A heterotrimeric DNA-binding protein that binds to CCAAT motifs in the promoters of eukaryotic genes. It is composed of three subunits: A, B and C.
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.
Y-box-binding protein 1 was originally identified as a DNA-binding protein that interacts with Y-box PROMOTER REGIONS of MHC CLASS II GENES. It is a highly conserved transcription factor that regulates expression of a wide variety of GENES.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.
A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
A member of the C-EBP protein family of transcription factors. It plays a key role in G0 PHASE mammary EPITHELIAL CELL growth arrest, and it is involved in transcriptional regulation of INTERLEUKIN 1; INTERLEUKIN 6; and TUMOR NECROSIS FACTOR-ALPHA.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Individual's rights to obtain and use information collected or generated by others.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. (1/416)

The ergosterol biosynthetic pathway is a specific branch of the mevalonate pathway. Since the cells requirement for sterols is greater than for isoprenoids, sterol biosynthesis must be regulated independently of isoprenoid biosynthesis. In this study we explored the transcriptional regulation of squalene synthase (ERG9) in Saccharomyces cerevisiae, the first enzyme dedicated to the synthesis of sterols. A mutant search was performed to identify genes that were involved in the regulation of the expression of an ERG9-lacZ promoter fusion. Mutants with phenotypes consistent with known sterol biosynthetic mutations (ERG3, ERG7, ERG24) increased expression of ERG9. In addition, treatment of wild-type cells with the sterol inhibitors zaragozic acid and ketoconazole, which target squalene synthase and the C-14 sterol demethylase respectively, also caused an increase in ERG9 expression. The data also demonstrate that heme mutants increased ERG9 expression while anaerobic conditions decreased expression. Additionally, the heme activator protein transcription factors HAP1 and HAP2/3/4, the yeast activator protein transcription factor yAP-1, and the phospholipid transcription factor complex INO2/4 regulate ERG9 expression. ERG9 expression is decreased in hap1, hap2/3/4, and yap-1 mutants while ino2/4 mutants showed an increase in ERG9 expression. This study demonstrates that ERG9 transcription is regulated by several diverse factors, consistent with the idea that as the first step dedicated to the synthesis of sterols, squalene synthase gene expression and ultimately sterol biosynthesis is highly regulated.  (+info)

Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex. (2/416)

The observation that cyclin B1 protein and mRNAs are down-regulated in terminally differentiated (TD) C2C12 cells, suggested us to investigate the transcriptional regulation of the cyclin B1 gene in these cells. Transfections of cyclin B1 promoter constructs indicate that two CCAAT boxes support cyclin B1 promoter activity in proliferating cells. EMSAs demonstrate that both CCAAT boxes are recognized by the trimeric NF-Y complex in proliferating but not in TD cells. Transfecting a dominant-negative mutant of NF-YA we provide evidence that NF-Y is required for maximal promoter activity. Addition of recombinant NF-YA to TD C2C12 nuclear extracts restores binding activity in vitro, thus indicating that the loss of NF-YA in TD cells is responsible for the lack of the NF-Y binding to the CCAAT boxes. Consistent with this, we found that the NF-YA protein is absent in TD C2C12 cells. In conclusion, our data demonstrate that NF-Y is required for cyclin B1 promoter activity. We also demonstrate that cyclin B1 expression is regulated at the transcriptional level in TD C2C12 cells and that the switch-off of cyclin B1 promoter activity in differentiated cells depends upon the loss of a functional NF-Y complex. In particular the loss of NF-YA protein is most likely responsible for its inactivation.  (+info)

Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays. (3/416)

The yeast SWI/SNF complex is required for the transcription of several yeast genes and has been shown to alter nucleosome structure in an ATP-dependent reaction. In this study, we show that the complex stimulated in vitro transcription from nucleosome templates in an activation domain-dependent manner. Transcription stimulation by SWI/SNF required an activation domain with which it directly interacts. The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts. The similarity of activation domain interactions and transcriptional stimulation between SWI/SNF and the SAGA histone acetyltransferase complex may account for their apparent overlapping functions in vivo.  (+info)

Identification of proteins that interact with NF-YA. (4/416)

We used the yeast two-hybrid system to show that the serum response factor (SRF) and zinc-fingers and homeobox 1 (ZHXI) proteins interact with the A subunit of nuclear factor-Y (NF-YA). GST pulldown assays revealed that both proteins interact specifically with NF-YA in vitro. Amino acids located between 272 and 564, a region that contains two homeodomains, are required for the interaction of ZHX1 with NF-YA. Two different domains of NF-YA, a glutamine-rich region and a serine/threonine-rich region, are necessary for the interactions with ZHX1 and SRF, respectively.  (+info)

A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene. (5/416)

Proper regulation of the human CD34 gene requires a combinatorial action of multiple proximal and long-range, cis elements. This report shows that, like the murine CD34 5' untranslated region (UTR), the corresponding region of the human CD34 gene is necessary for optimal promoter activity. We localized the most critical element of this region to base pairs +48/+75. Through oligonucleotide competition and antibody supershift experiments in electrophoretic mobility shift assays, we found that this sequence contains a binding site (CCAAT box) for the transcription factor NFY (nuclear factor Y), a factor mediating cell type-specific and cell-cycle regulated expression of genes. Mutating this site led to a 5-fold decrease in CD34 promoter activity in transient transfection experiments. Interestingly, NFY binds adjacently to the earlier identified c-myb binding site. Here we show that both binding sites are important for CD34 promoter function: mutating either site alone decreased CD34 promoter-driven reporter gene activity 4-fold. We also show that the integrity of the c-myb binding site is necessary for stabilization of NFY binding to its site. Such cooperation between c-myb, which is expressed in early hematopoietic cells, and NFY, which is expressed in many cell types, might contribute to specific activation of CD34 in stem cells. The CCAAT box motif was also noted in the 5' UTR of the murine CD34 gene, however, NFY did not bind to this region. Thus, our results indicate that the functional similarities between the human and murine CD34 5' UTRs are achieved through different molecular mechanism(s).  (+info)

Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene. (6/416)

