaling modulators. Signaling peptide/protein receptor modulators. Growth factor receptor modulators. Cytokine ... These proteins interact with a conserved family of cell surface serine/threonine-specific protein kinase receptors, and ... Human genes encoding proteins that contain this domain include:. AMH; ARTN; BMP10; BMP15; BMP2; BMP3; BMP4; BMP5; BMP6; BMP7; ...
0 (CCN Intercellular Signaling Proteins); 0 (CYR61 protein, human); 0 (Cysteine-Rich Protein 61); 0 (Insulin-Like Growth Factor ... Repressor Proteins); 0 (WISP1 protein, human); 0 (WISP2 protein, human); 0 (insulin-like growth factor binding protein-related ... NOV protein, human); 0 (Nephroblastoma Overexpressed Protein); 0 (Proto-Oncogene Proteins); 0 ( ... 0RH81L854J (Glutamine); EC 1.4.1.2 (Glutamate Dehydrogenase); EC 1.4.1.3 (GLUD1 protein, human); EC 3.5.1.- (SIRT5 protein, ...
CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their ... CCN proteins likely constitute a hub for the coordination of cell signaling and communication. The CCN protein family includes ... 4(5), 477-494, DOI: 10.1515/bmc-2013-0018, CCN+Intercellular+Signaling+Proteins at the US National Library of Medicine Medical ... WNT1 inducible signaling pathway protein-2) CCN6: WISP3 (WNT1 inducible signaling pathway protein-3) Jun JI, Lau LF (December ...
... associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad ... Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines". J. Cell Commun. Signal ...
Protein Binding. 3. 2011. 1224. 0.110. Why? CCN Intercellular Signaling Proteins. 1 ...
CCN Intercellular Signaling Proteins 7 Citations (Scopus) * The Role of Central Nervous System Mechanisms in Resistant ... Wells, J. E., Howlett, M., Cheung, L. C. & Kees, U. R., 29 Sep 2015, In : Journal of Cell Communication and Signaling. 9, 3, p ... The role of CCN family genes in haematological malignancies. ...
CCN Intercellular Signaling Proteins 100% * Cloning 74% * Escherichia coli 70% * Purification 62% ... Cloning, expression and purification of the CCN family of proteins in Escherichia coli. Holbourn, K. P. & Acharya, K. R., 22 ...
CCN6 is a cysteine-rich protein that belongs to the CCN (Cyr61, CTGF, and Nov) family of matricellular proteins. However, the ... Dec, 2012 , Pubmed ID: 23237992 Suppressor of cytokine signaling 1 (SOCS1) and suppressor of cytokine signaling 3 (SOCS3) have ... In this study, we found that CCN6 increased the migration and the expression of intercellular adhesion molecule-1 (ICAM-1) in ... Feb, 2009 , Pubmed ID: 19126648 Cysteine-rich 61 (Cyr61), from the CCN gene family, is a secreted and matrix-associated protein ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... G-protein coupled receptor signaling pathway. • bone mineralization. • negative regulation of chondrocyte development. ... Parathyroid hormone-related protein (or PTHrP) is a protein member of the parathyroid hormone family. It is occasionally ... adenylate cyclase-activating G-protein coupled receptor signaling pathway. • cAMP metabolic process. • positive regulation of ...
Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the ... Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the ... Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the ... Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the ...
Analysis of signaling pathways activated by CCN proteins. Kawaki, H., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in ... The ccn proteins: An overview. Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 1-8 8 p. (Methods ... Elisa of CCN family proteins in body fluids including serum and plasma. Kubota, S., Kawaki, H. & Takigawa, M., Jan 1 2017, ... treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration ...
CCN Intercellular Signaling Proteins Entry term(s). CCN Family Proteins CYR61 CTGF NOV Matricellular Proteins Matricellular CCN ... CCN Intercellular Signaling Proteins - Preferred Concept UI. M0518136. Scope note. A family of secreted proteins found ... CCN Family Proteins. CYR61 CTGF NOV Matricellular Proteins. Matricellular CCN Proteins. Tree number(s):. D12.644.276.200. ... The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and ...
CCN Intercellular Signaling Proteins 23 Citations (Scopus) * 2013 A novel vibratory stimulation-based occlusal splint for ... bone formation in a swine socket lift model using escherichia coli-derived recombinant human bone morphogenetic protein-2 ...
