AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
NarcolepsyCataplexyHypersomnolence, IdiopathicHLA-DQ beta-ChainsNeuropeptidesSleep ParalysisSodium OxybateDisorders of Excessive SomnolenceSleep, REMOrexin ReceptorsSleep StagesPolysomnographyIntracellular Signaling Peptides and ProteinsWakefulnessHLA-DQ AntigensReceptors, NeuropeptideBenzhydryl CompoundsSleepAdjuvants, AnesthesiaCentral Nervous System StimulantsHypothalamusREM Sleep Behavior DisorderSleep Disorders, Circadian RhythmSleep DisordersArousalNocturnal Myoclonus SyndromeParalysisInternetMethylphenidateDextroamphetamineHallucinationsCopyrightNeurologyCommunicationHippocratic OathComputer SecurityExercise TestMuscle TonusDiagnostic and Statistical Manual of Mental DisordersMuscle HypertoniaJawWaste WaterHerbal MedicinePlant PreparationsSleep Apnea, ObstructivePhysical ExaminationSleep Apnea SyndromesHypothalamic Area, LateralEnergy MetabolismCase-Control StudiesIritisTreatment OutcomeConjunctivitisOphthalmic SolutionsPupilEyeSpasm
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)Cataplexy: A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)Hypersomnolence, Idiopathic: A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)HLA-DQ beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.Neuropeptides: Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.Sleep Paralysis: A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)Sodium Oxybate: The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)Sleep, REM: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.Orexin Receptors: G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.Sleep Stages: Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.Polysomnography: Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.Intracellular Signaling Peptides and Proteins: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.Wakefulness: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.HLA-DQ Antigens: A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.Receptors, Neuropeptide: Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system.Benzhydryl Compounds: Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Adjuvants, Anesthesia: Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.Hypothalamus: Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.REM Sleep Behavior Disorder: A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)Sleep Disorders, Circadian Rhythm: Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Arousal: Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.Nocturnal Myoclonus Syndrome: Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)Paralysis: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Communication: The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.Hippocratic Oath: An oath, attributed to Hippocrates, that serves as an ethical guide for the medical profession.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Muscle Tonus: The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Muscle Hypertonia: Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Waste Water: Contaminated water generated as a waste product of human activity.Herbal Medicine: The study of medicines derived from botanical sources.Plant Preparations: Material prepared from plants.Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)Physical Examination: Systematic and thorough inspection of the patient for physical signs of disease or abnormality.Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.Hypothalamic Area, Lateral: Area in the hypothalamus bounded medially by the mammillothalamic tract and the anterior column of the FORNIX (BRAIN). The medial edge of the INTERNAL CAPSULE and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Iritis: Inflammation of the iris characterized by circumcorneal injection, aqueous flare, keratotic precipitates, and constricted and sluggish pupil along with discoloration of the iris.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.ConjunctivitisOphthalmic Solutions: Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.Pupil: The aperture in the iris through which light passes.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
NarcolepsyCataplexyHypersomnolence, IdiopathicHLA-DQ beta-ChainsNeuropeptidesSleep ParalysisSodium OxybateDisorders of Excessive SomnolenceSleep, REMOrexin ReceptorsSleep StagesPolysomnographyIntracellular Signaling Peptides and ProteinsWakefulnessHLA-DQ AntigensReceptors, NeuropeptideBenzhydryl CompoundsSleepAdjuvants, AnesthesiaCentral Nervous System StimulantsHypothalamusREM Sleep Behavior DisorderSleep Disorders, Circadian RhythmSleep DisordersArousalNocturnal Myoclonus SyndromeParalysisInternetMethylphenidateDextroamphetamineHallucinationsCopyrightNeurologyCommunicationHippocratic OathComputer SecurityExercise TestMuscle TonusDiagnostic and Statistical Manual of Mental DisordersMuscle HypertoniaJawWaste WaterHerbal MedicinePlant PreparationsSleep Apnea, ObstructivePhysical ExaminationSleep Apnea SyndromesHypothalamic Area, LateralEnergy MetabolismCase-Control StudiesIritisTreatment OutcomeConjunctivitisOphthalmic SolutionsPupilEyeSpasm
Ventrolateral preoptic nucleusVentrolateral preoptic nucleus
Narcolepsy type I is due to a decrease in orexin. It is hypothesised in narcolepsy the reduced level of orexin means that the ... the characteristic symptom of narcoleptics. In 2013 a novel method of deep brain stimulation, the magnetic field projector, ... particularly insomnia and narcolepsy - is a growing area of neuroscience research. Approximately 80% of neurons in the VLPO are ... and indicates the potential of anaesthetics in the treatment of insomnia and narcolepsy. Propofol has been shown to increase ...
Brain damageBrain damage
Narcolepsy and sleep disorders are common misdiagnoses.[citation needed] Cognitive symptoms include confusion, aggressive, ... Symptoms of brain injuries vary based on the severity of the injury or how much of the brain is affected. The three categories ... Symptoms of brain injuries can also be influenced by the location of the injury and as a result impairments are specific to the ... The symptoms of Wernicke's aphasia are caused by damage to the posterior section of the superior temporal gyrus. Damage to the ...
