Onchocerca volvulus: A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.Onchocerca: A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum.Onchocerciasis: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.Simuliidae: Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.Ivermectin: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.Intestinal Volvulus: A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.Microfilaria: The prelarval stage of Filarioidea in the blood and other tissues of mammals and birds. They are removed from these hosts by blood-sucking insects in which they metamorphose into mature larvae.Onchocerciasis, Ocular: Filarial infection of the eyes transmitted from person to person by bites of Onchocerca volvulus-infected black flies. The microfilariae of Onchocerca are thus deposited beneath the skin. They migrate through various tissues including the eye. Those persons infected have impaired vision and up to 20% are blind. The incidence of eye lesions has been reported to be as high as 30% in Central America and parts of Africa.Antigens, Helminth: Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.Filaricides: Pharmacological agents destructive to nematodes in the superfamily Filarioidea.DNA, Helminth: Deoxyribonucleic acid that makes up the genetic material of helminths.Mansonelliasis: Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.Loa: A genus of parasitic nematodes found throughout the rain-forest areas of the Sudan and the basin of the Congo. L. loa inhabits the subcutaneous tissues, which it traverses freely.Antibodies, Helminth: Immunoglobulins produced in a response to HELMINTH ANTIGENS.Helminth Proteins: Proteins found in any species of helminth.Cameroon: A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.Skin Diseases, Parasitic: Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.Filarioidea: A superfamily of nematodes of the suborder SPIRURINA. Its organisms possess a filiform body and a mouth surrounded by papillae.Antiparasitic Agents: Drugs used to treat or prevent parasitic infections.Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Dipetalonema: A filarial nematode parasite of mammalian blood with the vector being a tick or small fly.Mansonella: A genus of parasitic nematodes whose organisms are distributed in Central and South America. Characteristics include a smooth cuticle and an enlarged anterior end.Wolbachia: A genus of bacteria comprised of a heterogenous group of gram-negative small rods and coccoid forms associated with arthropods. (From Bergey's Manual of Systematic Bacteriology, vol 1, 1984)Loiasis: A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.GuatemalaTogo: A republic in western Africa, lying between GHANA on its west and BENIN on its east. Its capital is Lome.EcuadorAntinematodal Agents: Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.Liberia: A republic in western Africa, south of GUINEA and east of COTE D'IVOIRE. Its capital is Monrovia.Keratitis: Inflammation of the cornea.Filariasis: Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.Brugia malayi: A species of parasitic nematode causing Malayan filariasis and having a distribution centering roughly on the Malay peninsula. The life cycle of B. malayi is similar to that of WUCHERERIA BANCROFTI, except that in most areas the principal mosquito vectors belong to the genus Mansonia.Guinea: A republic in western Africa, south of SENEGAL and MALI, east of GUINEA-BISSAU. Its capital is Conakry.Setaria Nematode: A genus of parasitic nematodes found in the peritoneal cavity of wild or domestic cattle or equines.Wuchereria bancrofti: A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.Africa, Western: The geographical area of Africa comprising BENIN; BURKINA FASO; COTE D'IVOIRE; GAMBIA; GHANA; GUINEA; GUINEA-BISSAU; LIBERIA; MALI; MAURITANIA; NIGER; NIGERIA; SENEGAL; SIERRA LEONE; and TOGO.Insect Vectors: Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Insect Control: The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Cecal Diseases: Pathological developments in the CECUM.Larva: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.MexicoIntestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.Ghana: A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.Endemic Diseases: The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)Interleukin-5: A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Democratic Republic of the Congo: A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.Graft vs Host Reaction: An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.Cathepsin G: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Onchocerca volvulus Opisthorchiasis Opisthorchis viverrini and Opisthorchis felineus Paracoccidioidomycosis (South American ...
... with a relatively high level of infection by the parasitic worm Onchocerca volvulus, the causative agent of river blindness. ... "The Effects of Drugs on Onchocerca volvulus: 4. Trials of Melarsonyl Potassium". World Health Organization Bulletin. 42 (1): ...
Life cycle of the nematode Onchocerca volvulus.. Parasitic life cycles occur in a variety of forms, all involving the ...