ECM Proteins) are macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur ... Cartilage Oligomeric Matrix Protein *CCN Intercellular Signaling Proteins *Connective Tissue Growth Factor *Cysteine-Rich ... ADAMTS Proteins *ADAMTS1 Protein *ADAMTS4 Protein *ADAMTS5 Protein *ADAMTS7 Protein *ADAMTS9 Protein *ADAMTS13 Protein * ... ECM Proteins ⌊Compounds of Life. ⌊Proteins (Protein Science). ⌊Physiological related proteins. ⌊Scleroproteins. ⌊Extracellular ...
CCN Intercellular Signaling Proteins Concept HEK293 Cells Concept Adaptor Proteins, Signal Transducing ... The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis. ... Neural EGF-like protein 1 (NELL-1): Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine. ... BMP signaling in mesenchymal stem cell differentiation and bone formation. Academic Article Wnt/ß-catenin signaling plays an ...
Agouti signaling protein * Agouti-related protein * Angiogenic protein * CCN intercellular signaling protein * Cysteine-rich ... cAMP-dependent pathway · Ca2+ signaling · Lipid signaling · IP3/DAG pathway. Assistants: Signal transducing adaptor protein · ... Signaling pathways. GPCR (Hedgehog, Wnt) · RTK (TGF beta, MAPK/ERK) · Notch · JAK-STAT · Akt/PKB · Fas apoptosis · Hippo · PI3K ... Signaling molecules · Intracrine action · Ion channel gating · Mechanotransduction · Phototransduction · Synaptic transmission ...
Immediate-Early Proteins. *Intercellular Signaling Peptides and Proteins. *Nephroblastoma Overexpressed Protein. *RNA, ... CCN gene expression levels were studied at the mRNA and protein level in retinas of control and diabetic rats using real-time ... Referred to as CCN, the family of growth factors consisting of cystein-rich protein 61 (CYR61, also known as CCN1), connective ... Gene expression of CCN family members. Fold change, compared with control values, in retinal mRNA levels of CCN family members ...
CCN Intercellular Signaling Proteins , Child , Humans , INDEL Mutation , Insulin-Like Growth Factor Binding Proteins , Genetics ... Animals , CCN Intercellular Signaling Proteins , Metabolism , Drugs, Chinese Herbal , Pharmacology , Glucosamine , Pharmacology ... CCN Intercellular Signaling Proteins , Metabolism , Cells, Cultured , Coculture Techniques , Fibroblasts , Cell Biology , ... Actins , Metabolism , CCN Intercellular Signaling Proteins , Metabolism , Cell Line , Collagen Type I , Metabolism , Connective ...
CCN Intercellular Signaling Proteins 20% 20 Scopus citations * 2010 A novel mechanism of acid and bile acid-induced DNA damage ... The matrix protein CCN1/CYR61 is required for αVβ5-mediated cancer cell migration. Jandova, J., Beyer, T. E., Meuillet, E. J. ... Expression of bile acid transporting proteins in Barretts esophagus and esophageal adenocarcinoma. Dvorak, K., Watts, G. S., ... Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen Zearalenone-induced cell-cycle progression in ...
CCN intercellular signaling protein *Cysteine-rich protein 61. *Connective tissue growth factor ... Protein-binding assays in biological liquids using microscale thermophoresis. Nature Communications. 2010, 1 (7): 100. Bibcode: ... BindingDB, a public database of measured protein-ligand binding affinities.. *BioLiP, a comprehensive database for ligand- ... Teif VB, Rippe K. Statistical-mechanical lattice models for protein-DNA binding in chromatin.. Journal of Physics: Condensed ...
Agouti Signaling Protein. *Agouti-Related Protein. *Angiogenic Proteins. *B7 Antigens. *CCN Intercellular Signaling Proteins ... A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of ... As a paracrine signaling molecule, AGRP is known to regulate food intake and body weight. Elevated AGRP has been associated ... "Agouti-Related Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
Mechanistically, TRAF6 mediated the protein stability of STAT6, a key factor in IL-4 signaling. Overexpression of TRAF6 ... The inhibition of PI3K/Akt signalling decreased the expressions of Cx43 and thus impaired gap junction intercellular ... MATERIALS AND METHODS: qPCR was performed to determine the expression of gene profile in the CCN family in chondrocytes. After ... signaling regulation of SSCs extended from embryonic development, and signal molecule delivery for the repair of the ...
Agouti Signaling Protein. *Agouti-Related Protein. *Angiogenic Proteins. *B7 Antigens. *CCN Intercellular Signaling Proteins ... A family of proteins that mediate axonal guidance. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to ... Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons. Handb Clin ...
CCN Intercellular Signaling Proteins. *Cell Adhesion Molecules, Neuronal. *Cell Differentiation. *Cell Line ...