Head injuryHead injury
Symptoms in children[edit]. Symptoms observed in children include changes in eating habits, persistent irritability or sadness ... Narcolepsy and sleep disorders are common misdiagnoses.[citation needed] Moderate/severe brain injuries[edit]. Cognitive ... Location of brain damage predicts symptoms[edit]. Symptoms of brain injuries can also be influenced by the location of the ... Symptoms of skull fracture can include: *leaking cerebrospinal fluid (a clear fluid drainage from nose, mouth or ear) may be ...
MedicationMedication
Ritalin was first marketed in 1955 for narcolepsy; its potential users were middle-aged and the elderly. It wasn't until some ... Doctors prescribe estrogen for their older female patients both to treat short-term menopausal symptoms and to prevent long- ... Medical use of methlyphenidate is predominately for symptoms of attention deficit/hyperactivity disorder (ADHD). Consumption of ...
Idiopathic hypersomniaIdiopathic hypersomnia
A subgroup of narcoleptics with long sleep time, comprising 18% of narcoleptics in one study, had symptoms of both narcolepsy ... Gosmany M (1998). "The influence of clinical symptoms on quality of life in patients with narcolepsy". Neurology. 50: S31-6. ... Symptom intensity often varies between weeks, months, or years, and symptoms can worsen just prior to menses in women. Many ... The 3rd edition of the ICSD labels narcolepsy caused by hypocretin deficiency as "type 1 narcolepsy," which is almost always ...
Epworth Sleepiness ScaleEpworth Sleepiness Scale
... to document improvement of symptoms. In narcolepsy, the Epworth Sleepiness Scale has both a high specificity (100%) and ... where a score of 16 and above indicates the possibility of severe sleep apnea or narcolepsy. Certain questions in the scale ... though it has also shown success in detecting narcolepsy and idiopathic hypersomnia. It is used to measure excessive daytime ...
AdderallAdderall
... is generally well-tolerated and effective in treating the symptoms of ADHD and narcolepsy. At therapeutic doses, ... alleviate the symptoms of ADHD and narcolepsy by increasing the activity of the neurotransmitters norepinephrine and dopamine ... Mild withdrawal symptoms from the discontinuation of amphetamine treatment at therapeutic doses can be avoided by tapering the ... In such cases, symptoms of amphetamine psychosis commonly include paranoid and persecutory delusions as well as auditory and ...
CataplexyCataplexy
The diagnosis of narcolepsy and cataplexy is usually made by symptom presentation. Presenting with the tetrad of symptoms ( ... People with narcolepsy will often try to avoid thoughts and situations that they know are likely to evoke strong emotions ... Cataplexy without narcolepsy is rare and the cause is unknown. The term cataplexy originates from the Greek κατά (kata, meaning ... "Narcolepsy Fact Sheet". Retrieved 2011-06-23. Bourgoin, Jean-Maxime. "Il s'endort au volant de sa voiture" (in French). Sun ...
Post-chemotherapy cognitive impairmentPost-chemotherapy cognitive impairment
Modafinil, approved for narcolepsy, has been used off-label in trials with people with symptoms of PCCI. Modafinil is a ... The symptoms of PCCI were recognized by researchers in the 1980s, who typically described it as mild cognitive impairment ... Deficits in visuo-spatial, visual-motor, and visual memory functions are among the symptoms seen in post-chemotherapy patients ... While estrogen hormone supplementation may reverse the symptoms of PCCI in women treated for breast cancer, this carries health ...
Multiple complex developmental disorderMultiple complex developmental disorder
Co-occurring clusters of symptoms must also not be better explained by being symptoms of another disorder such as experiencing ... Neurological sleep disorders such as narcolepsy, insomnia, circadian rhythm disorder, etc. Conditions affecting perceptions and ... Some symptoms may include: Depression. Mania. Anxiety. Anger. Dissociative symptoms such as depersonalization, derealization, ... or cause severe symptoms. Some examples include: Learning difficulties symptoms such as dyslexia, dysgraphia, dyscalcula, NVLD ...
Sleep disorderSleep disorder
"Narcolepsy Fact Sheet". Retrieved 2011-06-23.. *^ Hockenbury, Don H. Hockenbury, Sandra E. (2010). Discovering psychology (5th ... insomnia is a symptom. It is neither a disease nor a specific condition. (from p. 322). CS1 maint: Extra text: editors list ( ... "Obstructive sleep apnea - Symptoms and causes - Mayo Clinic". www.mayoclinic.org. Retrieved 2017-11-27.. ... Certain disorders like narcolepsy, are best treated with prescription drugs such as modafinil.[13] Others, such as chronic and ...
OrexinOrexin
... these mice display many of the symptoms of narcolepsy. Researchers are using this animal model of narcolepsy to study the ... a b c Stanford Center for Narcolepsy FAQ (retrieved 27-Mar-2012) ... In humans, narcolepsy is associated with a specific variant of ... "Narcolepsy is an autoimmune disorder, Stanford researcher says". EurekAlert. American Association for the Advancement of ... The discovery that an orexin receptor mutation causes the sleep disorder canine narcolepsy[16] in Doberman Pinschers ...
