Ccaat enhancer binding protein beta. Medical search

A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.

A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A member of the C-EBP protein family of transcription factors. It plays a key role in G0 PHASE mammary EPITHELIAL CELL growth arrest, and it is involved in transcriptional regulation of INTERLEUKIN 1; INTERLEUKIN 6; and TUMOR NECROSIS FACTOR-ALPHA.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A CCAAT-enhancer binding protein that is induced by DNA DAMAGE and growth arrest. It serves as a dominant negative inhibitor of other CCAAT-enhancer binding proteins.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The differentiation of pre-adipocytes into mature ADIPOCYTES.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Established cell cultures that have the potential to propagate indefinitely.

An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.

A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.

Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.

A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

Heterotrimeric GTP-binding protein subunits that tightly associate with GTP-BINDING PROTEIN GAMMA SUBUNITS. A dimer of beta and gamma subunits is formed when the GTP-BINDING PROTEIN ALPHA SUBUNIT dissociates from the GTP-binding protein heterotrimeric complex. The beta-gamma dimer can play an important role in signal transduction by interacting with a variety of second messengers.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.

Nucleic acid sequences involved in regulating the expression of genes.

A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. Mutations in HNF-3beta have been associated with CONGENITAL HYPERINSULINISM.

An organochlorine compound that was formerly used as an insecticide. Its manufacture and use has been discontinued in the United States. (From Merck Index, 11th ed)

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.

A component of NF-kappa B transcription factor. It is proteolytically processed from NF-kappa B p105 precursor protein and is capable of forming dimeric complexes with itself or with TRANSCRIPTION FACTOR RELA. It regulates expression of GENES involved in immune and inflammatory responses.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

A cell line derived from cultured tumor cells.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A DNA-directed RNA polymerase found in BACTERIA. It is a holoenzyme that consists of multiple subunits including sigma factor 54.

Transport proteins that carry specific substances in the blood or across cell membranes.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

An anti-inflammatory 9-fluoro-glucocorticoid.

A human cell line established from a diffuse histiocytic lymphoma (HISTIOCYTIC LYMPHOMA, DIFFUSE) and displaying many monocytic characteristics. It serves as an in vitro model for MONOCYTE and MACROPHAGE differentiation.

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. (1/788)

C/EBPalpha and C/EBPbeta are intronless genes that can produce several N-terminally truncated isoforms through the process of alternative translation initiation at downstream AUG codons. C/EBPbeta has been reported to produce four isoforms: full-length 38-kDa C/EBPbeta, 35-kDa LAP (liver-enriched transcriptional activator protein), 21-kDa LIP (liver-enriched transcriptional inhibitory protein), and a 14-kDa isoform. In this report, we investigated the mechanisms by which C/EBPbeta isoforms are generated in the liver and in cultured cells. Using an in vitro translation system, we found that LIP can be generated by two mechanisms: alternative translation and a novel mechanism-specific proteolytic cleavage of full-length C/EBPbeta. Studies of mice in which the C/EBPalpha gene had been deleted (C/EBPalpha-/-) showed that the regulation of C/EBPbeta proteolysis is dependent on C/EBPalpha. The induction of C/EBPalpha in cultured cells leads to induced cleavage of C/EBPbeta to generate the LIP isoform. We characterized the cleavage activity in mouse liver extracts and found that the proteolytic cleavage activity is specific to prenatal and newborn livers, is sensitive to chymostatin, and is completely abolished in C/EBPalpha-/- animals. The lack of cleavage activity in the livers of C/EBPalpha-/- mice correlates with the decreased levels of LIP in the livers of these animals. Analysis of LIP production during liver regeneration showed that, in this system, the transient induction of LIP is dependent on the third AUG codon and most likely involves translational control. We propose that there are two mechanisms by which C/EBPbeta isoforms might be generated in the liver and in cultured cells: one that is determined by translation and a second that involves C/EBPalpha-dependent, specific proteolytic cleavage of full-length C/EBPbeta. The latter mechanism implicates C/EBPalpha in the regulation of posttranslational generation of the dominant negative C/EBPbeta isoform, LIP. (+info)

CCAAT/enhancer-binding proteins are mediators in the protein kinase A-dependent activation of the decidual prolactin promoter. (2/788)

In the course of decidualization, human endometrial stromal cells (ESC) activate the alternative upstream promoter of the decidual prolactin (dPRL) gene. The dPRL promoter is induced by the protein kinase A pathway in a delayed fashion via the region -332/-270 which contains two overlapping consensus binding sequences, B and D, for CCAAT/enhancer-binding proteins (C/EBP). Here we show that sites B and D both bind C/EBPbeta and -delta from ESC nuclear extracts. When decidualization of cultured ESC was induced by treatment with 8-Br-cAMP, complex formation on sites B and D was enhanced. Western blot analysis revealed an elevation of both C/EBPbeta isoforms, liver-enriched activator protein and liver-enriched inhibitory protein, with a delayed onset between 8 and 24 h of cAMP treatment, while C/EBPdelta expression remained unaffected. Cyclic AMP-mediated activation of dPRL promoter construct dPRL-332/luc3 was abrogated by mutation of sites B and D at -310/-285. An expression vector for liver-enriched activator protein potently induced transcription of dPRL-332/luc3 and further enhanced cAMP-mediated induction, while liver-enriched inhibitory protein expression vector abolished the cAMP response, implying that C/EBPs serve as mediators in the delayed cAMP signal transduction to the dPRL promoter. The ratio between activating and repressing isoforms is likely to dictate the transcriptional output. (+info)

CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. (3/788)

The transcription factor CCAAT/enhancer binding protein beta, C/EBPbeta, plays a significant role in the regulation of hepatocyte growth and differentiation. A single mRNA coding for C/EBPbeta produces several protein isoforms. Two pathways for generation of low molecular weight C/EBPbeta isoforms have been described: specific proteolytic cleavage and initiation of translation from different AUG codons of C/EBPbeta mRNA. A truncated C/EBPbeta isoform, LIP, is induced in rat livers in response to partial hepatectomy (PH) via the alternative translation mechanism. Here we present evidence that CUG repeat binding protein, CUGBP1, interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. Two binding sites for CUGBP1 are located side by side between the first and second AUG codons of C/EBPbeta mRNA. One binding site is observed in an out of frame short open reading frame (sORF) that has been previously shown to regulate initiation of translation from different AUG codons of C/EBPbeta mRNA. Analysis of cytoplasmic and polysomal proteins from rat liver after PH showed that CUGBP1 is associated with polysomes that translate low molecular weight isoforms of C/EBPbeta. The binding activity of CUGBP1 to the 5' region of C/EBPbeta mRNA shows increased association with these polysomal fractions after PH. Addition of CUGBP1 into a cell-free translation system leads to increased translation of low molecular weight isoforms of C/EBPbeta. Our data demonstrate that CUGBP1 protein is an important component for the regulation of initiation from different AUG codons of C/EBPbeta mRNA. (+info)

The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. (4/788)

