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CCN Intercellular Signaling ProteinsNephroblastoma Overexpressed ProteinCysteine-Rich Protein 61Connective Tissue Growth FactorImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsIntegrin alpha6beta1Fibromatosis, GingivalIntegrin alpha5beta1Integrin alphaVbeta3Cell AdhesionConnective Tissue CellsTransforming Growth Factor betaFibrosisFibroblastsInsulin-Like Growth Factor Binding ProteinsSignal TransductionCell MovementGrowth and DevelopmentEar CartilageMurinaeMesangial CellsGene Expression RegulationCells, CulturedNeovascularization, PhysiologicSmad3 ProteinCell ProliferationChondrocytesBibliometricsPublicationsResearchBiomedical ResearchPublishingPubMedAcademies and InstitutesParathyroid Hormone-Related ProteinTooth EruptionReceptor, Parathyroid Hormone, Type 1Parathyroid HormoneReceptors, Parathyroid HormoneMammary Glands, AnimalEncyclopedias as TopicBinding, CompetitiveInterferometryFluorescence PolarizationProtein BindingBinding SitesKineticsRadioligand AssayCopyrightProtein Structure, Tertiary
CCN Intercellular Signaling Proteins: A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.Nephroblastoma Overexpressed Protein: A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.Cysteine-Rich Protein 61: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.Connective Tissue Growth Factor: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Integrin alpha6beta1: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.Fibromatosis, Gingival: Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)Integrin alpha5beta1: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.Integrin alphaVbeta3: An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).Cell Adhesion: Adherence of cells to surfaces or to other cells.Connective Tissue Cells: A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Insulin-Like Growth Factor Binding Proteins: A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Growth and Development: The series of changes to the shape, size, components, and functions of an individual organism that occur over time as the organism progresses from its initial form to full size and maturity.Ear Cartilage: Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.Murinae: A subfamily in the family MURIDAE, comprising the Old World MICE and RATS.Mesangial Cells: Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Smad3 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Chondrocytes: Polymorphic cells that form cartilage.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Parathyroid Hormone-Related Protein: A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.Tooth Eruption: The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)Receptor, Parathyroid Hormone, Type 1: A parathyroid hormone receptor subtype that recognizes both PARATHYROID HORMONE and PARATHYROID HORMONE-RELATED PROTEIN. It is a G-protein-coupled receptor that is expressed at high levels in BONE and in KIDNEY.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Receptors, Parathyroid Hormone: Cell surface proteins that bind PARATHYROID HORMONE with high affinity and trigger intracellular changes which influence the behavior of cells. Parathyroid hormone receptors on BONE; KIDNEY; and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis.Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Interferometry: Measurement of distances or movements by means of the phenomena caused by the interference of two rays of light (optical interferometry) or of sound (acoustic interferometry).Fluorescence Polarization: Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Kinetics: The rate dynamics in chemical or physical systems.Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (1/98)

We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from primary human osteoblast cells encoding a 250-amino acid single chain polypeptide. Murine CTGF-L cDNA, encoding a polypeptide of 251 amino acids, was obtained from a murine lung cDNA library. CTGF-L protein bears significant identity ( approximately 60%) to the CCN (CTGF, Cef10/Cyr61, Nov) family of proteins. CTGF-L is composed of three distinct domains, an insulin-like growth factor binding domain, a von Willebrand Factor type C motif, and a thrombospondin type I repeat. However, unlike CTGF, CTGF-L lacks the C-terminal domain implicated in dimerization and heparin binding. CTGF-L mRNA ( approximately 1.3 kilobases) is expressed in primary human osteoblasts, fibroblasts, ovary, testes, and heart, and a approximately 26-kDa protein is secreted from primary human osteoblasts and fibroblasts. In situ hybridization indicates high expression in osteoblasts forming bone, discrete alkaline phosphatase positive bone marrow cells, and chondrocytes. Specific binding of 125I-labeled insulin-like growth factors to CTGF-L was demonstrated by ligand Western blotting and cross-linking experiments. Recombinant human CTGF-L promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, recombinant human CTGF-L inhibits osteocalcin production in rat osteoblast-like Ros 17/2.8 cells. Taken together, these results suggest that CTGF-L may play an important role in modulating bone turnover.  (+info)

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. (2/98)

Inflammatory breast cancer is a rapidly growing, distinct form of locally advanced breast cancer that carries a guarded prognosis. To identify the genes that contribute to this aggressive phenotype, we compared under- and overexpressed sequences in an inflammatory breast tumor cell line with those of actively replicating normal human mammary epithelial cell lines using differential display. Of the 17 transcripts isolated and characterized from these experiments, overexpression of RhoC GTPase and loss of expression of a novel gene on 6q22, LIBC (lost in inflammatory breast cancer), were highly correlated (P<0.0095 and P<0.0013, respectively) with the inflammatory phenotype when a panel of archival inflammatory breast cancers was compared with noninflammatory stage III breast cancers by in situ hybridization. This study suggests two new molecular markers specific for inflammatory breast cancer.  (+info)

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. (3/98)

WISP-1 (Wnt-1 induced secreted protein 1) is a member of the CCN family of growth factors. This study identifies WISP-1 as a beta-catenin-regulated gene that can contribute to tumorigenesis. The promoter of WISP-1 was cloned and shown to be activated by both Wnt-1 and beta-catenin expression. TCF/LEF sites played a minor role, whereas the CREB site played an important role in this transcriptional activation. WISP-1 demonstrated oncogenic activities; overexpression of WISP-1 in normal rat kidney fibroblast cells (NRK-49F) induced morphological transformation, accelerated cell growth, and enhanced saturation density. Although these cells did not acquire anchorage-independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1.  (+info)

N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (4/98)

Hereditary motor and sensory neuropathies, to which Charcot-Marie-Tooth (CMT) disease belongs, are a common cause of disability in adulthood. Growing awareness that axonal loss, rather than demyelination per se, is responsible for the neurological deficit in demyelinating CMT disease has focused research on the mechanisms of early development, cell differentiation, and cell-cell interactions in the peripheral nervous system. Autosomal recessive peripheral neuropathies are relatively rare but are clinically more severe than autosomal dominant forms of CMT, and understanding their molecular basis may provide a new perspective on these mechanisms. Here we report the identification of the gene responsible for hereditary motor and sensory neuropathy-Lom (HMSNL). HMSNL shows features of Schwann-cell dysfunction and a concomitant early axonal involvement, suggesting that impaired axon-glia interactions play a major role in its pathogenesis. The gene was previously mapped to 8q24.3, where conserved disease haplotypes suggested genetic homogeneity and a single founder mutation. We have reduced the HMSNL interval to 200 kb and have characterized it by means of large-scale genomic sequencing. Sequence analysis of two genes located in the critical region identified the founder HMSNL mutation: a premature-termination codon at position 148 of the N-myc downstream-regulated gene 1 (NDRG1). NDRG1 is ubiquitously expressed and has been proposed to play a role in growth arrest and cell differentiation, possibly as a signaling protein shuttling between the cytoplasm and the nucleus. We have studied expression in peripheral nerve and have detected particularly high levels in the Schwann cell. Taken together, these findings point to NDRG1 having a role in the peripheral nervous system, possibly in the Schwann-cell signaling necessary for axonal survival.  (+info)