HypersomniaHypersomnia
Obstructive sleep apnea "occurs frequently in narcolepsy and may delay the diagnosis of narcolepsy by several years and ... However, the associated symptoms of headaches, memory loss, and lack of concentration may be more frequent in head trauma than ... The main symptom of hypersomnia is excessive daytime sleepiness (EDS), or prolonged nighttime sleep, which has occurred for at ... Hypersomnia can also be a symptom of other sleep disorders, like sleep apnea. It may occur as an adverse effect of taking ...
Brain damageBrain damage
Signs and symptomsEdit. Symptoms of brain injuries vary based on the severity of the injury or how much of the brain is ... Narcolepsy and sleep disorders are common misdiagnoses.[citation needed]. Moderate/severe brain injuriesEdit. Cognitive ... Symptoms in childrenEdit. Symptoms observed in children include changes in eating habits, persistent irritability or sadness, ... Location of brain damage predicts symptomsEdit. Symptoms of brain injuries can also be influenced by the location of the injury ...
Parkinsons diseaseParkinson's disease
Symptoms can manifest as daytime drowsiness (including sudden sleep attacks resembling narcolepsy), disturbances in REM sleep, ... In addition to motor symptoms, PD is accompanied by a diverse range of symptoms. A number of drugs have been used to treat some ... Some of these non-motor symptoms may be present at the time of diagnosis. Four motor symptoms are considered cardinal in PD: ... Other symptoms include sensory, sleep, and emotional problems. The main motor symptoms are collectively called "parkinsonism", ...
Chronic fatigue syndrome in childrenChronic fatigue syndrome in children
However, some symptoms can be treated or managed. Treating these symptoms might provide relief for some patients with ME/CFS ... Most people with sleep disorders, like sleep apnea (brief pause in breathing during sleep) and narcolepsy (uncontrollable ... A symptom diary can be very helpful for managing ME/CFS. Keeping daily track of how patients feel and what patients do may help ... However, for children with ME/CFS, not all symptoms may go away. It is important for parents to be aware of the signs of Upper ...
ModafinilModafinil
"Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. US Modafinil in Narcolepsy ... with high negative symptom scores. Among medications demonstrated to be effective for reducing negative symptoms in combination ... In 1998, modafinil was approved by the U.S. Food and Drug Administration for the treatment of narcolepsy and in 2003 for shift ... Reported withdrawal symptoms include anhedonia, lethargy, anxiety, and insomnia. Large-scale clinical studies have found no ...
Sleep disorderSleep disorder
Narcolepsy: A chronic neurological disorder (or dyssomnia), which is caused by the brain's inability to control sleep and ... A study from the N.I.H. found that sleep is dramatically impaired by allergic symptoms and that the degree of impairment is ... Certain disorders like narcolepsy, are best treated with prescription drugs such as modafinil. Others, such as chronic and ... About 70% of those who have narcolepsy also have cataplexy, a sudden weakness in the motor muscles that can result in collapse ...
Psychoactive drugPsychoactive drug
Antipsychotics, used to treat psychotic symptoms, such as those associated with schizophrenia or severe mania, or as adjuncts ... Stimulants, used to treat disorders such as attention deficit hyperactivity disorder and narcolepsy, and for weight reduction. ... as withdrawal symptoms. Unfortunately, because clinical depression (also called major depressive disorder) is often referred to ... by which a user must use a drug to avoid physically uncomfortable or even medically harmful physical withdrawal symptoms. Drugs ...
PsychopharmacologyPsychopharmacology
Benzodiazepines are often used to reduce anxiety symptoms, muscle tension, seizure disorders, insomnia, symptoms of alcohol ... and narcolepsy, or are used recreationally. Amphetamine and methamphetamine are indirect agonists of the catecholaminergic ... Hypnotics are often used to treat the symptoms of insomnia, or other sleep disorders. Benzodiazepines are still among the most ... Antidepressants reduce symptoms of mood disorders primarily through the regulation of norepinephrine and serotonin ( ...
Dorsal raphe nucleusDorsal raphe nucleus
Cataplexy is the symptom of narcolepsy when full awareness of the environment is maintained, but all muscle tone is lost. This ... studied the nucleus raphes dorsalis as it pertained to narcolepsy. This is logical, as the raphe nuclei have been known to play ... 2000 paper that electrical stimulation of the nucleus raphes dorsalis can partially alleviate morphine withdrawal symptoms via ...
ViloxazineViloxazine
In narcolepsy, viloxazine has been shown to suppress auxiliary symptoms such as cataplexy and also abnormal sleep-onset REM ... Mitler MM, Hajdukovic R, Erman M, Koziol JA (January 1990). "Narcolepsy". Journal of Clinical Neurophysiology. 7 (1): 93-118. ... 1986). "Viloxazine hydrochloride in narcolepsy: a preliminary report". Sleep. 9 (1 Pt 2): 275-9. PMID 3704453. ... for cataplexy and narcolepsy in 1984. It was withdrawn from markets worldwide in 2002 for business reasons. As of 2015, ...
H3 receptor antagonistH3 receptor antagonist
... and narcolepsy. Narcolepsy is a sleeping disorder which is characterised by chronic sleepiness. Cataplexy, hypnagogic ... Even if H3R antagonist don't seem to be effective against positive symptoms of SCH studies have shown that H3R antagonists may ... The histaminergic system has been described as having a role in the pathophysiology of cognitive symptoms of diseases such as ... It has been proved to be useful for maintaining waking-state in the daytime for people with narcolepsy. Side effects ...