Agouti signaling protein. *Agouti-related protein. *Angiogenic protein. *CCN intercellular signaling protein *Cysteine-rich ... cell-cell signaling. • ephrin receptor signaling pathway. • axon guidance. • osteoclast differentiation. • bone remodeling. ... Three transcript variants that encode distinct proteins have been identified.[6] References[edit]. *^ a b c GRCh38: Ensembl ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...
CCN Intercellular Signaling ProteinsConnective Tissue Growth FactorCysteine-Rich Protein 61Nephroblastoma Overexpressed Protein ... and ProteinsProteinsIntercellular Signaling Peptides and ProteinsAdipokinesAdiponectinLeptinResistinAgouti-Related Protein ... FactorsTransforming Growth Factor alphaWnt ProteinsWnt-5a ProteinWnt1 ProteinWnt2 ProteinWnt3 ProteinWnt3A ProteinWnt4 Protein ... FactorsTransforming Growth Factor alphaWnt ProteinsWnt-5a ProteinWnt1 ProteinWnt2 ProteinWnt3 ProteinWnt3A ProteinWnt4 Protein ...
ADAMTS Proteins. *Aggrecans. *Cartilage Oligomeric Matrix Protein. *CCN Intercellular Signaling Proteins. *Collagen ...
CCN Intercellular Signaling Proteins. *CCN6 protein, human. *RNA, Messenger. Supplementary concept. *Arthropathy, progressive ... PPRD is due to a mutation in Wnt1-inducible signalling protein 3 (WISP3) gene, which encodes a signalling factor involved in ...
CCN Intercellular Signaling Proteins. Proteínas de Sinalização Intercelular CCN. Proteínas CCN de Señalización Intercelular. ... CCN Intercellular Signaling Proteins. Proteínas de Sinalização Intercelular CCN. Proteínas CCN de Señalización Intercelular. ... Nodal Protein. Proteína Nodal. Proteína Nodal. Nodal Signaling Ligands. Ligantes da Sinalização Nodal. Ligandos de Señalización ... Nodal Protein. Proteína Nodal. Proteína Nodal. Nodal Signaling Ligands. Ligantes da Sinalização Nodal. Ligandos de Señalización ...
CCN Intercellular Signaling Proteins. *CCN4 protein, human. *CTNNB1 protein, human. *Intercellular Signaling Peptides and ... Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han ... Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han ... Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han ...
ADAMTS Proteins. *Aggrecans. *Cartilage Oligomeric Matrix Protein. *CCN Intercellular Signaling Proteins. *Collagen ... These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the ... "Extracellular Matrix Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Extracellular Matrix Proteins" by people in this website by ...
  • and -kinos , movement) is the name used to describe a diverse group of soluble proteins , peptides , or glycoproteins which act as hormonal regulators or signaling molecules at nano- to- picomolar concentrations and help in cell signaling . (hawaiilibrary.net)
  • Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. (nih.gov)
  • Inhibition of the Wnt-ß-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. (rush.edu)
  • VEGFR and its downstream signaling pathways including p-ERK, p-P38, and p-Akt were more in HPVECs with YAP overexpression. (frontiersin.org)
  • Since ephrin ligands (ephrins) and Eph receptors (Ephs) are both membrane-bound proteins , binding and activation of Eph/ephrin intracellular signaling pathways can only occur via direct cell-cell interaction . (readtiger.com)
  • The IGF-2 receptor only binds IGF-2 and acts as a "clearance receptor"-it activates no intracellular signaling pathways, functioning only as an IGF-2 sequestering agent and preventing IGF-2 signaling. (ipfs.io)
  • CamKII, CaM kinase II) A signaling protein serine/threonine protein kinase in pathways that use calcium ions Ca(2+) as a second messenger. (edu.au)
  • The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic dise. (biomedcentral.com)
  • Based on in vitro studies, TIE2-R849W is thought to lead to constitutive ligand-independent hyperphosphorylation of mutant TIE2, thereby activating downstream signaling pathways and enhancing corresponding cell functions[ 5 , 8 ]. (medsci.org)
  • Here, we report that Yap, the Hippo pathway effector, is a chief player in this process: functionally manipulating Yap during regeneration dramatically affects cell proliferation and expression of key signaling pathways, impacting regenerative growth. (biologists.org)
  • necessary seconds in available download A Sudden proteins are digital pathways into the 69The populations of LEM-domain symbols, positions, and their bottom in Christian campaigns. (dollyworldwide.com)
  • We found evidence for a bidirectional regulating system with paracrine signalling pathways between periosteum and articular chondrocytes [extremely likely that this signaling pathway is shared by epiphyseal chondrocytes as well]. (heightquest.com)
  • The acronym CCN is derived from the first three members of the family discovered, namely CYR61 (cysteine-rich angiogenic protein 61 or CCN1), CTGF (connective tissue growth factor or CCN2), and NOV (nephroblastoma overexpressed or CCN3). (wikipedia.org)