A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (5/98)

Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, nephroblastoma overexpressed) encode cysteine-rich secreted proteins with roles in human fibrotic disorders and cancer progression. Using targeted differential displays, we identified a novel variant of the CCN family member WISP1 (Wnt-induced secreted protein 1), named WISP1v, as overexpressed in scirrhous gastric carcinomas. Predicted protein of the WISP1v completely lacks a module of Von Willebrand type C that is thought to participate in protein complex formation. Ectopic expression revealed WISP1v to be a secreted oncoprotein inducing a striking cellular transformation and rapid piling-up growth. It is noteworthy that WISP1v transfectants enhanced the invasive phenotype of co-cultured gastric carcinoma cells, while wild-type WISP1 had no such potential. These findings suggest that CCN protein WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma.  (+info)

WISP-1 binds to decorin and biglycan. (6/98)

Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Structural and experimental evidence suggests that CCN family member activities are modulated by their interaction with sulfated glycoconjugates. To elucidate the mechanism of action for WISP-1, we characterized the specificity of its tissue and cellular interaction and identified binding factors. WISP-1 binding was restricted to the stroma of colon tumors and to cells with a fibroblastic phenotype. By using a solid phase assay, we showed that human skin fibroblast conditioned media contained WISP-1 binding factors. Competitive inhibition with different glycosaminoglycans and treatment with glycosaminoglycan lyases and proteases demonstrated that binding to the conditioned media was mediated by dermatan sulfate proteoglycans. Mass spectrometric analysis identified the isolated binding factors as decorin and biglycan. Decorin and biglycan interacted directly with WISP-1 and inhibited its binding to components in the conditioned media. Similarly, WISP-1 interaction with human skin fibroblasts was inhibited by dermatan sulfate, decorin, and biglycan or by treatment of the cell surface with dermatan sulfate-specific lyases. Together these results demonstrate that decorin and biglycan are WISP-1 binding factors that can mediate and modulate its interaction with the surface of fibroblasts. We propose that this specific interaction plays a role in the regulation of WISP-1 function.  (+info)

COL11A1 in FAP polyps and in sporadic colorectal tumors. (7/98)

BACKGROUND: We previously reported that the alpha-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin. METHODS: We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/beta-catenin pathway. RESULTS: In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/beta-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas. CONCLUSIONS: Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/beta-catenin pathway in FAP and sporadic colorectal cancer.  (+info)

Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. (8/98)

To gain insight into the role of the CCN genes in human breast carcinomas, we quantified connective tissue growth factor (CTGF), WISP-1, CYR61, and human NOV (NOVH) mRNA expression levels in samples from 44 primary breast tumors and seven normal breasts using quantitative real-time PCR assay. Overexpression of CTGF, WISP-1, CYR61, and NOVH was found in 55 (24 of 44), 46 (20 of 44), 39 (17 of 44), and 11% (5 of 44) primary breast tumors, respectively. Statistical univariate analysis was performed to explore the links between expression of the CCN genes and clinical and pathological parameters. Interestingly, significant associations were found between CTGF expression versus stage, tumor size, lymph node status, and age at diagnosis; WISP-1 mRNA levels versus stage, tumor size, lymph node, and HER-2/neu overexpression; and CYR61 expression with stage, tumor size, lymph node, age, and estrogen receptor expression. In contrast to CTGF, WISP-1, and CYR61, no significant correlation was found between NOVH expression and any of the clinical and pathological factors. Furthermore, multivariate classification tree model analysis showed that stage and lymph node involvement were important for predicting CTGF expression in breast cancers; the stage, age, and HER-2/neu status were key factors for WISP-1 expression; and the stage, age, and estrogen receptor were valuable predictors for CYR61 expression. In summary, these results suggest that CTGF, WISP-1, and CYR61 may play a role in the progression of breast cancer and might serve as a valuable tool for monitoring tumor status of breast cancer patients.  (+info)

