Calcinosis: Pathologic deposition of calcium salts in tissues.CREST Syndrome: A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.Skin Diseases, Metabolic: Diseases of the skin associated with underlying metabolic disorders.Dermatomyositis: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)Hyperphosphatemia: A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.N-Acetylgalactosaminyltransferases: Enzymes that catalyze the transfer of N-acetylgalactosamine from a nucleoside diphosphate N-acetylgalactosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Skin DiseasesScleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Foot Diseases: Anatomical and functional disorders affecting the foot.Joint DiseasesTelangiectasis: Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.Hyperostosis, Cortical, Congenital: A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)Skin UlcerCalcium Gluconate: The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.Nadroparin: A heparin fraction with a mean molecular weight of 4500 daltons. It is isolated from porcine mucosal heparin and used as an antithrombotic agent. (From Merck Index, 11th ed)Eyelid DiseasesCalcium Pyrophosphate: An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).Nephrocalcinosis: A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.alpha-2-HS-Glycoprotein: A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.Phosphates: Inorganic salts of phosphoric acid.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Fibroblast Growth Factors: A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.GlucuronidasePhosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Centromere: The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.Osteopontin: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Cutis Laxa: A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)Glycodeoxycholic Acid: A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Lung Compliance: The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Vital Capacity: The volume of air that is exhaled by a maximal expiration following a maximal inspiration.Hyperostosis: Increase in the mass of bone per unit volume.Luciferases, Renilla: Luciferases from RENILLA that oxidizes certain LUMINESCENT AGENTS to cause emission of PHOTONS.Immunoprecipitation: The aggregation of soluble ANTIGENS with ANTIBODIES, alone or with antibody binding factors such as ANTI-ANTIBODIES or STAPHYLOCOCCAL PROTEIN A, into complexes large enough to fall out of solution.Photography: Method of making images on a sensitized surface by exposure to light or other radiant energy.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Software: Sequential operating programs and data which instruct the functioning of a digital computer.
Enzootic Calcinosis Archived 2014-07-28 at the Wayback Machine. Gruenberg MS, PhD, DECAR DECBHM. W.G., April 2014. Enzootic ... Calcinosis. The Merck Veternary Manual. Merck Sharp & Dohme, Whitehouse Station, NJ, USA. Topical Agents (Toxicity) Archived ...
TSC2 Tumoral calcinosis, familial, normophosphatemic; 610455; SAMD9 Tumoral calcinosis, hyperphosphatemic; 211900; KL Tumoral ... calcinosis, hyperphosphatemic, familial; 211900; FGF23 Tumoral calcinosis, hyperphosphatemic, familial; 211900; GALNT3 Tyrosine ...
"calcinosis_cutis_2_060122". Derm Atlas. Retrieved 13 March 2012. "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial ...
Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue. ... Calcinosis Monckeberg's arteriosclerosis "Cell Injury". Bertazzo, Sergio; Gentleman, Eileen; Cloyd, Kristy L.; Chester, Adrian ...
"Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology. 14 (3): 224-8. doi:10.1097/PAP. ... Drowsiness Headache Gastric mucosal calcinosis Heart valve calcification Hypercalcemia Increased intracranial pressure ...
Dystrophic calcinosis cutis has also been reported. Other serious sequelae include sialolithiasis of the submandibular gland ... Oga, A.; Kadowaki, T.; Hamanaka, S.; Sasaki, K. (1998). "Dystrophic calcinosis cutis in the skin below the mandible of a ...
Dereure O (May 2007). "[SAMD9 mutation in normophosphatemic familial tumoral calcinosis]". Annales De Dermatologie Et De ... "A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis". American Journal of Human Genetics. 79 ( ...
2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase ... 2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O- ... cause familial tumoral calcinosis". Nat Genet. 36 (6): 579-81. doi:10.1038/ng1358. PMID 15133511. "Entrez Gene: GALNT3 UDP-N- ... "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis". J. Hum. Genet. 52 (5): 464-8. doi ...
Calcinosis Fahr's syndrome Muscular atrophy "OMIM Entry - # 259050 - PRIMROSE SYNDROME; PRIMS". omim.org. Retrieved 6 August ...
Kalani, MY; Martirosyan, NL; Little, AS; Kakarla, UK; Theodore, N (Dec 2011). "Tumoral calcinosis presenting as a deformity of ...
Bonazza S, La Morgia C, Martinelli P, Capellari S (August 2011). "Strio-pallido-dentate calcinosis: a diagnostic approach in ... Loeb JA (March 1998). "Functional improvement in a patient with cerebral calcinosis using a bisphosphonate". Mov. Disord. 13 (2 ...
The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
"calcinosis_cutis_2_060122". Derm Atlas. Archived from the original on 5 February 2007. Retrieved 13 March 2012.. ...
Some children develop calcinosis, which are calcium deposits under the skin. The rash is the source of the "dermato-" part of ... calcinosis and neopterin. Once a diagnosis of JDMS is made, the treatment is often a 3-day course of Intravenous ("pulse") ... calcinosis, dysphonia and nailfold capillaroscopy. Other useful criteria include myositis-specific or -related antibodies, ...