5812 base pairs of rat GTP cyclohydrolase I (GTPCH) 5'-flanking region were cloned and sequenced, and the transcription start site was determined for the gene in rat liver. Progressive deletion analysis using transient transfection assays of luciferase reporter constructs defined the core promoter as a highly conserved 142-base pair GC-rich sequence upstream from the cap site. DNase I footprint analysis of this region revealed (5' --> 3') a Sp1/GC box, a noncanonical cAMP-response element (CRE), a CCAAT-box, and an E-box. Transcription from the core promoter in PC12 but not C6 or Rat2 cells was enhanced by incubation with 8-bromo-cyclic AMP. Mutagenesis showed that both the CRE and CCAAT-box independently contribute to basal and cAMP-dependent activity. The combined CRE and CCAAT-box cassette was also found to enhance basal transcription and confer cAMP sensitivity on a heterologous minimal promoter. The addition of the Sp1/GC box sequence to this minimal promoter construct inhibited basal transcription without affecting the cAMP response. EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor (ATF)-4 and CCAAT enhancer-binding protein beta, while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT-box as a complex containing nuclear factor Y. Overexpression of ATF-4 in PC12 cells was found to transactivate the GTPCH promoter response to cAMP. These studies suggest that the elements required for cell type-specific cAMP-dependent enhancement of gene transcription are located along the GTPCH core promoter and include the CRE and adjacent CCAAT-box and the proteins ATF-4, CCAAT enhancer-binding protein beta, and nuclear factor Y.  (+info)

Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. (7/416)

To understand cholesterol-mediated regulation of human fatty acid synthase promoter I, we tested various 5'-deletion constructs of promoter I-luciferase reporter gene constructs in HepG2 cells. The reporter gene constructs that contained only the Sp-1-binding site (nucleotides -82 to -74) and the two tandem sterol regulatory elements (SREs; nucleotides -63 to -46) did not respond to cholesterol. Only the reporter gene constructs containing a nuclear factor-Y (NF-Y) sequence, the CCAAT sequence (nucleotides -90 to -86), an Sp-1 sequence, and the two tandem SREs responded to cholesterol. The NF-Y-binding site, therefore, is essential for cholesterol response. Mutating the SREs or the NF-Y site and inserting 4 bp between the Sp-1- and NF-Y-binding sites both resulted in a minimal cholesterol response of the reporter genes. Electrophoretic mobility-shift assays using anti-SRE-binding protein (SREBP) and anti-NF-Ya antibodies confirmed that these SREs and the NF-Y site bind the respective factors. We also identified a second Sp-1 site located between nucleotides -40 and -30 that can substitute for the mutated Sp-1 site located between nucleotides -82 and -74. The reporter gene expression of the wild-type promoter and the Sp-1 site (nucleotides -82 to -74) mutant promoter was similar when SREBP1a [the N-terminal domain of SREBP (amino acids 1-520)] was constitutively overexpressed, suggesting that Sp-1 recruits SREBP to the SREs. Under the same conditions, an NF-Y site mutation resulted in significant loss of reporter gene expression, suggesting that NF-Y is required to activate the cholesterol response.  (+info)

Redirection of the respiro-fermentative flux distribution in Saccharomyces cerevisiae by overexpression of the transcription factor Hap4p. (8/416)

Reduction of aerobic fermentation on sugars by altering the fermentative/oxidative balance is of significant interest for optimization of industrial production of Saccharomyces cerevisiae. Glucose control of oxidative metabolism in baker's yeast is partly mediated through transcriptional regulation of the Hap4p subunit of the Hap2/3/4/5p transcriptional activator complex. To alleviate glucose repression of oxidative metabolism, we constructed a yeast strain with constitutively elevated levels of Hap4p. Genetic analysis of expression levels of glucose-repressed genes and analysis of respiratory capacity showed that Hap4p overexpression (partly) relieves glucose repression of respiration. Analysis of the physiological properties of the Hap4p overproducer in batch cultures in fermentors (aerobic, glucose excess) has shown that the metabolism of this strain is more oxidative than in the wild-type strain, resulting in a significant reduced ethanol production and improvement of growth rate and a 40% gain in biomass yield. Our results show that modification of one or more transcriptional regulators can be a powerful and a widely applicable tool for redirection of metabolic fluxes in microorganisms.  (+info)

Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.. ...
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Protein complex formation highly depends on the interplay between preorganization and flexibility of involved binding epitopes. The design of epitope mimetics mainly focuses on the stabilization of a particular bioactive conformation often not considering the conformational dynamics. This limits the potential of peptidomimetics in particular when aiming for challenging targets such as transcription factors. Here, we report the first peptide-derived inhibitor of the NF-Y transcription factor by first constraining the conformation of an epitope using the hydrocarbon stapling approach and then fine-tuning its flexibility. In the initial set of constrained peptides, we observed a severe effect of a single non-interacting alpha-methyl group on complex stability. The combination of X-ray and NMR structures as well as isothermal titration calorimetry and CD spectroscopy reveal how this methyl group affects the conformation of the peptide in its bound state. Adaption of the methylation pattern results ...
The genes coding for the A and B subunits of the transcription factor NF-Y are assigned by a combination of in situ hybridization and analysis of somatic cell hybrids and recombinant mouse strains. NF-YA is assigned to human chromosome 6p21 and to mouse chromosome 17. NF-YB is assigned to human chromosome 12 and to mouse chromosome 10.
TransAM NF-YA Kits are DNA-binding ELISAs that quantify activated NF-YA (nuclear factor Y, alpha) using a method that is faster and more sensitive than gelshift, without radioactivity and gels.
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of loci miR156 ND d 1 miR159 MYB and TCP TFs e b 2 miR160 ND d 1 miR162 DICER-LIKE 1 b 1 miR164 ND a 1 miR166 HD-Zip TFs f, h, k h, k, n h, n c 9 miR167 Auxin response factors TFs a, d, f j d a 6 miR168 ARGONAUTE b 1 miR169 CCAAT binding factor and HAP2-like TFs n, p c 3 miR171 SCARECROW-like TFs c, e, f c c, d a 7 miR319 ND a 1 miR395 ATP sulphurylases i, j, k 3 miR396 GRF TFs, rhodenase-like, and kinesin-like protein B b 1 miR397 Laccases and beta-6 tubulin a a 2 miR399 Phosphatase TFs e b, e 3 miR418 ND x x 2 miR420 ND x x x 3 miR441 ND b a, b, c c 5 miR442 ND x x x 3 miR446 ND x x x 3 miR531 ND x x 2 miR535 ND x x x x 4 Total no. [score:1] ...
There is evidence that transcriptional control of topo IIα regulation is important in regulating gene expression at confluence (Isaacs et al., 1996), and under heat-shock conditions (Furukawa et al., 1998). A recent study indicated that transcriptional elements may regulate the cell cycle control of topo IIα expression (Falck et al., 1999). Furthermore, p53 may directly repress the promoter (Sandri et al., 1996b; Wang et al., 1997). The oncogenes ras andmyb have also been demonstrated to act through specific sequences within the topo IIα promoter. Both heat-shock and cell cycle regulation have been demonstrated to act through the ICB1 in the promoter (Falck et al., 1999), whereas confluence-induced down-regulation is regulated through the ICB2. This study confirms that, unlike with cell cycle regulation, the transcription factor NF-Y forms part of the ICB binding complex. There is an alteration in the intensity of the in vitro footprint seen at confluence, although this is not associated with ...
FIG. 4. Effect of site-specific mutations on C/EBP and NF-Y binding activity. Nuclear extracts were prepared from 293T cells overexpressing C/EBP-α or -β. For mock, the cells were transfected by pcDNA. All probes were generated by PCR with 32P-labeled antisense primer and unlabeled sense primers using site-directed mutated plasmids as templates, and purified from the polyacrylamide gel, to equalize the specific activities between probes. A: DNA oligonucleotide sequence of wild and mutated probes used in EMSA. Mutated regions are indicated by lowercase with * with their name. B: EMSA using nuclear extracts of 293T cells overexpression C/EBP-α and C/EBP-β. Wild-type (wt) and mutant (m1, m2, m3, m4, and m5) probes were incubated with 4 μg of indicated nuclear extracts. The bands corresponding to NF-Y, C/EBP-α, and C/EBP-β are marked by arrows. C: Western blot (WB) analysis of C/EBP-α and -β for validating the expression of C/EBP-α and -β. 293T cells were transfected with expression ...
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We previously identified proline-rich protein 11 (PRR11) as a novel cancer-related gene that is implicated in the regulation of cell cycle and tumorigenesis. Our recent study demonstrated that PRR11 and its adjacent gene, kinetochore associated 2 (SKA2), constitute a classic head-to-head gene pair that is coordinately regulated by nuclear factor Y (NF-Y). In the present study, we further show that the PRR11-SKA2 bidirectional transcription unit is an indirect target of the tumor suppressor p53. A luciferase reporter assay revealed that overexpression of wild type p53, but not mutant p53, significantly represses the basal activity and NF-Y mediated transactivation of the PRR11-SKA2 bidirectional promoter ...
Plasmid pTBRII / CEP-Zeo / Hygro from Dr. Bert Vogelsteins lab contains the insert TGF beta type II receptor and is published in Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2412-6. This plasmid is available through Addgene.
Ameerika autospordisari NASCAR on sattunud järjekordse skandaali keskmesse, kui sarja ainsa mustanahalise sõitja Bubba Wallacei garaažist leiti pühapäeval silmus.
TY - JOUR. T1 - NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. AU - Murai-Takeda, Ayano. AU - Shibata, Hirotaka. AU - Kurihara, Isao. AU - Kobayashi, Sakiko. AU - Yokota, Kenichi. AU - Suda, Noriko. AU - Mitsuishi, Yuko. AU - Jo, Rie. AU - Kitagawa, Hirochika. AU - Kato, Shigeaki. AU - Saruta, Takao. AU - Itoh, Hiroshi. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2010/3/12. Y1 - 2010/3/12. N2 - The role of aldosterone has been implicated in the metabolic syndrome and cardiovascular diseases. The biological actions of aldosterone are mediated through mineralocorticoid receptor (MR). Nuclear receptor-mediated gene expression is regulated by dynamic and coordinated recruitment of coactivators and corepressors. To identify new coregulators of the MR, full-length MR was used as bait in yeast two-hybrid screening. Weisolated NF-YC, one of the subunits of heterotrimeric transcription factor NF-Y. Specific interaction between MRand NF-YC was ...