Onchocerca ochengi, the closest relative of O. volvulus, lives in intradermal cavities in cattle, and is also spread by black ... 2010). "Lack of Onchocerca volvulus transmission in the northern focus in Chiapas". Am. J. Trop. Med. Hyg. 83 (1): 15-20. doi: ... Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (June 2007). "Prevalence and intensity of Onchocerca volvulus ... Onchocerciasis, also known as river blindness, is a disease caused by infection with the parasitic worm Onchocerca volvulus. ...
Examination of skin snips will identify microfilariae of Onchocerca volvulus and M. streptocerca. Skin snips can be obtained ... Additionally, to differentiate the skin-dwelling filariae M. streptocerca and Onchocerca volvulus, a nested polymerase chain ... "The morphological discrimination of microfilariae of Onchocerca volvulus from Mansonella ozzardi". Parasitology. 127 (Pt 1): 21 ...
Babesiosis Malaria Onchocerca volvulus Trichomonas Herd immunity Adaptive immune system "Effects of impregnated bednets". ... ISBN 978-3-662-00226-1. Duke, BO (1968). "Reinfections with Onchocerca volvulus in cured patients exposed to continuing ...
The other two are Mansonella streptocerca and Onchocerca volvulus (causes river blindness). Maturing larvae and adults of the " ... and Onchocerca volvulus in rain forest villages of Cameroon. (2003). Medical Microbiology & Immunology, 192(1), 15-21. Manego, ...
... yet unlike other Black flies these species are not carriers of Onchocerca volvulus. Schütt, Brigitta, Thiemann, Stefan, Kulfo ...
... shares considerable antigenic homology with the human filarial worm Onchocerca volvulus; this allows ...
Onchocerca volvulus] is involved in some way, but it is a little puzzling because [the worm] is fairly common in areas that do ... "We could not establish any hint that Onchocerca volvulus is actually going into the brain, but what we cannot exclude is that ... but it is believed to be connected to infestations of the parasitic worm Onchocerca volvulus, which is prevalent in all ... "Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus". Science Translational Medicine. 9 ( ...
... the Onchocerca volvulus, Necator americanus, Wuchereria bancrofti and Dracunculus medinensis are human parasites. Some of ...
... double-blind study of moxidectin in Onchocerca volvulus infection". PLOS Neglected Tropical Diseases. 8 (6): e2953. doi:10.1371 ...
Irvine M, Huima T, Prince AM, Lustigman S (May 1994). "Identification and characterization of an Onchocerca volvulus cDNA clone ... and an Onchocerca volvulus antigen. Goetinck S, Waterston RH (October 1994). "The Caenorhabditis elegans muscle-affecting gene ...
"Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis". The Lancet. Infectious ...
The other two filarial nematodes are Loa loa (the African eye worm), and Onchocerca volvulus (river blindness). The worm is ... or ocular infections like that of Onchocerca volvulus. Due to the absence of nodules, differentiating between M. streptocerca ...
Onchocerca volvulus infection promotes immunosuppressive processes within the human host that suppress immunity against ... Because O. volvulus microfilariae require at least seven days to mature into infective L3 larvae in the black fly, the worm ...
M. ozzardi is usually smaller than those Onchocerca Volvulus (that causes human onchocerciasis) when both species co-exist; ... Characterization of Nuclear Ribosomal DNA Sequences from Onchocera volvulus and Mansonella ozzardi (Nematoda: Filarioidea) and ... volvulus co-occur, skin biopsies have always showed that onchoserciasis is the cause for corneal lesions. Microscopic ...
Black flies are central to the transmission of the parasitic nematode Onchocerca volvulus which causes onchocerciasis, or " ...
Onchocerca volvulus causes cutaneous onchocerciasis and river blindness The other three are less seriously pathogenic but ...
It is caused by the nematode Onchocerca volvulus, which is transmitted to people via the bite of a black fly. Elimination of ...
An extract of the stem bark proved to be toxic to microfilariae of Onchocerca volvulus, the cause of River blindness. "Raphia ...
Onchocerca volvulus manifests itself in the eyes, causing "river blindness" (onchocerciasis), one of the leading causes of ...
Onchocerca volvulus, which causes river blindness, (Onchocerciasis). At the time, the disease was causing widespread blindness ...