Calcinosis cutis Skin lesion List of cutaneous conditions James, William D.; Berger, Timothy G.; et al. (2006). Andrews' ...
2000). Enzootic calcinosis in 16 cows from 6 dairy farms in Unterengadin. Schweiz Arch Tierheilkd. 142:6 333-8. Braun, U., et ... 2000). Enzootic calcinosis in goats caused by golden oat grass (Trisetum flavescens). Veterinary Record 146 161-2. Grabner, A ... 1985). Enzootic calcinosis in the horse. Tierarztl Prax Suppl. 1 84-93. Ess. Agrostogr. 88, 153. 1812 GrassBase entry: Trisetum ... This grass is noted for being toxic to livestock, causing calcinosis, the deposition of calcium in soft tissues including ...
... calcinosis (calcium deposits in blood vessels); atherosclerosis (blockage of blood vessels); type 2 diabetes; loss of bone mass ...
Lesions may also appear on the ear and eyelid. Calcinosis cutis Skin lesion List of cutaneous conditions ... Subepidermal calcified nodule (also known as a "solitary congenital nodular calcification", and "Winer's nodular calcinosis") ...
It is a part of CREST syndrome, referring to the five main features: calcinosis, Raynaud syndrome, esophageal dysmotility, ... and subcutaneous calcinosis: a syndrome mimicking hereditary hemorrhagic telangiectasia". Bulletin of the Johns Hopkins ...
CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynaud's phenomenon is ... The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, ... Scleroderma Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutanious calcinosis: ...
Typical clinical features include jaundice, elevated blood levels of alkaline phosphatase, calcinosis cutis, telangiectasias, ...
Other: facial pain due to trigeminal neuralgia, hand paresthesias, headache, stroke, fatigue, calcinosis and weight loss. ...
... renal insufficiency and calcinosis. Calcium forms complexes with a number of pharmaceutical drugs, reducing their ...
Excretory calcinosis in American lobsters in Long Island Sound was described in 2002. The disease causes mineralized calculi to ... A. D. M. Dove (2005). "Ultrastructural features of excretory calcinosis in the lobster, Homarus americanus Milne-Edwards". ... "Excretory calcinosis: a new fatal disease of wild American lobsters Homarus americanus". Diseases of Aquatic Organisms. 58 (2- ...
Gorospe M, Fadare O (May 2007). "Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology ...
Calcinosis is the formation of calcium deposits in any soft tissue. The most common type of calcinosis is dystrophic ... The cause of the rare condition of tumoral calcinosis is not entirely understood. It is generally characterized by large, ... Calcinosis cutis Dermatomyositis Fahrs syndrome Hypercalcemia Hyperphosphatemia Primrose syndrome Scleroderma Univ. Washington ...
Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location i.e. ... The name indicates calcinosis (calcium deposition) which resembles tumor (like a new growth). They are not true neoplasms - ... Genetests/NCBI/NIH/UW entries on Hyperphosphatemic Familial Tumoral Calcinosis. ...
... calcinosis) in the bodys tissues. Explore symptoms, inheritance, genetics of this condition. ... Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in ... Calcinosis may also develop in the soft tissue of the feet, legs, and hands. Rarely, calcinosis occurs in blood vessels or in ... Genetic Testing Registry: Hyperphosphatemic familial tumoral calcinosis 3 *Genetic Testing Registry: TUMORAL CALCINOSIS, ...
Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat ... Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. ... Idiopathic calcinosis cutis: Idiopathic calcinosis cutis is the occurrence of calcinosis cutis without any underlying tissue ... Iatrogenic calcinosis cutis: Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of ...
... By Stephanie Eschenbach, MD and Thomas L. Pope, Jr., MD, FACR ... 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas ... subcutaneous calcinosis on the left thumb volar pad; 5) moderate-to-severe resorption of the right first-, second-, and third- ... "7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma.6 ...
We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy ... Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive ... In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited ... Thus, this report describes the first case, to our knowledge, of autoimmune hyperphosphatemic tumoral calcinosis with ...
Evaluation of Calcinosis Prevalence in Systemic Sclerosis : a Cross Sectional Study Evaluating Calcinosis Cutis Prevalence by ... Evaluation of Calcinosis in Systemic Sclerosis (CALCIDERMIS). The safety and scientific validity of this study is the ... Calcinosis cutis prevalence by radiographic assessment [ Time Frame: at inclusion ( baseline) ]. Secondary Outcome Measures : * ... Calcinosis. Pathologic Processes. Connective Tissue Diseases. Skin Diseases. Calcium Metabolism Disorders. Metabolic Diseases. ...
Bilateral striopallidodentate calcinosis. Disease definition Bilateral striopallidodentate calcinosis (BSPDC, also erroneously ...
... primary hyperphosphatemic tumoral calcinosis; tumoral calcinosis with hyperphosphatemia ... Synonyms: cortical hyperostosis with hyperphosphatemia; familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic ... hyperostosis syndrome; familial Teutschlaender disease; HFTC; HHS; hypercalcemic tumoral calcinosis; hyperostosis with ... tumoral calcinosis with hyperphosphatemia Alt IDs: OMIM:211900, ICD10CM:M11.2, ORDO:306661 Definition: A calcinosis ...