C/EBPalpha, beta, and delta are all expressed by bone marrow-derived macrophages. Ectopic expression of any of these transcription factors is sufficient to confer lipopolysaccharide (LPS)-inducible expression of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) to a B lymphoblast cell line, which normally lacks C/EBP factors and does not display LPS induction of proinflammatory cytokines. Thus, the activities of C/EBPalpha, beta, and delta are redundant in regard to expression of IL-6 and MCP-1. Surprisingly, the bZIP region of C/EBPbeta, which lacks any previously described activation domains, can also confer LPS-inducible expression of IL-6 and MCP-1 in stable transfectants. Transient transfections reveal that the bZIP regions of C/EBPbeta, C/EBPdelta, and, to a lesser extent, C/EBPalpha can activate the IL-6 promoter and augment its induction by LPS. Furthermore, the transdominant inhibitor, LIP, can activate expression from the IL-6 promoter. The ability of the C/EBPbeta bZIP region to activate the IL-6 promoter in transient transfections is completely dependent upon an intact NF-kappaB-binding site, supporting a model where the bZIP protein primarily functions to augment the activity of NF-kappaB. Replacement of the leucine zipper of C/EBPbeta with that of GCN4 yields a chimeric protein that can dimerize and specifically bind to a C/EBP consensus sequence, but shows a markedly reduced ability to activate IL-6 and MCP-1 expression. These results implicate the leucine zipper domain in some function other than dimerization with known C/EBP family members, and suggest that C/EBP redundancy in regulating cytokine expression may result from their highly related bZIP regions. (+info)

Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta. (5/788)

Epidermal keratinocytes respond to injury by becoming activated, i.e. hyperproliferative, migratory, and proinflammatory. These processes are regulated by growth factors and cytokines. One of the markers of activated keratinocytes is keratin K6. We used a novel organ culture system to show that tumor necrosis factor alpha (TNFalpha) induces the expression of K6 protein and mRNA in human skin. Multiple isoforms of K6 are encoded by distinct genes and have distinct patterns of expression. By having shown previously that proliferative signals, such as epidermal growth factor (EGF), induce expression of the cytoskeletal protein keratin K6b, we here demonstrate that the same isoform, K6b, is also induced by TNFalpha, a proinflammatory cytokine. Specifically, TNFalpha induces the transcription of the K6b gene promoter. By using co-transfection, specific inhibitors, and antisense oligonucleotides, we have identified NFkappaB and C/EBPbeta as the transcription factors that convey the TNFalpha signal. Both transcription factors are necessary for the induction of K6b by TNFalpha and act as a complex, although only C/EBPbeta binds the K6b promoter DNA. By using transfection, site-directed mutagenesis, and footprinting, we have mapped the site that responds to TNFalpha, NFkappaB, and C/EBPbeta. This site is separate from the one responsive to EGF and AP1. Our results show that the proinflammatory (TNFalpha) and the proliferative (EGF) signals in epidermis separately and independently regulate the expression of the same K6b keratin isoform. Thus, the cytoskeletal responses in epidermal cells can be precisely tuned by separate proliferative and inflammatory signals to fit the nature of the injuries that caused them. (+info)

NF-IL6 and CRE elements principally account for both basal and interleukin-1 beta-induced transcriptional activity of the proximal 528bp of the PGHS-2 promoter in amnion-derived AV3 cells: evidence for involvement of C/EBP beta. (6/788)

Prostaglandin H synthase (PGHS)-2 promoter fragments (-528 to +9 bp and 5' unidirectional deletions thereof) were cloned upstream of the chloramphenicol acetyl-transferase (CAT) reporter gene. These were transfected into amnion-derived AV3 cells. The region, -528 to -203, which includes NF-kappa B sites, had little influence on CAT expression. The region, -203 and -52, however, was responsible for most of the basal promoter activity and also conferred responsiveness to interleukin (IL)-1 beta (>3-times basal). Point mutations of NF-IL6 and cAMP response element (CRE) in this region reduced both basal and IL-1 beta-stimulated production of CAT; dual mutation eliminated IL-1 beta responsiveness. Factors in nuclear extracts from control or IL-1 beta-stimulated AV3 cells specifically complexed the NF-IL6 and CRE sequences. However, the NF-IL6 and CRE oligonucleotides cross-competed, suggesting a common factor. C/EBP beta was identified by supershift assay as interacting with both sequences. To a lesser extent C/EBP alpha and delta also interacted with the NF-IL6 site. However, CRE binding protein (CREB), was absent from the complex with the CRE. In conclusion, NF-IL6 and CRE elements principally account in AV3 amnion cells for basal and IL-1 beta-inducible transcriptional activity of the proximal 528 bp of the PGHS-2 promoter, while NF-kappa B elements play no substantial role. C/EBPs, particularly C/EBPbeta, are implicated in control of PGHS-2 transcription through the NF-IL6 and CRE sites. (+info)

Multiple regulatory elements in the murine stromelysin-3 promoter. Evidence for direct control by CCAAT/enhancer-binding protein beta and thyroid and retinoid receptors. (7/788)

Stromelysin-3 (ST3) belongs to the matrix metalloproteinase (MMPs) family, a protease family involved in tissue remodeling. Although this family of enzymes is regulated by nuclear receptors, few hormone-responsive elements have been demonstrated in MMP promoters. In order to identify regulatory elements and/or factors that control the expression of the mouse st3 gene, we have analyzed genomic sequences encompassing 5 kilobase pairs of the ST3 promoter. Analysis of these sequences revealed several CCAAT/enhancer-binding proteins (C/EBP) and retinoic acid-responsive elements (RAREs), as well as one thyroid-responsive element. However, in contrast to most MMP promoters, no AP-1-binding sites were identified. Specific binding activities were demonstrated for all elements. Consistent with previous reports, retinoid X receptor is required for maximal binding to the ST3 RAREs and the TRE. The ST3-C/EBP element was shown to mediate dose-dependent promoter activation by C/EBPbeta. Among the RAREs, the proximal DR1-RARE was shown to be sufficient for ST3 promoter activation by ligand-bound retinoid receptors, whereas the two distal DR2-RAREs appear to be involved more in the control of base-line promoter activity. Accordingly, ST3 expression was induced by retinoic acid and was reduced in cells where specific retinoic acid receptors had been inactivated. The involvement of these conserved regulatory elements is discussed in the context of physiological or pathological situations associated with st3 expression. Our findings therefore assign to C/EBP, retinoids, and thyroid hormone important roles in the regulation of ST3 gene expression. (+info)

ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. (8/788)

Interferons (IFNs) regulate the expression of a number of cellular genes by activating the JAK-STAT pathway. We have recently discovered that CCAAAT/enhancer-binding protein-beta (C/EBP-beta) induces gene transcription through a novel IFN response element called the gamma-IFN-activated transcriptional element (Roy, S. K., Wachira, S. J., Weihua, X., Hu, J., and Kalvakolanu, D. V. (2000) J. Biol. Chem. 275, 12626-12632. Here, we describe a new IFN-gamma-stimulated pathway that operates C/EBP-beta-regulated gene expression independent of JAK1. We show that ERKs are activated by IFN-gamma to stimulate C/EBP-beta-dependent expression. Sustained ERK activation directly correlated with C/EBP-beta-dependent gene expression in response to IFN-gamma. Mutant MKK1, its inhibitors, and mutant ERK suppressed IFN-gamma-stimulated gene induction through the gamma-IFN-activated transcriptional element. Ras and Raf activation was not required for this process. Furthermore, Raf-1 phosphorylation negatively correlated with its activity. Interestingly, C/EBP-beta-induced gene expression required STAT1, but not JAK1. A C/EBP-beta mutant lacking the ERK phosphorylation site failed to promote IFN-stimulated gene expression. Thus, our data link C/EBP-beta to IFN-gamma signaling through ERKs. (+info)

The term "acute-phase" describes the rapid onset and short duration of this reaction, which typically lasts for hours to days before resolving as the body's inflammatory response subsides. APR is characterized by a series of molecular events that result in altered expression of genes involved in inflammation, immune response, and tissue repair.

