Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Blood Pressure Determination: Techniques for measuring blood pressure.Blood Pressure Monitoring, Ambulatory: Method in which repeated blood pressure readings are made while the patient undergoes normal daily activities. It allows quantitative analysis of the high blood pressure load over time, can help distinguish between types of HYPERTENSION, and can assess the effectiveness of antihypertensive therapy.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Hydrostatic Pressure: The pressure due to the weight of fluid.Systole: Period of contraction of the HEART, especially of the HEART VENTRICLES.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Blood Pressure Monitors: Devices for continuously measuring and displaying the arterial blood pressure.Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.Pulse: The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.Adrenergic beta-1 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Renin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Diastole: Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.Rats, Inbred SHR: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.Intraocular Pressure: The pressure of the fluids in the eye.Arterial Pressure: The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.Intracranial Pressure: Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.Sympathetic Nervous System: The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.Transducers, Pressure: Transducers that are activated by pressure changes, e.g., blood pressure.Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Bendroflumethiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Betaxolol: A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Baroreflex: A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.Cardiovascular System: The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Rats, Inbred WKY: A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Cardiac Output: The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Physical Exertion: Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.Venous Pressure: The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.Atmospheric Pressure: The pressure at any point in an atmosphere due solely to the weight of the atmospheric gases above the point concerned.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Air Pressure: The force per unit area that the air exerts on any surface in contact with it. Primarily used for articles pertaining to air pressure within a closed environment.Sphygmomanometers: Instruments for measuring arterial blood pressure consisting of an inflatable cuff, inflating bulb, and a gauge showing the blood pressure. (Stedman, 26th ed)Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Sodium Chloride, Dietary: Sodium chloride used in foods.Oxprenolol: A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Diet, Sodium-Restricted: A diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states. (Dorland, 27th ed)Heart: The hollow, muscular organ that maintains the circulation of the blood.Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.Sodium, Dietary: Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.Body Mass Index: An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Celiprolol: A cardioselective beta-1 adrenergic antagonist that has intrinsic symopathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.Ventricular Pressure: The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Acebutolol: A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Arteries: The vessels carrying blood away from the heart.Posture: The position or attitude of the body.Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.Pressoreceptors: Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.Nadolol: A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.Central Venous Pressure: The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.Receptors, Adrenergic, beta: One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.Perindopril: An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Methyldopa: An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.African Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Africa.Indapamide: A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Diuretics: Agents that promote the excretion of urine through their effects on kidney function.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Butoxamine: A beta-2 selective adrenergic antagonist. It is used primarily in animal and tissue experiments to characterize BETA-2 ANDRENERGIC RECEPTORS.Aorta: The main trunk of the systemic arteries.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Telemetry: Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Blood Glucose: Glucose in blood.Cardiovascular Physiological Phenomena: Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.Monitoring, Physiologic: The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Respiration: The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.Pulmonary Wedge Pressure: The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Adrenergic beta-Agonists: Drugs that selectively bind to and activate beta-adrenergic receptors.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Pregnancy Complications, Cardiovascular: The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Hypertension, Renovascular: Hypertension due to RENAL ARTERY OBSTRUCTION or compression.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Receptors, Adrenergic, beta-1: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.TetrazolesHypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Natriuresis: Sodium excretion by URINATION.Timolol: A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.Compliance: Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Sodium Chloride Symporter Inhibitors: Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.Renal Circulation: The circulation of the BLOOD through the vessels of the KIDNEY.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Prehypertension: Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Bisoprolol: A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Lisinopril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.Osmotic Pressure: The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Carotid Arteries: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Supine Position: The posture of an individual lying face up.Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. 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Having a high systolic blood pressure increases risk of heart disease and death in young adults, even when diastolic blood pressure is normal, according to a study published in the Journal of the American College of Cardiology.. Doctors typically use an inflatable arm cuff to measure blood pressure, which is recorded in millimeters of mercury (abbreviated as "mmHg") and has two numbers. The top number, called systolic blood pressure, measures pressure in the arteries when the heart beats. The bottom number, called diastolic blood pressure, refers to blood pressure when the heart is at rest. When patients have a blood pressure above normal (120/80 mmHg), they are considered to have prehypertension or hypertension. However, its possible to have a high systolic ...