PowerBook G4PowerBook G4
Symptoms include the PowerBook suddenly entering sleep mode, no matter what the battery level is or if it is plugged in. One ... narcoleptic powerbook cured , knit1, spin1 java: PowerBook narcolepsy issue hack AppleInsider , Apple retail preps for iPhone, ... "narcolepsy". Another cause is the trackpad area heat sensor; system logs report "Power Management received emergency overtemp ... Alu Powerbook G4 Narcolepsy Ambient light sensor-sleep issue repair Alu G4 Disassembly. ...
PandemrixPandemrix
Following thorough medical investigation these symptoms have been confirmed as being compatible with narcolepsy. Consumer ... releases/2009/may/narcolepsy.html "Flu vaccine helps unravel complex causes of narcolepsy". New Scientist. 2013-12-19. ... A total of 152 cases of narcolepsy have been found in Finland during 2009-2010, and 90% of these children had received the ... A new study by the Stanford University School of Medicine examined the incidence of narcolepsy in relation to upper airway ...
ICD-10 Chapter V: Mental and behavioural disordersICD-10 Chapter V: Mental and behavioural disorders
F68.0) Elaboration of physical symptoms for psychological reasons. *(F68.1) Intentional production or feigning of symptoms or ... Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified XIX S00-T98 Injury, poisoning and ... F23.0) Acute polymorphic psychotic disorder without symptoms of schizophrenia. *(F23.1) Acute polymorphic psychotic disorder ... F31.2) Bipolar affective disorder, current episode manic with psychotic symptoms. *(F31.3) Bipolar affective disorder, current ...
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
NarcolepsyCataplexyHypersomnolence, IdiopathicHLA-DQ beta-ChainsNeuropeptidesSleep ParalysisSodium OxybateDisorders of Excessive SomnolenceSleep, REMOrexin ReceptorsSleep StagesPolysomnographyIntracellular Signaling Peptides and ProteinsWakefulnessHLA-DQ AntigensReceptors, NeuropeptideBenzhydryl CompoundsSleepAdjuvants, AnesthesiaCentral Nervous System StimulantsHypothalamusREM Sleep Behavior DisorderSleep Disorders, Circadian RhythmSleep DisordersArousalNocturnal Myoclonus SyndromeParalysisInternetMethylphenidateDextroamphetamineHallucinationsCopyrightNeurologyCommunicationHippocratic OathComputer SecurityExercise TestMuscle TonusDiagnostic and Statistical Manual of Mental DisordersMuscle HypertoniaJawWaste WaterHerbal MedicinePlant PreparationsSleep Apnea, ObstructivePhysical ExaminationSleep Apnea SyndromesHypothalamic Area, LateralEnergy MetabolismCase-Control StudiesIritisTreatment OutcomeConjunctivitisOphthalmic SolutionsPupilEyeSpasm
Narcolepsy SymptomsNarcolepsy Symptoms
The essential features of sleepiness in narcolepsy is irresistible attacks of refreshing sleep that occur almost daily (at ... Subtypes of Narcolepsy. Updated DSM-5 (2013) coding procedures for various narcolepsy subtypes:. *347.00 *Narcolepsy without ... Narcolepsy Symptoms. By Steve Bressert, Ph.D. Last updated: 8 Sep 2018 ~ 2 min read ... Narcolepsy Symptoms. Psych Central. Retrieved on January 22, 2019, from https://psychcentral.com/disorders/narcolepsy-symptoms/ ...
psychcentral.com
Narcolepsy: Causes, Symptoms and TreatmentsNarcolepsy: Causes, Symptoms and Treatments
Narcolepsy is a chronic sleep disorder where the brain is unable to regulate the bodys sleep-wake cycles. A person may fall ... Symptoms. The hallmark symptom of narcolepsy is excessive daytime sleepiness (EDS). Additional symptoms may include cataplexy, ... "Narcolepsy: Causes, symptoms and treatments." Medical News Today. MediLexicon, Intl., 28 Sep. 2017. Web.. 23 Jan. 2019. ,https ... Symptoms typically begin between the ages of 10 and 30 years.. *Narcolepsy can be treated with medications and lifestyle ...
medicalnewstoday.com
What is narcolepsy, symptoms & causes - WebMDWhat is narcolepsy, symptoms & causes - WebMD
Learn more from WebMD about the causes, symptoms, and treatment of this sleep disorder. ... Narcolepsy is a neurological disorder that affects a persons sleep/wake cycle. ... What Are the Symptoms of Narcolepsy?. Symptoms of narcolepsy include:. * Excessive daytime sleepiness (EDS): In general, EDS ... How Is Narcolepsy Treated?. Although there is no cure for narcolepsy, the most disabling symptoms of the disorder (EDS and ...
