The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Elements of limited time intervals, contributing to particular results or situations.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
All deaths reported in a given population.
Postmortem examination of the body.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
An infant during the first month after birth.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A cell line derived from cultured tumor cells.
Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.
Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Established cell cultures that have the potential to propagate indefinitely.
Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.
The killing of one person by another.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The act of killing oneself.
Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Maternal deaths resulting from complications of pregnancy and childbirth in a given population.
Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.
Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Used for general articles concerning statistics of births, deaths, marriages, etc.
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The confinement of a patient in a hospital.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Medical and nursing care of patients in the terminal stage of an illness.
Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Deaths that occur before LIFE EXPECTANCY is reached within a given population.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Transport proteins that carry specific substances in the blood or across cell membranes.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
The process by which chemical compounds provide protection to cells against harmful agents.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Glycoproteins found on the membrane or surface of cells.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Disruption of structural continuity of the body as a result of the discharge of firearms.
A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.
A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
The return of a sign, symptom, or disease after a remission.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The application of pathology to questions of law.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The event that a FETUS is born dead or stillborn.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the LUNG.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Refers to animals in the period of time just after birth.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Research techniques that focus on study designs and data gathering methods in human and animal populations.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Tumors or cancer of the human BREAST.
An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)
Inhaling and exhaling the smoke of burning TOBACCO.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Disease having a short and relatively severe course.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Proteins prepared by recombinant DNA technology.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Number of deaths of children between one year of age to 12 years of age in a given population.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.
Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Avoidable mortality in Europe 1955-1994: a plea for prevention. (1/6129)

OBJECTIVE: To analyse trends of avoidable mortality in Europe, emphasising causes of death amenable to primary prevention through reduction of exposures, secondary prevention through early detection and treatment, and tertiary prevention through improved treatment and medical care. DESIGN: Descriptive study of mortality from avoidable causes for the years 1955 through 1994, for ages 5-64 at time of death. Using the World Health Organisation Mortality Database, five year death rates were standardised to the world population. SETTING: 21 countries of Europe in four regions (northern, central, and southern Europe, Nordic countries). PARTICIPANTS: All causes of deaths for men and women, aged 5-64, at time of death. MAIN RESULTS: Between 1955-59 and 1990-94, the reduction in mortality was somewhat greater for avoidable causes than for all causes: 45.8% v 45.1% (women) and 39.3% v 32.6% among men. Reductions in mortality were greater for causes amenable to improved medical care: 77.9% among women and 76.3% among men. The smallest reduction in mortality was seen in women for causes amenable to secondary prevention (11.0%), and in men for causes amendable to primary prevention including tobacco related conditions (16.6%). From a geographical point of view, there were slight differences in trends between European regions, but overall the patterns were similar. CONCLUSIONS: The greatest reduction of avoidable mortality in Europe from 1955-94 came from causes amenable to improved treatment and medical care for both sexes. Further reductions of avoidable mortality can be achieved through implementation of primary and secondary prevention activities, such as tobacco control, reduction of occupational exposures, and universal access to breast and cervical cancer screening programmes.  (+info)

Comparative total mortality in 25 years in Italian and Greek middle aged rural men. (2/6129)

STUDY OBJECTIVE: Mortality over 25 years has been low in the Italian and very low in the Greek cohorts of the Seven Countries Study; factors responsible for this particularity were studied in detail. PARTICIPANTS AND SETTINGS: 1712 Italian and 1215 Greek men, aged 40-59 years, cohorts of the Seven Countries Study, representing over 95% of the populations in designated rural areas. DESIGN: Entry (1960-61) data included age, systolic blood pressure (SBP), smoking habits, total serum cholesterol, body mass index (BMI), arm circumference, vital capacity (VC), and forced expiratory volume in 3/4 seconds (FEV); the same data were obtained 10 years later. Multivariate Cox analysis was performed with all causes death in 25 years as end point. MAIN RESULTS: Italian men had higher entry levels of SBP, arm circumference, BMI, and VC; Greek men had higher cholesterol levels, smoking habits, and FEV. Mortality of Italian men was higher throughout; at 25 years cumulative mortality was 48.3% and 35.3% respectively. Coronary heart disease and stroke mortality increased fivefold in Italy and 10-fold in Greece between years 10 and 25. The only risk factor with a significantly higher contribution to mortality in Italian men was cholesterol. However, differences in entry SBP (higher in Italy) and FEV (higher in Greece) accounted for, according to the Lee method, 75% of the differential mortality between the two populations. At 10 years increases in SBP, cholesterol, BMI, and decreases in smoking habits, VC, FEV, and arm circumference had occurred (deltas). SBP increased more and FEV and VC decreased more in Italy than in Greece. Deltas, fed stepwise in the original model for the prediction of 10 to 25 years mortality, were significant for SBP, smoking, arm circumference, and VC in Greece, and for SBP and VC in Italy. CONCLUSION: Higher mortality in Italian men is related to stronger positive effects of entry SBP and weaker negative (protective) effects of FEV; in addition 10 year increases in SBP are higher and 10 year decreases in FEV are larger in Italy. Unaccounted factors, however, related to, for example, differences in the diet, may also have contributed to the differential mortality of these two Mediterranean populations.  (+info)

Respiratory symptoms and long-term risk of death from cardiovascular disease, cancer and other causes in Swedish men. (3/6129)

BACKGROUND: Depressed respiratory function and respiratory symptoms are associated with impaired survival. The present study was undertaken to assess the relation between respiratory symptoms and mortality from cardiovascular causes, cancer and all causes in a large population of middle-aged men. METHODS: Prospective population study of 6442 men aged 51-59 at baseline, free of clinical angina pectoris and prior myocardial infarction. RESULTS: During 16 years there were 1804 deaths (786 from cardiovascular disease, 608 from cancer, 103 from pulmonary disease and 307 from any other cause). Men with effort-related breathlessness had increased risk of dying from all of the examined diseases. After adjustment for age, smoking habit and other risk factors, the relative risk (RR) associated with breathlessness of dying from coronary disease was 1.43 (95% CI : 1.16-1.77), from stroke 1.77 (95% CI: 1.07-2.93), from any cardiovascular disease 1.48 (95% CI : 1.24-1.76), cancer 1.36 (95% CI : 1.11-1.67) and from any cause 1.62 (95% CI: 1.44-1.81). An independent effect of breathlessness on cardiovascular death, cancer death and mortality from all causes was found in life-time non-smokers, and also if men with chest pain not considered to be angina were excluded. An independent effect was also found if all deaths during the first half of the follow-up were excluded. Men with cough and phlegm, without breathlessness, also had an elevated risk of dying from cardiovascular disease and cancer, but after adjustment for smoking and other risk factors this was no longer significant. However, a slightly elevated independent risk of dying from any cause was found (RR = 1.18 [95% CI: 1.02-1.36]). CONCLUSION: A positive response to a simple question about effort related breathlessness predicted subsequent mortality from several causes during a follow-up period of 16 years, independently of smoking and other risk factors.  (+info)

Water traffic accidents, drowning and alcohol in Finland, 1969-1995. (4/6129)

OBJECTIVE: To examine age- and sex-specific mortality rates and trends in water traffic accidents (WTA), and their association with alcohol, in Finland. MATERIALS AND METHODS: National mortality and population data from Finland, 1969-1995, are used to analyse rates and trends. The mortality rates are calculated on the basis of population, per 100000 inhabitants in each age group (<1, 1-4, 5-14, 15-24, 25-44, 45-64, > or = 65), and analysed by sex and age. The Poisson regression model and chi2 test for trend (EGRET and StatXact softwares) are used to analyse time trends. RESULTS: From 1969 through 1995 there were 3473 (2.7/100000/year; M:F= 20.4:1) WTA-related deaths among Finns of all ages. In 94.7% of the cases the cause of death was drowning. Alcohol intoxication was a contributing cause of death in 63.0% of the fatalities. During the study period the overall WTA mortality rates declined significantly (-4% per year; P < 0.001). This decline was observed in all age groups except > or = 65 year olds. The overall mortality rates in WTA associated with alcohol intoxication (1987-1995) also declined significantly (-6%; P = 0.01). CONCLUSIONS: In Finland, mortality rates in WTA are exceptionally high. Despite a marked decline in most age groups, the high mortality in WTA nevertheless remains a preventable cause of death. Preventive countermeasures targeted specifically to adult males, to the reduction of alcohol consumption in aquatic settings and to the use of personal safety devices should receive priority.  (+info)

A method for calculating age-weighted death proportions for comparison purposes. (5/6129)

OBJECTIVE: To introduce a method for calculating age-weighted death proportions (wDP) for comparison purposes. MATERIALS AND METHODS: A methodological study using secondary data from the municipality of Sao Paulo, Brazil (1980-1994) was carried out. First, deaths are weighted in terms of years of potential life lost before the age of 100 years. Then, in order to eliminate distortion of comparisons among proportions of years of potential life lost before the age of 100 years (pYPLL-100), the denominator is set to that of a standard age distribution of deaths for all causes. Conventional death proportions (DP), pYPLL-100, and wDP were calculated. RESULTS: Populations in which deaths from a particular cause occur at older ages exhibit lower wDP than those in which deaths occur at younger ages. The sum of all cause-specific wDP equals one only when the test population has exactly the same age distribution of deaths for all causes as that of the standard population. CONCLUSION: Age-weighted death proportions improve the information given by conventional DP, and are strongly recommended for comparison purposes.  (+info)

The meaning and use of the cumulative rate of potential life lost. (6/6129)

BACKGROUND: The 'years of potential life lost' (YPLL) is a public health measure in widespread use. However, the index does not apply to the comparisons between different populations or across different time periods. It also has the limit of being cross-sectional in nature, quantifying current burden but not future impact on society. METHODS: A new years-lost index is proposed-the 'cumulative rate of potential life lost' (CRPLL). It is a simple combination of the 'cumulative rate' (CR) and the YPLL. Vital statistics in Taiwan are used for demonstration and comparison of the new index with existing health-status measures. RESULTS: The CRPLL serves the purpose of between-group comparison. It can also be considered a projection of future impact, under the assumption that the age-specific mortality rates in the current year prevail. For a rare cause of death, it can be interpreted as the expected years (days) of potential life lost during a subject's lifetime. CONCLUSIONS: The CRPLL has several desirable properties, rendering it a promising alternative for quantifying health status.  (+info)

Toxic oil syndrome mortality: the first 13 years. (7/6129)

BACKGROUND: The toxic oil syndrome (TOS) epidemic that occurred in Spain in the spring of 1981 caused approximately 20000 cases of a new illness. Overall mortality and mortality by cause in this cohort through 1994 are described for the first time in this report. METHODS: We contacted, via mail or telephone, almost every living member of the cohort and family members of those who were known to have died in order to identify all deaths from 1 May 1981 through 31 December 1994. Cause of death data were collected from death certificates and underlying causes of death were coded using the International Classification of Diseases, 9th Revision. RESULTS: We identified 1663 deaths between 1 May 1981 and 31 December 1994 among 19 754 TOS cohort members, for a crude mortality rate of 8.4%. Mortality was highest during 1981, with a standardized mortality ratio (SMR) of 4.92 (95% confidence interval [CI]: 4.39-5.50) compared with the Spanish population as a whole. The highest SMR, (20.41, 95% CI: 15.97-25.71) was seen among women aged 20-39 years during the period from 1 May 1981 through 31 December 1982. Women <40 years old, who were affected by TOS , were at greater risk for death in most time periods than their unaffected peers, while older women and men were not. Over the follow-up period, mortality of the cohort was less than expected when compared with mortality of the general Spanish population, or with mortality of the population of the 14 provinces where the epidemic occurred. We also found that, except for deaths attributed to external causes including TOS and deaths due to pulmonary hypertension, all causes of death were decreased in TOS patients compared to the Spanish population. The most frequent underlying causes of death were TOS, 350 (21.1%); circulatory disorders, 536 (32.3%); and malignancies, 310 (18.7%). CONCLUSIONS: We conclude that while on average people affected by toxic oil syndrome are not at greater risk for death over the 13-year study period than any of the comparison groups, women <40 years old were at greater risk of death.  (+info)

Failing firefighters: a survey of causes of death and ill-health retirement in serving firefighters in Strathclyde, Scotland from 1985-94. (8/6129)