Whole Exome Screening Identifies Novel and Recurrent WISP3 Mutations Causing Progressive Pseudorheumatoid Dysplasia in Jammu...Whole Exome Screening Identifies Novel and Recurrent WISP3 Mutations Causing Progressive Pseudorheumatoid Dysplasia in Jammu...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Arthropathy, progressive pseudorheumatoid, of childhood Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comArthropathy, progressive pseudorheumatoid, of childhood Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Arthropathy, progressive pseudorheumatoid, of childhood information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
The CCN family of proteins: structure-function relationships | Semantic ScholarThe CCN family of proteins: structure-function relationships | Semantic Scholar
The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How these proteins influence such a range of functions remains incompletely understood but is probably related to their discrete modular nature and a complex array of intra- and inter-molecular interactions with a variety of regulatory proteins and ligands. Although certain aspects of their biology can be attributed to the four individual modules that constitute the CCN proteins, recent results suggest that some of their biological functions require cooperation between modules. Indeed, the modular structure of CCN proteins provides important insight into their structure-function relationships.
CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin 1/focal adhesion kinase...CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin 1/focal adhesion kinase...
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized by the proliferation of fibroblasts and increased deposition of the extracellular matrix. The CCN6/WISP-3 is a member of the CCN family of matricellular proteins, which consists of six members that are involved in many vital biological functions. However, the regulation of lung fibroblasts mediated by CCN6 protein has not been fully elucidated. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin β1, leading to the phosphorylation of FAKY397. Furthermore, CCN6 showed a weak, but significant, ability to stimulate the expression of fibronectin. CCN6 was highly expressed in the lung tissues of mice treated with bleomycin. Our results suggest that CCN6 plays a role in the fibrogenesis of the lungs mainly by stimulating the growth of lung fibroblasts and is a potential target for the treatment of pulmonary fibrosis ...
Ccn2 - CCN family member 2 precursor - Mus musculus (Mouse) - Ccn2 gene & proteinCcn2 - CCN family member 2 precursor - Mus musculus (Mouse) - Ccn2 gene & protein
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
Abstract 332: Circulating CCN1 Promotes Angiogenesis via Interaction with Blood CD34+ Cells | CirculationAbstract 332: Circulating CCN1 Promotes Angiogenesis via Interaction with Blood CD34+ Cells | Circulation
Introduction: CCN1 is so far known as a protein of the extracellular matrix mediating proliferation, adhesion, migration and angiogenesis in an integrin-dependent manner. We recently reported that CCN1 is up-regulated under pathophysiological conditions in the cardiovascular system. Since blood CD34+ progenitor cells have been shown to promote tissue regeneration, we investigated if CCN1 induces angiogenesis by stimulating blood CD34+ cells.. Methods and Results: Circulating CCN1 was detected for the first time in human serum samples (Western blot). Rekombinant CCN1 (100 ng/mL) and supernatants from CCN1-stimulated human CD34+ progenitor cells promoted tube-formation (Matrigel-Assay; P , 0.05; n = 4) and proliferation of endothelial cells (BrdU-incorporation; P , 0.05; n = 4). Moreover, CCN1 significantly induced angiogenesis in the context of blood CD34+ cells in vivo determined in Matrigel implanted into C57/BL6 mice as measured by the hemoglobin content (Drabkins reagent) and by CD31 ...
Protocols for screening for binding partners of CCN proteins: Yeast two-hybrid system - Fingerprint - Okayama UniversityProtocols for screening for binding partners of CCN proteins: Yeast two-hybrid system - Fingerprint - Okayama University
Fingerprint Dive into the research topics of Protocols for screening for binding partners of CCN proteins: Yeast two-hybrid system. Together they form a unique fingerprint. ...
Eye - Pseudorheumatoid nodules of eyelidEye - Pseudorheumatoid nodules of eyelid
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Inhibition of Delta pH pathway protein transport by ant | Open-iInhibition of Delta pH pathway protein transport by ant | Open-i
Inhibition of Delta pH pathway protein transport by antibodies to Hcf106. (A) Maize thylakoids were preincubated with 0.1 mg/ml anti-Hcf106 or preimmune (PI) Ig
Cyr61/CCN1 Products: R&D SystemsCyr61/CCN1 Products: R&D Systems
View our 12 Cyr61/CCN1 products for your research including Cyr61/CCN1 Primary Antibodies, ELISAs, Proteome Profiler Antibody Arrays, Proteins and Enzymes, and Simple Plex Assays.
CYR61/CCN1 Antibody 26689-1-AP | ProteintechCYR61/CCN1 Antibody 26689-1-AP | Proteintech
CYR61/CCN1 Antibody 26689-1-AP has been identified with ELISA, WB, IF. 26689-1-AP detected 42 kDa band in A431 cells with 1:500-1:3000 dilution...
P53 Pathway Proteins - Creative BiomartP53 Pathway Proteins - Creative Biomart
The p53 pathway is composed of genes and their products that are targeted to respond to stress signals. More than seven negative and three positive feedback loops in the p53 pathway have identified.
重组人CCN1蛋白(ab50074)|Abcam中国重组人CCN1蛋白(ab50074)|Abcam中国
购买我们的重组人CCN1蛋白。Ab50074为蛋白片段，在大肠杆菌中生产并经过SDS-PAGE, Functional Studies实验验证。Abcam提供免费的实验方案，操作技巧及专业的支持。
Identification of rCop-1, a New Member of the CCN Protein Family, as a Negative Regulator for Cell Transformation | Molecular...Identification of rCop-1, a New Member of the CCN Protein Family, as a Negative Regulator for Cell Transformation | Molecular...
Here we describe the isolation and characterization of rCop-1, a novel CCN family protein whose expression was completely lost after cell transformation. Functional studies suggest that rCop-1is a negative regulator for cell transformation based on the following findings. The loss of rCop-1 expression correlates extremely well with cell transformation in culture, since cells transformed by a variety of mechanisms all lost rCop-1 expression. BALB/c A31 and Rat-1 are both immortalized but nontransformed, yet only the former expresses rCop-1. However, both A31 and REFs, the parental cells of Rat-1, lose rCop-1 expression when transformed by a variety of means. This suggests that the loss of rCop-1expression in cultured rodent fibroblasts may not be necessary for cell immortalization but may be so for cell transformation. Efficient retroviral gene transfer of rCop-1 exhibited a dramatic cytotoxic effect on the transformed cells but had little effect on the nontransformed cells.. The first member of ...
Fettsyror, rasvahapot: Uusi väitöskirja joka pureutuu lihavuuden ja diabeteksen perussyihin adipogeneesin tasolta. WISP2 ...Fettsyror, rasvahapot: Uusi väitöskirja joka pureutuu lihavuuden ja diabeteksen perussyihin adipogeneesin tasolta. WISP2 "...