  • The CCN protein family includes the following six proteins: CCN1: CYR61 (cysteine-rich angiogenic protein 61) CCN2: CTGF (connective tissue growth factor) CCN3: NOV (nephroblastoma overexpressed) CCN4: WISP1 (WNT1 inducible signaling pathway protein-1) CCN5: WISP2 (WNT1 inducible signaling pathway protein-2) CCN6: WISP3 (WNT1 inducible signaling pathway protein-3) Jun JI, Lau LF (December 2011). (wikipedia.org)
  • Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. (nih.gov)
  • Connective Tissue Growth Factor (CTGF) a member of the Cyr 61 CTGF Nov (CCN) family of proteins regulates multiple cellular functions. (healthconnectionsvt.org)
  • It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. (wikipedia.org)
  • RESULTS: The CTGF (CCN2) was shown to be the highest expressed member of the CCN family in chondrocytes. (bvsalud.org)
  • It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) proteins. (nih.gov)
  • Moreover, gene expression levels and the effects of exogenous CCN proteins on chondrocyte proliferation, differentiation, and the expression of chondrocyte-associated genes in their primary chondrocytes were evaluated. (elsevier.com)
  • Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population. (cdc.gov)
  • The genes that encode the ephrin-A and ephrin-B proteins are designated as EFNA and EFNB respectively. (readtiger.com)
  • Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. (biomedcentral.com)
  • In particular, genes downstream of Hippo signaling and the biomechanical sensor and transcriptional coactivator Yes-associated protein (YAP) were downregulated in infected endothelial cells. (asm.org)
  • WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the WISP3 gene. (wikipedia.org)
  • PPRD is due to a mutation in Wnt1-inducible signalling protein 3 (WISP3) gene, which encodes a signalling factor involved in cartilage homeostasis. (cdc.gov)
  • Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the two types of mice. (elsevier.com)
  • Muscular dystrophies are a group of conditions in which muscle dysfunction is either due to defective structural proteins or to genetic mutations affecting signaling molecules and enzymes. (lidsen.com)
  • Among activated downstream molecules, PI3K, ShcA protein and STAT1 are all confirmed to be involved in the TIE2-R849W related network[ 10 , 11 ]. (medsci.org)
  • The role of intercellular communication in the regulation of bacterial multicellular behavior has received widespread attention, and a variety of signal molecules involved in bacterial communication have been discovered. (columbiagypsy.net)
  • Inhibition of ICAM-1/CD18 signaling suppresses but does not completely abolish the cardinal manifestations of diabetic retinopathy, suggesting a role for additional adhesion molecules. (arvojournals.org)
  • Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina. (nih.gov)
  • CCN gene expression levels were studied at the mRNA and protein level in retinas of control and diabetic rats using real-time quantitative PCR, western blotting and immunohistochemistry at 6 and 12 weeks of streptozotocin-induced diabetes in the presence or absence of aminoguanidine, an AGE inhibitor. (nih.gov)
  • Gene expression of CCN family members. (nih.gov)
  • MATERIALS AND METHODS: qPCR was performed to determine the expression of gene profile in the CCN family in chondrocytes. (bvsalud.org)
  • Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene . (wikipedia.org)
  • AgRP is a paracrine signalling molecule made up of 112 amino acids (the gene product of 132 amino acids is processed by removal of the N-terminal 20-residue signal peptide domain). (wikidoc.org)
  • RNA sequencing (RNA-Seq) comparing genome-wide transcriptional profiles of infected to uninfected endothelial cells revealed changes in gene expression associated with cell-cell adhesion, extracellular matrix reorganization, and cytokine-mediated signaling. (asm.org)
  • Interestingly, T. gondii infection activated Hippo signaling by increasing phosphorylation of LATS1, leading to cytoplasmic retention of YAP, and reducing YAP target gene expression. (asm.org)
  • Virus-induced gene silencing of NRL1 in N. benthamiana resulted in reduced P. infestans colonization and accelerated INF1-mediated cell death, indicating that this host protein acts as a negative regulator of immunity. (plantphysiol.org)
  • Transcriptome profiles were generated for macular and extramacular regions, and statistical and bioinformatic methods were employed to identify disease-associated gene signatures and functionally enriched protein association networks. (biomedcentral.com)
  • have already been determined in the epithelia from the lungs and uterus the choroid plexus as well as the center [5 6 Translation from the PMP22 gene provides rise to a 160-amino-acid proteins with four forecasted transmembrane domains. (gobreastcancer.info)
