A heterotrimeric DNA-binding protein that binds to CCAAT motifs in the promoters of eukaryotic genes. It is composed of three subunits: A, B and C.
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.
Y-box-binding protein 1 was originally identified as a DNA-binding protein that interacts with Y-box PROMOTER REGIONS of MHC CLASS II GENES. It is a highly conserved transcription factor that regulates expression of a wide variety of GENES.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.
A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
A member of the C-EBP protein family of transcription factors. It plays a key role in G0 PHASE mammary EPITHELIAL CELL growth arrest, and it is involved in transcriptional regulation of INTERLEUKIN 1; INTERLEUKIN 6; and TUMOR NECROSIS FACTOR-ALPHA.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Individual's rights to obtain and use information collected or generated by others.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. (1/416)

The ergosterol biosynthetic pathway is a specific branch of the mevalonate pathway. Since the cells requirement for sterols is greater than for isoprenoids, sterol biosynthesis must be regulated independently of isoprenoid biosynthesis. In this study we explored the transcriptional regulation of squalene synthase (ERG9) in Saccharomyces cerevisiae, the first enzyme dedicated to the synthesis of sterols. A mutant search was performed to identify genes that were involved in the regulation of the expression of an ERG9-lacZ promoter fusion. Mutants with phenotypes consistent with known sterol biosynthetic mutations (ERG3, ERG7, ERG24) increased expression of ERG9. In addition, treatment of wild-type cells with the sterol inhibitors zaragozic acid and ketoconazole, which target squalene synthase and the C-14 sterol demethylase respectively, also caused an increase in ERG9 expression. The data also demonstrate that heme mutants increased ERG9 expression while anaerobic conditions decreased expression. Additionally, the heme activator protein transcription factors HAP1 and HAP2/3/4, the yeast activator protein transcription factor yAP-1, and the phospholipid transcription factor complex INO2/4 regulate ERG9 expression. ERG9 expression is decreased in hap1, hap2/3/4, and yap-1 mutants while ino2/4 mutants showed an increase in ERG9 expression. This study demonstrates that ERG9 transcription is regulated by several diverse factors, consistent with the idea that as the first step dedicated to the synthesis of sterols, squalene synthase gene expression and ultimately sterol biosynthesis is highly regulated.  (+info)

Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex. (2/416)

The observation that cyclin B1 protein and mRNAs are down-regulated in terminally differentiated (TD) C2C12 cells, suggested us to investigate the transcriptional regulation of the cyclin B1 gene in these cells. Transfections of cyclin B1 promoter constructs indicate that two CCAAT boxes support cyclin B1 promoter activity in proliferating cells. EMSAs demonstrate that both CCAAT boxes are recognized by the trimeric NF-Y complex in proliferating but not in TD cells. Transfecting a dominant-negative mutant of NF-YA we provide evidence that NF-Y is required for maximal promoter activity. Addition of recombinant NF-YA to TD C2C12 nuclear extracts restores binding activity in vitro, thus indicating that the loss of NF-YA in TD cells is responsible for the lack of the NF-Y binding to the CCAAT boxes. Consistent with this, we found that the NF-YA protein is absent in TD C2C12 cells. In conclusion, our data demonstrate that NF-Y is required for cyclin B1 promoter activity. We also demonstrate that cyclin B1 expression is regulated at the transcriptional level in TD C2C12 cells and that the switch-off of cyclin B1 promoter activity in differentiated cells depends upon the loss of a functional NF-Y complex. In particular the loss of NF-YA protein is most likely responsible for its inactivation.  (+info)

Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays. (3/416)

The yeast SWI/SNF complex is required for the transcription of several yeast genes and has been shown to alter nucleosome structure in an ATP-dependent reaction. In this study, we show that the complex stimulated in vitro transcription from nucleosome templates in an activation domain-dependent manner. Transcription stimulation by SWI/SNF required an activation domain with which it directly interacts. The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts. The similarity of activation domain interactions and transcriptional stimulation between SWI/SNF and the SAGA histone acetyltransferase complex may account for their apparent overlapping functions in vivo.  (+info)

Identification of proteins that interact with NF-YA. (4/416)

We used the yeast two-hybrid system to show that the serum response factor (SRF) and zinc-fingers and homeobox 1 (ZHXI) proteins interact with the A subunit of nuclear factor-Y (NF-YA). GST pulldown assays revealed that both proteins interact specifically with NF-YA in vitro. Amino acids located between 272 and 564, a region that contains two homeodomains, are required for the interaction of ZHX1 with NF-YA. Two different domains of NF-YA, a glutamine-rich region and a serine/threonine-rich region, are necessary for the interactions with ZHX1 and SRF, respectively.  (+info)

A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene. (5/416)

Proper regulation of the human CD34 gene requires a combinatorial action of multiple proximal and long-range, cis elements. This report shows that, like the murine CD34 5' untranslated region (UTR), the corresponding region of the human CD34 gene is necessary for optimal promoter activity. We localized the most critical element of this region to base pairs +48/+75. Through oligonucleotide competition and antibody supershift experiments in electrophoretic mobility shift assays, we found that this sequence contains a binding site (CCAAT box) for the transcription factor NFY (nuclear factor Y), a factor mediating cell type-specific and cell-cycle regulated expression of genes. Mutating this site led to a 5-fold decrease in CD34 promoter activity in transient transfection experiments. Interestingly, NFY binds adjacently to the earlier identified c-myb binding site. Here we show that both binding sites are important for CD34 promoter function: mutating either site alone decreased CD34 promoter-driven reporter gene activity 4-fold. We also show that the integrity of the c-myb binding site is necessary for stabilization of NFY binding to its site. Such cooperation between c-myb, which is expressed in early hematopoietic cells, and NFY, which is expressed in many cell types, might contribute to specific activation of CD34 in stem cells. The CCAAT box motif was also noted in the 5' UTR of the murine CD34 gene, however, NFY did not bind to this region. Thus, our results indicate that the functional similarities between the human and murine CD34 5' UTRs are achieved through different molecular mechanism(s).  (+info)

Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene. (6/416)

5812 base pairs of rat GTP cyclohydrolase I (GTPCH) 5'-flanking region were cloned and sequenced, and the transcription start site was determined for the gene in rat liver. Progressive deletion analysis using transient transfection assays of luciferase reporter constructs defined the core promoter as a highly conserved 142-base pair GC-rich sequence upstream from the cap site. DNase I footprint analysis of this region revealed (5' --> 3') a Sp1/GC box, a noncanonical cAMP-response element (CRE), a CCAAT-box, and an E-box. Transcription from the core promoter in PC12 but not C6 or Rat2 cells was enhanced by incubation with 8-bromo-cyclic AMP. Mutagenesis showed that both the CRE and CCAAT-box independently contribute to basal and cAMP-dependent activity. The combined CRE and CCAAT-box cassette was also found to enhance basal transcription and confer cAMP sensitivity on a heterologous minimal promoter. The addition of the Sp1/GC box sequence to this minimal promoter construct inhibited basal transcription without affecting the cAMP response. EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor (ATF)-4 and CCAAT enhancer-binding protein beta, while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT-box as a complex containing nuclear factor Y. Overexpression of ATF-4 in PC12 cells was found to transactivate the GTPCH promoter response to cAMP. These studies suggest that the elements required for cell type-specific cAMP-dependent enhancement of gene transcription are located along the GTPCH core promoter and include the CRE and adjacent CCAAT-box and the proteins ATF-4, CCAAT enhancer-binding protein beta, and nuclear factor Y.  (+info)

Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. (7/416)

To understand cholesterol-mediated regulation of human fatty acid synthase promoter I, we tested various 5'-deletion constructs of promoter I-luciferase reporter gene constructs in HepG2 cells. The reporter gene constructs that contained only the Sp-1-binding site (nucleotides -82 to -74) and the two tandem sterol regulatory elements (SREs; nucleotides -63 to -46) did not respond to cholesterol. Only the reporter gene constructs containing a nuclear factor-Y (NF-Y) sequence, the CCAAT sequence (nucleotides -90 to -86), an Sp-1 sequence, and the two tandem SREs responded to cholesterol. The NF-Y-binding site, therefore, is essential for cholesterol response. Mutating the SREs or the NF-Y site and inserting 4 bp between the Sp-1- and NF-Y-binding sites both resulted in a minimal cholesterol response of the reporter genes. Electrophoretic mobility-shift assays using anti-SRE-binding protein (SREBP) and anti-NF-Ya antibodies confirmed that these SREs and the NF-Y site bind the respective factors. We also identified a second Sp-1 site located between nucleotides -40 and -30 that can substitute for the mutated Sp-1 site located between nucleotides -82 and -74. The reporter gene expression of the wild-type promoter and the Sp-1 site (nucleotides -82 to -74) mutant promoter was similar when SREBP1a [the N-terminal domain of SREBP (amino acids 1-520)] was constitutively overexpressed, suggesting that Sp-1 recruits SREBP to the SREs. Under the same conditions, an NF-Y site mutation resulted in significant loss of reporter gene expression, suggesting that NF-Y is required to activate the cholesterol response.  (+info)

Redirection of the respiro-fermentative flux distribution in Saccharomyces cerevisiae by overexpression of the transcription factor Hap4p. (8/416)

Reduction of aerobic fermentation on sugars by altering the fermentative/oxidative balance is of significant interest for optimization of industrial production of Saccharomyces cerevisiae. Glucose control of oxidative metabolism in baker's yeast is partly mediated through transcriptional regulation of the Hap4p subunit of the Hap2/3/4/5p transcriptional activator complex. To alleviate glucose repression of oxidative metabolism, we constructed a yeast strain with constitutively elevated levels of Hap4p. Genetic analysis of expression levels of glucose-repressed genes and analysis of respiratory capacity showed that Hap4p overexpression (partly) relieves glucose repression of respiration. Analysis of the physiological properties of the Hap4p overproducer in batch cultures in fermentors (aerobic, glucose excess) has shown that the metabolism of this strain is more oxidative than in the wild-type strain, resulting in a significant reduced ethanol production and improvement of growth rate and a 40% gain in biomass yield. Our results show that modification of one or more transcriptional regulators can be a powerful and a widely applicable tool for redirection of metabolic fluxes in microorganisms.  (+info)

Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.. ...
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Protein complex formation highly depends on the interplay between preorganization and flexibility of involved binding epitopes. The design of epitope mimetics mainly focuses on the stabilization of a particular bioactive conformation often not considering the conformational dynamics. This limits the potential of peptidomimetics in particular when aiming for challenging targets such as transcription factors. Here, we report the first peptide-derived inhibitor of the NF-Y transcription factor by first constraining the conformation of an epitope using the hydrocarbon stapling approach and then fine-tuning its flexibility. In the initial set of constrained peptides, we observed a severe effect of a single non-interacting alpha-methyl group on complex stability. The combination of X-ray and NMR structures as well as isothermal titration calorimetry and CD spectroscopy reveal how this methyl group affects the conformation of the peptide in its bound state. Adaption of the methylation pattern results ...
The genes coding for the A and B subunits of the transcription factor NF-Y are assigned by a combination of in situ hybridization and analysis of somatic cell hybrids and recombinant mouse strains. NF-YA is assigned to human chromosome 6p21 and to mouse chromosome 17. NF-YB is assigned to human chromosome 12 and to mouse chromosome 10.
TransAM NF-YA Kits are DNA-binding ELISAs that quantify activated NF-YA (nuclear factor Y, alpha) using a method that is faster and more sensitive than gelshift, without radioactivity and gels.
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of loci miR156 ND d 1 miR159 MYB and TCP TFs e b 2 miR160 ND d 1 miR162 DICER-LIKE 1 b 1 miR164 ND a 1 miR166 HD-Zip TFs f, h, k h, k, n h, n c 9 miR167 Auxin response factors TFs a, d, f j d a 6 miR168 ARGONAUTE b 1 miR169 CCAAT binding factor and HAP2-like TFs n, p c 3 miR171 SCARECROW-like TFs c, e, f c c, d a 7 miR319 ND a 1 miR395 ATP sulphurylases i, j, k 3 miR396 GRF TFs, rhodenase-like, and kinesin-like protein B b 1 miR397 Laccases and beta-6 tubulin a a 2 miR399 Phosphatase TFs e b, e 3 miR418 ND x x 2 miR420 ND x x x 3 miR441 ND b a, b, c c 5 miR442 ND x x x 3 miR446 ND x x x 3 miR531 ND x x 2 miR535 ND x x x x 4 Total no. [score:1] ...
of loci miR156 ND d 1 miR159 MYB and TCP TFs e b 2 miR160 ND d 1 miR162 DICER-LIKE 1 b 1 miR164 ND a 1 miR166 HD-Zip TFs f, h, k h, k, n h, n c 9 miR167 Auxin response factors TFs a, d, f j d a 6 miR168 ARGONAUTE b 1 miR169 CCAAT binding factor and HAP2-like TFs n, p c 3 miR171 SCARECROW-like TFs c, e, f c c, d a 7 miR319 ND a 1 miR395 ATP sulphurylases i, j, k 3 miR396 GRF TFs, rhodenase-like, and kinesin-like protein B b 1 miR397 Laccases and beta-6 tubulin a a 2 miR399 Phosphatase TFs e b, e 3 miR418 ND x x 2 miR420 ND x x x 3 miR441 ND b a, b, c c 5 miR442 ND x x x 3 miR446 ND x x x 3 miR531 ND x x 2 miR535 ND x x x x 4 Total no. [score:1] ...
There is evidence that transcriptional control of topo IIα regulation is important in regulating gene expression at confluence (Isaacs et al., 1996), and under heat-shock conditions (Furukawa et al., 1998). A recent study indicated that transcriptional elements may regulate the cell cycle control of topo IIα expression (Falck et al., 1999). Furthermore, p53 may directly repress the promoter (Sandri et al., 1996b; Wang et al., 1997). The oncogenes ras andmyb have also been demonstrated to act through specific sequences within the topo IIα promoter. Both heat-shock and cell cycle regulation have been demonstrated to act through the ICB1 in the promoter (Falck et al., 1999), whereas confluence-induced down-regulation is regulated through the ICB2. This study confirms that, unlike with cell cycle regulation, the transcription factor NF-Y forms part of the ICB binding complex. There is an alteration in the intensity of the in vitro footprint seen at confluence, although this is not associated with ...
This regulatory mechanism functions in two ways. If the downstream genes possess the binding elements of both GmZF392 and GmZF351 in their promoters, the two TZF proteins would play additively roles in activating downstream genes. But for some target genes, only one kind of binding elements is found in their promoter regions. In this case, GmZF392 and GmZF351 form a transcriptional complex to synergistically activate gene expression. Either way could guarantee the participation of the two TZF proteins, so that the downstream genes are up-regulated by two TZF proteins to a much higher level than by only one of them. The third member of this module is a nuclear factor Y subunit, namely GmNFYA. GmNFYA acts as an upstream activator of GmZF392 and GmZF351 in direct and indirect manner respectively ...
d - 40 mm. D - 80 mm. B - 18 mm. C - 18 mm. d2 - 53,6 mm. r1 min. - 1,1 mm. r2 min. - 1,1 mm. D1 - 68,8 mm. da min. - 47 mm. Da max. - 73 mm. ra max. - 1,1 mm. Weight - 0,42 Kg. Basic dynamic load rating (C) - 19,9 kN. Basic static load rating (C0) - 6,95 kN. Fatigue load limit (Pu) - 0,36. Reference speed - 18000 r/min. Limiting speed - 11000 r/min. Calculation factor (e) - 0,22. Calculation factor (kr) - 0,04. Calculation factor (Y0) - 2,8. Calculation factor (Y1) - 2,9. Calculation factor (Y2) - 4,5. ...
d - 12 mm. D - 37 mm. B - 12 mm. C - 12 mm. d2 - 20 mm. r1 min. - 1 mm. r2 min. - 1 mm. D1 - 30,8 mm. da min. - 17,6 mm. Da max. - 31,4 mm. ra max. - 1 mm. Weight - 0,067 Kg. Basic dynamic load rating (C) - 9,36 kN. Basic static load rating (C0) - 2,16 kN. Fatigue load limit (Pu) - 0,12. Reference speed - 40000 r/min. Limiting speed - 28000 r/min. Calculation factor (e) - 0,35. Calculation factor (kr) - 0,04. Calculation factor (Y0) - 1,8. Calculation factor (Y1) - 1,8. Calculation factor (Y2) - 2,8. ...
FIG. 4. Effect of site-specific mutations on C/EBP and NF-Y binding activity. Nuclear extracts were prepared from 293T cells overexpressing C/EBP-α or -β. For mock, the cells were transfected by pcDNA. All probes were generated by PCR with 32P-labeled antisense primer and unlabeled sense primers using site-directed mutated plasmids as templates, and purified from the polyacrylamide gel, to equalize the specific activities between probes. A: DNA oligonucleotide sequence of wild and mutated probes used in EMSA. Mutated regions are indicated by lowercase with * with their name. B: EMSA using nuclear extracts of 293T cells overexpression C/EBP-α and C/EBP-β. Wild-type (wt) and mutant (m1, m2, m3, m4, and m5) probes were incubated with 4 μg of indicated nuclear extracts. The bands corresponding to NF-Y, C/EBP-α, and C/EBP-β are marked by arrows. C: Western blot (WB) analysis of C/EBP-α and -β for validating the expression of C/EBP-α and -β. 293T cells were transfected with expression ...
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We previously identified proline-rich protein 11 (PRR11) as a novel cancer-related gene that is implicated in the regulation of cell cycle and tumorigenesis. Our recent study demonstrated that PRR11 and its adjacent gene, kinetochore associated 2 (SKA2), constitute a classic head-to-head gene pair that is coordinately regulated by nuclear factor Y (NF-Y). In the present study, we further show that the PRR11-SKA2 bidirectional transcription unit is an indirect target of the tumor suppressor p53. A luciferase reporter assay revealed that overexpression of wild type p53, but not mutant p53, significantly represses the basal activity and NF-Y mediated transactivation of the PRR11-SKA2 bidirectional promoter ...
Plasmid pTBRII / CEP-Zeo / Hygro from Dr. Bert Vogelsteins lab contains the insert TGF beta type II receptor and is published in Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2412-6. This plasmid is available through Addgene.
Ameerika autospordisari NASCAR on sattunud järjekordse skandaali keskmesse, kui sarja ainsa mustanahalise sõitja Bubba Wallacei garaažist leiti pühapäeval silmus.
TY - JOUR. T1 - NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. AU - Murai-Takeda, Ayano. AU - Shibata, Hirotaka. AU - Kurihara, Isao. AU - Kobayashi, Sakiko. AU - Yokota, Kenichi. AU - Suda, Noriko. AU - Mitsuishi, Yuko. AU - Jo, Rie. AU - Kitagawa, Hirochika. AU - Kato, Shigeaki. AU - Saruta, Takao. AU - Itoh, Hiroshi. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2010/3/12. Y1 - 2010/3/12. N2 - The role of aldosterone has been implicated in the metabolic syndrome and cardiovascular diseases. The biological actions of aldosterone are mediated through mineralocorticoid receptor (MR). Nuclear receptor-mediated gene expression is regulated by dynamic and coordinated recruitment of coactivators and corepressors. To identify new coregulators of the MR, full-length MR was used as bait in yeast two-hybrid screening. Weisolated NF-YC, one of the subunits of heterotrimeric transcription factor NF-Y. Specific interaction between MRand NF-YC was ...
Zwijsen A., Goumans M.J., Lawson K.A., Van Rooijen M.A., Mummery C.L.. Transforming growth factor beta (TGFbeta) regulates the cell cycle and extracellular matrix (ECM) deposition of many cells in vitro. We have analysed chimaeric mouse embryos generated from embryonic stem cells with abnormal receptor expression to study the effect of TGFbeta on these processes in vivo and the consequences for normal development. The binding receptor for TGFbeta, TbetaRII, is first detected in the embryo proper around day 8.5 in the heart. Ectopic expression of TbetaRII from the blastocyst stage onward resulted in an embryonic lethal around 9.5 dpc. Analysis of earlier stages revealed that the primitive streak of TbetaRII chimaeras failed to elongate. Furthermore, although cells passed through the streak and initially formed mesoderm, they tended to accumulate within the streak. These defects temporally and spatially paralleled the expression of the TGFbeta type I receptor, which is first expressed in the node ...
Cytokine signal transduction is essential for normal immune function and controls the quality of responses to a wide variety of microbial infections. Innate and adaptive host responses to virus infections are regulated by autocrine and paracrine cytokine signaling systems. For most cytokines, receptor binding triggers an intracellular signaling cascade involving one or more signal transducer and activator of transcription (STAT) proteins. Diverse cytokine and growth factor signaling pathways produce active STAT transcription factors that specify mRNA induction profiles (26). For example, the alpha and beta interferon (IFN-α/β) family is of primary importance for both innate and adaptive antiviral immunity (reviewed in references 1, 49, and 53). In the innate antiviral system, IFN-α/β initiates a receptor-mediated signaling system that produces an activated STAT1-STAT2-IRF9 heterotrimeric transcription complex known as ISGF3 (27). The ISGF3 complex translocates to the nucleus, where it can ...
Ubiquitous Illin Ness Pdf Download Ubiquitous Illin Ness Pdf Download. Hey Guys, heres my fancy new solo called Ubiquitous Illin-ness from the new tapspace book Violent Tenor Cream played with my new Vic Firth Billy Club .. Landscape Performance Theory, an Introduction No matter how sophisticated you may be, .. NESS . do not have exact Informa tlon ag to the extent of the gamblin . ILLINI HALL May Made Begins Where Your Student Days Ended We are in harmony, .. What IKEA Tells Us About the Business Model of Law Practice . ness and was surprised at the .. Real-time spectrum analysis is used to predict and analyze . Ubiquitous (thank you, Dick .. A METASTABLE AUSTENITE WI!m PLANE STRESS FRACTURE TOUGH-NESS NEAR 500,000 . Download PDF to View . Ubiquitous Low-Cost Functionalized Multi-Walled Carbon .. Infrastructure Awareness . in ubiquitous computing systems in terms of accuracy and . ness model and a design space for Infrastructure Awareness.. The ubiquitous transcription factor NF-Y ...
configure --prefix=/usr --exec-prefix=/usr --bindir=/usr/bin --sbindir=/usr/sbin --sysconfdir=/etc --datadir=/usr/share --includedir=/usr/include --libdir=/usr/lib64 --libexecdir=/usr/libexec --sharedstatedir=/var/lib --mandir=/usr/share/man --infodir=/usr/share/info --build=x86_64-redhat-linux-gnu --host=x86_64-redhat-linux-gnu --target=x86_64-redhat-linux-gnu --program-prefix= --prefix=/opt/alt/php70 --exec-prefix=/opt/alt/php70 --bindir=/opt/alt/php70/usr/bin --sbindir=/opt/alt/php70/usr/sbin --sysconfdir=/opt/alt/php70/etc --datadir=/opt/alt/php70/usr/share --includedir=/opt/alt/php70/usr/include --libdir=/opt/alt/php70/usr/lib64 --libexecdir=/opt/alt/php70/usr/libexec --localstatedir=/var --with-curl=/opt/alt/curlssl/usr --sharedstatedir=/usr/com --mandir=/opt/alt/php70/usr/share/man --infodir=/opt/alt/php70/usr/share/info --cache-file=../config.cache --with-libdir=lib64 --with-config-file-path=/opt/alt/php70/etc ...
注意: PHP 5 では、foreachの実行開始時に内部配列ポインタは、 配列の先頭要素を指すように自動的にリセットされます。 このため、foreachループの前に reset()をコールする必要はありません。 PHP 5 では、foreach は内部の配列ポインタに依存するので、 ループ内で配列ポインタを変更すると予期せぬ振る舞いを引き起こします。 PHP 7 では、foreach は内部の配列ポインタを使わなくなりました。 ...
Я так понимаю, что для редактирования вывода стандартной галереи, нужно в файле functions.php темы отключить шорткод вывода remove_shortcode(gallery);
