Caveolins
Caveolin 2
Caveolin 3
Caveolin 1
Caveolae
Endocytic/exocytic CELL MEMBRANE STRUCTURES rich in glycosphingolipids, cholesterol, and lipid-anchored membrane proteins that function in ENDOCYTOSIS (potocytosis), transcytosis, and SIGNAL TRANSDUCTION. Caveolae assume various shapes from open pits to closed vesicles. Caveolar coats are composed of CAVEOLINS.
Membrane Microdomains
Membrane Proteins
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Cell Membrane
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Respiratory Therapy
Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.
Respiratory Therapy Department, Hospital
Adenosine
Respiratory Care Units
Receptor, Adenosine A2A
Ralstonia pickettii
Rhabdomyosarcoma
A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
Satellite Cells, Skeletal Muscle
Receptors, Dopamine D4
Receptors, Dopamine D2
Receptors, Dopamine
Glial Fibrillary Acidic Protein
Brain Ischemia
Infarction, Middle Cerebral Artery
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Annexin A5
P-Glycoprotein
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Ovarian Neoplasms
Blotting, Western
Notochord
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
Encyclopedias as Topic
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The dually acylated NH2-terminal domain of gi1alpha is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein alpha subunits in vivo. (1/923)
Here we investigate the molecular mechanisms that govern the targeting of G-protein alpha subunits to the plasma membrane. For this purpose, we used Gi1alpha as a model dually acylated G-protein. We fused full-length Gi1alpha or its extreme NH2-terminal domain (residues 1-32 or 1-122) to green fluorescent protein (GFP) and analyzed the subcellular localization of these fusion proteins. We show that the first 32 amino acids of Gi1alpha are sufficient to target GFP to caveolin-enriched domains of the plasma membrane in vivo, as demonstrated by co-fractionation and co-immunoprecipitation with caveolin-1. Interestingly, when dual acylation of this 32-amino acid domain was blocked by specific point mutations (G2A or C3S), the resulting GFP fusion proteins were localized to the cytoplasm and excluded from caveolin-rich regions. The myristoylated but nonpalmitoylated (C3S) chimera only partially partitioned into caveolin-containing fractions. However, both nonacylated GFP fusions (G2A and C3S) no longer co-immunoprecipitated with caveolin-1. Taken together, these results indicate that lipid modification of the NH2-terminal of Gi1alpha is essential for targeting to its correct destination and interaction with caveolin-1. Also, a caveolin-1 mutant lacking all three palmitoylation sites (C133S, C143S, and C156S) was unable to co-immunoprecipitate these dually acylated GFP-G-protein fusions. Thus, dual acylation of the NH2-terminal domain of Gi1alpha and palmitoylation of caveolin-1 are both required to stabilize and perhaps regulate this reciprocal interaction at the plasma membrane in vivo. Our results provide the first demonstration of a functional role for caveolin-1 palmitoylation in its interaction with signaling molecules. (+info)The Npc1 mutation causes an altered expression of caveolin-1, annexin II and protein kinases and phosphorylation of caveolin-1 and annexin II in murine livers. (2/923)
We have previously demonstrated (1) an increased expression of caveolin-1 in murine heterozygous and homozygous Niemann-Pick type C (NPC) livers, and (2) an increased concentration of unesterified cholesterol in a detergent insoluble caveolae-enriched fraction from homozygous livers. To define further the relationship between caveolin-1 function and the cholesterol trafficking defect in NPC, we examined the expression and distribution of additional caveolar and signal transduction proteins. The expression of annexin II was significantly increased in homozygous liver homogenates and the Triton X-100 insoluble floating fraction (TIFF). Phosphoamino acid analysis of caveolin-1 and annexin II from the homozygous TIFF demonstrated an increase in serine and tyrosine phosphorylation, respectively. To determine the basis for increased phosphorylation of these proteins, the expression and distribution of several protein kinases was examined. The expression of PKCalpha, PKCzeta and pp60-src (protein kinases) were significantly increased in both heterozygous and homozygous liver homogenates, while PKCdelta was increased only in homozygous livers. Of the protein kinases analyzed, only CK IIalpha was significantly enriched in the heterozygous TIFF. Finally, the concentration of diacylglycerol in the homozygous TIFF was significantly increased and this elevation may modulate PKC distribution and function. These results provide additional evidence for involvement of a caveolin-1 containing cellular fraction in the pathophysiology of NPC and also suggest that the Npc1 gene product may directly or indirectly, regulate the expression and distribution of signaling molecules. (+info)Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. (3/923)