During the decade beginning 1 January 1985, 887 full-time firefighters, all male, left the service of Strathclyde Fire Brigade (SFB). There were 17 deaths--compared to 64.4 expected in the Scottish male population aged 15-54 years--giving a standardized mortality ratio (SMR) of 26, and 488 ill-health retirements (IHR). None of the deaths was attributable to service, the major causes being: myocardial infarction--five, (expected = 17.3; SMR = 29); cancers--three (colon, kidney and lung) (expected = 13.6; SMR = 22); road traffic accidents--two (expected = 4.17; SMR = 48) and suicide--two (expected = 4.9; SMR = 41). Amalgamating the deaths and IHRs showed that the six most common reasons for IHR were musculoskeletal (n = 202, 40%), ocular (n = 61, 12.1%), 'others' (n = 58, 11.5%), injuries (n = 50, 9.9%), heart disease (n = 48, 9.5%) and mental disorders (n = 45, 8.9%). Over 300 IHRs (over 60%) occurred after 20 or more years service. When the IHRs were subdivided into two quinquennia, there were 203 and 302 in each period. Mean length of service during each quinquennium was 19.4 vs. 21.3 years (p = 0.003) and median length was 21 years in both periods; interquartile range was 12-26 years in the first and 17-27 years in the second period (p = 0.002), but when further broken down into diagnostic categories, the differences were not statistically significant, with the exception of means of IHRs attributed to mental disorders (14.5 vs. 19 years, p = 0.03).  (+info)