The biosynthesis of the beta-lactam antibiotic penicillin in the filamentous fungus Aspergillus nidulans is catalyzed by three enzymes that are encoded by the acvA, ipnA, and aatA genes. A variety of cis-acting DNA elements and regulatory factors form a complex regulatory network controlling these beta-lactam biosynthesis genes. Regulators involved include the CCAAT-binding complex AnCF and AnBH1. AnBH1 acts as a repressor of the penicillin biosynthesis gene aatA. Until now, however, little information has been available on the signal transduction cascades leading to the transcription factors. Here we show that inhibition of protein kinase C (Pkc) activity in A. nidulans led to cytoplasmic localization of an AnBH1-enhanced green fluorescent protein (EGFP) fusion protein. Computer analysis of the genome and screening of an A. nidulans gene library revealed that the fungus possesses two putative Pkc-encoding genes, which we designated pkcA and pkcB. Only PkcA showed all the characteristic features ...
Transcription is a process finely regulated by different transcription factors (TFs) which bind regulatory sequences present in gene promoters and allow the precise execution of gene expression programs. Misregulation of such process can lead to different pathologies, including development/differentiation defects, uncontrolled cell growth and cancer. For these reasons it is important to understand the molecular details of the interplay that occurs between different TFs to modulate gene expression. NF-Y, the heterotrimeric complex composed by NF-YA, NF-YB and NF-YC subunits, all required for DNA binding, recognizes the consensus sequence CCAAT, present in about 30% of eukaryotic promoters, at -60/-100 bp from the Transcription Start Site (TSS). One of the most important roles of NF-Y in transcription is to interact synergistically with other TFs to activate, or to repress, gene expression. In this study we focused on the relationship occurring between NF-Y and the TFs MAX, Myc and USF1, which ...
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Expression of NFYA (CBF-B, HAP2, NF-YA) in breast tissue. Antibody staining with HPA050779 and CAB009250 in immunohistochemistry.
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on top of the functions.php file, but that does not seem to give my functions access to the variable in settings.php. I need to put require(settings.php) in every function separately.. Is there a way I can declare the variables in settings.php to be accessible globally to all functions defined in functions.php?. Thank you,. ...
Некоторые проблемы возникают чаще других. Наиболее часто встречающиеся из них перечислены в разделе PHP FAQ этого руководства. ...
TY - JOUR. T1 - Association of the porcine transforming growth factor beta type i receptor (TGFBR1) gene with growth and carcass traits. AU - Chen, Kefei. AU - Hawken, Rachel. AU - Flickinger, Gail H.. AU - Rodriguez-Zas, Sandra L.. AU - Rund, Laurie A.. AU - Wheeler, Matthew B.. AU - Abrahamsen, Mitch. AU - Rutherford, Mark S. AU - Beever, Jonathan E.. AU - Schook, Lawrence B.. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Background: Growth and carcass traits are of great economic importance in livestock production. A large number of quantitative trait loci (QTL) have been identified for growth and carcass traits on porcine chromosome one (SSC1). A key positional candidate for this chromosomal region is TGFBR1 (transforming growth factor beta type I receptor). This gene plays a key role in inherited disorders at cardiovascular, craniofacial, neurocognitive, and skeletal development in mammals. Results: In this study, 27 polymorphic SNPs in the porcine TGFBR1 gene were identified on the University of ...
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Peaminister külastas reservväelaste õppust Okas 2017. Valitsus kutsus lisaõppekogunemise kokku kolmapäeval, 6.12, välja kutsuti reservväelased 669 ametikoha täitmiseks. Neljapäeval, 7.12 alanud õppus Okas 2017 kestab pühapäeva õhtuni. Tegu on teise korraga, kui Eesti oma reaalset kaitsevõimet sellisel kombel testib. Esimene lisaõppekogunemine toimus 2016. aasta detsembris, mil teenistusse kutsuti üle 300 reservväelase ja kaitseliitlase Põhja- ning Lõuna-Eestis. Video: Kaitsevägi ...
d - 31.75 mm. D - 68,262 mm. T - 22,225 mm. B - 22,225 mm. C - 17,462 mm. R - 3,6 mm. r - 1,5 mm. a - -5,1 mm. Da - 63 mm. db - 44,5 mm. da - 38,5 mm. Db - 59 mm. Aa - 1,2 mm. Ab - 0,9 mm. Weight - 0,37 Kg. Basic static load rating (C0) - 70,2 kN. Factor (G1) - 17,5. Factor (G2) - 8,5. Factor (Cg) - 0,0164. Factor (K) - 1,4. Basic dynamic load rating (C90) - 15,3. Basic dynamic load rating (Ca90) - 10,9. Basic dynamic load rating (C1) - 59,1 kN. Calculation factor (e) - 0,42. Calculation factor (Y) - 1,44. ...
Is PHP pass by reference or pass by value? Answer: PHP is pass by value, see the code below: |?php class Dog { public $name; public
TY - JOUR. T1 - Under pressure. T2 - Acute cardiac tamponade. AU - Chen, Leon. PY - 2019/5/1. Y1 - 2019/5/1. UR - http://www.scopus.com/inward/record.url?scp=85065026074&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85065026074&partnerID=8YFLogxK. U2 - 10.1097/01.CCN.0000553086.79399.f0. DO - 10.1097/01.CCN.0000553086.79399.f0. M3 - Article. AN - SCOPUS:85065026074. VL - 14. SP - 35. EP - 37. JO - Nursing Critical Care. JF - Nursing Critical Care. SN - 1558-447X. IS - 3. ER - ...
I have main site to which i put code using require function, but when i add php functions into it, they appear as plain text. The php code is rather long so i wont paste it here. Could anyone help me with that?. Thanks ok i am adding some code:. require part with only one function:. ...
I didnt realise, but ​Quercus is a PHP Implementation in Java, so its not a PHP 5.2 thing. If it was a PHP5.2 issue, Id expect many more broken sites, as every admin view would be fataling. Not sure it needs a backport, but doesnt do any harm either. Ill leave it up to nacin to decide what to do there ...
This article is basically helpfull in handling Registry Key through PHP code.; Author: amitjha1611; Updated: 10 Jul 2012; Section: PHP; Chapter: Web Development; Updated: 10 Jul 2012
13 milyon üzerinde projeye sahip dünyanın en büyük serbest çalışma pazarında Php output excel utf8 ile ilgili işler arayın ya da iş verin. Kaydolmak ve işlere teklif vermek ücretsizdir.
ได้โดยที่จะทำให้คุณนั้นสามารถสร้างกำไรจากการเล่นเกมส์เดิมพันออนไลน์ได้เราแนะนำเกมส์ชนิดนี้ให้คุณได้รู้จักก็เพราะว่าเชื่อว่าทุกคนนั้นจะต้องรู้วิธีการเล่นและวิธีการเอาชนะเกมม สล็อต ...
We have isolated a cDNA coding for a novel human protein that we called ICBP90, because it is an Inverted CCAAT box Binding Protein with a calculated size of 89,758 Da. Immunostaining experiments demonstrate that endogenous and overexpressed ICBP90 are located in the nucleus of HeLa and COS-1 cells, respectively. This is consistent with the presence of two potential nuclear localization signals found in the deduced ICBP90 amino acid sequence. No significant homology, except for the PHD finger (Fig. 3) ⇓ and the ubiquitin-like domain, was found with other proteins, some of which are known to be transcription factors. This suggests that ICBP90 may be a member of a new family of nuclear proteins with DNA-binding properties. Consistent with such an idea, recently, a mouse nuclear protein of 781 amino acids (Np95) was sequenced (39) . Np95 shows a 73.7% identity with ICBP90, which is not sufficient to conclude that Np95 is the mouse counterpart of ICBP90. Indeed, differences exist between these two ...
Epithelial ovarian cancer (EOC) makes up about probably the most gynecological malignancy-associated deaths in america. theres a positive correlation Mestranol between expression of EZH2 and NF-YA in EOCs. Large NF-YA expression predicts shorter general survival in EOC individuals Notably. The association of NF-YA using the promoter from the human being gene can be enhanced in […]. ...
etc/php.d/01-ioncube-loader.ini, /etc/php.d/20-bz2.ini, /etc/php.d/20-calendar.ini, /etc/php.d/20-ctype.ini, /etc/php.d/20-curl.ini, /etc/php.d/20-dom.ini, /etc/php.d/20-exif.ini, /etc/php.d/20-fileinfo.ini, /etc/php.d/20-ftp.ini, /etc/php.d/20-gd.ini, /etc/php.d/20-gettext.ini, /etc/php.d/20-gmp.ini, /etc/php.d/20-iconv.ini, /etc/php.d/20-imap.ini, /etc/php.d/20-mbstring.ini, /etc/php.d/20-mcrypt.ini, /etc/php.d/20-mysqlnd.ini, /etc/php.d/20-pdo.ini, /etc/php.d/20-phar.ini, /etc/php.d/20-posix.ini, /etc/php.d/20-shmop.ini, /etc/php.d/20-simplexml.ini, /etc/php.d/20-soap.ini, /etc/php.d/20-sockets.ini, /etc/php.d/20-sqlite3.ini, /etc/php.d/20-sysvmsg.ini, /etc/php.d/20-sysvsem.ini, /etc/php.d/20-sysvshm.ini, /etc/php.d/20-tidy.ini, /etc/php.d/20-tokenizer.ini, /etc/php.d/20-xml.ini, /etc/php.d/20-xmlwriter.ini, /etc/php.d/20-xsl.ini, /etc/php.d/20-zip.ini, /etc/php.d/30-mysql.ini, /etc/php.d/30-mysqli.ini, /etc/php.d/30-pdo_mysql.ini, /etc/php.d/30-pdo_sqlite.ini, /etc/php.d/30-wddx.ini, ...
php_installed=`dpkg -l , grep php, awk {print $2} ,tr \n ` # remove all php packge sudo aptitude purge `dpkg -l , grep php, awk {print $2} ,tr \n ` # use karmic for php pakage # pin-params: a (archive), c (components), v (version), o (origin) and l (label). echo -e Package: php5\nPin: release a=karmic\nPin-Priority: 991\n , sudo tee /etc/apt/preferences.d/php , /dev/null apt-cache search php5-,grep php5-,awk {print Package:, $1,\nPin: release a=karmic\nPin-Priority: 991\n},sudo tee -a /etc/apt/preferences.d/php , /dev/null apt-cache search -n libapache2-mod-php5 ,awk {print Package:, $1,\nPin: release a=karmic\nPin-Priority: 991\n}, sudo tee -a /etc/apt/preferences.d/php , /dev/null echo -e Package: php-pear\nPin: release a=karmic\nPin-Priority: 991\n , sudo tee -a /etc/apt/preferences.d/php , /dev/null # add karmic to source list egrep (main restricted,universe,multiverse) /etc/apt/sources.list,grep -v #, sed s/lucid/karmic/g , sudo tee ...
Hi, Ive seen some real potential for using Dependency Injection, but all of the code I work with is PHP4 only. So, I thought Id see if I could make something work in PHP4. The PHP5 features used by dependency injectors seem to be: interfaces type hints in constructor signature
Hi, Ive seen some real potential for using Dependency Injection, but all of the code I work with is PHP4 only. So, I thought Id see if I could make something work in PHP4. The PHP5 features used by dependency injectors seem to be: interfaces type hints in constructor signature
Answer to the Race Conditions with Ajax and PHP Sessions, AJAX Locking is a PHP class which can be used to lock server side resources to prevent race conditions that may occur when two users want to access the same
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Please note the internal behaviour of PHP that seems to do the reference assignment BEFORE actually copying the variable!!! Thus you get an array containing a (different) recursive array for the last testcase, instead of an array containing an empty array as you could expect ...
I just pruchased CS5 and am trying to view and modify a php file in Split view. The Split. Design and Love Codebuttonds are greted out. I tried
These proteins are known as CCAAT box binding proteins/CCAAT box binding factors. A CCAAT box is a feature frequently found ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ... "DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y". The Journal of Biological Chemistry. 272 (42): 26562-26572. doi: ... Another aspect of the CCAAT binding motif is the CCAAT/enhancer binding proteins (C/EBPs). They are a group of transcription ...
"Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, ... gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression ... for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66-73. doi:10.1006/geno.1995.1107. PMID 7590749 ... Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates ...
Mantovani R (October 1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15-27. doi:10.1016/S0378- ... forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. ... chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor". The Journal of ... "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Research. 20 (5): 1087-91. doi:10.1093/ ...
Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15-27. doi:10.1016/S0378-1119(99) ... forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a ... "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Res. 20 (5): 1087-91. doi:10.1093/nar/ ... "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300". J. Biol. Chem. 274 (12): 7623 ...
"Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)". Blau J, Xiao H, McCracken S, et al. (1996). "Three ... Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and ... for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66-73. doi:10.1006/geno.1995.1107. PMID 7590749 ... Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene. GRCh38: Ensembl release 89: ENSG00000141905 - ...
These transcription factors include MAX binding protein and Estrogen-related receptor alpha (secondary DNA binding preference) ... "CEBPE CCAAT/enhancer binding protein epsilon [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-09 ... The transcription factors that act on C8orf48 are presented in Table 1. The majority of the transcription factors are involved ... "E2F1 E2F transcription factor 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-09. "KLF7 ...
Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/ ... Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15-27. doi:10.1016/S0378-1119(99) ... Martinelli R, Heintz N (1994). "H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor ... "The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y". J. Biol. Chem. 278 ...
Serum response factor, SMARCA2, Sp1 transcription factor, TRIM28, and Zif268. Ccaat-enhancer-binding proteins GRCh38: Ensembl ... Chen GK, Sale S, Tan T, Ermoian RP, Sikic BI (April 2004). "CCAAT/enhancer-binding protein beta (nuclear factor for interleukin ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ... "Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins". Mol. Cell. ...
It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. The protein functions ... eukaryotic initiation factor 2α (eIF2α), and induction of a transcription factor, activation transcription factor 4 (ATF4), ... Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D (April 1996). "Stress-induced binding of the transcriptional factor CHOP ... CHOP also interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 ...
CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Ccaat-enhancer-binding proteins ... Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site". J. ... CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene. The C/EBP family of ... "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma". Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine- ...
"Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/ ... "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". ... CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene. The protein encoded by this ... "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb ...
... and Ccaat/enchancer binding proteins. Experimental data reveals that FAM63A expression decreases when the estrogen receptor is ... The promoter region contains a number of transcription factors. Those with high scores include estrogen response elements, TATA ... Promoter and transcription factors for FAM63A. http://www.genomatix.de/?s=23e6b2edc9ca33fe998f299bafe56b99 Estrogen receptor ...
Other proteins such as interferon regulatory factor-2-binding protein-1 (IRF2BP1). CCAAT/enhancer-binding protein gamma (C/EBPγ ... It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF- ... and recruits interferon regulatory factor 2 binding protein 1 (IRF2BP1), which acts as an E3 ligase. Phosphorylation of Thr at ... "The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and ...
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". ... "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain ... This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The ... "The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, ...
... transcription is regulated by the binding of many transcription factors to the promoter region. The CCAAT binding protein ... Several of the transcription factors including EH1, NACA, NKX5-2, SIX4, VCR, etc. are involved in developmental pathways. Most ...
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". Mol ... HNF-3G is a member of the forkheadclass of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... 2009). "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ...
IL-6 activates the CCAAT enhancer-binding protein transcription factors which activate MDR1 gene expression (see Alteration of ... MDR1 is activated through NF-κB, a protein complex which acts as a transcription factor. In the rat, an NF-κB binding site is ... Growth factor expression levels can also promote resistance to antineoplastic therapies. In breast cancer, drug resistant cells ... This transporter protein is encoded by the MDR1 gene and is also called the ATP-binding cassette (ABC) protein. MDR1 has ...
Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2)". J. Biol. Chem. 276 (49): 45780-90. doi: ... the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ...
Transcription factors, peroxis proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding proteins (C/EBPs) are main ... T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), GATA2/3, retinoic acid receptor α, and SMAD6/7 don't affect the ... Other pro-adipogenic factors like C/EBPs and Krüppel-like factors (KLFs) have been shown to induce the PPARγ promoter. Moreover ... Adipocyte determination and differentiation factor 1 (ADD1) and sterol regulatory element binding protein 1 (SREBP1) can ...
"U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y". ... dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA ... The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future ... Jaeger S, Martin F, Rudinger-Thirion J, Giegé R, Eriani G (2006). "Binding of human SLBP on the 3'-UTR of histone precursor H4- ...
... granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding ... CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. ... "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul ... The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions ...
No vertebrate TATA binding protein factors, RNA polymerase transcription factor II B, CCAAT binding factors, or CCAAT enhancer ... The transcription factors with the highest matrix scores include NKX homeodomain factors, GATA-binding factors, two-handed zinc ... Various transcription factors are predicted to bind within the conserved parts of the promoter (upstream regulatory) region, on ... finger, E2F transcription factor, and T-box transcription factors. ...
CCAAT/enhancer-binding protein epsilon) gene, a transcription factor primarily active in myeloid cells. Almost all patients ... granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding ... Khanna-Gupta A, Sun H, Zibello T, Lee HM, Dahl R, Boxer LA, Berliner N (2007). "Growth factor independence-1 (Gfi-1) plays a ...
Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/ ...
Barberis A, Superti-Furga G, and Busslinger M. "Mutually exclusive interaction of the CCAAT-binding factor and of a ... In mammals, a CCAAT-displacement activity was originally described in DNA binding assays. The human gene was identified ... "Sequence-specific DNA binding of individual Cut repeats of the human CCAAT displacement/Cut homeodomain protein". Proceedings ... Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2)". Journal of Biological Chemistry 2001, ...
"Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper ... Hai T, Curran T (May 1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding ... This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein ... cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper ...
2003). "The transcription factor CCAAT-binding factor CBF/NF-Y regulates the proximal promoter activity in the human alpha 1(XI ...
... is transcription factor CCAAT-enhancer binding protein α (C/EBPα). Mutations in C/EBPα are associated with acute myeloid ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c- ... Other factors, termed colony-stimulating factors (CSFs), specifically stimulate the production of committed cells. Three CSFs ...
"G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta". The Journal of Biological ... For example, G9A/GLP can methylate a number of transcription factors to regulate their transcriptional activity, including MyoD ... Therefore, the G9A/GLP complex can both methylate histone tails and bind to mono- and di-methylated H3K9 to recruit molecules, ... Nair SS, Li DQ, Kumar R (February 2013). "A core chromatin remodeling factor instructs global chromatin signaling through ...
kinase binding. • GO:0001948 protein binding. • GO:0000975 transcription regulatory region DNA binding. • transcription factor ... CEBPA, C/EBP-alpha, CEBP, CCAAT/enhancer binding protein alpha, CCAAT enhancer binding protein alpha. ... transcription factor binding. • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding. • ... RNA polymerase I regulatory region DNA binding. • DNA binding. • sequence-specific DNA binding. • protein homodimerization ...
In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... CCAAT boxes are common, as they are in many promoters that lack TATA boxes. In addition, the motifs NRF-1, GABPA, YY1, and ... An example is the E-box (sequence CACGTG), which binds transcription factors in the basic helix-loop-helix (bHLH) family (e.g. ... The process is more complicated, and at least seven different factors are necessary for the binding of an RNA polymerase II to ...
transcription factor binding. • RNA polymerase II activating transcription factor binding. • phosphoprotein binding. • kinase ... "Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled ... protein binding. • androgen receptor binding. • identical protein binding. • enzyme binding. • ubiquitin protein ligase binding ... DNA binding. • core promoter binding. • transcription factor activity, sequence-specific DNA binding. • transcription ...
"CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J ... identify dynamic changes in the phosphorylation status of more than 6000 sites after stimulation with epidermal growth factor.[ ... The phosphorylation of glucose can be enhanced by the binding of Fructose-6-phosphate, and lessened by the binding fructose-1- ... Antibodies bind to and detect phosphorylation-induced conformational changes in the protein. Such antibodies are called phospho ...
Some transcription factors, so-called pioneering factors are still able to bind their DNA binding sites on the nucleosomal DNA ... I. constitutively active - present in all cells at all times - general transcription factors, Sp1, NF1, CCAAT ... The DNA sequence that a transcription factor binds to is called a transcription factor-binding site or response element.[55] ... Main article: DNA-binding domain. The portion (domain) of the transcription factor that binds DNA is called its DNA-binding ...
... implication of factor binding in elevated fetal globin expression". Nucleic Acids Res. 18 (17): 5245-53. doi:10.1093/nar/18.17. ... 1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box ... oxygen binding. • heme binding. • metal ion binding. • oxygen transporter activity. • peroxidase activity. • protein binding. • ... haptoglobin binding. • organic acid binding. Cellular component. • hemoglobin complex. • cytosol. • haptoglobin-hemoglobin ...
transcription factor binding. • sequence-specific DNA binding. Cydrannau o'r gell. • CCAAT-binding factor complex. • protein- ... "Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. ". Gene. 1997. PMID ... GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity. • GO:0000980 RNA polymerase II cis- ... GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • ...
March 2001). "Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute ... such as the SRY gene for testis determining factor. Dominance rules for sex-linked gene loci are determined by their behavior ... The enzyme coded for by IA adds an N-acetylgalactosamine to the membrane-bound H antigen. The IB enzyme adds a galactose. The i ... Dominant negative mutations of the transcription factor C/EBPα can cause acute myeloid leukemia.[20] Inherited dominant ...
Sterneck began to study the functions of CCAAT-enhancer-binding proteins (C/EBP) transcription factors, including their roles ... Esta Sterneck is an Austrian molecular biologist researching the functions of the C/EBPδ][CEBPD transcription factor as tumor ... oncogene cooperation in leukemia cells and revealed their coordinate induction of an essential autocrine growth factor. Her ...
Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the ... "Entrez Gene: PIR pirin (iron-binding nuclear protein)". Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; ... 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): ... 2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor". J. Biol. Chem. 279 (2): ...
However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... Boruk M, Savory JG, Haché RJ (November 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated ... DNA-binding domain (DBD) D - hinge region E - ligand-binding domain (LBD) F - C-terminal domain In the absence of hormone, the ... "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the ...
Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid ... these tyrosine motifs are bound by the SH2 domains of signaling proteins. Important binding partners for this region include ... Important binding partners for this region include FAK, PTK2B, C3G, PTP-PEST, PTP1B, CIZ, and FRNK. Central "substrate domain" ... All CAS proteins except CASS4 contain a YDYVHL motif within this domain, which is an important binding site for the Src SH2 ...
The activated transcription factor upregulates UPR 'stress genes' by directly binding to stress element promoters in the ... An important example is that the proapoptotic protein CHOP (CCAAT/-enhancer-binding protein homologous protein), is upregulated ... The activated domain is able to activate the transcription factor XBP1(Xbox binding protein) mRNA (the mammalian equivalent of ... ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ...