webmd.com
3 Ways to Manage Narcolepsy Symptoms - wikiHow3 Ways to Manage Narcolepsy Symptoms - wikiHow
Narcolepsy is a neurological disorder characterized by a disruptive sleep pattern, lower quality of sleep, and excessive ... Diet can affect symptoms of narcolepsy. Eating a healthy diet, low in heavy foods, can result in symptoms improving. Keep a ... As a symptom of narcolepsy, cataplexy, has this effect on the body such medications can help. Such meds can cause some side ... Improve your sleeping habits. As there is no exact cure for narcolepsy, doctors recommend patients ease symptoms of fatigue by ...
wikihow.com
All About Narcolepsy Symptoms and More - RedorbitAll About Narcolepsy Symptoms and More - Redorbit
These are common narcolepsy symptoms. Check out this article to find out more about this neurological disorder. ... Narcolepsy Symptoms. While the first symptoms usually occur in late teens and early adulthood, they can appear at any age. They ... Youll know its time to visit the doctor if you notice any of the narcolepsy symptoms above. Keep in mind that narcolepsy is a ... Narcolepsy is often described as feeling more than just tired and may include some worrying symptoms like hallucinations. Its ...
redorbit.com
What are the sleep disturbance symptoms of narcolepsy?What are the sleep disturbance symptoms of narcolepsy?
Patients with narcolepsy may experience sleep paralysis, which is the inability to move upon awakening-or, less commonly, upon ... What are the sleep disturbance symptoms of narcolepsy?. Updated: Sep 04, 2019 ... Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet. 2009 Jun. 41(6):708-11. [Medline]. [Full ... Narcolepsy: neural mechanisms of sleepiness and cataplexy. J Neurosci. 2012 Sep 5. 32(36):12305-11. [Medline]. [Full Text]. ...
medscape.com
Narcolepsy symptoms, treatments & forums | PatientsLikeMeNarcolepsy symptoms, treatments & forums | PatientsLikeMe
Find the most comprehensive real-world symptom and treatment data on narcolepsy at PatientsLikeMe. 1321 patients with ... and Lisdexamfetamine to treat their narcolepsy and its symptoms. ... Common symptoms reported by people with narcolepsy. Common ... narcolepsy experience fatigue, anxious mood, depressed mood, pain, and excessive daytime sleepiness (somnolence) and use ... What is narcolepsy?. Narcolepsy is a condition characterized by recurrent, uncontrollable brief episodes of sleep and lapses in ...
patientslikeme.com
What is Narcolepsy? Symptoms, Treatment, Cataplexy, Causes & DrugsWhat is Narcolepsy? Symptoms, Treatment, Cataplexy, Causes & Drugs
Treatment depends upon the severity of the symptoms of narcolepsy, but usually it is treated with drugs. The causes of ... Narcolepsy is a neurological order with symptoms like cataplexy (a debilitating condition in which a person collapses after ... Narcolepsy usually begins in teenagers or young adults and affects both sexes equally. The first symptom of narcolepsy to ... "Narcolepsy and Sleep." September 2015. Pisko, J. et al. "Nightmares in narcolepsy: underinvestigated symptom?" 15.8 (2014): 967 ...
rxlist.com
Narcolepsy Causes, Symptoms, Treatment & MedicationsNarcolepsy Causes, Symptoms, Treatment & Medications
Learn about narcolepsy, a sleep disorder that causes severe daytime sleepiness. Causes include genetic predisposition and the ... These symptoms may lead coworkers to perceive them as lazy.. *Persons with narcolepsy are sometimes falsely suspected of ... Narcolepsy is typically characterized by the following four symptoms with varying frequencies:*Excessive daytime sleepiness ... Approximately half of adults with narcolepsy retrospectively report symptoms beginning in their teenage years. For most ...
emedicinehealth.com
What is Narcolepsy? The Disorder, Symptoms and Current Treatments | HubPagesWhat is Narcolepsy? The Disorder, Symptoms and Current Treatments | HubPages
In this article we discuss narcolepsy symptoms, dangers and treatment. ... What is narcolepsy? Although it disrupts sleep patterns, it is not considered a sleep disorder. ... Described as a symptom of narcolepsy, it usually involves chronic insomnia as a result of the previous two symptoms. People who ... Narcolepsy Treatment. Early treatment for narcolepsy is essential and lifelong. Genetic narcolepsy often surfaces in ...
hubpages.com
Narcolepsy - Overview Incidence Causes Symptoms Diagnosis Treatment Prognosis Prevention FAQsNarcolepsy - Overview Incidence Causes Symptoms Diagnosis Treatment Prognosis Prevention FAQs
As the symptoms of narcolepsy. usually appear during adolescence, most narcoleptic patients are diagnosed too late to prevent ... Narcolepsy Severity Scale: A reliable tool assessing symptom severity and consequences. - Published by PubMed ... Quiz on Narcolepsy. Narcolepsy is a chronic neurologic disorder that involves loss of brains ability to regulate sleep and ... Narcolepsy is a neurological sleep. disorder in which the individual has an uncontrollable desire to fall asleep. Narcolepsy ...
medindia.net
Symptoms of narcolepsySymptoms of narcolepsy
Other symptoms of narcolepsy include cataplexy, hallucinations, sleep paralysis. ... The earliest symptom of narcolepsy is daytime sleepiness. ... symptoms of narcolepsy diagnosis of narcolepsy treatment for ... Whatre the symptoms of narcolepsy? - The earliest symptom of narcolepsy is daytime sleepiness. Other symptoms of narcolepsy ... Whatre the symptoms of narcolepsy?. The earliest symptom of narcolepsy is usually daytime sleepiness, which may be extreme. ...