  • Actually PMP22 was initially discovered being a gene upregulated in growth-arrested fibroblasts in lifestyle [14] and since that time PMP22 proteins has been proven to greatly help regulate cell growing JNJ-26481585 and regulate apoptosis in these cells JNJ-26481585 [15]. (gobreastcancer.info)
  • The expression of COL2A1, melanoma inhibitory activity (cartilage-derived retinoic acid-sensitive protein) [MIA (CD-RAP)] and aggrecan was mainly unaffected by culture conditions, whereas COL1A1 gene expression was increased in periosteal paracrine cocultures. (heightquest.com)
  • Stimulation of TGF-beta1 and COL1A1 gene expression in periosteal paracrine cocultures and the increased release of TGF-beta1 protein in physical contact conditions indicate an anabolic, and not merely chondrogenic micro-environment in this in vitro model for periosteal-based ACI. (heightquest.com)
  • A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of MELANOCORTIN RECEPTOR activity. (harvard.edu)
  • A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. (uchicago.edu)
  • The murine homologue of AgRP consists of 111 amino acids (precursor is 131 amino acids) and shares 81% amino acid identity with the human protein. (wikidoc.org)
  • Eph/ephrin signaling regulates a variety of biological processes during embryonic development including the guidance of axon growth cones , [1] formation of tissue boundaries, [2] cell migration , and segmentation . (readtiger.com)
  • SPARC (Secreted Protein Acidic and Rich in Cysteine), a secreted glycoprotein, regulates proliferation, migration and differentiation. (ubc.ca)
  • DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. (antibody-antibodies.com)
  • Due to their dynamic role within the ECM they are considered matricellular proteins. (wikipedia.org)
  • Together with three Wnt-induced secreted proteins, they comprise the CCN family of matricellular proteins. (wikipedia.org)
  • PTHrP is critical in intraosseous phase of tooth eruption where it acts as a signalling molecule to stimulate local bone resorption. (wikipedia.org)
  • In our body, as a specific CD antigen , Activated-Leukocyte Cell Adhesion Molecule (ALCAM) , aka CD166 antigens (CD6 ligand), is a extracellular matrix protein that acts as a cell adhesion molecule, expressed on activated leukocytes, fibroblasts, and neurons. (wellnessadvocate.com)
  • As a paracrine signaling molecule, AGRP is known to regulate food intake and body weight. (harvard.edu)
  • This review focuses on the bold ideas and recent findings on newly identified skeletal stem cells (SSCs) as candidates for craniofacial regeneration, signaling regulation of SSCs extended from embryonic development, and signal molecule delivery for the repair of the craniofacial defect, sincerely hoping that the hypothesis of craniofacial self-healing is true in the future. (bvsalud.org)
  • Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase -meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. (ipfs.io)
  • Previous study of the bleomycin-induced lung injury model suggested that (111)In-labeled antirat intercellular adhesion molecule-1 (aICAM-1) might be a useful acute respiratory distress syndrome (ARDS) diagnostic agent. (prednisone2020.site)
  • Both Wnt/beta-catenin and bone morphogenetic proteins (BMPs) have been considered as important regulators of osteogenic differentiation of mesenchymal stem cells. (uchicago.edu)
  • Id proteins) and CTGF. (uchicago.edu)
  • CTGF facilitated functional gap junction intercellular communication in chondrocytes through up-regulation of Cx43 expressions. (bvsalud.org)
  • CTGF activated PI3K/Akt signalling to promote Akt phosphorylation and translocation. (bvsalud.org)
  • The inhibition of PI3K/Akt signalling decreased the expressions of Cx43 and thus impaired gap junction intercellular communication enhanced by CTGF. (bvsalud.org)
  • CONCLUSIONS: For the first time, we provide evidence to show CTGF facilitates cell communication in chondrocytes via PI3K/Akt signalling pathway. (bvsalud.org)
  • The molecular mechanism by which CTGF or other CCN proteins regulate cell signalling is not known. (nih.gov)
  • CTGF contains a cysteine-rich domain (CR) similar to those found in chordin and other secreted proteins, which in some cases have been reported to function as bone morphogenetic protein (BMP) and TGF-beta binding domains. (nih.gov)
  • These results show that CTGF inhibits BMP and activates TGF-beta signals by direct binding in the extracellular space. (nih.gov)
  • CTGF improved the mRNA levels of by mechanisms self-employed of BMP or Wnt signaling. (healthconnectionsvt.org)
  • In addition CTGF triggered Nuclear Element of Activated T-cells (NFAT) signaling in osteoblasts even though mechanisms were not explored (Smerdel-Ramoya et al. (healthconnectionsvt.org)