V. Mehta and C. Balachandran, "Idiopathic vulvar calcinosis: the counterpart of idiopathic scrotal calcinosis," Indian Journal ... Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management. Usman M. Tela1 and M. Bashir Ibrahim2 ... S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of ... C. H. Chang, C. H. Yang, and H. S. Hong, "Surgical pearl: pinch-punch excisions for scrotal calcinosis," Journal of the ...
... calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN ... Also see Photo of Calcinosis on Fingertip). A year and a half ago, her doctor stopped her Raynauds medication for emotional ... Photo of Calcinosis on Dime. Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer ... The calcium nodule (calcinosis) is an ugly thing, with lots of irregularities to hang onto flesh. My wife has had scleroderma ...
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Calcinosis circumscripta is deposition of calcium at bony prominences or, in the footpads and mouth. It is usually a disease of ... Calcinosis cutis is induced by local skin damage in susceptible animals and takes two forms: dystrophic or metastatic. The ... How does calcinosis cutis and calcinosis circumscripta typically progress?. In the case of calcinosis circumscripta, single ... Calcinosis cutis occurs in susceptible pets in areas where local skin damage has occurred. Calcinosis cutis has two forms:. * ...
CALCINOSIS TREATED BY PARATHYROIDECTOMY1 ELMER C. BARTELS, M.D., F.A.C.P.; RICHARD B. CATTELL, M.D. ... CALCINOSIS AND SCLERODERMA WITH PARATHYROIDECTOMY1 Annals of Internal Medicine; 18 (2): 225-232 ... Subcutaneous calcinosis, a disease tending to serious bodily disability, presents a most difficult therapeutic problem. It is ... Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case ...
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share Get VisualDx Mobile. There are VisualDx ... L94.2 - Calcinosis cutis. SNOMEDCT:. 21323007 - Calcinosis cutis. Look For. Subscription Required. Diagnostic Pearls. ... Calcinosis cutis in Infant/Neonate. Print Images (7) Contributors: Noah Craft MD, PhD, Belinda Tan MD, PhD, Lowell A. Goldsmith ... Note, however, that calcinosis cutis can occur anywhere on the body. Local trauma, infections (particularly parasitic, eg, ...
... index finger on knuckle which has lead to a calcinosis, (same finger), which has become abscessed on pad, its becoming bigger. ... Not sure what hurts more the ulcer or the calcinosis! :wacko: Well..... even if I slightly bump the calcinosis, or touch it, it ... Ulcer and Calcinosis By Annie20, June 8, 2011. in Sclero Forums (MAIN) ... If I bump or press on the calcinosis, it hurts tremendously. (It has become bigger.) I do not want to subject myself to anymore ...
Pronounced Linear Calcinosis in a Boy with Mild Dermatomyositis del Carmen Boente, María; Nadra, Graciela; Asial, Raúl et al. ... Calcinosis in Ruminants due to Plant Poisoning: Contributions on the Pathogenesis Acamovic, T.; Stewart, C. S.; Pennycott, T. ... Tumoral Calcinosis and Calciphylaxis After Renal Transplantation Fernandez, E.; Torregrosa, J. V.; Zarraga, S. et al. 1998-01- ... Tumoral Calcinosis Associated With End-Stage Renal Disease: A Case Study Capes, M.; Fox, R. B.; Association of Chiropractic ...
... defined as calcinosis involving the torso or 2 extremities) and moderate to severe calcinosis (indicated by a calcinosis ... Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find ... Has moderate to severe calcinosis, defined as having a calcinosis activity visual analogue scale score of greater than or equal ... Improvement of calcinosis lesions, assessed by Calcinosis Assessment Tool, durometry measurements, photography, and imaging ...
Calcium and Phosphate Metabolism in Tumoral Calcinosis PAUL D. MITNICK, M.D.; STANLEY GOLDFARB, M.D.; EDUARDO SLATOPOLSKY, M.D ... Calcium and Phosphate Metabolism in Tumoral Calcinosis. Ann Intern Med. 1980;92:482-487. doi: 10.7326/0003-4819-92-4-482 ... We have recently seen a patient with tumoral calcinosis, a syndrome comprising hyperphosphatemia, normocalcemia, normal ...
Treating calcinosis cutis via a topical wash with DMSO every other day was effective for the symptoms of calcinosis cutis. ... A dog with calcinosis cutis was treated by topical dimethyl sulfoxide (DMSO) administration, reaching a complete involution of ... For this reason, DMSO is proposed as a topical treatment for the management of calcinosis cutis in dogs. The authors present ... Resolution of iatrogenic calcinosis cutis in a dog through topical application of DMSO. 26 Sep 2018 ...
Find out information about Calcinosis. Deposition of calcium salts in the skin, subcutaneous tissue, or other part of the body ... Related to Calcinosis: calcinosis circumscripta, Calcinosis cutis, tumoral calcinosis. calcinosis. [‚kal·sə′nō·səs] (medicine) ... Cutaneous calcinosis or Calcinosis cutis is a skin disease of dogs characterized by dystrophic calcium deposition in dermis and ... La radiografia confirmo la sospecha de extensas areas de calcinosis (Figura 1).. Calcinosis asimetrica en un adulto con ...