WNT1-inducible-signaling pathway protein 2 (WISP2) is primarily expressed in mesenchymal stem cells, fibroblasts, and adipogenic precursor cells. It is both a secreted and cytosolic protein, the latter regulating precursor cell adipogenic commitment and PPARγ induction by BMP4. To examine the effect of the secreted protein, we expressed a full-length and a truncated, non-secreted WISP2 in NIH3T3 fibroblasts. Secreted, but not truncated WISP2 activated the canonical WNT pathway with increased β-catenin levels, its nuclear targeting phosphorylation, and LRP5/6 phosphorylation. It also inhibited Pparg activation and the effect of secreted WISP2 was reversed by the WNT antagonist DICKKOPF-1. Differentiated 3T3-L1 adipose cells were also target cells where extracellular WISP2 activated the canonical WNT pathway, inhibited Pparg and associated adipose genes and, similar to WNT3a, promoted partial dedifferentiation of the cells and the induction of a myofibroblast phenotype with activation of markers ...
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BMP4 promotes commitment and adipogenic differentiation of precursor cells, whereas canonical WNT activation is inhibitory to both these processes. To make progress in understanding adipogenesis, we need to understand the apparent crosstalk between these pathways.. We recently identified a secreted and WNT-inducible protein, WISP2, as a novel adipokine providing new insight into the crosstalk between WNT and BMP4 signaling (53). WISP2, a member of the CCN family, has previously been found to crosstalk with transforming growth factor-β and to prevent epithelial mesenchymal transformation in cancer cells (54). It is a secreted protein, highly expressed in mesenchymal stem cells and preadipocytes (53). However, it is also present in the cytosol in undifferentiated cells as well as in the nucleus, although mechanisms regulating the subcellular distribution are not known. WISP2 expression is considerably higher in the subcutaneous adipose tissue than in visceral fat, and the expression is positively ...
Jennifer L. Young, Ph.D. - University of Rochester Medical CenterJennifer L. Young, Ph.D. - University of Rochester Medical Center
My research focuses on elucidating the mechanism(s) of cell death and survival of primary alveolar epithelial cells and lung fibroblasts in response to the extracellular matrix associated signaling molecule, CCN1/Cyr61. CCN1/Cyr61 is an extracellular matrix (ECM)-associated signaling molecule that functions to promote cell adhesion, migration, survival and differentiation in the context of vascular development. Most recently we have shown that CCN1/Cyr61 can also modulate cell death in certain cells and can promote cell death in response to TNFa. In the context of the lung, I have found that CCN1/Cyr61 together with TNFa causes apoptosis of alveolar epithelial cells and lung fibroblasts. Because CCN1/Cyr61 has been shown to be induced in the lungs of patients with COPD and ARDS, I hypothesize that CCN1/Cyr61, together with inflammatory mediators such as TNFa causes cell death of primary lung cells in vivo, thus contributing to lung injury. I have also found that CCN1/Cyr61 functional knock-out ...
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CCN1 has been shown to promote DNA synthesis and proliferation of various cell types, including prostate epithelial and stromal cells (19). Thus, it is not surprising that endogenous expression of CCN1 elevates cell proliferation in PC-3 and DU-145 cells (Fig. 2). Whereas CCN1 supports endothelial cell survival through interaction with integrin αvβ3, it can also induce apoptosis in some cell types, including fibroblasts, through an α6β1-HSPG-dependent pathway (24, 25). Although CCN1 does not induce cell death in prostatic cells on its own, it cooperates with TRAIL to trigger apoptosis through interaction with integrins αvβ3 and α6β4 and syndecan-4 (Fig. 5). The ability of CCN1 to promote TRAIL-induced cell death in both p53-null (PC-3) and p53 mutant (DU-145) cells indicates that it functions through a p53-independent pathway and suggests that it may be involved in apoptosis of other cancer cells, many of which have lost p53 expression or function. The requirement of multiple CCN1 ...
anti-CCN3 antibody | GeneTexanti-CCN3 antibody | GeneTex
CCN3 antibody (nephroblastoma overexpressed gene) for ICC/IF, IHC-P, WB. Anti-CCN3 pAb (GTX103377) is tested in Human, Mouse samples. 100% Ab-Assurance.
Expression of WISP2 in cancer - Summary - The Human Protein AtlasExpression of WISP2 in cancer - Summary - The Human Protein Atlas
Expression of WISP2 (CCN5, CT58, CTGF-L) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Cyr61/CCN1 Antibody (NB100-356): Novus BiologicalsCyr61/CCN1 Antibody (NB100-356): Novus Biologicals
Rabbit Polyclonal Anti-Cyr61/CCN1 Antibody. Validated: WB, Simple Western, B/N, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Rabbit. 100% Guaranteed.
Recombinant Human CCN1 protein (Fc Chimera) (ab191971)Recombinant Human CCN1 protein (Fc Chimera) (ab191971)
Buy our Recombinant Human CCN1 protein (Fc Chimera). Ab191971 is a full length protein produced in HEK 293 cells and has been validated in SDS-PAGE, HPLC…
Clinic | CCN GroupClinic | CCN Group
CCN Klinik conducts medical equipment planning, investment and operation activities in state-of-the-art health campuses operated with PPP model ...
These findings suggest that CCN2 doesnot impact PDGF | Cannabinoid receptor-cannabinoid-receptor.comThese findings suggest that CCN2 doesnot impact PDGF | Cannabinoid receptor-cannabinoid-receptor.com
CCN2 potentiates PDGF signaling in vascular cellsPDGF-B, created by endothelial cells, and its receptor,PDGFRb expressed in pericytes, are required for
The Chemistry Development Kit / Mailing ListsThe Chemistry Development Kit / Mailing Lists
On Oct 4, 2007, at 2:46 PM, Rajarshi Guha wrote: , Hi, Ive found an error in a recursive smarts for a nitrogen in a , basic amine , , The following SMARTS [NX3;H2,H1;!$(NC=O)] gives 3 hits , for CC1CCCC(C1)N1CCN(CC1)C1CCN(CC1)Cc1ccccc1 whereas it should be 0 Given that in the above structure, the Ns are tertiary, they have no explicit or implicit hydrogens. As a result if I change the SMARTS to [NX3;h2,h1;!$(NC=O)] this works. But the daylight depict match page returns 0 hits for both [NX3;H2,H1;!$(NC=O)] and [NX3;h2,h1;!$(NC=O)] However for c1nc2=NC3=C(C(n2[nH]1)c1cc(cc(c1)F)F)C(=O)CC(C3)c1ccco1 where one of the Ns does have an explicit H, the Daylight page returns a single hit for both forms of the SMARTS The CDK returns 2 hits for the explicit H SMARTS and the correct, single, hit for the implicit H form of the SMARTS. I dont see how it can get 2 hits for the explicit SMARTS form ------------------------------------------------------------------- Rajarshi Guha ,[email protected], GPG Fingerprint: ...
Expression of CCN Family Proteins in Epiretinal and Vitreoretinal Membranes | IOVS | ARVO JournalsExpression of CCN Family Proteins in Epiretinal and Vitreoretinal Membranes | IOVS | ARVO Journals
Purpose: : Proliferative vitreoretinopathy (PVR) is a well known complication of ocular trauma and rhegmatogenous retinal detachment leading to progressive deterioration of vision and potential blindness. Although several cell types and cytokines have been detected in PVR membranes their definite pathogenic mechanisms are still unknown. Members of the CCN family of matricellular proteins are multifunctional growth factors representing a novel class of extracellular matrix-associated signalling molecules. Several studies demonstrated that members of the CCN family are involved in the control of cell adhesion, chemotaxis, cell migration and cell proliferation. In particular, it was demonstrated that CTGF, CYR61 and NOV possess fibrotic and angiogenic activity being involved in wound healing and several fibrotic diseases. The aim of the present study was to investigate whether CCN proteins are expressed and increased in epiretinal membranes to shed more light on the pathogenesis of PVR Methods: : ...
WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast...WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast...
TY - JOUR. T1 - WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast proliferation but inhibits TNF-α-induced cardiomyocyte death. AU - Venkatachalam, Kaliyamurthi. AU - Venkatesan, Balachander. AU - Valente, Anthony J.. AU - Melby, Peter. AU - Nandish, Sailesh. AU - Reusch, Jane E B. AU - Clark, Robert A.. AU - Chandrasekar, Bysani. PY - 2009/5/22. Y1 - 2009/5/22. N2 - WNT1-inducible signaling pathway protein-1 (WISP1), a member of the CYR61/CTGF/Nov family of growth factors, can mediate cell growth, transformation, and survival. Previously we demonstrated that WISP1 is up-regulated in post-infarct heart, stimulates cardiac fibroblast proliferation, and is induced by the proinflammatory cytokine tumor necrosis factor-α (TNF-α). Here we investigated (i) the localization of TNF-α and WISP1 in post-infarct heart, (ii) the mechanism of TNF-α-mediated WISP1 induction in primary human cardiac fibroblasts (CF), (iii) the role of ...
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine...Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine...
The CCN2 protein is thought to consist of four separate modules. Module 1 is identical to insulin-like growth factor binding protein, module 2 consists of a chordin-like cysteine-rich domain, module 3 is composed of a thrombospondin type 1 domain and module 4 is designated as the CT module or cysteine knot. Modules 1 and 2 make up the N-terminal domain and are linked by a hinge region to the C-terminal domain which is made up of modules 3 and 4 [31, 32]. The ELISA analysis used in our study detects C-terminal CCN2 which translates into detection of both C-terminal fragments and whole CCN2. Our analysis is not able to detect N-terminal CCN2 fragments. Other studies have evaluated the utility of N-terminal CCN2 as a marker of intraocular fibrosis and in scleroderma. In these studies, neither C-terminal nor whole CCN2 were elevated in disease. As as result, it has been postulated that during a fibrotic response, in vivo CCN2 is cleaved resulting in N-terminal fragments which are excreted into the ...
CYR61 - WikipediaCYR61 - Wikipedia
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers. CYR61 was first identified as a protein encoded by a ...
Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes<...Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes<...
TY - JOUR. T1 - Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes. AU - Nishida, Takashi. AU - Kubota, Satoshi. AU - Aoyama, Eriko. AU - Janune, Danilo. AU - Maeda, Azusa. AU - Takigawa, Masaharu. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2011/11. Y1 - 2011/11. N2 - CCN2 (also known as connective tissue growth factor) interacts with several growth factors involved in endochondral ossification via its characteristic four modules and modifies the effect of such growth factors. Presently we investigated whether CCN2 interacts with fibroblast growth factor 2 (FGF2). Solid-phase binding assay, immunoprecipitation-Western blot analysis, and surface plasmon resonance (SPR) spectroscopy revealed that the C-terminal module of CCN2 (CT) directly bound to FGF2 with a dissociation constant of 5.5 nM. Next, we examined the combinational effects of CCN2 and FGF2 on the proliferation of and matrix metalloproteinase (MMP)-9 and -13 ...
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-betaConnective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) prot …
Lester LauLester Lau
The extracellular matrix plays critical roles in regulating diverse biological and pathological processes, including developmental morphogenesis, tissue repair and remodeling, inflammation and host defense, and progression of diseases such as cancer. Our laboratory is interested in the biological functions of CCNs, a family of cysteine-rich, dynamically expressed matricellular proteins that regulates a broad range of cellular activities through direct binding to integrin receptors and heparan sulfate proteoglycans. Ccn1- and Ccn2-null mice are embryonic and perinatal lethal due to cardiovascular and skeletal defects, respectively, underscoring the importance of these matrix proteins. In addition, aberrant expression of Ccn1 and Ccn2 is associated with pathological conditions including wound healing, atherosclerosis, restenosis, rheumatoid arthritis, and cancer.. Our current studies aim to understand how CCN proteins function through integrin-mediated signaling to regulate diverse processes, ...
Expression of WISP2 in carcinoid - The Human Protein AtlasExpression of WISP2 in carcinoid - The Human Protein Atlas
Expression of WISP2 (CCN5, CT58, CTGF-L) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Cyr61/CCN1 Antibody [Biotin] (NB100-356B): Novus BiologicalsCyr61/CCN1 Antibody [Biotin] (NB100-356B): Novus Biologicals
Rabbit Polyclonal Anti-Cyr61/CCN1 Antibody [Biotin]. Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Rabbit. 100% Guaranteed.
Respironics Wisp nasal mask | Apnea BoardRespironics Wisp nasal mask | Apnea Board
(04-09-2013, 02:45 PM)grumpycat Wrote: So, I received my Wisp on 3/22 with silicone nose mask. Very satisfied with it, except that I find that if you move around (from supine to side) the mask shifts
PeptidePeptide
Smiles: CCC3NC(=O)C(NC(=O)c1ncccc1(O))C(C)OC(=O)C(NC(=O)C5CC(=O)CCN5(C(=O)C(Cc2ccc(cc2)N(C)C)N(C)C(=O)C4CCCN4(C3(=O))))c6ccccc6 ...
Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein...Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein...
LRP1 is known to be a receptor for signal transmission and endocytosis. We formerly reported that LRP1 regulates WNT/β-catenin and protein kinase C signaling in chondrocytes and represses the hypertrophy of chondrocytes during endochondral ossification, and that LRP1 is co-localized with a ligand, CCN2, which conducts endochondral ossification, on chondrocytes. However, the role of LRP1 in endocytotic transport of CCN2 in chondrocytes is not yet understood. In the present study, we investigated the interaction between LRP1 and CCN2 during endocytotic trafficking.. RNAi-mediated knockdown of LRP1 in chondrocytic HCS-2/8 cells showed that the amount of exogenous CCN2 binding/incorporation was decreased in the LRP1 down-regulated cells. Importantly, we observed that CCN2 internalization in chondrocytes was dependent on clathrin and internalizated CCN2 was co-localized with an early or recycling endosome marker. Transcytosis of CCN2 through HCS-2/8 cells was confirmed by performing experiments with ...
How CCN WorksHow CCN Works
CCN benefits patients and family members by providing information, resources and facts on adult cardiac care and access to cardiac care treatment centres throughout the province.. In addition to helping to plan, coordinate, implement and evaluate cardiovascular care in Ontario, CCN is responsible for developing, maintaining and reporting on the provincial cardiac wait list registry for all patients waiting for selected adult advanced cardiac procedures.. In the role of monitoring and enhancing the quality, equity and access of cardiac services in Ontario, CCN develops strategies, based on best practices, to better manage cardiovascular disease across the continuum of care, including strategies to prevent acute hospital readmissions, decrease demand on emergency departments and decrease the need for initial and repeat procedures.. ...