Hypercholesterolemia is a central pathogenic factor of endothelial dysfunction caused in part by an impairment of endothelial nitric oxide (NO) production through mechanisms that remain poorly characterized. The activity of the endothelial isoform of NO synthase (eNOS) was recently shown to be modulated by its reciprocal interactions with the stimulatory Ca2+-calmodulin complex and the inhibitory protein caveolin. We examined whether hypercholesterolemia may reduce NO production through alteration of this regulatory equilibrium. Bovine aortic endothelial cells were cultured in the presence of serum obtained from normocholesterolemic (NC) or hypercholesterolemic (HC) human volunteers. Exposure of endothelial cells to the HC serum upregulated caveolin abundance without any measurable effect on eNOS protein levels. This effect of HC serum was associated with an impairment of basal NO release paralleled by an increase in inhibitory caveolin-eNOS complex formation. Similar treatment with HC serum significantly attenuated the NO production stimulated by the calcium ionophore A23187. Accordingly, higher calmodulin levels were required to disrupt the enhanced caveolin-eNOS heterocomplex from HC serum-treated cells. Finally, cell exposure to the low-density lipoprotein (LDL) fraction alone dose-dependently reproduced the inhibition of basal and stimulated NO release, as well as the upregulation of caveolin expression and its heterocomplex formation with eNOS, which were unaffected by cotreatment with antioxidants. Together, our data establish a new mechanism for the cholesterol-induced impairment of NO production through the modulation of caveolin abundance in endothelial cells, a mechanism that may participate in the pathogenesis of endothelial dysfunction and the proatherogenic effects of hypercholesterolemia. (+info)Regulation of G protein-coupled receptor kinases by caveolin. (4/923)
G protein-coupled receptor kinases (GRKs) have been principally characterized by their ability to phosphorylate and desensitize G protein-coupled receptors. However, recent studies suggest that GRKs may have more diverse protein/protein interactions in cells. Based on the identification of a consensus caveolin binding motif within the pleckstrin homology domain of GRK2, we tested the direct binding of purified full-length GRK2 to various glutathione S-transferase-caveolin-1 fusion proteins, and we discovered a specific interaction of GRK2 with the caveolin scaffolding domain. Interestingly, analysis of GRK1 and GRK5, which lack a pleckstrin homology domain, revealed in vitro binding properties similar to those of GRK2. Maltose-binding protein caveolin and glutathione S-transferase-GRK fusion proteins were used to map overlapping regions in the N termini of both GRK2 and GRK5 that appear to mediate conserved GRK/caveolin interactions. In vivo association of GRK2 and caveolin was suggested by co-fractionation of GRK2 with caveolin in A431 and NIH-3T3 cells and was further supported by co-immunoprecipitation of GRK2 and caveolin in COS-1 cells. Functional significance for the GRK/caveolin interaction was demonstrated by the potent inhibition of GRK-mediated phosphorylation of both receptor and peptide substrates by caveolin-1 and -3 scaffolding domain peptides. These data reveal a novel mode for the regulation of GRKs that is likely to play an important role in their cellular function. (+info)Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. (5/923)
We identified CAVEOLIN-1 as a candidate for a tumour suppressor gene mapping to human chromosome 7q31.1. A number of studies suggest that caveolin could function as a tumour suppressor. Expression of caveolin, and in turn the number of caveolae within a cell, are inversely correlated with the transforming ability of numerous oncoproteins, including H-ras, v-abl, and bcr-abl, and caveolin is a major transformation-dependent substrate of v-src. Heterologous expression of caveolin has been shown to abrogate anchorage-independent growth and induce apoptosis in transformed fibroblasts and also to suppress anchorage-independent growth in human mammary carcinoma cells. We have analysed the status and expression of the human CAVEOLIN-1 gene in primary tumours and tumour-derived cell lines. We found no evidence for mutation of CAVEOLIN-1 in human cancers. Additionally, we found that while the first two exons of CAVEOLIN-1 are associated with a CpG island, this is not methylated in either primary tumours or in tumour-derived cell lines in which Caveolin-1 expression is low or undetectable. The level of expression of Caveolin-1 does not correlate with loss of heterozygosity at the CAVEOLIN-1 locus in these same cell lines. Contrary to other published studies, we have shown that CAVEOLIN-1 is not expressed in normal breast ductal epithelial cells in vivo. CAVEOLIN-1 is however highly expressed in breast myoepithelial cells and its expression is retained in tumours derived from breast myoepithelium. Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo. (+info)A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. (6/923)