What is tumoral calcinosis? Meaning of tumoral calcinosis medical term. What does tumoral calcinosis mean? ... Looking for online definition of tumoral calcinosis in the Medical Dictionary? tumoral calcinosis explanation free. ... 2. calcinosis that develops in association with neoplastic conditions. tumoral calcinosis. Oncology A condition characterized ... Spontaneous regression of multiple tumoral calcinosis in a child.. Selim kalsinozis kutis/Benign calcinosis cutis ...
As expected given the plain film appearances, there are multiple low-T2 lesions anterior to the patella consistent with multifocal calcification or ossification. ...
"Calcinosis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Calcinosis" by people in this website by year, and whether " ... Below are the most recent publications written about "Calcinosis" by people in Profiles. ...
FamilialScrotalCalcificationDermatomyositisCircumscriptaMetastaticClinicalUniversalisTreatment of CalcinosisHyperphosphatemiaEtiologyDiagnosisSclerodermaSystemicTermed calcinosis cutisIatrogenic calcinosis cutisTumoral calcinosis associatedDystrophic cardiac calcinosisMawdsley Calcinosis QuestionnaireBenignAbstractCalcificationsPathogenesisUncommonSurgical excisionSodium thiosulfateNodulesDiffuseComplicationsTumoural calcinosisSubcutaneous calcinosisAutosomal recessive inheritancePatientsLesionsPatientRenalPulmonarySyndromeSoft tissueFGF23MetabolismCommonlyDeposits
- Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (medlineplus.gov)
- Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). (jci.org)
- Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23). (malacards.org)
- There are three types: familial tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
- Familial tumoral calcinosis is seen in healthy adolescent patients. (statpearls.com)
- 76 Tumoral calcinosis, normophosphatemic, familial: An uncommon, life-threatening disorder characterized by progressive deposition of calcified masses in cutaneous and subcutaneous tissues. (malacards.org)
- An important gene associated with Tumoral Calcinosis, Normophosphatemic, Familial is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network . (malacards.org)
- 77 Normophosphatemic familial tumoral calcinosis is a cutaneous disorder characterized by cutaneous. (malacards.org)
- Adams WM et al: Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation. (statdx.com)
- Slavin RE et al: Familial tumoral calcinosis. (statdx.com)
- Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) and Hyperphosphatemic Hyperostosis Syndrome (HHS) are associated with autosomal recessive mutations in three different genes, FGF23 , GALNT3 and KL , leading to reduced levels of fibroblast growth factor 23 (FGF23) and subsequent clinical effects. (biomedcentral.com)
- Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare monogenic disorder with disturbances in the hormonal regulation of phosphate levels by FGF23, leading to soft tissue calcifications [ 2 ]. (biomedcentral.com)
- At least 25 mutations in the GALNT3 gene have been found to cause hyperphosphatemic familial tumoral calcinosis (HFTC), a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (nih.gov)
- Chefetz I, Kohno K, Izumi H, Uitto J, Richard G, Sprecher E. GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. (nih.gov)
- Chefetz I, Sprecher E. Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis. (nih.gov)
- Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and αKlotho). (nih.gov)
- Clinical variability of familial tumoral calcinosis caused by novel GALNT3 mutations. (nih.gov)
- Sprecher E. Familial tumoral calcinosis: from characterization of a rare phenotype to the pathogenesis of ectopic calcification. (nih.gov)
- Histologically, lesions display collagen necrobiosis, followed by cyst formation and a foreign-body response with calcification Two forms of tumoral calcinosis have been described: normocalcemic tumoral calcinosis and familial tumoral calcinosis. (cdc.gov)
- PubMed is a searchable database of medical literature and lists journal articles that discuss Familial tumoral calcinosis. (cdc.gov)
- M. Dini and M. Colafranceschi, "Should scrotal calcinosis still be termed idiopathic? (hindawi.com)
- A. G. Saad and G. S. Zaatari, "Scrotal calcinosis: is it idiopathic? (hindawi.com)
- S. G. Browne, "Calcinosis circumscripta of the scrotal wall, the aetiologic role of onchocerca vulvulus," British Journal of Dermatology , vol. 74, pp. 136-140, 1962. (hindawi.com)
- J. M. Swinehart and L. E. Golitz, "Scrotal calcinosis. (hindawi.com)
- U. H. G. Michl, A. J. Gross, V. Loy, and K. P. Dieckmann, "Idiopathic calcinosis of the scrotum-a specific entity of the scrotal skin. (hindawi.com)
- Scrotal calcinosis has traditionally been classified as a type of idiopathic calcinosis cutis that presents as multiple, firm nodules on the scrotum. (clinicaladvisor.com)
- This association raises the question as to whether scrotal calcinosis would be more appropriately classified as a type of dystrophic calcinosis cutis. (clinicaladvisor.com)
- Idiopathic scrotal calcinosis is a rare benign disease which presents with multiple asymptomatic various sized nodules on the scrotal skin wall. (alliedacademies.org)
- It includes tumoral calcinosis, subepidermal calcified nodules, and scrotal calcinosis. (statpearls.com)
- Idiopathic calcinosis cutis of the scrotum (ICCS), also called idiopathic scrotal calcinosis, is an uncommon entity and was first described by Lewinski in 1883 [ 2 ]. (biomedcentral.com)