WISP - Wheat Improvement Strategic Programme - The University of NottinghamWISP - Wheat Improvement Strategic Programme - The University of Nottingham
Wheat is related to a large number of other species many of which are wild and uncultivated. These wild relatives, unlike wheat, provide a vast and largely untapped reservoir of genetic variation for potentially most, if not all, agronomically important traits, which can be used in the development of new higher yielding varieties, adapted to the changing environment.. The primary objective of the Nottingham/BBSRC Wheat Research Centre (WRC) at Sutton Bonington is to transfer genetic variation for agronomically and scientifically important traits from wild and distantly related species into wheat and to distribute the germplasm generated world wide for exploitation in breeding programmes and in scientific research. The WRCs research, which is part of the WISP Programme, is underpinned by funding from the BBSRC and Nottingham University in addition to a range of other funders from both the public and private sectors. Key collaborators include JIC, the University of Bristol, Rothamsted Research, ...
nephroblastoma | Britannica.comnephroblastoma | Britannica.com
nephroblastoma: Malignant renal (kidney) tumour of early childhood. In 75 percent of the cases, the tumour grows before the age of five; about two-thirds of the instances are apparent by two years...
KAKEN - Researchers | INOUE Tsutomu (30406475)KAKEN - Researchers | INOUE Tsutomu (30406475)
Affiliation：埼玉医科大学,医学部,准教授, Research Field：Kidney internal medicine,Radiation science,Urology, Keywords：腎線維化,CCN2,線維化,慢性腎臓病,尿細管上皮細胞,遺伝子改変動物,線維芽細胞,CKD,急性腎障害(AKI),転移性腎癌, # of Research Projects：6, # of Research Products：18, Ongoing Project：CCN2機能制御による慢性腎臓病の新規治療法の開発
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Wormmon He emerges right after me, materializing in light from the soles of his boots to the last wisp of his dark onyx hair. He’s clad in black, now-- po...
Unusual Facts About Newborns | POPSUGAR FamilyUnusual Facts About Newborns | POPSUGAR Family
Most moms-to-be fill their heads with visions of delivering a perfect little bundle of joy with rosy cheeks, flawless skin, and sweet wisps of hair. The
ACP - Abstract - CCN activity and droplet growth kinetics of fresh and aged monoterpene secondary organic aerosolACP - Abstract - CCN activity and droplet growth kinetics of fresh and aged monoterpene secondary organic aerosol
Abstract. The ability of secondary organic aerosol (SOA) produced from the ozonolysis of α-pinene and monoterpene mixtures (α-pinene, β-pinene, limonene and 3-carene) to become cloud droplets was investigated. A static CCN counter and a Scanning Mobility CCN Analyser (a Scanning Mobility Particle Sizer coupled with a Continuous Flow counter) were used for the CCN measurements. Consistent with previous studies monoterpene SOA is quite active and would likely be a good source of cloud condensation nuclei (CCN) in the atmosphere. A decrease in CCN activation diameter for α-pinene SOA of approximately 3 nm hr−1 was observed as the aerosol continued to react with oxidants. Hydroxyl radicals further oxidize the SOA particles thereby enhancing the particle CCN activity with time. The initial concentrations of ozone and monoterpene precursor (for concentrations lower than 40 ppb) do not appear to affect the activity of the resulting SOA. Köhler Theory Analysis (KTA) is used to infer the molar ...
Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin...Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin...
Stromal mediators play a fundamental role in promoting mammary differentiation, and the contact between mammary epithelial cells and components of the basement membrane contributes to the prolactin-induced transcription of milk proteins [47]. Using the Tet-off system for inducible CTGF/CCN2 expression in the HC11 mouse mammary epithelial cell background, CTGF/CCN2 not only enhanced the early transcription of β-casein in response to lactogenic hormone, but also contributed to the formation of mammospheres, a hallmark of terminal differentiation in these cells. In addition, exogenous CTGF/CCN2 enhanced the formation of differentiated MCF10A acini in three dimensional cultures, extending the role of CTGF/CCN2 to another culture system which is likely to be structurally and physiologically relevant to the in vivo setting [42]. The role of CTGF/CCN2 in lactogenic differentiation may depend on its function in the expression and stabilization of matrix-integrin complexes, an activity which promotes ...
Inflammatory Breast Cancer | Tampa General HospitalInflammatory Breast Cancer | Tampa General Hospital
Inflammatory Breast Cancer Inflammatory breast cancer (IBC) is a rare type of breast cancer in which the lymph vessels in the breast become blocked by cancerous cells. This type of breast cancer accounts for less than 4 percent of all breast cancer diagnoses, according to the National Cancer Institute, but requires a highly specialized approach to treatment. There are several significant differences between IBC and other types of the disease. Inflammatory breast cancer:
Inflammatory Breast Cancer Research FoundationOne Womans Journey with Inflammatory Breast CancerInflammatory Breast Cancer Research FoundationOne Woman's Journey with Inflammatory Breast Cancer
Follow one womans photo journey from her Inflammatory Breast Cancer diagnosis in 2009 through chemotherapy, surgery, radiation and post-treatment in 2011.
Search of: inflammatory breast cancer AND Modulators - List Results - ClinicalTrials.govSearch of: inflammatory breast cancer AND Modulators - List Results - ClinicalTrials.gov
Progression Free Survival (PFS) Rate of HER2+ Primary de novo Metastatic and Locally Advanced Inflammatory Breast Cancer (IBC) Patients, and HER2-/ER+ IBC Patients Treated with Neratinib Plus Anthracycline and Taxane Based ...
A Survivors Story of Inflammatory Breast CancerA Survivor's Story of Inflammatory Breast Cancer
Sandi Johnson went in for a mammogram and came out with a diagnosis of Inflammatory Breast Cancer. She was swept up in the whirlwind of treatments: chemotherapy, surgery, radiation.
Human Phospho PDGF Pathway Protein Array, 104 Target proteins (HA-PDG-PA) - Creative ProteomicsHuman Phospho PDGF Pathway Protein Array, 104 Target proteins (HA-PDG-PA) - Creative Proteomics
AKT(Ser473), AKT(Thr308), AKT(Tyr326), AKT1(Thr450), AKT1(Thr72), AKT1(Tyr474), AKT2(Ser474), c-Jun(Ser243), c-Jun(Ser63), c-Jun(Ser73), c-Jun(Thr239), c-Jun(Thr91), c-Jun(Thr93), c-Jun(Tyr170), COX2, Elk1(Ser383), Elk1(Ser389), Elk1(Thr417), ERK1/2, ERK3(Ser189), Fos(Thr232), FosB(Ser27), GAP43(Ser41), GRB2(Ser159), GTPase activating protein(Ser387), IkB-alpha(Ser32/36), IkB-alpha(Tyr42), IkB-beta(Thr19), IkB-epsilon(Ser22), IKK alpha(Thr23), IKK beta(Tyr188), IKK beta(Tyr199), IKK gamma(Ser31), IKK gamma(Ser85), IKKa/b(Ser180/181), IP3KA, IP3KC, JAK1(Tyr1022), JAK2(Tyr1007), JAK2(Tyr221), JNK1/2/3(Thr183/Tyr185), JNKK (MKK4), MAP3K1/MEKK1(Thr1381), MEK1(Ser217), MEK1(Ser221), MEK1(Ser298), MEK1(Thr286), MEK1(Thr291), MEK2(Thr394), NFkB-p100/p52(Ser865), NFkB-p105(Ser927), NFkB-p105/p50(Ser337), NFkB-p105/p50(Ser932), NFkB-p65(Ser536), NFkB-p65(Thr254), p44/42 MAPK(Thr202), p44/42 MAPK(Tyr204), PAK1(Ser204), PAK1(Thr212), PAK1/2(Ser199), PAK1/2/3(Ser141), PAK1/2/3(Thr423/402/421), PAK2(Ser192), ...