Some key components of an acute-phase reaction include:

1. Cytokine production: Cytokines are signaling molecules released by immune cells, such as white blood cells, that coordinate the immune response. During an APR, cytokine levels increase, triggering a cascade of downstream effects.
2. Leukocyte trafficking: White blood cells migrate towards sites of inflammation or infection, where they phagocytose (engulf and digest) pathogens and cellular debris. This process helps to limit the spread of infection and initiate tissue repair.
3. Coagulation cascade: The APR triggers a complex series of events involving blood coagulation factors, leading to the formation of blood clots and preventing excessive bleeding.
4. Anti-inflammatory response: As the APR progresses, anti-inflammatory cytokines, such as interleukin-10 (IL-10), are produced to dampen the inflammatory response and promote tissue repair.
5. Cellular proliferation: To replace damaged cells and tissues, the APR stimulates cellular proliferation and tissue regeneration.
6. Nutrient mobilization: The APR enhances nutrient uptake and utilization by immune cells, allowing them to mount an effective response to the stress.
7. Hormonal changes: The APR is accompanied by changes in hormone levels, such as the increase in corticotropin-releasing factor (CRF) and cortisol, which help to mobilize energy resources and regulate metabolism.
8. Immune tolerance: The APR helps to establish immune tolerance, preventing excessive or inappropriate immune responses that can lead to autoimmune diseases or allergies.
9. Tissue remodeling: The APR stimulates the remodeling of damaged tissues, allowing for the restoration of normal tissue function.
10. Memory formation: The APR sets the stage for the formation of immunological memory, which enables the immune system to mount a more effective response to future infections or stressors.

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. The protein encoded by this ... "Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta". Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG ... Chen GK, Sale S, Tan T, Ermoian RP, Sikic BI (April 2004). "CCAAT/enhancer-binding protein beta (nuclear factor for interleukin ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ...

https://en.wikipedia.org/wiki/CEBPB

"CEBPB CCAAT enhancer binding protein beta [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. National Institutes of ... SUMOylation can affect protein-protein interactions and affect protein ubiquitination. Palmitoylation is the addition of a ... Table 3. Table of WDCP protein Isoforms and Protein Information. The secondary structure of WDCP Protein Isoform 1 consists of ... WDCP Isoform 1 has no transmembrane domains, actin-binding motifs, ER retention motifs, or Golgi transport signals. The protein ...

https://en.wikipedia.org/wiki/WD_Repeat_and_Coiled_Coil_Containing_Protein

"G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta". The Journal of Biological ... Nevertheless, increasing evidence suggests methylation of non-histone proteins may influence protein stability, protein-protein ... which is involved in protein-protein interactions. The ankyrin repeat domain also contains H3K9me1 and H3K9me2 binding sites. ... Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded ...

https://en.wikipedia.org/wiki/EHMT1

Marchildon, François (2012). "CCAAT/Enhancer Binding Protein Beta is Expressed in Satellite Cells and Controls Myogenesis". ... The proteins responsible for signaling the activation of satellite cells are called mitogens. A mitogen is a small protein that ... The disruption in myofiber integrity is seen in increased plasma levels in muscle proteins. The death of myofibers drives a ... In times of injury, satellite cells in myofibers receive signals to proliferate from proteins in the crushed skeletal muscle. ...

https://en.wikipedia.org/wiki/Myosatellite_cell

Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ... This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the ... Serum response factor has been shown to interact with: ASCC3, ATF6, CEBPB, CREB-binding protein, ELK4, GATA4, GTF2F1, GTF2I, ... "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to ...

https://en.wikipedia.org/wiki/Serum_response_factor

"Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". The ... It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. The protein functions ... Qiao D, Im E, Qi W, Martinez JD (June 2002). "Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 ... "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". The ...

https://en.wikipedia.org/wiki/DNA_damage-inducible_transcript_3

Boruk M, Savory JG, Haché RJ (November 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated ... "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)". Kos M, Reid G, Denger ... March 2000). "Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel ... March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N- ...

https://en.wikipedia.org/wiki/Estrogen_receptor_alpha

... a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of ... Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene. Hepatitis delta virus ( ... Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ...

https://en.wikipedia.org/wiki/CCDC85B

"Conserved amino acids within CCAAT enhancer-binding proteins (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase ... A mitochondrial isozyme of the encoded protein also has been characterized. Click on genes, proteins and metabolites below to ... Wilson HL, McFie PJ, Roesler WJ (2003). "Different transcription factor binding arrays modulate the cAMP responsivity of the ... 2002). "Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site". J. Mol. Biol. ...

https://en.wikipedia.org/wiki/PCK1

Eaton EM, Sealy L (August 2003). "Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier ( ... "A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy ... a novel Axin-binding protein, is involved in downregulation of beta-catenin". Molecular and Cellular Biology. 22 (11): 3803-19 ... Dobreva G, Dambacher J, Grosschedl R (December 2003). "SUMO modification of a novel MAR-binding protein, SATB2, modulates ...

https://en.wikipedia.org/wiki/SUMO3

Eaton EM, Sealy L (Aug 2003). "Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) ... Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC (Oct 2002). "Transcriptional activity of CCAAT/enhancer-binding proteins ... It is a ubiquitin-like protein and functions in a manner similar to ubiquitin in that it is bound to target proteins as part of ... which is an axin-binding protein promoting beta-catenin degradation". The Journal of Biological Chemistry. 276 (42): 39060-6. ...

https://en.wikipedia.org/wiki/SUMO2

"The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression ... NFE2L1 binds DNA as heterodimers with one of small Maf proteins (MAFF, MAFG, MAFK). NFE2L1 has been shown to interact with C- ... β-TrCP also binds to the DSGLC motif, a highly conserved region of CNC-bZIP proteins, in order to poly-ubiquitinate NFE2L1 ... Zhang Y, Lucocq JM, Hayes JD (Mar 2009). "The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is ...

https://en.wikipedia.org/wiki/NFE2L1

Holland MP, Bliss SP, Berghorn KA, Roberson MS (2004). "A role for CCAAT/enhancer-binding protein beta in the basal regulation ... Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene. Dlx3 is a crucial regulator of hair follicle ... Park GT, Denning MF, Morasso MI (2001). "Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C". FEBS Lett. ... "AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta- ...

https://en.wikipedia.org/wiki/DLX3

"Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/ ... CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene. The protein encoded by this ... "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". ... "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb ...

https://en.wikipedia.org/wiki/CEBPD

Podust LM, Krezel AM, Kim Y (January 2001). "Crystal structure of the CCAAT box/enhancer-binding protein beta activating ... "Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal ... "Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal ... The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein ...

https://en.wikipedia.org/wiki/ATF4

CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans. CCAAT/enhancer-binding protein alpha is ... It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma, as well as distinct transcription factors ... For details on the CCAAT structural motif in gene enhancers and on CCAAT/Enhancer Binding Proteins see the specific page. The ... One category of mutations prevent CCAAT/enhancer-binding protein alpha DNA binding by altering its COOH-terminal basic leucine ...

https://en.wikipedia.org/wiki/CEBPA

Chen, GK; Sale, S; Tan, S; Ermoian, RP; Sikic, BI (2004). "CCAAT/enhancer-binding protein beta (nuclear factor for interleukin ... He discovered that deletion of aa335 changes the drug-binding spectrum and is integral to the pharmacophore of P-gp. He also ... 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells". Molecular Pharmacology ...