  • To determine if a cause-effect interaction exists, we used semi-quantitative in situ hybridisation to analyse patterns of CTGF and P450 arom mRNA expression and immunohistochemistry to detect CTGF protein localisation throughout follicular development, and tested the actions of CTGF on oestrogen biosynthesis and oestradiol on CTGF mRNA expression in isolated GC in vitro . (bioscientifica.com)
  • Immunohistochemistry showed CTGF protein localisation broadly followed mRNA expression during follicular development, although the protein was also present in the theca interna and ovarian surface epithelium. (bioscientifica.com)
  • Gradients in CTGF expression across the cumulus oophorus and follicle wall were similar to those observed for mRNA with CTGF protein expression being greatest in proximity to the oocyte. (bioscientifica.com)
  • However, little is known concerning roles of the other CCN members in chondrocytes. (elsevier.com)
  • Agouti-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Agouti-Related Protein" by people in Harvard Catalyst Profiles by year, and whether "Agouti-Related Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Agouti-Related Protein" by people in Profiles. (harvard.edu)
  • Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice. (harvard.edu)
  • Agouti-related protein ( AgRP ), also called agouti-related peptide , is a neuropeptide produced in the brain by the AgRP/NPY neuron. (wikidoc.org)
  • Agouti-related protein is expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with lower levels of expression in the testis, kidneys, and lungs. (wikidoc.org)
  • These receptors are activated by the peptide hormone α-MSH (melanocyte-stimulating hormone) and antagonized by the agouti-related protein. (wikidoc.org)
  • It has been suggested that Agouti-related protein binds MSH receptors and acts as a competitive antagonist of ligand binding . (wikidoc.org)
  • These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. (wikipedia.org)
  • The mRNA levels of Dickkopf homolog 1(DKK1), Wnt induced secreted protein 1(WISP1), Wnt1, low density lipoprotein receptor related protein 5(LRP5) and beta -catenin in rats cartilaginous tissues were analyzed by using RT-PCR method, and the protein contents of DKK1, WISP1, Wnt1, LRP5 and beta-catenin in cartilaginous tissues were detected by Western blot. (bvsalud.org)
  • Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. (biomedcentral.com)
  • Inhibition of this signaling pathway may hold promise for clinical activity in patients with diabetes. (arvojournals.org)
  • CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. (wikipedia.org)
  • Members of the CCN protein family are characterized by having four conserved cysteine-rich domains, which include the insulin-like growth factor-binding domain (IGFBP), the Von Willebrand factor type C domain (VWC), the thrombospondin type 1 repeat (TSR), and a C-terminal domain (CT) with a cysteine knot motif. (wikipedia.org)
  • The CCN family: a new class of inflammation modulators? (wikipedia.org)
  • Satoshi Kubota, Masaharu Takigawa (2013) CCN family acting throughout the body: recent research developments. (wikipedia.org)
  • Parathyroid hormone-related protein (or PTHrP ) is a protein member of the parathyroid hormone family . (wikipedia.org)
  • CCN2 is best known as a promoter of chondrocyte differentiation among the CCN family members, and its null mice display skeletal dysmorphisms. (elsevier.com)
  • A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. (bvsalud.org)
  • We hypothesised that pathological effects of AGEs in the diabetic retina are a consequence of AGE-induced alterations in CCN family expression. (nih.gov)
  • Fold change, compared with control values, in retinal mRNA levels of CCN family members in streptozotocin-induced diabetic rats at 6 ( white bars ) and 12 weeks ( cross-hatched bars ) after streptozotocin-induction and in aminoguanidine-treated, streptozotocin-induced diabetic rats at 6 ( black bars ) and 12 weeks ( grey bars ) of diabetes. (nih.gov)
  • A family of proteins that mediate axonal guidance. (harvard.edu)
  • A family of intercellular signaling proteins that play and important role in regulating the development of many TISSUES and organs. (rush.edu)
  • A large family of cell regulatory proteins which are structurally related to TRANSFORMING GROWTH FACTOR BETA. (sickkids.ca)
  • Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins ) are a family of proteins that serve as the ligands of the eph receptor . (readtiger.com)
  • This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands ( Insulin-like growth factor 1 (IGF-1) and Insulin-like growth factor 2 (IGF-2)), a family of six high-affinity IGF-binding proteins (IGFBP-1 to IGFBP-6), as well as associated IGFBP degrading enzymes , referred to collectively as proteases . (ipfs.io)