Duke BO, Marty AM, Peett DL, Gardo J, Pion SD, Kamgno J, Boussinesq M. Neoplastic change in Onchocerca volvulus and its ... Marty in developing various infectious disease conferences and in identifying unusual effects caused in the female Onchocerca ...
Ov-FAR-1, which is produced by the riverblindness parasite Onchocerca volvulus binds retinol with great affinity, and this ...
Onchocerca volvulus *Onchocerciasis. *Loa loa *Loa loa filariasis. *Mansonella *Mansonelliasis. *Dirofilaria repens ...
Filarial species detected by direct methods were Mansonella perstans (n = 13), Loa loa (n = 4), and Onchocerca volvulus (n = 1 ... Of these, 258 were Onchocerca volvulus infections, 124 were Mansonella perstans infections, 29 were Loa loa infections, and 7 ...
Onchocerca volvulus is a nematode that causes onchocerciasis (river blindness), and is the second-leading cause of blindness ... Neafie, R.C. (1972). "Morphology of Onchocerca volvulus". American Journal of Clinical Pathology. 57 (5): 574-586. doi:10.1093/ ... Duke, B.O. (1993). "The population dynamics of Onchocerca volvulus in the human host". Tropical Medicine and Parasitology. 44 ( ... Unnasch, Thomas R; Williams, S.A. (2000). "The genomes of Onchocerca volvulus". International Journal for Parasitology. 30 (4 ...
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Light micrograph of a section through a skin nodule of a patient with onchocerciasis or river blindness (Onchocerca worm ... Caption: Onchocerca volvulus parasitic worms. Light micrograph of a section through a skin nodule of a patient with ... onchocerca volvulus, onchocerciasis, parasite, parasitic, reproductive, river blindness, section, skin, worm, worms, zoology ... onchocerciasis or river blindness (Onchocerca worm infestation). A longitudinal section of an adult worm is seen across centre ...
Onchocerca volvulus; antibodies; diagnosis; OV16 testing; microfilariae; epilepsy onchocerciasis; Onchocerca volvulus; ... Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo by An Hotterbeekx 1,*. , Jolien ... "Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo." Pathogens 9, no. 6: 435. ... Comparison of Diagnostic Tests for Onchocerca volvulus in the Democratic Republic of Congo. Pathogens 2020, 9, 435. ...
Neutrophil granule proteins: evidence for the participation in the host reaction to skin microfilariae of Onchocerca volvulus ... The participation of neutrophil granulocytes in the cellular reaction to skin microfilariae of Onchocerca volvulus was studied ... volvulus after topical DEC administration. The association between these processes and the damage of the microfilariae ... indicated that neutrophils together with eosinophils attack and damage microfilariae of O. volvulus after DEC treatment in the ...
... View/. Open. Full Text (‎347.8Kb)‎ ... Duke, B. O. (‎1968)‎. Reinfections with Onchocerca volvulus in cured patients exposed to continuing transmission.. Bulletin of ...
In the second patient, who also had leprosy and hyperinfection strongyloidiasis, we found an encapsulated adult O. volvulus in ... elephantiasis who died following diethylcarbamazine therapy there were large numbers of microfilariae of Onchocerca volvulus in ... Onchocerciasis: Invasion of Deep Organs by Onchocerca Volvulus Autopsy Findings* * Wayne M. Meyers, Ronald C. Neafie, Daniel H ... In the second patient, who also had leprosy and hyperinfection strongyloidiasis, we found an encapsulated adult O. volvulus in ...
... volvulus were found in 4 flies of this species. Our findings suggest that O. volvulus may occasionally be transmitted by S. ... Two third-stage larvae that could not be differentiated from O. volvulus were found once in S. gonzalezi; however, transmission ... Abstract A comprehensive study of the transmission of Onchocerca volvulus at 4 locations in Guatemala with different prevalence ... Transmission of Onchocerca Volvulus by Secondary Vectors in Guatemala * Authors: Charles H. Porter, Richard C. Collins ...
