Chemicals and DrugsPhenomena and ProcessesInformation Science
CCAAT-Binding FactorCCAAT-Enhancer-Binding ProteinsCore Binding FactorsNFI Transcription FactorsY-Box-Binding Protein 1DNA-Binding ProteinsTranscription FactorsBase SequencePromoter Regions, GeneticMolecular Sequence DataCore Binding Factor beta SubunitPol1 Transcription Initiation Complex ProteinsCore Binding Factor alpha SubunitsTelomeric Repeat Binding Protein 1G-Box Binding FactorsCCAAT-Enhancer-Binding Protein-betaTranscription, GeneticCore Binding Factor Alpha 2 Subunit
CCAAT-Binding Factor
A heterotrimeric DNA-binding protein that binds to CCAAT motifs in the promoters of eukaryotic genes. It is composed of three subunits: A, B and C.
CCAAT-Enhancer-Binding Proteins
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Core Binding Factors
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
NFI Transcription Factors
Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.
Y-Box-Binding Protein 1
Y-box-binding protein 1 was originally identified as a DNA-binding protein that interacts with Y-box PROMOTER REGIONS of MHC CLASS II GENES. It is a highly conserved transcription factor that regulates expression of a wide variety of GENES.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Promoter Regions, Genetic
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Core Binding Factor beta Subunit
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Pol1 Transcription Initiation Complex Proteins
Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.
Core Binding Factor alpha Subunits
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
Telomeric Repeat Binding Protein 1
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.
G-Box Binding Factors
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.
CCAAT-Enhancer-Binding Protein-beta
A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Core Binding Factor Alpha 2 Subunit
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. (1/416)

The ergosterol biosynthetic pathway is a specific branch of the mevalonate pathway. Since the cells requirement for sterols is greater than for isoprenoids, sterol biosynthesis must be regulated independently of isoprenoid biosynthesis. In this study we explored the transcriptional regulation of squalene synthase (ERG9) in Saccharomyces cerevisiae, the first enzyme dedicated to the synthesis of sterols. A mutant search was performed to identify genes that were involved in the regulation of the expression of an ERG9-lacZ promoter fusion. Mutants with phenotypes consistent with known sterol biosynthetic mutations (ERG3, ERG7, ERG24) increased expression of ERG9. In addition, treatment of wild-type cells with the sterol inhibitors zaragozic acid and ketoconazole, which target squalene synthase and the C-14 sterol demethylase respectively, also caused an increase in ERG9 expression. The data also demonstrate that heme mutants increased ERG9 expression while anaerobic conditions decreased expression. Additionally, the heme activator protein transcription factors HAP1 and HAP2/3/4, the yeast activator protein transcription factor yAP-1, and the phospholipid transcription factor complex INO2/4 regulate ERG9 expression. ERG9 expression is decreased in hap1, hap2/3/4, and yap-1 mutants while ino2/4 mutants showed an increase in ERG9 expression. This study demonstrates that ERG9 transcription is regulated by several diverse factors, consistent with the idea that as the first step dedicated to the synthesis of sterols, squalene synthase gene expression and ultimately sterol biosynthesis is highly regulated.  (+info)

Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex. (2/416)

The observation that cyclin B1 protein and mRNAs are down-regulated in terminally differentiated (TD) C2C12 cells, suggested us to investigate the transcriptional regulation of the cyclin B1 gene in these cells. Transfections of cyclin B1 promoter constructs indicate that two CCAAT boxes support cyclin B1 promoter activity in proliferating cells. EMSAs demonstrate that both CCAAT boxes are recognized by the trimeric NF-Y complex in proliferating but not in TD cells. Transfecting a dominant-negative mutant of NF-YA we provide evidence that NF-Y is required for maximal promoter activity. Addition of recombinant NF-YA to TD C2C12 nuclear extracts restores binding activity in vitro, thus indicating that the loss of NF-YA in TD cells is responsible for the lack of the NF-Y binding to the CCAAT boxes. Consistent with this, we found that the NF-YA protein is absent in TD C2C12 cells. In conclusion, our data demonstrate that NF-Y is required for cyclin B1 promoter activity. We also demonstrate that cyclin B1 expression is regulated at the transcriptional level in TD C2C12 cells and that the switch-off of cyclin B1 promoter activity in differentiated cells depends upon the loss of a functional NF-Y complex. In particular the loss of NF-YA protein is most likely responsible for its inactivation.  (+info)

Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays. (3/416)

The yeast SWI/SNF complex is required for the transcription of several yeast genes and has been shown to alter nucleosome structure in an ATP-dependent reaction. In this study, we show that the complex stimulated in vitro transcription from nucleosome templates in an activation domain-dependent manner. Transcription stimulation by SWI/SNF required an activation domain with which it directly interacts. The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts. The similarity of activation domain interactions and transcriptional stimulation between SWI/SNF and the SAGA histone acetyltransferase complex may account for their apparent overlapping functions in vivo.  (+info)

Identification of proteins that interact with NF-YA. (4/416)

We used the yeast two-hybrid system to show that the serum response factor (SRF) and zinc-fingers and homeobox 1 (ZHXI) proteins interact with the A subunit of nuclear factor-Y (NF-YA). GST pulldown assays revealed that both proteins interact specifically with NF-YA in vitro. Amino acids located between 272 and 564, a region that contains two homeodomains, are required for the interaction of ZHX1 with NF-YA. Two different domains of NF-YA, a glutamine-rich region and a serine/threonine-rich region, are necessary for the interactions with ZHX1 and SRF, respectively.  (+info)

A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene. (5/416)

Proper regulation of the human CD34 gene requires a combinatorial action of multiple proximal and long-range, cis elements. This report shows that, like the murine CD34 5' untranslated region (UTR), the corresponding region of the human CD34 gene is necessary for optimal promoter activity. We localized the most critical element of this region to base pairs +48/+75. Through oligonucleotide competition and antibody supershift experiments in electrophoretic mobility shift assays, we found that this sequence contains a binding site (CCAAT box) for the transcription factor NFY (nuclear factor Y), a factor mediating cell type-specific and cell-cycle regulated expression of genes. Mutating this site led to a 5-fold decrease in CD34 promoter activity in transient transfection experiments. Interestingly, NFY binds adjacently to the earlier identified c-myb binding site. Here we show that both binding sites are important for CD34 promoter function: mutating either site alone decreased CD34 promoter-driven reporter gene activity 4-fold. We also show that the integrity of the c-myb binding site is necessary for stabilization of NFY binding to its site. Such cooperation between c-myb, which is expressed in early hematopoietic cells, and NFY, which is expressed in many cell types, might contribute to specific activation of CD34 in stem cells. The CCAAT box motif was also noted in the 5' UTR of the murine CD34 gene, however, NFY did not bind to this region. Thus, our results indicate that the functional similarities between the human and murine CD34 5' UTRs are achieved through different molecular mechanism(s).  (+info)

Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene. (6/416)

5812 base pairs of rat GTP cyclohydrolase I (GTPCH) 5'-flanking region were cloned and sequenced, and the transcription start site was determined for the gene in rat liver. Progressive deletion analysis using transient transfection assays of luciferase reporter constructs defined the core promoter as a highly conserved 142-base pair GC-rich sequence upstream from the cap site. DNase I footprint analysis of this region revealed (5' --> 3') a Sp1/GC box, a noncanonical cAMP-response element (CRE), a CCAAT-box, and an E-box. Transcription from the core promoter in PC12 but not C6 or Rat2 cells was enhanced by incubation with 8-bromo-cyclic AMP. Mutagenesis showed that both the CRE and CCAAT-box independently contribute to basal and cAMP-dependent activity. The combined CRE and CCAAT-box cassette was also found to enhance basal transcription and confer cAMP sensitivity on a heterologous minimal promoter. The addition of the Sp1/GC box sequence to this minimal promoter construct inhibited basal transcription without affecting the cAMP response. EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor (ATF)-4 and CCAAT enhancer-binding protein beta, while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT-box as a complex containing nuclear factor Y. Overexpression of ATF-4 in PC12 cells was found to transactivate the GTPCH promoter response to cAMP. These studies suggest that the elements required for cell type-specific cAMP-dependent enhancement of gene transcription are located along the GTPCH core promoter and include the CRE and adjacent CCAAT-box and the proteins ATF-4, CCAAT enhancer-binding protein beta, and nuclear factor Y.  (+info)

Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. (7/416)

To understand cholesterol-mediated regulation of human fatty acid synthase promoter I, we tested various 5'-deletion constructs of promoter I-luciferase reporter gene constructs in HepG2 cells. The reporter gene constructs that contained only the Sp-1-binding site (nucleotides -82 to -74) and the two tandem sterol regulatory elements (SREs; nucleotides -63 to -46) did not respond to cholesterol. Only the reporter gene constructs containing a nuclear factor-Y (NF-Y) sequence, the CCAAT sequence (nucleotides -90 to -86), an Sp-1 sequence, and the two tandem SREs responded to cholesterol. The NF-Y-binding site, therefore, is essential for cholesterol response. Mutating the SREs or the NF-Y site and inserting 4 bp between the Sp-1- and NF-Y-binding sites both resulted in a minimal cholesterol response of the reporter genes. Electrophoretic mobility-shift assays using anti-SRE-binding protein (SREBP) and anti-NF-Ya antibodies confirmed that these SREs and the NF-Y site bind the respective factors. We also identified a second Sp-1 site located between nucleotides -40 and -30 that can substitute for the mutated Sp-1 site located between nucleotides -82 and -74. The reporter gene expression of the wild-type promoter and the Sp-1 site (nucleotides -82 to -74) mutant promoter was similar when SREBP1a [the N-terminal domain of SREBP (amino acids 1-520)] was constitutively overexpressed, suggesting that Sp-1 recruits SREBP to the SREs. Under the same conditions, an NF-Y site mutation resulted in significant loss of reporter gene expression, suggesting that NF-Y is required to activate the cholesterol response.  (+info)

Redirection of the respiro-fermentative flux distribution in Saccharomyces cerevisiae by overexpression of the transcription factor Hap4p. (8/416)

Reduction of aerobic fermentation on sugars by altering the fermentative/oxidative balance is of significant interest for optimization of industrial production of Saccharomyces cerevisiae. Glucose control of oxidative metabolism in baker's yeast is partly mediated through transcriptional regulation of the Hap4p subunit of the Hap2/3/4/5p transcriptional activator complex. To alleviate glucose repression of oxidative metabolism, we constructed a yeast strain with constitutively elevated levels of Hap4p. Genetic analysis of expression levels of glucose-repressed genes and analysis of respiratory capacity showed that Hap4p overexpression (partly) relieves glucose repression of respiration. Analysis of the physiological properties of the Hap4p overproducer in batch cultures in fermentors (aerobic, glucose excess) has shown that the metabolism of this strain is more oxidative than in the wild-type strain, resulting in a significant reduced ethanol production and improvement of growth rate and a 40% gain in biomass yield. Our results show that modification of one or more transcriptional regulators can be a powerful and a widely applicable tool for redirection of metabolic fluxes in microorganisms.  (+info)