https://en.wikipedia.org/wiki/Branimir_Ivan_Sikic

CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Ccaat-enhancer-binding proteins ... The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form ... CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene. The C/EBP family of ... "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma". Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine- ...

https://en.wikipedia.org/wiki/CEBPG

"Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B ... "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B ... the protein-encoding mRNA for the transcriptional regulator Pu.1-protein, elevation of Pu.1 protein predisposes defective IgG1 ... Following Dicer cleavage, an Argonaute (Ago) protein binds to the short RNA duplexes, forming the core of a multi-subunit ...

https://en.wikipedia.org/wiki/MiR-155

"Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in ... forkhead box protein A1 (FoxA1), and CCAAT enhancer-binding protein b (C/EBPb)] of FTMT transcription have been identified ( ... Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)". The Biochemical Journal. 339 (3): 751-8. doi:10.1042 ... gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, ...

https://en.wikipedia.org/wiki/Sp1_transcription_factor

Zuo Y, Qiang L, Farmer SR (March 2006). "Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta ... binding protein], PACT (protein activator of the interferon-induced protein kinase), the SMN complex, fragile X mental ... significantly inhibited adipogenesis and repressed induction of the master regulators PPARγ and CCAAT/enhancer-binding protein ... These proteins have three highly positively charged regions, termed AT hooks, that bind the minor groove of AT-rich DNA ...

https://en.wikipedia.org/wiki/MicroRNA

... found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein- ... Resistin-like beta is a protein that in humans is encoded by the RETNLB gene. GRCh38: Ensembl release 89: ENSG00000163515 - ... 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and ... "Entrez Gene: RETNLB resistin like beta". Kubota T, Kawano S, Chih DY, et al. (2001). "Representational difference analysis ...

https://en.wikipedia.org/wiki/RETNLB

... an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.Cancer Res.2001;61:2328-34. ... Paracrine activation of WNT/beta-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.Proc Natl Acad Sci USA. ...

https://en.wikipedia.org/wiki/Serdar_Bulun

"Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins". Biochemical and ... A critical role for nuclear liver X receptors alpha and beta". The Journal of Biological Chemistry. 277 (35): 31900-8. doi: ... Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor ... The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key ...

https://en.wikipedia.org/wiki/Liver_X_receptor_alpha

Boruk M, Savory JG, Haché RJ (November 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated ... the heat shock protein 70 (hsp70) and the protein FKBP4 (FK506-binding protein 4). The endogenous glucocorticoid hormone ... "The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and ... November 1997). "The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U". The Journal of ...

https://en.wikipedia.org/wiki/Glucocorticoid_receptor

... interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box". Gene. 90 (2): 271-9. doi:10.1016/0378- ... Hurley TD, Bosron WF, Hamilton JA, Amzel LM (Sep 1991). "Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic ... Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. GRCh38: ... 2. The primary structure of the gamma 1 protein chain". European Journal of Biochemistry. 145 (3): 447-53. doi:10.1111/j.1432- ...

https://en.wikipedia.org/wiki/ADH1C

"Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Spencer E, Jiang J, Chen ZJ (Feb 1999). "Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP". ... Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ...

https://en.wikipedia.org/wiki/RELA

"A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy ... 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J ... E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein ... "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. ...

https://en.wikipedia.org/wiki/PIAS4

TGF-beta induced apoptosis proteins (TAIP) GATA binding factors (GATA) Ccaat/Enhancer binding protein (CEBP) cAMP-responsive ... "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2020-03-02. "Genomatix - NGS ... element binding proteins (CREB) Vertebrate TATA binding protein factor (VTBP) C5orf46 is largely expressed in salivary glands ... C/EBP homologous protein (CHOP) X-box binding factors (XBBF) TALE homeodomain class recognizing TG motifs (TALE) Human and ...

https://en.wikipedia.org/wiki/C5orf46

Stimulating protein 1, CCAAT/enhancer binding protein, GC box elements and HMG box-containing protein 1. Like previously ... The secondary structure reveals a beta strand at positions 3-9 as well as alpha helices incorporated throughout. One promoter ... "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2021-08-01. (CS1 maint: url- ... PANO1 is a protein which in humans is encoded by the PANO1 gene. PANO1 is an apoptosis inducing protein that is able to ...

https://en.wikipedia.org/wiki/PANO1

"Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ... matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer- ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ... The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It regulates gene expression, ...

https://en.wikipedia.org/wiki/CUTL1

Another aspect of the CCAAT binding motif is the CCAAT/enhancer binding proteins (C/EBPs). They are a group of transcription ... This is composed of three alpha-helices separated by two beta strand-loop domains. Similar to NF-YA, NF-YB has been shown to ... Protein specific binding is required for the CCAAT box activation. These proteins are known as CCAAT box binding proteins/CCAAT ... Ramji, Dpiak P.; Foka, Pelagia (10 May 2002). "Review Article: CCAAT/enhancer-binding proteins: structure, function and ...

https://en.wikipedia.org/wiki/CAAT_box

Transcription factor assessment indicates many potential TATA-binding protein and CCAAT-enhancer-binding proteins sites, along ... of the protein composed of beta sheets. Ligand binding sites are predicted by I-TASSER from positions 377 to 530 in Isoform X1 ... C1orf112 is predicted to interact with a diverse range of proteins, including multiple mitosis-associated proteins. C1orf112 is ... quality-controlled protein-protein association networks, made broadly accessible". Nucleic Acids Research. 45 (D1): D362-D368. ...

https://en.wikipedia.org/wiki/C1orf112

"CCAAT/Enhancer-binding Protein Family Members Recruit the Coactivator CREB-binding Protein and Trigger Its Phosphorylation". ... ERICH4 is not predicted to contain beta-sheets. Program analysis in SWISS-Model proposes a tertiary structure for ERICH4 by ... "CCAAT/enhancer-binding proteins: structure, function and regulation". Biochemical Journal. 365 (3): 561-575. doi:10.1042/ ... As suggested by the protein's name, glutamate-rich protein 4, the protein is most highly composed of glutamic acid amino acids ...

https://en.wikipedia.org/wiki/Glutamate-rich_protein_4

TFG-TEC binds to the proximal promoter region of the ENO3 gene. Click on genes, proteins and metabolites below to link to ... Peshavaria M, Hinks LJ, Day IN (Nov 1989). "Structure of human muscle (beta) enolase mRNA and protein deduced from a genomic ... activator protein 1 and 2, CCAAT box transcription factor/nuclear factor I, and cyclic AMP. Unlike the other enolase genes, ... and two myocyte-specific enhancer-binding factor 1 boxes. Upstream of the first exon lies a TATA-like box and CpG-rich region, ...

https://en.wikipedia.org/wiki/ENO3

Transcription factors, peroxis proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding proteins (C/EBPs) are main ... Choy L, Skillington J, Derynck R (May 2000). "Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte ... cAMP-responsive element binding protein promotes differentiation, while the activation of PPARγ and C/EBPα is also responsive ... T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), GATA2/3, retinoic acid receptor α, and SMAD6/7 don't affect the ...

https://en.wikipedia.org/wiki/Adipogenesis

2003). "Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte ... Qian X, Costa RH (1995). "Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation ... is a protein that in humans is encoded by the FOXA3 gene. HNF-3G is a member of the forkhead class of DNA-binding proteins. ... 2009). "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ...