This study had 4 main findings. First, age-standardized mortality from group 1, 2 and 3 causes decreased rapidly after 1988, 1995 and 1994, respectively. Second, cardio-cerebrovascular disease-, cancer-, and diabetes-related deaths clearly increased in those born around the time of the Great Chinese Famine. Third, the risks of the major group 2 cause-related deaths peaked in those born between 1911 and 1928, and then declined, but the risks of death from cancer and diabetes began to increase in those born after 1949. Fourth, cardio-cerebrovascular disease and cancer remain the top 2 killers. Diabetes will likely be the third most common cause of death in women and the fourth most common cause of death in men.. The trends in age-standardized mortality reflect the effect of public health efforts and the nature of life-threatening diseases. Deaths from group 1 causes decreased after 1988, corresponding to the actions taken by the municipal government to greatly enhance public health infrastructure ...
This dictionary covers most common death causes during the end of 18th and first half of 19th century. As the medical knowledge improved there are more and more causes in the registries and its almost impossible to cover all of them. The death causes here are those you will most probably see in the death registries. For example - death registry of Nový Přerov shows only 26 different death causes between 1784 and 1810 ...
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. The effect of socioeconomic factors on cause-specific mortality and burden of CVD is rarely evaluated in low- and middle-income countries, especially in a rapidly changing society. Original data were derived from the vital registration system in Yangpu, a representative, population-stable district of urban Shanghai, China, during 1974-2015. Temporal trends for the mortality rates and burden of CVD during 1974-2015 were evaluated using Joinpoint Regression Software. The burden was evaluated using age-standardized person years of life loss per 100,000 persons (SPYLLs). Age-sex-specific CVD mortality rates were predicted by using age-period-cohort Poisson regression model. A total of 101,822 CVD death occurred during 1974-2015, accounting for 36.95% of total death. Hemorrhagic stroke, ischemic heart disease, and ischemic stroke were the 3 leading causes of CVD death. The age-standardized CVD mortality decreased from 144.5/100,000 to
The impact of long-term exposure to nitrogen dioxide (NO2) on cause-specific mortality is poorly understood.To assess mortality risks associated with long-term NO2 exposure and evaluate confounding of this association.We examined the association between 12-month moving average NO2 exposure and cause-specific mortality in 14.1 million US Medicare beneficiaries between 2000 and 2008. Associations were examined using age, gender, and race-stratified and state-adjusted Poisson regression models. We assessed the potential for confounding by PM2.5 and behavioral covariates and unmeasured confounding by decomposing NO2 into its spatial and spatio-temporal components.We found significant associations between 12-month NO2 exposure and increased mortality from all-causes [risk ratio (RR): 1.052; 95% CI: 1.051, 1.054; per 10 ppb], cardiovascular (CVD) (1.133; 95% CI: 1.130, 1.137) and respiratory disease (1.050; 95% CI: 1.044, 1.056), all cancers (1.021; 95% CI: 1.017, 1.025), ischemic heart disease (IHD) ...
Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: Data from the Chinese Longitudinal Healthy Longevity Survey ...
Suggested Citation: Garko, M.G. (2013, October). Fiber - Part IV: Dietary and functional fiber and the immediate cause of the obesity epidemic. Health and Wellness Monthly. Retrieved (insert month, day, year), from www.letstalknutrition.com. Fiber - Part IV: Dietary and Functional Fiber and the Immediate Cause of the Obesity Epidemic Michael Garko, Ph.D. Producer […]
External injuries, trauma and avoidable deaths in Agincourt, South Africa: a retrospective observational and qualitative study ...
Clinical trials commonly use adjudication committees to refine endpoints, but observational research or genome-wide association studies rarely do. Our goals were to establish definitions of cause-specific death after unrelated donor allogeneic hematopoietic cell transplantation (URD-HCT), estimate discordance between reported and adjudicated cause-specific death, and identify factors contributing to inconsistency in cause-specific deathdetermination. A consensus panel adjudicated cause-specific deathin 1,484 patients who died within 1 year after HCT, derived from 3,532 acute leukemia or myelodysplasia patients after URD-HCT 2000-2011 reported by 151 U.S. transplant centers to CIBMTR. Deaths were classified as disease-related (DRM) or transplant-related (TRM). The panel agreed with ,99% of deaths reported by centers as DRM and 80% reported as TRM. Year of transplant (cohort effect) and disease status significantly influenced agreement between panel and centers. Sensitivity analysis of deaths ,100 ...
The findings from our study are in agreement with a number of previous studies, showing increased risks of all cause and cardiovascular disease mortality in a cohort of patients discharged from hospital with diabetes. Because of the large size of the cohort, we were also able to explore cause specific mortality, which was found to be raised in comparison with the general population for most causes of death. Importantly, we found that the pattern of excess mortality, although broadly similar across ethnic groups, was substantially higher in Māori and lower in Pacific people compared with non-Māori/non-Pacific people for cardiovascular disease, the single greatest contributor to the excess mortality in patients with diabetes.. The study was based only a cohort of diabetes patients who were hospitalised, thus including those patients with more severe disease than a community based sample.. This raises the potential for reverse causality, as we are unable to determine either the temporality of the ...
Potential Years of Life Lost (PYLL) is given for each year from 1980 to 2012. Three separate PYLL indicators are included: PYLL65 up to age 65, PYLL70 up to age 70 and PYLL70_rate, which is the number of potential years of life lost up to age 70 per 100,000 population aged under 70. For the purposes of the last of these indicators, the WHO European Standard Population (see Appendix) has been used. For 2009 and 2010, year of registration data are used; for all previous years, statistics are based on year of occurrence. A total of 74 causes of death categories are reported. These are ordered according to the Eurostat 65 Cause of Death shortlist, along with 9 additional national categories. The classification system used for data up to and including 2006 is ICD9. From 2007, ICD10 is used. Caution should be exercised in comparing data up to 2006 with data from 2007 onwards. ...
There are many hidden bedwetting medical causes that a parents of a bedwetter should be aware of. Read these medical causes to learn more about bedwetting causes.
OBJECTIVES: Most analyses of asthma mortality in the United States have relied solely on underlying cause-of-death data, which may underestimate the magnitude of asthma-related mortality. We used multiple cause-of-death data to examine asthma-related mortality trends in the United States. METHODS: Data were selected from the United States Multiple Cause-of-Death Files ...
The analysis highlighted, as expected, high values of the ASPR for all the AIDS-defining conditions, which are rare among non-AIDS/HIV deaths. The condition most strongly associated with AIDS was toxoplasmosis (ASPR = 4,167; 95% CI: 583.4-29,769.1), in addition to other AIDS-defining infections such as criptococcosis (ASPR = 480.4; 95% CI: 192.1-1,201.2), other mycobacterial infections (other than tuberculosis and Hansen disease; ASPR = 330.3; 95% CI: 157.4-693) and pneumocystosis (ASPR = 208.1; 95% CI: 129.6-334.2). Besides infectious diseases, a very strong association was observed for Kaposi sarcoma (KS; ASPR = 298.9; 95% CI: 162.4-550.1) and -although with lower ASPR values compared to KS- diffuse and other/unspecified non-Hodgkin lymphoma (NHL; ASPR = 14.1 and 6.5, respectively), cachexia (ASPR = 3.9), and cervical cancer (ASPR = 2.8).. Among non AIDS-defining diseases, the infectious conditions with the highest ASPR were leishmaniasis (ASPR = 188; 95% CI: 39.5-894.1) and chronic viral ...
Although the rate of death (deaths per 100,000 people) from cardiovascular disease declined by 29% between 2001 and 2010, its still the leading cause of death in the USA, says the report. One out of three deaths in the United States is caused by cardiovascular diseases.. These findings are really striking because we are talking about hundreds of thousands of deaths that dont have to happen when they happen, says Thomas Frieden, director of the CDC.. Preventable/avoidable deaths. The current life expectancy in the USA is age 78 so if people died sooner than that it is considered early or premature, says the lead author Linda Schieb, a CDC epidemiologist. Preventable/avoidable deaths are the deaths from heart disease and stroke in people under age 75. If their risk factors (smoking, blood pressure, high cholesterol, obesity, physical inactivity) had been under control they should have lived longer. Such risk factors can be easily avoided by bringing changes in lifestyle and hence these deaths ...
Lovely Muthiah, Jovita Dsouza, Abbasi Kanwal and Biji Thomas George-Temperomandibular Disorder Related Causes - A Short Communication
Part two in a series, sharing information you can use to empower yourself when dealing with health professionals who seem more interested in the speed of their diagnosis than on figuring out whats really going on, today a differential diagnosis algorithm devised for docs to use to rule out other medical causes of psychosis in kids. The…
Depression is a prevalent and disabling mental disorder that frequently co-occurs with a wide range of chronic conditions. Evidence has suggested that depression could be associated with excess all-cause mortality across different settings and populations, although the causality of these associations remains unclear. We conducted an umbrella review of systematic reviews and meta-analyses of observational studies. PubMed, PsycINFO, and Embase electronic databases were searched through January 20, 2018. Systematic reviews and meta-analyses that investigated associations of depression and all-cause and cause-specific mortality were selected for the review. The evidence was graded as convincing, highly suggestive, suggestive, or weak based on quantitative criteria that included an assessment of heterogeneity, 95% prediction intervals, small-study effects, and excess significance bias. A total of 26 references providing 2 systematic reviews and data for 17 meta-analytic estimates met inclusion criteria (19
The annual UK snapshot says there has been very little overall improvement in diabetes provision in the past year and that some aspects of care have got worse.. http://www.bbc.co.uk/news/health-30792848. ...
via Change.org My partner Scott and I should have been sharing our son Edward Gilis first birthday last month. But instead of having that exciting first year to celebrate and many more to look forward to, we had just 9 precious days to spend with our beautiful son. Edward was cruelly taken from us as a result of…
Poisoning from prescription or illicit drugs is one of the leading causes of death from unintentional injury in the United States. The Centers for Disease Control and Prevention (CDC) analyzed data from 1999 to 2004 and found that the annual deaths from poisoning had increased 62.5 percent.
Andrew Pickerings Constructing Quarks claims that the scientific communitys evaluation of atomic parity violation experiments was determined by career considerations, and not the quality of the experimental observations. This essay argues that scientists had good evidential reasons to accept atomic parity violation as a strong confirmation of the Weinberg-Salam Standard Model of weak interactions.
How long is modern medicine going to go on casting a blind eye to nutritional medicine before millions of lives are lost? The hope of a vaccine looms, but is months away. Even with a 100% vaccination rate and 100% vaccine effectiveness, by my calculations it is likely such a vaccine would generate more hospitalizations and deaths than the disease itself because of the weak immune status of the individual.. Risk of infection is low and death is nil.. Among healthy adults the risk for infection is very, very small, and the risk for death is almost nil - - in China 3000 (avoidable) deaths in 58 million or 5 in 100,000). Infection and mortality rates are much lower in the U.S. Most of those deaths were among fragile, unhealthy adults over age 70.. The number of reported cases of infection may be far lower than what actually occurs because some patients may never come in contact with the medical care system and recover at home, some only experiencing a mild fever or never even exhibiting symptoms ...
Data & statistics on Standardised mortality rate from external causes per 100000: Standardized death rates from external cause injury and poison, all ages, per 100 000, EU-15, Standardized death rates from external cause injury and poison, all ages, per 100 000, EU-12, Trends in mortality from external causes among males...
Objectives: This study evaluated trends in 30-day, 1-, and 2-year cause-specific mortality using a large, contemporary cohort undergoing...
INE. Instituto Nacional de Estadística. National Statistics Institute. Spanish Statistical Office. El INE elabora y distribuye estadísticas de España. Este servidor contiene: Censos de Poblacón y Viviendas 2001, Información general, Productos de difusión, España en cifras, Datos coyunturales, Datos municipales, etc.. Q2016.es
People trying to make sense of coronavirus are bombarded with data, numbers and graphs. Heres advice to help you sift through it all.
People trying to make sense of coronavirus are bombarded with data, numbers and graphs. Heres advice to help you sift through it all.
Drowsy driving is dangerous and potentially deadly. If youre already behind the wheel when you start to feel drowsy, the best remedy is to pull over and have a 15 minute powernap. You may think you can push through drowsiness, but you cant fight sleep. All day, sleep inducing chemicals
Provides a guide to data on deaths resulting from drug use. It is designed to assist researchers and analysts in utilising Causes of Death data produced by the Australian Bureau of Statistics (ABS). Issues discussed include ABS terminology and classifications used to code drug deaths. ...
Dear Department of Internal Affairs,. In DIAs capacity as overseeing Births, Deaths and Marriages, I wish to know:. Has cannabis use or overdose ever been listed as a cause of death for a New Zealand citizen or resident?. Yours faithfully,. Nicolas Bosma. ...
View Notes - List_of_Rates from PB HLTH 140 at Berkeley. SUMMARY OF RATES DEATH RATES Crude Death Rate Toma Deaths Death Rate 0 POP Itim x 1000 Crude Death Rate for Cause Total Tuberculosis
Each year, ∼100 countries worldwide report data from their vital registration systems on causes of death in their populations 4. The quality and coverage of these statistics vary enormously, yet they are of major relevance for public health. Vital registration systems that capture all deaths in a population, and include a medical certificate completed by a qualified practitioner as to the medical conditions preceding death, are the gold standard for assessing causes of death. Yet, in many countries, these systems either fail to capture all deaths, fail to provide a specific clinical diagnosis as to the underlying cause of death, or provide an incorrect cause. This is true even for developed countries. Thus, many deaths coded to heart failure or ventricular dysrythmias, for example, in countries such as Japan, Spain or France would, in the USA, UK or Australia, be more likely to be recognised as due to ischaemic heart disease 1. The implications of such miscoding can be substantial. For ...