Transcription factor assessment indicates many potential TATA-binding protein and CCAAT-enhancer-binding proteins sites, along ... promoter analysis based on transcription factor binding sites". Bioinformatics. 21 (13): 2933-42. doi:10.1093/bioinformatics/ ... Ligand binding sites are predicted by I-TASSER from positions 377 to 530 in Isoform X1. A leucine zipper motif is present in ... indicating that this segment may be aqueous and tightly bound. This mixed charge cluster is only partially conserved across ...
Zuo Y, Qiang L, Farmer SR (March 2006). "Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta ... targeting the transcription factor brain-derived neurotrophic factor (BDNF) and ultimately reducing its expression. BDNF plays ... Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the ... and 222 significantly inhibited adipogenesis and repressed induction of the master regulators PPARγ and CCAAT/enhancer-binding ...
CCAAT binding factors, HOX-PBX complexes, and C2HC zinc finger transcription factors 13. The SRY gene is the primary factor in ... PROSER2 interacts most strongly with the following transcription factors: Vertebrate TATA binding protein factor, ZF5 POZ ... Although PROSER2's function in humans has not been elucidated, its SARG domain, interacting proteins/transcription factors, and ... with androgens would be controlled by transcription factors in the SOX/SRY-sex/testis determining and related HMG box factors ...
"CCAAT/Enhancer-binding Protein Family Members Recruit the Coactivator CREB-binding Protein and Trigger Its Phosphorylation". ... PMID 26769965.CS1 maint: multiple names: authors list (link) "IGFALS insulin like growth factor binding protein acid labile ... PMID 12857754.CS1 maint: multiple names: authors list (link) Ramji D.P., Foka P. (2002). "CCAAT/enhancer-binding proteins: ... "TATA-binding proteins". InterPro. Retrieved 6 May 2019. "SRY Gene". Genetics Home Reference. Vihervaara A, Sistonen L (2014). " ...
... which contains recognition motifs for binding transcriptional regulatory factors such as Sp1, activator protein 1 and 2, CCAAT ... and two myocyte-specific enhancer-binding factor 1 boxes. Upstream of the first exon lies a TATA-like box and CpG-rich region, ... TFG-TEC binds to the proximal promoter region of the ENO3 gene. Click on genes, proteins and metabolites below to link to ... This first intron, along with the 5'-flanking region, contains a consensus sequence for muscle-specific regulatory factors that ...
"A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy ... Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1. GRCh38: Ensembl release 89: ENSG00000105229 ... Lee PS, Chang C, Liu D, Derynck R (2003). "Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta ... 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J ...
... regulating gene involved in regulation of fatty acid storage and glucose metabolism and members of the CCAAT/enhancer-binding ... of the gene expression is important as they can be indicative of various health issues such as obesity related risk factors ... which are exported into the blood and bound to albumin, and glycerol, which is exported into the blood freely. There is ... protein (C/EBP) family, type of transcription factors that promotes gene expression.PPARγ is required for both the adipogenesis ...
"The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to ...
... several copies of the binding site for the Sp1 transcription factor and the absence of TATA-box and CCAAT-box motifs typically ...
Twist Subfamily of Class B bHLH Transcription Factors (HAND) CCAAT/Enhance Binding Protein (CEBP) Nuclear Factor of Activated T ... Notable transcription factors that bind CCDC109B include: Fork Head Domain Factors (FKHD) Myeloid Zinc Finger 1 Factors (MZF1) ... CCDC109B has a promoter region that contains sites for transcription factor binding. This promoter region is approximately 500 ... Pleomorphic Adenoma Gene (PLAG) C2H2 Zinc Finger Transcription Factors 2 (ZF02) Vertebrate SMAD Family of Transcription Factors ...
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a ... Nuclear factor I/CCAAT box transcription factor trans-activating domain is a negative sensor of cellular stress. Morel, Y., ... Promoter region of the human gene coding for beta-chain of C4b binding protein. Hepatocyte nuclear factor-3 and nuclear factor- ... Synonyms: CCAAT-box-binding transcription factor, CTF, CTF5, NF-I, NF-I/C, ... ...
CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue. ... CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue ... CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue ... CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue ...
... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ...
Nuclear Y/CCAAT-box binding factor B subunit NF-YBImported. ,p>Information which has been imported from another database using ... tr,O73744,O73744_XENLA Nuclear Y/CCAAT-box binding factor B subunit NF-YB OS=Xenopus laevis OX=8355 GN=nfyb PE=2 SV=1 ...
Effect of hypoxia on the expression of CCAAT/enhancer-binding protein β and receptor activator of nuclear factor kappa-B ligand ... In this study, the role of hypoxia-inducible factor-1 (HIF-1) signaling in the regulation of CCAAT (cytosine-cytosine-adenosine ... thymidine)/enhancer-binding protein-β (C/EBPβ) and the receptor activator of nuclear factor kappa-B ligand (RANKL) expressions ... macrophage migration inhibitory factor, monocyte chemoattractant protein-1, and macrophage colony-stimulating factor in the ...
SF (steroidogenic factor-1), C/EBPβ (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor ... Functional Cooperation of Simian Virus 40 Promoter Factor 1 and CCAAT/Enhancer-Binding Protein β and δ in Lipopolysaccharide- ... Functional Cooperation of Simian Virus 40 Promoter Factor 1 and CCAAT/Enhancer-Binding Protein β and δ in Lipopolysaccharide- ... Functional Cooperation of Simian Virus 40 Promoter Factor 1 and CCAAT/Enhancer-Binding Protein β and δ in Lipopolysaccharide- ...
... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ...
CCAAT-binding transcription factor); nuclear factor 1 X-type; NF1A; CCAAT box binding transcription factor; CCAAT-box-binding ... Nuclear factor 1 X type; Nuclear factor 1/X; Nuclear factor I/X; TGGCA binding protein; TGGCA-binding protein; nuclear factor I ... Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. ... transcription factor; CTF; NF-I/X; NF1-X; NF1X; NFI X; NFI-X; NFI/X; NFIX_HUMAN; ...
When we inserted multiple point mutations that mimic changes known to abolish binding of CCAAT-binding factor to CCAAT ... 201 harbors a copy of the sequence CCAAT that is identical to the binding site for the CCAAT-binding transcription factor (30 ... we inserted multiple point mutations that mimic changes known to abolish binding of the CCAAT-binding factor to CCAAT boxes (31 ... A Transcription Factor Cascade Involving Fep1 and the CCAAT-Binding Factor Php4 Regulates Gene Expression in Response to Iron ...
CCAAT/enhancer binding protein-β (C/EBPβ) and NF-E2-related factor-2 (Nrf2) are both involved in the regulation of the genes ... CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN ... CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN ... CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN ...
CCAAT/enhancer binding protein (C/EBP)ε, a member of the leucine zipper family of transcription factors, is expressed primarily ... CCAAT/enhancer binding proteins (C/EBPs) comprise a family of transcription factors that are key regulators of cellular ... Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT enhancer binding protein ε ... Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT enhancer binding protein ε ...
RecName: Full=CCAAT/enhancer-binding protein delta; Short=C/EBP delta; AltName: Full=Nuclear factor NF-IL6-beta; Short=NF-IL6- ... RecName: Full=CCAAT/enhancer-binding protein delta; Short=C/EBP delta; AltName: ... RecName: Full=CCAAT/enhancer-binding ... The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA ... HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver ...
Characterization of a teleost insulin-like growth factor II (IGF-II) gene: Evidence for promoter CCAAT/enhancer-binding protein ... Characterization of a teleost insulin-like growth factor II (IGF-II) gene: Evidence for promoter CCAAT/enhancer-binding protein ... Characterization of a teleost insulin-like growth factor II (IGF-II) gene : Evidence for promoter CCAAT/enhancer-binding ... Here we describe a rainbow trout IGF-II gene with a proximal promoter that contains two CCAAT/enhancer-binding protein (C/EBP) ...
CCAAT-Binding Factor, A-Subunit. Known as: CCAAT Binding Factor, A Subunit, CCAAT-Binding CBF-A Protein, Protein, CCAAT-Binding ... The mammalian CCAAT-binding factor (CBF; also called NF-Y and CP1) is a heterotrimeric protein consisting of three subunits, ... Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA ... CArG box-binding factor-A (CBF-A) interacts with the penta-decamer (pd) element that is a conserved sequence element within ...
Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ...
... eukaryotic translation initiation factor (eIF4E), and 4E binding protein. ... Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients J ... Background: Bronchial smooth muscle (BSM) cells of asthmatic patients have an impaired expression of CCAAT/enhancer binding ... CCAAT-Enhancer-Binding Protein-alpha / biosynthesis* * CCAAT-Enhancer-Binding Protein-alpha / immunology ...
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402 ... the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). ... DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl. *DNA-binding transcription factor ... CCAAT/enhancer-binding protein deltaAdd BLAST. 268. Amino acid modifications. Feature key. Position(s). DescriptionActions. ...
CCAAT/Enhancer binding proteins (C/EBPs) play important roles in the regulation of cell growth and differentiation. This study ... Transcription Factors / genetics Substances * CCAAT-Enhancer-Binding Protein-beta * CCAAT-Enhancer-Binding Proteins ... CCAAT/Enhancer binding proteins (C/EBPs) play important roles in the regulation of cell growth and differentiation. This study ... Expression and function of CCAAT/enhancer binding proteinbeta (C/EBPbeta) LAP and LIP isoforms in mouse mammary gland, tumors ...
Regulation of transcription factors belonging to the CCAAT/enhancer binding protein (C/EBP) family. The C/EBP family plays a ... Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein ... The tumour necrosis factor-a-mediated suppression of the CCAAT/enhancer binding protein-a gene transcription in hepatocytes ... Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein ...
CDT1: chromatin licensing and DNA replication factor 1. *CEBPA: CCAAT enhancer binding protein alpha ...
CCAAT-box-binding transcription factor. NF-I/C. NF1-C. TGGCA-binding protein. nuclear factor I/C (CCAAT-binding transcription ... These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for ... DNA-binding transcription factor activity, RNA polymerase II-specific IBA Inferred from Biological aspect of Ancestor. more ... DNA-binding transcription factor activity, RNA polymerase II-specific ISA Inferred from Sequence Alignment. more info ...
... to tumor escape from host immune surveillance and to cancer progression by production of tumor-promoting soluble factors.... ... Basic fibroblast growth factor. C/EBPβ. CCAAT/enhancer-binding protein beta ... Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells ... Dale DC (2002) Colony-stimulating factors for the management of neutropenia in cancer patients. Drugs 62(Suppl 1):1-15CrossRef ...
NF-Y transcription factor binds to CCAAT boxes on promoters of cell cycle regulatory genes such as cdc2, cyclin B, cdc25C, and ... CCAAT-Binding Factor/metabolism , Cell Cycle , Cell Line, Tumor , Down-Regulation , HSP70 Heat-Shock Proteins/metabolism , ... CBF/HSP70 was originally identified as a transcription factor binding to the CCAAT box on the hsp70 promoter and mediates ... CCAAT-Binding Factor / Cell Line, Tumor Language: English Journal: Experimental & Molecular Medicine Year: 2005 Type: Article ...
CCAAT/enhancer binding protein zeta (mouse, aa620-633) Antibody (internal region), Peptide-affinity purified goat antibody ... CCAAT-binding factor; CCAAT-box-binding transcription factor; CCAAT/enhancer binding protein alpha (C/EBP) related sequence 1; ... AF3887a: CCAAT/enhancer binding protein zeta (mouse) Antibody (C-Term). AF3888a: CCAAT/enhancer binding protein zeta (mouse, ... CCAAT/enhancer binding protein zeta (mouse, aa620-633) Antibody (internal region) is for research use only and not for use in ...
The CCAAT-box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 ( ... The CCAAT-box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 ( ... and gel supershift assays demonstrated that the transcription factor NF-Y preferentially binds to the inverted CCAAT box at - ... Based on this analysis, a set of potential, putative transcription factor binding sites for Oct1, Sp1, Cp-1/NF-Y, CEBP, p40X, ...
Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide- ... Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide- ... title = "Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in ... Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide- ...