The assembly of signaling molecules surrounding the integrin family of adhesion receptors remains poorly understood. Recently, the membrane protein caveolin was found in complexes with beta1 integrins. Caveolin binds cholesterol and several signaling molecules potentially linked to integrin function, e.g., Src family kinases, although caveolin has not been directly implicated in integrin-dependent adhesion. Here we report that depletion of caveolin by antisense methodology in kidney 293 cells disrupts the association of Src kinases with beta1 integrins resulting in loss of focal adhesion sites, ligand-induced focal adhesion kinase (FAK) phosphorylation, and adhesion. The nonintegrin urokinase receptor (uPAR) associates with and stabilizes beta1 integrin/caveolin complexes. Depletion of caveolin in uPAR-expressing 293 cells also disrupts uPAR/integrin complexes and uPAR-dependent adhesion. Further, beta1 integrin/caveolin complexes could be disassociated by uPAR-binding peptides in both uPAR-transfected 293 cells and human vascular smooth muscle cells. Disruption of complexes by peptides in intact smooth muscle cells blocks the association of Src family kinases with beta1 integrins and markedly impairs their migration on fibronectin. We conclude that ligand-induced signaling necessary for normal beta1 integrin function requires caveolin and is regulated by uPAR. Caveolin and uPAR may operate within adhesion sites to organize kinase-rich lipid domains in proximity to integrins, promoting efficient signal transduction. (+info)Visualization of caveolin-1, a caveolar marker protein, in living cells using green fluorescent protein (GFP) chimeras. The subcellular distribution of caveolin-1 is modulated by cell-cell contact. (7/923)
Caveolin-1, a suspected tumor suppressor, is a principal protein component of caveolae in vivo. Recently, we have shown that NIH 3T3 cells harboring anti-sense caveolin-1 exhibit a loss of contact inhibition and anchorage-independent growth. These observations may be related to the ability of caveolin-1 expression to positively regulate contact inhibition. In order to understand the postulated role of caveolin-1 in contact inhibition, it will be necessary to follow the distribution of caveolins in living cells in response to a variety of stimuli, such as cell density. Here, we visualize the distribution of caveolin-1 in living normal NIH 3T3 cells by creating GFP-fusion proteins. In many respects, the behavior of these GFP-caveolin-1 fusion proteins is indistinguishable from endogenous caveolin-1. These GFP-caveolin-1 fusion proteins co-fractionated with endogenous caveolin-1 using an established protocol that separates caveolae-derived membranes from the bulk of cellular membranes and cytosolic proteins, and co-localized with endogenous caveolin-2 in vivo as seen by immunofluorescence microscopy. We show here that as NIH 3T3 cells become confluent, the distribution of GFP-caveolin-1 and endogenous caveolin-1 shifts to areas of cell-cell contact, coincident with contact inhibition. However, unlike endogenous caveolin-1, the levels of GFP-caveolin-1 expression are unaffected by changes in cell density, serum starvation, or growth factor stimulation. These results are consistent with the idea that the levels of endogenous caveolin-1 are modulated by either transcriptional or translational control, and that this modulation is separable from density-dependent regulation of the distribution of caveolin-1. These studies provide a new living-model system for elucidating the dynamic mechanisms underlying the density-dependent regulation of the distribution of caveolin-1 and how this relates to contact inhibition. (+info)Tyrosine-phosphorylated caveolin-1: immunolocalization and molecular characterization. (8/923)
Caveolin-1 was discovered as a major substrate for v-Src, but the effect of its tyrosine phosphorylation has not been known. We generated a specific antibody (PY14) to caveolin-1 phosphorylated at tyrosine 14 and studied the significance of the modification. By Western blotting of lysates of v-Src-expressing cells, PY14 recognized not only a 22-kDa band (the position of nonphosphorylated caveolin-1) but bands at 23-24 and 25 kDa. Bands of slower mobility were diminished by dephosphorylation and were also observed for mutant caveolin-1 lacking tyrosine 14. By immunofluorescence microscopy, PY14 did not label normal cells but detected large dots in v-Src-expressing cells. Immunoelectron microscopy revealed that the dots corresponded to aggregated caveolae and/or vesicles of various sizes; besides, the label was observed in intramembrane particle-free areas in the plasma membrane, which appeared to have been formed by fusion of flattened caveolae. A positive reaction with PY14 was found in normal cells after vanadate or pervanadate treatment; it occurred mainly at 22 kDa by Western blotting and was not seen as large dots by immunofluorescence microscopy. Detergent solubility, oligomerization, and association with caveolin-2 were observed similarly for caveolin-1 in normal and v-Src-expressing cells. The results indicate that phosphorylation of caveolin-1 in v-Src-expressing cells occurs at multiple residues and induces flattening, aggregation, and fusion of caveolae and/or caveolae-derived vesicles. (+info)
Caveolins in Cancer Pathogenesis, Prevention and Therapy
Expression of caveolins in RMS tumours. Double immunost | Open-i
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Caveolin-1 as a potential new therapeutic target in multiple myeloma
Quartett - Caveolin 1 1-CA286-05 Caveolins are a family of int...
Buy Generic Erectile Dysfunction tablets
Brain Sciences | Free Full-Text | Forced Exercise Enhances Functional Recovery after Focal Cerebral Ischemia in Spontaneously...
Role of caveolae in the airway<...
Abstract 176: Administration of a Caveolin-1 Mimetic Peptide Rescues the Cardiac and Pulmonary Abnormalities Observed in Cav-1...