Stretch marks can form as a result of weight gain, muscles and pregnancy. Watch this video to find out various causes of stretch marks.
The analysis of the demographic dynamism of the population and its evolution over time rests on the implementation of demographic statistical operations whose main update sources are the Civil Registers, a census-type administrative register ...
In a nation that is quick to tout its health care system as the best in the world, troubling signs have emerged that should give pause to those who craft public policy.
Newton, JR, Wylie, CE, Proudman, CJ, McGorum, BC and Poxton, IR (2010) Equine grass sickness: are we any nearer to answers on cause and prevention after a century of research? ...
Causes Allergy Articles: Get information on Causes Allergy. Read articles and learn about all the facts related to Causes Allergy from our health website Onlymyhealth.com.
A Detailed Insight on Causes and Symptoms of Piles. Are you suffering from bleeding around your anus for some days? Dont get any tension.
Mafia Mafia Expert (253), on a vote 4 years ago Sorry for, perhaps, a profanity question. Im quite far from medicine, as a consequence and do not understand its subtleties. Could it be lethal
GMWKI Total Deaths for Each Cause by 5-Year Age Groups, United States, 1999-2006. GMWKHI Deaths from Each Cause, by 5-Year Age Groups, Hispanic Origin, Race for Non-Hispanic Population, and Sex: United States, 1999, 2002-06. GMWKIV Deaths from Each Cause by Month, Race, and Sex: United States, 1999-2006. GMWK14 Average Number of Deaths And Total Number of Deaths by Day of the Week, for Selected Causes: United States, 1999-2007. GMWK304 Deaths from Selected Causes, by Date of Death: United States, 1999-2007. GMWK305 Deaths from Selected Causes, by Date of Death: United States, 1999-2007. GMWK306 Deaths from Selected Causes by Age Groups and Date of Death: United States, 1999-2007. GMWK307 Deaths from 39 Selected Causes by Place of Death, Status of Decedent When Death Occurred in Hospital or Medical Center, and Age: United States, 1999-2005. GMWKIII Deaths from 358 Selected Causes by 5-Year Age Groups, Race, and Sex: Each State and the District of Columbia, 1999-2007. GMWK12 Death Rates for 358 ...
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Some have wondered how other diseases mortality (death statistics) compares with COVID-19. To illustrate, their questions can be stated somewhat like on an annualized basis, how many deaths have historically occurred because of X disease when compared to COVID-19? Such a comparison examines ONLY death. It does not examine risk. Its akin to asking who…
SNP rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in type 2 diabetes. The effect of this SNP on mortality was investigated among 1,242 White subjects with type 2 diabetes from the Joslin Kidney Study (JKS, n=416) and the Gargano Mortality Study (n=826). During a mean follow-up of 12.8 ± 5.8 and 7.5 ± 2.2 years, respectively, a total of 215 and 164 deaths were observed in the two studies. In both cohorts, all-cause mortality rate significantly increased with the number of rs10911021 risk alleles, with allelic HRs of 1.32 (95% CI 1.07-1.64, p=0.01), 1.30 (1.10-1.69, p=0.04), and 1.32 (1.12-1.55, p=0.0011) in the JKS, GMS, and the two studies combined, respectively. These associations were not affected by adjustment for possible confounders. In the JKS, for which data on causes of death were available, the HRs for cardiovascular mortality was 1.51 (1.12-2.04; p=0.0077) as opposed to 1.15 (0.84-1.55; p=0.39) for ...
Assault (X85-Y09, Y87.1) accounted for 190 deaths in 2011. The deaths from assault represented 0.1% of all registered deaths and 2.1% of all external causes of death in 2011. Almost twice as many males (120) as females (70) died from assault in 2011, closely following the trend since 2001. The median age at death for assault was 40.1 years. Median age at death for males was 40.5 years, compared with 37.5 years for females ...
Using SWAT officers to storm into homes to execute search warrants has led time and again to avoidable deaths, gruesome injuries and costly legal settlements.
Using SWAT officers to storm into homes to execute search warrants has led time and again to avoidable deaths, gruesome injuries and costly legal settlements.
Our plan is to work with researchers at varous institutions of higher learning in the developed, developing and under-developed world who may wish to join forces with our network to reduce the burden of escalating avoidable death and poverty due to special pathogens. Please fill free fill our membership forms in the website so we can work together in this mision. Read more... ...
An anonymous reader writes: According to new research from the CDC, 9.8% of deaths in working-age adults (22-64 years old) in the U.S. from 2006 to 2010 were attributable to excessive drinking. This makes excessive drinking the fourth leading cause of preventable death in the U.S. The study inclu...
Define proportional mortality. proportional mortality synonyms, proportional mortality pronunciation, proportional mortality translation, English dictionary definition of proportional mortality. adj. 1. Forming a relationship with other parts or quantities; being in proportion. 2. Properly related in size, degree, or other measurable...
Background: Incomplete information on death certificates makes recorded cause-of-death data less useful for public health monitoring and planning. Certifying physicians sometimes list only the mode of death without indicating the underlying disease or diseases that led to the death. Inconsistent cause-of-death assignment among cardiovascular causes of death is of particular concern. This can prevent valid epidemiologic comparisons across countries and over time. Methods: We propose that coarsened exact matching be used to infer the underlying causes of death where only the mode of death is known. We focus on the case of heart failure in US, Mexican, and Brazilian death records.Results Redistribution algorithms derived using this method assign the largest proportion of heart failure deaths to ischemic heart disease in all three countries (53%, 26%, and 22% respectively), with larger proportions assigned to hypertensive heart disease and diabetes in Mexico and Brazil (16% and 23% vs. 7% for ...
Recent evidence from the UK has also questioned the use of SMRs as a marker. A review requested by National Medical Director of the NHS Commissioning Board Sir Bruce Keogh used hospital-wide SMRs to select acute Hospital Trusts in England for detailed consideration of their quality. This review was established in February 2013 in the wake of the second Francis report into the Mid-Staffordshire NHS Foundation Trust.. The 14 Trusts selected had a higher than expected hospital-wide SMR for two consecutive years. In July 2013, one of the main recommendations of the review was the need for a study into the relation between excess mortality rates based on SMRs and actual avoidable deaths. Avoidable deaths was considered by some to be a more meaningful quality care indicator, as it was based on a detailed review of deaths by clinicians, rather than statistical probability derived from routine data. The group that undertook the study had already published a paper (PRISM 1), which stated the ...
Health Reports, volume 23, number 3. Cause-specific mortality by education in Canada: A 16-year follow-up study. Table 4 Age-standardized mortality rates per 100,000 person-years at risk for selected causes of death, by educational attainment, age group and sex, cohort members aged 25 or older at baseline, Canada 1991 to 2006
TY - JOUR. T1 - Light cigarette smoking increases risk of all-cause and cause-specific mortality. T2 - Findings from the nhis cohort study. AU - Qin, Wen. AU - Magnussen, Costan G.. AU - Li, Shengxu. AU - Steffen, Lyn M.. AU - Xi, Bo. AU - Zhao, Min. PY - 2020/7/2. Y1 - 2020/7/2. N2 - Very few studies have examined the association between light cigarette smoking(i.e.,≤5 cigarettes per day) and mortality. The aim of this study was to examine the association of light cigarette smoking with all-cause and cause-specific mortality among adults in the United States. Data were from 13 waves of the National Health Interview Survey (1997 to 2009) that were linked to the National Death Index records through December 31, 2011. A total of 329,035 participants aged ≥18 years in the United States were included. Deaths were from all cause, cancer, cardiovascular disease (CVD) and respiratory disease and were confirmed by death certification. During a median follow-up of 8.2 years, 34,862 participants died, ...
With the news of Scott Weilands death surfacing late last night, not much was known at the time. The former Stone Temple Pilots and Velvet Revolver frontman was found dead on his tour bus last night. Weiland was on tour in Minnesota with his solo band The Wildabouts when he was found.. Weiland has had well-documented substance abuse issues, previously kicking a serious heroin addiction. TMZ obtained audio of the emergency call and dispatchers said the singer was not breathing and his immediate cause of death was cardiac arrest. The underlying cause of death has not been determined yet.. TMZ claims that multiple sources in the music industry told them that friends were worrying in the days leading up to his death that he was deep into crack cocaine use and might have died of an overdose. Weilands wife refutes those reports saying he has been sober off drugs for years, that his band has a pact to do no drugs on tour and he had only been drinking socially in recent years.. Update: According to ...
There is a large margin of error in death statistics. Mortality statistics for cerebrovascular disease show, however, the well-known rise in frequency with age, the higher frequency in men than women which is likely to affect all countries in the coming years, and the greater involvement of nonwhite Americans and Japanese than of white Americans and Japanese Americans. I believe that incidence figures, when they become available in future years, will confirm these findings. Environmental factors, such as a water factor, also relate to cerebrovascular death rates. Possibly the biggest factor in the medical environment, causing artificial swings in both mortality and incidence figures, will be shown to be the changing diagnostic habits of physicians.. From the viewpoint of etiology, the coexistence of hypertension and cerebrovascular disease dominates the epidemiological picture. The geographic distribution of cerebrovascular mortality in the U.S.A., and the higher mortality in Negroes and in ...
Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240
First, of all, it isnt a count of deaths each year from flu. We dont know how many people die of seasonal influenza each year because there is no list we can use to count them. Why not just use the death certificate information? You can see what a death certificate looks like here. The Cause of Death section has two parts. Part I. asks for the immediate cause of death (first line) and any underlying conditions that brought it about (up to four subsequent lines). The underlying causes are the due to components. Suppose someone dies of gram negative sepsis, a total systemic failure usually caused by a bacterial infection. The lines below the immediate cause are supposed to be the links in the causal chain leading to the sepsis. Bacterial pneumonia would be a typical cause of sepsis, so we have an immediate cause of death of gram negative sepsis due to bacterial pneumonia. Secondary infection by bacteria is a common complication of a respiratory viral infection, so the next line might be viral ...
BACKGROUND: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. METHODS: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174374 deaths or major non-fatal vascular outcomes recorded among 1085949 people in 121 prospective studies. RESULTS: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental
Cause-specific mortality among neurosurgeons. Lollis SS1, Valdes PA, Li Z, Ball PA, Roberts DW. Author information J Neurosurg. 2010 Sep;113(3):474-8. doi: 10.3171/2010.1.JNS091740. Abstract OBJECT: The authors sought to determine a cause-specific mortality profile for US neurosurgeons during the period 1979-2005. METHODS: Neurosurgeons who died during the study period were identified from the Physician Master File…
IHME research used de-identified death records from the National Center for Health Statistics (NCHS) and population counts from the U.S. Census Bureau, NCHS, and the Human Mortality Database and small area estimation models in order to estimate county-level mortality rates from all cardiovascular diseases (CVD), including ischemic heart disease, cerebrovascular disease, ischemic stroke, and other types. This dataset provides estimates for age-standardized mortality rates by CVD type and sex at the county level for each state, the District of Columbia, and the United States as a whole for 1980-2014, as well as the changes in rates for each location during this period. Also included are data on the 10 counties with the highest and lowest mortality rates for each CVD type in 2014 and the top 10 causes of death by CVD type for each county. Study results were published in JAMA in May 2017 in Trends and patterns of geographic variations in cardiovascular mortality among US counties, ...
What are some medical causes for dog aggression? Often, what looks like aggression is simply a dog in pain whose threshold for aggression has lowered.
Data & statistics on Heart Disease Death Rate by Race in Iowa: Heart Disease Death Rate by Race in Iowa, 2001-2005, Age-Adjusted Mortality: Heart Disease (Quad Cities Area by Race; 2001-2003 Deaths per 100,000 Population), Heart Disease Mortality Rates: 2000-2006...
London, United Kingdom, Mar 7 - British pop icon George Michael who was found dead at his home on Christmas Day, died of natural causes, a coroner announce - Kenya breaking news | Kenya news today | Capitalfm.co.ke
LONDON • British pop icon George Michael who was found dead at his home on Christmas Day, died of natural causes, a coroner announced.. Read more at straitstimes.com.
The prevalence of class III obesity (body mass index [BMI]≥40 kg/m2) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity.In a pooled analysis of 20 prospective studies from the United States, Sweden, and Australia, we estimated sex- and age-adjusted total and cause-specific mortality rates (deaths per 100,000 persons per year) and multivariable-adjusted hazard ratios for adults, aged 19-83 y at baseline, classified as obese class III (BMI 40.0-59.9 kg/m2) compared with those classified as normal weight (BMI 18.5-24.9 kg/m2). Participants reporting ever smoking cigarettes or a history of chronic disease (heart disease, cancer, stroke, or emphysema) on baseline questionnaires were excluded. Among 9,564 class III obesity ...
Please share this widely. Its absolutely crucial for the future of Stafford hospital and of the wider NHS.An important new academic paper was published this week by the Oxford University Press Oxford Journals on the subject of Hospital Standardised Mortality Ratios (HSMRs). This paper, by a team of respected academics from the Primary Care Clinical…
There are many different ways in which hydrocephalus can manifest itself and it has many different causes. Although people have been aware of the symptoms since ancient times, most of the causes, to use scientific language, are
Dietary fiber intake has been positively linked to the prevention of four of the ten leading causes of death among adults in the United States. The Centers for Disease Control and Prevention (CDC) listed the leading causes of death in 2010 as 1) heart disease, 2) cancer, 3) chronic lower respiratory disease, 4) stroke, 5) accidents, 6) Alzheimers disease, 7) diabetes, 8) nephritis (kidney disease), 9) influenza/pneumonia, and 10) suicides (Murphy, Xu, & Kochanek, 2013). Heart disease was responsible for a proportional mortality ratio (PMR) of 27% of deaths. Stroke was fourth on the list with 6% of deaths (CDC, 2012). Diabetes is also a very serious condition that was responsible for approximately 69,000 deaths in 2010 (Murphy et al., 2013). The serious consequences of the aforementioned conditions have led researchers to study a variety of prevention strategies, including dietary fiber intake.