By cancercurehere with Comments Off on The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in ... The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction ... The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic. ... and among the main regulators may be the CCAAT enhancer binding proteins (C/EBP) family. Associates of the grouped family ...
Brain-derived neurotrophic factor. CEBPB. CCAAT enhancer binding protein β1. ERK1/2. Extracellular signal-regulated kinase ½ ... Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2015;11(6):1164-78.CrossRefPubMedPubMedCentral ... and brain-derived neurotrophic factor (BDNF), which is a neurotrophic factor, thereby offering protection against experimental ... De Santi L, Annunziata P, Sessa E, Bramanti P. Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune ...
Activating transcription factor-2. C/EBPβ:. CCAAT/enhancer binding protein beta. ... J. I. Jones and D. R. Clemmons, "Insulin-like growth factors and their binding proteins: biological actions," Endocrine Reviews ... R. Drakas, X. Tu, and R. Baserga, "Control of cell size through phosphorylation of upstream binding factor 1 by nuclear ... preventing binding of AP2-α to Sp1, as well as binding of Sp1 and C/EBPβ to their DNA consensus sites within the INSR gene ...
Activating transcription factor-6. CHOP:. CCAAT/enhancer-binding Homologous protein. GADD:. Growth arrest and DNA damage ... Chronic ER stress is emerging as a trigger that imbalances a number of systemic and arterial-wall factors and promote ... Clinical and experimental evidence indicates that inflammatory processes in the vascular wall are the decisive factor that ... Risk Factors and Prevention, pp. 164-172, Jaypee Brothers, Medical Publishers, New Delhi, India, 2006. View at Google Scholar ...
  • We also analyzed levels of proteins that control translation of CEBPA mRNA, namely heterogeneous nuclear ribonucleoprotein E2, calreticulin, eukaryotic translation initiation factor (eIF4E), and 4E binding protein. (nih.gov)
  • The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • CEBPA gene mutations that cause familial acute myeloid leukemia with mutated CEBPA result in a shorter version of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • The somatic CEBPA gene mutations identified in leukemia cells generally decrease the DNA-binding ability of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • Nuclear protein binding sites in the mouse adiponectin promoter. (diabetesjournals.org)
  • NF-Y and C/EBP are bound to the adiponectin promoter in vitro. (diabetesjournals.org)
  • Previous studies have revealed that LPS can activate transcription of the IL-10 gene promoter through an SV40 promoter factor 1 (Sp1) binding site in mouse macrophage RAW264.7. (jimmunol.org)
  • In the studies of LPS-induced gene expression of human IL-10, transcription factors STAT3 and SV40 promoter factor 1 (Sp1) 3 were reported to be essential in this regulation ( 20 , 21 ). (jimmunol.org)
  • In mouse monocytes/macrophages, the Sp1 binding site residing at −89 to −78 bp of the IL-10 promoter is also critical for its basal and LPS-induced expression ( 22 , 23 ). (jimmunol.org)
  • Here we describe a rainbow trout IGF-II gene with a proximal promoter that contains two CCAAT/enhancer-binding protein (C/EBP) binding sites (TCBS1 and TCBS2). (elsevier.com)
  • The kappa promoter penta-decamer binding protein CBF-A interacts specifically with nucleophosmin in the nucleus only. (semanticscholar.org)
  • CBF/HSP70 was originally identified as a transcription factor binding to the CCAAT box on the hsp70 promoter and mediates transcription repression of hsp70 pro- moter by p53. (bvsalud.org)
  • The 5' flanking proximal promoter region of the AKR1C1 gene consists of a TATA box and an inverted CCAAT binding site. (temple.edu)
  • A computational analysis utilizing the Alibaba 2.0 on the proximal AKR1C1 gene promoter region was performed to identify potential transcription factor binding sites. (temple.edu)
  • Based on this analysis, a set of potential, putative transcription factor binding sites for Oct1, Sp1, Cp-1/NF-Y, CEBP, p40X, USF, NF1 and AP-2 were identified in the region -180 to -88 of the AKR1C1 gene promoter. (temple.edu)
  • JNK activation increased C/ebpd mRNA and protein expression through the induction and phosphorylation of activating transcription factor 2 (ATF2) that binds to a responsive element within the C/ebpd gene promoter region. (biochemj.org)
  • GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding . (genecards.org)
  • TCM caused a 5.7-fold induction of the −517-bp promoter II construct, whereas site-directed mutagenesis of a CCAAT/enhancer binding protein (C/EBP) binding site (−317/−304 bp) abolished both baseline and TCM-induced activities. (aacrjournals.org)
  • In conclusion, malignant breast epithelial cells secrete factors, which induce aromatase expression in adipose fibroblasts via promoter II. (aacrjournals.org)
  • This is, at least in part, mediated by a TCM-induced up-regulation and enhanced binding of C/EBPβ to a promoter II regulatory element. (aacrjournals.org)
  • Full gene expression occurs when transcription activator proteins bind to each module within the regulatory promoter. (wikipedia.org)
  • the promoter lacks one of the two C residues from the pentameric motif, and the artificial addition of the second C has no significant effects on binding activity. (wikipedia.org)
  • In an experiment done with core binding factors (CBF) and DNA complexes, researchers were able to determine the preferential sequences of the promoter in a region over and immediately adjacent to the CAAT box, and two regions on either side of the CAAT box. (wikipedia.org)
  • In another experiment performed with the major late promoter (MLP) of adenoviruses from a variety of host species, it was shown that the mutation of the CAAT box and CCAAT sequence, which is thought to play a pivotal role in the (MLP) of subgroup C human adenoviruses, in species with a deficient CAAT sequence. (wikipedia.org)
  • The protein encoded by this gene is one subunit of a trimeric complex NF-Y, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. (wikipedia.org)
  • Subsequently, ATF4 co-occupies promoter regions of over 30 MYC-target genes, primarily those regulating amino acid and protein synthesis, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), a negative regulator of translation. (stanford.edu)
  • Some transcription factors (for example, cyclic AMP (cAMP) response element-binding protein (CREB)) function early in the programme of adipogenesis to regulate expression of C/EBP and PPAR, whereas others, such as GATA2/3 and SMAD3, physically interact with C/EBP to inhibit its transcriptional activity on the Pparg2 promoter. (nikas-culinaria.com)
  • Comparative genomics analyses revealed that the binding sites for PU.1, SP1/Krüppel-like, CCAAT-box, and TCF/LEF/SOX transcription factors were conserved among 5'-promoter regions of mammalian FZD7 orthologs. (ingentaconnect.com)
  • Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. (embl.de)
  • The serum response factor is a member of the MADS-box ( M CM1, A gamous, D eficiens, and S RF) box superfamily of transcription factors, [5] binding to the serum response element (SRE) in the promoter region of target genes. (wikiversity.org)
  • Sequence deletions from this construct revealed a hepatocyte nuclear factor 1 (HNF1) element (-2558), and mutation of this element reduced basal (75%) and MVA-induced (30%) reporter activity and attenuated promoter activation following overexpression of HNF1 α or 1 β . (aspetjournals.org)
  • NF-Y transcription factor binds to CCAAT boxes on promoters of cell cycle regulatory genes such as cdc2, cyclin B , cdc25C, and cyclin A . We previously reported that the DNA binding activity of NF-Y is regulated by p53-p21-cdk2 pathway. (bvsalud.org)
  • C/EBP proteins interact with the CCAAT ( cytidine -cytidine- adenosine -adenosine- thymidine ) box motif which is present in several gene promoters . (thefullwiki.org)
  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. (genecards.org)
  • It binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. (thermofisher.com)
  • C/EBP homologous protein, encoded by the DNA damage-inducible transcript 3 ( Ddit3 ) gene, is one of the six identified members of C/EBP trans-acting factors that bind to the CCAAT box motif present in several promoters. (frontiersin.org)
  • Experiments in many laboratories have shown that mutations to the CCAAT motif that cause a loss of CBF binding also decreases transcriptional activity in these promoters, suggesting that CBF-CCAAT complexes are essential for optimum transcriptional activity. (wikipedia.org)
  • nuclear factor I/C (CCAAT-binding. (wikigenes.org)
  • In this study, the role of hypoxia-inducible factor-1 (HIF-1) signaling in the regulation of CCAAT (cytosine-cytosine-adenosine-adenosine-thymidine)/enhancer-binding protein-β (C/EBPβ) and the receptor activator of nuclear factor kappa-B ligand (RANKL) expressions in immortalized human periodontal ligament (PDL) cells was investigated. (nii.ac.jp)
  • Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene. (asm.org)
  • Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. (creative-biogene.com)
  • In another study, we found that ceramide decreased nuclear hepatic nuclear factor-1 (HNF1), whose binding to the HNF1-response element in the GSTA2 gene was responsible for the constitutive and inducible gene expression. (aspetjournals.org)
  • Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro. (nih.gov)
  • Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines. (nih.gov)
  • Studies indicate the role of nuclear factor one (NFIs) as epigenetic regulators in cancer. (nih.gov)
  • Title: Nuclear factor one transcription factors as epigenetic regulators in cancer. (nih.gov)
  • NFIB (Nuclear Factor I B) is a Protein Coding gene. (genecards.org)
  • It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to bind to the CCAAT motif. (wikipedia.org)
  • Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene . (wikipedia.org)
  • A protein binding to CArG box motifs and to single-stranded DNA functions as a transcriptional repressor. (semanticscholar.org)
  • FZD7 orthologs were seven-transmembrane proteins with extracellular Frizzled domain, leucine zipper motif around the 5th transmembrane domain, and cytoplasmic DVL- and PDZ-binding motifs. (ingentaconnect.com)
  • However, compared with the massive knowledge about the transcriptome, we have surprisingly little knowledge about regulatory mechanisms underling transcriptomic diversity.Our analysis found that motifs bound by ELK1, E2F, NRF1 and NFY are potential regulatory motifs that positively correlate with malignant progression of breast cancer.The results suggest that these 4 motifs are principal regulatory motifs driving malignant progression of breast cancer. (nih.gov)
  • Our analysis found that motifs bound by ELK1, E2F, NRF1 and NFY are potential regulatory motifs that positively correlate with malignant progression of breast cancer. (nih.gov)
  • a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to mRNA is called a transcription factor . (wikiversity.org)
  • YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. (thermofisher.com)
  • This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. (thermofisher.com)
  • The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. (genecards.org)
  • Binds and stabilizes cytoplasmic mRNA. (genecards.org)
  • Furthermore, there is also evidence that BCR/ABL globally affects the efficiency of the basal mRNA translation machinery by regulating the mammalian target of rapamycin and S6 kinase pathways and the function of the translation factors eukaryotic translation initiation factor 4E and eukaryotic initiation factor 4E-binding protein 1 and ( 15 , 16 ). (aacrjournals.org)
  • The sequence alignment or the binding energy of miRNA/mRNA pairs can sometimes hold definitive information in screening target genes. (biomedcentral.com)
  • By gel shift assay and Western blotting, we found that the DNA binding complex and protein expression of C/EBPβ and δ were increased by LPS treatment, but these results were not found for Sp1. (jimmunol.org)
  • Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. (frontiersin.org)
  • Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream protein expression via gene regulation. (frontiersin.org)
  • Bronchial smooth muscle (BSM) cells of asthmatic patients have an impaired expression of CCAAT/enhancer binding protein (C/EBP) alpha, which is associated with increased proliferation. (nih.gov)
  • Specific focus is on understanding how key factors associated with inflammatory disorders, such as cytokines and lipid metabolites, regulate macrophage processes and gene expression during atherosclerosis and the acute-phase response. (cardiff.ac.uk)
  • In particular, we are elucidating the pathways leading from the interaction of such factors with their receptors, through the signalling cascades, to the control of gene expression in the nucleus and the subsequent regulation of cellular processes. (cardiff.ac.uk)