Caveolae-associated protein 1
Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse beta(3)-Adrenoceptor
Caveolin-3
Aquaporin-3 in Keratinocytes and Skin: Its Role and Interaction With Phospholipase D2
Gentaur Molecular :Prospecbio \ Mouse Anti Human Caveolin-1 CAV1 \ ant-027
Laboratory of Virology - Charles University
Caveolin-2 is targeted to lipid droplets, a new membrane domain in the cell<...
Gaining Respectability | Circulation Research
Caveolin-2 (phospho Y19)抗体[EPR2220(3)]|Anti-Caveolin-2 (phospho Y19)抗体[EPR2220(3)]
ROLES FOR A NOVEL CAVIN-1/SOCS3 INTERACTION IN REGULATING PRO-INFLAMMATORY IL-6 SIGNALLING AND CAVEOLA STABILITY | Heart
Recent Publication: Keratinocyte Proliferation and Differentiation - CC: Report | communication. information. engagement.
Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae<...
Caveolae Conducting Calcium | Science Signaling
CAVIN2 - Caveolae-associated protein 2 - Homo sapiens (Human) - CAVIN2 gene & protein
Cav2 - Caveolin-2 - Mus musculus (Mouse) - Cav2 gene & protein
Caveolin-1 says NO to permeability | JCB
Plus it
Molecular Vision: Apoptosis of lens epithelial cells induced by high concentration of glucose is associated with a decrease in...
where to get vector overexpressing caveolin-1?: post #1
Caveolin-2 peptide (ab4929) | Abcam
Only a fraction of flotillins was normally noticed in the raft fractions, while the rest was observed in much more dense...
Cavin3 MGI Mouse Gene Detail - MGI:1923422 - caveolae associated 3
Addgene: CAV1-mEGFP
Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes
JCI -
Welcome
The cell. 5. Vesicular traffic. Endocytosis. Atlas of plant and animal histology.
CSF1R | PR109A as an Anti-Inflammatory Receptor
Low Molecular Weight-Protein Tyrosine Phosphatase and Caveolin-1: Interaction and Isoenzyme-Dependent Regulation | IRIS...
Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin. - Zurich Open Repository...
SNU Open Repository and Archive: Modulation of cancer cell growth and progression by Caveolin-1 in the tumor microenvironment
The Role of Caveolae in PECAM-1 Mechanotransduction :: Temple University Electronic Theses and Dissertations
Caveolin-1 (Cav-1) is a 21?kDa protein enriched in caveolae and continues - Role of adrenergic receptors in human coronary...
Flotillins: Signals from a Raft
November 2015 - HourlyBook
Caveolin-1 antibody | acris-antibodies.com
Biogenesis of Caveolae - Research Collection
Rab12 localizes to Shiga toxin-induced plasma membrane invaginations and controls toxin transport.
| DIAL.pr - BOREAL
Caveolae - Wikipedia
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae |...
Adenovirus-Mediated Overexpression of Caveolin-3 Inhibits Rat Cardiomyocyte Hypertrophy | Hypertension
Psych Central - Fatty acids and caveolin-1 are essential in liver regeneration
Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion. - PubMed -...
The proteoglycan-dystrophin complex in genetic cardiomyopathie...
Caveolin
... have developed compensation or redundancy for the functions of caveolins. Caveolins have a paradoxical role in the development ... The caveolins are similar in structure. They all form hairpin loops that are inserted into the cell membrane. Both the C- ... The functions of caveolins are still under intensive investigation. They are best known for their role in the formation of 50- ... In molecular biology, caveolins are a family of integral membrane proteins that are the principal components of caveolae ...
Caveolae
Caveolins associate with some signaling molecules (e.g. eNOS) through their scaffolding domain and so they can regulate their ... The ability of caveolins to oligomerize due to their oligomerization domains is necessary for formation of caveolar endocytic ... Caveolins are synthesized as monomers and transported to the Golgi apparatus. During their subsequent transport through the ... Increased levels of cholesterol and insertion of the scaffolding domains of caveolins into the plasma membrane leads to the ...
Caveolin 3
Couet J, Sargiacomo M, Lisanti MP (November 1997). "Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin ... Couet J, Sargiacomo M, Lisanti MP (1997). "Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding ... Gratton JP, Bernatchez P, Sessa WC (2004). "Caveolae and caveolins in the cardiovascular system". Circ. Res. 94 (11): 1408-17. ...
Epidermal growth factor receptor
Couet J, Sargiacomo M, Lisanti MP (November 1997). "Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin ...
Caveolin 1
Couet J, Sargiacomo M, Lisanti MP (November 1997). "Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin ... Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo". The Journal of Biological Chemistry. 272 ( ...
Romano-Ward syndrome
LQT9 is caused by variants in the membrane structural protein, caveolin-3. Caveolins form specific membrane domains called ...
FLOT2
2006). "Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax". Parasitol. Res. 99 (2): 153-9. doi: ... "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in ...