Antigenic Mimicry: Onchocerca volvulus Antigen-Specific T Cells and Ocular Inflammation Nicol M. McKechnie; Werner Gürr; ... The Onchocerca volvulus antigen Ov39 is cross-reactive with the retinal antigen hr44 and induces ocular inflammation in rats ... Antigenic Mimicry: Onchocerca volvulus Antigen-Specific T Cells and Ocular Inflammation You will receive an email whenever this ... McKechnie NM, Gürr W, Braun G. Immunization with the cross-reactive antigens Ov39 from Onchocerca volvulus and hr44 from human ...
A novel type of glutathione S-transferase in Onchocerca volvulus.. E Liebau, G Wildenburg, R D Walter, K Henkle-Dührsen ... A novel type of glutathione S-transferase in Onchocerca volvulus. Message Subject (Your Name) has forwarded a page to you from ... Onchocerca volvulus is a pathogenic human filarial parasite which, like other helminth parasites, is capable of evading the ... volvulus appears to possess the characteristics of a secreted enzyme. When the complete O. volvulus GST1 (OvGST1) sequence ...
Doxycycline treatment to eliminate Onchocerca volvulus worms that respond poorly to ivermectin: a double-blind randomised ... Doxycycline treatment to eliminate Onchocerca volvulus worms that respond poorly to ivermectin ... Proportion of sterile or dead female O. volvulus worms in nodules from doxycycline-treated onchocerciasis patients, measured 20 ...
Evolution of Onchocerca volvulus microfilarial density (mf/mg) between 80 and 180 days after ivermectin treatment.Microfilarial ... Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply ... Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply ... pntd-0002084-g003: Evolution of Onchocerca volvulus microfilarial density (mf/mg) between 80 and 180 days after ivermectin ...
Analysis of Onchocerca volvulus à ²-tubulin gene polymorphism in the Mbonge sub-division of Cameroon: Evidence of gene ... Analysis of Onchocerca volvulus à ²-tubulin gene polymorphism in the Mbonge sub-division of Cameroon: Evidence of gene ... Analysis of Onchocerca volvulus ?-tubulin gene polymorphism in the Mbonge sub-division of Cameroon: Evidence of gene selection ... One gene shown to be linked to IVM selection in Onchocerca volvulus and also known to be associated with IVM resistance in ...
Efficacy of ivermectin against Onchocerca volvulus in Ghana. / Burnham, Gilbert M.. In: The Lancet, Vol. 370, No. 9593, 29.09. ... Burnham, GM 2007, Efficacy of ivermectin against Onchocerca volvulus in Ghana, The Lancet, vol. 370, no. 9593, pp. 1125. ... Efficacy of ivermectin against Onchocerca volvulus in Ghana. In: The Lancet. 2007 ; Vol. 370, No. 9593. pp. 1125. ... Burnham, G. M. (2007). Efficacy of ivermectin against Onchocerca volvulus in Ghana. The Lancet, 370(9593), 1125. https://doi. ...
R Lucius, N Erondu, A Kern, J E Donelson; Molecular cloning of an immunodominant antigen of Onchocerca volvulus.. J Exp Med 1 ... Molecular cloning of an immunodominant antigen of Onchocerca volvulus. R Lucius R Lucius ... Immunological crossreactivity between a cloned antigen of Onchocerca volvulus and a component of the retinal pigment epithelium ... Characterization of an immunodominant Onchocerca volvulus antigen with patient sera and a monoclonal antibody. ...
Novel cuticular collagen Ovcol-1 of Onchocerca volvulus is preferentially recognized by immunoglobulin G3 from putatively ... Novel cuticular collagen Ovcol-1 of Onchocerca volvulus is preferentially recognized by immunoglobulin G3 from putatively ...
Characterization of an immunodominant Onchocerca volvulus antigen with patient sera and a monoclonal antibody. R Lucius R ... Immunological crossreactivity between a cloned antigen of Onchocerca volvulus and a component of the retinal pigment epithelium ... Characterization of an immunodominant Onchocerca volvulus antigen with patient sera and a monoclonal antibody.. J Exp Med 1 ... Adult Onchocerca voluvlus and infective larvae, but not microfilariae contain an immunodominant antigen (33,000 and 21,000 Mr ...