anti-WISP2 antibody | Rabbit anti-Human WISP2 Polyclonal Antibody-NP 003872.1anti-WISP2 antibody | Rabbit anti-Human WISP2 Polyclonal Antibody-NP 003872.1
Buy anti-WISP2 antibody, Rabbit anti-Human WISP2 Polyclonal Antibody-NP_003872.1 (MBS241096) product datasheet at MyBioSource, Primary Antibodies. Application: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
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RESEARCH DESIGN AND METHODS Levels of CTGF/CCN2 were measured in 952 VADT patients a median of 1.9 years after entry into the study. Participants were followed for an average of 3.3 years for vascular outcomes. CTGF/CCN2 categories were defined as below the detectable limit (referent, 54.5%), lower half of detectable values (22.8%), and upper half of detectable values (22.7%). Hazard ratios (HRs) for cardiovascular end points in relation to CTGF/CCN2 categories were calculated by Cox proportional hazards models. ...
CYR61CYR61
NOV (gene)NOV (gene)
CTGFCTGF
CCNCCN
CCN proteinCCN protein
Matricellular proteinMatricellular protein
WNT1-inducible-signaling pathway protein 1WNT1-inducible-signaling pathway protein 1
WNT1-inducible-signaling pathway protein 3WNT1-inducible-signaling pathway protein 3
Parathyroid hormone-related proteinParathyroid hormone-related protein
配體 (生物化學) - 维基百科，自由的百科全配體 (生物化學) - 维基百科，自由的百科全
Ephrin A4Ephrin A4
Ligand (biochemistry)Ligand (biochemistry)
Ephrin A5Ephrin A5
Transforming growth factor beta superfamilyTransforming growth factor beta superfamily
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
CCN Intercellular Signaling ProteinsNephroblastoma Overexpressed ProteinCysteine-Rich Protein 61Connective Tissue Growth FactorImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsIntegrin alpha6beta1Fibromatosis, GingivalIntegrin alpha5beta1Integrin alphaVbeta3Cell AdhesionConnective Tissue CellsTransforming Growth Factor betaFibrosisFibroblastsInsulin-Like Growth Factor Binding ProteinsSignal TransductionCell MovementGrowth and DevelopmentEar CartilageMurinaeMesangial CellsGene Expression RegulationCells, CulturedNeovascularization, PhysiologicSmad3 ProteinCell ProliferationChondrocytesBibliometricsPublicationsResearchBiomedical ResearchPublishingPubMedAcademies and InstitutesParathyroid Hormone-Related ProteinTooth EruptionReceptor, Parathyroid Hormone, Type 1Parathyroid HormoneReceptors, Parathyroid HormoneMammary Glands, AnimalEncyclopedias as TopicBinding, CompetitiveInterferometryFluorescence PolarizationProtein BindingBinding SitesKineticsRadioligand AssayCopyrightProtein Structure, Tertiary
CCN protein - WikipediaCCN protein - Wikipedia
WNT1-inducible-signaling pathway protein 3 - WikipediaWNT1-inducible-signaling pathway protein 3 - Wikipedia
Ingolf Bachs research topics | Profiles RNSIngolf Bach's research topics | Profiles RNS
Find Research Outputs - the UWA Profiles and Research RepositoryFind Research Outputs - the UWA Profiles and Research Repository
Protocols and Video Articles Authored by Wen-Chi Chen (Translated to Danish)Protocols and Video Articles Authored by Wen-Chi Chen (Translated to Danish)
Parathyroid hormone-related protein - WikipediaParathyroid hormone-related protein - Wikipedia
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family...Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family...
Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent...Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent...
Find Research Outputs - Okayama UniversityFind Research Outputs - Okayama University
Extracellular Matrix Proteins < Scleroproteins << Physiological related proteins <<< Proteins (Protein Science) @...Extracellular Matrix Proteins < Scleroproteins << Physiological related proteins <<< Proteins (Protein Science) @...
Cytokines | Hawaii eBook Library - eBooks | Read eBooks onlineCytokines | Hawaii eBook Library - eBooks | Read eBooks online
Search | Global Index MedicusSearch | Global Index Medicus
配體 (生物化學) - 维基百科，自由的百科全配體 (生物化學) - 维基百科，自由的百科全
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin α5β1<...CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin α5β1<...
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
Ephrin A4 - WikipediaEphrin A4 - Wikipedia
Ingolf Bachs research topics | Profiles RNSIngolf Bach's research topics | Profiles RNS
Adipokines | Harvard Catalyst Profiles | Harvard CatalystAdipokines | Harvard Catalyst Profiles | Harvard Catalyst
Intercellular Signaling Peptides and Proteins - MeSH - NCBIIntercellular Signaling Peptides and Proteins - MeSH - NCBI
Elastin | Profiles RNSElastin | Profiles RNS
Progressive pseudorheumatoid dysplasia: a rare childhood disease. - PubMed - NCBIProgressive pseudorheumatoid dysplasia: a rare childhood disease. - PubMed - NCBI
DeCS 2009 - New termsDeCS 2009 - New terms
Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han...Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han...
Extracellular Matrix Proteins | Profiles RNSExtracellular Matrix Proteins | Profiles RNS
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CCN Intercellular Signaling ProteinsNephroblastoma Overexpressed ProteinCysteine-Rich Protein 61Connective Tissue Growth FactorImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsIntegrin alpha6beta1Fibromatosis, GingivalIntegrin alpha5beta1Integrin alphaVbeta3Cell AdhesionConnective Tissue CellsTransforming Growth Factor betaFibrosisFibroblastsInsulin-Like Growth Factor Binding ProteinsSignal TransductionCell MovementGrowth and DevelopmentEar CartilageMurinaeMesangial CellsGene Expression RegulationCells, CulturedNeovascularization, PhysiologicSmad3 ProteinCell ProliferationChondrocytesBibliometricsPublicationsResearchBiomedical ResearchPublishingPubMedAcademies and InstitutesParathyroid Hormone-Related ProteinTooth EruptionReceptor, Parathyroid Hormone, Type 1Parathyroid HormoneReceptors, Parathyroid HormoneMammary Glands, AnimalEncyclopedias as TopicBinding, CompetitiveInterferometryFluorescence PolarizationProtein BindingBinding SitesKineticsRadioligand AssayCopyrightProtein Structure, Tertiary
PeptidesPathwaysMember of the CCN familyGenesCTGFAmino acidsWISP3Highly conservedCCN2InhibitionWISP1Parathyroid hormonePhosphorylationParacrineRegulatesChondrocytesMoleculeCysteine knotFibroblast growthRegulationEmbryonic developmentReceptorsFibrous proteinsCYR61Extracellular matrixCartilageCompriseRegulateTissuesCell proliferationTumorigenesisMRNA and proteinLigandsCx43GrowthConnectiveTranscriptional coactivatorPhysiologicalInternational consensusEncodeLocalizationBiologicalPI3K
Peptides2
Pathways7
Member of the CCN family2
Genes5
  • Moreover, gene expression levels and the effects of exogenous CCN proteins on chondrocyte proliferation, differentiation, and the expression of chondrocyte-associated genes in their primary chondrocytes were evaluated. (elsevier.com)
  • Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population. (cdc.gov)
  • The genes that encode the ephrin-A and ephrin-B proteins are designated as EFNA and EFNB respectively. (readtiger.com)
  • Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. (biomedcentral.com)
  • In particular, genes downstream of Hippo signaling and the biomechanical sensor and transcriptional coactivator Yes-associated protein (YAP) were downregulated in infected endothelial cells. (asm.org)