This book is both precise and poignant. It gives clear examples from real cases about how the medical system has been, and will be, unable to avoid the personal errors of even its most talented members. While doctors are a conscientious and industrious profession as a whole, there are mistakes that are both avoidable and predictable in a system reliant for perfection upon the unattainable perfection of its human beings. Acknowledging that the practice of medicine is a fundamentally human endeavor, filled with doctors having both good and bad days, the author reveals, in personal account, the horrors of inexperienced surgeons, overworked residents, over-ambitious egocentrics, and just plain old human mistakes. He acknowledges that 3,500 avoidable deaths occur each year from anesthesia misphaps alone, and as many as 100,000 avoidable deaths in hospitals per year. While doctor Gawande recognizes the huge statistics of injured patients caused by either inattentive individuals or an inattentive ...
Authorities say an autopsy shows that one of four inmates who died at the Orangeburg County Detention Center over the past nine months died of natural causes.
Overview. SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.. Read Full Overview. ...
GREENSBORO, N.C. - Police say a man who was found dead over the weekend on the side of a Greensboro roadway died of natural causes. Officers responded shortly after 8:45 p.m. Saturday to a report of a man lying on the side of the road at the Creek Ridge overpass at U.S. 220.
OBJECTIVE--To determine the effects of lowering cholesterol concentrations on total and cause specific mortality in randomised primary prevention trials. DESIGN--Qualitative (meta-analytic) evaluation of total mortality from coronary heart disease, cancer, and causes not related to illness in six primary prevention trials of cholesterol reduction (mean duration of treatment 4.8 years). PATIENTS--24,847 Male participants; mean age 47.5 years. MAIN OUTCOME MEASURES--Total and cause specific mortalities. RESULTS--Follow up periods totalled 119,000 person years, during which 1147 deaths occurred. Mortality from coronary heart disease tended to be lower in men receiving interventions to reduce cholesterol concentrations compared with mortality in control subjects (p = 0.06), although total mortality was not affected by treatment. No consistent relation was found between reduction of cholesterol concentrations and mortality from cancer, but there was a significant increase in deaths not related to ...
Comparison of deaths where the coronavirus (COVID-19) was mentioned on the death certificate by broad age group, sex and ethnic group, using linked census and mortality records on deaths registered up to 17 April 2020. Includes death counts, cause-specific mortality ratios, age-standardised rates and odds ratios to identify differential risks of COVID-19-related deaths.
AbouZahr describes ascertainment by interview of (1) cause of death and (2) social, care-seeking and other factors leading to death. These are two quite different challenges with different underlying purposes. The first may be described as verbal autopsy, but the second is more usually described a social autopsy. Social autopsy is rarely conducted but could, as AbouZahr relates, provide very important information about how to break the chain of the road to death, whereby a chain of events, decisions, and circumstances lead to most, if not all, avoidable deaths. That chain could be broken by empowering parents and healthcare providers - including empowerment with basic clinical healthcare knowledge such as recognition of danger signs.. ...
Interview with Fatima Rodriguez, MD, MPH, author of Disaggregation of Cause-Specific Cardiovascular Disease Mortality Among Hispanic Subgroups
Free, official coding info for 2020 ICD-10-CM V80.919 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Free, official coding info for 2020 ICD-10-CM V79.81XD - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
CORONAVIRUS DISEASE 2019 (COVID-19) was among the leading causes of death in the Philippines last year, preliminary data from the Philippine Statistics Authority (PSA) showed.. Registered deaths due to COVID-19 accounted for 27,967 deaths, or 4.9% of the total 575,875 deaths tallied in 2020. This compares with other leading causes of death last year that include ischaemic heart diseases (99,680 deaths), neoplasms/cancer (62,289), cerebrosvascular diseases (59,736), diabetes (37,265), pneumonia (32,574), and hypertensive diseases (29,511).. Deaths associated with COVID-19 are classified into two: those with virus identified and not identified at the time of a persons death.. COVID-19 with virus not identified accounted for 19,758 cases or 3.4% of the total deaths, making it the seventh leading cause of death in the country last year.. Meanwhile, COVID-19 cases with virus identified tallied 8,209 cases or 1.4% of the total, ranking 16th overall.. According to the PSA, figures on COVID-19 ...
A brand new dual stage loader designed to unload overloaded iron ore carts at a BHP mine in Western Australia is wrecked during transport, this happen...
The TAC Medical Excess may apply to these services Policy The TAC will pay the reasonable cost of human donor tissue required for transport accident injuries. Transport Accident Act 1986 reference: s.3 medical service and s.60 Guideline Payment will be made in accordance with the Department of Health and Ageings
A new report on obesity from the Organisation for Economic Co-operation and Development (OECD) makes for grim reading; it details that even just being overweight will slash almost 3 years from life expectancy, on average, with this figure rising to 4 years in the United States (Medscape October 11, 2019), confirming my analysis from 2 decades ago:. Lifetime risk of developing coronary heart disease Sanchez-Delgadoa, Heinz Liechtia Lancet, Volume 353, Issue 9156, Pages 924 - 925, 13 March 1999. We compared caloric intake with life expectancy in the 20 most developed countries and found that, an ingestion of 280 kcal less every day corresponds to 25 months longer lifespan and vice versa.. When we compared prospectively the pulse×mass index with the calculations of cardiovascular disease risk factors according to the Framingham Heart Study, the correlation was highly significant (r=0•94; ...
mportance The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. Objective To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged ,5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Evidence Review Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was ...
Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially lifting costs to health systems. The Global Burden of Disease 2016 Study provided an assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016.. Deaths from noncommunicable diseases represented 72.3% of all deaths in 2016, with 19.3% of deaths in that year occurring from CMNN diseases.. In 2016, the three leading global causes of death in children under five were lower respiratory infections, neonatal preterm birth complications and neonatal encephalopathy because of birth asphyxia and trauma.. Between 1990 and 2016, a shift toward deaths at older ages occurred, with a 178% increase in deaths in ages 90 and 94 years and a 210% increase in deaths older than age 95 years.. The 10 leading causes by rates of age-standardized YLL declined from 2006 to 2016; the median annualized rate of change for all other ...
County population figures and death statistics are acquired using CDC WONDER from the Underlying Cause of Death database. Conditions were queried for years 2006-2010 based on a selection of codes from the International Classification of Diseases (ICD), Version 10. The ICD-10 is the current global health information standard for mortality and morbidity statistics. The ICD has been maintained by the World Health Organization since its conception in 1948. A searchable, detailed list of current ICD- 10 Codes (Version 2010) is available from the World Health Organization.. Mortality rates were acquired from the source age-adjusted to the year 2000 U.S. standard. To recalculate age-adjusted mortality rates for unique service areas and aggregated county groupings, the following formula was used ...
BackgroundSocioeconomic inequalities in death rates from all causes combined widened from 1960 until 1990 in the U.S., largely because cardiovascular death rates decreased more slowly in lower than in higher socioeconomic groups. However, no studies have examined trends in inequalities using recent US national data.Methodology/Principal FindingsWe calculated annual age-standardized death rates from 1993-2001 for 25-64 year old non-Hispanic whites and blacks by level of education for all causes and for the seven most common causes of death using death certificate information from 43 states and Washington, D.C. Regression analysis was used to estimate annual percent change. The inequalities in all cause death rates between Americans with less than high school education and college graduates increased rapidly from 1993 to 2001 due to both significant decreases in mortality from all causes, heart disease, cancer, stroke, and other conditions in the most educated and lack of change or increases among the
Preventable deaths are those deaths that could have been avoided by effective public health interventions along with a focus on the wider determinants of health, such as socioeconomic conditions and environmental factors. The reduction of avoidable deaths, including deaths considered preventable or treatable, is an important population health goal and a key indicator in
Chronic lower respiratory disease, including chronic bronchitis, asthma and emphysema, killed 160,201 people in 2017. In 2005, longtime Tonight Show host Johnny Carson died from respiratory failure caused by emphysema.
Walshs original tweet was completely reasonable, pointing out the absurdity of maintaining strict COVID lockdowns now that the COVID death rate has plummeted.. COVID is here to stay. Youre going to get it. It almost certainly wont kill you but it could. Youll probably get cancer eventually too unless you die first. Lots of scary things out there. Death is certain. Suffering is unavoidable. Stop cowering. Live your life while you can, Walsh wrote.. If you buy into the coordinated pandemonium coming from establishment media outlets and left-wingers, you might think that COVID-19 remains one of the greatest existential threats facing American existence today.. However, a quick look at the facts proves that, at this moment in time, the threat posed by COVID is negligible.. According to the Peterson Center on Healthcare, in June 2021, COVID-19 was just the seventh-leading cause of death in the U.S.. Heart disease, cancer, accidents, stroke, chronic lower respiratory disease and Alzheimers ...
What are the biggest risks to our lives? Some are overblown. What are the major risks to our lives? If we look at the statistics of what claims lives, some of our collective fears look unfounded. According to the Centers for Disease Controls most recent tally, 614,438 Americans died of heart disease in 2014, and another 591,699 from cancer. Chronic lower respiratory diseases (not including the flu and pneumonia) took 147,101 lives in that year, while 136,053 people died accidental deaths. Strok
The aim of the study was to develop and implement the most accurate methods for evaluating perinatal losses in women with extracorporal fertilization.
Loving the retro color palette and excellent type styling in this infographic on causes of and treatments of excess perspiration. #excesssweat #infographic #sweattreatments
On Tuesday, Darren Salter, the senior coroner in the southern English county of Oxfordshire, says the official cause of Michael's death was “dilated cardiomyopathy with myocarditis and fatty liver.”
The U.S. Centers for Disease Control and Prevention (CDC) recommends this for everyone aged 13-64 regardless of symptoms, but HIV infection is a common cause of neuropathy, so testing should be strongly considered when neuropathy is diagnosed. HIV is highly prevalent in the developing world. Only 1 in 5 of people living with HIV know their status and only 1 in 4 are receiving adequate care. In the United States about 1.2 million people are living with HIV and 50,000 cases are diagnosed every year. Thus, HIV along with its complications- including HIV neuropathy- is a concern in the health providers community. The first test is antibody screening (ELISA). If positive, it is confirmed by testing for the viral protein. Early diagnosis is important as treatment can improve symptoms and reduce long-term damage. HIV patients well-managed on antiretroviral medications do very well and have the same life expectancy as normal individuals. However some antiretroviral medications themselves can cause ...
The mortality of our study participants, including both vegetarians and nonvegetarian health-conscious persons, was very low (SMR, 59) compared with the general population in Germany after a follow-up of 21 years. This was predominantly due to a large deficit of deaths from circulatory diseases, which accounts for about 50% of all deaths in the general population. The greater reduction of deaths from malignant neoplasms among men than in women is predominantly attributable to the large deficit of lung cancer, the leading cause of cancer deaths among men. The virtual absence of smoking in this study population probably explains much of the scarcity of deaths from lung cancer and respiratory diseases as well as in part that of circulatory diseases.. The mortality analysis by time since entry into the study indicated an initial weak healthy participant effect but the mortality remained low. The SMR for all-cause mortality increased for men over the years, whereas among women the SMR reached a ...
Death. (BrUp 1.2.7. trans. Müller) God of death implicitly, in eṣa vā aśvamedho ya eṣa tapati "verily, that Ashvamedha is that ... Mara (Hindu goddess), the goddess of death according to Hindu mythology. Mṛtyu-māra as death in Buddhism or Māra, a "demon" of ... Mṛtyu (from Vedic Sanskrit: मृत्यु IAST:mRtyu ; Latin cognate mortis), is a Sanskrit word meaning Death. Mṛtyu or Death is ... Yama (Sanskrit: यम) is the lord of death in Hinduism and Buddhism. Yama in Hinduism. Yama in Buddhism. Vedic mṛtyú, along with ...
CS1 maint: discouraged parameter (link) "Death of an Artist". The New Zealand Times (9894). Wellington, New Zealand. 27 April ... ISBN 978-1-86940-771-1. "Death". The Colonist (7630). Nelson, New Zealand. 15 May 1893. p. 1 (supplement). Retrieved 6 ...
p. 2. "Death". Auckland Star. XXI (4122). 20 September 1883. p. 2. Retrieved 31 January 2019. v t e. ...
"Death of Mr Francis Jollie". The Timaru Herald. XIII. 3 December 1870. p. 2. Retrieved 13 July 2012. "Married". Lyttelton Times ... "Death". Lyttelton Times. XXXIV (3088). 3 December 1870. p. 2. Retrieved 1 March 2019. Holm, Janet (2005). Caught Mapping: The ...
p. 2. "Death". Waikato Times. XLI (3315). 26 September 1893. p. 4. Retrieved 23 February 2014. "Local and General". The Star ( ... "Death". The Timaru Herald. LV (5743). 8 August 1893. p. 2. Retrieved 23 February 2014. "Marriages". The Star (5733). 28 ... "Deaths". The Press. LXVII (14051). 24 May 1911. p. 1. Retrieved 22 February 2014. Harper, Margaret. "Christchurch Street Names ...
"Death". Grey River Argus. 16 September 1881. "Death". Marlborough Express. 16 September 1881. "Statue". The Press. 26 September ... Moorhouse was elected to represent Akaroa in the 1st New Zealand Parliament, and remained an MP until his death. In his ...