Zwijsen A., Goumans M.J., Lawson K.A., Van Rooijen M.A., Mummery C.L.. Transforming growth factor beta (TGFbeta) regulates the cell cycle and extracellular matrix (ECM) deposition of many cells in vitro. We have analysed chimaeric mouse embryos generated from embryonic stem cells with abnormal receptor expression to study the effect of TGFbeta on these processes in vivo and the consequences for normal development. The binding receptor for TGFbeta, TbetaRII, is first detected in the embryo proper around day 8.5 in the heart. Ectopic expression of TbetaRII from the blastocyst stage onward resulted in an embryonic lethal around 9.5 dpc. Analysis of earlier stages revealed that the primitive streak of TbetaRII chimaeras failed to elongate. Furthermore, although cells passed through the streak and initially formed mesoderm, they tended to accumulate within the streak. These defects temporally and spatially paralleled the expression of the TGFbeta type I receptor, which is first expressed in the node ...
Cytokine signal transduction is essential for normal immune function and controls the quality of responses to a wide variety of microbial infections. Innate and adaptive host responses to virus infections are regulated by autocrine and paracrine cytokine signaling systems. For most cytokines, receptor binding triggers an intracellular signaling cascade involving one or more signal transducer and activator of transcription (STAT) proteins. Diverse cytokine and growth factor signaling pathways produce active STAT transcription factors that specify mRNA induction profiles (26). For example, the alpha and beta interferon (IFN-α/β) family is of primary importance for both innate and adaptive antiviral immunity (reviewed in references 1, 49, and 53). In the innate antiviral system, IFN-α/β initiates a receptor-mediated signaling system that produces an activated STAT1-STAT2-IRF9 heterotrimeric transcription complex known as ISGF3 (27). The ISGF3 complex translocates to the nucleus, where it can ...
Ubiquitous Illin Ness Pdf Download Ubiquitous Illin Ness Pdf Download. Hey Guys, heres my fancy new solo called Ubiquitous Illin-ness from the new tapspace book Violent Tenor Cream played with my new Vic Firth Billy Club .. Landscape Performance Theory, an Introduction No matter how sophisticated you may be, .. NESS . do not have exact Informa tlon ag to the extent of the gamblin . ILLINI HALL May Made Begins Where Your Student Days Ended We are in harmony, .. What IKEA Tells Us About the Business Model of Law Practice . ness and was surprised at the .. Real-time spectrum analysis is used to predict and analyze . Ubiquitous (thank you, Dick .. A METASTABLE AUSTENITE WI!m PLANE STRESS FRACTURE TOUGH-NESS NEAR 500,000 . Download PDF to View . Ubiquitous Low-Cost Functionalized Multi-Walled Carbon .. Infrastructure Awareness . in ubiquitous computing systems in terms of accuracy and . ness model and a design space for Infrastructure Awareness.. The ubiquitous transcription factor NF-Y ...
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注意: PHP 5 では、foreachの実行開始時に内部配列ポインタは、 配列の先頭要素を指すように自動的にリセットされます。 このため、foreachループの前に reset()をコールする必要はありません。 PHP 5 では、foreach は内部の配列ポインタに依存するので、 ループ内で配列ポインタを変更すると予期せぬ振る舞いを引き起こします。 PHP 7 では、foreach は内部の配列ポインタを使わなくなりました。 ...
The biosynthesis of the beta-lactam antibiotic penicillin in the filamentous fungus Aspergillus nidulans is catalyzed by three enzymes that are encoded by the acvA, ipnA, and aatA genes. A variety of cis-acting DNA elements and regulatory factors form a complex regulatory network controlling these beta-lactam biosynthesis genes. Regulators involved include the CCAAT-binding complex AnCF and AnBH1. AnBH1 acts as a repressor of the penicillin biosynthesis gene aatA. Until now, however, little information has been available on the signal transduction cascades leading to the transcription factors. Here we show that inhibition of protein kinase C (Pkc) activity in A. nidulans led to cytoplasmic localization of an AnBH1-enhanced green fluorescent protein (EGFP) fusion protein. Computer analysis of the genome and screening of an A. nidulans gene library revealed that the fungus possesses two putative Pkc-encoding genes, which we designated pkcA and pkcB. Only PkcA showed all the characteristic features ...
Transcription is a process finely regulated by different transcription factors (TFs) which bind regulatory sequences present in gene promoters and allow the precise execution of gene expression programs. Misregulation of such process can lead to different pathologies, including development/differentiation defects, uncontrolled cell growth and cancer. For these reasons it is important to understand the molecular details of the interplay that occurs between different TFs to modulate gene expression. NF-Y, the heterotrimeric complex composed by NF-YA, NF-YB and NF-YC subunits, all required for DNA binding, recognizes the consensus sequence CCAAT, present in about 30% of eukaryotic promoters, at -60/-100 bp from the Transcription Start Site (TSS). One of the most important roles of NF-Y in transcription is to interact synergistically with other TFs to activate, or to repress, gene expression. In this study we focused on the relationship occurring between NF-Y and the TFs MAX, Myc and USF1, which ...
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Expression of NFYA (CBF-B, HAP2, NF-YA) in breast tissue. Antibody staining with HPA050779 and CAB009250 in immunohistochemistry.
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USA president Donald Trump ütles pühapäeval, et Ühendriikides peaks koroonaviiruse surmajuhtude arv tipnema kahe nädala pärast, pikendades samas ka kodus püsimise korraldust.
Некоторые проблемы возникают чаще других. Наиболее часто встречающиеся из них перечислены в разделе PHP FAQ этого руководства. ...
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Peaks vist mainima, et laupäeva õhtul oli tormiline Liidu hooajalõpuüritus, kuid hommikuks olid kõik ikkagi vapralt stardis.. Pühapäeval puhusid ida ja kirde tuuled 1-4 ms ja kohtunikud nägid hea raja panemisega kurja vaeva. Päeva algatuseks jällegi Lenny võitis, kuid teises sõidus leidis stardis RockCity mingi imetuule ja kadus pikalt eest ära ning võitis teise sõidu, samas kui Lenny jäeti kolmandaks. regativõit jäi viimasele sõidule, kui Rock City võidab, saab ta ka Lennyst ette.. Viimases sõidus esimese ülemise märgi võttis liidrina Lenny, Freddy ja Rock City ees. Peale alumist märki olid kõik kolm paati koos ja tundus, et Rock City suudab vasakult hanitada. Lenny ja Rock City sõitsid koos vasakule, samas ...
Peaminister külastas reservväelaste õppust Okas 2017. Valitsus kutsus lisaõppekogunemise kokku kolmapäeval, 6.12, välja kutsuti reservväelased 669 ametikoha täitmiseks. Neljapäeval, 7.12 alanud õppus Okas 2017 kestab pühapäeva õhtuni. Tegu on teise korraga, kui Eesti oma reaalset kaitsevõimet sellisel kombel testib. Esimene lisaõppekogunemine toimus 2016. aasta detsembris, mil teenistusse kutsuti üle 300 reservväelase ja kaitseliitlase Põhja- ning Lõuna-Eestis. Video: Kaitsevägi ...
Is PHP pass by reference or pass by value? Answer: PHP is pass by value, see the code below: |?php class Dog { public $name; public