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TY - JOUR. T1 - Systolic blood pressure responses to enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) and hydrochlorothiazide in conscious Dahl salt-sensitive and salt-resistant rats. AU - Sharma, J. N.. AU - Fernandez, P. G.. AU - Kim, B. K.. AU - Triggle, Christopher. PY - 1984. Y1 - 1984. N2 - Systolic blood pressure responses to enalapril maleate (MK 421, a new angiotensin converting enzyme inhibitor (CEI) and hydrochlorothiazide (HTZ) were studied in conscious Dahl salt-sensitive (DS) and salt-resistant (DR) rats maintained on a high salt (8.0% NaCl) and a normal salt (0.4% NaCl) diet. The DS rats were severely hypertensive after 3 weeks on the high salt diet whereas the systolic blood pressure (SBP) of the DR rats were normotensive. Oral treatment with enalapril (15-100 mg.kg-1.day-1) and HTZ (60-400 mg.kg-1.day-1) caused a significant reduction of SBP in the DS rats with the high ...
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The antihypertensive effect of atenolol, with and without chlorthalidone, on hypertension was assessed in an outpatient as well as in an inpatient study. In the outpatient study atenolol alone induced decreases in systolic and diastolic BP amounting to 20 and 15 mm Hg. Maximal response of BP and HR developed within a week at the lowest dose used (100 mg twice daily). Combined atenolol-chlorthalidone treatment decreased lying and standing systolic BP by 7 and 14 mm Hg more than atenolol alone, but diastolic BP was decreased little more. In the inpatient study the addition of atenolol to chlorthalidone therapy in a dose of 100 mg twice daily resulted in a maximal decrease in BP within 3 days. At this dose PRA was lowered only slightly. Larger doses did not lead to any significant further decrease in BP, whereas PRA fell progressively. Our results indicate that, in contrast to nonselective blockade, specific beta-1-adrenoceptor ...
Treatment of High blood pressure is abnormally high blood pressure with no known cause. Blood pressure measurements are read as two numbers. The higher number is called the systolic pressure. The lower number is called the diastolic pressure. Normal systolic pressure is 120 or less, and normal diastolic blood pressure is 80 or less, High blood pressure is defined as systolic pressure greater than 140 and/or diastolic pressure greater than 90. People with systolic blood pressures between 120 and 139, or diastolic pressures of 80 to 89 are considered pre-hypertensive and need medical monitoring and lifestyle changes, High blood pressure puts stress on the heart, lungs, brain, ...
Objective(s) Our aim was to calculate the predictability of different blood pressure measures for cardiovascular mortality in a cohort of both men and women. We also aimed to determine whether clinically applicable cut-off levels for cardiovascular mortality risk of these measures work well. Materials and methods A healthcare need investigation from the 1970s was used. Participants aged 46-65 were included, n=788 (390 men and 398 women). The following blood pressure measures were studied: systolic, diastolic, mean, mid, and pulse pressure. The participants were followed for 26 years with respect to cardiovascular mortality through the Swedish Cause-of-Death Register. Isolated diastolic hypertension failed to show significant associations with cardiovascular mortality. Results Combined systolic and diastolic hypertension showed twice as high cardiovascular mortality in men and women compared with those with normal ...
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Source: American Journal of Therapeutics. 1997 April; 4(4): 117-22. cmd=Retrieve&db=PubMed&list_ uids=10423600&dopt=Abstract • Quality of life before and during antihypertensive treatment: a comparative study of celiprolol and atenolol. Author(s): Cleophas TJ, van der Mey N, van der Meulen J, Niemeyer MG. Source: Int J Clin Pharmacol Ther. 1996 July; 34(7): 312-7. cmd=Retrieve&db=PubMed&list_ uids=8832309&dopt=Abstract • Quality of life in hypertensives treated with atenolol or captopril: a double-blind crossover trial. Source: Cardiology. 2001; 96(2): 65-71. cmd=Retrieve&db=PubMed&list_ uids=11740134&dopt=Abstract • Different effects of fosinopril and atenolol on wave reflections in hypertensive patients. Author(s): Chen CH, Ting CT, Lin SJ, Hsu TL, Yin FC, Siu CO, Chou P, Wang SP, Chang MS. Source: Hypertension. 1995 May; 25(5): 1034-41. cmd=Retrieve&db=PubMed&list_ uids=7737712&dopt=Abstract Studies 25 • Different hemodynamic effects of celipropol and ...
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KP Hanretty, MJ Whittle, PC Rubin; Influence of Atenolol on Human Umbilical and Uteroplacental Doppler Flow Velocity Waveforms. Clin Sci (Lond) 1 January 1988; 74 (s18): 64P. doi: https://doi.org/10.1042/cs074064Pa. Download citation file:. ...
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Atenolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Atenolol and chlorthalidone is a combination medicine used to...
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Angiotensin II receptor blockade reduces new-onset atrial fibrillation and subsequent stroke compared to atenolol: The Losartan Intervention for End point reduction in hypertension (LIFE) study Academic Article ...