After Renwick's death, his wife lived there until 1937. Later, the house became known as Renwick House. Still standing, it is ... "Death". Nelson Evening Mail. XIV (274). 29 November 1879. p. 2. Retrieved 3 November 2020. Reed, A. W. (2010). Peter Dowling ( ... They arrived in Nelson on 25 October 1842, with two children having died on the voyage (which is considered a low death rate). ...
Darpan, Pratiyogita (August 1998). "Death". Competition Science Vision. p. 792. Miles, Dick (6 May 1968). "The Channel Is a ...
ISBN 978-0-473-36572-1. "Death". Auckland Star in Papers Past. 15 January 1892. "Funeral". Thames Star in Papers Past. 15 ...
"Death". Hokitika Guardian. 17 November 1928. p. 4. Retrieved 27 September 2020.. ...
Death? Of course I think of it. But I don't want to dwell on it ... I think the thing you think about when you're my age is how ... Grant on death, later in life. Grant was at the Adler Theater in Davenport, Iowa, on the afternoon of Saturday, November 29, ... I'm going to lie in bed…. I shall just close all doors, turn off the telephone, and enjoy my life". Grace Kelly's death was the ... Grant became a fan of the comedians Morecambe and Wise in the 1960s, and remained friends with Eric Morecambe until his death ...
Death.' to the C.H.A.O.S. Split album released on July 20, 2017 through Art of Propaganda. The album was dedicated to the ... There's no conformity involved as far as genres-black metal, death metal, whatever. I just write riffs that feel right to me. ... Though the band's style can be broadly categorized as blending elements of death metal or black metal, critics have noted the ... muddy blast-beat death/black metal succeeds and it's succeeded by abysmal doom metal passages." NPR Music compared the EP to ...
Death; 2. Imprisonment; 3. Fine; 4. Removal from office; or, 5. Disqualification to hold and enjoy any office of honor, trust, ...
Death: the inevitability of death" and then pulled a newspaper cutting from his pocket and read out the following quote from de ... meaning death, release from deathlessness, and explains "Through death, men can let go; in their deathlessness, elves cannot. ... All men must die, but for every man his death is an accident, and even if he knows it and consents to it, an unjustifiable ... He finally took his death (for those kings had the freedom and grace to die at will) at the age of five hundred. The ...
"Death Resolution: Senator Tony Gabaldon". AZleg.state.az.us. January 1998. Retrieved November 21, 2013. Eckman-Onyskow, Bev ( ... Death. Sex. Heartbreak". GRRM.livejournal.com. Archived from the original on February 14, 2015. Retrieved September 18, 2014. " ... DeNardo, John (January 14, 2010). "Songs of Love and Death edited by George R.R. Martin and Gardner Dozois". SF Signal. ... "Pocket Releases Songs of Love and Death". GeorgeRRMartin.com. November 24, 2010. Retrieved September 18, 2014. Martin, George R ...
"Death. William Henry Gebhard Jr. of scarlet fever, youngest son of late Frederick C. Gebhard, aged 10 years". The New York ... They were each entitled to 1/24th part of this estate plus a part of their aunt Nora's share due to her death in 1874. Her ... "FREDERICK NEILSON'S DEATH. THE FATAL ILLNESS OF THE POPULAR SOCIETY MAN" (PDF). The New York Times. July 29, 1887. Retrieved 21 ...
Mea'ole died a year later in 1963, leaving Tanumafili as the sole holder of the office until his death in 2007, aged 94. His ... death. The position is that of a ceremonial Head of State, while actual power is held by the Prime Minister, whom the Head of ...
Death". When Finlander tries to justify sinking the Novosibrsk because "war is hell", Commodore Schrepke replies "a nuclear ... Does it not all naturally culminate in the totality of death and destruction?...Look and see what the Cold War really is. The ... leading the latter to embark upon a course that leads to the deaths of everyone abroad the Bedford. Munceford comes to serve as ... anti-Communism and relentless determination to provoke a confrontation with a Soviet submarine that leads to the deaths of ...
Death? Get over it". SFX. Retrieved 14 July 2011. CS1 maint: discouraged parameter (link) The New World on Tardis Data Core, an ...
zimbabweournalists.com details of death Jan Raath, "Double cross turns tables on Mugabe militia", The Times, 24 October 2003, p ... Death." [1] On taking up his office, Dr Jokonya offered regular meetings with journalists to discuss their coverage. He told ... "Jokonya death: Family rules out foul play", Zimbabwe Herald, 26 June 2006. ...
... (born 28 July 1902; death:?) was member of Indian National Congress, who served as a member of Indian ...
Death. Irvin, Zuri (January 17, 2016). "Writing Jokes with Allie Goertz". Medium. Retrieved June 28, 2019. Kremkau, Bryan ( ...
"Death of Mr John White". West Coast Times (2322). 6 September 1876. p. 2. Retrieved 8 March 2014. Scholefield 1950, p. 243. ... "Death". Grey River Argus. XXXVIII (6773). 2 June 1890. p. 2. Retrieved 8 March 2014. "Wellington News". The Star (6869). 3 June ... "Death of another Legislative Councillor". Ashburton Guardian. XII (2430). 2 June 1890. p. 2. Retrieved 8 March 2014. ... He was a member of the New Zealand Legislative Council from 9 July 1872 until his death. Lahmann died aged 74 on 1 June 1890 at ...
"Death". The Nelson Evening Mail. XXIII (325). 24 December 1889. p. 2. Retrieved 21 June 2015. Sources Richardson, Lesley (1995 ...
After her death he falls deeply in love with Sasha, an elusive and somewhat feral princess in the entourage of the Russian ... Death? Marriage?". For Woolf herself, the book was compensation for a sense of loss. Woolf was often hurt by Sackville-West's ... her constraining female clothes and an incident in which a flash of her ankle nearly results in a sailor's falling to his death ...
"Death". Free BMD. "History" (PDF). All England Badminton. Matthews/Morrison, Peter/Ian. The Guinness Encyclopaedia of Sports ...
"Death" - Transition. Change. Death. - The Last Day of Pompeii by Karl Brullov. "King of Swords" - A powerful commander. A wise ... Madness, or even death. [...] The only way to receive the full measure of the boon is if it's freely granted, in sound mind, by ... Upon his death, the Prince shall rise.' - The Prince, that's me. Management was the Prophet. It's all in this book. He needed ... Upon his death, the Prince shall rise," and "[Behold the Usher. A dark heart dwells where branches meet.] Anointed dagger ...
"Death". Colonist. XXXV (7404). 18 August 1892. p. 3. Retrieved 2 February 2016. "Secondary schools". Cyclopedia of New Zealand ... "Births, Marriages, and Deaths". Wellington Independent. XXI (2480). 14 February 1867. p. 4. Retrieved 2 February 2016. "Married ...
DEATH. LIARDET.- On the 21st March, at Vogeltown, W. F. Evelyn Liardet, aged 79 years, father of Mr. Hector and Sinclair ... "DEATH OF MR. JOHN EVELYN LIARDET". The Sydney Morning Herald. National Library of Australia. 30 October 1902. p. 7. Retrieved ...
"Death". The Press. III (294). 9 October 1863. p. 2. Retrieved 8 June 2016. Greenaway, Richard L. N. (June 2007). "Barbadoes ...
Fourth, our estimate of influenza-associated deaths relies on information about location of death from death certificates. ... However, death certificate data during the 2018-2019 season were not available at the time of estimation. We have used death ... Furthermore, our model uses the frequency of influenza-related deaths that have cause of death related to pneumonia or ... Influenza-associated Pediatr Deaths Identified Through Minnesotas Unexplained Critical Illness and Death Project - Minnesota, ...
This report describes the number and rate of heat-related deaths that occurred in the United States during 2004-2018. ... This report describes the number and rate of heat-related deaths that occurred in the United States during 2004-2018. ... Alcohol poisoning deaths were identified using underlying cause-of-death codes X45, X65, and Y15. Drug overdose deaths were ... deaths from ischemic heart diseases, 438 (10%) deaths from hypertension, and 773 (18%) deaths from alcohol poisoning and drug ...
17 The death certificate database includes all deaths in Ontario. Causes of death were determined from death certificates, ... Mean age at death was 39 years. Among women 18-44 years of age, the most common causes of death were HIV/AIDS and drug overdose ... 31, 1997, or, in the case of decedents, date of death.14,17 Mortality rates were calculated by dividing the number of deaths by ... Deaths in the study population were ascertained by comparing the database of shelter users with Ontario death certificate ...
I have done many studies and research on opioid deaths and what I found is very few opioid deaths are caused by prescription ... that accounts for 1,000X greater fatalities/deaths (and OD deaths) than ANY Physician-prescribed opiate regime EVER has -or ... Most opioid deaths are from illegal fentanyl opioid drugs. This is not fair to the millions of legitimate people in pain suffer ... Deaths from opioids have been rising sharply for years, and drug overdoses already kill more Americans under age 50 than ...
A fact sheet that describes the incidence and death rates for selected cancers among racial and ethnic groups living in the ... The lowest death rates for prostate cancer are found in Asian/Pacific Islander men. Incidence and death rates for prostate ... The highest death rate from cervical cancer is among African American/Black women. Incidence and death rates for cervical ... For all cancers combined, the death rate is 25 percent higher for African Americans/Blacks than for Whites. Incidence and death ...
3: Alzheimers doesnt lead to death.. Sadly, its the sixth leading cause of death in the U.S. Most people live 8 to 10 years ...
... a death rate of 1 in 24,000 translates to 1.5 deaths per day (541 children annually); while a death rate of 1 in 500,000 ... Death rate is likely to be significantly higher from non-medicalized circumcisions performed at home, en masse, and/or under ... Estimated Number of Circumcision-Related Deaths. (based on 1994 world estimate of circumcised males: 647,701,200). 1,295 to ... male circumcisions performed, or the number of circumcision-related complications or deaths. ...
Ryuks Death Note is found by an honors student named Light Yagami. At first he doesnt believe the Death Note is for real, but ... Death Note, on Nippon TV ANN; Characters Database; Hulu; IMDb; Madman; TV.com; TV Tropes; VIZ; Wikia; Wikipedia Caution: ... Oh, and you might want to check out Bad Horse Death Note, by Tom Smith. Its a very short song about this series, to the tune ... And the deaths all benefit the Yotsuba Corporation. There is a group of eight members of the corporation who have regular ...
... When an U.S. citizen dies abroad, the Bureau of Consular Affairs assists the family and friends. The Bureau of ... For more information on the Consular Report of the Death of an American Abroad, and other services that a consular officer can ... Upon issuance of a local (foreign) death certificate, the nearest embassy or consulate may prepare a Consular Report of the ... citizen who dies abroad if the deceased has no legal representative or next-of-kin in the country where the death occurred, ...
Faked death Karōshi Last rites List of deaths by year Memento mori Near-death experience Origin-of-death myth Spiritual death ... Casualty (person) Day of Judgment Day of the Dead Deathbed Death drive Death row Death trajectory Doomsday Dying declaration ... real death is distinguished from reversible death. The leading cause of human death in developing countries is infectious ... Death is part of several key Buddhist tenets, such as the Four Noble Truths and dependent origination. In Hindu texts, death is ...
The Black Death: A Personal History. Black Death. an alternative view.. Was it Haemorrhagic fever, spread by virus, like Ebola? ... Rosemary Horrox - Black Death. original documents - essential reading. John Hatcher - The details of the epidemic in a Norfolk ... The death of birds suggests Bird Flu. The fact that Iceland was affected, even though there were no rats there at that time, ... However, if Black Death was a virus like Ebola or Marburg, a repeat is possible. At present these viruses are so rare that ...
The man, still walking down the highway, meets Death. The man decides to make Death the childs godfather saying that Death ... If Death stands at the persons head, that person is to be given the special herb found in the forest, and cured. But, if Death ... The next Sunday, Death becomes the childs godfather. When the boy comes of age, Death appears to him and leads him into the ... Death explains that the length of each candle shows how much longer a person has to live. When Death shows the physician his ...
"Death Valley Weather". US National Park Service.. *^ a b c "Weather and Climate". Death Valley National Park. U.S. National ... Death Valley. NPS.gov. Retrieved 29 May 2009.. *^ Masters, Jeff. "Historic Heat Wave Reponsible(sic) for Death Valleys 129°F ... "Death Valley" (2013), a song from the studio album Save Rock and Roll by Fall Out Boy, is named after Death Valley, as well as ... Death Valley (TV series), a 2011 MTV horror comedy series[42]. *Death Valley Days (1930-1945 radio series; 1952-1970 TV series ...
Eternal Death at AllMusic. Retrieved 26 March 2021. Snow, Drew (14 July 1997). "Crown of Thorns - _Eternal Death_". Chronicles ... CS1 maint: discouraged parameter (link) Heaton, Dave (29 March 2015). "Eternal Death: Eternal Death". PopMatters. "Review: The ... Eternal Death is the second album of Crown of Thorns. It was originally released in 1997 and later re-issued under the bands ... "THE CROWN - ETERNAL DEATH". CrossFire. Retrieved 26 March 2021. CS1 maint: discouraged parameter (link) v t e. ...
Death in Sanatorium B.J. Winslow - Death in Morgue Joan Farrell - Traci The New York Times DVD Talk Death Tunnel at IMDb Death ... Death Tunnel is a 2005 horror movie filmed at the Waverly Hills Sanatorium. It stars Steffany Huckaby, Annie Burgstede, Kristin ...
Death anxiety may refer to: Existential angst The Sickness Unto Death & The Concept of Anxiety, psychological works on angst by ... by the group Bleeding Through This disambiguation page lists articles associated with the title Death anxiety. If an internal ... theory that says humans are so motivated to deal with their fear of dying that it can affect their beliefs and behaviours Death ... Søren Kierkegaard Death anxiety (psychology) Necrophobia, an abnormal fear of dead things, or the related condition of ...
Texas jurys quick death sentence for John William King, which the WP puts on page 3, while the LAT runs it on page 28. The... ... USAT leads with a Jasper, Texas jurys quick death sentence for John William King, which the WP puts on page 3, while the LAT ... Also, the papers dont mention it, but this story should give pause to anyone who thinks the death penalty is a deterrent. The ... The paper goes on to report that since the Supreme Court reinstated the death penalty in 1976, nationwide eight whites have ...
the death) The collapse or end of something. England scored a goal at the death to even the score at one all. death of the ... death from natural causes), mate whawhati tata (sudden death), mate koeo (natural death), hautapu (by violence) ... death (countable and uncountable, plural deaths). *The cessation of life and all associated processes; the end of an organisms ... often capitalized) The personification of death as a hooded figure with a scythe; the Grim Reaper. When death walked in, a ...
I do not believe it is possible to know how much of his misery at this time was due to malaria, to medicines, or to the death ... David Brown: People with MEN 2B are definitely prone to illness and early death, which is why Lincolns longevity (he died at ... Arlington, Va.: Are individuals with this condition more prone to illness and early death? I notice in pictures of Lincolns ... The first was in connection with the death of Lincolns near-fiancee, Ann Rutledge. (This is a hugely controversial point with ...
Death from Above. The amount of killing in Jagged Alliance may put some people off, but a higher principle is at work, one from ...