  • 2015. Protein Kinase C is involved in the induction of ATP-Binding cassette transporter A1 expression by liver X receptor/retinoid X receptor agonist in human macrophages . (cardiff.ac.uk)
  • Thus, these results suggest that p53 suppresses the expression of cell cycle regulatory genes though inhibiting both CCAAT binding factors, CBF/HSP70 and NF-Y. (bvsalud.org)
  • Whilst, several phase II drugs as well as endogenous & exogenous steroids/steroid metabolites have been identified as inducers of gene transcription, the cellular transcription factors controlling the expression of AKR1C1 are incompletely elucidated. (temple.edu)
  • purchase OSI-420 Since expression of C/EBP and C/EBP overlaps in the development of myeloid cells, both factors play crucial roles and may, at least in part, purchase OSI-420 functionally compensate for each other in myelopoiesis and innate immune response. (cancercurehere.com)
  • We describe here a gene expression- and bioinformatics-based study showing that celastrol, a natural triterpenoid, acting via MAPK pathway regulates the downstream genes encoding serum/glucocorticoid regulated kinase 1 (SGK1), which plays a vital role in Th17/Treg differentiation, and brain-derived neurotrophic factor (BDNF), which is a neurotrophic factor, thereby offering protection against experimental autoimmune encephalomyelitis (EAE) in mice. (springer.com)
  • The UPR includes at least three signaling pathways initiated by the kinases IRE1 and PERK and the transcription factor ATF6 [ 3 ] signals that coordinate the cellular response to unfolded proteins, which includes (a) downregulation of protein translation, (b) enhanced expression of ER chaperone proteins that promote protein refolding, and (c) activation of proteases involved in the degradation of misfolded proteins. (hindawi.com)
  • Furthermore, genes are often flanked by several binding sites for distinct transcription factors, and efficient expression of each of these genes requires the cooperative action of several different transcription factors (see, for example, hepatocyte nuclear factors). (wikiversity.org)
  • Tan-IIA also induced ER stress in prostate cancer cells: activation and nuclear translocation of GADD153/CCAAT/enhancer-binding protein-homologous protein (CHOP) were identified, and increased expression of the downstream molecules GRP78/BiP, inositol-requiring protein-1α and GADD153/CHOP were evidenced. (nature.com)
  • 2010). The transcription factor Nrf2 is a key cellular component that defends cells against toxicities of oxidants and electrophiles by regulating both constitutive and inducible expression of many antioxidant/detoxification enzymes (Fu et al. (medscape.com)
  • Chang, C.J., Chen, Y.L. & Lee, S.C. Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. (nature.com)
  • Sterol regulatory element binding proteins (SREBPs) are transcription factors that regulate the expression of genes for both cholesterol and fatty acid synthesis. (biomedsearch.com)
  • To determine the underlying mechanism of the synergy between DMC and TRAIL, we have demonstrated that DMC induces a CCAAT/enhancer binding protein homologous protein-dependent expression of DR5, a major TRAIL receptor, and reduces the levels of cellular FLICE-inhibitory protein (c-FLIP) (both the long and short forms), key inhibitors of death receptor-mediated apoptosis, by facilitating c-FLIP degradation through a ubiquitin/proteasome-dependent mechanism. (aspetjournals.org)
  • These findings suggest that reducing expression or activity of the Klf4 transcription factor in tumor myeloid cells may contribute to prostate cancer therapy. (bireme.br)
  • Often these protein factors act in a complex combinatorial manner allowing temporal, spatial, and environmentally responsive control of gene expression ( 2 ). (pnas.org)
  • In mature adipocytes, GB reduced the gene expression of resistin, a pro-inflammatory endocrine factor, increased the adiponectin protein levels in a time-dependent manner, and substantially attenuated the TNF-alpha-induced reduction in adiponectin. (mdpi.com)
  • Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements. (semanticscholar.org)
  • Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress. (semanticscholar.org)
  • Increased expression of nerve growth factor (NGF) has been found in the myocardium suffered from ischemia and reperfusion (I/R). The pro-survival activity of NGF on ischemic heart has been supposed to be mediated by phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. (medsci.org)
  • Myocardial apoptosis rate was measured by TUNEL staining, and expression of glucose-related protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), caspase-12, total- and phospho-(Ser473)-Akt were assessed by Western blot analyses. (medsci.org)
  • Tissue- and stage-specific expression, as well as variable DNA-binding specificities, contributes to the differences in the biologic functions of the C/EBP isoforms. (bloodjournal.org)
  • Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding proteins (e.g. (aacrjournals.org)
  • Altered RNA binding protein expression in CML-BC. (aacrjournals.org)
  • 8 ], which demonstrated an increased expression for this gene during neuronal cell death induced by NGF (nerve growth factor) depletion. (biochemsoctrans.org)
  • Nature Reviews Molecular Cell Biology 7, 885-896 (December 2006) doi:10.1038/nrm2066: Fig 3: Signals from activators and repressors of adipogenesis are integrated in the nucleus by transcription factors that directly or indirectly regulate expression of peroxisome proliferator-activated receptor (PPAR) and CCAAT-enhancer-binding protein (C/EBP). (nikas-culinaria.com)
  • The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. (embl.de)
  • Myocyte enhancer factor-2 (MEF2) proteins are a family of transcription factors which through control of gene expression are important regulators of cellular differentiation and consequently play a critical role in embryonic development. (wikiversity.org)
  • Electrophoretic mobility shift (EMSAs) and gel supershift assays demonstrated that the transcription factor NF-Y preferentially binds to the inverted CCAAT box at -109ATTGG-105 of the AKR1C1 gene. (temple.edu)
  • Binds preferentially to the 5-[CU]CUGCG-3 motif in vitro. (genecards.org)
  • By using PCR-mediated random binding selection process, researchers were able to show that the sequence "3' - (T/C)G ATTGG (T/C)(T/C)(A/G) - 5'" immediately flanking the ATTGG region (CCAAT in the complementary strand) was preferentially selected on the coding strand (opposite of the template strand). (wikipedia.org)
  • encodes a B3 domain transcription factor preferentially expressed during early and late zygotic embryo development. (biomedcentral.com)
  • 1) Chronic hyperinsulinemia, in affected individuals, may promote cancer, as insulin can exert its oncogenic potential via abnormal stimulation of multiple cellular signaling cascades, enhancing growth factor-dependent cell proliferation and/or by directly affecting cell metabolism. (hindawi.com)
  • Protein limitation in vivo or amino acid deprivation of cells in culture causes a signal transduction cascade consisting of activation of the kinase GCN2 (general control nonderepressible 2), phosphorylation of eukaryotic initiation factor 2, and increased synthesis of activating transcription factor (ATF) 4 by a translational control mechanism. (semanticscholar.org)
  • NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. (embl.de)
  • In addition to ER chaperones, the mammalian transcription factor CHOP (also called GADD153) is induced by ER stress. (asm.org)
  • As the general transcription factor NF-Y (also known as CBF) binds to CCAAT, CCACG is considered to provide specificity in the mammalian UPR. (asm.org)
  • This cis -acting regulatory sequence containing the pentanucleotide sequence CCAAT is responsible for transcriptional repression of pcl1 + under low iron supply conditions. (asm.org)
  • In contrast, when iron is scarce, Fep1 becomes inactive and php4 + is expressed to act as a regulatory subunit of the CCAAT-binding factor that is required to block pcl1 + , sdh4 + , and isa1 + gene transcription. (asm.org)
  • The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. (nih.gov)
  • Insulin-like growth factor I (IGF-I) and IGF-II, acting under the regulatory control of growth hormone, are the principal mediators of vertebrate growth. (elsevier.com)
  • Macrophages, but not monocytes, were able to activate IFN-stimulated gene factor-3 (ISGF-3), a transcription factor composed of STAT-1, STAT-2, and IFN regulatory factor (IRF)-9, after infection with M. tuberculosis or stimulation with type I IFN. (jimmunol.org)
  • Lipogenic enzymes fatty acid synthase and acetyl-coenzyme A carboxylase are coexpressed with sterol regulatory element binding protein and Ki-67 in fetal tissues. (biomedsearch.com)
  • two of these mechanisms are common to other regulatory pathways (activation of CREB by cAMP and regulation of GATA factors in the sonic hedgehog (SHH) pathway). (nikas-culinaria.com)
  • E2F acts as a co-repressor of another transcription factor, C/EBPa, without binding to cis-regulatory elements, but by direct protein-protein interactions that abolish the binding of C/EBPa to DNA. (hu-berlin.de)
  • These proteins are known as CCAAT box binding proteins/CCAAT box binding factors. (wikipedia.org)
  • These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. (nih.gov)
  • Insulin and IGF-I inhibit the hepatic synthesis of sex-hormone binding globulin (SHBG), whereas both hormones stimulate the ovarian synthesis of sex steroids, whose effects, in breast epithelium and endometrium, can promote cellular proliferation and inhibit apoptosis. (hindawi.com)
  • The underlying cellular mechanisms leading to insulin resistance are unknown but are believed to be due to defects in insulin signal transduction and not to defects in the insulin receptor itself or insulin:insulin receptor binding. (diabetesjournals.org)
  • The method enables determination of PTM-dependent transcription factor interactions, quantification of relative binding affinities and rapid protein classification, all independently of the transactivation potential of peptides or cellular abundance of interactors. (nature.com)
  • Such control is achieved through specific transcription factors that act as master regulators of various cellular functions. (bloodjournal.org)
  • C/EBP homologous protein (CHOP), also known as growth arrest and DNA damage-inducible protein 153 (GADD153), belongs to the CCAAT/enhancer-binding protein (C/EBP) family. (frontiersin.org)
  • We report here that the transcription factor XBP-1 (also called TREB5) is also induced by ER stress and that induction of CHOP and XBP-1 is mediated by ERSE. (asm.org)
  • Furthermore, we demonstrated that soluble ATF6 binds directly to CCACG only when CCAAT exactly 9 bp upstream of CCACG is bound to NF-Y. Based on these and other findings, we concluded that specific and direct interactions between ATF6 and ERSE are critical for transcriptional induction not only of ER chaperones but also of CHOP and XBP-1. (asm.org)
  • The transmembrane protein kinase Ire1p (also known as Ern1p) is considered to function as a sensor molecule of ER stress ( 8 , 32 ), and the basic leucine zipper (bZIP) protein Hac1p is a yeast UPR-specific transcription factor ( 9 , 31 , 36 ) that activates transcription of target genes in the nucleus through binding to the cis -acting UPR element ( 34 , 35 ). (asm.org)
  • CCAAT/enhancer binding protein-β (C/EBPβ) and NF-E2-related factor-2 (Nrf2) are both involved in the regulation of the genes encoding phase II detoxification enzymes including glutathione S -transferase (GST). (aspetjournals.org)
  • This is accomplished by the upregulation of a vast array of regeneration-associated genes (RAGs) including the rapid induction of transcription factors and enhanced synthesis of adhesion molecules, cytoskeletal elements, growth factors, cytokines, neuropeptides, and other molecules involved in regeneration. (frontiersin.org)
  • [8] Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins. (wikiversity.org)
  • Whereas genes might be readily controlled by directing transcription factors to particular sites within a genome, the design of DNA-binding proteins that might be fashioned to bind any given sequence has been a daunting challenge. (pnas.org)
  • 25 Recent studies suggest that the murine Per2 gene, another key factor of the circadian system, is involved in tumor suppression by regulating cell cycle- and apoptosis-related genes. (bloodjournal.org)
  • This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. (medlineplus.gov)
  • CCAAT/Enhancer binding proteins (C/EBPs) play important roles in the regulation of cell growth and differentiation. (nih.gov)
  • The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction of several inflammatory mediators. (cancercurehere.com)
  • CCAAT-enhancer-binding proteins (or C/EBPs) are a family of transcription factors , composed of six members called C/EBP α to C/EBP ζ. (thefullwiki.org)