- In recent times, there has been a debate on the pathogenesis of scrotal calcinosis, with questions being raised on its idiopathic nature [ 3 , 4 ]. (biomedcentral.com)
- Idiopathic Scrotal Calcinosis is a skin condition that I occasionally encounter in both my The Woodlands dermatology and Conroe dermatology offices. (perridermatology.com)
- Idiopathic scrotal calcinosis is a rare scrotal benign disease . (bvsalud.org)
- Giovanni Cannarozzo ,Luigi Bennardo ,Francesca Negosanti ,Steven Paul Nisticò , CO2 laser treatment in idiopathic scrotal calcinosis: a case series, J. Lasers Med. (who.int)
- Idiopathic scrotal calcinosis (ISC) is a benign and uncommon condition characterized by the presence of multiple and calcified nodules of the scrotum without disorders in the calcium/phosphorous metabolism. (who.int)
- Ahmadnia et al discuss pathophysiology and treatment of the rare disorder, idiopathic scrotal calcinosis, and Fitouri et al report the safety and efficacy of ofloxacin on BCG-induced toxicity in patients with superficial bladder cancer. (urotoday.com)
- The most common type of calcinosis is dystrophic calcification. (wikipedia.org)
- Tumoral calcinosis may be defined as metastatic periarticular calcification that can be found in a wide variety of conditions such as primary hyperthyroidism and connective tissue diseases, as well as an idiopathic form. (thefreedictionary.com)
- Some patients with ACTD may experience calcinosis universalis with widespread calcification of the subcutaneous tissue, muscles, and tendons. (clinicaladvisor.com)
- Dystrophic calcification is the most common cause of calcinosis cutis and is associated with normal laboratory values of calcium and phosphorus. (statpearls.com)
- NFTC shows a striking resemblance to acquired dystrophic calcinosis, in which tissue calcification occurs as a consequence of tissue injury/inflammation. (malacards.org)
- Plain radiography revealed calcinosis universalis in abdomen ( Fig. 1 ), pelvis and thighs, with intramuscular calcification proximal to the distal insertion of vastus medialis ( Fig. 2 ) and generalized osteopenia. (reumatologiaclinica.org)
- Calcinosis in thighs with intramuscular calcification proximal to the distal insertion of the vastus medialis. (reumatologiaclinica.org)
- Calcinosis cutis Dermatomyositis Fahr's syndrome Hypercalcemia Hyperphosphatemia Primrose syndrome Scleroderma Univ. (wikipedia.org)
- Calcinosis, a serious complication of dermatomyositis, involves deposition of calcium (carbonate apatite) in soft tissue, and can result in negative impacts on quality of life and physical function. (centerwatch.com)
- To date, there are no known effective therapies that are approved for the treatment of dermatomyositis-associated calcinosis, and there is no consensus within the medical community on the optimum treatment strategy for this often-debilitating condition. (centerwatch.com)
- In order to gather more robust data on the utility of this medication in the treatment of calcinosis associated with adult and juvenile dermatomyositis, we propose to evaluate its effects in the context of a prospective clinical trial. (centerwatch.com)
- We plan to enroll participants at a single center into a single-arm, open-label study, with the overall objective of evaluating the efficacy and safety of intravenous sodium thiosulfate use in patients with moderate to severe extensive calcinosis associated with juvenile and adult dermatomyositis. (centerwatch.com)
- Calcinosis cutis is seen in 30% of adults and up to 70% of children and adolescents with dermatomyositis. (statpearls.com)
- People with connective tissue diseases such as systemic scleroderma , dermatomyositis and cutaneous lupus erythematosus may also develop calcinosis. (sclerodermanews.com)
- There is calcinosis cutis from prednisone a length significant prednisone therapy in akathisia grade that is modified by younger email at vanishedi and dermatomyositis strength. (auto-uitlaat.be)
- We report a 14-year-old girl with juvenile dermatomyositis (JDM) complicated by severe inflammatory calcinosis successfully treated with thalidomide. (biomedcentral.com)
- We report a 26-year-old woman with severe calcinosis associated with dermatomyositis. (elsevier.com)
- Although calcinosis of the skin or muscles is unusual in adults with dermatomyositis, this patient developed subcutaneous calcinosis with tenderness on the arms, axillary areas, shoulder areas, chest, abdomen, pelvis, and limbs. (elsevier.com)
- In addition, they are currently investigating the burden of calcinosis in adult dermatomyositis by patient self-report and then utilizing novel imaging modalities to examine the extent of calcinosis in these patients. (hopkinsmedicine.org)
- Calcinosis cutis over the left elbow in a patient with juvenile dermatomyositis for 16 years. (medscape.com)
- Calcinosis develops in an estimated 40% of patients with Juvenile Dermatomyositis (JDM). (acrabstracts.org)
- Orandi A, Dharnidharka V, Al-Hammadi N, Baszis K. Clinical Features and Frequency of Biologic use in Patients with Juvenile Dermatomyositis-associated Calcinosis [abstract]. (acrabstracts.org)
- Calcinosis circumscripta is the deposition of calcium usually at bony prominences (i.e., where bone and skin are thinly separated) or in the footpads and mouth. (vcahospitals.com)
- The cause of calcinosis circumscripta is unknown, but there seems to be a genetic or hereditary component. (vcahospitals.com)
- Pets with calcinosis circumscripta usually have a single lesion over a bony prominence or in the mouth, particularly the tongue. (vcahospitals.com)