OBJECTIVE: To obtain further insight into the mechanism underlying the vasodilator effect of nebivolol. Since oxidative inactivation of nitric oxide (NO) is regarded as an important cause of its decreased biological activity, we studied (1) the effect of nebivolol on some oxidative parameters in essential hypertensive patients; (2) the effect of plasma of nebivolol-treated patients on reactive oxygen species production and NO availability in endothelial cells. METHODS: A total of 20 healthy subjects and 20 matched essential hypertensive patients treated with atenolol or nebivolol according to a double-blind, randomized design participated in the study. We measured low-density lipoprotein (LDL) and plasma hydroperoxides, 8-isoprostanes, oxidized LDL, susceptibility of LDL to oxidation (lag phase) and LDL vitamin E and the effect of plasma of nebivolol- and atenolol-treated patients on reactive oxygen species production and NO availability in endothelial cells exposed to ...
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The proposed work should help move toward the long-term goal of selection of antihypertensive drug therapy based on a patients genetic make-up. Hypertension (HTN) is the most common chronic disease for which drugs are prescribed, and the most prevalent risk factor for heart attack, stroke, renal failure and heart failure. Responses to antihypertensive drug therapy exhibit considerable interpatient variability, contributing to poor rates of HTN control (currently about 40-50% in the US), and frequent nonadherence and dropout from therapy. We propose to identify genetic predictors of the antihypertensive and adverse metabolic responses to two preferred and pharmacodynamically contrasting drugs, a beta-blocker (metoprolol) and a thiazide diuretic (chlorthalidone) in a sequential monotherapy design in 400 hypertensive individuals. Data collected will include home and clinic blood pressure, blood samples for testing for adverse metabolic effects and other ...
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The kinetic profiles of oral methimazole 40mg, propranolol 80mg, metoprolol 100mg and atenolol 100mg were compared in hyperthyroid patients both during the hyper-and euthyroid states. For...
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Reduction in the Risk of Stroke: The LIFE study was a multinational, double-blind study comparing losartan and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy. Patients with myocardial infarction or stroke within six months prior to randomization were excluded. Patients were randomized to receive once daily losartan 50 mg or atenolol 50 mg. If goal blood pressure (,140/90 mmHg) was not reached, hydrochlorothiazide (12.5 mg) was added first and, if needed, the dose of losartan or atenolol was then increased to 100 mg once daily. If necessary, other antihypertensive treatments (e.g., increase in dose of hydrochlorothiazide therapy to 25 mg or addition of other diuretic therapy, calcium channel blockers, alpha-blockers, or centrally acting agents, but not ACE inhibitors, angiotensin II antagonists, or beta-blockers) were added to the treatment regimen to reach the goal ...
OBJECTIVE: This study aims to establish the benefits of lowering cholesterol in diabetic patients with well-controlled hypertension and average/below-average cholesterol concentrations, but without established coronary disease. RESEARCH DESIGN AND METHODS: In the lipid-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA), 10,305 hypertensive patients with no history of coronary heart disease (CHD) but at least three cardiovascular risk factors were randomly assigned to receive 10 mg atorvastatin or placebo. Effects on total cardiovascular outcomes in 2,532 patients who had type 2 diabetes at randomization were compared. RESULTS: During a median follow-up of 3.3 years, concentrations of total and LDL cholesterol among diabetic participants included in ASCOT-LLA were approximately 1 mmol/l lower in those allocated atorvastatin compared with placebo. There were 116 (9.2%) major cardiovascular events or procedures in the atorvastatin group and 151 (11.9%) events in the placebo group
A randomized, placebo-controlled, double-blind crossover investigation in 12 patients with non-asthmatic chronic obstructive lung disease and co-existing stable angina pectoris was done to compare...
The LIFE study was a multinational, double-blind study comparing losartan potassium and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy. Patients with myocardial infarction or stroke within six months prior to randomization were excluded. Patients were randomized to receive once daily losartan potassium 50 mg or atenolol 50 mg. If goal blood pressure (,140/90 mmHg) was not reached, hydrochlorothiazide (12.5 mg) was added first and, if needed, the dose of losartan potassium or atenolol was then increased to 100 mg once daily. If necessary, other antihypertensive treatments (e.g., increase in dose of hydrochlorothiazide therapy to 25 mg or addition of other diuretic therapy, calcium-channel blockers, alpha-blockers, or centrally acting agents, but not ACE inhibitors, angiotensin II antagonists, or beta-blockers) were added to the treatment regimen to reach the goal blood ...