neurology.health-cares.net
Xconomy: Jazz Pharma Gets FDA Nod for New Drug to Treat Narcolepsy SymptomsXconomy: Jazz Pharma Gets FDA Nod for New Drug to Treat Narcolepsy Symptoms
Jazz Pharmaceuticals has received FDA approval for a narcolepsy drug that it has developed as a lower-sodium successor to its ... Jazz Pharma Gets FDA Nod for New Drug to Treat Narcolepsy Symptoms. ... Narcolepsy, a chronic sleep disorder for which there is no cure, is characterized by overwhelming daytime drowsiness and sudden ... See below.] Jazz Pharmaceuticals has received FDA approval for a narcolepsy drug that it has developed as a lower-sodium ...
xconomy.com
Could these symptoms be caused by epilepsy or narcolepsy? | Zocdoc AnswersCould these symptoms be caused by "epilepsy" or "narcolepsy"? | Zocdoc Answers
It is true that the symptoms you describe could be related to an epileptic condition or narcolepsy, and the best way to ... Could these symptoms be caused by epilepsy or narcolepsy?. Symptoms: ·Suddenly,her all movement and talking stop. ·The ... Based on the symptoms you are describing, however, it does seem as though she is suffering from narcolepsy with associated ... It is true that the symptoms you describe could be related to an epileptic condition or narcolepsy, and the best way to ...
zocdoc.com
Narcolepsy - symptoms and treatment - Southern Cross NZNarcolepsy - symptoms and treatment - Southern Cross NZ
Narcolepsy is characterised by uncontrollable and sudden daytime sleep attacks that can put the person at risk of accidental ... Narcolepsy symptoms usually develop slowly and initially may be subtle. Generally symptoms develop one at a time and do not ... Narcolepsy symptoms most commonly start appearing between 15 to 25 years of age and only rarely begins after the age of 40. It ... Narcolepsy tends to remain a life-long condition but symptoms can be managed through medications and self-help treatment. In ...
southerncross.co.nz
Pediatric Narcolepsy Symptoms Differ From Those of Adults, Review Finds | AJMCPediatric Narcolepsy Symptoms Differ From Those of Adults, Review Finds | AJMC
The clinical manifestations of symptoms experienced by children and adolescents with narcolepsy can differ from those seen in ... were ashamed of their narcolepsy symptoms and 83% perceived their symptoms as keeping them from being accepted in school and ... Because the symptoms of pediatric narcolepsy can be misinterpreted, some young patients showing signs of EDS may instead be ... Diagnosis of pediatric narcolepsy is complicated not only by these differing symptoms but also by childrens limited ability to ...
ajmc.com
Narcolepsy - Symptoms, diagnosis and treatment | BMJ Best PracticeNarcolepsy - Symptoms, diagnosis and treatment | BMJ Best Practice
The classic tetrad of narcolepsy, seen in only 10% to 15% of cases, includes excessive daytime sleepiness, cataplexy, sleep ... Narcolepsy is a chronic condition characterised by a disruption of the sleep-wake cycle and rapid eye movement (REM) sleep ... Narcolepsy is a chronic condition characterised by a disruption of the sleep-wake cycle and rapid eye movement (REM) sleep ... Narcolepsy is a chronic sleep boundary disorder that affects the control of sleep and wakefulness with rapid eye movement sleep ...
bestpractice.bmj.com
Scared of the Dark: The Narcolepsy Symptoms That Nobody Talks About | by Kayla Douglas | Invisible Illness | MediumScared of the Dark: The Narcolepsy Symptoms That Nobody Talks About | by Kayla Douglas | Invisible Illness | Medium
There is currently no cure for narcolepsy. People with narcolepsy may use medication to mitigate symptoms. They may also use ... Every person with narcolepsy has a different experience with their symptoms and they are often more subtle and invisible than ... This symptom of narcolepsy is called cataplexy.. Cataplexy is sudden muscle weakness, often triggered by emotions such as ... Would you believe me if I told you these are symptoms of narcolepsy? ...
medium.com
Narcolepsy symptoms among families | MDedge NeurologyNarcolepsy symptoms among families | MDedge Neurology
Narcolepsy symptoms among families. Take Quiz. Obstructive sleep apnea and resistant hypertension in black patients. Take Quiz ... Features of narcolepsy: Hallucinations, sleep paralysis, and OSA. Take Quiz. Features of narcolepsy: Daytime sleepiness and ... Neuropsychiatric symptoms of Parkinsons disease. Take Quiz. Factors affecting Parkinsons disease symptom progression. Take ... Suspecting COVID-19 during neurologic symptom evaluation. Take Quiz. COVID-19 neuropsychiatric symptoms and effects. Take Quiz ...