TY - JOUR. T1 - Under pressure. T2 - Acute cardiac tamponade. AU - Chen, Leon. PY - 2019/5/1. Y1 - 2019/5/1. UR - http://www.scopus.com/inward/record.url?scp=85065026074&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85065026074&partnerID=8YFLogxK. U2 - 10.1097/01.CCN.0000553086.79399.f0. DO - 10.1097/01.CCN.0000553086.79399.f0. M3 - Article. AN - SCOPUS:85065026074. VL - 14. SP - 35. EP - 37. JO - Nursing Critical Care. JF - Nursing Critical Care. SN - 1558-447X. IS - 3. ER - ...
I didnt realise, but ​Quercus is a PHP Implementation in Java, so its not a PHP 5.2 thing. If it was a PHP5.2 issue, Id expect many more broken sites, as every admin view would be fataling. Not sure it needs a backport, but doesnt do any harm either. Ill leave it up to nacin to decide what to do there ...
This article is basically helpfull in handling Registry Key through PHP code.; Author: amitjha1611; Updated: 10 Jul 2012; Section: PHP; Chapter: Web Development; Updated: 10 Jul 2012
13 milyon üzerinde projeye sahip dünyanın en büyük serbest çalışma pazarında Php output excel utf8 ile ilgili işler arayın ya da iş verin. Kaydolmak ve işlere teklif vermek ücretsizdir.
We have isolated a cDNA coding for a novel human protein that we called ICBP90, because it is an Inverted CCAAT box Binding Protein with a calculated size of 89,758 Da. Immunostaining experiments demonstrate that endogenous and overexpressed ICBP90 are located in the nucleus of HeLa and COS-1 cells, respectively. This is consistent with the presence of two potential nuclear localization signals found in the deduced ICBP90 amino acid sequence. No significant homology, except for the PHD finger (Fig. 3) ⇓ and the ubiquitin-like domain, was found with other proteins, some of which are known to be transcription factors. This suggests that ICBP90 may be a member of a new family of nuclear proteins with DNA-binding properties. Consistent with such an idea, recently, a mouse nuclear protein of 781 amino acids (Np95) was sequenced (39) . Np95 shows a 73.7% identity with ICBP90, which is not sufficient to conclude that Np95 is the mouse counterpart of ICBP90. Indeed, differences exist between these two ...
Epithelial ovarian cancer (EOC) makes up about probably the most gynecological malignancy-associated deaths in america. theres a positive correlation Mestranol between expression of EZH2 and NF-YA in EOCs. Large NF-YA expression predicts shorter general survival in EOC individuals Notably. The association of NF-YA using the promoter from the human being gene can be enhanced in […]. ...
etc/php.d/01-ioncube-loader.ini, /etc/php.d/20-bz2.ini, /etc/php.d/20-calendar.ini, /etc/php.d/20-ctype.ini, /etc/php.d/20-curl.ini, /etc/php.d/20-dom.ini, /etc/php.d/20-exif.ini, /etc/php.d/20-fileinfo.ini, /etc/php.d/20-ftp.ini, /etc/php.d/20-gd.ini, /etc/php.d/20-gettext.ini, /etc/php.d/20-gmp.ini, /etc/php.d/20-iconv.ini, /etc/php.d/20-imap.ini, /etc/php.d/20-mbstring.ini, /etc/php.d/20-mcrypt.ini, /etc/php.d/20-mysqlnd.ini, /etc/php.d/20-pdo.ini, /etc/php.d/20-phar.ini, /etc/php.d/20-posix.ini, /etc/php.d/20-shmop.ini, /etc/php.d/20-simplexml.ini, /etc/php.d/20-soap.ini, /etc/php.d/20-sockets.ini, /etc/php.d/20-sqlite3.ini, /etc/php.d/20-sysvmsg.ini, /etc/php.d/20-sysvsem.ini, /etc/php.d/20-sysvshm.ini, /etc/php.d/20-tidy.ini, /etc/php.d/20-tokenizer.ini, /etc/php.d/20-xml.ini, /etc/php.d/20-xmlwriter.ini, /etc/php.d/20-xsl.ini, /etc/php.d/20-zip.ini, /etc/php.d/30-mysql.ini, /etc/php.d/30-mysqli.ini, /etc/php.d/30-pdo_mysql.ini, /etc/php.d/30-pdo_sqlite.ini, /etc/php.d/30-wddx.ini, ...
Hi, Ive seen some real potential for using Dependency Injection, but all of the code I work with is PHP4 only. So, I thought Id see if I could make something work in PHP4. The PHP5 features used by dependency injectors seem to be: interfaces type hints in constructor signature
Hi, Ive seen some real potential for using Dependency Injection, but all of the code I work with is PHP4 only. So, I thought Id see if I could make something work in PHP4. The PHP5 features used by dependency injectors seem to be: interfaces type hints in constructor signature
Answer to the Race Conditions with Ajax and PHP Sessions, AJAX Locking is a PHP class which can be used to lock server side resources to prevent race conditions that may occur when two users want to access the same
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Please note the internal behaviour of PHP that seems to do the reference assignment BEFORE actually copying the variable!!! Thus you get an array containing a (different) recursive array for the last testcase, instead of an array containing an empty array as you could expect ...
I just pruchased CS5 and am trying to view and modify a php file in Split view. The Split. Design and Love Codebuttonds are greted out. I tried
Faithful transcription initiation is critical for accurate gene expression, yet the mechanisms underlying specific transcription start site (TSS) selection in mammals remain unclear. Here, we show that the histone-fold domain protein NF-Y, a ubiquitously expressed transcription factor, controls the fidelity of transcription initiation at gene promoters in mouse embryonic stem cells. We report that NF-Y maintains the region upstream of TSSs in a nucleosome-depleted state while simultaneously protecting this accessible region against aberrant and/or ectopic transcription initiation. We find that loss of NF-Y binding in mammalian cells disrupts the promoter chromatin landscape, leading to nucleosomal encroachment over the canonical TSS. Importantly, this chromatin rearrangement is accompanied by upstream relocation of the transcription pre-initiation complex and ectopic transcription initiation. Further, this phenomenon generates aberrant extended transcripts that undergo translation, disrupting gene
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Semua lirik lagu hasil pencarian lirik lagu besame muco/components/com_extcalendar/cal_popup.php/errors.php merupakan hak cipta atau hak milik dari penyanyi, pengarang, dan label musik yg bersangkutan. Jika Anda tertarik dengan lagu dari kata kunci besame muco/components/com_extcalendar/cal_popup.php/errors.php, Anda bisa beli kaset/CD originalnya atau menggunakan nada sambung pribadi (NSP) untuk mendukung artis penyanyi / band yang bersangkutan. Terima kasih sudah melakukan pencarian lirik lagu besame muco/components/com_extcalendar/cal_popup.php/errors.php.. ...
Complete information for IER5 gene (Protein Coding), Immediate Early Response 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