  • Once bound to DNA, C/EBPs can recruit so-called coactivators (such as CBP, see ref. 2) that, in turn, can open up chromatin structure, or recruit basal transcription factors. (thefullwiki.org)
  • The different members of C/EBP family can form homodimers, heterodimers with another form of the C/EBPs and with other transcription factors that may or may not contain the leucine zipper domain. (thefullwiki.org)
  • The dimerization is required for the activity of C/EBPs to bind specifically to DNA through a palindromic sequence in the major groove of the DNA. (thefullwiki.org)
  • CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcription factors that regulate cell growth and differentiation in numerous cell types. (bloodjournal.org)
  • As for the transcription factors involved in early adipogenesis, JNK inactivation significantly inhibited the induction of C/ebpd , but not C/ebpb , during the initial stage of adipogenic differentiation. (biochemj.org)
  • JunB contributes to Smad-mediated repression of inhibitor of differentiation 2 through interaction with transcription repressor activating transcription factor 3. (biomedsearch.com)
  • Schematic representation of the BCR/ABL-induced and RNA binding protein-mediated pathways affecting proliferation survival and differentiation of CML-BC progenitors. (aacrjournals.org)
  • In this issue of Blood , Bartels and colleagues demonstrate that acetylation of the transcription factor CCAAT enhancer binding protein ε (C/EBPε) is essential for terminal neutrophil granulocyte differentiation. (bloodjournal.org)
  • The C/EBP transcription factor family is essential for granulopoiesis and terminal differentiation of neutrophils. (bloodjournal.org)
  • The transcription factor CCAAT/Enhancer-Binding Protein alpha (C/EBPa) coordinates proliferation arrest and differentiation of myeloid progenitors and adipocytes. (hu-berlin.de)
  • A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one motif that recognizes double- or single-stranded DNA. (wikiversity.org)
  • Within metazoa (animal kingdom), the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the sequences flanking this pentameric motif. (wikipedia.org)
  • While no single nucleotide was selected in every clone on either side of the ATTGG motif (CCAAT in the complementary strand), there were several nucleotides in positions selected with high frequency. (wikipedia.org)
  • We recently found that the basic leucine zipper protein ATF6 isolated as a CCACG-binding protein is synthesized as a transmembrane protein in the ER, and ER stress-induced proteolysis produces a soluble form of ATF6 that translocates into the nucleus. (asm.org)
  • CCAAT/enhancer binding protein (C/EBP)ε, a member of the leucine zipper family of transcription factors, is expressed primarily in myeloid cells, and its knockout mouse model possesses distinctive defects, including a lack of neutrophil secondary granule proteins. (rupress.org)
  • Their amino end includes a transcriptional activation domains, as well as the carboxyl terminal area includes a simple leucine zipper theme that forms homo- or hetero-dimers and enables binding to DNA. (cancercurehere.com)
  • This domain is involved in dimerization and DNA binding like other transcription factors of the leucine zipper family like c-Fos and Jun. (thefullwiki.org)
  • This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. (genecards.org)
  • The regulation of C/EBPβ is exerted in many manners, phosphorylation , acetylation , activation and repression via others transcription factors, oncogenic elements or chemokines , autoregulation, etc. (thefullwiki.org)
  • Effector domains, such as the activation domain VP16 ( 4 ) and the repression domain Krüppel-associated box (KRAB) ( 5 ), are typically modular and retain their activity when they are fused to other DNA-binding proteins. (pnas.org)
  • JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-β. (biomedsearch.com)
  • 1 Phosphorylation of C/EBPε on threonine 75, which is located in the transactivation domain, leads to increased DNA binding and transcriptional activity, and sumolyation of a lysine residue 121 (K121) within repression domain I enhances transcriptional activation by C/EBPε. (bloodjournal.org)
  • They cause transcriptional cleavage or translational repression through binding their target mRNAs. (biomedcentral.com)
  • 1 Binding of pathogen- or damage-associated molecular patterns to specific cell surface or intracellular receptors, such as Toll-like receptors (TLRs), Nod-like receptors, and the receptor for advanced glycation endproducts, in immune cells initiates a cascade of molecular events that leads to the production of proinflammatory cytokines, chemokines, reactive oxygen and nitrogen species, and antimicrobial peptides, as well as enhanced phagocytic activity. (ahajournals.org)
  • In molecular biology, a CCAAT box (also sometimes abbreviated a CAAT box or CAT box) is a distinct pattern of nucleotides with GGCCAATCT consensus sequence that occur upstream by 60-100 bases to the initial transcription site. (wikipedia.org)
  • The molecular biology of the CCAAT-binding factor NF-Y". Gene. (wikipedia.org)
  • The genetic factor is linked to quantitative and/or qualitative defects in the insulin receptor (INSR) signaling pathway which regulates growth and metabolic responses to insulin, in insulin target cells and tissues [ 6 ]. (hindawi.com)
  • This region, in particular for the CAAT box, is located about 60-100 bases upstream (towards the 5' end), however no less than 27 base pairs away, from the initial transcription site or a eukaryote gene in which a complex of general transcription factors bind with RNA polymerase II prior to the initiation of transcription. (wikipedia.org)
  • and identified upstream signals that control these factors and thereby hepatocyte maturity during recovery from liver injury. (bmj.com)
  • Hypoxia had no effects on the secretion of interleukin (IL)-1β, IL-6, IL-8, IL-17A, tumor necrosis factor-alpha, macrophage migration inhibitory factor, monocyte chemoattractant protein-1, and macrophage colony-stimulating factor in the culture media. (nii.ac.jp)
  • HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells. (nih.gov)
  • Myeloid-derived suppressor cells (MDSCs) have been shown to contribute to tumor escape from host immune surveillance and to cancer progression by production of tumor-promoting soluble factors. (springer.com)
  • The mechanisms for this association are unknown, but hyperinsulinaemia (a hallmark of insulin resistance) and the increase in bioavailable insulin-like growth factor I (IGF-I) appear to have a role in tumor initiation and progression in insulin-resistant patients. (hindawi.com)
  • In this study, we primarily investigated DMC's cooperative effect with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on the induction of apoptosis and the underlying mechanisms in human non-small-cell lung cancer (NSCLC) cells. (aspetjournals.org)
  • Absence of the tumor suppressor function of CCAAT enhancer-binding protein alpha is believed to disrupt the regulation of blood cell production in the bone marrow, leading to the uncontrolled production of abnormal cells that occurs in acute myeloid leukemia. (medlineplus.gov)
  • Research in this laboratory ( 9 ) has identified that the two prominent factors in the resistance of pancreatic neoplasms to alkylating chemotherapeutic agents are ( a ) the high level of O 6 -methylguanine-DNA methyltransferase (MGMT) in the tumor and ( b ) the widespread mutation of p53 that prevents p53-mediated cell cycle arrest in response to DNA damage ( 10 ). (aacrjournals.org)
  • In Schizosaccharomyces pombe , the CCAAT-binding factor is a heteromeric DNA-binding complex that contains three subunits, designated Php2, Php3, and Php5. (asm.org)
  • CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. (embl.de)
  • Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. (embl.de)
  • CCAAT-binding factors A (CBF-A) and B (CBF-B) are two subunits of the heteromeric CCAAT-binding factor. (embl.de)
  • Several transcription factors, including peroxisome proliferator-activated receptor gamma 2 and CCAAT-enhancer-binding protein (C/EBP) α, β, and δ, are important for the process, whereas the stage-specific intracellular signal transduction regulating the onset of adipogenesis remains enigmatic. (biochemj.org)
  • In this study, the two key transcription factors for adipogenesis, PPAR? (jove.com)
  • University of Michigan's FIRCA award will support research at a newly established lab in Argentina examining CCAAT/enhancer binding proteins, heterochromatin and their relationship to adipogenesis, the formation of fat cells. (nih.gov)
  • a substance that contains one or more DNA-binding domains that are nucleotide-sequence specific is called a transcription factor . (wikiversity.org)
  • It is now well established that genomes are regulated at the level of transcription primarily through the action of proteins known as transcription factors that bind DNA in a sequence-specific fashion. (pnas.org)
  • GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding . (genecards.org)
  • Subunit NFYA associates with a tight dimer composed of the NFYB and NFYC subunits, resulting in a trimer that binds to DNA with high specificity and affinity. (wikipedia.org)
  • This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • The Ca 2+ /cAMP response element-binding protein (CREB) was initially identified as the main interlocutor in the dialogue between the synapse and the nucleus [1]. (wikiversity.org)
  • Heterochromatin is tightly coiled chromosomal material while CCAAT/enhancer binding proteins are a family of transcription factors. (nih.gov)
  • Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochemical and Biophysical Research Communications. (wikipedia.org)
  • This work demonstrates an association of C/EBPa to the RNA Pol I transcription factor UBF1, both proteins retained in large chromosomal foci. (hu-berlin.de)
  • A 76bp fragment conferred a 20-fold induction by SA in transgenic tobacco plants and protein binding studies indicated that the core sequence of this SARE is TTCGACCTCC [40]. (wikiversity.org)
  • Effect of site-specific mutations on C/EBP and NF-Y binding activity. (diabetesjournals.org)
  • Carboxyl-terminal deletions of this segment (or mutations in arginine residues in this carboxyl-terminal part) abolish DNA binding, but do not alter subunit interactions between CBF-A and CBF-B. Mutations in hydrophobic amino acids within the amino-terminal part of the evolutionarily conserved sequence at positions 252-334 result in loss of both DNA binding and subunit interaction activities. (embl.de)
  • Transcriptional regulation of the human alpha6 integrin gene by the transcription factor NFI during corneal wound healing. (nih.gov)
  • Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development. (wikiversity.org)
  • Inhibition of cell cycle progression correlates with loss of hyperphosphorylated Rb and up-regulation of p21 via p53 and/or transforming growth factor-β (TGF-β) activation depending on p53 status. (aacrjournals.org)
  • Down-regulation of AREG, AGTR1, M-CSF, and EGF, IGF, and VEGF receptors and up-regulation of GNA11 and IGFBP4 signify loss of growth factor support. (aacrjournals.org)
  • Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene. (wikipedia.org)
  • NFYA has been shown to interact with Serum response factor and ZHX1. (wikipedia.org)
  • NFYA, NFYB and NFYC form the NFY complex and it has been shown that the NFY complex serves as a pioneer factor by promoting chromatin accessibility to facilitate other co-localizing cell type-specific transcription factors. (wikipedia.org)
  • The CAAT box signals the binding site for the RNA transcription factor, and is typically accompanied by a conserved consensus sequence. (wikipedia.org)
  • A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity. (wikiversity.org)
  • The ERSE consensus sequence is CCAAT-N 9 -CCACG. (asm.org)
  • Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. (nature.com)
  • Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. (nature.com)
  • 2. Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR., CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation, J Biol Chem. (thefullwiki.org)
  • Wei K, Liu L, Xie F, Hao X, Luo J, Min S. Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by Activation of Phosphatidylinositol 3-Kinase. (medsci.org)
  • for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). (wikiversity.org)
  • The mechanism(s) that leads to activation of MAP kinase signaling with exercise could involve mechanical, systemic, autocrine, or paracrine factors, as well as a change in the energy status of the contracting muscle fibers. (thinkmuscle.com)
  • A simplified diagram of one intracellular signaling pathway associated with tyrosine kinase activity of the type 1 insulin-like growth factor receptor (IGFR1). (thinkmuscle.com)
  • Your search returned 119 CCAAT enhancer binding protein alpha ELISA ELISA Kit across 10 suppliers. (biocompare.com)
  • Der Transkriptionsfaktor CCAAT/Enhancer-Binding Protein alpha (C/EBPa) koordiniert Proliferationshemmung und Differenzierung von myeloiden VorlŠuferzellen und Adipozyten. (hu-berlin.de)