Death Note: Directed by Adam Wingard. With Nat Wolff, LaKeith Stanfield, Margaret Qualley, Shea Whigham. A high school student ... Death note should have been adapted in a slightly slower paced film, and had minimal gore (most of people died by heart attack ... Death Notes film adaptation chose this second route. I have the feeling that they didnt understand at all what was the series ... at around 23 mins) When Light shows Mia the Death Note for the first time he asks her to read the last entry. The last entry ...
The crude mortality rate or crude death rate is defined as the ratio of the number of deaths during the year to the average ... The infant mortality rate is defined as the ratio of the number of deaths of children under one year of age to the number of ... Mortality is the number of deaths for a given area during a given period. Infant mortality is the mortality of live-born ... A death, according to the United Nations definition, is the permanent disappearance of all vital functions without possibility ...
What happens after death?. So when it comes to death, what are we sure of? Well we know what happens to your body from the ... Take the tragic deaths of people caught in the 9/11 bombings or the death of Princess Diana. This may not be grief after all, ... Life after death?. Perhaps the most intriguing question for many people is whether or not there is life after death. A few have ... A week after death, blood-coloured blisters appear on the skin and the slightest pressure causes the top layer to slip off. ...
Some in-custody deaths are inevitable; for example, elderly inmates may die of old age. But certain types of death are highly ... Reducing Child Deaths in Nigeria. A program paid expectant mothers in Nigeria to use prenatal, delivery, and postnatal health ... Deaths involving fentanyl and other synthetic opioids have surged from around 3,000 in 2013 to more than 30,000 in 2018. ... This led to a substantial decrease in child deaths. Scaling this program up across Nigeria could reduce stillbirths by 85,000 ...
http://www.mediafire.com/file/9hz9ywx38u8bhn2/remember-death-1.mcworld/file. .header { position: absolute; width: 230px; height ...
Brain death implies the permanent absence of cerebral and brainstem functions. criteria for dx clinically confirmatory dx ... Brain death presentation * 1. Brain death 24 May 2016 brain death * 2. Brain Death Out line  What is brain death?  Causes of ... Causes: Brain Death 24 May 2016 brain death Normal Cerebral Anoxia * 11. Causes: Brain Death 24 May 2016 brain death Normal ... Causes: Brain Death 24 May 2016 brain death Normal Cerebral Trauma * 13. Brain Death : Mechanism 24 May 2016 brain death ...
The Impact of the Death Penalty The Death Penalty Kills the Innocent:. Since 1973, 138 death-row prisoners have been released ... The Death Penalty Cost More than Life in Prison: Prosecuting a death penalty case is extremely expensive for a state and drains ... The Death Penalty is Unfair: The death penalty has never been applied fairly across race, class, and gender lines. Who is ... Death Penalty Disproportionate for Rape Coker v. Georgia (1977): The Supreme Court ruled that the use of the death penalty in ...
The Black Death was a devastating global epidemic of bubonic plague that struck Europe and Asia in the mid-1300s. The plague ... Black Death is created, allegedly. According to scholars at the University of Paris, the Black Death is created on this day in ... Black Death Begins Even before the "death ships" pulled into port at Messina, many Europeans had heard rumors about a "Great ... Understanding the Black Death Today, scientists understand that the Black Death, now known as the plague, is spread by a ...
A Quandary For the Supreme Court In Death Penalty Case. The US Supreme Court is hearing arguments in Baze v. Rees ( href="http ... Ed writes, "Alabama is the only state in the nation that allows judges to overrule juries on death penalty decisions." In other ... I understand that Im probably in the minority in this country in my opposition to the death penalty. My fellow Americans ...
Even when we have video of a death threat there are those who try to deny that scientists have been threatened. Like, oh, The ... What The Australian did in several stories was pretend that a lack of death threats in emails over just six months at the ANU ... Media Watch reports on media coverage of death threats on climate scientists: One news outlet comes out of it, in our opinion, ... "I was confronted with a death threat when I gave my public lecture," Professor Schellnhuber said. "Somebody got to his feet and ...
  • The paper goes on to report that since the Supreme Court reinstated the death penalty in 1976, nationwide eight whites have been executed for killing blacks while 123 blacks have been put to death for killing whites. (slate.com)
  • Three countries have signed treaties to abolish the death penalty, but not have not yet ratified them: Angola, Madagascar, Sao Tome and Principe. (infoplease.com)
  • The Protocol to the American Convention on Human Rights to Abolish the Death Penalty. (amnesty.org)
  • Jesuit priest and former prison chaplain Father Peter Norden said Australia had a responsibility to pressure other countries to abolish the death penalty. (smh.com.au)
  • Additionally, a bill to abolish the death penalty passed the legislature in 2009, but was vetoed by former Governor Jodie Rell. (ncsl.org)
  • Amnesty International recorded at least 1,477 death sentences in 54 countries in 2020, a decrease of 36% from the total of 2,307 reported in 2019. (amnesty.org)
  • At least 28,567 people were known to be under sentence of death globally at the end of 2020. (amnesty.org)
  • Fresh off of their recent Grammy nomination for Best Metal Album of the Year (Humanicide, 2019), Thrash Metal giants DEATH ANGEL descend to unveil their Autumn 2020 EP: Under Pressure. (spotify.com)
  • The Second Optional Protocol to the International Covenant on Civil and Political Rights, aiming at the abolition of the death penalty. (amnesty.org)
  • Protocol No. 6 to the European Convention on Human Rights, concerning the abolition of the death penalty, and Protocol No. 13 to the European Convention on Human Rights, concerning the abolition of the death penalty in all circumstances. (amnesty.org)
  • China's top legislature is considering the abolition of the death penalty for a range of non-violent economic crimes. (cnbc.com)
  • China's top legislature said on Monday it was considering the abolition of the death penalty for a range of non-violent economic crimes, including animal smuggling, tax evasion and forgery. (cnbc.com)
  • The ruling blocks the state from proceeding with the executions of the 11 men who remained on death row after the abolition of the death penalty. (ncsl.org)
  • Death is the permanent, irreversible cessation of all biological functions that sustain a living organism. (wikipedia.org)
  • clarification needed] More specifically, death occurs when a living entity experiences irreversible cessation of all functioning. (wikipedia.org)
  • As it pertains to human life, death is an irreversible process where someone loses their existence as a person. (wikipedia.org)
  • Thus, the arguments for and against the DCDD boil down to a matter of defining the actual words "permanent" and "irreversible," which further complicates the challenge of defining death. (wikipedia.org)
  • As diagnostic technologies have advanced, declaring total and irreversible brain death has become ever more problematic. (newscientist.com)
  • Brain death , State of irreversible destruction of the brain . (britannica.com)
  • A record cannot be identified as available prior to purchase because under State statute (IC 16-37-1-11 and IC 37-1-11.5), the fee associated with a death certificate is for the ISDH Vital Records office to search the records to determine if a record is on file. (in.gov)
  • Following their 2017 debut, Standing at the Edge of the World, and follow-up single "Echoes," Death Bells left their hometown of Sydney for the United States. (spotify.com)
  • A cohort of 1981 women not accompanied by dependent children who used homeless shelters in Toronto in 1995 was observed for death over a mean of 2.6 years. (cmaj.ca)
  • This is a significant decrease from 20 years ago in 1995, when there were executions in 42 countries, highlighting the clear global trend of states moving away from the death penalty. (infoplease.com)
  • Nationwide, a study by Columbia University School of Law Professor James Liebman found that 68 percent of death penalty appeals were successful between 1973 and 1995. (law.com)
  • Nel 1995 anche il Live After Death , come tutti gli altri album pubblicati dagli Iron Maiden fino a quel momento, venne ripubblicato in versione doppio CD con le b-side dei singoli inseriti nel secondo CD (per la precisione i brani Losfer Words (Big 'Orra) , Sanctuary e Murders in the Rue Morgue ). (wikipedia.org)
  • CDC estimates that the burden of illness during the 2018-2019 season included an estimated 35.5 million people getting sick with influenza, 16.5 million people going to a health care provider for their illness, 490,600 hospitalizations, and 34,200 deaths from influenza ( Table 1 ). (cdc.gov)
  • By combining data on hospitalization rates, influenza testing practices, and the frequency of death in and out of the hospital from death certificates, we estimate that there were approximately 480 deaths associated with influenza in children during 2018-2019. (cdc.gov)
  • CDC estimates that influenza was associated with more than 35.5 million illnesses, more than 16.5 million medical visits, 490,600 hospitalizations, and 34,200 deaths during the 2018-2019 influenza season. (cdc.gov)
  • Some people call SIDS "crib death" because many babies who die of SIDS are found in their cribs. (medlineplus.gov)
  • Most SIDS deaths are associated with sleep, which is why it's sometimes still called "crib death. (kidshealth.org)
  • sudden infant death syndrome (SIDS) or crib death, sudden, unexpected, and unexplained death of an apparently healthy infant under one year of age (usually between two weeks and eight months old). (infoplease.com)
  • He cites the often-criticized case of Calvin Burdine, convicted and sentenced to death in Harris County for a 1983 robbery and murder. (law.com)
  • We report mortality rates and causes of death in a cohort of women who used homeless shelters in Toronto. (cmaj.ca)
  • Mortality is the number of deaths for a given area during a given period. (europa.eu)
  • The mortality rate or death rate is the mortality expressed as a proportion of the population. (europa.eu)
  • Such determination, therefore, requires drawing precise conceptual boundaries between life and death. (wikipedia.org)
  • NPR coverage of Erasing Death: The Science That Is Rewriting the Boundaries Between Life and Death by Sam, M.D., Ph.D. Parnia and Josh Young. (npr.org)
  • Meanwhile, this sudden wave of criminal deaths draws the attention of the authorities. (angelfire.com)
  • Sudden infant death syndrome (SIDS) is the sudden, unexplained death of an infant younger than one year old. (medlineplus.gov)
  • Sudden infant death syndrome (SIDS) is the sudden and unexplained death of a baby younger than 1 year old. (kidshealth.org)
  • Furman v. Georgia (1972): The Supreme Court declared the death penalty unconstitutional, as cruel and unusual punishment in violation of the Eight Amendment, and finding that the administration of the ultimate punishment was arbitrary and capricious. (aclu.org)
  • The reformers in recent years also persuaded the authorities to require Supreme Court approval for all death sentences and to make torture inadmissible in capital cases. (cnbc.com)
  • The Connecticut Supreme Court held in a 4-3 decision issued Aug. 13, that the execution of inmates who committed capital felonies before the state abolished the death penalty in 2012 would violate Connecticut's constitutional prohibition against cruel and unusual punishment. (ncsl.org)
  • Well, before long Ryuk informs Light that a shinigami can see a person's true name and remaining life span when they look at them, and a shinigami could give this power ("shinigami eyes") to a human possessing a Death Note, in exchange for half that person's own remaining life span. (angelfire.com)
  • But Bill Vance, Democratic candidate for the Texas Court of Criminal Appeals - who says he favors the death penalty for those who deserve it - contends the appeals system for death row inmates isn't working properly and says appellants aren't getting a fair shake. (law.com)
  • The country last executed prisoners exactly a year earlier, when the conservative Liberal Democratic Party still ruled the country, putting to death three inmates including one Chinese national, also for multiple murder. (smh.com.au)
  • The law was not applied retroactively, which meant that the 11 inmates were left on death row. (ncsl.org)
  • In 2009, the number of new death sentences was 112 [2] , the lowest level in 30 years. (aclu.org)
  • Japan's justice minister, a foe of capital punishment, has announced a review of the death penalty after witnessing the first executions since her centre-left government took power in 2009. (smh.com.au)
  • Death records in the ISDH Vital Records office begin with 1900. (in.gov)
  • Prior to 1900, records of death are filed only with the local health department in the county where the death actually occurred. (in.gov)
  • For deaths occurring from 1900 to 1917, the city and/or county of death is required in order to locate the record. (in.gov)
  • Deaths from opioids have been rising sharply for years , and drug overdoses already kill more Americans under age 50 than anything else. (statnews.com)
  • Deaths involving fentanyl and other synthetic opioids have surged from around 3,000 in 2013 to more than 30,000 in 2018. (rand.org)
  • For U.S. Citizens who died abroad, please visit the U.S. Department of State's Death Abroad webpage. (in.gov)
  • Maryland State's Attorney Marilyn Mosby announces charges against Baltimore police officers in connection with the death of Freddie Gray, in Baltimore, May 1, 2015. (voanews.com)
  • On April 25, 2012, Connecticut Governor Dannel Malloy signed Senate Bill 280 (2012) , ending the state's death penalty. (ncsl.org)
  • SIDS accounts for 10% of infant deaths and is the second highest cause of death (after accidents) in infancy. (infoplease.com)
  • USAT leads with a Jasper, Texas jury's quick death sentence for John William King, which the WP puts on page 3, while the LAT runs it on page 28. (slate.com)
  • The Court of Criminal Appeals found no error in the death sentence, a ruling death penalty critics rail against. (law.com)
  • The use of the death penalty for crimes committed by people younger than 18 is prohibited under international human rights law, yet some countries still sentence to death and execute juvenile defendants. (amnesty.org)
  • Death Sentence is also a manifesto, the first shots, Watson hopes, in a campaign everyone can join to bring the language back to life. (theage.com.au)
  • But Death Sentence is a polemic, not a strategy report inclusive of all stakeholders. (theage.com.au)
  • CDAS is an internationally recognised research centre focusing on the interdisciplinary social aspects of death, dying and bereavement. (bath.ac.uk)
  • During 2021 CDAS is running a series of events, talking to experts about death, dying and bereavement. (bath.ac.uk)
  • The Centre for Death & Society provides a forum for our community of researchers and practitioners to share their expertise in death, dying and bereavement. (bath.ac.uk)
  • View events relating to death, dying and bereavement held by Centre for Death & Society and other organisations. (bath.ac.uk)
  • The second concept, "partial deaths versus total extinction" stresses the belief that by experiencing the bereavement following the deaths of friends and relatives, a person is brought as close as possible to realizing "partial death. (britannica.com)
  • Thanatology also examines attitudes toward death, the meaning and behaviours of bereavement and grief, and the moral and ethical questions of euthanasia , organ transplants, and life support. (britannica.com)
