Organic Cation Transport Proteins
Cation Transport Proteins
Biological Transport, Active
Fatty Acid Transport Proteins
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Membrane Transport Proteins
Organic Cation Transporter 1
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Monosaccharide Transport Proteins
Equilibrative Nucleoside Transport Proteins
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Anion Transport Proteins
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Cell Membrane Permeability
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Kidney Tubules, Proximal
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Vesicular Transport Proteins
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
ATP-Binding Cassette Transporters
Glucose Transport Proteins, Facilitative
Organic Anion Transporters
Amino Acid Transport Systems
Dose-Response Relationship, Drug
Multidrug Resistance-Associated Proteins
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Sequence Homology, Amino Acid
Nucleotide Transport Proteins
Nucleoside Transport Proteins
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Periplasmic Binding Proteins
TRPM Cation Channels
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Amino Acid Transport Systems, Basic
Amino Acid Transport Systems, Neutral
Vesicular Biogenic Amine Transport Proteins
Dicarboxylic Acid Transporters
TRPV Cation Channels
GABA Plasma Membrane Transport Proteins
A family of plasma membrane neurotransmitter transporter proteins that regulates extracellular levels of the inhibitory neurotransmitter GAMMA-AMINOBUTYRIC ACID. They differ from GABA RECEPTORS, which signal cellular responses to GAMMA-AMINOBUTYRIC ACID. They control GABA reuptake into PRESYNAPTIC TERMINALS in the CENTRAL NERVOUS SYSTEM through high-affinity sodium-dependent transport.
Recombinant Fusion Proteins
Active Transport, Cell Nucleus
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
TRPC Cation Channels
A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Folate Receptors, GPI-Anchored
Glucose Transporter Type 1
Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Quaternary Ammonium Compounds
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Electrophoresis, Polyacrylamide Gel
Organic Anion Transporters, Sodium-Independent
Saccharomyces cerevisiae Proteins
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Solute Carrier Family 12, Member 1
Genetic Complementation Test
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Monocarboxylic Acid Transporters
Drug Resistance, Multiple
Catecholamine Plasma Membrane Transport Proteins
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Protein Structure, Secondary
Membrane Transport Modulators
Amino Acid Transport System X-AG
Gene Expression Regulation
Gene Expression Regulation, Bacterial
Organic Anion Transport Polypeptide C
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Role of iron in Nramp1-mediated inhibition of mycobacterial growth. (1/3516)Innate resistance to mycobacterial growth is mediated by a gene, Nramp1. We have previously reported that Nramp1 mRNA from macrophages of Mycobacterium bovis BCG-resistant (Bcgr) mice is more stable than Nramp1 mRNA from macrophages of BCG-susceptible (Bcgs) mice. Based on these observations and on reports that show that the closely related Nramp2 gene is a metal ion transporter, we evaluated the effect of iron on the growth of Mycobacterium avium within macrophages as well as on the stability of Nramp1 mRNA. The addition of iron to macrophages from Bcgs mice resulted in a stimulation of mycobacterial growth. In contrast, iron increased the capacity of macrophages from Bcgr mice to control the growth of M. avium. When we treated recombinant gamma interferon (IFN-gamma)-activated macrophages with iron, we found that iron abrogated the growth inhibitory effect of IFN-gamma-activated macrophages from Bcgs mice but that it did not affect the capacity of macrophages from Bcgr mice to control microbial growth. A more detailed examination of the effect of iron on microbial growth showed that the addition of small quantities of iron to resident macrophages from Bcgr mice stimulated antimicrobial activity within a very narrow dose range. The effect of iron on the growth inhibitory activity of macrophages from Bcgr mice was abrogated by the addition of catalase or mannitol to the culture medium. These results are consistent with an Fe(II)-mediated stimulation of the Fenton/Haber-Weiss reaction and hydroxyl radical-mediated inhibition of mycobacterial growth. (+info)
Characterisation of copper-binding to the second sub-domain of the Menkes protein ATPase (MNKr2). (2/3516)The Menkes ATPase (MNK) has an essential role in the translocation of copper across cellular membranes. In a complementary manner, the intracellular concentration of copper regulates the activity and cellular location of the ATPase through its six homologous amino-terminal domains. The roles of the six amino-terminal domains in the activation and cellular trafficking processes are unknown. Understanding the role of these domains relies on the development of an understanding of their metal-binding properties and structural properties. The second conserved sub-domain of MNK was over-expressed, purified and its copper-binding properties characterised. Reconstitution studies demonstrate that copper binds to MNKr2 as Cu(I) with a stoichiometry of one copper per domain. This is the first direct evidence of copper-binding to the MNK amino-terminal repeats. Circular dichroism studies suggest that the binding or loss of copper to MNKr2 does not cause substantial changes to the secondary structure of the protein. (+info)