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Major findings from this double-blind, parallel-design, 1-year trial on a small group of previously untreated subjects with mild-to-moderate hypertension who accepted to have gluteal subcutaneous biopsies for sampling of resistance vessels demonstrate the following: (1) treatment with the selective mineralocorticoid antagonist eplerenone with good BP control reduced stiffness and the collagen/elastin ratio in resistance arteries; (2) resistance vessels from atenolol-treated patients exhibited increased stiffness and unchanged collagen/elastin ratio, despite similar effective BP control; and (3) there was improved inflammatory status in eplerenone-treated patients.. Hypertensive subjects in the present study demonstrated eutrophic small artery remodeling as expected in patients with newly diagnosed uncomplicated hypertension. We have reported previously that structural remodeling (increased media/lumen ratio) of resistance arteries occurs as an early stage in the progression of the ...
Background The Swedish irbesartan left ventricular hypertrophy investigation versus atenolol (SILVHIA). Objective Angiotensin II induces myocardial hypertrophy. We hypothesized that blockade of angiotensin II subtype 1 (AT1) receptors by the AT1-receptor antagonist irbesartan would reduce left ventricular mass (as measured by echocardiography) more than conventional treatment with a beta blocker. Design and methods This double-blind study randomized 115 hypertensive men and women with left ventricular hypertrophy to receive either irbesartan 150 mg q.d. or atenolol 50 mg q.d. for 48 weeks. If diastolic blood pressure remained above 90 mmHg, doses were doubled, and additional medications (hydrochlorothiazide and felodipine) were prescribed as needed. Echocardiography was performed at weeks 0, 12, 24 and 48. Results Baseline mean blood pressure was 162/104 mmHg, and mean left ventricular mass index was 157 ...
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Ahaneku G.I., Osuji C.U., Anisiuba B.C., Ikeh V.O., Oguejiofor O.C. and Ahaneku J.E., (2011). Evaluation of blood pressure and indices of obesity in a typical rural community in eastern Nigeria. Ann. Afr. Med. 10 (2): 120-6.. Allain C.C., Poon L.S., Chain C.S.G., Richmond W,. and Fu P.C., (1974). Enzymatic etermination of the serum cholesterol. Clin. Chem. 20(4): 470-475.. Barham D. and Trinder P., (1972). Clinical guide to laboratory test. Analyst 97: 142.. Barzilay J.I., Davis B.R., Cutler J.A., Pressel S.L., Whelton P.K., Basile J., Margolis KL., Ong S.T., Sadler L.S. and Summerson J., (2006). Fasting glucose levels and incident diabetes mellitus in older non-diabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT). Ach. Intern. Med. 166(20): 2191-2201.. Benson S.C., Pershadsingh H.A., Chittiboyina A., Desai P., Pravenec M., Qi N., Wang ...
In this issue of Circulation, Benjamin et al1 provide evidence from the Framingham cohort that atrial fibrillation (AF) increases the mortality rate and that this association persists when adjusted for age, hypertension, smoking, diabetes, electrocardiographic left ventricular hypertrophy, myocardial infarction, congestive heart failure, valvular heart disease, and stroke or transient ischemic attack. The current analysis showed that of the 5209 residents of Framingham who originally enrolled in this population study, 621 developed AF during follow-up. Participants who developed AF were more likely to have hypertension, a smoking habit, electrocardiographic left ventricular hypertrophy, myocardial infarction, congestive heart failure, valvular heart disease, and stroke or transient ischemic attack at baseline. Echocardiographic left atrial dimension was not available for analysis. The age-adjusted odds ratios for death with AF were 2.4 for men and 3.5 for women. After adjusting for risk factor ...
5 mg of hydrochlorothiazide, and is an oval shaped tablet. Hyzaar 100/25 contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide…. Losartan belongs to the class of medications called angiotensin II receptor blockers. In this way, fluid retention can be caused by absorbing high Order Zyprexa No Perscription quantity of the salt. 5 mg) once daily. Your doctor may ask you to Hyzaar (Losartan Hydrochlorothiazide) Buy O buy Hyzaar if you are at risk of stroke due to high blood pressure. It is yellow and has 717 on Buy Hyzaar (Losartan Hydrochlorothiazide) T one side, and is blank on the other side In a randomized, double-blind, comparative study (Losartan Intervention for Endpoint [LIFE] reduction in hypertension) of approximately 4 years duration in more than 9000 patients, losartan-based antihypertensive therapy (e. 5mg and 100/25mg and in different quantities Buy . 21 per pill or unit. 20. Buy Hyzaar From North Drug Store. For the treatment of hypertension. Buy ...
Oxprenolol (brand names Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure. Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water-soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation. Oxprenolol is a beta blocker. In addition, it has been found to act as an antagonist of the serotonin ...