- How does calcinosis cutis and calcinosis circumscripta typically progress? (vcahospitals.com)
- In the case of calcinosis circumscripta , single lesions due to causes such as trauma can be cured surgically. (vcahospitals.com)
- Recurrence of calcinosis circumscripta after surgery does not tend to occur. (vcahospitals.com)
- characteristic of calcinosis circumscripta. (learningradiology.com)
- The lesion was successfully excised, and histopathology was performed, revealing evidence of both multiple cartilaginous exostoses and calcinosis circumscripta. (ovid.com)
- Additionally, multiple cartilaginous exostoses have not previously been reported to occur in combination with calcinosis circumscripta. (ovid.com)
- The disorder is classified as calcinosis circumscripta if it is limited to an extremity or joint. (statpearls.com)
- Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis ( table 1 ). (uptodate.com)
- Metastatic calcinosis cutis results from abnormal calcium or phosphate metabolism, leading to the precipitation of calcium in skin and subcutaneous tissue. (uptodate.com)
- In dogs, the most common cause of metastatic calcinosis cutis is the overproduction of corticosteroids, a type of hormone produced by the adrenal glands. (vcahospitals.com)
- A less common cause of metastatic calcinosis cutis in dogs is corticosteroid ('steroid') treatment for extended periods of time (e.g., for allergies). (vcahospitals.com)
- Other, more rare, causes of metastatic calcinosis cutis include kidney disease (the most common cause in cats), diabetes mellitus, lung disease, and malignant tumors that produce abnormal hormones that increase blood calcium concentrations (including cancer of the anal glands and cancer of the lymphoid system). (vcahospitals.com)
- Calcinosis cutis is classified as dystrophic, metastatic, iatrogenic, or idiopathic based on these causative agents. (clinicaladvisor.com)
- Metastatic calcinosis cutis presents with altered calcium and phosphorus metabolism, typically in the setting of chronic renal disease. (clinicaladvisor.com)
- Metastatic calcinosis cutis may involve visceral calcifications as well as potentially generalized dermal or symmetrical periarticular distribution. (clinicaladvisor.com)
- Given the connection between metastatic calcinosis cutis and disorders of calcium and phosphorus metabolism, assessing serum calcium, phosphorus, and parathyroid hormone levels as well as a urine analysis, are crucial. (clinicaladvisor.com)
- More detailed information about the symptoms , causes , and treatments of Metastatic calcinosis cutis is available below. (rightdiagnosis.com)
- CT scan however demonstrates these calcifications in many more conditions like hamartoma (2) , chondroma (3) , carcinoid (4) , lung carcinoma (5) , metastatic calcifications following cardiac surgery in children (6) , calcinosis following liver transplant (7) , pulmonary alveolar microlithiasis (8) , Amiodarone pulmonary toxicity (9) to name a few. (ijars.net)
- In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. (jci.org)
- The authors present the clinical case of a dog with seropositive leishmaniosis and secondary immune-mediated haemolytic anaemia who was affected by intense dermatopathia on the dorsal area, diagnosed by a biopsy as calcinosis cutis. (bva.co.uk)
- We report the favorable outcome of rituximab on severe calcinosis in 4 JDM patients and present their clinical data. (scirp.org)
- A final diagnosis of calcinosis cutis was made based on histopathological and clinical findings. (oalib.com)
- Based on clinical features and laboratory reports, a diagnosis of idiopathic calcinosis cutis of the scrotum was made. (biomedcentral.com)
- Pathology department's opinion was that the mucosal calcinosis observed in the corpus mucosa could be associated with calcium dysregulation and could also be secondary to medication, and recommended analyzing correlation with clinical findings. (heighpubs.org)
- CREST ( calcinosis , Raynaud phenomenon , esophageal dysmotility , sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas , and its name is an acronym for the cardinal clinical features of the syndrome. (medscape.com)
- McGuinness FE: Hyperphosphataemic tumoral calcinosis in Bedouin Arabs--clinical and radiological features. (statdx.com)
- Noyez JF et al: Tumoral calcinosis, a clinical report of eleven cases. (statdx.com)
- Clinical experience suggests the utility of sodium thiosulfate to treat delayed calcium extravasation in patients with severely debilitating, unresolving, or limb-threatening calcinosis cutis [Reynolds . (drugs.com)
- Clinical presentation and radiographs of patient with tumoral calcinosis. (jci.org)
- 8. Noyez J, Murphree S, Chen K. Tumoral calcinosis, a clinical report of eleven cases. (jbstjournal.com)
- Conflicting studies have not definitively identified actionable risk factors or demonstrated that patients with calcinosis have unique clinical features. (acrabstracts.org)
- Using a large patient registry, we aimed to identify patients at risk for calcinosis, distinguish clinical phenotypes, and examine treatment history with biologic agents. (acrabstracts.org)
- Calcinosis universalis occurs when there is diffuse involvement of subcutaneous and fibrous structures of muscles and tendons. (statpearls.com)
- Calcinosis universalis in abdomen and pelvis. (reumatologiaclinica.org)
- Please cite this article as: Novella Navarro M, Muñoz Gómez MM, Salvatierra Ossorio J. Calcinosis universalis en paciente con dermatomiositis. (reumatologiaclinica.org)
- Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10. (thefreedictionary.com)
- Conclusion: Our study showed the favorable effect of rituximab in treatment of calcinosis in 4 patients with JDM-associated severe calcinosis when it was used with other conventional DMARDs. (scirp.org)
- Diagnosis and follow up of calcinosis was clinically and by X-ray. (scirp.org)
- Gastric mucosal calcinosis is a very rare pathologic diagnosis and we aimed to present this case with reference to the literature data. (heighpubs.org)
- Calcinosis had been recognized 18 months after the diagnosis was made (Fig. 1 ). (biomedcentral.com)
- Tumoral calcinosis is always the diagnosis of exclusion. (jbstjournal.com)
- 2 Subcutaneous calcinosis, as part of the CREST variant or diffuse variant, is often seen on the extensor surfaces and in areas that tend to have a lot of friction and is seen in approximately 58% of scleroderma patients. (appliedradiology.com)
- 7 The combination of calcinosis and acro-osteolysis, as seen in Figure 2, is considered to be pathognomic for scleroderma. (appliedradiology.com)
- Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report. (annals.org)
- We describe a case of PSC occurring in a patient with CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia) syndrome, which is a type of limited cutaneous scleroderma. (biomedcentral.com)
- The aim of the study is firstly to determine prevalence of calcinosis cutis, with hand and feet radiography realisation in a cohort of systemic sclerosis patient. (clinicaltrials.gov)
- Jeziorska, "Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis ," Rheumatology, vol. (thefreedictionary.com)
- Calcinosis cutis is associated with systemic sclerosis. (statpearls.com)
- Calcinosis cutis commonly occurs in patients with systemic sclerosis, especially the limited form (CREST). (statpearls.com)
- Twenty-five percent to 40% of patients with limited systemic sclerosis will develop calcinosis cutis ten years after the onset of disease. (statpearls.com)
- Al-Khudairi N et al: A case of symptomatic cervical spine calcinosis in systemic sclerosis. (statdx.com)
- Sambataro D et al: Tumoral calcinosis of the spine in the course of systemic sclerosis: report of a new case and review of the literature. (statdx.com)
- Association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis-related calcinosis. (cdc.gov)
- Iatrogenic calcinosis cutis is the deposition of calcium salts in the skin as a side effect of medical intervention for other disease processes. (uptodate.com)
- We present a rare case of iatrogenic calcinosis cutis complicated by compartment syndrome secondary to extravasation of iv calcium gluconate in a neonate. (biomedsearch.com)
- Tumoral calcinosis presents as large, painless periarticular calcifications, most commonly in the hips and shoulders. (clinicaladvisor.com)
- B ) Radiograph of the lesion revealed a soft tissue mass with amorphous calcifications around the right greater trochanter consistent with tumoral calcinosis. (jci.org)
- Reciprocally tumoral calcinosis (TC) patients are often hyperphosphatemic with inappropriately normal or elevated serum 1,25(OH) 2 D 3 levels and have eciopic and vascular calcifications, a phenotype similar to that of Fgf23 null mice. (elsevier.com)
- 12. Bittmann S, Gunther M, Ulus H. Tumoral calcinosis of the gluteal region in a child: Case report with overview of different soft-tissue calcifications. (jbstjournal.com)
- The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. (biomedcentral.com)
- Here we report a case of idiopathic calcinosis cutis of the scrotum with a brief review of the literature and a discussion on pathogenesis. (biomedcentral.com)
- Our understanding of the pathogenesis of calcinosis is still very limited. (biomedcentral.com)
- 7. Smack D, Norton S, Fitzpatrick J. Proposal for a pathogenesis-based classification of tumoral calcinosis. (jbstjournal.com)
- Idiopathic calcinosis cutis of the scrotum is an uncommon entity. (biomedcentral.com)
- Calcinosis cutis is an uncommon disorder characterized deposition of crystals of calsium phosphate (hydroxyapatite) in the skin in various areas of the body. (biomedcentral.com)
- Calcinosis cutis is an uncommon disorder which results in progressive deposition of insoluble calsium salts (crystals of calcium phosphate, hydroxyapatite) in the skin. (biomedcentral.com)
- On physical examination, calcinosis cutis' dermal calcium deposits present as numerous, firm dermal or subcutaneous papules, nodules, or plaques with either a white or yellow coloring (Figure 1, Figure 2). (clinicaladvisor.com)
- Subdermal nodules and papules of calcium deposition on the posterior upper thigh of a patient with calcinosis cutis. (clinicaladvisor.com)
- Subepidermal calcified nodules or Winder nodular calcinosis presents in children and can present at birth. (statpearls.com)
- Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. (macquariestemcells.com)
- She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules. (macquariestemcells.com)
- As cutaneous manifestations, aside from lesions compatible with Gottron's papules on upper extremities, the patient presented with "calcinosis cutis" consisting of scattered nodules and plaques, some ulcerated and suppurating in both gluteal regions and on right elbow. (reumatologiaclinica.org)
- To assess baseline cortical area and cortical porosity measured by HR-pQCT in SSc patients with calcinosis. (clinicaltrials.gov)