  • IGF-1 and IGF-2 are regulated by a family of proteins known as the IGF-Binding Proteins . (ipfs.io)
  • Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein, a member of the bactericidal/permeability-increasing protein (BPI) family, is expressed in human nasopharyngeal and respiratory epithelium [ 1 , 2 ] and is also referred to as BPI fold containing family A, member 1 (BPIFA1) [ 3 ]. (plos.org)
  • Using reverse transcription-polymerase chain reaction, western blot analysis, and immunohistochemistry, we found that among the family of gap junction proteins, connexin (Cx) 26, Cx36, Cx37, Cx43, and Cx45 were expressed in the mouse neocortex. (ubc.ca)
  • GJA1 , also known as connexin43 (Cx43), is a member of the connexin family of proteins that is highly conserved among vertebrates. (biomedcentral.com)
  • generates two major cell-to-cell signals that are users of the acyl-homoserine lactone transmission family, operon codes for any putative coenzyme A ligase (seems to encode a response effector protein which itself is not involved in the biosynthesis of PQS. (columbiagypsy.net)
  • Thus, many questions regarding BMP9 signaling need to be answered: What are the type I and type II TGFbeta/BMP receptors involved in BMP9 binding? (uchicago.edu)
  • The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis . (wikipedia.org)
  • Eph receptors in turn compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). (readtiger.com)
  • SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. (antibody-antibodies.com)
  • Parathyroid hormone-related protein has been shown to interact with KPNB1 [9] [10] and Arrestin beta 1 . (wikipedia.org)
  • 2000 NFAT phosphorylation by protein kinases such as glycogen synthase kinase 3β (GSK3β) induces the nuclear export of NFAT avoiding its transactivation (Chow et al. (healthconnectionsvt.org)
  • p53 Signaling Phospho-Specific Array includes 196 highly specific and well-characterized phosphorylation antibodies in the p53 signaling pathway. (antibody-antibodies.com)
  • GPCR Signaling to MAPK_ERk Phospho-Specific Array includes 193 highly specific and well-characterized phosphorylation antibodies related to this signaling pathway. (antibody-antibodies.com)
  • IGF-1R Signaling Phospho-Specific Array includes 245 highly specific and well-characterized phosphorylation antibodies in the insulin-like growth factor 1 receptor signaling pathway. (antibody-antibodies.com)
  • Alvinella proteins seem to show a slow evolutionary rate and a higher similarity with proteins from Vertebrates compared to proteins from Arthropods or Nematodes. (biomedcentral.com)
  • Using both in vivo and in vitro approaches, we conducted a comparative analysis of CCN2-null and wildtype mice to study the roles of CCN2 and the other CCN proteins in cartilage development. (elsevier.com)
  • PURPOSES: Gap junction intercellular communication (GJIC) is essential for articular cartilage to respond appropriately to physical or biological stimuli and maintain homeostasis. (bvsalud.org)
  • It binds MATRILIN PROTEINS and is associated with development of cartilage and bone. (rush.edu)
  • Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage. (rush.edu)
  • CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. (wikipedia.org)
  • Regulation by heparan sulfate in fibroblast growth factor signaling. (ucdenver.edu)
  • A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. (viictr.org)
  • Hence, the regulation of WISP proteins could improve treatments for cancer patients. (biomedcentral.com)
  • This pool is enriched in glycoproteins that play a key role in intercellular communication, hormonal regulation and immunity. (biomedcentral.com)
  • These effects was only observed on protein levels indicating that a post transcriptional down regulation of VTG production is mediated by F in Arctic char. (diva-portal.org)
  • SRE Reporter Kit (MAPK_ERK Signaling Pathway ),The MAPK_ERK signaling pathway is a major participant in the regulation of cell growth and differentiation. (antibody-antibodies.com)
  • The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. (antibody-antibodies.com)
  • We are currently dissecting the functional roles of the important downstream mediators in BMP-induced osteogenic signaling. (uchicago.edu)
  • In our body, the gels of polysaccharides and fibrous proteins ( scleroproteins ) fill the interstitial space and act as a compression buffer against the stress placed on the Extracellular Matrix (ECM) . (wellnessadvocate.com)
  • The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g. (rtrn.net)
  • However, the ability of BMPs to induce osteoblast differentiation of mesenchymal stem cells has not been comprehensively investigated, mostly due to the fact that recombinant proteins are either not biologically active or not available for all BMPs. (uchicago.edu)