https://en.wikipedia.org/wiki/FOXA3

Ccaat/Enhancer Binding Protein Vertebrate TATA binding protein factor CCAAT binding factors Activator-, mediator- and TBP- ... The beta-folded sheets occur at many of the key domains, including the EGF-domains, kelch domains, and EGF-laminin domains. ... factor 1 RXR heterodimer binding sites GATA binding factors Nuclear receptor subfamily 2 factors Octamer binding protein EGR/ ... proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be ...

https://en.wikipedia.org/wiki/Multiple_Epidermal_Growth_Factor-like_Domains_8

CCAAT binding factors, or CCAAT enhancer binding proteins were found. The TMEM251 protein is 169 amino acids in length. The ... 4 O-beta-N-acetylglucosamine attachment sites All post-translational modifications are conserved in vertebrates. Using various ... Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. One ... No vertebrate TATA binding protein factors, RNA polymerase transcription factor II B, ...

https://en.wikipedia.org/wiki/Transmembrane_protein_251

"Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA". Mol Cell Biol. 19 ... "U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y". ... SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence". Mol Ther. 15 (8): 1479-1486. ... "Double-target antisense U7 snRNAs promote efficient skipping of an aberrant exon in three human beta-thalassemic mutations". ...

https://en.wikipedia.org/wiki/U7_small_nuclear_RNA

... beta-Barrel alpha-helix transcription factors 4.6 Class: TATA binding proteins 4.6.1 Family: TBP 4.7 Class: HMG-box 4.7.1 ... Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. Depending on ... Heteromeric CCAAT factors 4.8.1 Family: Heteromeric CCAAT factors 4.9 Class: Grainyhead 4.9.1 Family: Grainyhead 4.10 Class: ... RAV Cdx protein family DNA-binding protein Inhibitor of DNA-binding protein Mapper(2) Nuclear receptor, a class of ligand ...

https://en.wikipedia.org/wiki/Transcription_factor

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and ... for beta-cell maturation) combination (called PNM) can lead to the transformation of some cell types into a beta cell-like ... Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) acting as an intracellular ... using the genetic material encoding reprogramming protein factors, recombinant proteins; microRNA, a synthetic, self- ...

https://en.wikipedia.org/wiki/Induced_stem_cells

... differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein ... 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK ... Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is an enzyme that in humans is encoded by the PRKD3 gene. Protein kinase C ... human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C ...

https://en.wikipedia.org/wiki/PRKD3

Ccaat-enhancer binding protein KRAB domain zinc finger protein 57 Krüppel-like C2H2 zinc finger factors Octamer binding protein ... with only a few predicted beta sheets. The tertiary structure is not completely characterized as yet, but a model predicted by ... binding factors Nerve growth factor-induced protein C Myc-associated zinc finger GC-binding factor 2 X-box binding protein 1 ... Coiled-coil domain containing protein 180 (CCDC180) is a protein that in humans is encoded by the CCDC180 gene. This protein is ...

https://en.wikipedia.org/wiki/CCDC180

CCAAT binding protein, and cAMP-responsive element binding protein. Expression of TMEM128 is also regulated at the gene level ... GJB5, also known as Gap junction beta-5 protein or connexin-31.1, which functions as a gap junction. The biological function of ... and GH04J004264 enhancer located upstream of their target gene. TMEM128 sequence also contains many binding sites for various ... "PHYRE2 Protein Fold Recognition Server". www.sbg.bio.ic.ac.uk. Retrieved May 2, 2020. "Transcription factor binding sites for ...

https://en.wikipedia.org/wiki/TMEM128

TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing the PPARγ protein. ... 2003a) CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis Proceedings of the ... The bound proteins were eluted by 10 mM reduced glutathione. Samples were separated by SDS-PAGE, followed by immunoblotting ... This requires the activity of proteins called transcription factors that bind to DNA and switch on the expression of genes. ...

https://elifesciences.org/articles/5615

CCAAT/enhancer binding protein (C/EBP), alpha; ChIP: chromatin immunoprecipitation; EE: energy expenditure; HFD: high-fat diet ... beta; BAPs: brown adipocyte precursors; BAT: brown adipose tissue; BMDMs: bone marrow-derived macrophages; CASP1: caspase 1; ... BACKGROUND & AIMS: Sphingosine 1-phosphate receptors (S1PRs) are a group of G-protein-coupled receptors that confer a broad ... NASH susceptibility and pyroptosis were examined following knockdown of SMS1, protein kinase CÎ´ (PKCÎ´), or the NLR family ...

https://pesquisa.bvsalud.org/brasil/?lang=pt&q=au:Yun,+Ji+Young

protein * CCAAT/enhancer-binding protein beta, CEBPB (. * activating transcription factor 3, ATF3 (. ... and CCAAT enhancer binding protein homologous protein (DDIT3) * BCL2L1 protein protects from DDIT3-dependent apoptosis during ... CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. CATEGORY regulatory , transcription factor SUBCELLULAR ... functions as a dimer to inhibit the DNA-binding activity of C/EBP and liver-enriched activator protein ...

http://genatlas.medecine.univ-paris5.fr/fiche.php?onglet=4&n=724

C EBP beta C EBPbeta C-EBP beta C-EBP-Related Protein 2 C-EBP-beta C-EBPbeta CCAAT Enhancer Binding Protein beta CRP2 Protein ... CCAAT-Enhancer-Binding Protein-beta - Preferred Concept UI. M0164346. Scope note. A CCAAT-enhancer-binding protein found in ... C EBP beta. C EBPbeta. C-EBP beta. C-EBP-Related Protein 2. C-EBP-beta. C-EBPbeta. CCAAT Enhancer Binding Protein beta. CRP2 ... 2001; C-EBP BETA (now CCAAT-ENHANCER-BINDING PROTEIN-BETA) was indexed under DNA-BINDING PROTEINS and NUCLEAR PROTEINS 1994- ...

https://decs.bvsalud.org/en/ths/resource/?id=35343

Regulation of CCAAT/enhancer binding protein-alpha gene transcription by interleukin-6. Atherosclerosis Supplements 5(1), pp. ... Signalling pathways underlying transforming growth factor-beta regulated expression of key genes implicated in the control of ... CCAAT/Enhancer binding proteins: structure, function and regulation. Biochemical Journal 365, pp. 561-575. (10.1042/BJ20020508) ... Regulation of CCAAT/enhancer binding protein-alpha gene transcription by interleukin-6. Atherosclerosis Supplements 5(1), pp. ...

https://profiles.cardiff.ac.uk/staff/ramji

CCAAT/enhancer-binding protein beta. CEBPB. P17676. 1 Reference(s). T16MRU. NACHT, LRR and PYD domains-containing protein 3. ... Mitogen-activated protein kinase 8. MAPK8. P45983. 4 Reference(s). T03VS9. Protein-tyrosine kinase 2-beta. PTK2B. Q14289. 1 ... Heat shock protein beta-1. HSPB1. P04792. 2 Reference(s). T22OPB. Nuclear factor erythroid 2-related factor 2. NFE2L2. Q16236. ... Methyl-CpG-binding protein 2. MECP2. P51608. 1 Reference(s). T04HXV. Cytochrome b-c1 complex subunit 1, mitochondrial. UQCRC1. ...

http://www.badd-cao.net:2345/browse/herb/H0793

In-depth regulome analysis of human monocyte subsets, including transcription and enhancer profiling.Description of metabolomic ... CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage ... PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. ... To globally link enhancers with candidate target promoters, we analyzed CAGE clusters surrounding enhancer regions as well as ...