CTGF17
Amino acids6
WISP32
Highly conserved2
CCN22
  • CCN2 is best known as a promoter of chondrocyte differentiation among the CCN family members, and its null mice display skeletal dysmorphisms. (elsevier.com)
  • Using both in vivo and in vitro approaches, we conducted a comparative analysis of CCN2-null and wildtype mice to study the roles of CCN2 and the other CCN proteins in cartilage development. (elsevier.com)
Inhibition2
WISP12
  • The mRNA levels of Dickkopf homolog 1(DKK1), Wnt induced secreted protein 1(WISP1), Wnt1, low density lipoprotein receptor related protein 5(LRP5) and beta -catenin in rats cartilaginous tissues were analyzed by using RT-PCR method, and the protein contents of DKK1, WISP1, Wnt1, LRP5 and beta-catenin in cartilaginous tissues were detected by Western blot. (bvsalud.org)
  • Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. (biomedcentral.com)
Parathyroid hormone2
Phosphorylation5
Paracrine1
Regulates3
Chondrocytes2
Molecule5
Cysteine knot2
  • Members of the CCN protein family are characterized by having four conserved cysteine-rich domains, which include the insulin-like growth factor-binding domain (IGFBP), the Von Willebrand factor type C domain (VWC), the thrombospondin type 1 repeat (TSR), and a C-terminal domain (CT) with a cysteine knot motif. (wikipedia.org)
  • The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, von Willebrand type C repeats (vWC) domain, thrombospondin type 1 repeat domain (TSR), and the C-terminal (CT) domain that contains a cysteine-knot motif. (wikipedia.org)
Fibroblast growth1
Regulation6
Embryonic development1
Receptors5
Fibrous proteins2
  • In our body, the gels of polysaccharides and fibrous proteins ( scleroproteins ) fill the interstitial space and act as a compression buffer against the stress placed on the Extracellular Matrix (ECM) . (wellnessadvantage.com)
  • The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g. (rtrn.net)
CYR614
Extracellular matrix1
Cartilage1
  • PURPOSES: Gap junction intercellular communication (GJIC) is essential for articular cartilage to respond appropriately to physical or biological stimuli and maintain homeostasis. (bvsalud.org)
Comprise1
Regulate1
  • Here we show that Drosophila Tctp directly interacts with the septate junction protein Coracle (Cora) to regulate epithelial integrity and organ growth. (bvsalud.org)
Tissues4
Cell proliferation1
Tumorigenesis1
MRNA and protein2
  • CCN gene expression levels were studied at the mRNA and protein level in retinas of control and diabetic rats using real-time quantitative PCR, western blotting and immunohistochemistry at 6 and 12 weeks of streptozotocin-induced diabetes in the presence or absence of aminoguanidine, an AGE inhibitor. (nih.gov)
  • Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis were used to detect mRNA and protein expression of FKN and its receptor, CX3CR1, in HUVECs and BRECs. (arvojournals.org)
Ligands1
Cx432
  • Western blot analysis was done to detect the expression of Cx43 and PI3K/Akt signalling. (bvsalud.org)
  • Using reverse transcription-polymerase chain reaction, western blot analysis, and immunohistochemistry, we found that among the family of gap junction proteins, connexin (Cx) 26, Cx36, Cx37, Cx43, and Cx45 were expressed in the mouse neocortex. (ubc.ca)
Growth9
  • In addition, C57BL/6 mice were repeatedly injected with exogenously formed AGE to establish whether AGE modulate retinal CCN growth factors in vivo. (nih.gov)
  • Huang J, Zhao L, Chen D. Growth factor signalling in osteoarthritis. (rush.edu)
  • Eph/ephrin signaling controls the guidance of neuronal axons through their ability to inhibit the survival of axonal growth cones , which repels the migrating axon away from the site of Eph/ephrin activation. (readtiger.com)
  • Secretion of endothelin-1 (ET-1)1 from the endothelium signals vasoconstriction and influences local cellular growth and survival. (readtiger.com)
  • The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin . (ipfs.io)
  • It is well documented that gap junctional intercellular communication is important in mediating normal cell growth, differentiation, and development. (springer.com)
  • Translationally controlled tumor protein (TCTP) is a conserved protein involved in growth control, but its role in cell junctions is unknown. (bvsalud.org)
  • Ovarian follicular development involves continual remodelling of the extracellular matrix (ECM) forming the basement membrane and intercellular framework that support granulosa cell (GC) growth and differentiation. (bioscientifica.com)
  • Differences observed between asthmatic and non-asthmatic bronchial fibroblasts (e.g., response to transforming growth factor β, cell shape, elasticity, and protein expression profile) may have a crucial influence on this phenomenon. (springer.com)
Connective1
Transcriptional coactivator1
Physiological4
International consensus1
Encode2
Localization2
Biological1
PI3K1
  • Among activated downstream molecules, PI3K, ShcA protein and STAT1 are all confirmed to be involved in the TIE2-R849W related network[ 10 , 11 ]. (medsci.org)
Ingolf Bach's research topics | Profiles RNS
Ingolf Bach's research topics | Profiles RNS (profiles.umassmed.edu)
Find Research Outputs - the UWA Profiles and Research Repository
Find Research Outputs - the UWA Profiles and Research Repository (research-repository.uwa.edu.au)
Cytokines | Hawaii eBook Library - eBooks | Read eBooks online
Cytokines | Hawaii eBook Library - eBooks | Read eBooks online (hawaiilibrary.net)
Extracellular Matrix Proteins < Scleroproteins << Physiological related proteins <<< Proteins (Protein Science) @...
Extracellular Matrix Proteins < Scleroproteins << Physiological related proteins <<< Proteins (Protein Science) @... (wellnessadvantage.com)
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family...
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family... (kyushu-u.pure.elsevier.com)
Ephrin A4 - Wikipedia
Ephrin A4 - Wikipedia (en.wikipedia.org)
Ligand (biochemistry) - Wikipedia
Ligand (biochemistry) - Wikipedia (en.wikipedia.org)
Ephrin A5 - Wikipedia
Ephrin A5 - Wikipedia (en.wikipedia.org)
Extracellular Matrix Proteins | Profiles RNS
Extracellular Matrix Proteins | Profiles RNS (connect.rtrn.net)
Cicatrix | The Chopra Library
Cicatrix | The Chopra Library (isharonline.org)
OBM Genetics | The Changed Transcriptome of Muscular Dystrophy and Inflammatory Myopathy: Contributions of Non-Coding RNAs to...
OBM Genetics | The Changed Transcriptome of Muscular Dystrophy and Inflammatory Myopathy: Contributions of Non-Coding RNAs to... (lidsen.com)
C - Embryology
C - Embryology (embryology.med.unsw.edu.au)
The emerging role of WISP proteins in tumorigenesis and cancer therapy | Journal of Translational Medicine | Full Text
The emerging role of WISP proteins in tumorigenesis and cancer therapy | Journal of Translational Medicine | Full Text (translational-medicine.biomedcentral.com)
Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of...
Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of... (medsci.org)
Plus it
Plus it (plantphysiol.org)
Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration | Development
Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration | Development (dev.biologists.org)
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks...
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks... (genomemedicine.biomedcentral.com)