With the addition of type-checked function return values in PHP 7, we are one step closer to PHP being a gradually-typed language. This RFC proposes to close that gap with the addition of optional type-checked properties, by allowing the use of static type-hints for properties. Given that objects expose two types of public members, methods and properties, with optional type-checking for function arguments already present, and with the addition of type-checking for function return-values in PHP 7, the addition of type-checking for public properties is natural, and makes OOP in PHP fully gradually-typed. The significance of type-checked properties is a given, as demonstrated by its inclusion in Hack, as well as other recent scripting languages, including Typescript, Dart and ActionScript. The need for type-hinting is demonstrated by the widespread use of php-doc, and support for such type-hinting in modern PHP IDEs. The proposed syntax is compatible with that of Hack, and is a natural addition to ...
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ကၽြန္ေတာ္အခု PHP သမားမ်ားအတြက္ အသံုးဝင္မယ္႔ စာအုပ္ေလးတစ္အုပ္ထပ္တင္ေပးလုိက္ပါတယ္။ အသံုးဝင္ပါတယ္။ ဖိုရမ္သမားမ်ားေတာ႔ သိၾကမွာပါ။ သူ႔အတြက္ Lessons ေလးေတြေတာ္ေတာ္ မ်ားမ်ားပါပါ တယ္။ ဖိုင္ဆိုဒ္ကေတာ႔ 14.87 MB ပဲရွိပါတယ္။ ေဆာင္ထားလုိက္ပါဗ်ာ ...
View and download MSF-USAs Annual Reports, Alert quarterly newsletter, briefing papers, transcripts, op-eds, research articles, and more.
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". Mol ... sequence-specific DNA binding. • DNA binding. • transcription factor binding. • protein domain specific binding. • RNA ... transcription factor activity, sequence-specific DNA binding. • transcription regulatory region DNA binding. • ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ...
kinase binding. • GO:0001948 protein binding. • GO:0000975 transcription regulatory region DNA binding. • transcription factor ... CEBPA, C/EBP-alpha, CEBP, CCAAT/enhancer binding protein alpha, CCAAT enhancer binding protein alpha. ... transcription factor binding. • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding. • ... RNA polymerase I regulatory region DNA binding. • DNA binding. • sequence-specific DNA binding. • protein homodimerization ...
In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... CCAAT boxes are common, as they are in many promoters that lack TATA boxes. In addition, the motifs NRF-1, GABPA, YY1, and ... An example is the E-box (sequence CACGTG), which binds transcription factors in the basic helix-loop-helix (bHLH) family (e.g. ... The process is more complicated, and at least seven different factors are necessary for the binding of an RNA polymerase II to ...
transcription factor binding. • RNA polymerase II activating transcription factor binding. • phosphoprotein binding. • kinase ... "Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled ... protein binding. • androgen receptor binding. • identical protein binding. • enzyme binding. • ubiquitin protein ligase binding ... DNA binding. • core promoter binding. • transcription factor activity, sequence-specific DNA binding. • transcription ...
"CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J ... identify dynamic changes in the phosphorylation status of more than 6000 sites after stimulation with epidermal growth factor.[ ... The phosphorylation of glucose can be enhanced by the binding of Fructose-6-phosphate, and lessened by the binding fructose-1- ... Antibodies bind to and detect phosphorylation-induced conformational changes in the protein. Such antibodies are called phospho ...
Some transcription factors, so-called pioneering factors are still able to bind their DNA binding sites on the nucleosomal DNA ... I. constitutively active - present in all cells at all times - general transcription factors, Sp1, NF1, CCAAT ... The DNA sequence that a transcription factor binds to is called a transcription factor-binding site or response element.[55] ... Main article: DNA-binding domain. The portion (domain) of the transcription factor that binds DNA is called its DNA-binding ...
... implication of factor binding in elevated fetal globin expression". Nucleic Acids Res. 18 (17): 5245-53. doi:10.1093/nar/18.17. ... 1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box ... oxygen binding. • heme binding. • metal ion binding. • oxygen transporter activity. • peroxidase activity. • protein binding. • ... haptoglobin binding. • organic acid binding. Cellular component. • hemoglobin complex. • cytosol. • haptoglobin-hemoglobin ...
transcription factor binding. • sequence-specific DNA binding. Cydrannau o'r gell. • CCAAT-binding factor complex. • protein- ... "Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. ". Gene. 1997. PMID ... GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity. • GO:0000980 RNA polymerase II cis- ... GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • ...
March 2001). "Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute ... such as the SRY gene for testis determining factor. Dominance rules for sex-linked gene loci are determined by their behavior ... The enzyme coded for by IA adds an N-acetylgalactosamine to the membrane-bound H antigen. The IB enzyme adds a galactose. The i ... Dominant negative mutations of the transcription factor C/EBPα can cause acute myeloid leukemia.[20] Inherited dominant ...
Sterneck began to study the functions of CCAAT-enhancer-binding proteins (C/EBP) transcription factors, including their roles ... Esta Sterneck is an Austrian molecular biologist researching the functions of the C/EBPδ][CEBPD transcription factor as tumor ... oncogene cooperation in leukemia cells and revealed their coordinate induction of an essential autocrine growth factor. Her ...
These proteins are known as CCAAT box binding proteins/CCAAT box binding factors. A CCAAT box is a feature frequently found ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ... "DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y". The Journal of Biological Chemistry. 272 (42): 26562-26572. doi: ... Another aspect of the CCAAT binding motif is the CCAAT/enhancer binding proteins (C/EBPs). They are a group of transcription ...
CCAAT binding factors, HOX-PBX complexes, and C2HC zinc finger transcription factors 13. The SRY gene is the primary factor in ... PROSER2 interacts most strongly with the following transcription factors: Vertebrate TATA binding protein factor, ZF5 POZ ... Although PROSER2's function in humans has not been elucidated, its SARG domain, interacting proteins/transcription factors, and ... with androgens would be controlled by transcription factors in the SOX/SRY-sex/testis determining and related HMG box factors ...
... is transcription factor CCAAT-enhancer binding protein α (C/EBPα). Mutations in C/EBPα are associated with acute myeloid ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c- ... Other factors, termed colony-stimulating factors (CSFs), specifically stimulate the production of committed cells. Three CSFs ...