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A high sensitivity reversed-phase HPLC method is presented for the simultaneous determination of marker compounds of paracellular transport (atenolol), transcellular transport (propranolol) and P-gp functionality (talinolol) in the Caco-2 system. The Caco-2 system is presently commonly accepted as an in vitro cell culture model of the intestinal mucosa. A programmed wavelength fluorescence detection method was used to optimise the response of the marker compounds. This marker compound mixture and the corresponding HPLC assay can be used for in house validation of the Caco-2 system or to evaluate simultaneously the effect of test compounds or absorption enhancing strategies on monolayer integrity and P-gp functionality. The method can easily be adapted to determine the concentration of atenolol, propranolol and talinolol in blood, thus allowing to use the same compounds in the in situ rat perfusion system with blood sampling from the ...
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Signal transduction by the insulin receptor is This loss of the ligand-receptor complex attenuates any further insulin-driven receptor liver and muscle by Pancreatic cancer is one of the most lethal human cancer and appropriate experimental tumor models are needed for the development of innovative therapeutic appr Lancet 373: 1773-1779. Diabetes Travel Packs Mid Challans Dr America sick day vacation you can how-many? Type 1 Diabetes Mellitus Treatment Patients with type 1 diabetes mellitus Analysis of data from the Juvenile Diabetes Research Foundation It is very common for individuals with type 2 diabetes to suffer from frequent episodes of urinary tract infections (UTI). Management of Type 2 Diabetes Mellitus.. Hot Pimento Cheese Dip is a delicious twist on the classic pimento cheese recipe taking it to dip form. This is what sets the stage for a variety of diabetic complications. Atenolol Diabetes Diabetes Drugs Other Than Insulin Atenolol Diabetes ::The 3 Step Trick that ...
Background. Migraine is a prevalent neurological disorder. Although prevention is the core of treatment for most, some patients are refractory to standard therapies. Accordingly, the aim of this study was to evaluate the use of Quetiapine (QTP) in the preventive treatment of refractory migraine, defined as previous unresponsiveness to the combination of atenolol, nortriptyline, and flunarizine. Methods. Thirty-four consecutive patients (30 women and 4 men) with migraine (ICHD-II), fewer than 15 days of headache per month, and not overusing symptomatic medications were studied. All participants had failed to the combination of atenolol (60 mg/day), nortriptyline (25 mg/day), and flunarizine (3 mg/day). Failure was defined as,50% reduction in attack frequency after 10 weeks of treatment. After other medications were discontinued, QTP was initiated at a single daily dose of 25 mg, and then titrated to 75 mg. After 10 weeks, headache frequency, consumption of rescue medications, ...
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Migraine is a common episodic headache disorder characterized by attacks that consist of various combinations of headache and neurologie, gastrointestinal, and autonomie symptoms. It has a one-year prevalence of approximately 18% in women, 6% in men, and 4% in children. The second edition of the International Classification of Headache Disorders (ICHD-2) subclassifies migraine into migraine… Read More ». ...
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5. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension and of the European Society of Cardiology. (PDF) 2007 Guidelines for the management of arterial hypertension. Eur Heart J 2007; 28: 1462-1536. 6. Agabiti Rosei E, Rizzoni D. Metabolic profile of nebivolol, a beta-adrenoceptor antagonist with unique characteristics. Drugs 2007; 67: 1091-1107. 7. Giugliano D, Acampora R, Marfella R, de Rosa N, Ziccardi P, Ragone R, de Angelis L, dOnofrio F. Metabolic and cardiovascular effects of carvedilol and atenolol in non-insulin-dependent diabetes mellitus and hypertension - a randomized, controlled trial. Ann Intern Med 1997; 126: 955-959. 8. Brixius K, Bundkirchen, Bolck B et al. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Br J Pharmacol 2001; 133: 1330-1338. 9. Maack C, Tyroller S, Schnabel P, Cremers B, Dabew E, Südkamp M, Böhm M. Characterization of beta-selectivity, ...
This analysis demonstrates that trial results of beta-blocker therapy in patients with CHF are consistent with a beneficial effect on total and cardiovascular mortality. The overall decrease in the odds of death was 31%, with one death prevented per 35 patients treated. The benefit from beta-blockade was consistent over the studies examined; however, it was most pronounced in the studies of carvedilol, which account for 55% of all included patients.. Previous studies, including a meta-analysis ([21]), have demonstrated that beta-blockade can improve left ventricular ejection fraction, symptoms and morbidity indices ([14-20]). The finding of improved mortality with beta-blockade has also been suggested by many previous studies, but most have lacked the statistical power to find even moderate improvements in survival ([14, 15, 17, 18, 33, 38, 42-44, 49, 56]). The results from this meta-analysis increase confidence in the hypothesis that beta-blockade reduces mortality in heart failure.. Previous ...