Anti-Human YB-1 Antibody | Human YB-1 Antibody | YB-1 AntibodyAnti-Human YB-1 Antibody | Human YB-1 Antibody | YB-1 Antibody
Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cancer_and_Inflammation/YB-1?sitex=10020:22372:US&PEBCL1=Dm7FTxG1FysZdkrBbUhf5DYMmG&PEBCL1_pses=ZGC4A6FA625F7A680505A469470BE11678F412EBC881A2F2AF1B86A6E123958A18D38BCB6D5BF3FB3075DA61477DCD2CD4A82AFC1EAC80FE84
Nfyc - Nuclear transcription factor Y subunit gamma - Mus musculus (Mouse) - Nfyc gene & proteinNfyc - Nuclear transcription factor Y subunit gamma - Mus musculus (Mouse) - Nfyc gene & protein
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
https://www.uniprot.org/uniprot/P70353
6qmp - Proteopedia, life in 3D6qmp - Proteopedia, life in 3D
Protein complex formation highly depends on the interplay between preorganization and flexibility of involved binding epitopes. The design of epitope mimetics mainly focuses on the stabilization of a particular bioactive conformation often not considering the conformational dynamics. This limits the potential of peptidomimetics in particular when aiming for challenging targets such as transcription factors. Here, we report the first peptide-derived inhibitor of the NF-Y transcription factor by first constraining the conformation of an epitope using the hydrocarbon stapling approach and then fine-tuning its flexibility. In the initial set of constrained peptides, we observed a severe effect of a single non-interacting alpha-methyl group on complex stability. The combination of X-ray and NMR structures as well as isothermal titration calorimetry and CD spectroscopy reveal how this methyl group affects the conformation of the peptide in its bound state. Adaption of the methylation pattern results ...
http://proteopedia.org/wiki/index.php/6qmp
AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the...AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the...
One subunit of the transcription factor NF-Y maps close to the major by X Y. Li, M G. Mattei et al.One subunit of the transcription factor NF-Y maps close to the major by X Y. Li, M G. Mattei et al.
The genes coding for the A and B subunits of the transcription factor NF-Y are assigned by a combination of in situ hybridization and analysis of somatic cell hybrids and recombinant mouse strains. NF-YA is assigned to human chromosome 6p21 and to mouse chromosome 17. NF-YB is assigned to human chromosome 12 and to mouse chromosome 10.
https://mouseion.jax.org/stfb1990_1999/217/
Active Motif » TransAM NF-YA (Nuclear factor Y, alpha or CAAT-box binding protein subunit A DNA binding ELISA)Active Motif » TransAM NF-YA (Nuclear factor Y, alpha or CAAT-box binding protein subunit A DNA binding ELISA)
TransAM NF-YA Kits are DNA-binding ELISAs that quantify activated NF-YA (nuclear factor Y, alpha) using a method that is faster and more sensitive than gelshift, without radioactivity and gels.
http://www.activemotif.jp/catalog/214/transam-nf-ya
Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription...Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription...
Thank you for sharing this Molecular and Cellular Biology article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
https://mcb.asm.org/content/12/4/1846/figures-only
miRNA Search ResultsmiRNA Search Results
of loci miR156 ND d 1 miR159 MYB and TCP TFs e b 2 miR160 ND d 1 miR162 DICER-LIKE 1 b 1 miR164 ND a 1 miR166 HD-Zip TFs f, h, k h, k, n h, n c 9 miR167 Auxin response factors TFs a, d, f j d a 6 miR168 ARGONAUTE b 1 miR169 CCAAT binding factor and HAP2-like TFs n, p c 3 miR171 SCARECROW-like TFs c, e, f c c, d a 7 miR319 ND a 1 miR395 ATP sulphurylases i, j, k 3 miR396 GRF TFs, rhodenase-like, and kinesin-like protein B b 1 miR397 Laccases and beta-6 tubulin a a 2 miR399 Phosphatase TFs e b, e 3 miR418 ND x x 2 miR420 ND x x x 3 miR441 ND b a, b, c c 5 miR442 ND x x x 3 miR446 ND x x x 3 miR531 ND x x 2 miR535 ND x x x x 4 Total no. [score:1] ...
http://mirbase.org/cgi-bin/sentences.pl?acc=MI0001100
miRNA Search ResultsmiRNA Search Results
of loci miR156 ND d 1 miR159 MYB and TCP TFs e b 2 miR160 ND d 1 miR162 DICER-LIKE 1 b 1 miR164 ND a 1 miR166 HD-Zip TFs f, h, k h, k, n h, n c 9 miR167 Auxin response factors TFs a, d, f j d a 6 miR168 ARGONAUTE b 1 miR169 CCAAT binding factor and HAP2-like TFs n, p c 3 miR171 SCARECROW-like TFs c, e, f c c, d a 7 miR319 ND a 1 miR395 ATP sulphurylases i, j, k 3 miR396 GRF TFs, rhodenase-like, and kinesin-like protein B b 1 miR397 Laccases and beta-6 tubulin a a 2 miR399 Phosphatase TFs e b, e 3 miR418 ND x x 2 miR420 ND x x x 3 miR441 ND b a, b, c c 5 miR442 ND x x x 3 miR446 ND x x x 3 miR531 ND x x 2 miR535 ND x x x x 4 Total no. [score:1] ...
https://mirbase.org/cgi-bin/sentences.pl?acc=MI0005090
Plus itPlus it
There is evidence that transcriptional control of topo IIα regulation is important in regulating gene expression at confluence (Isaacs et al., 1996), and under heat-shock conditions (Furukawa et al., 1998). A recent study indicated that transcriptional elements may regulate the cell cycle control of topo IIα expression (Falck et al., 1999). Furthermore, p53 may directly repress the promoter (Sandri et al., 1996b; Wang et al., 1997). The oncogenes ras andmyb have also been demonstrated to act through specific sequences within the topo IIα promoter. Both heat-shock and cell cycle regulation have been demonstrated to act through the ICB1 in the promoter (Falck et al., 1999), whereas confluence-induced down-regulation is regulated through the ICB2. This study confirms that, unlike with cell cycle regulation, the transcription factor NF-Y forms part of the ICB binding complex. There is an alteration in the intensity of the in vitro footprint seen at confluence, although this is not associated with ...
http://molpharm.aspetjournals.org/content/59/4/699
A Transcriptional Regulatory Module Enhances Lipid Accumulation in Soybean Seeds----Institute of Genetics and Developmental...A Transcriptional Regulatory Module Enhances Lipid Accumulation in Soybean Seeds----Institute of Genetics and Developmental...
This regulatory mechanism functions in two ways. If the downstream genes possess the binding elements of both GmZF392 and GmZF351 in their promoters, the two TZF proteins would play additively roles in activating downstream genes. But for some target genes, only one kind of binding elements is found in their promoter regions. In this case, GmZF392 and GmZF351 form a transcriptional complex to synergistically activate gene expression. Either way could guarantee the participation of the two TZF proteins, so that the downstream genes are up-regulated by two TZF proteins to a much higher level than by only one of them. The third member of this module is a nuclear factor Y subunit, namely GmNFYA. GmNFYA acts as an upstream activator of GmZF392 and GmZF351 in direct and indirect manner respectively ...
http://english.genetics.cas.cn/rh/rp/202104/t20210426_267824.html
SKF 1208EKTN9 bearing, 40x80x18, 1208EKTN9 bearing for sale | BIGON Bearing
d - 40 mm. D - 80 mm. B - 18 mm. C - 18 mm. d2 - 53,6 mm. r1 min. - 1,1 mm. r2 min. - 1,1 mm. D1 - 68,8 mm. da min. - 47 mm. Da max. - 73 mm. ra max. - 1,1 mm. Weight - 0,42 Kg. Basic dynamic load rating (C) - 19,9 kN. Basic static load rating (C0) - 6,95 kN. Fatigue load limit (Pu) - 0,36. Reference speed - 18000 r/min. Limiting speed - 11000 r/min. Calculation factor (e) - 0,22. Calculation factor (kr) - 0,04. Calculation factor (Y0) - 2,8. Calculation factor (Y1) - 2,9. Calculation factor (Y2) - 4,5. ...
https://cheapmotorhomes.co.za/bearings/SKF-bearing/1208EKTN9.html
SKF 1301ETN9 bearing, 12x37x12, 1301ETN9 bearing for sale | BIGON Bearing
d - 12 mm. D - 37 mm. B - 12 mm. C - 12 mm. d2 - 20 mm. r1 min. - 1 mm. r2 min. - 1 mm. D1 - 30,8 mm. da min. - 17,6 mm. Da max. - 31,4 mm. ra max. - 1 mm. Weight - 0,067 Kg. Basic dynamic load rating (C) - 9,36 kN. Basic static load rating (C0) - 2,16 kN. Fatigue load limit (Pu) - 0,12. Reference speed - 40000 r/min. Limiting speed - 28000 r/min. Calculation factor (e) - 0,35. Calculation factor (kr) - 0,04. Calculation factor (Y0) - 1,8. Calculation factor (Y1) - 1,8. Calculation factor (Y2) - 2,8. ...
http://www.normantrewhitt.co.uk/bearings/SKF-bearing/1301ETN9.html
CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue | DiabetesCCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue | Diabetes
FIG. 4. Effect of site-specific mutations on C/EBP and NF-Y binding activity. Nuclear extracts were prepared from 293T cells overexpressing C/EBP-α or -β. For mock, the cells were transfected by pcDNA. All probes were generated by PCR with 32P-labeled antisense primer and unlabeled sense primers using site-directed mutated plasmids as templates, and purified from the polyacrylamide gel, to equalize the specific activities between probes. A: DNA oligonucleotide sequence of wild and mutated probes used in EMSA. Mutated regions are indicated by lowercase with * with their name. B: EMSA using nuclear extracts of 293T cells overexpression C/EBP-α and C/EBP-β. Wild-type (wt) and mutant (m1, m2, m3, m4, and m5) probes were incubated with 4 μg of indicated nuclear extracts. The bands corresponding to NF-Y, C/EBP-α, and C/EBP-β are marked by arrows. C: Western blot (WB) analysis of C/EBP-α and -β for validating the expression of C/EBP-α and -β. 293T cells were transfected with expression ...
https://diabetes.diabetesjournals.org/content/53/11/2757.figures-only
Formation of a regulatory factor X/X2 box-binding protein/nuclear factor-Y multiprotein complex on the conserved regulatory...Formation of a regulatory factor X/X2 box-binding protein/nuclear factor-Y multiprotein complex on the conserved regulatory...
Thank you for your interest in spreading the word about The Journal of Immunology.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://www.jimmunol.org/content/159/8/3899/tab-article-info
Most recent papers with the keyword SKA2 | Read by QxMDMost recent papers with the keyword SKA2 | Read by QxMD
We previously identified proline-rich protein 11 (PRR11) as a novel cancer-related gene that is implicated in the regulation of cell cycle and tumorigenesis. Our recent study demonstrated that PRR11 and its adjacent gene, kinetochore associated 2 (SKA2), constitute a classic head-to-head gene pair that is coordinately regulated by nuclear factor Y (NF-Y). In the present study, we further show that the PRR11-SKA2 bidirectional transcription unit is an indirect target of the tumor suppressor p53. A luciferase reporter assay revealed that overexpression of wild type p53, but not mutant p53, significantly represses the basal activity and NF-Y mediated transactivation of the PRR11-SKA2 bidirectional promoter ...
https://www.readbyqxmd.com/keyword/120628
Addgene: pTBRII / CEP-Zeo / HygroAddgene: pTBRII / CEP-Zeo / Hygro
Plasmid pTBRII / CEP-Zeo / Hygro from Dr. Bert Vogelsteins lab contains the insert TGF beta type II receptor and is published in Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2412-6. This plasmid is available through Addgene.
http://www.addgene.org/16622/
Mustanahalise piloodi garaažist leiti silmus, kaassõitjad näitasid solidaarsust | Autosport | ERRMustanahalise piloodi garaažist leiti silmus, kaassõitjad näitasid solidaarsust | Autosport | ERR
Ameerika autospordisari NASCAR on sattunud järjekordse skandaali keskmesse, kui sarja ainsa mustanahalise sõitja Bubba Wallacei garaažist leiti pühapäeval silmus.
https://sport.err.ee/1105257/mustanahalise-piloodi-garaazist-leiti-silmus-kaassoitjad-naitasid-solidaarsust
NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor<...
TY - JOUR. T1 - NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. AU - Murai-Takeda, Ayano. AU - Shibata, Hirotaka. AU - Kurihara, Isao. AU - Kobayashi, Sakiko. AU - Yokota, Kenichi. AU - Suda, Noriko. AU - Mitsuishi, Yuko. AU - Jo, Rie. AU - Kitagawa, Hirochika. AU - Kato, Shigeaki. AU - Saruta, Takao. AU - Itoh, Hiroshi. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2010/3/12. Y1 - 2010/3/12. N2 - The role of aldosterone has been implicated in the metabolic syndrome and cardiovascular diseases. The biological actions of aldosterone are mediated through mineralocorticoid receptor (MR). Nuclear receptor-mediated gene expression is regulated by dynamic and coordinated recruitment of coactivators and corepressors. To identify new coregulators of the MR, full-length MR was used as bait in yeast two-hybrid screening. Weisolated NF-YC, one of the subunits of heterotrimeric transcription factor NF-Y. Specific interaction between MRand NF-YC was ...
https://keio.pure.elsevier.com/en/publications/nf-yc-functions-as-a-corepressor-of-agonist-bound-mineralocortico