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. (3/3516)The natural resistance associated macrophage protein (Nramp) gene family is composed of two members in mammals, Nramp1 and Nramp2. Nramp1 is expressed primarily in macrophages and mutations at this locus cause susceptibility to infectious diseases. Nramp2 has a much broader range of tissue expression and mutations at Nramp2 result in iron deficiency, indicating a role for Nramp2 in iron metabolism. To get further insight into the function and mechanism of action of Nramp proteins, we have generated isoform specific anti-Nramp1 and anti-Nramp2 antisera. Immunoblotting experiments indicate that Nramp2 is present in a number of cell types, including hemopoietic precursors, and is coexpressed with Nramp1 in primary macrophages and macrophage cell lines. Nramp2 is expressed as a 90-100-kD integral membrane protein extensively modified by glycosylation (>40% of molecular mass). Subcellular localization studies by immunofluorescence and confocal microscopy indicate distinct and nonoverlapping localization for Nramp1 and Nramp2. Nramp1 is expressed in the lysosomal compartment, whereas Nramp2 is not detectable in the lysosomes but is expressed primarily in recycling endosomes and also, to a lower extent, at the plasma membrane, colocalizing with transferrin. These findings suggest that Nramp2 plays a key role in the metabolism of transferrin-bound iron by transporting free Fe2+ across the endosomal membrane and into the cytoplasm. (+info)
Genetic selection of mutations in the high affinity K+ transporter HKT1 that define functions of a loop site for reduced Na+ permeability and increased Na+ tolerance. (4/3516)Potassium is an important macronutrient required for plant growth, whereas sodium (Na+) can be toxic at high concentrations. The wheat K+ uptake transporter HKT1 has been shown to function in yeast and oocytes as a high affinity K+-Na+ cotransporter, and as a low affinity Na+ transporter at high external Na+. A previous study showed that point mutations in HKT1, which confer enhancement of Na+ tolerance to yeast, can be isolated by genetic selection. Here we report on the isolation of mutations in new domains of HKT1 showing further large increases in Na+ tolerance. By selection in a Na+ ATPase deletion mutant of yeast that shows a high Na+ sensitivity, new HKT1 mutants at positions Gln-270 and Asn-365 were isolated. Several independent mutations were isolated at the Asn-365 site. N365S dramatically increased Na+ tolerance in yeast compared with all other HKT1 mutants. Cation uptake experiments in yeast and biophysical characterization in Xenopus oocytes showed that the mechanisms underlying the Na+ tolerance conferred by the N365S mutant were: reduced inhibition of high affinity Rb+ (K+) uptake at high Na+ concentrations, reduced low affinity Na+ uptake, and reduced Na+ to K+ content ratios in yeast. In addition, the N365S mutant could be clearly distinguished from less Na+-tolerant HKT1 mutants by a markedly decreased relative permeability for Na+ at high Na+ concentrations. The new mutations contribute to the identification of new functional domains and an amino acid in a loop domain that is involved in cation specificity of a plant high affinity K+ transporter and will be valuable for molecular analyses of Na+ transport mechanisms and stress in plants. (+info)
Overexpression of a novel Arabidopsis gene related to putative zinc-transporter genes from animals can lead to enhanced zinc resistance and accumulation. (5/3516)We describe the isolation of an Arabidopsis gene that is closely related to the animal ZnT genes (Zn transporter). The protein encoded by the ZAT (Zn transporter of Arabidopsis thaliana) gene has 398 amino acid residues and is predicted to have six membrane-spanning domains. To obtain evidence for the postulated function of the Arabidopsis gene, transgenic plants with the ZAT coding sequence under control of the cauliflower mosaic virus 35S promoter were analyzed. Plants obtained with ZAT in the sense orientation exhibited enhanced Zn resistance and strongly increased Zn content in the roots under high Zn exposure. Antisense mRNA-producing plants were viable, with a wild-type level of Zn resistance and content, like plants expressing a truncated coding sequence lacking the C-terminal cytoplasmic domain of the protein. The availability of ZAT can lead to a better understanding of the mechanism of Zn homeostasis and resistance in plants. (+info)
Ion channels: structure of a molecular brake. (6/3516)A combination of crystallographic and mutagenesis studies on the HERG K+ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino-terminal domain might act as a 'molecular brake' that slows down channel deactivation. (+info)