https://ashpublications.org/blood/article/123/17/e90/32568/Transcription-and-enhancer-profiling-in-human

Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo ... Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo ... Yang ZM 2010 Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during ... Yang ZM 2010 Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during ...

https://rep.bioscientifica.com/view/journals/rep/156/5/REP-18-0145.xml?rskey=4ybMqq&result=1

C-EBP-beta use CCAAT-Enhancer-Binding Protein-beta C-EBP-Related Protein 2 use CCAAT-Enhancer-Binding Protein-beta ... CAAT Enhancer Binding Protein use CCAAT-Enhancer-Binding Proteins CAAT Enhancer Binding Proteins use CCAAT-Enhancer-Binding ... CAAT-Enhancer Binding Protein use CCAAT-Enhancer-Binding Proteins CAAT-Enhancer-Binding Proteins use CCAAT-Enhancer-Binding ... C EBP beta use CCAAT-Enhancer-Binding Protein-beta C EBP delta Protein use CCAAT-Enhancer-Binding Protein-delta ...

https://decs.bvs.br/I/DeCS2017_Alfab-C.htm

CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds ...

https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Obesity+and+CEBPB&Mysubmit=Search

CCAAT enhancer-binding protein ß (C/EBP-beta) and 11HSD2, resulting in a hydrocortisone resistance loop. Thiram inhibited the ... Moreover, binding to receptors ligand binding domains was assessed by molecular modelling. Lead compound also induced the ... The key proteins of NF-κB and MAPK signalling pathways were detected by Western blot and immunofluorescence. The result showed ... Neoplasias Ósseas , Osteossarcoma , Animais , Camundongos , Apoptose , beta Catenina/metabolismo , Neoplasias Ósseas/tratamento ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:Hidrocortisona/farmacologia

EBP-333 reacts with C/EBP-beta or CCAAAT/enhancer-binding protein beta, a transcription factor which is not only critical for ... CCAAT/enhancer-binding protein beta, C/EBP beta, Liver activator protein, LAP, Liver-enriched inhibitory protein, LIP, Nuclear ... EBP-333 reacts with C/EBP-beta or CCAAAT/enhancer-binding protein beta, a transcription factor which is not only critical for ... The supernatant format contains FCS proteins from cell culture medium supplemented with FCS. The serum antibodies contain other ...

https://us.progen.com/anti-C-EBP-beta-mouse-monoclonal-EBP-333-purified/691625

We found that C/EBPalpha/beta and NeuroD formed complexes in vitro and in vivo, and were recruited to all three homologous ... CONCLUSION: We here identify three IE genes as targets for BDNF/TrkB signaling, show that C/EBPalpha and -beta are recruited ... CCAAT-Enhancer-Binding Protein-alpha, CCAAT-Enhancer-Binding Protein-beta, CCAAT-Enhancer-Binding Proteins, Cell ... Nerve Tissue Proteins, Neurons, Promoter Regions, Genetic, Proto-Oncogene Proteins c-fos, Receptor, trkB, Serum Response ...

https://www.imm.ox.ac.uk/publications/324056

GCR increases DNA-binding activity of CCAAT/enhancer binding protein beta (C/EBPbeta) [20]. ... an immunophilin protein of the FK506 binding protein family (for example, FK506 binding protein 4, 59kDa (FKBP4)), and ... GCR interacts with CREB binding protein (CBP) and E1A binding protein p300 (p300) and competes with their transcription factors ... The GCR must be bound to the protein chaperone Heat shock protein 90kDa (HSP90) in order to acquire the high affinity steroid ...

https://commerce.bio-rad.com/en-us/prime-pcr-assays/pathway/development-common-pathways/development-glucocorticoid-receptor-signaling

... role of nonstructural component 5A and CCAAT/enhancer-binding protein ß. J Biol Chem. 2012 Oct 26; 287(44):37340-51. ... Glycogen storage disease type Ia in Argentina: two novel glucose-6-phosphatase mutations affecting protein stability. Mol Genet ... CCAAT-Enhancer-Binding Protein-beta. *Fatty Liver. *Muscle, Skeletal. *Pregnancy. _. Top Journals ...

https://profiles.ouhsc.edu/display/8715

Human CEBPa(CCAAT/Enhancer Binding Protein Alpha) ELISA Kit. *Human CEBPb(CCAAT/Enhancer Binding Protein Beta) ELISA Kit ... Human CEBPa(CCAAT/Enhancer Binding Protein Alpha) ELISA Kit. *Human CEBPb(CCAAT/Enhancer Binding Protein Beta) ELISA Kit ... Rat RBP4(Retinol Binding Protein 4, Plasma) ELISA Kit. *Rat RELA(V-Rel Reticuloendotheliosis Viral Oncogene Homolog A) ELISA ... Rat RBP4(Retinol Binding Protein 4, Plasma) ELISA Kit. *Rat RELA(V-Rel Reticuloendotheliosis Viral Oncogene Homolog A) ELISA ...

https://elisastrip.com/tag/antibodies-bind-to/

Human CEBPb(CCAAT/Enhancer Binding Protein Beta) ELISA Kit. *Human CFB(Complement Factor B) ELISA Kit ... Rat IGFBP1(Insulin Like Growth Factor Binding Protein 1) ELISA Kit. *Rat IGFBP2(Insulin Like Growth Factor Binding Protein 2) ... Rat IGFBP3(Insulin Like Growth Factor Binding Protein 3) ELISA Kit. *Rat IGFBP4(Insulin Like Growth Factor Binding Protein 4) ... Mouse IGFBP1(Insulin Like Growth Factor Binding Protein 1) ELISA Kit. *Mouse IGFBP4(Insulin Like Growth Factor Binding Protein ...

https://www.bestpractice-life.pl/human-klk11kallikrein-11-elisa-kit/

Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and ... CCAAT/enhancer binding protein expression is rapidly extinguished in TA1 adipocyte cells treated with tumor necrosis factor. ... Effects of a beta 3 adrenergic receptor agonist on bone and bone marrow adipocytes in the tibia and lumbar spine of the ... Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra ...

https://www.intechopen.com/chapters/61214

... through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein. Biochem J. Nov 15;392:93- ... Behl C, Davis JB, Lesley R, Schubert D. (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell. Jun 17;77:817-27 ... 1979) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive ... 2006) As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid ...

https://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22094HWAI7111015%22.&searchmode=basic

Mouse CEBPb(CCAAT/Enhancer Binding Protein Beta) ELISA Kit. *Mouse CHRM3(Cholinergic Receptor, Muscarinic 3) ELISA Kit ... Human OASL(2′,5′-Oligoadenylate Synthetase Like Protein) ELISA Kit. *Human OSBPL8(Oxysterol Binding Protein Like Protein 8) ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ... Human PTPLA(Protein Tyrosine Phosphatase Like Protein A) ELISA Kit. *Human PTPN1(Protein Tyrosine Phosphatase, Non Receptor ...

https://1elisakits.com/human-pvrl1poliovirus-receptor-related-protein-1-elisa-kit/

Mouse CEBPb(CCAAT/Enhancer Binding Protein Beta) ELISA Kit. *Mouse CHRM3(Cholinergic Receptor, Muscarinic 3) ELISA Kit ... Human OASL(2′,5′-Oligoadenylate Synthetase Like Protein) ELISA Kit. *Human OSBPL8(Oxysterol Binding Protein Like Protein 8) ... Human OASL(2′,5′-Oligoadenylate Synthetase Like Protein) ELISA Kit. *Human OSBPL8(Oxysterol Binding Protein Like Protein 8) ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ...