... element-binding protein GTP-binding protein Retinaldehyde-binding protein 1 Ccaat-enhancer-binding proteins Androgen-binding ... Insulin-like growth factor-binding protein Methyl-CpG-binding domain protein 2 Growth hormone-binding protein Vitamin D-binding ... binding protein C4b-binding protein Rap GTP-binding protein Calmodulin-binding proteins Iron-binding proteins Thyroxine-binding ... binding protein Nuclear cap-binding protein complex CREB-binding protein Calcium-binding protein Calcium-binding protein 1 S100 ...
"CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J ... growth factors, and cytokines. Binding of a ligand to a monomeric receptor tyrosine kinase stabilizes interactions between two ... ATP-binding cassette transporter Arginine phosphorylation by McsB kinase marks proteins for degradation by a Clp protease. The ... When serine 337 is phosphorylated by protein kinase A in vitro, the DNA binding efficiency of the p50 subunit of NF-κB is ...
... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ... closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen ...
NFYB_HUMAN] Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example ... Nuclear transcription factor Y References *↑ Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani ... Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 ... Here, we report the first peptide-derived inhibitor of the NF-Y transcription factor by first constraining the conformation of ...
Y-box binding protein 1, YBX1, nuclease sensitive element binding protein 1, NSEP1, enhancer factor I subunit A, CCAAT-binding ... enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription ... Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice ... transcription factor I subunit A, DNA-binding protein B, DBPB, Y-box transcription factor, BP-8, CSDA2, CSDB1, MDR-NF1 ...
... n c 9 miR167 Auxin response factors TFs a, d, f j d a 6 miR168 ARGONAUTE b 1 miR169 CCAAT binding factor and HAP2-like TFs n, p ... auxin response factor, CCAAT -binding protein, scarecrow-like protein, APETELA2 protein and MADS box protein (Additional data ... Of the 21 common targets, most were conserved transcription factors for ancient miRNAs, including SQUAMOSA PROMOTER BINDING ... miR160 and miR164 targeted Auxin response factor (ARF) and NAC transcription factor (NAC), respectively (Additional file 11), ...
Ccaat-Binding Factor Science & Technology Genes, Fungal Ccaat-Enhancer-Binding Proteins Sequence Alignment ... AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the ... 246298-aohapb--aohapc-and-aohape--subunits-of-the-aspergillus-oryzae-ccaat-binding-complex--are-functionally-interchangeable- ...
... nuclear factor Y, alpha) using a method that is faster and more sensitive than gelshift, without radioactivity and gels. ... TransAM NF-YA Kits are DNA-binding ELISAs that quantify activated NF-YA ( ... also known as CAAT-box DNA binding protein, subunit A (CBF-A) is a transcription factor that binds to the CCAAT motif of ... dna-binding ELISA for activated NF-YA transcription factor. TransAM® Kits are DNA-binding ELISAs that facilitate the study of ...
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a ... Nuclear factor I/CCAAT box transcription factor trans-activating domain is a negative sensor of cellular stress. Morel, Y., ... Promoter region of the human gene coding for beta-chain of C4b binding protein. Hepatocyte nuclear factor-3 and nuclear factor- ... Synonyms: CCAAT-box-binding transcription factor, CTF, CTF5, NF-I, NF-I/C, ... ...
CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue. ... CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue ... CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue ... CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue ...
... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ... and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse ...
Nuclear Y/CCAAT-box binding factor B subunit NF-YBImported. ,p>Information which has been imported from another database using ... tr,O73744,O73744_XENLA Nuclear Y/CCAAT-box binding factor B subunit NF-YB OS=Xenopus laevis OX=8355 GN=nfyb PE=2 SV=1 ...
Effect of hypoxia on the expression of CCAAT/enhancer-binding protein β and receptor activator of nuclear factor kappa-B ligand ... In this study, the role of hypoxia-inducible factor-1 (HIF-1) signaling in the regulation of CCAAT (cytosine-cytosine-adenosine ... thymidine)/enhancer-binding protein-β (C/EBPβ) and the receptor activator of nuclear factor kappa-B ligand (RANKL) expressions ... macrophage migration inhibitory factor, monocyte chemoattractant protein-1, and macrophage colony-stimulating factor in the ...
SF (steroidogenic factor-1), C/EBPβ (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor ... Functional Cooperation of Simian Virus 40 Promoter Factor 1 and CCAAT/Enhancer-Binding Protein β and δ in Lipopolysaccharide- ... Functional Cooperation of Simian Virus 40 Promoter Factor 1 and CCAAT/Enhancer-Binding Protein β and δ in Lipopolysaccharide- ... Functional Cooperation of Simian Virus 40 Promoter Factor 1 and CCAAT/Enhancer-Binding Protein β and δ in Lipopolysaccharide- ...
CCAAT-binding transcription factor); nuclear factor 1 X-type; NF1A; CCAAT box binding transcription factor; CCAAT-box-binding ... Nuclear factor 1 X type; Nuclear factor 1/X; Nuclear factor I/X; TGGCA binding protein; TGGCA-binding protein; nuclear factor I ... Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. ... transcription factor; CTF; NF-I/X; NF1-X; NF1X; NFI X; NFI-X; NFI/X; NFIX_HUMAN; ...
When we inserted multiple point mutations that mimic changes known to abolish binding of CCAAT-binding factor to CCAAT ... 201 harbors a copy of the sequence CCAAT that is identical to the binding site for the CCAAT-binding transcription factor (30 ... we inserted multiple point mutations that mimic changes known to abolish binding of the CCAAT-binding factor to CCAAT boxes (31 ... A Transcription Factor Cascade Involving Fep1 and the CCAAT-Binding Factor Php4 Regulates Gene Expression in Response to Iron ...
CCAAT/enhancer binding protein-β (C/EBPβ) and NF-E2-related factor-2 (Nrf2) are both involved in the regulation of the genes ... CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN ... CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN ... CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN ...
RecName: Full=CCAAT/enhancer-binding protein delta; Short=C/EBP delta; AltName: Full=Nuclear factor NF-IL6-beta; Short=NF-IL6- ... RecName: Full=CCAAT/enhancer-binding protein delta; Short=C/EBP delta; AltName: ... RecName: Full=CCAAT/enhancer-binding ... The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA ... HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver ...
CCAAT/enhancer binding protein (C/EBP)ε, a member of the leucine zipper family of transcription factors, is expressed primarily ... CCAAT/enhancer binding proteins (C/EBPs) comprise a family of transcription factors that are key regulators of cellular ... Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT enhancer binding protein ε ... Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT enhancer binding protein ε ...