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We read with interest the article by Rimoldi et al [1] describing the increase in central aortic blood pressure (CBP) with ivabradine. The study is significant as it extends observations of attenuated reduction in CBP with beta-blockers compared with peripheral pressure [2] and shows increase in CBP with reduction of heart rate (HR) following 6 months ivabradine treatment. We wish to reconsider some of the findings and concepts in this study in the context that (i) HR values reported in patients treated with ivabradine in the study might benefit from further clarification and (ii) that the degree of relative increase in CBP observed with beta-blockers may potentially be more related to action of beta blockade than to intrinsic reduction of HR. Findings from the study by Rimoldi et al [1] are at variance with other studies investigating changes in central and peripheral pressure with ivabradine. In a recent double-blind, cross-over trial [3], ...
Vagaonescu T, Hussain A, Mehra A, Wilson AC, Moreyra AE. ST Segment Elevation Aute Myocardial Infarction Diagnosed By The Emergency Room: How Often Are They True? Cath and Cardiovasc Interv 2009, 74:159. Vagaonescu T, Moreyra AE, Wilson AC, Cosgrove NM, Kostis JB. Transfusions After Percutaneous Coronary Intervention For ST-T Segment Elevation Acute Myocardial Infarction Patients Are Associated With Increased Long Term Mortality: A Statewide Registry Study. Cath and Cardiovasc Interv 2009, 74:160. Vagaonescu T, Wilson AC, Kostis JB. Electrocardiographic Left Ventricular Hypertrophy Predicts Long Term Fatal Outcomes in Elderly Hypertensives Despite Diuretic-Based Antihypertensive Treatment: 14-Year Follow-Up of the systolic Hypertension in the Elderly Program (SHEP). Circulation Suppl. 2008. Yingzi Deng, William J Kostis, Alan Wilson, Nora Cosgrove, Yu-Hsuan Shao, Abel Moreyra, John B Kostis. The Impact of Atrial Fibrillation on the outcomes of patients suffering a second Myocardial Infarction: ...
5-25 mg daily) reduced the risk of the primary outcome of combined Price: $0. Hyzaar 100/25 contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide, and …. Hydrochlorothiazide is a first line diuretic drug of the thiazide class that acts by by blocking salt and fluid reabsorption in the kidneys. 5 mg) guide: What is Generic Hyzaar (Losartan with Hydrochlorothiazide)? If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high Common side effects of Losartan HCT include dizziness, lightheadedness, nausea, vomiting, dry cough, headache, increased sensitivity to sunlight, and diarrhea. Ilpersonale. When you buy Hyzaar taking extra fluids is recommended In a randomized, double-blind, comparative study (Losartan Intervention for Endpoint [LIFE] reduction in ...
The studies in this thesis describe the development of a microarray based minisequencing system and its application to highly parallel genotyping of single nucleotide polymorphisms. The technical developments included identification of a three-dimensional microarray surface coating with high binding capacity for oligonucleotides modified with amino groups as the most optimal one for the system. The system was also established for multiplexed, reproducible quantitative analysis of SNP alleles both on the level of DNA and RNA. The sensitivity of the system to distinguish SNP alleles present as a minority in a mixed sample was found to be 1-6%.. The microarray based minisequencing system was applied in a pharmacogenetic study on antihypertensive drug response. A panel of 74 SNPs located in candidate genes related to blood pressure regulation were genotyped in DNA samples from hypertensive patients that had been treated with the antihypertensive drugs irbesartan or ...
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ABSTRACT. In India. Fixed Dose Combinations(FDCs) have drawn the attention of health service providers and the service recipients. Therefore, the development of fixed dose combinations (FDCs) is becoming increasingly important from a public health perspective. The objective was to study the prescribing pattern and to assess the rationality of fixed dose combinations using seven point criteria. During the study period a total of 100 patients were enrolled based on inclusion and exclusion criteria. The study population includes an overall 56% male with an average age of 46.15 ± 19.33 years. A total of 538 drugs were prescribed to the patient with a mean of 5.38±5.77.The major therapeutic category of drugs prescribed were antibiotics (30.03%), antihypertensives (12.63%) and others (13.01%).The study population had 130 FDCs in which again antibiotics topped the list, followed by Anti-diabetics. Among these 92 contributed to antibiotic FDCs belonging to 15 different groups. The average interaction ...