Ectopic expression of the transforming growth factor beta type II receptor disrupts mesoderm organisation during mouse...Ectopic expression of the transforming growth factor beta type II receptor disrupts mesoderm organisation during mouse...
Zwijsen A., Goumans M.J., Lawson K.A., Van Rooijen M.A., Mummery C.L.. Transforming growth factor beta (TGFbeta) regulates the cell cycle and extracellular matrix (ECM) deposition of many cells in vitro. We have analysed chimaeric mouse embryos generated from embryonic stem cells with abnormal receptor expression to study the effect of TGFbeta on these processes in vivo and the consequences for normal development. The binding receptor for TGFbeta, TbetaRII, is first detected in the embryo proper around day 8.5 in the heart. Ectopic expression of TbetaRII from the blastocyst stage onward resulted in an embryonic lethal around 9.5 dpc. Analysis of earlier stages revealed that the primitive streak of TbetaRII chimaeras failed to elongate. Furthermore, although cells passed through the streak and initially formed mesoderm, they tended to accumulate within the streak. These defects temporally and spatially paralleled the expression of the TGFbeta type I receptor, which is first expressed in the node ...
https://www.uniprot.org/citations/10030593
STAT Protein Interference and Suppression of Cytokine Signal Transduction by Measles Virus V Protein | Journal of VirologySTAT Protein Interference and Suppression of Cytokine Signal Transduction by Measles Virus V Protein | Journal of Virology
Cytokine signal transduction is essential for normal immune function and controls the quality of responses to a wide variety of microbial infections. Innate and adaptive host responses to virus infections are regulated by autocrine and paracrine cytokine signaling systems. For most cytokines, receptor binding triggers an intracellular signaling cascade involving one or more signal transducer and activator of transcription (STAT) proteins. Diverse cytokine and growth factor signaling pathways produce active STAT transcription factors that specify mRNA induction profiles (26). For example, the alpha and beta interferon (IFN-α/β) family is of primary importance for both innate and adaptive antiviral immunity (reviewed in references 1, 49, and 53). In the innate antiviral system, IFN-α/β initiates a receptor-mediated signaling system that produces an activated STAT1-STAT2-IRF9 heterotrimeric transcription complex known as ISGF3 (27). The ISGF3 complex translocates to the nucleus, where it can ...
https://jvi.asm.org/content/77/13/7635?ijkey=6c144fe17e3224dacc8cfe310dedf22ec03362a2&keytype2=tf_ipsecsha
Ubiquitous Illin Ness Pdf Download - Generaccion.comUbiquitous Illin Ness Pdf Download - Generaccion.com
Ubiquitous Illin Ness Pdf Download Ubiquitous Illin Ness Pdf Download. Hey Guys, heres my fancy new solo called Ubiquitous Illin-ness from the new tapspace book Violent Tenor Cream played with my new Vic Firth Billy Club .. Landscape Performance Theory, an Introduction No matter how sophisticated you may be, .. NESS . do not have exact Informa tlon ag to the extent of the gamblin . ILLINI HALL May Made Begins Where Your Student Days Ended We are in harmony, .. What IKEA Tells Us About the Business Model of Law Practice . ness and was surprised at the .. Real-time spectrum analysis is used to predict and analyze . Ubiquitous (thank you, Dick .. A METASTABLE AUSTENITE WI!m PLANE STRESS FRACTURE TOUGH-NESS NEAR 500,000 . Download PDF to View . Ubiquitous Low-Cost Functionalized Multi-Walled Carbon .. Infrastructure Awareness . in ubiquitous computing systems in terms of accuracy and . ness model and a design space for Infrastructure Awareness.. The ubiquitous transcription factor NF-Y ...
http://www.generaccion.com/usuarios/516082/ubiquitous-illin-ness-pdf-download
T123166 Import.php caused a Catchable fatal error: Argument 1 passed to WikiPage::factoryT123166 Import.php caused a Catchable fatal error: Argument 1 passed to WikiPage::factory
3 0.9202 2743176 MediaWiki-,main( ) ..\MediaWiki.php:476 4 1.1621 3166096 MediaWiki-,performRequest( ) ..\MediaWiki.php:682 5 1.2004 3263184 SpecialPageFactory::executePath( ) ..\MediaWiki.php:249 6 1.2118 3300160 SpecialPage-,run( ) ..\SpecialPageFactory.php:553 7 1.2119 3300328 SpecialImport-,execute( ) ..\SpecialPage.php:384 8 1.6635 4171472 SpecialImport-,doImport( ) ..\SpecialImport.php:96 9 1.7125 4300008 WikiImporter-,doImport( ) ..\SpecialImport.php:205 10 4.2488 4992848 WikiImporter-,handlePage( ) ..\Import.php:567 11 4.2560 4994896 WikiImporter-,pageCallback( ) ..\Import.php:737 12 4.2560 4994928 call_user_func:{...\mw-26-00\includes\Import.php:446} ( ) ..\Import.php:446 13 4.2560 4994944 WikiImporter-,beforeImportPage( ) ..\Import.php:446 14 4.2560 4994976 WikiPage::factory( ) ..\Import.php: ...
https://phabricator.wikimedia.org/T123166
phpinfo()
configure --prefix=/usr --exec-prefix=/usr --bindir=/usr/bin --sbindir=/usr/sbin --sysconfdir=/etc --datadir=/usr/share --includedir=/usr/include --libdir=/usr/lib64 --libexecdir=/usr/libexec --sharedstatedir=/var/lib --mandir=/usr/share/man --infodir=/usr/share/info --build=x86_64-redhat-linux-gnu --host=x86_64-redhat-linux-gnu --target=x86_64-redhat-linux-gnu --program-prefix= --prefix=/opt/alt/php70 --exec-prefix=/opt/alt/php70 --bindir=/opt/alt/php70/usr/bin --sbindir=/opt/alt/php70/usr/sbin --sysconfdir=/opt/alt/php70/etc --datadir=/opt/alt/php70/usr/share --includedir=/opt/alt/php70/usr/include --libdir=/opt/alt/php70/usr/lib64 --libexecdir=/opt/alt/php70/usr/libexec --localstatedir=/var --with-curl=/opt/alt/curlssl/usr --sharedstatedir=/usr/com --mandir=/opt/alt/php70/usr/share/man --infodir=/opt/alt/php70/usr/share/info --cache-file=../config.cache --with-libdir=lib64 --with-config-file-path=/opt/alt/php70/etc ...
http://floordesignsfalkirk.co.uk/info.php
PHP: foreach - ManualPHP: foreach - Manual
注意: PHP 5 では、foreachの実行開始時に内部配列ポインタは、 配列の先頭要素を指すように自動的にリセットされます。 このため、foreachループの前に reset()をコールする必要はありません。 PHP 5 では、foreach は内部の配列ポインタに依存するので、 ループ内で配列ポインタを変更すると予期せぬ振る舞いを引き起こします。 PHP 7 では、foreach は内部の配列ポインタを使わなくなりました。 ...
http://us3.php.net/manual/ja/control-structures.foreach.php
利用PHP代码实现为任意页面设置访问密码 全百科网利用PHP代码实现为任意页面设置访问密码 全百科网
今日分享利用PHP代码实现为任意页面设置访问密码，实现方法很简单，小白也可以学会哈，具体请阅读本文吧。
http://www.quanbaike.com/news/4678.html
Редактирование вывода стандартной галереиРедактирование вывода стандартной галереи
Я так понимаю, что для редактирования вывода стандартной галереи, нужно в файле functions.php темы отключить шорткод вывода remove_shortcode(gallery);
https://n-wp.ru/redaktirovanie-vyivoda-standartnoy-galerei/
Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production. - Leibniz Institute for Natural Product...Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production. - Leibniz Institute for Natural Product...
The biosynthesis of the beta-lactam antibiotic penicillin in the filamentous fungus Aspergillus nidulans is catalyzed by three enzymes that are encoded by the acvA, ipnA, and aatA genes. A variety of cis-acting DNA elements and regulatory factors form a complex regulatory network controlling these beta-lactam biosynthesis genes. Regulators involved include the CCAAT-binding complex AnCF and AnBH1. AnBH1 acts as a repressor of the penicillin biosynthesis gene aatA. Until now, however, little information has been available on the signal transduction cascades leading to the transcription factors. Here we show that inhibition of protein kinase C (Pkc) activity in A. nidulans led to cytoplasmic localization of an AnBH1-enhanced green fluorescent protein (EGFP) fusion protein. Computer analysis of the genome and screening of an A. nidulans gene library revealed that the fungus possesses two putative Pkc-encoding genes, which we designated pkcA and pkcB. Only PkcA showed all the characteristic features ...
https://www.leibniz-hki.de/en/institut-publikationsdetails.html?publication=698
THE INTERPLAY AMONG NF-Y AND E-BOX TRANSCRIPTION FACTORS: MAX, MYC AND USF1THE INTERPLAY AMONG NF-Y AND E-BOX TRANSCRIPTION FACTORS: MAX, MYC AND USF1
Transcription is a process finely regulated by different transcription factors (TFs) which bind regulatory sequences present in gene promoters and allow the precise execution of gene expression programs. Misregulation of such process can lead to different pathologies, including development/differentiation defects, uncontrolled cell growth and cancer. For these reasons it is important to understand the molecular details of the interplay that occurs between different TFs to modulate gene expression. NF-Y, the heterotrimeric complex composed by NF-YA, NF-YB and NF-YC subunits, all required for DNA binding, recognizes the consensus sequence CCAAT, present in about 30% of eukaryotic promoters, at -60/-100 bp from the Transcription Start Site (TSS). One of the most important roles of NF-Y in transcription is to interact synergistically with other TFs to activate, or to repress, gene expression. In this study we focused on the relationship occurring between NF-Y and the TFs MAX, Myc and USF1, which ...
https://air.unimi.it/handle/2434/274117
TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves - ...TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves - ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
https://discovery.ucl.ac.uk/id/eprint/10477/
Tissue expression of NFYA - Staining in breast - The Human Protein AtlasTissue expression of NFYA - Staining in breast - The Human Protein Atlas
Expression of NFYA (CBF-B, HAP2, NF-YA) in breast tissue. Antibody staining with HPA050779 and CAB009250 in immunohistochemistry.
http://www.proteinatlas.org/ENSG00000001167-NFYA/tissue/breast
Search results for: lumene-20 | LOVERTESearch results for: lumene-20 | LOVERTE
2,70 €). Mugav, kiire ja 100% ilmastikukindel. NB! Tasuta alates 49 € ostukorv. Kui sooritada ost tööpäeviti (E-R) enne kella 15:00 on eeldatav kättesaamisaeg järgmise päeval. Reedel peale 15:00, laupäeval, pühapäeval ja riiklikel pühadel sooritatud ostud toimetatakse kliendini ülejärgmisel tööpäeval.. Automaatide asukohad ja lahtioleku kellaajad. Automaatide täitmis kellaajad. ...
https://www.loverte.com/en/search/?q=lumene-20
Trump: koroonaviiruse surmajuhtude arv USA-s tipneb kahe nädala pärast | Välismaa | ERRTrump: koroonaviiruse surmajuhtude arv USA-s tipneb kahe nädala pärast | Välismaa | ERR
USA president Donald Trump ütles pühapäeval, et Ühendriikides peaks koroonaviiruse surmajuhtude arv tipnema kahe nädala pärast, pikendades samas ka kodus püsimise korraldust.
https://www.err.ee/1070412/trump-koroonaviiruse-surmajuhtude-arv-usa-s-tipneb-kahe-nadala-parast
ISO 51432 thrust ball bearings | 51432 BearingISO 51432 thrust ball bearings | 51432 Bearing
QuestionISO 51432 thrust ball bearings ? Find 850 Bore Diameter (mm) what you need faster 2,8 Calculation factor (Y2) by Shandong Jiangshan Industrial Development Co., Ltd. entering your ISO Bearing information .
https://voyagemd.com/iso-51432-bearing/
php - Using require/require once() in a functions file - Stack Overflowphp - Using require/require once() in a functions file - Stack Overflow
on top of the functions.php file, but that does not seem to give my functions access to the variable in settings.php. I need to put require(settings.php) in every function separately.. Is there a way I can declare the variables in settings.php to be accessible globally to all functions defined in functions.php?. Thank you,. ...
https://stackoverflow.com/questions/6022021/using-require-require-once-in-a-functions-file
PHP: Читайте FAQ - ManualPHP: Читайте FAQ - Manual
Некоторые проблемы возникают чаще других. Наиболее часто встречающиеся из них перечислены в разделе PHP FAQ этого руководства. ...
https://www.php.net/manual/ru/install.problems.faq.php
Association of the porcine transforming growth factor beta type i receptor (TGFBR1) gene with growth and carcass traits<...Association of the porcine transforming growth factor beta type i receptor (TGFBR1) gene with growth and carcass traits<...
TY - JOUR. T1 - Association of the porcine transforming growth factor beta type i receptor (TGFBR1) gene with growth and carcass traits. AU - Chen, Kefei. AU - Hawken, Rachel. AU - Flickinger, Gail H.. AU - Rodriguez-Zas, Sandra L.. AU - Rund, Laurie A.. AU - Wheeler, Matthew B.. AU - Abrahamsen, Mitch. AU - Rutherford, Mark S. AU - Beever, Jonathan E.. AU - Schook, Lawrence B.. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Background: Growth and carcass traits are of great economic importance in livestock production. A large number of quantitative trait loci (QTL) have been identified for growth and carcass traits on porcine chromosome one (SSC1). A key positional candidate for this chromosomal region is TGFBR1 (transforming growth factor beta type I receptor). This gene plays a key role in inherited disorders at cardiovascular, craniofacial, neurocognitive, and skeletal development in mammals. Results: In this study, 27 polymorphic SNPs in the porcine TGFBR1 gene were identified on the University of ...