- In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calcinosis cutis, Raynaud phenomenon, sclerodactyly, and telangiectasia) syndrome in English by Winterbauer who, in 1964, described a series of 8 patients with the features that make up the abbreviation CRST. (medscape.com)
- Pharmacist pharmacist was reduced and equivalent however stopped in calcinosis commonly four patients after prednisone. (auto-uitlaat.be)
- Background: Uremic tumoral calcinosis (UTC) has been analyzed in uremic patients on hemodialysis, but little is known about UTC in peritoneal dialysis (PD). (elsevier.com)
- Differences between patients with and without calcinosis were analyzed with t-test or Wilcoxon Rank Sum tests for continuous variables as appropriate, while comparisons for categorical variables used Chi-square or Fisher's Exact tests as appropriate. (acrabstracts.org)
- Of 652 JDM patients, 601 contained requisite data on calcinosis. (acrabstracts.org)
- In total, 84 patients (14%) had a history of calcinosis. (acrabstracts.org)
- In multivariate analysis, differences in the distribution of proportions retained significance in patients with calcinosis for measures of delayed time to treatment (OR 1.5, CI 1.3-1.8), male gender (OR 1.75, CI 1.02-3.03), and African-American race (OR 2.5, CI 1.3-4.8). (acrabstracts.org)
- In this registry, one of the largest JDM and calcinosis cohorts, patients with a history of calcinosis are more likely to have received certain biologic agents than those without. (acrabstracts.org)
- Pets with calcinosis cutis typically have lesions (papules or plaques) with a gritty rough surface which may be quite itchy. (vcahospitals.com)
- Others had significant improvement in calcinosis with no new lesions, decreased sites and density and decreased calcinosis related contractures. (scirp.org)
- Generalized calcinosis rapidly progressed with high fever, multiple skin/subcutaneous inflammatory lesions, and increased level of CRP. (biomedcentral.com)
- Because calcinosis cutis are not always well defined, a recurrence of the lesions may occur. (biomedcentral.com)
- Deeply basophilic crystalline subcutaneous calcium depositions in a patient with calcinosis cutis. (clinicaladvisor.com)
- One patient had complete clearance of calcinosis for the last 5 years. (scirp.org)
- In this case, gastric mucosal calcinosis was diagnosed with endoscopic biopsy performed for a patient who presented to our clinic with heartburn and abdominal discomfort. (heighpubs.org)
- If calcinosis deposits do not cause discomfort or impede function, they may not require treatment and can be left alone if the patient so desires. (sclerodermanews.com)
- Remy-Leroux V et al: [Tumoral calcinosis at an unusual site in a haemodialysis patient. (statdx.com)
- A better understanding of the process of calcinosis cutis will lead to therapies to improve patient morbidity. (biomedcentral.com)
- Three months later, the patient showed a dramatic improvement in symptoms with softening of the calcinosis, reduced pain, and marked increase in joint mobility. (elsevier.com)
- We compared those with any history of calcinosis to those with no history, in respect to demographics, disease features, patient-reported outcome measures and treatment with biologic agents. (acrabstracts.org)
- Calcinosis cutis complicated by compartment syndrome following extravasation of calcium gluconate in a neonate: a case report. (biomedsearch.com)
- To the best of our knowledge, there were no previous case reports of calcinosis cutis with compartment syndrome in infants. (biomedsearch.com)
- CREST (calcinosis, Raynaud phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia) syndrome comprising calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia and primary sclerosing cholangitis are both chronic fibrotic diseases but the association between them is extremely rare. (biomedcentral.com)
- Calcinosis is the formation of calcium deposits in any soft tissue. (wikipedia.org)
- Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location i.e. around joints. (wikipedia.org)
- Calcinosis may also develop in the soft tissue of the feet, legs, and hands. (medlineplus.gov)
- Calcinosis typically develops in early childhood to early adulthood, although in some people the deposits first appear in infancy or in late adulthood. (medlineplus.gov)
- Calcinosis results when the excess phosphate combines with calcium to form deposits that build up in soft tissues. (medlineplus.gov)
- Bilateral striopallidodentate calcinosis (BSPDC, also erroneously called Fahr disease) is characterized by the accumulation of calcium deposits in different brain regions, particularly the basal ganglia and dentate nucleus, and is often associated with neurodegeneration. (orpha.net)
- People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. (clinicaltrials.gov)
- Calcinosis or calcinosis cutis is the accumulation of calcium deposits in or under the skin. (sclerodermanews.com)
- Calcinosis deposits occasionally resolve themselves spontaneously . (sclerodermanews.com)
- If calcinosis deposits become very painful, cause recurrent secondary infections or impair function, a doctor may recommend surgical removal . (sclerodermanews.com)
- Calcinosis is a condition that manifests as calcium deposits in the skin and other tissues of the body. (medindia.net)
- Over the 18 months of observation up to the present, she has had no inflammatory calcinosis, or needed any hospitalization, although established calcium deposits still remain. (biomedcentral.com)