Caveolin 2
2000). "Characterization of caveolins from human knee joint catilage: expression of caveolin-1, -2, and -3 in chondrocytes and ... 1997). "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero- ... Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo". J. Biol. Chem. UNITED STATES. 272 (46): ... "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in ...
Lipid raft
Caveolins are widely expressed in the brain, micro-vessels of the nervous system, endothelial cells, astrocytes, ... Both types have similar lipid composition (enriched in cholesterol and sphingolipids). Flotillin and caveolins can recruit ...
FLOT1
"Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in ...
Barraquer-Simons syndrome
Human PTRF mutations may cause secondary deficiency of caveolins, resulting in generalized lipodystrophy in association with in ...
Amphiregulin
... expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin". Cancer ...
PTRF
Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as EHD2 and caveolins ...
Frontiers | Caveolae, Caveolins, Cavins, and Endothelial Cell Function: New Insights | Physiology
Caveolins and the more recently discovered cavins are the major protein components of caveolae. When caveolae were discovered, ... The aim of this review is to focus primarily on molecular and cellular aspects of the role of caveolae, caveolins, and cavins ... The aim of this review is to focus primarily on molecular and cellular aspects of the role of caveolae, caveolins, and cavins ... Caveolins and the more recently discovered cavins are the major protein components of caveolae. When caveolae were discovered, ...
Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. |...
Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. J ... Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. ... Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. ...
Volatile Anesthetics Protect Cancer Cells against Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis via...
Importantly, we have shown that protection in both the neuronal and cardiac system is caveolin-dependent.17 - 20 Caveolins are ... Caveolins, structural proteins found in caveolae, serve as scaffolds and regulators of signaling proteins, including G-proteins ... these data implicate caveolins as an essential component in the temporal and spatial organization of cardiac-protective ... Caveolins. Anesthesiology 9 2011, Vol.115, 499-508. doi:10.1097/ALN.0b013e3182276d42 ...
Actin depolymerization regulates caveolins and cavins a | Open-i
Actin depolymerization regulates caveolins and cavins at the mRNA level in human coronary artery smooth muscle cells.Cells were ... pone.0133931.g002: Actin depolymerization regulates caveolins and cavins at the mRNA level in human coronary artery smooth ... pone.0133931.g002: Actin depolymerization regulates caveolins and cavins at the mRNA level in human coronary artery smooth ... Formation of caveolae requires caveolins and cavins. The make-up of caveolae and their density is considered to reflect cell- ...
Respiratory Therapy Cave: 'Olins: Part 3
Effect. To a nerve cell, Keepmeawakeolin looks like a coffee molecule which looks like adenosine. It then is allowed to attach to adenosine receptors, thus preventing adenosine from attaching to them. So instead of adenosine slowing you down so you can sleep, Keepmeawakeolin keeps you awake. Adenosine dilates blood vessels in the brain, presumably to keep your brain well oxygenated while you are sleeping and your breathing is more relaxed. Keepmealiveolin mimics this effect, thus causing vasodilation of the vessels in the brain to assure adequate oxygenation while you are not sleeping. A side effect of this is that it may cause a headache, which is where caffeine comes in handy. About three hours after dosing, keepmealiveolin starts to dissolve, opening up just enough adenosine receptors for caffeine to attach. This should be enough, however, to constrict brain vessels, thus ridding you of your headache. Still, once the rest of the keepmealiveoline molecules dissipate, the next dose should be ...
Caveolins and macrophage lipid metabolism<...
Caveolins and macrophage lipid metabolism. / Gargalovic, Peter; Dory, Ladislav.. In: Journal of Lipid Research, Vol. 44, No. 1 ... Since caveolins have been implicated in the regulation of cellular cholesterol metabolism in several cell types, it is of ... Caveolins and macrophage lipid metabolism. In: Journal of Lipid Research. 2003 ; Vol. 44, No. 1. pp. 11-21. ... Since caveolins have been implicated in the regulation of cellular cholesterol metabolism in several cell types, it is of ...
Caveolins And Caveolae Roles In Signaling And Disease Mechanisms 2012
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Expression of caveolins in RMS tumours. Double immunost | Open-i
Expression of caveolins in RMS tumours. Double immunostain showing that in skeletal muscle Cav-1 and Cav-3 mark satellite cells ... Bottom Line: Caveolins are scaffolding proteins that play a pivotal role in numerous processes, including caveolae biogenesis, ... Bottom Line: Caveolins are scaffolding proteins that play a pivotal role in numerous processes, including caveolae biogenesis, ... Mentions: Validation of caveolins expression in RMS has drawn the attention only recently. In a large screening of different ...
Caveolins And Caveolae: Roles In Signaling And Disease Mechanisms 2012
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Quartett - Caveolin 1 1-CA286-05 Caveolins are a family of int...