https://experts.umn.edu/en/publications/association-of-the-porcine-transforming-growth-factor-beta-type-i
Gentaur Molecular :Panomics \ C EBPalpha C EBPgamma EMSA Probe Set \ AY1274PGentaur Molecular :Panomics \ C EBPalpha C EBPgamma EMSA Probe Set \ AY1274P
Gentaur molecular products has all kinds of products like :search , Panomics \ C_EBPalpha _ C_EBPgamma EMSA Probe Set \ AY1274P for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=248620&supplier=search&name=C_EBPalpha%20_%20C_EBPgamma%20%20EMSA%20Probe%20Set
News | Estonian Melges 24 Class Association | Page 3
Peaks vist mainima, et laupäeva õhtul oli tormiline Liidu hooajalõpuüritus, kuid hommikuks olid kõik ikkagi vapralt stardis.. Pühapäeval puhusid ida ja kirde tuuled 1-4 ms ja kohtunikud nägid hea raja panemisega kurja vaeva. Päeva algatuseks jällegi Lenny võitis, kuid teises sõidus leidis stardis RockCity mingi imetuule ja kadus pikalt eest ära ning võitis teise sõidu, samas kui Lenny jäeti kolmandaks. regativõit jäi viimasele sõidule, kui Rock City võidab, saab ta ka Lennyst ette.. Viimases sõidus esimese ülemise märgi võttis liidrina Lenny, Freddy ja Rock City ees. Peale alumist märki olid kõik kolm paati koos ja tundus, et Rock City suudab vasakult hanitada. Lenny ja Rock City sõitsid koos vasakule, samas ...
http://melges24.ee/category/news/page/3/
Home | Government of Republic of EstoniaHome | Government of Republic of Estonia
Peaminister külastas reservväelaste õppust Okas 2017. Valitsus kutsus lisaõppekogunemise kokku kolmapäeval, 6.12, välja kutsuti reservväelased 669 ametikoha täitmiseks. Neljapäeval, 7.12 alanud õppus Okas 2017 kestab pühapäeva õhtuni. Tegu on teise korraga, kui Eesti oma reaalset kaitsevõimet sellisel kombel testib. Esimene lisaõppekogunemine toimus 2016. aasta detsembris, mil teenistusse kutsuti üle 300 reservväelase ja kaitseliitlase Põhja- ning Lõuna-Eestis. Video: Kaitsevägi ...
https://www.valitsus.ee/en
TIMKEN 02475/02420 bearing, 68,262x31.75x22,225, 02475/02420 bearing for sale | GBS Bearing
d - 31.75 mm. D - 68,262 mm. T - 22,225 mm. B - 22,225 mm. C - 17,462 mm. R - 3,6 mm. r - 1,5 mm. a - -5,1 mm. Da - 63 mm. db - 44,5 mm. da - 38,5 mm. Db - 59 mm. Aa - 1,2 mm. Ab - 0,9 mm. Weight - 0,37 Kg. Basic static load rating (C0) - 70,2 kN. Factor (G1) - 17,5. Factor (G2) - 8,5. Factor (Cg) - 0,0164. Factor (K) - 1,4. Basic dynamic load rating (C90) - 15,3. Basic dynamic load rating (Ca90) - 10,9. Basic dynamic load rating (C1) - 59,1 kN. Calculation factor (e) - 0,42. Calculation factor (Y) - 1,44. ...
http://www.joycedebacco.com/bearings/TIMKEN-bearing/02475/02420.html
Is PHP pass by reference or pass by value?
Is PHP pass by reference or pass by value? Answer: PHP is pass by value, see the code below: |?php class Dog { public $name; public
http://www.linuxask.com/questions/is-php-pass-by-reference-or-pass-by-value
PHP: get debug type - ManualPHP: get debug type - Manual
の、解決済みの名前を返します。 この関数は、オブジェクトをクラス名に、 リソースをリソース型の名前に、 そしてスカラー型の値を型宣言で使われている通常の名前に解決します。 gettype() は、歴史的な理由で決まった型の名前を返します。 この関数は、それよりも実際に使われている型により近い名前を返すという点が異なります。 ...
https://www.php.net/manual/ja/function.get-debug-type.php
Share this postShare this post
Θα ήθελα να μάθω πως μπορούμε να διαγράψουμε παραγγελίες που έχουμε δημιουργήσει και είναι δοκιμαστικές!! χρειάζεται να επέμβουμε κάπου? η να πειράξουμε php?
https://www.prestashop.com/forums/topic/440126-%CF%80%CF%89%CF%82-%CE%B4%CE%B9%CE%B1%CE%B3%CF%81%CE%AC%CF%86%CE%BF%CF%85%CE%BC%CE%B5-%CF%80%CE%B1%CF%81%CE%B1%CE%B3%CE%B3%CE%B5%CE%BB%CE%AF%CE%B5%CF%82-%CF%80%CE%BF%CF%85-%CE%B5%CE%AF%CE%BD%CE%B1%CE%B9-%CE%B5%CE%AF%CF%84%CE%B5-%CE%B4%CE%BF%CE%BA%CE%B9%CE%BC%CE%B1%CF%83%CF%84%CE%B9%CE%BA%CE%AD%CF%82-%CE%B5%CE%AF%CF%84%CE%B5-%CE%BB%CE%AC%CE%B8%CE%BF%CF%82/
Under pressure: Acute cardiac tamponade<...
TY - JOUR. T1 - Under pressure. T2 - Acute cardiac tamponade. AU - Chen, Leon. PY - 2019/5/1. Y1 - 2019/5/1. UR - http://www.scopus.com/inward/record.url?scp=85065026074&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85065026074&partnerID=8YFLogxK. U2 - 10.1097/01.CCN.0000553086.79399.f0. DO - 10.1097/01.CCN.0000553086.79399.f0. M3 - Article. AN - SCOPUS:85065026074. VL - 14. SP - 35. EP - 37. JO - Nursing Critical Care. JF - Nursing Critical Care. SN - 1558-447X. IS - 3. ER - ...
https://nyu-staging.pure.elsevier.com/en/publications/under-pressure-acute-cardiac-tamponade
interpreting php as plain text when using php function require - Stack Overflowinterpreting php as plain text when using php function require - Stack Overflow
I have main site to which i put code using require function, but when i add php functions into it, they appear as plain text. The php code is rather long so i wont paste it here. Could anyone help me with that?. Thanks ok i am adding some code:. require part with only one function:. ...
https://stackoverflow.com/questions/3382104/interpreting-php-as-plain-text-when-using-php-function-require
19746 (Reference to help sidebar in WP Screen (wp-admin/includes/screen.php)) - WordPress Trac19746 (Reference to help sidebar in WP Screen (wp-admin/includes/screen.php)) - WordPress Trac
I didnt realise, but ​Quercus is a PHP Implementation in Java, so its not a PHP 5.2 thing. If it was a PHP5.2 issue, Id expect many more broken sites, as every admin view would be fataling. Not sure it needs a backport, but doesnt do any harm either. Ill leave it up to nacin to decide what to do there ...
https://core.trac.wordpress.org/ticket/19746
Registry Key Handling Through PHP - CodeProjectRegistry Key Handling Through PHP - CodeProject
This article is basically helpfull in handling Registry Key through PHP code.; Author: amitjha1611; Updated: 10 Jul 2012; Section: PHP; Chapter: Web Development; Updated: 10 Jul 2012
https://www.codeproject.com/Tips/418527/Registry-Key-Handling-Through-PHP?fid=1744994&df=90&mpp=10&noise=3&prof=True&sort=Position&view=None&spc=None
Php output excel utf8 İşleri, İstihdam | FreelancerPhp output excel utf8 İşleri, İstihdam | Freelancer
13 milyon üzerinde projeye sahip dünyanın en büyük serbest çalışma pazarında Php output excel utf8 ile ilgili işler arayın ya da iş verin. Kaydolmak ve işlere teklif vermek ücretsizdir.
https://www.tr.freelancer.com/work/php-output-excel-utf8/
DAB goes green - IER DailyDAB goes green - IER Daily
The ecologic range comprises four new portable models inc-luding the ecologic 1 - available in black or white - which is equipped with a built-in battery charger ...
https://www.ierdaily.co.uk/dab-goes-green/
Marcin Probola: PHP static code analysis vs ~1000 top wordpress plugins = 103 vulnerable plugins found
ได้โดยที่จะทำให้คุณนั้นสามารถสร้างกำไรจากการเล่นเกมส์เดิมพันออนไลน์ได้เราแนะนำเกมส์ชนิดนี้ให้คุณได้รู้จักก็เพราะว่าเชื่อว่าทุกคนนั้นจะต้องรู้วิธีการเล่นและวิธีการเอาชนะเกมม สล็อต ...
http://blog.cinu.pl/2015/11/php-static-code-analysis-vs-top-1000-wordpress-plugins.html?showComment=1584573296378&m=1
CCAAT-enhancer-binding proteinsCCAAT-enhancer-binding proteins
... (or C/EBPs) is a family of transcription factors composed of six members, named from C/EBPα to ... "Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein ... "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". ... CCAAT/enhancer-binding proteins are often involved in growth arrest and differentiation, which has been interpreted to suggest ...
https://en.wikipedia.org/wiki/CCAAT-enhancer-binding_proteins
CAAT boxCAAT box
These proteins are known as CCAAT box binding proteins/CCAAT box binding factors. A CCAAT box is a feature frequently found ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ... "DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y". The Journal of Biological Chemistry. 272 (42): 26562-26572. doi: ... Another aspect of the CCAAT binding motif is the CCAAT/enhancer binding proteins (C/EBPs). They are a group of transcription ...
https://en.wikipedia.org/wiki/CAAT_box
NFIXNFIX
"Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, ... gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression ... for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66-73. doi:10.1006/geno.1995.1107. PMID 7590749 ... Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates ...
https://en.wikipedia.org/wiki/NFIX
NFYANFYA
Mantovani R (October 1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15-27. doi:10.1016/S0378- ... forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. ... chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor". The Journal of ... "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Research. 20 (5): 1087-91. doi:10.1093/ ...
https://en.wikipedia.org/wiki/NFYA
NFYBNFYB
Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15-27. doi:10.1016/S0378-1119(99) ... forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a ... "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Res. 20 (5): 1087-91. doi:10.1093/nar/ ... "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300". J. Biol. Chem. 274 (12): 7623 ...
https://en.wikipedia.org/wiki/NFYB
NFIC (gene)NFIC (gene)
"Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)". Blau J, Xiao H, McCracken S, et al. (1996). "Three ... Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and ... for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66-73. doi:10.1006/geno.1995.1107. PMID 7590749 ... Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene. GRCh38: Ensembl release 89: ENSG00000141905 - ...
https://en.wikipedia.org/wiki/NFIC_(gene)
C8orf48C8orf48
These transcription factors include MAX binding protein and Estrogen-related receptor alpha (secondary DNA binding preference) ... "CEBPE CCAAT/enhancer binding protein epsilon [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-09 ... The transcription factors that act on C8orf48 are presented in Table 1. The majority of the transcription factors are involved ... "E2F1 E2F transcription factor 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-09. "KLF7 ...
https://en.wikipedia.org/wiki/C8orf48
NFYCNFYC
Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/ ... Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15-27. doi:10.1016/S0378-1119(99) ... Martinelli R, Heintz N (1994). "H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor ... "The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y". J. Biol. Chem. 278 ...
https://en.wikipedia.org/wiki/NFYC
Serum response factorSerum response factor
Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ... Serum response factor, also known as SRF, is a transcription factor protein. Serum response factor is a member of the MADS ( ... Serum response factor has been shown to interact with: ASCC3, ATF6, CEBPB, CREB-binding protein, ELK4, GATA4, GTF2F1, GTF2I, ... interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor- ...
https://en.wikipedia.org/wiki/Serum_response_factor
CEBPBCEBPB
Serum response factor, SMARCA2, Sp1 transcription factor, TRIM28, and Zif268. Ccaat-enhancer-binding proteins GRCh38: Ensembl ... Chen GK, Sale S, Tan T, Ermoian RP, Sikic BI (April 2004). "CCAAT/enhancer-binding protein beta (nuclear factor for interleukin ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ... "Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins". Mol. Cell. ...
https://en.wikipedia.org/wiki/CEBPB
CEBPACEBPA
CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. For ... CCAAT/enhancer-binding protein alpha, the transcription factor that is encoded by CEBPA, is very important in the ... One category of mutations prevent CCAAT/enhancer-binding protein alpha DNA binding by altering its COOH-terminal basic leucine ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ...
https://en.wikipedia.org/wiki/CEBPA
DNA damage-inducible transcript 3DNA damage-inducible transcript 3
It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. The protein functions ... eukaryotic initiation factor 2α (eIF2α), and induction of a transcription factor, activation transcription factor 4 (ATF4), ... Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D (April 1996). "Stress-induced binding of the transcriptional factor CHOP ... CHOP also interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 ...
https://en.wikipedia.org/wiki/DNA_damage-inducible_transcript_3
CEBPDCEBPD
"Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/ ... "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". ... CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene. The protein encoded by this ... "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb ...