  • Authorities amended Wood's death certificate on Aug. 1, 2012 to reflect some of the lingering questions about how the actress died in the waters off Catalina Island in November 1981. (yahoo.com)
  • Napalm Death - angielska grupa muzyczna powstała w 1981 roku w Meriden w pobliżu Coventry . (wikipedia.org)
  • Since 1973, 138 death-row prisoners have been released because they were innocent. (aclu.org)
  • Since 1973, for example, more than 184 prisoners sent to death row in the USA have later been exonerated or released from death row on grounds of innocence. (amnesty.org)
  • Japan has often been criticised internationally for its use of the death penalty and the fact that death row prisoners and their families are not told about the execution date in advance. (smh.com.au)
  • These statistics are most often reported as the numbers of new cases of invasive cancer and cancer deaths per year per 100,000 persons in the U.S. population. (cancer.gov)
  • When the statistics focus on cancer incidence and death in a single gender for example, on female breast cancer or male prostate cancer the numbers are per 100,000 persons of that gender. (cancer.gov)
  • The combat-related death gratuity of $100,000 took effect May 11 when the president signed the Emergency Supplemental Wartime Appropriations Act (Public Law 109-13). (military.com)
  • Because the wartime supplemental bill expires on Sept. 30, provisions to make permanent the combat-related death gratuity of $100,000 and SGLI coverage of $400,000 are included in fiscal 2006 defense authorization bills moving through Congress. (military.com)
  • There is still a lot to be done and more content to be added, and during this next phase we will continue relying on our players' invaluable feedback to help steer us in the right direction and continuously evaluate what will make In Death the best it can possibly be. (steampowered.com)
  • Determining when death has occurred is difficult, as cessation of life functions is often not simultaneous across organ systems. (wikipedia.org)
  • Other definitions for death focus on the character of cessation of something. (wikipedia.org)
  • Death was once defined as the cessation of heartbeat (cardiac arrest) and of breathing, but the development of CPR and prompt defibrillation have rendered that definition inadequate because breathing and heartbeat can sometimes be restarted. (wikipedia.org)
  • Numerous polls repeatedly show that Texans favor the death penalty, even though they fear that innocent people may be put to death. (law.com)
  • However, with the mounting of casualty sensitivity, the state gradually restructured what Levy calls its "death hierarchy" to favor privileged soldiers over soldiers drawn from lower classes and civilians, and later to place enemy civilians at the bottom of the hierarchy by the use of heavy firepower. (jhu.edu)
  • Three days after Safra's death, Daniel Serdet, the attorney general and chief prosecutor of Monaco, announced that a male nurse named Ted Maher, from Stormville, New York, had confessed to setting the blaze that killed his employer in order to win favor with the banker. (vanityfair.com)
  • Thanatology , the description or study of death and dying and the psychological mechanisms of dealing with them. (britannica.com)
  • Thanatology is concerned with the notion of death as popularly perceived and especially with the reactions of the dying, from whom it is felt much can be learned about dealing with death's approach. (britannica.com)
  • Thanatology (from Greek thanatos, "death") as a professional discipline gathered momentum following the publication of several subject-related books including The Meaning of Death (1959), edited by Herman Feifel, and The Psychology of Death (1972) by Robert Kastenbaum and Ruth Aisenberg. (britannica.com)
  • Over 18,000 lives could be saved each year if US crash deaths equaled the average rate of 19 other high-income countries. (cdc.gov)
  • We're planning to keep Death Trash in Early Access for about a year. (steampowered.com)
  • Russian oligarch Boris Berezovsky was not killed by chemical or radioactive material, British police said today, but still calling the 67-year-old's death unexplained. (yahoo.com)
  • A year after Litvinenko's death, Berezovsky said Scotland Yard had warned him about a plot on his life , but British police never confirmed his claim. (yahoo.com)
  • SIDS is the leading cause of death in children between one month and one year old. (medlineplus.gov)
  • SIDS is the leading cause of death among infants 1 month to 1 year old, and remains unpredictable despite years of research. (kidshealth.org)
  • Six Baltimore police officers were arrested and posted bail Friday, after the chief prosecutor for the eastern U.S. city of Baltimore announced criminal charges in the death of a 25-year-old man earlier this month. (voanews.com)
  • The official explanation for the death of multibillionaire banker Edmond Safra, who was asphyxiated a year ago in a locked bathroom of his Monte Carlo penthouse, is that one of Safra's nurses set the fire in order to heroically rescue his employer. (vanityfair.com)
  • Tracking the nation's progress in reducing crash injuries and deaths. (cdc.gov)
  • Ian Pannell is in Mexico City, where crematoriums and funeral homes are at capacity as the nation's COVID-19 infections and deaths soar. (yahoo.com)
  • Reducing motor vehicle crash deaths was one of the great public health achievements of the 20th century for the US. (cdc.gov)
  • Lower death rates in other high-income countries and a high percentage of risk factors in the US suggest that we can make more progress in reducing crash deaths. (cdc.gov)
  • Brain death is sometimes used as a legal definition of death. (wikipedia.org)
  • Additionally, the advent of life-sustaining therapy and the numerous criteria for defining death from both a medical and legal standpoint, have made it difficult to create a single unifying definition. (wikipedia.org)
  • This type of death where circulatory and respiratory arrest happens is known as the circulatory definition of death (DCDD). (wikipedia.org)
  • this definition therefore excludes foetal deaths ( stillbirths ). (europa.eu)
  • But foolproof it is not , and the fact that several hundred neurologists and philosophers are gathering next May for the fifth International Symposium on the Definition of Death shows this only too well. (newscientist.com)
  • Some bioethicists have even proposed that individuals should choose their own definition of death. (newscientist.com)
  • Defendants who kill white people are far more likely to get the death penalty than those who kill black people. (aclu.org)
  • As Election Day nears, a nationwide report on appellate review procedures for capital murder defendants roundly criticizes the death penalty appeals process in Texas, calling it a dysfunctional assembly line. (law.com)
  • Also, the papers don't mention it, but this story should give pause to anyone who thinks the death penalty is a deterrent. (slate.com)
  • Parnia thinks of these experiences as actual-death experiences as opposed to near-death experiences. (npr.org)
  • Chatterbox thinks the death of the just-folks obit has the potential to become a significant issue for the baby boom generation. (slate.com)
  • Anyone who thinks the death penalty does not affect Australians need only look next door to Bali, where three Australians are on death row, a rally has heard. (smh.com.au)
  • Larger declines were recorded in relation to deaths from ischaemic heart disease, where death rates fell by 30.3 % for men and 34.3 % for women, while even greater reductions were recorded for deaths from transport accidents where rates fell by 43.3 % for men and 44.3 % for women. (europa.eu)
  • This review helps tell true SIDS deaths from those due to accidents, abuse, and previously undiagnosed conditions, such as cardiac or metabolic disorders. (kidshealth.org)
  • Most SIDS deaths occur when babies are between one month and four months old. (medlineplus.gov)
  • Most SIDS deaths happen in babies 2 to 4 months old, and cases rise during cold weather. (kidshealth.org)
  • US crash deaths fell 31% compared to an average 56% in 19 other high-income countries * from 2000-2013. (cdc.gov)
  • Media Watch reports on media coverage of death threats on climate scientists: One news outlet comes out of it, in our opinion, almost unscathed: Fairfax Media's The Canberra Times. (scienceblogs.com)
  • Learn about our members, events, partners and keep up to date with Centre for Death & Society news. (bath.ac.uk)
  • This doesn't come up at big-city newspapers, because there's no way to run news stories about more than a tiny proportion of the local deaths. (slate.com)
  • One classified ad director argued to Chatterbox that the switch from news obits to paid death notices levelled the playing field between people perceived to be newsworthy and people who were not. (slate.com)
  • But that argument would have been more compelling had the trend toward paid death notices occurred spontaneously, as opposed to being forced on consumers by the shrinking news obit hole. (slate.com)
  • Reports of mass graves, torched casinos, and mutilated bodies have become so commonplace that there are days when the Google Mexico news feed is nothing but a death scroll. (prospect.org)
  • News of Berezovsky's death sparked speculation that he might have been killed like ex-KGB agent Alexander Litvinenko, who died in 2006 after he was poisoned with polonium-210 while drinking tea at a London meeting. (yahoo.com)
  • For the latest on Whitney Houston's death, see our music news page. (telegraph.co.uk)
  • For example, African Americans/Blacks, Asian Americans, Hispanic/Latinos, American Indians, Alaska Natives, and underserved Whites are more likely than the general population to have higher incidence and death statistics for certain types of cancer. (cancer.gov)
  • Although cancer deaths have declined for both Whites and African Americans/Blacks living in the United States, African Americans/Blacks continue to suffer the greatest burden for each of the most common types of cancer. (cancer.gov)
  • I suppose you could argue that they are really anti -death cults, what with endless speculation about afterlives and such, but the obsession with the end of life is still there. (umich.edu)
  • Police today said any speculation about Berezovsky's death would be premature. (yahoo.com)
  • Older adults also accounted for 75% of influenza-associated deaths, highlighting that older adults are particularly vulnerable to severe outcomes resulting from an influenza virus infection. (cdc.gov)
  • In studies from a total of 7 cities, the risk of death among homeless women was greater than that among women in the general population by a factor of 4.6 to 31.2 in the younger age group and 1.0 to 2.0 in the older age group. (cmaj.ca)
  • A collection of information and resources to do with the effects of Covid-19 on death and society. (bath.ac.uk)
  • Death Tunnel is a 2005 horror movie filmed at the Waverly Hills Sanatorium. (wikipedia.org)
  • Deep under the hospital is the 'Death Tunnel' which once were used to secretly remove the dead from the grounds. (imdb.com)
  • Death Tunnel was more than disappointing. (imdb.com)
  • I do not have the habit to walk out the theater unless the movie finishes, but with Death Tunnel there were plenty of times where I thought about it. (imdb.com)
  • Death Tunnel is really a Death Tunnel. (imdb.com)
  • By what name was Death Tunnel (2005) officially released in Canada in English? (imdb.com)
  • As the Gaza offensive of 2009 demonstrates, this new death hierarchy has opened Israel to global criticism. (jhu.edu)
  • Prosecuting a death penalty case is extremely expensive for a state and drains money that could be used for education and social programs. (aclu.org)
  • For the past several years, CDC has estimated the numbers of influenza illnesses, medical visits, hospitalizations, and deaths 1-4 . (cdc.gov)
  • An estimated 8,100 deaths occurred among working age adults (aged 18-64 years), an age group that often has low influenza vaccination uptake 11 . (cdc.gov)
  • According to current geological consensus, at various times during the middle of the Pleistocene era, which ended roughly 10,000-12,000 years ago, an inland lake, Lake Manly , formed in Death Valley. (wikipedia.org)
  • The sanction of death for the punishment of a murder in the United States has declined in recent years. (aclu.org)
  • Sicilian authorities hastily ordered the fleet of "death ships" out of the harbor, but it was too late: Over the next five years, the Black Death would kill more than 20 million people in Europe - almost one-third of the continent's population. (history.com)
  • Death Trash has already been in development for more than five years by a single developer. (steampowered.com)
  • Some countries execute people who were under 18 years old when the crime was committed, others use the death penalty against people with mental and intellectual disabilities and several others apply the death penalty after unfair trials - in clear violation of international law and standards. (amnesty.org)
  • People can spend years on death row, not knowing when their time is up, or whether they will see their families one last time. (amnesty.org)
  • A German actor who weighs 121 kilograms was jailed for 15 years on Wednesday for squashing his accountant to death. (theage.com.au)
  • All of these developments converged to spark the young Floridian's excitement, and the soon-to-be rechristened Death spent the next few years refining their chops through endless, arduous rehearsals and sporadic live performances. (apple.com)
  • Possessed's proto-death classic Seven Churches may have predated it by almost two years, but the fact of the matter is that both were concurrent works from a demo perspective, and Scream Bloody Gore merely arrived later. (apple.com)
  • Pope John Paul was 84 years old at the time of his death. (ewtn.com)
  • In the newly published study, high levels of the stress hormone cortisol in the urine were associated with a dramatic increase in death from cardiovascular disease years later. (webmd.com)
  • Chinese legal experts said in practice the death penalty has seldom been used in recent years to punish people who committed these crimes and the draft amendment was largely intended to reflect the current reality. (cnbc.com)
  • Just as he is about to light the new candle, Death lifts his scythe and the boy's candle goes out. (wikipedia.org)
  • Amid the death penalty debate - much of it centered on Gov. George W. Bush's run for president - there are increasing complaints about the appeals process for those who are sentenced to die in Texas. (law.com)
  • A close look at cancer incidence and death statistics reveals that certain groups in this country suffer disproportionately from cancer and its associated effects, including premature death. (cancer.gov)
  • For other uses, see Death Valley (disambiguation) . (wikipedia.org)
  • Players will be able to tell us any kind of feedback and ideas through the Steam Forums, the official Death Trash Discord, Twitter, and Facebook. (steampowered.com)
  • 2011 Archaeologists have retrieved examples of bones from the Black Death period and have extracted the DNA of Bubonic Plague bacteria. (angelfire.com)
  • The Black Death was a devastating global epidemic of bubonic plague that struck Europe and Asia in the mid-1300s. (history.com)
  • The second episode shows a meeting of the ICPO (International Criminal Police Organization) discussing the recent deaths of criminals, wondering if it was murder and if so how it could have been accomplished. (angelfire.com)
  • We are acutely aware of the level of interest into his death and are focused on conducting a thorough investigation as we would with any unexplained death. (yahoo.com)
  • The group called on the National Transitional Council (NTC), Libya's new leadership, to conduct an 'immediate and transparent' investigation into the deaths in Sirte. (rferl.org)
  • The category of "brain death" is seen as problematic by some scholars. (wikipedia.org)