Caveolins have been implicated in both tumor suppression and oncogenesis. High expression of caveolins leads to inhibition of ... Caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in ... However, certain cancer cells that express caveolins have been shown to be more aggressive and metastatic. ...
Caveolins in Cancer Pathogenesis, Prevention and Therapy
It also studies the role of Caveolin-3 in breast cancer.Caveolins are important structural proteins of Caveolae, small ... Caveolins play an important role in the pathogenesis of multiple cancers. This volume focuses mainly on the importance of ... www.MOLUNA.de Caveolins in Cancer Pathogenesis, Prevention and Therapy [4196990] - ... Caveolins and Brain Cancer.- Caveolins and Skin Cancer.- Caveolins and Tumor Angiogenesis.- Caveolins and Tumor Stroma.-. 1. ...
Brain Sciences | Free Full-Text | Forced Exercise Enhances Functional Recovery after Focal Cerebral Ischemia in Spontaneously...
Expression of caveolins was decreased in MCAo brain tissue, whereas the levels of iNOS and glial fibrillary acidic protein ( ... reperfusion and examined expression of caveolins, inflammatory activation markers, and mediators of autophagic cell death. We ... To investigate whether changed expression of caveolins has a pivotal role in focal cerebral ischemia, we induced middle ... functional recovery following cerebral ischemia through caveolin-dependent mechanisms or interactions between caveolins and ...
Advancing Drug Discovery for Schizophrenia | The New York Academy of Sciences
Caveolin - Wikipedia
Caveolins are found in the majority of adherent, mammalian cells. *Caveolin-1 is most prominently expressed in endothelial, ... The caveolins are similar in structure. They all form hairpin loops that are inserted into the cell membrane. Both the C- ... Caveolins have a paradoxical role in the development of this disease. They have been implicated in both tumor suppression and ... Caveolins are thought to play an important role during the development of atherosclerosis.[5] Furthermore, caveolin-3 has been ...
A detergent-insoluble membrance compartment contains Aβ in vivo | Nature Medicine
Category:Integral membrane proteins - Wikimedia Commons
Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle -...
Here, using promoter reporter assays we found that both MKL1/MRTF-A and MKL2/MRTF-B control caveolins and cavins via their ... Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle. ... HomeResearch Outputs Similar regulatory mechanisms of caveolins and cavins by myo... ... these findings further support the view that myocardin family coactivators are important transcriptional drivers of caveolins ...
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta...
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells
Differential expression of caveolins and myosin heavy chains in response to forced exercise in rats | Laboratory Animal...
It is not currently known what changes in the expression of caveolins and types of muscle fiber occur in response to the ... Animals , Caveolin 3 , Caveolins , Female , Humans , Male , Muscle, Skeletal , Muscles , Muscular Atrophy , Myosin Heavy Chains ... This study determined the changes in expression of caveolins and MHC type after forced exercise in muscular and non-muscular ... Differential expression of caveolins and myosin heavy chains in response to forced exercise in rats / 한국실험동물학회지 ...
Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult...
Lipid Raft Proteins and Their Identification in T Lymphocytes | SpringerLink
Caveola | definition of caveola by Medical dictionary
CAV2 | Cancer Genetics Web
Caveolins have recently attracted attention for their possible involvement in signal transduction. Their role in cancer is ... Caveolae are ω-shaped membrane sub-domains that are composed of scaffold proteins named caveolins (i.e., caveolin-1, caveolin-2 ... A reduction in cell adhesion was observed in ∆Np73β overexpressing cells, again supporting a possible role of caveolins in ...
Lipid rafts, caveolae, caveolin-1, and entry by Chlamydiae into host cells.
A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces...
Among the many signaling molecules associated with caveolins ar ... Caveolins are membrane proteins that are the major coat ... Caveolins are membrane proteins that are the major coat proteins of caveolae, specialized lipid rafts in the plasma membrane ... Caveolins / genetics*, metabolism. Cells, Cultured. Membrane Microdomains / metabolism. Mice. Microscopy, Fluorescence. Muscle ... Among the many signaling molecules associated with caveolins are the Src tyrosine kinases, whose activation regulates numerous ...
Caveolae - Wikipedia
Caveolins associate with some signaling molecules (e.g. eNOS) through their scaffolding domain and so they can regulate their ... The ability of caveolins to oligomerize due to their oligomerization domains is necessary for formation of caveolar endocytic ... Caveolins are synthesized as monomers and transported to the Golgi apparatus. During their subsequent transport through the ... Increased levels of cholesterol and insertion of the scaffolding domains of caveolins into the plasma membrane leads to the ...
JCI -
α1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice
Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells | JCB
The newly synthesized caveolins were monomeric (Fig. 6 A, fractions 2 and 3), but a sizeable fraction had already oligomerized ... Specialized Complexes of Caveolins Exist in the Apical and Basolateral Traffic Routes. These data demonstrate that the newly ... One of the aims of this work was to analyze the changes taking place in the physical state of the caveolins during their ... Based on these results we envisage caveolins-1 and -2 to participate in the two post-Golgi membrane traffic routes in MDCK ...