https://en.wikipedia.org/wiki/CEBPD
CEBPGCEBPG
CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Ccaat-enhancer-binding proteins ... Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site". J. ... CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene. The C/EBP family of ... "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma". Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine- ...
https://en.wikipedia.org/wiki/CEBPG
FAM63AFAM63A
... and Ccaat/enchancer binding proteins. Experimental data reveals that FAM63A expression decreases when the estrogen receptor is ... The promoter region contains a number of transcription factors. Those with high scores include estrogen response elements, TATA ... Promoter and transcription factors for FAM63A. http://www.genomatix.de/?s=23e6b2edc9ca33fe998f299bafe56b99 Estrogen receptor ...
https://en.wikipedia.org/wiki/FAM63A
Jun dimerization proteinJun dimerization protein
Other proteins such as interferon regulatory factor-2-binding protein-1 (IRF2BP1). CCAAT/enhancer-binding protein gamma (C/EBPγ ... It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF- ... and recruits interferon regulatory factor 2 binding protein 1 (IRF2BP1), which acts as an E3 ligase. Phosphorylation of Thr at ... "The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and ...
https://en.wikipedia.org/wiki/Jun_dimerization_protein
TSBP1TSBP1
... transcription is regulated by the binding of many transcription factors to the promoter region. The CCAAT binding protein ... Several of the transcription factors including EH1, NACA, NKX5-2, SIX4, VCR, etc. are involved in developmental pathways. Most ...
https://en.wikipedia.org/wiki/TSBP1
FOXI1FOXI1
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". ... "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain ... This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The ... "The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, ...
https://en.wikipedia.org/wiki/FOXI1
FOXA3FOXA3
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". Mol ... HNF-3G is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... 2009). "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ...
https://en.wikipedia.org/wiki/FOXA3
Antineoplastic resistanceAntineoplastic resistance
IL-6 activates the CCAAT enhancer-binding protein transcription factors which activate MDR1 gene expression (see Alteration of ... MDR1 is activated through NF-κB, a protein complex which acts as a transcription factor. In the rat, an NF-κB binding site is ... This transporter protein is encoded by the MDR1 gene and is also called the ATP-binding cassette (ABC) protein. MDR1 has ... Another line of therapeutics used for treating breast cancer is targeting of kinases like human epidermal growth factor ...
https://en.wikipedia.org/wiki/Antineoplastic_resistance
CUTL1CUTL1
Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2)". J. Biol. Chem. 276 (49): 45780-90. doi: ... the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ... "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein ( ...
https://en.wikipedia.org/wiki/CUTL1
AdipogenesisAdipogenesis
Transcription factors, peroxis proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding proteins (C/EBPs) are main ... T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), GATA2/3, retinoic acid receptor α, and SMAD6/7 don't affect the ... Other pro-adipogenic factors like C/EBPs and Krüppel-like factors (KLFs) have been shown to induce the PPARγ promoter. Moreover ... Adipocyte determination and differentiation factor 1 (ADD1) and sterol regulatory element binding protein 1 (SREBP1) can ...
https://en.wikipedia.org/wiki/Adipogenesis
U7 small nuclear RNAU7 small nuclear RNA
"U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y". ... dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA ... The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future ... Jaeger S, Martin F, Rudinger-Thirion J, Giegé R, Eriani G (2006). "Binding of human SLBP on the 3'-UTR of histone precursor H4- ...
https://en.wikipedia.org/wiki/U7_small_nuclear_RNA
CEBPECEBPE
... granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding ... CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. ... "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul ... The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions ...
https://en.wikipedia.org/wiki/CEBPE
Transmembrane protein 251Transmembrane protein 251
No vertebrate TATA binding protein factors, RNA polymerase transcription factor II B, CCAAT binding factors, or CCAAT enhancer ... The transcription factors with the highest matrix scores include NKX homeodomain factors, GATA-binding factors, two-handed zinc ... Various transcription factors are predicted to bind within the conserved parts of the promoter (upstream regulatory) region, on ... finger, E2F transcription factor, and T-box transcription factors. ...
https://en.wikipedia.org/wiki/Transmembrane_protein_251
DNA replication factor CDT1DNA replication factor CDT1
Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding ... CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a ... The protein encoded by this gene is a key licensing factor in the assembly of pre-replication complexes (pre-RC), which occurs ... Overview of all the structural information available in the PDB for UniProt: Q9H211 (Human DNA replication factor Cdt1) at the ...
https://en.wikipedia.org/wiki/DNA_replication_factor_CDT1
Neutrophil-specific granule deficiencyNeutrophil-specific granule deficiency
CCAAT/enhancer-binding protein epsilon) gene, a transcription factor primarily active in myeloid cells. Almost all patients ... granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding ... Khanna-Gupta A, Sun H, Zibello T, Lee HM, Dahl R, Boxer LA, Berliner N (2007). "Growth factor independence-1 (Gfi-1) plays a ...
https://en.wikipedia.org/wiki/Neutrophil-specific_granule_deficiency
ING2ING2
Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/ ...
https://en.wikipedia.org/wiki/ING2
TMEM128TMEM128
... sequence also contains many binding sites for various transcription factors, including TATA box, CCAAT binding protein ... "Transcription factor binding sites for GXP_149843". "miRDB - MicroRNA Target Prediction Database". www.mirdb.org. Retrieved May ... also known as Growth factor receptor-bound protein 2, which is involved in cell development and signal transduction. BCL2L13, ... Several miRNAs have binding sites on the 3' UTR of TMEM128 including: hsa-miR-300 hsa-miR-188-5p hsa-miR-506-3p hsa-miR-3163 ...
https://en.wikipedia.org/wiki/TMEM128
ATF4ATF4
"Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper ... Hai T, Curran T (May 1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding ... This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein ... cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper ...
https://en.wikipedia.org/wiki/ATF4
PANO1PANO1
General transcription factor IIIA, Stimulating protein 1, CCAAT/enhancer binding protein, GC box elements and HMG box- ... 440 transcription factors were identified within the promoter region. To highlight some of relevance and importance to PANO1: ... PANO1 is also known as Proapoptotic Nucleolar Protein 1, PANO, and Pre-mRNA-splicing Factor CW22-like. PANO1 is located on ... Wilms tumor suppressor, Spermatogenic Zip 1 transcription factor, Signal transducer and activator of transcription, Pleomorphic ...
https://en.wikipedia.org/wiki/PANO1
Esta SterneckEsta Sterneck
Sterneck began to study the functions of CCAAT-enhancer-binding proteins (C/EBP) transcription factors, including their roles ... Esta Sterneck is an Austrian molecular biologist researching the functions of the C/EBPδ][CEBPD transcription factor as tumor ... oncogene cooperation in leukemia cells and revealed their coordinate induction of an essential autocrine growth factor. Her ...
https://en.wikipedia.org/wiki/Esta_Sterneck
PIR (gene)PIR (gene)
Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the ... "Entrez Gene: PIR pirin (iron-binding nuclear protein)". Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; ... 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): ... 2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor". J. Biol. Chem. 279 (2): ...
https://en.wikipedia.org/wiki/PIR_(gene)
Glucocorticoid receptorGlucocorticoid receptor
However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... Boruk M, Savory JG, Haché RJ (November 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated ... DNA-binding domain (DBD) D - hinge region E - ligand-binding domain (LBD) F - C-terminal domain In the absence of hormone, the ... "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the ...
https://en.wikipedia.org/wiki/Glucocorticoid_receptor
Embryonal fyn-associated substrateEmbryonal fyn-associated substrate
Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid ... these tyrosine motifs are bound by the SH2 domains of signaling proteins. Important binding partners for this region include ... Important binding partners for this region include FAK, PTK2B, C3G, PTP-PEST, PTP1B, CIZ, and FRNK. Central "substrate domain" ... All CAS proteins except CASS4 contain a YDYVHL motif within this domain, which is an important binding site for the Src SH2 ...
https://en.wikipedia.org/wiki/Embryonal_fyn-associated_substrate
Unfolded protein responseUnfolded protein response
The activated transcription factor upregulates UPR 'stress genes' by directly binding to stress element promoters in the ... An important example is that the proapoptotic protein CHOP (CCAAT/-enhancer-binding protein homologous protein), is upregulated ... The activated domain is able to activate the transcription factor XBP1(Xbox binding protein) mRNA (the mammalian equivalent of ... ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ...
https://en.wikipedia.org/wiki/Unfolded_protein_response
MicroRNAMicroRNA
Zuo Y, Qiang L, Farmer SR (March 2006). "Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta ... targeting the transcription factor brain-derived neurotrophic factor (BDNF) and ultimately reducing its expression. BDNF plays ... Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the ... and 222 significantly inhibited adipogenesis and repressed induction of the master regulators PPARγ and CCAAT/enhancer-binding ...
https://en.wikipedia.org/wiki/MicroRNA
Proser2Proser2
CCAAT binding factors, HOX-PBX complexes, and C2HC zinc finger transcription factors 13. The SRY gene is the primary factor in ... PROSER2 interacts most strongly with the following transcription factors: Vertebrate TATA binding protein factor, ZF5 POZ ... Although PROSER2's function in humans has not been elucidated, its SARG domain, interacting proteins/transcription factors, and ... with androgens would be controlled by transcription factors in the SOX/SRY-sex/testis determining and related HMG box factors ...
https://en.wikipedia.org/wiki/Proser2
C1orf112C1orf112
Transcription factor assessment indicates many potential TATA-binding protein and CCAAT-enhancer-binding proteins sites, along ... promoter analysis based on transcription factor binding sites". Bioinformatics. 21 (13): 2933-42. doi:10.1093/bioinformatics/ ... Ligand binding sites are predicted by I-TASSER from positions 377 to 530 in Isoform X1. A leucine zipper motif is present in ... indicating that this segment may be aqueous and tightly bound. This mixed charge cluster is only partially conserved across ...
https://en.wikipedia.org/wiki/C1orf112
Collagen, type XI, alpha 1Collagen, type XI, alpha 1
2003). "The transcription factor CCAAT-binding factor CBF/NF-Y regulates the proximal promoter activity in the human alpha 1(XI ...
https://en.wikipedia.org/wiki/Collagen,_type_XI,_alpha_1
Glutamate-rich protein 4Glutamate-rich protein 4
"CCAAT/Enhancer-binding Protein Family Members Recruit the Coactivator CREB-binding Protein and Trigger Its Phosphorylation". ... PMID 26769965.{{cite journal}}: CS1 maint: multiple names: authors list (link) "IGFALS insulin like growth factor binding ... "CCAAT/enhancer-binding proteins: structure, function and regulation". Biochemical Journal. 365 (3): 561-575. doi:10.1042/ ... "TATA-binding proteins". InterPro. Retrieved 6 May 2019. "SRY Gene". Genetics Home Reference. Vihervaara A, Sistonen L (2014). " ...
https://en.wikipedia.org/wiki/Glutamate-rich_protein_4
ENO3ENO3
... which contains recognition motifs for binding transcriptional regulatory factors such as Sp1, activator protein 1 and 2, CCAAT ... and two myocyte-specific enhancer-binding factor 1 boxes. Upstream of the first exon lies a TATA-like box and CpG-rich region, ... TFG-TEC binds to the proximal promoter region of the ENO3 gene. Click on genes, proteins and metabolites below to link to ... This first intron, along with the 5'-flanking region, contains a consensus sequence for muscle-specific regulatory factors that ...