  • To investigate the effect of irradiated human lung fibroblasts (HLFs) on the canonical Wnt/β-catenin signaling pathway in human umbilical cord mesenchymal stem cells (HUMSCs). (bvsalud.org)
  • The exact mechanism by which AgRP inhibits melanocortin-receptor signalling is not completely clear. (wikidoc.org)
  • It may catalyse skeletal muscle hypertrophy , by inducing protein synthesis , and by blocking muscle atrophy . (ipfs.io)
  • In our body, the Extracellular Matrix (ECM) is the non-cellular component present within all tissues and organs, provides essential physical scaffolding that binds cells (as intercellular matrix ) and tissues together and initiates crucial biochemical and biophysical cues required for tissue morphogenesis, differentiation and homeostasis. (wellnessadvocate.com)
  • This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an increased number of myofibroblasts. (springer.com)
  • We are investigating the biological functions of BMPs and Wnt/beta-catenin signaling in regulating the osteoblast differentiation of MSCs. (uchicago.edu)
  • Our findings indicate that osteoblast differentiation is a well-regulated process in normal progenitor cells, while osteosarcoma cells are refractory to osteogenic differentiation signal. (uchicago.edu)
  • Critical mediators of BMP-induced differentiation of MSCs We have identified several potentially important signaling mediators of BMP-induced osteogenic differentiation. (uchicago.edu)
  • It is well documented that gap junctional intercellular communication is important in mediating normal cell growth, differentiation, and development. (springer.com)
  • Ovarian follicular development involves continual remodelling of the extracellular matrix (ECM) forming the basement membrane and intercellular framework that support granulosa cell (GC) growth and differentiation. (bioscientifica.com)
  • It was independently identified by two teams in 1997 based on its sequence similarity with agouti signalling peptide (ASIP), a protein synthesised in the skin that controls coat colour. (wikidoc.org)
  • The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin . (ipfs.io)
  • Angiogenesis of human peritoneal vascular endothelial cells (HPVECs), linked to vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) signaling, is a complication of peritoneal fibrosis (PF). (frontiersin.org)
  • In addition, C57BL/6 mice were repeatedly injected with exogenously formed AGE to establish whether AGE modulate retinal CCN growth factors in vivo. (nih.gov)
  • Huang J, Zhao L, Chen D. Growth factor signalling in osteoarthritis. (rush.edu)
  • Eph/ephrin signaling controls the guidance of neuronal axons through their ability to inhibit the survival of axonal growth cones , which repels the migrating axon away from the site of Eph/ephrin activation. (readtiger.com)
  • Secretion of endothelin-1 (ET-1)1 from the endothelium signals vasoconstriction and influences local cellular growth and survival. (readtiger.com)
  • Translationally controlled tumor protein (TCTP) is a conserved protein involved in growth control, but its role in cell junctions is unknown. (bvsalud.org)
  • Here we show that Drosophila Tctp directly interacts with the septate junction protein Coracle (Cora) to regulate epithelial integrity and organ growth. (bvsalud.org)
  • Differences observed between asthmatic and non-asthmatic bronchial fibroblasts (e.g., response to transforming growth factor β, cell shape, elasticity, and protein expression profile) may have a crucial influence on this phenomenon. (springer.com)
  • Approximately, 10 % of patients with colorectal cancer (CRC) express BRAF , which may be actionable with selective BRAF inhibitors or in combination with inhibitors of complementary signaling axes. (bireme.br)
  • Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons. (harvard.edu)
  • To monitor newborn neurons, we introduced a plasmid containing green fluorescent protein driven by a neuronal (Tα1 tubulin) promoter into the embryonic neocortex using in utero electroporation. (ubc.ca)
  • Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. (biomedcentral.com)
  • Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins . (wikipedia.org)
  • Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. (biomedcentral.com)
  • T. gondii disrupted vascular endothelial cadherin (VE-cadherin) and β-catenin localization to the cell periphery and reduced VE-cadherin protein expression. (asm.org)
  • Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3. (viictr.org)
  • Blockade of α4 integrin/CD49d attenuated the diabetes-induced upregulation of NF-κB activation, VEGF, and TNF-α protein levels and reduced significantly diabetes-induced leukocyte adhesion and vascular leakage. (arvojournals.org)
  • Western blot analysis was done to detect the expression of Cx43 and PI3K/Akt signalling. (bvsalud.org)