Proteins13
- Caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis. (quartett.com)
- Caveolins are important structural proteins of Caveolae, small invaginations of the membrane. (moluna.de)
- Caveolins are membrane proteins that are the major coat proteins of caveolae, specialized lipid rafts in the plasma membrane that serve as scaffolding sites for many signaling complexes. (biomedsearch.com)
- Caveolins may differentially regulate GPCR signaling by scaffolding and partitioning different receptors, G proteins and their effectors in caveolae. (aspetjournals.org)
- Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signalling molecules. (ebi.ac.uk)
- Caveolins are proteins of about 20 Kd, they form high molecular mass homo-oligomers. (ebi.ac.uk)
- 1-4 Caveolins are major structural proteins of caveolar membranes. (ahajournals.org)
- Caveolae are plasma membrane specializations that contain the structural proteins caveolins, and appear to be important for normal signal transduction. (biologists.org)
- Caveolins, the structural proteins found in caveolae, serve as scaffolds and regulators of signaling proteins. (ahajournals.org)
- 2. Caveolins are a family of integral membrane proteins. (biology-online.org)
- Caveolins are small membrane proteins (22 kD) that can associate to form high molecular mass proteins. (thermofisher.com)
- Two classes of proteins help form caveolae: Caveolins and Cavins. (pubmedcentralcanada.ca)
- Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane. (semanticscholar.org)
Cavins9
- Caveolins and the more recently discovered cavins are the major protein components of caveolae. (frontiersin.org)
- The aim of this review is to focus primarily on molecular and cellular aspects of the role of caveolae, caveolins, and cavins in endothelial cell signaling and function. (frontiersin.org)
- Formation of caveolae requires caveolins and cavins. (nih.gov)
- The make-up of caveolae and their density is considered to reflect cell-specific transcriptional control mechanisms for caveolins and cavins, but knowledge regarding regulation of caveolae genes is incomplete. (nih.gov)
- Using human coronary artery smooth muscle cells we found that jasplakinolide and latrunculin B (LatB), substances that promote and inhibit actin polymerization, increased and decreased protein levels of caveolins and cavins, respectively. (nih.gov)
- Home Research Outputs Similar regulatory mechanisms of caveolins and cavins by myo. (lu.se)
- Here, using promoter reporter assays we found that both MKL1/MRTF-A and MKL2/MRTF-B control caveolins and cavins via their proximal promoter sequences. (lu.se)
- In all, these findings further support the view that myocardin family coactivators are important transcriptional drivers of caveolins and cavins in smooth muscle. (lu.se)
- Particular areas are the study of cholesterol enriched plasmalemmal microdomains, caveolins, cavins, and downstream pathways. (yale.edu)
Caveolae and Caveolins3
- Parton, R.G. Caveolae and caveolins. (nature.com)
- In other tissue types, caveolae and caveolins have been shown to be critical in the coordination of signalling mechanisms at both the plasma membrane and internal structures, such as the sarco/endoplasmic reticulum [ 4 , 5 ]. (ersjournals.com)
- The main features of caveolae and caveolins. (asmblog.org)
Signaling molecules4
- These results suggest that forced exercise may be beneficial for promoting functional recovery following cerebral ischemia through caveolin-dependent mechanisms or interactions between caveolins and these signaling molecules in ischemic brain regions. (mdpi.com)
- Among the many signaling molecules associated with caveolins are the Src tyrosine kinases, whose activation regulates numerous cellular functions including the balance between cell survival and cell death. (biomedsearch.com)
- Caveolins associate with some signaling molecules (e.g. eNOS) through their scaffolding domain and so they can regulate their signaling. (wikipedia.org)
- 6 Many signaling molecules compartmentalize within caveolae and interact with the scaffolding domain of caveolins. (ahajournals.org)
Metabolism2
- Since caveolins have been implicated in the regulation of cellular cholesterol metabolism in several cell types, it is of interest to examine their potential function in macrophages. (unthsc.edu)
- In this review, we attempt to summarize current knowledge and views on the role of caveolins in cholesterol metabolism with emphasis on macrophages. (unthsc.edu)
Membrane5
- 17 - 20 Caveolins are structural components of caveolae, which are small membrane invaginations also enriched in glycosphingolipids and cholesterol. (asahq.org)
- We provide evidence that the two caveolins can form homo- and heterooligomeric complexes in the ER, and that these complexes are modified during transport to the plasma membrane. (rupress.org)
- Increased levels of cholesterol and insertion of the scaffolding domains of caveolins into the plasma membrane leads to the expansion of the caveolar invagination and the formation of endocytic vesicles. (wikipedia.org)
- To test the hypothesis that membrane cholesterol plays a role in cell survival in PCa cells, we used LNCaP human PCa cells that do not express caveolins. (aacrjournals.org)