Onchocerca volvulus is endemic in 30 countries in tropical Africa (from the Atlantic coast to the Red Sea) and southern Arabia ... Female Onchocerca produce microfilariae that live in the tissue within the nodules or skin. Starting from the site of the ... The adult Onchocerca live in the connective and fatty tissues, usually tightly coiled in connective tissue nodules in the ... Humans are the sole parasite reservoir of O. volvulus. Onch-ocercosis occurs in endemic foci along the rivers in which the ...
Onchocerca volvulus which causes a disease, Onchocerciasis, some of which when left untreated can develop visual defect ( ... VGKC antibodies and serum leiomidin-1 antibody cross reacting with Onchocerca Volvulus (OV). These findings suggest a neuro- ... the unique explanation for the association between Nodding Syndrome and Onchocerca Volvulus. Many clinical and epidemiological ... Nodding syndrome (NS) and Onchocerca Volvulus (OV) in Northern Uganda. David Kitara Lagoro, Denis Anywar Arony The Pan African ...
Onchocerca volvulus can be found mainly in West Africa, and also in Central and South America. Most likely, this species was ... Adults of Onchocerca volvulus are long and slender, have a smooth cuticle, and have blunt anterior and posterior ends. There ... Onchocerca volvulus has a complex life cycle involving a definitive and intermediate host. The only natural definitive host is ... Onchocerca volvulus has a complex life cycle involving a definitive and intermediate host. The only natural definitive host is ...
... 164 ???????. 2013 ???.. LAP Lambert Academic Publishing. ... To avoid this set back a direct study on O. volvulus may provide direct biological information on O. volvulus. Six biologically ... O. volvulus is a worm that causes Onchocerciasis which has blindness as its main pathology. The worm shares a few ... Individuals co-infected with L. loa and O. volvulus also experience adverse reactions with ivermectin. An ideal drug should ...
Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead ... The genome of Onchocerca volvulus, agent of river blindness James A Cotton 1 , Sasisekhar Bennuru 2 , Alexandra Grote 3 , ... The genome of Onchocerca volvulus, agent of river blindness James A Cotton et al. Nat Microbiol. 2016. . ... Onchocerca volvulus, Wolbachia and river blindness. Pearlman E, Gillette-Ferguson I. Pearlman E, et al. Chem Immunol Allergy. ...
... Academic Article ... Disease infectivity initiates from the filarial parasitic nematode Onchocerca volvulus, which is transmitted by the blackfly ... Our results demonstrate that NATOG tracks O. volvulus metabolism in both worms and humans, and thus can be considered a host- ... volvulus. The regulation of this tyramine neurotransmitter was found to be linked to patient disease infection, including the ...
Jabar Etaby 1 2 Onchocerca volvulus (Blinding filariasis; river blindness) Microfilaria of Onchocerca volvulus, from skin snip ... Onchocerca-Simulium complexes 1 - transmission of forest and Sudan-savanna strains of Onchocerca volvulus from Cameroon, by ... Effect of single-dose invermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement British ... This paper describes the detailed ocular findings of 785 Onchocerca volvulus infected individuals living in a hyperendemic area ...
  • O. volvulus parasites obtain nutrients from the human host by ingesting blood or by diffusion through their cuticle . (wikipedia.org)
  • A 35 kDa fragment of the Ov-WolAspAT was expressed in Escherichia coli, and immunolocalization using polyclonal antibodies against this antigen revealed that Ov-WolAspAT is present in a considerable proportion of the Wolbachia from O. volvulus, as well as in the endobacteria of several other filarial parasites. (wustl.edu)
  • Western blot analysis using recombinant Ov-WolAspAT as antigen showed that IgG1 antibodies were present in 70 (51%) individuals living in areas endemic for O. volvulus, B. malayi or Wuchereria bancrofti and no IgG4 or IgE antibodies were found. (wustl.edu)
  • Digestion of O. volvulus homogenate with endoglycosidase, followed by detection of OvGST1 with specific antibody, indicated that the enzyme possesses at least two N-linked oligosaccharide chains. (asm.org)
  • These data showed that the combined use of rOVOC3261 with OV-16 improved case detection, a current and urgent need for the efforts to achieve the worldwide elimination of transmission of O. volvulus. (cdc.gov)