mdedge.com
Narcolepsy with cataplexy Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comNarcolepsy with cataplexy Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Narcolepsy with cataplexy information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, ... What is Narcolepsy with cataplexy? *Videos related to Narcolepsy with cataplexy *Causes of Narcolepsy with cataplexy *Symptoms ... See full list of 8 symptoms of Narcolepsy with cataplexy Treatments for Narcolepsy with cataplexy. *Treatment usually involves ... Diagnostic Tests for Narcolepsy with cataplexy *Home Testing and Narcolepsy with cataplexy *Signs of Narcolepsy with cataplexy ...
rightdiagnosis.com
6 Symptoms Of Narcolepsy Or Excessive Daytime Sleepiness6 Symptoms Of Narcolepsy Or Excessive Daytime Sleepiness
Here are the symptoms of narcolepsy and tips to lower them! ... Did you know narcolepsy affects about 1 in 3000 Americans? It ... 2 Heres a look at the symptoms of narcolepsy so that you can identify whether your daytime sleepiness is narcolepsy or just ... There is no cure for narcolepsy but your doctor might be able to prescribe medication that can control some of the symptoms of ... There is also some evidence that hypnosis can be helpful with some symptoms of narcolepsy like sleep paralysis.12 ...
curejoy.com
Snoring and Sleep Apnea; Insomnia and Narcolepsy - Sleep Apnea Symptoms | Health Watch CenterSnoring and Sleep Apnea; Insomnia and Narcolepsy - Sleep Apnea Symptoms | Health Watch Center
Narcolepsy is often confused with or misdiagnosed as insomnia.. The difference between insomnia and narcolepsy. It is mainly ... Narcolepsy is a condition typified by the urge to sleep at usual times during the day, such as when at work at school and so on ... Those with narcolepsy may have no or little control over when and where they fall asleep and there is a lot of day time ... Snoring may be one of the symptoms of sleep apnea however the former is markedly different from the latter and all snorers do ...
healthwatchcenter.com
Narcolepsy: MedlinePlus Medical EncyclopediaNarcolepsy: MedlinePlus Medical Encyclopedia
Narcolepsy is a nervous system problem that causes extreme sleepiness and attacks of daytime sleep. ... Narcolepsy symptoms usually first occur between age 15 and 30 years. Below are the most common symptoms. ... Narcolepsy can usually be controlled with treatment. Treating other underlying sleep disorders can improve narcolepsy symptoms. ... Most people with narcolepsy have daytime sleepiness and cataplexy. Not everyone has all these symptoms. Surprisingly, despite ...
medlineplus.gov
List of Narcolepsy Medications (24 Compared) - Drugs.comList of Narcolepsy Medications (24 Compared) - Drugs.com
Compare risks and benefits of common medications used for Narcolepsy. Find the most popular drugs, view ratings, user reviews, ... Learn more about Narcolepsy. IBM Watson Micromedex. *Narcolepsy. Symptoms and treatments. *Narcolepsy ... About Narcolepsy: Narcolepsy is a sleep disorder associated with uncontrollable sleepiness and frequent daytime sleeping. ... Drugs Used to Treat Narcolepsy. The following list of medications are in some way related to, or used in the treatment of this ...
drugs.com
Narcolepsy - What You Need to KnowNarcolepsy - What You Need to Know
Includes: possible causes, signs and symptoms, standard treatment options and means of care and support. ... How is narcolepsy treated?. Narcolepsy is a long-term condition. The goal of treatment is to decrease your symptoms and ... How is narcolepsy diagnosed?. Your healthcare provider will ask about your symptoms and examine you. Tell him about your sleep ... What is narcolepsy?. Narcolepsy is a sleep disorder that causes severe sleepiness and frequent sudden daytime attacks of sleep ...
drugs.com
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
NarcolepsyCataplexyHypersomnolence, IdiopathicHLA-DQ beta-ChainsNeuropeptidesSleep ParalysisSodium OxybateDisorders of Excessive SomnolenceSleep, REMOrexin ReceptorsSleep StagesPolysomnographyIntracellular Signaling Peptides and ProteinsWakefulnessHLA-DQ AntigensReceptors, NeuropeptideBenzhydryl CompoundsSleepAdjuvants, AnesthesiaCentral Nervous System StimulantsHypothalamusREM Sleep Behavior DisorderSleep Disorders, Circadian RhythmSleep DisordersArousalNocturnal Myoclonus SyndromeParalysisInternetMethylphenidateDextroamphetamineHallucinationsCopyrightNeurologyCommunicationHippocratic OathComputer SecurityExercise TestMuscle TonusDiagnostic and Statistical Manual of Mental DisordersMuscle HypertoniaJawWaste WaterHerbal MedicinePlant PreparationsSleep Apnea, ObstructivePhysical ExaminationSleep Apnea SyndromesHypothalamic Area, LateralEnergy MetabolismCase-Control StudiesIritisTreatment OutcomeConjunctivitisOphthalmic SolutionsPupilEyeSpasm