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High blood pressure is a condition that normally affects adults, but can affect young children and adolescents, as well. High blood pressure in children is most commonly caused by unhealthy lifestyle or family history, but it can also be due to disease, such as kidney or heart disease. When a person has high blood pressure, the heart must work harder to pump blood throughout the body. If left untreated, high blood pressure can eventually cause damage to the heart, kidneys, and eyes. Recent studies have linked high blood pressure in children to deficits in brain functioning. However, more information is needed to confirm this connection and to determine the effectiveness of antihypertensive treatments in restoring brain function. This study will determine the effect of high blood pressure on ...
The principal findings of our study in hypertensive patients with stable CAD are that after a follow-up of 6 months, HR lowering with ivabradine was associated with an increase of 11 mm Hg in directly measured central systolic pressure. Further, there was an inverse correlation between the decrease in HR and the increase in central systolic pressure, indicating that the greater the negative chronotropic effect of ivabradine, the greater was the increase in central pressure. Moreover, the HR-lowering effect of ivabradine was associated with an increase in stroke volume without significant changes in cardiac output. Conceivably, the observed increase in central pressure could be because of a ventricular-vascular mismatch or of an increase in stroke volume.17 Under physiological conditions, when there is ventricular-vascular coupling, the reflected pulse wave returns to the left ventricle in diastole and serves to increase coronary perfusion. ...
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Of the patients enrolled in this study, ≈70% (5356 patients) were women, more than any previous study of statins and prevention. The results of the present analysis are based on detailed analyses of the women in the MEGA study. In the women in the MEGA study, the incidence of events was lower for women than for men, and the risk for women tended to rise with age, similar to the findings in previous reports.1-3 The generally low incidence of events in women requires a large sample size to make a valid comparison, which may have contributed to the lack of studies of women to date. The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS),11 Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial-Lipid Lowering Trial (ALLHAT-LLT),14 Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA),15 and Heart Protection Study (HPS)16 studied primary prevention, and Scandinavian Simvastatin Survival Study (4S),8 Long-Term Intervention With ...
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Solid-liquid partitioning is one of the main fate processes determining the removal of micropollutants in wastewater. Little is known on the sorption of micropollutants in biofilms, where molecular diffusion may significantly influence partitioning kinetics. In this study, the diffusion and the sorption of 23 micropollutants were investigated in novel moving bed biofilm reactor (MBBR) carriers with controlled biofilm thickness (50, 200 and 500 μm) using targeted batch experiments (initial concentration = 1 μg L−1, for X-ray contrast media 15 μg L−1) and mathematical modelling. We assessed the influence of biofilm thickness and density on the dimensionless effective diffusivity coefficient f (equal to the biofilm-to-aqueous diffusivity ratio) and the distribution coefficient Kd,eq (L g−1). Sorption was significant only for eight positively charged micropollutants (atenolol, metoprolol, propranolol, citalopram, venlafaxine, erythromycin, clarithromycin and roxithromycin), revealing the ...
Objective: To develop a validated stability-indicating analytical method for simultaneous estimation of Atenolol (ATN) and Hydrochlorothiazide (HTZ) in pharmaceutical combined dosage form by HPTLC. Method: A high performance thin layer chromatographic (HPTLC) method has been developed for the separation of ATN and HTZ on plates precoated with aluminium back silica gel 60 F254. Different mobile phases were used on trial and error basis for separation of two drugs. The final mobile phase selected for analysis was n-butanol: ethyl acetate: methanol: tetrahydrofuran in the ratio (1:2:2:1 v/v). Both the drugs showed maximum absorbance at 250 nm which was selected as the detection wavelength throughout the experimental work. Developed method was validated as per ICH guidelines. Forced degradation of drugs was carried out under various stress conditions and HPTLC method was used for analysing the stability of drugs. Result: HPTLC method was successfully developed for separation of ATN and HTZ with ...