https://en.wikipedia.org/wiki/ENO3
PIAS4PIAS4
"A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy ... Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1. GRCh38: Ensembl release 89: ENSG00000105229 ... Lee PS, Chang C, Liu D, Derynck R (2003). "Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta ... 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J ...
https://en.wikipedia.org/wiki/PIAS4
White adipose tissueWhite adipose tissue
... regulating gene involved in regulation of fatty acid storage and glucose metabolism and members of the CCAAT/enhancer-binding ... of the gene expression is important as they can be indicative of various health issues such as obesity related risk factors ... which are exported into the blood and bound to albumin, and glycerol, which is exported into the blood freely. There is ... protein family, type of transcription factors that promotes gene expression. PPARγ is required for both the adipogenesis and ...
https://en.wikipedia.org/wiki/White_adipose_tissue
TAF1TAF1
"The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to ...
https://en.wikipedia.org/wiki/TAF1
HaematopoiesisHaematopoiesis
... is transcription factor CCAAT-enhancer binding protein α (C/EBPα). Mutations in C/EBPα are associated with acute myeloid ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c- ... Other factors, termed colony-stimulating factors (CSFs), specifically stimulate the production of committed cells. Three CSFs ...
https://en.wikipedia.org/wiki/Haematopoiesis
Galactokinase deficiencyGalactokinase deficiency
... several copies of the binding site for the Sp1 transcription factor and the absence of TATA-box and CCAAT-box motifs typically ...
https://en.wikipedia.org/wiki/Galactokinase_deficiency
Ccdc109bCcdc109b
Twist Subfamily of Class B bHLH Transcription Factors (HAND) CCAAT/Enhance Binding Protein (CEBP) Nuclear Factor of Activated T ... Notable transcription factors that bind CCDC109B include: Fork Head Domain Factors (FKHD) Myeloid Zinc Finger 1 Factors (MZF1) ... CCDC109B has a promoter region that contains sites for transcription factor binding. This promoter region is approximately 500 ... Pleomorphic Adenoma Gene (PLAG) C2H2 Zinc Finger Transcription Factors 2 (ZF02) Vertebrate SMAD Family of Transcription Factors ...
https://en.wikipedia.org/wiki/Ccdc109b
Multiple Epidermal Growth Factor-like Domains 8Multiple Epidermal Growth Factor-like Domains 8
Ccaat/Enhancer Binding Protein Vertebrate TATA binding protein factor CCAAT binding factors Activator-, mediator- and TBP- ... binding sites GATA binding factors Nuclear receptor subfamily 2 factors Octamer binding protein EGR/nerve growth factor induced ... More than one hundred transcription factor binding sites were predicted to be found in the megf8 promoter region through ... Calcium EGF-like domain: Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly ...
https://en.wikipedia.org/wiki/Multiple_Epidermal_Growth_Factor-like_Domains_8
KMT2DKMT2D
For example, CCAAT/enhancer-binding protein β (C/EBPβ), an early adipogenic transcription factor, recruits and requires KMT2D ... Mechanistically, KMT2C and KMT2D are required for the binding of H3K27 acetyltransferases CREB-binding protein (CBP) and/or ... WDR5 binds directly with FYRN/FYRC domains of C-terminal SET domain-containing fragments of human KMT2C and KMT2D. UTX, the ... For p300 to bind the enhancer, the physical presence of KMT2D, and not just the KMT2D-mediated H3K4me1, is required. However, ...
https://en.wikipedia.org/wiki/KMT2D
Transcription factorTranscription factor
Some transcription factors, so-called pioneer factors are still able to bind their DNA binding sites on the nucleosomal DNA. ... Heteromeric CCAAT factors 4.8.1 Family: Heteromeric CCAAT factors 4.9 Class: Grainyhead 4.9.1 Family: Grainyhead 4.10 Class: ... In many cases, a transcription factor needs to compete for binding to its DNA binding site with other transcription factors and ... most transcription factors bind DNA in a sequence specific manner. However, not all bases in the transcription factor-binding ...
https://en.wikipedia.org/wiki/Transcription_factor
Estrogen receptor alphaEstrogen receptor alpha
... is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and ... Boruk M, Savory JG, Haché RJ (November 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ... "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)". Kos M, Reid G, Denger ...
https://en.wikipedia.org/wiki/Estrogen_receptor_alpha
The roles of p38 MAPK and CCAAT/enhancer binding protein beta in the transcriptional regulation of the fibroblast growth factor...The roles of p38 MAPK and CCAAT/enhancer binding protein beta in the transcriptional regulation of the fibroblast growth factor...
The roles of p38 MAPK and CCAAT/enhancer binding protein beta in the transcriptional regulation of the fibroblast growth factor ... Transcriptional roles of CCAAT/enhancer binding protein-b, nuclear factor-kB, and C-promoter binding factor 1 in interleukin ( ... Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, ... Roles of nuclear factors, nuclear factor kB, cAMP response element-binding protein, CCAAT/enhancer-binding protein-b, and ...
https://eurekamag.com/research/035/932/035932203.php
Insulin, CCAAT/Enhancer-Binding Proteins and Lactate Regulate the Human 11β-Hydroxysteroid Dehydrogenase Type 2 Gene Expression...Insulin, CCAAT/Enhancer-Binding Proteins and Lactate Regulate the Human 11β-Hydroxysteroid Dehydrogenase Type 2 Gene Expression...
Pathway analysis using mRNA profiling revealed that insulin treatment modified the expression of the transcription factor ... CCAAT/enhancer-binding proteins) but also of glycolysis related enzymes. Western blot and real time PCR confirmed an ... Transcription factors Is the Subject Area "Transcription factors" applicable to this article? Yes. No. ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105354
MedlinePlus: Genes: CMedlinePlus: Genes: C
CDT1: chromatin licensing and DNA replication factor 1. *CEBPA: CCAAT enhancer binding protein alpha ...
https://medlineplus.gov/genetics/gene-c/
ING2 inhibitor of growth family member 2 [Homo sapiens (human)] - Gene - NCBIING2 inhibitor of growth family member 2 [Homo sapiens (human)] - Gene - NCBI
part_of CCAAT-binding factor complex IDA Inferred from Direct Assay. more info ... ING; Inhibitor of growth proteins N-terminal histone-binding. Alternate T2T-CHM13v2.0. Genomic * NC_060928.1 Alternate T2T- ... ING; Inhibitor of growth proteins N-terminal histone-binding. * NM_001564.4 → NP_001555.1 inhibitor of growth protein 2 isoform ... A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. Temel M, et al. Tumour Biol, 2015 Jun. ...
https://www.ncbi.nlm.nih.gov/gene/3622
DeCS - Termos NovosDeCS - Termos Novos
FATOR DE LIGAÇÃO A CCAAT. CCAAT-BINDING FACTOR. FACTOR DE ENLACE A CCAAT. ... PROTEINA ALFA DE ENLACE AUMENTADORA A CCAAT. PROTEÍNA BETA INTENSIFICADORA DE LIGAÇÃO A CCAAT. CCAAT-ENHANCER-BINDING PROTEIN- ... PROTEÍNAS INTENSIFICADORAS DE LIGAÇÃO A CCAAT. CCAAT-ENHANCER-BINDING PROTEINS. PROTEINAS DE ENLACE AUMENTADORAS A CCAAT. ... TACROLIMUS BINDING PROTEIN 1A. PROTEINA 1A DE ENLACE A TACROLIMUS. PROTEÍNA ALFA INTENSIFICADORA DE LIGAÇÃO A CCAAT. CCAAT- ...
https://decs.bvs.br/P/news2001pie.htm
Determination of functional domains in the C subunit of the CCAAT- binding factor (CBF) necessary for formation of a CBF-DNA...
The mammalian CCAAT-binding factor (CBF; also called NF-Y and CP1) is a heterotrimeric protein consisting of three subunits, ... abstract = "The mammalian CCAAT-binding factor (CBF; also called NF-Y and CP1) is a heterotrimeric protein consisting of three ... N2 - The mammalian CCAAT-binding factor (CBF; also called NF-Y and CP1) is a heterotrimeric protein consisting of three ... AB - The mammalian CCAAT-binding factor (CBF; also called NF-Y and CP1) is a heterotrimeric protein consisting of three ...
https://koreauniv.pure.elsevier.com/en/publications/determination-of-functional-domains-in-the-c-subunit-of-the-ccaat
Frontiers | Primary Vitamin D Target Genes of Human MonocytesFrontiers | Primary Vitamin D Target Genes of Human Monocytes
This includes the 1,25(OH)2D3-modulated cistromes of VDR, the pioneer transcription factors PU.1 and CEBPA and the chromatin ... This includes the 1,25(OH)2D3-modulated cistromes of VDR, the pioneer transcription factors PU.1 and CEBPA and the chromatin ... of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the ... of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the ...
https://www.frontiersin.org/articles/10.3389/fphys.2019.00194/full
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression | Diabetes | American Diabetes AssociationEndoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression | Diabetes | American Diabetes Association
CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue ... Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, and delta genes in fully- ... Our recent genome-wide study of C/EBP and PPARγ binding in adipocytes (33) demonstrated that PPARγ binds near C/EBPα at the ... PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale ...
https://diabetesjournals.org/diabetes/article/58/8/1879/15142/Endoplasmic-Reticulum-Stress-Regulates-Adipocyte
SMART: CBF domain annotationSMART: CBF domain annotation
CCAAT-binding factors A (CBF-A) and B (CBF-B) are two subunits of the heteromeric CCAAT-binding factor. Portions of CBF-A and ... CCAAT-binding factor (CBF) is a heteromeric mammalian transcription factor which binds to sequences containing a CCAAT motif in ... Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [ (PUBMED: ... Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction ...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=CBF&BLAST=DUMMY
Display 100 results per pageDisplay 100 results per page
CCAAT enhancer binding protein (CEBP) transcription factors (TFs) are known to promote adipocyte differentiation; however, ... Uric acid binds to the Na+ binding pocket of the Na+/H+ exchanger protein and inhibits its activity, acidifying the cytoplasm ... Cyclic AMP-responsive element-binding protein H (CREBH encoded by Creb3l3) is a transcription factor that regulates the ... AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid ...
https://www.jbc.org/Metabolism?startPage=0&pageSize=100
Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by...Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by...
... brain derived neurotrophic factor; CHOP: CCAAT/enhancer-binding protein homologous protein; CK-MB: creatine kinase-MB; CFR: ... 5. Hiltunen JO, Laurikainen A, Vakeva A, Meri S, Saarma M. Nerve growth factor and brain-derived neurotrophic factor mRNAs are ... Keywords: ischemia/reperfusion injury, nerve growth factor, endoplasmic reticulum, apoptosis. Introduction. Nerve growth factor ... CCAAT/enhancer-binding protein homologous protein (CHOP), caspase-12, total- and phospho-(Ser473)-Akt were assessed by Western ...
https://www.medsci.org/v12p0083.htm
NFYB Antibody - N-terminal region (ARP38748 P050) | Aviva Systems Biology | Aviva Systems BiologyNFYB Antibody - N-terminal region (ARP38748 P050) | Aviva Systems Biology | Aviva Systems Biology
... forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a ... forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a ... The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. ... The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. ...
https://www.avivasysbio.com/nfyb-antibody-n-terminal-region-arp38748-p050.html
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase - Volume 24, Number 10-October...
A recent study showed that HapE forms a CCAAT binding complex, which plays a role in the negative regulation of cyp51A ... Hagiwara D, Miura D, Shimizu K, Paul S, Ohba A, Gonoi T, et al. A novel zn2-cys6 transcription factor atrr plays a key role in ... Sterol biosynthesis and azole tolerance is governed by the opposing actions of SrbA and the CCAAT binding complex. PLoS Pathog ... Polyene drugs such as amphotericin B and nystatin bind to ergosterol in the plasma membrane, leading to cell death by promoting ...
https://wwwnc.cdc.gov/eid/article/24/10/18-0730
Fluoride Action Network | Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum...Fluoride Action Network | Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum...