https://www.lotuskringpoeldijk.nl/human-ap2m1adaptor-related-protein-complex-2-mu-1-elisa-kit/

CEBPA: CCAAT enhancer binding protein alpha. *CEP57: centrosomal protein 57. *CEP290: centrosomal protein 290 ... CBS: cystathionine beta-synthase. *CCBE1: collagen and calcium binding EGF domains 1 ... CHD2: chromodomain helicase DNA binding protein 2. *CHD3: chromodomain helicase DNA binding protein 3 ... CHD7: chromodomain helicase DNA binding protein 7. *CHD8: chromodomain helicase DNA binding protein 8 ...

https://medlineplus.gov/genetics/gene-c/

Glucocorticoids exert their function by binding to the glucocorticoid receptor (GR). Physiological concentrations of ... The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs) are ... beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. J Biol Chem. 2002;277(49): ... correlation with CCAAT-enhancer binding protein expression. Bone. 2002;30(5):685-91. ...

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1498-0

... adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β ... Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the ... Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein. Piao, L., Li, Y., ... q subcomponent binding protein (C1QBP) through physical interaction. Choi, C. Y., Oh, H. N., Lee, S. J. & Chun, T., 2015 Nov, ...

https://pure.korea.ac.kr/en/persons/taehoon-chun/publications/?page=1&ordering=title&descending=false

Ramji DP, Foka P: CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J. 2002, 365: 561-575. ... Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le MN: Suppression of oxidative stress by beta-hydroxybutyrate, an ... show that Ppargc1a can bind and thereby direct p53 to the promoters/enhancers of pro-arrest as well as metabolic target genes. ... compare SM mRNA at the 24 h time point with protein levels in Figure 6A) could be explained by the fact that Ddit4 protein ...

https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-758

Peroxisome proliferator-activated receptors-γ2 (PPAR-γ2), CCAAT/enhancer binding protein (C/EBP), and retinoic C receptor have ... plays a principal role in the migration of human lung resident MSCs through a signaling pathway involving LPA1-induced beta- ... activated by Epac leads to the activation of protein kinase B (PKB)/cAMP response element-binding protein (CREB) signaling and ... Other than core binding factor alpha-1/osteoblast-specific factor-2 (cbfa1/osf2) [23], Wnt signaling has also been implicated ...

https://www.giostar.com/news/therapeutic-potential-mesenchymal-stem-cells-regenerative-medicine/

Bone Morphogenetic Protein 6) ELISA Kit based in Delhi, India ... Rat C/EBP(CCAAT/Enhancer Binding Protein, Delta) ELISA Kit. * ... Mueller Hinton Fastidious Agar (Horse blood 5% + 20 mg/L beta-NAD) (140mm) ... Rat CHD3(Chromodomain Helicase DNA Binding Protein 3) ELISA Kit. *Rat CHD5(Chromodomain Helicase DNA Binding Protein 5) ELISA ... Rat MBP-C/MBL2(Mannma Binding Protein C/Mannan Binding Lectin 2) ELISA Kit ...

https://www.srgroupchemical.com/rat-bmp-6-bone-morphogenetic-protein-6-elisa-kit-4420653.html

CCAAT enhancer binding protein be.... Cited2. 10370. CITED2. Cbp/p300 interacting transactivat.... ... HE_LIM_SUN_FETAL_LUNG_C4_T_ALPHA_BETA_ENTRY_CELL HE_LIM_SUN_FETAL_LUNG_C4_TH17_CELL HE_LIM_SUN_FETAL_LUNG_C4_TREG_CELL HE_LIM_ ... ZHOU_PANCREATIC_BETA_CELL ZHOU_PANCREATIC_ENDOCRINE_PROGENITOR ZHOU_PANCREATIC_EXOCRINE_PROGENITOR ... fatty acid binding protein 1 [Sou.... Fabp4. 2167. FABP4. fatty acid binding protein 4 [Sou.... ...

https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MA_RAT_AGING_DN.html

Mouse CEBPb(CCAAT/Enhancer Binding Protein Beta) ELISA Kit. *Mouse CHRM3(Cholinergic Receptor, Muscarinic 3) ELISA Kit ... Human OASL(2′,5′-Oligoadenylate Synthetase Like Protein) ELISA Kit. *Human OSBPL8(Oxysterol Binding Protein Like Protein 8) ... Human OASL(2′,5′-Oligoadenylate Synthetase Like Protein) ELISA Kit. *Human OSBPL8(Oxysterol Binding Protein Like Protein 8) ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ...

https://www.lotusbiotechnologies.com/tag/enzymes-function/

The alpha-isoform of the CCAAT/enhancer-binding protein is required for mediating cAMP responsiveness of the ... Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule.. Kolanus W,Nagel W, ... Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein ... Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of ...

https://cellbank.nibiohn.go.jp/~cellbank/en/search_res_det.cgi?RNO=JCRB1054

Other immunophilins or heat shock proteins (for example, HSP70 ) that are found associated with unliganded steroid receptors are likely to be involved in the maturation of the receptor to its hormone-binding conformation. (bio-rad.com)
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription. (ox.ac.uk)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poliovirus Receptor Related Protein 1 (PVRL1) in Tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
Description: A sandwich ELISA kit for detection of Poliovirus Receptor Related Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Glucocorticoids exert their function by binding to the glucocorticoid receptor (GR). Physiological concentrations of glucocorticoids stimulate osteoblast proliferation and promote osteogenic differentiation of MSCs. (biomedcentral.com)
Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. (go.jp)

Do the antibodies contain any other proteins? (progen.com)
The serum antibodies contain other proteins present in serum. (progen.com)

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. (go.jp)

This requires the activity of proteins called transcription factors that bind to DNA and switch on the expression of genes. (elifesciences.org)
GCR mediates transactivation of target genes by binding glucocorticoid response elements in their promoter region. (bio-rad.com)
CONCLUSION: We here identify three IE genes as targets for BDNF/TrkB signaling, show that C/EBPalpha and -beta are recruited along with NeuroD to target promoters, and that C/EBPs are essential mediators of Trk signaling in cortical neurons. (ox.ac.uk)
The UPR restores ER homeostasis by attenuating protein synthesis or by inducing the expression of various genes encoding molecular chaperones and protein processing enzymes that promote protein folding and post-translational modification. (molcells.org)

Description: A sandwich ELISA kit for detection of Adaptor Related Protein Complex 2 Mu 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)

GCR and corepressor NCOA2 inhibit Activator protein 1 ( AP-1 ) and so induce AP-1 -mediated gene expression, for example Matrix metallopeptidase 13 ( MMP-13 ). (bio-rad.com)
Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene. (go.jp)

OBJECTIVE: 18F-FP-CIT positron emission tomography (PET) is known for its high sensitivity and specificity for evaluating striatal dopamine transporter (DAT) binding. (bvsalud.org)
This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. (blogspot.com)

These transmembrane proteins are major transducers of the UPR in mammals and mediate multiple distinct signals from the ER to the cytosol. (molcells.org)

Upon administration, C3-targeted complement inhibitor APL-2 selectively binds to C3 and blocks the cleavage of C3 into C3a and C3b by C3 convertase. (blogspot.com)