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  • The combination of Atenolol with alcohol may cause dizziness.Moderate your alcohol consumption to prevent this. (dokteronline.com)
  • It does help improve the heart's efficiency in delivering blood and relieves the symptoms of inadequate flow of blood - dizziness, weakness, and shortness of breath. (drugs.com)
  • Hi,thanks for query.In your case it is likely that there is obstruction some where which is not allowing the blood pressure to come down with medicines.In some cases some hormonal tumors can also lead to this.Please talk to your doctor and get proper investigation done inform of Renal Doppler study and ultrasound for kidneys done.Please visit cardiologist for this. (healthcaremagic.com)
  • My question is how do I distinguish between normal chest pains and palpitations, given my condition, and the kinds I need to be concerned about? (druginfonet.com)
  • I had noticed for some time that my pulse rate was 42-43 and when i went to my GP complaining of breathlessness and pressure in my chest area on exertion she did an ekg (ecg? (healthboards.com)
  • Some antihypertensive agents may improve resistance artery remodeling in hypertensive patients whereas other agents may not, for similar blood pressure reduction. (ahajournals.org)
  • We questioned whether the selective mineralocorticoid receptor blocker eplerenone improves resistance artery remodeling in hypertensive patients versus the β-blocker atenolol. (ahajournals.org)
  • Sixteen hypertensive patients were randomly assigned to double-blind daily treatment with eplerenone or atenolol. (ahajournals.org)
  • In conclusion, in hypertensive patients, blood pressure control for 1 year with atenolol was associated with increased wall stiffness of resistance arteries, whereas eplerenone treatment was associated with reduced stiffness, decreased collagen/elastin ratio, and a reduction in circulating inflammatory mediators. (ahajournals.org)
  • These data raise the possibility that eplerenone treatment of hypertensive patients when normalizing blood pressure could potentially be associated with better vascular protection and outcomes than the β-blocker atenolol, which remains to be demonstrated. (ahajournals.org)
  • Normalization of elevated blood pressure (BP) in hypertensive individuals is associated with reduced target-organ damage and incident cardiovascular morbidity and mortality. (ahajournals.org)
  • In the present study we tested the hypothesis that remodeling of resistance arteries from mild-to-moderate hypertensive patients could be improved by the selective mineralocorticoid receptor blocker eplerenone compared with the β-blocker atenolol at equal levels of BP control. (ahajournals.org)
  • Some 'old' posts contain some very helpful info on atenolol, weaning, and withdrawal problems---you might check some of zuzu8 and zip's posts as they seem quite knowledgeable about beta blocker withdrawal. (healthboards.com)
  • An overdose often causes very low blood pressure and heart rate, causing weakness, fatigue and asthma attacks. (dokteronline.com)
  • If your heart rate tends to be fast, the Atenolol will help to slow it down. (drugs.com)
  • One thing Atenolol cant do is convert your heart back into normal rhythm once atrial fibrillation starts-other drugs are used to do that. (drugs.com)
  • When this happens the blood doesnt circulate properly and the blood can actually begin to clot so when the atrium begins working, a clot can be introduced leading to heart failure or stroke both of which can be fatal. (drugs.com)
  • This is because, atenolol has been clinically proven to reduce the risk of DEATH to those who have suffered from a heart attack. (termlife2go.com)
  • Don't immediately think that you're no longer going to be able to qualify for a traditional term or whole life insurance policy, just understand that the insurance companies are probably going to have some more "detailed" questions about your heart attack before they will be willing to provide coverage. (termlife2go.com)
  • Along with labetalol, celiprolol and carvedilol, it is one of four beta blockers to cause dilation of blood vessels in addition to effects on the heart. (wikipedia.org)
  • Made many visits to my doctor, and was told these symptoms were not from the Atenolol, and to keep taking it. (healthboards.com)
  • The beta-blocker group of drugs (of which atenolol is one) can occasionally do this - though admittedly atenolol itself is not well known for causing erection problems. (netdoctor.co.uk)
  • In order for drugs to be absorbed, they must pass through the epithelial cells that line the lumen wall before they can enter the hepatic portal circulation to be distributed systemically in blood circulation. (wikipedia.org)
  • There are some very, very helpful posts by people who have been on atenolol for years and were not given adequate instructions for weaning. (healthboards.com)
  • various doses for 8 years, now I developed AFIB, my Dr says just keep on Atenolol. (drugs.com)
  • I asked to to taken off Atenolol as I couldn't handle the side effects. (healthboards.com)
  • I've read lots of posts on this board about side effects from Atenolol, many of which I recognise, so would like to change to something else. (healthboards.com)
  • The brace transmits the weight from thigh to leg without putting much pressure on the injured knee (thus termed protective weight bearing). (justanswer.com)
  • Ask-a-doc Web sites: If you've got a quick question, you can try to get an answer from sites that say they have various specialists on hand to give quick answers. (justanswer.com)
  • Tory Johnson, GMA Workplace Contributor, discusses work-from-home jobs, such as JustAnswer in which verified Experts answer people's questions. (justanswer.com)
  • Not only did you answer my questions, you even took it a step further with replying with more pertinent information I needed to know. (justanswer.com)
  • Thank you for a very easy to understand answer to my question! (drugs.com)
  • Please log in or register to answer this question. (questionbay.com)
  • If you use Atenolol you may feel dizzy the first couple of days.This often disappears after a while and you are able to participate in traffic without any problems. (dokteronline.com)