... and CCAAT/enhancer-binding protein-homologous protein (CHOP), without affecting total eukaryotic translation initiation factor ... The protein expression levels of apoptosis factors, including Bax, Bcl-2, casepase-3, casepase-9 and cytochrome c, and the mRNA ... Moreover, the antioxidant N-acetylcysteine (NAC) and pro-apoptotic transcription factor CHOP knockdown were used to clarify the ... In addition, NaF exposure facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2 ...
https://fluoridealert.org/studytracker/21771/
KEGG ORTHOLOGY: K09055KEGG ORTHOLOGY: K09055
03000 Transcription factors. K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha. Transcription factors [BR:ko03000]. ... C/EBP-like factors. K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha. ... K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha. 05202 Transcriptional misregulation in cancer. K09055 CEBPA; CCAAT ... K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha. 09167 Endocrine and metabolic disease. 04932 Non-alcoholic fatty ...
https://www.kegg.jp/entry/K09055
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons | Scientific ReportsTDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons | Scientific Reports
TAR DNA-binding protein 43 (TDP-43) is a key player in neurodegenerative diseases including frontotemporal lobar degeneration ( ... TDP-43 was originally identified as a factor binding to the TAR DNA of human immunodeficiency virus where it is implicated in ... CCAAT/enhancer-binding protein homologous protein). CHOP inhibits Bcl2 functions at the protein level and induces Bim to ... Bbc3 binds Bcl2 releasing the proapoptotic BH3-only proteins Bax and Bak. Hence, Bbc3 induced by TDP-43 via p53 could bind and ...
https://www.nature.com/articles/s41598-018-26397-2?error=cookies_not_supported&code=6945d3b7-864f-43a2-aa17-ed2ede71e904
Eukaryotic genomes may exhibit up to 10 generic classes of gene promoters | BMC Genomics | Full TextEukaryotic genomes may exhibit up to 10 generic classes of gene promoters | BMC Genomics | Full Text
... which suggest a possible predisposition for specific levels of gene expression and perhaps for a different number of factors ... Nevertheless, many genes using the same combinatorial formation of transcription factors have different gene expression ... Mantovani R: The molecular biology of the CCAAT-binding factor NF-Y. Gene. 1999, 239: 15-27. 10.1016/S0378-1119(99)00368-6. ... Fashena SJ, Reeves R, Ruddle NH: A poly(dA:dT) upstream activating sequence binds high-mobility group I protein and contributes ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-512
Acute Myeloid Leukemia (AML): Practice Essentials, Pathophysiology, EtiologyAcute Myeloid Leukemia (AML): Practice Essentials, Pathophysiology, Etiology
6] Mutation of CEBPA (the gene encoding CCAAT/enhancer binding protein alpha, a granulocytic differentiation factor and member ... The prognosis depends on several factors. Increasing age is an adverse factor, because older patients more frequently have a ... A high BMI is a risk factor in younger patients with de novo acute myelogenous leukemia. Eur J Haematol. 2015 Aug 16. [QxMD ... The most common risk factor for AML is the presence of an antecedent hematologic disorder, the most common of which is ...
https://www.medscape.com/answers/197802-63216/how-does-acute-myeloid-leukemia-aml-develop-in-patients-exposed-to-chemotherapy-agents
H-InvDB - Transcript view HIT000033286H-InvDB - Transcript view HIT000033286
CCAAT/enhancer-binding protein beta; C/EBP beta; Liver activator protein; Nuclear factor NF-IL6; Transcription factor 5; TCF-5; ...
http://h-invitational.jp/hinv/spsoup/transcript_view?hit_id=HIT000033286&status=motif
Marcia Margis | IntechOpenMarcia Margis | IntechOpen
The Evolutionary History of CBF Transcription Factors: Gene Duplication of CCAAT - Binding Factors NF-Y in Plants By Alexandro ...
https://www.intechopen.com/profiles/53376
C/EBPδ is a crucial regulator of pro-apoptotic gene expression during mammary gland involution | Development | The Company of...C/EBPδ is a crucial regulator of pro-apoptotic gene expression during mammary gland involution | Development | The Company of...
DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J. Biol. Chem. ... Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/ ... CCAAT/enhancer-binding protein delta activates insulin-like growth factor-I gene transcription in osteoblasts. Identification ... Expression of CCAAT/enhancer binding protein delta is closely associated with degeneration of surface mucous cells of larval ...
https://journals.biologists.com/dev/article/132/21/4675/43012/C-EBP-is-a-crucial-regulator-of-pro-apoptotic-gene
IJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor ActivityIJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor Activity
Host mutation in transcription factor expression, or deregulation of their activity in an anaphylaxis context, will be updated ... While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in ... focusing on the transcription factors contributions to this systemic hypersensitivity reaction. ... Other Transcription Factors. The CCAAT-enhancer-binding protein (C/EBP) transcription factor alpha (C/EBPα) plays an important ...
https://www.mdpi.com/1422-0067/22/9/4935/htm
Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer | Orphanet Journal of Rare...Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer | Orphanet Journal of Rare...
Activating transcription factor 4. ATF6:. Activating transcription factor 6. CHOP:. CCAAT-enhancer-binding protein homologous ... Guanine nucleotide binding protein Gsalpha subunit. GRP78(BiP):. Glucose-regulated protein, 78kD/binding immunoglobulin protein ... Bound MUC2 antibody was detected using anti-mouse HRP-conjugated and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid ( ... Briefly, cells were washed twice with cold PBS and then resuspended in 100 μl of 1X Binding Buffer. Five μl of both FITC ...
https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01499-1
Glycogen synthase kinase-3β-mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promotes migration and...
Dive into the research topics of Glycogen synthase kinase-3β-mediated CCAAT/enhancer-binding protein delta phosphorylation in ... Glycogen synthase kinase-3β-mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promotes migration and ...
https://tmu.pure.elsevier.com/en/publications/glycogen-synthase-kinase-3%CE%B2-mediated-ccaatenhancer-binding-protei/fingerprints/
Nitrogen Nutrition, Its Regulation and Biotechnological Approaches to Improve Crop ProductivityNitrogen Nutrition, Its Regulation and Biotechnological Approaches to Improve Crop Productivity
390. Mantovani, R. (1999) The Molecular Biology of the CCAAT-Binding Factor NF-Y. Gene, 239, 15-27. http://dx.doi.org/10.1016/ ... The nitrate binding site is closely bound both extra cellular (TM1-TM2 and TM7-TM8) and intracellular gates (TM4-TM5 and TM10- ... Nitrogen regulated transcription factors, MADS box transcription factor (ANR1), NLP7, LBD37/38/39 proteins, SPL9 and Dof1 are ... NLP7 transcription factor is involved in induction of these genes [85] . Transcription factor, 14-3-3 regulates nitrate ...
https://file.scirp.org/Html/1-2602329_60993.htm
DNA-protein interactions in the CCAAT box region of the murine lactate dehydrogenase C promoter<...
... one of which may be due to a testis specific isoform of CCAAT binding factor (CBF). Southwestern analysis with an ... one of which may be due to a testis specific isoform of CCAAT binding factor (CBF). Southwestern analysis with an ... one of which may be due to a testis specific isoform of CCAAT binding factor (CBF). Southwestern analysis with an ... one of which may be due to a testis specific isoform of CCAAT binding factor (CBF). Southwestern analysis with an ...
https://www.scholars.northwestern.edu/en/publications/dna-protein-interactions-in-the-ccaat-box-region-of-the-murine-la
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotencyDirect reprogramming of terminally differentiated mature B lymphocytes to pluripotency
We utilized transgenic and inducible expression of four transcription factors (O … ... Pluripotent cells can be derived from fibroblasts by ectopic expression of defined transcription factors. A fundamental ... state maintaining B cell identity by either ectopic expression of the myeloid transcription factor CCAAT/enhancer-binding- ... These factors were sufficient to convert nonterminally differentiated B cells to a pluripotent state. However, reprogramming of ...
https://pubmed.ncbi.nlm.nih.gov/18423197/?dopt=Abstract
ZFIN Publication: Bresciani et al., 2014ZFIN Publication: Bresciani et al., 2014
CCAAT-Binding Factor/metabolism. *Core Binding Factor Alpha 2 Subunit/genetics*. *Core Binding Factor Alpha 2 Subunit/ ... CBFβ and RUNX1 form a DNA-binding heterodimer and are both required for hematopoietic stem cell (HSC) generation in mice. ... CCAAT-Binding Factor/genetics*. * ...
https://zfin.org/ZDB-PUB-140523-3
ProteinsPromoterHomologous proteinMammalianGeneCHOPPeroxisomePhosphorylationNuclear factorNucleic acidBrain deriveSequenceAffinityActivatesInterferonComplementPathwayLiverKnockdownLymphocyteSTRESSDIFFERENTIATIONTumorSolubleAcuteErythroidE2F1HematopoiesisElementObesityMutationsNecessary and suffic
Proteins9
  • Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. (embl-heidelberg.de)
  • These include heat shock protein GRP78 (glucose regulated protein 78, also called BiP, immunoglobulin heavy chain-binding protein) and three ER transmembrane proteins PERK (protein kinase activated by double-stranded RNA-like ER kinase), IRE1 (inositol-requiring enzyme 1) and ATF6 (activating transcription factor 6). (biomedcentral.com)
  • These include elevated expression of transcription factor CHOP (C/EBP homologous protein, also called GADD153), inhibition of anti-apoptotic proteins (e.g. (biomedcentral.com)
  • Electrophoretic Mobility (EMSA), using oligonucleotides containing CCAAT box sequences from the murine Idhc promoter show the presence of CCAAT binding proteins in nuclear extracts from liver and testis. (northwestern.edu)
  • These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. (tumorportal.org)
  • Retinoblastoma Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (musc.edu)
  • This graph shows the total number of publications written about "Retinoblastoma Binding Proteins" by people in this website by year, and whether "Retinoblastoma Binding Proteins" was a major or minor topic of these publications. (musc.edu)
  • Below are the most recent publications written about "Retinoblastoma Binding Proteins" by people in Profiles. (musc.edu)
Promoter7
  • This includes the 1,25(OH) 2 D 3 -modulated cistromes of VDR, the pioneer transcription factors PU.1 and CEBPA and the chromatin modifier CTCF as well as of the histone markers of promoter and enhancer regions, H3K4me3 and H3K27ac, respectively. (frontiersin.org)
  • NFYB is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. (avivasysbio.com)
  • protein sequence alignments and experiments with mutants.The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. (avivasysbio.com)
  • The structure of a promoter is recognized by the presence of known promoter elements, such as TATA box, GC-box, CCAAT-box, BRE and INR box[ 4 - 12 ]. (biomedcentral.com)
  • Ambhaikar, M & Goldberg, E 1999, ' DNA-protein interactions in the CCAAT box region of the murine lactate dehydrogenase C promoter ', Molecular reproduction and development , vol. 52, no. 4, pp. 360-365. (northwestern.edu)
  • We show here that such a sequence present in the rat albumin promoter binds a protein distinct from the CCAAT-binding transcription factor CTF/NFI or from the CCAAT-binding protein (CBP) previously described. (pasteur.fr)
  • Upon stress, HSF1 undergoes trimerization, phosphorylation, and activation of DNA binding activity, and activates hsp gene transcription through binding to heat shock elements (HSEs) present in their promoter. (rupress.org)
Homologous protein3
  • The effects of ER stress were transcriptional because of downregulation of CAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ transcriptional activators and upregulation of the transcriptional repressor CAAT/enhancer binding protein homologous protein-10 (CHOP10). (diabetesjournals.org)
  • Myocardial apoptosis rate was measured by TUNEL staining, and expression of glucose-related protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), caspase-12, total- and phospho-(Ser473)-Akt were assessed by Western blot analyses. (medsci.org)
  • and CCAAT/enhancer-binding protein-homologous protein (CHOP), without affecting total eukaryotic translation initiation factor 2? (fluoridealert.org)
Mammalian1