Cloning and characterization of the transport modifier RS1 from rabbit which was previously assumed to be specific for Na+-D-glucose cotransport. (7/3516)Previously we cloned membrane associated polypeptides from pig and man (pRS1, hRS1) which altered rate and glucose dependence of Na+-d-glucose cotransport expressed by SGLT1 from rabbit and man. This paper describes the cloning of a related cDNA sequence from rabbit intestine (rbRS1) which encodes a gene product with about 65% amino acid identity to pRS1 and hRS1. Hybridization of endonuclease-restricted genomic DNA with cDNA fragments of rbRS1 showed that there is only one gene with similarity to rbRS1 in rabbit, and genomic PCR amplifications revealed that the rbRS1 gene is intronless. Comparing the transcription of rbRS1 and rbSGLT1 in various tissues and cell types, different mRNA patterns were obtained for both genes. In Xenopus oocytes the Vmax of expressed Na+-d-glucose cotransport was increased or decreased when rbRS1 was coexpressed with rbSGLT1 or hSGLT1, respectively. After coexpression with hSGLT1 the glucose dependence of the expressed transport was changed. By coexpression of rbRS1 with the human organic cation transporter hOCT2 the expressed cation uptake was not altered; however, the expressed cation uptake was drastically decreased when hRS1 was coexpressed with hOCT2. The data show that RS1 can modulate the function of transporters with non-homologous primary structures. (+info)
Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. (8/3516)Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by tissue iron deposition secondary to excessive dietary iron absorption. We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Here, we tested the hypothesis that HFE-/- mice have increased duodenal expression of the divalent metal transporter (DMT1). By 4 weeks of age, the HFE-/- mice demonstrated iron loading when compared with HFE+/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated liver iron concentrations (985 micrograms vs. 381 micrograms). By using Northern blot analyses, we quantitated duodenal expression of both classes of DMT1 transcripts: one containing an iron responsive element (IRE), called DMT1(IRE), and one containing no IRE, called DMT1(non-IRE). The positive control for DMT1 up-regulation was a murine model of dietary iron deficiency that demonstrated greatly increased levels of duodenal DMT1(IRE) mRNA. HFE-/- mice also demonstrated an increase in duodenal DMT1(IRE) mRNA (average 7.7-fold), despite their elevated transferrin saturation and hepatic iron content. Duodenal expression of DMT1(non-IRE) was not increased, nor was hepatic expression of DMT1 increased. These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron. (+info)
Mn tolerance in rice is mediated by MTP8.1, a member of the cation diffusion facilitator family<...
TY - JOUR. T1 - Mn tolerance in rice is mediated by MTP8.1, a member of the cation diffusion facilitator family. AU - Chen, Zonghui. AU - Fujii, Yumi. AU - Yamaji, Naoki. AU - Masuda, Sakine. AU - Takemoto, Yuma. AU - Kamiya, Takehiro. AU - Yusuyin, Yusufujiang. AU - Iwasaki, Kozo. AU - Kato, Shin Ichiro. AU - Maeshima, Masayoshi. AU - Ma, Jian Feng. AU - Ueno, Daisei. PY - 2013/11. Y1 - 2013/11. N2 - Manganese (Mn) is an essential micronutrient for plants, but is toxic when present in excess. The rice plant (Oryza sativa L.) accumulates high concentrations of Mn in the aerial parts; however, the molecular basis for Mn tolerance is poorly understood. In the present study, genes encoding Mn tolerance were screened for by expressing cDNAs of genes from rice shoots in Saccharomyces cerevisiae. A gene encoding a cation diffusion facilitator (CDF) family member, OsMTP8.1, was isolated, and its expression was found to enhance Mn accumulation and tolerance in S. cer-evisiae. In plants, OsMTP8.1 and its ...
NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine...
The Lsh/Ity/Bcg locus on mouse chromosome 1 regulates macrophage (m phi) priming/activation for antimicrobial activity against intracellular pathogens. A candidate Bcg gene, designated natural resistance-associated m phi protein (Nramp), recently isolated from a pre-B cell cDNA library encodes a polytopic integral membrane protein with structural features common to prokaryotic and eukaryotic transporters. In the present study, an activated m phi cDNA library yielded new Nramp clones that differ in the 5 region from the published pre-B cell-derived clone sequence, resulting in addition of 64 amino acids at the NH2 terminus of the predicted protein. This new domain is rich in proline, serine, and basic amino acids, and includes three protein kinase C phosphorylation sites and a putative Src homology 3 binding domain. RNAs containing this domain are the only form found in the m phi. Hence, the protein encoded by this RNA is the candidate molecule mediating natural resistance to intra-m phi ...
Medicago truncatula Natural Resistance-Associated Macrophage Protein1 Is Required for Iron Uptake by Rhizobia-Infected Nodule...