The GR is an intracellular protein that is ubiquitously expressed in almost every cell of the organism and interacts with chromatin to modulate the activity of numerous transcription factors in a cell type-specific manner. (biomedcentral.com)
Biochemical characterization and intracellular localization of the Menkes disease protein. (go.jp)

Here, we show that a novel ubiquitin E3 ligase, tripartite motif protein 23 (TRIM23), stabilizes PPARγ protein and mediates atypical polyubiquitin conjugation. (elifesciences.org)

Due to the structural similarity to adenosine, caffeine binds to and blocks adenosine receptors, thereby preventing the inhibitory effects of adenosine on nerve cells. (blogspot.com)

GCR can interact productively with the POU class 2 homeobox 1 and 2 ( Oct-1 and Oct-2 ) proteins to recruit them to DNA and this contributes to activation of transcription by Oct from glucocorticoid-responsive promoters [ 17 ], [ 18 ]. (bio-rad.com)

Although the exact mode of action through which cadazolid exerts its effect has yet to be fully elucidated, upon administration, this agent inhibits bacterial protein synthesis and leads to bacterial cell death. (blogspot.com)

analyzed this process in mouse cells and identified a protein called TRIM23 that is produced in precursor cells. (elifesciences.org)
Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues throughout the body. (intechopen.com)
Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells. (go.jp)
The alpha-isoform of the CCAAT/enhancer-binding protein is required for mediating cAMP responsiveness of the phosphoenolpyruvate carboxykinase promoter in hepatoma cells. (go.jp)
Stratified squamous epithelial-specific expression in cultured cells is mediated by binding of Sp1 and ets transcription factors to a proximal promoter element. (go.jp)

Unligated cytoplasmic GCR exists as a heteromeric complex that contains a dimer of HSP90 , an immunophilin protein of the FK506 binding protein family (for example, FK506 binding protein 4, 59kDa ( FKBP4 )), and Prostaglandin E synthase 3 ( p23 co-chaperone ). (bio-rad.com)
Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. (go.jp)

CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (cdc.gov)
The GCR gene encodes two splicing variants, GCR-alpha and GCR-beta [ 1 ], [ 2 ]. (bio-rad.com)

The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and modification, and lipid synthesis and calcium storage. (molcells.org)

The GCR must be bound to the protein chaperone Heat shock protein 90kDa ( HSP90 ) in order to acquire the high affinity steroid binding conformation [ 3 ]. (bio-rad.com)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adaptor Related Protein Complex 2 Mu 1 (AP2m1) in Tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
Protein quality control is monitored by a complex system that modulates ER function to resolve ER stress and dysfunction. (molcells.org)

Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. (blogspot.com)

GCR-alpha binding to NF-kB leads to inactivation of both proteins [ 13 ]. (bio-rad.com)

These enhancer regions are subsequently inherited by late enhanceosomes. (elifesciences.org)
We found that C/EBPalpha/beta and NeuroD formed complexes in vitro and in vivo, and were recruited to all three homologous promoter regions. (ox.ac.uk)

It is known from previous work that TRIM23 belongs to a family of enzymes that attach a small molecular tag called ubiquitin onto other proteins. (elifesciences.org)
This ubiquitin tag typically marks these proteins for rapid destruction by a large molecular machine called the proteasome. (elifesciences.org)

If the amount of PPARγ bound to DNA is too low, then it is unable to activate gene expression. (elifesciences.org)
Significant decreases were observed in the levels of hematocrit, hemoglobin, erythrocytes, triglycerides and total protein and catalase, H+-ATPase, and GpX gene expression. (bvsalud.org)

Dysregulation of ER functions leads to the accumulation of misfolded- or unfolded-protein in the ER lumen, and this triggers the unfolded protein response (UPR), which restores ER homeostasis. (molcells.org)

TRIM23 knockdown caused a marked decrease in PPARγ protein abundance during preadipocyte differentiation, resulting in a severe defect in late adipogenic differentiation, whereas it did not affect the formation of early enhanceosomes. (elifesciences.org)
Our results suggest that TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing PPARγ protein possibly via atypical polyubiquitin conjugation. (elifesciences.org)

Anatomy13

Organisms3

Diseases1

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes24

Information Science3

C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. (1/788)

CCAAT/enhancer-binding proteins are mediators in the protein kinase A-dependent activation of the decidual prolactin promoter. (2/788)

CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. (3/788)

The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. (4/788)

Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta. (5/788)

NF-IL6 and CRE elements principally account for both basal and interleukin-1 beta-induced transcriptional activity of the proximal 528bp of the PGHS-2 promoter in amnion-derived AV3 cells: evidence for involvement of C/EBP beta. (6/788)

Multiple regulatory elements in the murine stromelysin-3 promoter. Evidence for direct control by CCAAT/enhancer-binding protein beta and thyroid and retinoid receptors. (7/788)

ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. (8/788)

No images available that match "ccaat enhancer binding protein beta"

CCAAT-Enhancer-Binding Protein-beta

CCAAT-Enhancer-Binding Proteins

CCAAT-Enhancer-Binding Protein-alpha

Promoter Regions, Genetic

CCAAT-Enhancer-Binding Protein-delta

Gene Expression Regulation

Transcriptional Activation

Binding Sites

DNA-Binding Proteins

Enhancer Elements, Genetic

Transcription Factors

Cells, Cultured

Transcription, Genetic

Nuclear Proteins

Transfection

Transcription Factor CHOP

Base Sequence

RNA, Messenger

Adipocytes

Molecular Sequence Data

Adipogenesis

Cell Differentiation

Protein Binding

Cell Line

Electrophoretic Mobility Shift Assay

3T3-L1 Cells

Response Elements

Cell Nucleus

Granulocytes

Gene Expression

3T3 Cells

PPAR gamma

Liver

Down-Regulation

Myelopoiesis

Signal Transduction

Chromatin Immunoprecipitation

GTP-Binding Protein beta Subunits

Blotting, Western

Genes, Reporter

Trans-Activators

DNA

Luciferases

Leucine Zippers

Mutation

Tumor Cells, Cultured

Up-Regulation

DNA Primers

Protein Isoforms

Mice, Knockout

Gene Expression Regulation, Enzymologic

Adipose Tissue

Regulatory Sequences, Nucleic Acid

Hepatocyte Nuclear Factor 3-beta

Endrin

Reverse Transcriptase Polymerase Chain Reaction

Cyclic AMP Response Element-Binding Protein

Acute-Phase Reaction

NF-kappa B p50 Subunit

HeLa Cells

Mice, Inbred C57BL

Mice, Transgenic

Cell Line, Tumor

Amino Acid Sequence

RNA Polymerase Sigma 54

Carrier Proteins

NF-kappa B

Phosphorylation

Dexamethasone

U937 Cells

Transcription Factor AP-2

C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. (1/788)

CCAAT/enhancer-binding proteins are mediators in the protein kinase A-dependent activation of the decidual prolactin promoter. (2/788)

CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. (3/788)

The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. (4/788)

Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta. (5/788)

NF-IL6 and CRE elements principally account for both basal and interleukin-1 beta-induced transcriptional activity of the proximal 528bp of the PGHS-2 promoter in amnion-derived AV3 cells: evidence for involvement of C/EBP beta. (6/788)

Multiple regulatory elements in the murine stromelysin-3 promoter. Evidence for direct control by CCAAT/enhancer-binding protein beta and thyroid and retinoid receptors. (7/788)

ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. (8/788)

CEBPB