  • Activation of the mammalian heat shock transcription factor (HSF)1 by stress is a multistep process resulting in the transcription of heat shock genes. (rupress.org)
Gene8
  • A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. (nih.gov)
  • The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. (embl-heidelberg.de)
  • Nevertheless, many genes using the same combinatorial formation of transcription factors have different gene expression patterns. (biomedcentral.com)
  • Furthermore, we also noticed the existence of some transitional states between these classes of promoters that may explain certain evolutionary mechanisms, which suggest a possible predisposition for specific levels of gene expression and perhaps for a different number of factors responsible for triggering gene expression. (biomedcentral.com)
  • This work shows that the STAT3 target gene CCAAT/enhancer binding protein delta (C/EBPδ) is a crucial mediator of pro-apoptotic gene expression events in mammary epithelial cells. (biologists.com)
  • Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. (cdc.gov)
  • The mechanisms responsible for the increased adipos- of Patient with ity are changes in gene expression of multiple enzymes and transcription factors by the virus ( 8-15 ). (cdc.gov)
  • CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (cdc.gov)
CHOP1
  • Moreover, the antioxidant N-acetylcysteine (NAC) and pro-apoptotic transcription factor CHOP knockdown were used to clarify the precise interplay between reactive oxygen species (ROS), ER stress and their roles in NaF-induced apoptosis in Sertoli cells. (fluoridealert.org)
Peroxisome2
  • There were decreased protein expression of peroxisome proliferator-activated receptor-γ (PPARγ) (p = 0.0043) and mRNA expression of CCAAT/enhancer-binding protein-α ( C/EBPα ) (p = 0.0307) in RG2 and decreased PPARγ mRNA expression (p = 0.0008) and C/EBPα protein expression (p = 0.0015) in both RG2 and RG1. (animbiosci.org)
  • In vitro studies in two preadipocyte cell lines (3T3-L1, 3T3-F442) suggest that p,p ´-DDT has the ability to alter adipocyte differentiation, and that these effects correlate with changes induced in the expression of C/EBPα (CCAAT/enhancer-binding protein α) and PPARγ (peroxisome proliferator-activated receptor γ), the main transcription factors regulating the adipogenic process ( Moreno-Aliaga and Matsumura 2002 ). (cdc.gov)
Phosphorylation1
  • Meanwhile, excessive NaF triggered ER stress as evidenced by up-regulated glucose-regulated protein 78kDa (GRP78), PKR-like ER kinase (PERK), phosphorylation of eukaryotic translation initiation factor 2? (fluoridealert.org)
Nuclear factor2
  • In addition, NaF exposure facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in Sertoli cells. (fluoridealert.org)
  • Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
Nucleic acid1
  • The RRM-1 is necessary and sufficient for nucleic acid binding to single stranded RNA at GU-rich sequences 6 . (nature.com)
Brain derive1
  • Nerve growth factor (NGF) is one of the representative members of the neurotrophin family, which includes brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5). (medsci.org)
Sequence6
  • It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. (embl-heidelberg.de)
  • It shows a striking sequence similarity with the yeast factor HAP2/3. (embl-heidelberg.de)
  • Portions of CBF-A and CBF-B have a high degree of amino acid sequence identity to segments of the HAP3 and HAP2 subunits of a yeast multimeric transcription factor. (embl-heidelberg.de)
  • Carboxyl-terminal deletions of this segment (or mutations in arginine residues in this carboxyl-terminal part) abolish DNA binding, but do not alter subunit interactions between CBF-A and CBF-B. Mutations in hydrophobic amino acids within the amino-terminal part of the evolutionarily conserved sequence at positions 252-334 result in loss of both DNA binding and subunit interaction activities. (embl-heidelberg.de)
  • Cross-linked immunoprecipitation and RNA sequencing (CLIP-Seq) revealed that TDP-43 can bind thousands of RNAs via a UG-rich consensus sequence in the 3′ untranslated regions of target RNAs 15 , 16 , 17 . (nature.com)
  • The protein binding to the albumin CCAAT sequence (ACF or albumin CCAAT factor) is not exclusive to liver, since we found a protein with identical properties in spleen. (pasteur.fr)
Affinity2
  • The resulting trimer binds to DNA with high specificity and affinity. (avivasysbio.com)
  • The point-mutated Cyp51A has lower binding affinity to azole drugs, causing azole resistance in these strains ( 5 ). (cdc.gov)
Activates1
  • The molecular basis of vitamin D signaling implies that the metabolite 1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) of the secosteroid vitamin D 3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes. (frontiersin.org)
Interferon1
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
Complement2
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
Pathway1
  • Increased expression of nerve growth factor (NGF) has been found in the myocardium suffered from ischemia and reperfusion (I/R). The pro-survival activity of NGF on ischemic heart has been supposed to be mediated by phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. (medsci.org)
Liver1
Knockdown1
  • However, reprogramming of mature B cells required additional interruption with the transcriptional state maintaining B cell identity by either ectopic expression of the myeloid transcription factor CCAAT/enhancer-binding-protein-alpha (C/EBPalpha) or specific knockdown of the B cell transcription factor Pax5. (nih.gov)
Lymphocyte1
  • After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
STRESS2
  • The effects of endoplasmic stress inducers on resistin mRNA and secreted protein levels were examined in differentiated 3T3-L1 adipocytes, focusing on the expression and genomic binding of transcriptional regulators of resistin. (diabetesjournals.org)
  • Wei K, Liu L, Xie F, Hao X, Luo J, Min S. Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by Activation of Phosphatidylinositol 3-Kinase. (medsci.org)
DIFFERENTIATION1
  • Our observations support that repression of regulatory factors promoting differentiation and development results in the inhibition of BAT maturation in fetal perirenal fat during late pregnancy with maternal undernutrition. (animbiosci.org)
Tumor1
  • To maintain the function on energy regulation, adipose tissue produces adipokines, such as adiponectin and leptin, and proinflammatory cytokines, such as tumor necrosis factor- (TNF-) α and interleukin- (IL-) 1 β [ 6 ]. (hindawi.com)
Soluble1
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Acute1
  • Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia. (cdc.gov)
Erythroid1
  • DNA microarray analysis revealed that red cell transcription factors, including GATA-1, GATA-2, erythroid Kruppel-like factor (EKLF), and growth factor independence-1B (Gfi-1b), were down-regulated in CC-4047-treated CD34+ cells, while myeloid transcription factors such as CCAAT/enhancer binding protein-α (C/EBPα), C/EBPδ, and C/EBPϵ were induced. (mdc-berlin.de)
E2F11
  • In addition, mRNA expressions of CyclinA (p = 0.0109), CyclinB (p = 0.0019), CyclinD (p = 0.0015), cyclin-dependent kinase 1 ( CDK1 ) (p = 0.0001), E2F transcription factor 1 ( E2F1 ) (p = 0.0323), E2F4 (p = 0.0101), and E2F5 (p = 0.0018) were lower in RG1 and RG2. (animbiosci.org)
Hematopoiesis1
  • We hypothesized that CCAAT/enhancer-binding protein α (C/EBPα), one of the most studied lineage-specific transcription factors in hematopoiesis, might influence the expression of NKG2D-Ls. (bvsalud.org)
Element2
  • Even though a "CCAAT" box element is localized approximately equal to 80 base pairs upstream of the transcription initiation site in many eukaryotic promoters, it is not recognized by a single ubiquitous transcription factor. (pasteur.fr)
  • Obesity element binding protein 1 and fatty acid synthase. (cdc.gov)
Obesity1
  • It is well known that obesity is a strong risk factor for type 2 diabetes mellitus (T2DM) and cancer, and T2DM is linked to the development of cardiovascular diseases, such as hypertension and atherosclerosis [ 3 , 4 ]. (hindawi.com)
Mutations1
  • Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. (cdc.gov)
Necessary and suffic1
  • A segment of 83 amino acids from residues 252 to 334, which corresponds to the evolutionarily conserved portion of CBF-B, is necessary and sufficient for CBF-A-dependent DNA binding. (embl-heidelberg.de)
MedlinePlus: Genes: C
MedlinePlus: Genes: C (medlineplus.gov)
Frontiers | Primary Vitamin D Target Genes of Human Monocytes
Frontiers | Primary Vitamin D Target Genes of Human Monocytes (frontiersin.org)
Familial acute myeloid leukemia with mutated CEBPA: MedlinePlus Genetics
Familial acute myeloid leukemia with mutated CEBPA: MedlinePlus Genetics (medlineplus.gov)
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression | Diabetes | American Diabetes Association
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression | Diabetes | American Diabetes Association (diabetesjournals.org)
SMART: CBF domain annotation
SMART: CBF domain annotation (smart.embl-heidelberg.de)
NFYB Antibody - N-terminal region (ARP38748_P050) | Aviva Systems Biology | Aviva Systems Biology
NFYB Antibody - N-terminal region (ARP38748_P050) | Aviva Systems Biology | Aviva Systems Biology (avivasysbio.com)
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons | Scientific Reports
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons | Scientific Reports (nature.com)
Eukaryotic genomes may exhibit up to 10 generic classes of gene promoters | BMC Genomics | Full Text
Eukaryotic genomes may exhibit up to 10 generic classes of gene promoters | BMC Genomics | Full Text (bmcgenomics.biomedcentral.com)
Acute Myeloid Leukemia (AML): Practice Essentials, Pathophysiology, Etiology
Acute Myeloid Leukemia (AML): Practice Essentials, Pathophysiology, Etiology (medscape.com)
Le rite de passage du lait humain : de la synthèse dans le sein maternel à l'estomac du bébé
Le rite de passage du lait humain : de la synthèse dans le sein maternel à l'estomac du bébé (lllfrance.org)
IJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor Activity
IJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor Activity (mdpi.com)
Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer | Orphanet Journal of Rare...
Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer | Orphanet Journal of Rare... (ojrd.biomedcentral.com)
Adenovirus 36 DNA in Adipose Tissue of Patient with Unusual Visceral Obesity - Volume 16, Number 5-May 2010 - Emerging...
Adenovirus 36 DNA in Adipose Tissue of Patient with Unusual Visceral Obesity - Volume 16, Number 5-May 2010 - Emerging... (wwwnc.cdc.gov)
(researchgate.net)
Frontiers | A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort
Frontiers | A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort (frontiersin.org)
ZFIN Publication: Bresciani et al., 2014
ZFIN Publication: Bresciani et al., 2014 (zfin.org)
Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER-mitochondria crosstalk in SiHa cells |...
Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER-mitochondria crosstalk in SiHa cells |... (parasitesandvectors.biomedcentral.com)
Frontiers | Chromatin Interaction Responds to Breast Muscle Development and Intramuscular Fat Deposition Between Chinese...
Frontiers | Chromatin Interaction Responds to Breast Muscle Development and Intramuscular Fat Deposition Between Chinese... (frontiersin.org)
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy | Biology...
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy | Biology... (journals.biologists.com)
Search results for: '28600'
Search results for: '28600' (stemcell.com)
Functional Clustering of Genes Influencing Ageing
Functional Clustering of Genes Influencing Ageing (genomics.senescence.info)
Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors | Cardiovascular...
Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors | Cardiovascular... (cardiab.biomedcentral.com)
Mei-Yu Chen - 研究成果 - 國立陽明交通大學研發優勢分析平台
Mei-Yu Chen - 研究成果 - 國立陽明交通大學研發優勢分析平台 (scholar.nycu.edu.tw)
ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis<...
ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis<... (abdn.pure.elsevier.com)
(emedicine.medscape.com)
Effects of maternal undernutrition during late pregnancy on the regulatory factors involved in growth and development in ovine...
Effects of maternal undernutrition during late pregnancy on the regulatory factors involved in growth and development in ovine... (animbiosci.org)
Cell atlas - NFIC - The Human Protein Atlas
Cell atlas - NFIC - The Human Protein Atlas (v17.proteinatlas.org)