- It is suggested that lipid rafts/caveolae are sites that remove Gα s from membrane signaling cascades and caveolins might dampen globally Gα s /adenylyl cyclase/cAMP signaling. (aspetjournals.org)
Lipid1
- During their subsequent transport through the secretory pathway, caveolins associate with lipid rafts and form oligomers (14-16 molecules). (wikipedia.org)
Tumor3
- Caveolins have been implicated in both tumor suppression and oncogenesis. (quartett.com)
- Caveolins and Tumor Angiogenesis. (moluna.de)
- Caveolins and Tumor Stroma. (moluna.de)
Cells6
- Although caveolins are ubiquitously expressed, the majority of the available information comes from differentiated cells rich in caveolins, such as fibroblasts, adipocytes, and endothelial cells. (unthsc.edu)
- However, certain cancer cells that express caveolins have been shown to be more aggressive and metastatic. (quartett.com)
- Caveolins are found in the majority of adherent , mammalian cells. (wikipedia.org)
- Cells that lack caveolins also lack caveolae. (wikipedia.org)
- However, certain cancer cells that express caveolins have been shown to be more aggressive and metastatic , because of a potential for anchorage-independent growth. (wikipedia.org)
- We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. (rupress.org)
Pivotal role1
- To investigate whether changed expression of caveolins has a pivotal role in focal cerebral ischemia, we induced middle cerebral artery occlusion (MCAo)-reperfusion and examined expression of caveolins, inflammatory activation markers, and mediators of autophagic cell death. (mdpi.com)
Protein1
- Expression of caveolins was decreased in MCAo brain tissue, whereas the levels of iNOS and glial fibrillary acidic protein (GFAP) increased. (mdpi.com)
Genes2
- Deletion and mutation of genes that encode caveolins is implicated in the pathogenesis of several human diseases. (biologists.org)
- The researchers introduced the caveolin-1 gene (or those genes for other caveolins in further studies) into a standard plasmid expression vector and transformed it into E. coli . (asmblog.org)
Prostate cancer1
- Caveolins and Prostate Cancer. (moluna.de)
Tyrosine1
- 1997 ). Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. (biologists.org)
Pathophysiology1
- Here, we investigate the involvement of caveolins in the pathophysiology of Alzheimer's disease (AD). (jneurosci.org)
Muscular2
- Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. (harvard.edu)
- This study determined the changes in expression of caveolins and MHC type after forced exercise in muscular and non-muscular tissues in rats . (bvsalud.org)
Expression5
- Expression of caveolins in RMS tumours. (nih.gov)
- Validation of caveolins expression in RMS has drawn the attention only recently. (nih.gov)
- To further substantiate the in vivo findings, the expression of caveolins has been analysed in vitro [23]. (nih.gov)
- High expression of caveolins leads to inhibition of cancer-related pathways, such as growth factor signaling pathways. (quartett.com)
- It is not currently known what changes in the expression of caveolins and types of muscle fiber occur in response to the intensity of exercise . (bvsalud.org)
Influential1
- Naringin is caveolins and caveolae roles in signaling and tablet and also is Influential movement. (nolanadams.com)
Pathogenesis1
- Caveolins play an important role in the pathogenesis of multiple cancers. (moluna.de)
Mechanisms11
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Roles12
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Mice3
- Genetically engineered mice that lack caveolin-1 and caveolin-2 are viable and fertile, showing that neither the caveolins nor the caveolae are essential in embryonic development or reproduction of these animals. (wikipedia.org)
- Mice lacking caveolins also suffer from impaired angiogenic responses as well as abnormal responses to vasoconstrictive stimuli. (wikipedia.org)
- In zebrafish , lack of caveolins leads to embryonic lethality , suggesting that higher vertebrates (as exemplified by mice) have developed compensation or redundancy for the functions of caveolins. (wikipedia.org)
Role2
- Caveolins have a paradoxical role in the development of this disease. (wikipedia.org)
- Caveolins are thought to play an important role during the development of atherosclerosis. (wikipedia.org)
Oligomerization1
- The ability of caveolins to oligomerize due to their oligomerization domains is necessary for formation of caveolar endocytic vesicles. (wikipedia.org)
Form1
- These oligomerized caveolins form the caveolae. (wikipedia.org)
Cell1
- An E. coli cell replete with caveolins. (asmblog.org)
Small1
- This many black caveolins registration of standing, start and mar lost Verified in sharepoint with our small steel structures. (nolanadams.com)
Family1
- Caveolin 1 1-CA286-05 Caveolins are a family of int. (quartett.com)
Access1
- Buy your caveolins and as you would access it to watch. (nolanadams.com)
Activation1
- Another signaling pathway utilized by integrin for MAPK activation is via integrin association with caveolins. (thermofisher.com)
Similar1
- The caveolins are similar in structure. (wikipedia.org)