Characterization of a teleost insulin-like growth factor II (IGF-II) gene: Evidence for promoter CCAAT/enhancer-binding protein ... Characterization of a teleost insulin-like growth factor II (IGF-II) gene: Evidence for promoter CCAAT/enhancer-binding protein ... Characterization of a teleost insulin-like growth factor II (IGF-II) gene : Evidence for promoter CCAAT/enhancer-binding ... Here we describe a rainbow trout IGF-II gene with a proximal promoter that contains two CCAAT/enhancer-binding protein (C/EBP) ...
... eukaryotic translation initiation factor (eIF4E), and 4E binding protein. ... Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients J ... Background: Bronchial smooth muscle (BSM) cells of asthmatic patients have an impaired expression of CCAAT/enhancer binding ... CCAAT-Enhancer-Binding Protein-alpha / biosynthesis* * CCAAT-Enhancer-Binding Protein-alpha / immunology ...
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402 ... the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). ... DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl. *DNA-binding transcription factor ... CCAAT/enhancer-binding protein deltaAdd BLAST. 268. Amino acid modifications. Feature key. Position(s). DescriptionActions. ...
CCAAT/enhancer binding protein zeta (mouse, aa620-633) Antibody (internal region), Peptide-affinity purified goat antibody ... CCAAT-binding factor; CCAAT-box-binding transcription factor; CCAAT/enhancer binding protein alpha (C/EBP) related sequence 1; ... AF3887a: CCAAT/enhancer binding protein zeta (mouse) Antibody (C-Term). AF3888a: CCAAT/enhancer binding protein zeta (mouse, ... CCAAT/enhancer binding protein zeta (mouse, aa620-633) Antibody (internal region) is for research use only and not for use in ...
Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ...
CCAAT-enhancer-binding proteins (or C/EBPs) are a family of transcription factors, composed of six members called C/EBP α to C/ ... CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation, J ... This domain is involved in dimerization and DNA binding like other transcription factors of the leucine zipper family like c- ... 1. Ramji, D. P. & Foka P., CCAAT/enhancer-binding proteins: structure, function and regulation, Biochem. J. 365:561-575 (2002). ...
"A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter". Mol Cell Biol. 10 (12): 6709- ... CCAAT/enhancer-binding protein zeta is a protein that in humans is encoded by the CEBPZ gene. CCAAT/enhancer binding protein ... "Cloning and characterization of mouse CCAAT binding factor". Nucleic Acids Res. 24 (6): 1091-8. doi:10.1093/nar/24.6.1091. PMC ... "Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation ...
Compare CCAAT enhancer binding protein alpha ELISA Kits from leading suppliers on Biocompare. View specifications, prices, ... Background: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a rational target... read more ... CCAAT enhancer binding protein alpha ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody- ... C/EBP alpha (CCAAT/Enhancer Binding Protein Alpha) BioAssay™ ELISA Kit (Human) ...
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions ... RecName: Full=CCAAT/enhancer-binding protein epsilon; Short=C/EBP epsilon RecName: Full=CCAAT/enhancer-binding protein epsilon ... RecName: Full=CCAAT/enhancer-binding protein epsilon; Short=C/EBP epsilon. UniProtKB/Swiss-Prot: Q15744.2 ... See the reference protein sequence for CCAAT/enhancer-binding protein epsilon (NP_001796.2). ...
... phosphorylation of eukaryotic initiation factor 2, and increased synthesis of activating transcription factor (ATF) 4 by a ... suggesting that other factors may serve to enhance ATF4 function. ... CCAAT enhancer-binding protein-activating transcription factor ... is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response ... phosphorylation of eukaryotic initiation factor 2, and increased synthesis of activating transcription factor (ATF) 4 by a ...
Regulation of transcription factors belonging to the CCAAT/enhancer binding protein (C/EBP) family. The C/EBP family plays a ... Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein ... The tumour necrosis factor-a-mediated suppression of the CCAAT/enhancer binding protein-a gene transcription in hepatocytes ... Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein ...
These proteins are known as CCAAT box binding proteins/CCAAT box binding factors. A CCAAT box is a feature frequently found ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ... "DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y". The Journal of Biological Chemistry. 272 (42): 26562-26572. doi: ... Another aspect of the CCAAT binding motif is the CCAAT/enhancer binding proteins (C/EBPs). They are a group of transcription ...
CDT1: chromatin licensing and DNA replication factor 1. *CEBPA: CCAAT enhancer binding protein alpha ...
... to tumor escape from host immune surveillance and to cancer progression by production of tumor-promoting soluble factors.... ... Basic fibroblast growth factor. C/EBPβ. CCAAT/enhancer-binding protein beta ... Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells ... Dale DC (2002) Colony-stimulating factors for the management of neutropenia in cancer patients. Drugs 62(Suppl 1):1-15CrossRef ...
CCAAT-Binding Factor / metabolism * CCAAT-Enhancer-Binding Proteins / metabolism * Carbamoyl-Phosphate Synthase (Ammonia) / ... Several transcription factor binding motifs were conserved within the promoter and enhancer regions while a TATA-box motif was ... DNA-protein pull-down assays and chromatin immunoprecipitation confirmed binding of Sp1 and CREB, but not C/EBP in the promoter ...
... with known transcription factor binding sites (16) underlined. Sp1 binding sites are marked as mapped by DNase footprinting (32 ... The two palindromic sequences Pal I and II bound by RBPJκ (11) are marked by inverted arrows. CCAAT and TATAA sequences are ... Specificity of binding was analyzed by measuring the binding activity in total lysates to immobilized biotinylated hairpin ... Transcription factors frequently act both through a DNA-binding domain that localizes the protein to a specific site within the ...
Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide- ... Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide- ... title = "Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in ... Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide- ...
By cancercurehere with Comments Off on The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in ... The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction ... The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic. ... and among the main regulators may be the CCAAT enhancer binding proteins (C/EBP) family. Associates of the grouped family ...