Patients with narcolepsyExcessiveParalysisDisordersHallucinationsCure for narcolepsyDaytimeDiagnosis of narcolepsyTypes of narcolepsyPerson with narcolepsyNeurological disorderTreatmentsAsleepCauses of NarcolepsyObstructive sleepChronicTreat narcolepsyAffectsOnsetSuddenRisk of narcolepsyMedicationsInsomniaTreatmentDiagnose narcolepsyOccursExact cause of narcolepsyHelp people with narcolepsyModafinilOccurOrexinAwakeIndividuals with narcolepsyCommon symptom of narcolepsyApnea and narcolepsyType 1 narcolepsySuffers from narcolepsyChildren with narcolepsySubjects with narcolepsySuffer from cataplexyNapsCause narcolepsyCataplexy symptomsReported by people with narcolepsySkipVividHuman narcolepsyDevelop narcolepsyNarcolepticEpisodesWakefulnessEpworth SleepPercent of people with narcolepsySevereMedicationBrainDisorder characterizedRemain undiagnosed and untreatedPeople think of narcolepsyEtiology
Patients with narcolepsy11
Excessive62
Paralysis34
Disorders28
Hallucinations12
Cure for narcolepsy8
Daytime20
Diagnosis of narcolepsy8
Types of narcolepsy1
Person with narcolepsy7
Neurological disorder13
Treatments7
Asleep25
Causes of Narcolepsy3
Obstructive sleep1
Chronic15
Treat narcolepsy5
Affects18
Onset16
Sudden11
Risk of narcolepsy3
  • Who is at risk of narcolepsy? (medic8.com)
  • This group was used to calculate the relative risk of narcolepsy among first-degree relatives. (sleepeval.com)
  • Today's report put the increased risk of narcolepsy with vaccination at 6 cases per 100,000 people, which amounts to a 12.7-fold greater risk than in those who had not been vaccinated. (blogspot.com)
Medications15
Insomnia6
Treatment34
Diagnose narcolepsy2
Occurs8
Exact cause of narcolepsy2
Help people with narcolepsy2
Modafinil3
  • Doctors often try modafinil (Provigil) or armodafinil (Nuvigil) first for narcolepsy. (mayoclinic.org)
  • Is there any significant difference in effectiveness and side effects between armodafinil/ Nuvigil and modafinil/ Provigil for narcolepsy/sleep apnea? (healthtap.com)
  • These therapies provide the best relief of symptoms, with Provigil (modafinil) and Xyrem (sodium oxybate) being the two most popular branded drugs. (marketresearch.com)
Occur7
Orexin3
Awake5
Individuals with narcolepsy2
Common symptom of narcolepsy3
Apnea and narcolepsy1
Type 1 narcolepsy2
Suffers from narcolepsy3
Children with narcolepsy2
  • For instance, children with narcolepsy may exhibit hyperactivity, irritability, inattention, and restlessness throughout the day, possibly in an attempt to counteract sleepiness. (ajmc.com)
  • The review also discussed the significant burden of illness (BOI) among children with narcolepsy, including the burden resulting from rapid weight gain and precocious puberty, which are both associated with the disorder. (ajmc.com)
Subjects with narcolepsy1
  • BACKGROUND: Several cross-sectional studies have suggested that subjects with narcolepsy have increased body mass index (BMI) and insulin resistance. (clinicaltrials.gov)
Suffer from cataplexy1
Naps4
Cause narcolepsy3
Cataplexy symptoms1
  • For instance, cataplexy symptoms of slurred speech, facial grimacing, and automatic behaviors (eg, scratching, touching oneself) are common in children but infrequent in adults. (ajmc.com)
Reported by people with narcolepsy1
Skip1
Vivid1
Human narcolepsy3
  • This led to the reevaluation of the physiological causes and environmental causes of human narcolepsy. (infobarrel.com)
  • Despite the experimental evidence in human narcolepsy that there may be an inherited basis for at least some forms of narcolepsy, the mode of inheritance remains unknown. (wikidoc.org)
  • Human narcolepsy is not linked to a simple genetic mutation, as it is in Doberman pinschers, which were the subject of Siegel's study. (newscientist.com)
Develop narcolepsy4
  • To some extent narcolepsy runs in families, but genetics alone are not usually enough for a patient to develop narcolepsy. (healthcentral.com)
  • Jerry Siegel at the University of California, Los Angeles and his team gave commonly used immune system suppressants to dogs with a genetic mutation that makes them develop narcolepsy. (newscientist.com)
  • Siegel's team thinks people develop narcolepsy when, for some reason, their immune system turns on these cells. (newscientist.com)
  • It is not uncommon for 6-11 year olds to suddenly develop narcolepsy. (stanford.edu)
Narcoleptic6
Episodes4
Wakefulness3
Epworth Sleep2
Percent of people with narcolepsy2
Severe4
  • It is believed her narcolepsy was caused by a severe brain injury, the result of a beating that left her with a permanent indentation on her forehead. (hubpages.com)
  • When this gene is atypical, cells cannot commune properly, and consequently abnormal sleeping patterns develop which in the extreme become severe Narcolepsy. (sleepassociation.org)
  • It can be mild -- causing only one symptom, such as a momentarily droopy eyelid -- or, in more severe cases, a person may lose all muscle control and fully collapse. (henryford.com)
  • Furthermore, when symptoms did appear, they were also much less severe. (newscientist.com)
Medication3
Brain8
Disorder characterized1
Remain undiagnosed and untreated1
People think of narcolepsy1
  • When people think of narcolepsy, they think of the hilarious media portrayals, like the Argentinian in the movie Moulin Rouge passing out at the most inopportune moments. (medium.com)
Etiology1