Legumes are key to world agriculture (Graham and Vance, 2003). They are the main protein source in many areas of the world and, because of SNF, a viable alternative to the use of nitrogen fertilizers in agriculture (Smil, 1999). As in any plant, iron uptake and systemic distribution is critical in legumes. Like in other nongraminaceous plants, in legumes, iron uptake from soil follows what is known as Strategy I, i.e. Fe3+ solubility is increased by acidification of the surrounding soil and then Fe3+ is reduced by a ferroreductase to Fe2+, which is imported into plants via specific transporters in the root epidermis (Andaluz et al., 2009). Once inside the plant, iron is used in legumes as in other plants, with one exception; in addition to the shoot, there is an extra iron sink during vegetative stages of growth, namely the root nodule (Tang et al., 1990).. Nodulation requires relatively large amounts of iron to synthesize the key enzymes involved in SNF (Brear et al., 2013; González-Guerrero ...
Saccharomyces cerevisiae Expresses Three Functionally Distinct Homologues of the Nramp Family of Metal Transporters | Molecular...
Nramp (for natural resistance-associated macrophage protein) represents a family of evolutionarily conserved membrane proteins that facilitate the transport of heavy metal ions (5, 6, 15, 17, 31). Members of the Nramp family have been found in mammals, birds, insects, plants, fungi, and bacteria (3, 5, 9, 15, 16, 22, 40). Among the best studied are the Nramp1 and Nramp2 transporters of rodents. Although these proteins share 61% homology at the amino acid level, they exhibit distinct functions. Mouse Nramp1 plays an important role in the control of infection against intracellular parasites and is exclusively expressed in monocytes/macrophages and polymorphonuclear leukocytes (2, 15). Nramp2 (also known as DCT1 or DMT1) is more ubiquitously expressed in most tissues (17) and acts as a divalent metal transporter capable of transporting iron, manganese, copper, zinc, cadmium, and lead (17). Mutations inNramp2 have been associated with defects in duodenal iron uptake and cellular iron utilization in ...
Comparative study of the genomic organization of DNA repeats within the 5′-flanking region of the natural resistance-associated...
Read Comparative study of the genomic organization of DNA repeats within the 5′-flanking region of the natural resistance-associated macrophage protein gene (NRAMP1) between humans and great apes, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
CP000386.PE586 Location/Qualifiers FT CDS complement(625625..626515) FT /codon_start=1 FT /transl_table=11 FT /locus_tag=Rxyl_0596 FT /product=cation diffusion facilitator family transporter FT /note=TIGRFAM: cation diffusion facilitator family FT transporter; PFAM: cation efflux protein; KEGG: mbo:Mb2050c FT possible conserved membrane protein FT /db_xref=EnsemblGenomes-Gn:Rxyl_0596 FT /db_xref=EnsemblGenomes-Tr:ABG03567 FT /db_xref=GOA:Q1AYG1 FT /db_xref=InterPro:IPR002524 FT /db_xref=InterPro:IPR027469 FT /db_xref=InterPro:IPR036837 FT /db_xref=UniProtKB/TrEMBL:Q1AYG1 FT /protein_id=ABG03567.1 FT /translation=MRDRDALEASEQGIRAVKLSFAVLALTAVLQLAVALVSGSAALLA FT DTAHNFGDALTALPLWLAFALSRRPPSRTHTYGYGRAEDLAGAAIVGIILLSALVCGYE FT SATKLLEGSGVRGAGWVALAAAAGFAGNELAARLRISVGRRIGSAALVADGQHARTDGL FT TSLAVLAGAAGAWLGYPVVDPLVGLGITAAILHIVRDSARPVWRRLMDAVEPGTVEALE FT EAASGMPEVLRVEEVRARWTGHSLQAEVRVRVEPDLPAGRLGDLSGRLAAAARKRLPRL FT ERVLLEPVPDRPGDV MRDRDALEAS EQGIRAVKLS FAVLALTAVL QLAVALVSGS ...
DIGITAL.CSIC: Cloning and functional characterization of the high-affinity K+ transporter HAK1 of pepper
High-affinity K+ uptake in plants plays a crucial role in K+ nutrition and different systems have been postulated to contribute to the high-affinity K+ uptake. The results presented here with pepper (Capsicum annum) demonstrate that a HAK1-type transporter greatly contributes to the high-affinity K+ uptake observed in roots. Pepper plants starved of K+ for 3 d showed high-affinity K+ uptake (K m of 6 mgrM K+) that was very sensitive to NH and their roots expressed a high-affinity K+ transporter, CaHAK1, which clusters in group I of the KT/HAK/KUP family of transporters. When expressed in yeast (Saccharomyces cerevisiae), CaHAK1 mediated high-affinity K+ and Rb+ uptake with K m values of 3.3 and 1.9 mgr M, respectively. Rb+ uptake was competitively inhibited by micromolar concentrations of NH and Cs+, and by millimolar concentrations of Na+ ...
The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response...
NRAMPs (natural resistance-associated macrophage proteins) have been characterized in mammals as divalent transition metal transporters involved in iron metabolism and host resistance to certain pathogens. The mechanism of pathogen resistance is proposed to involve sequestration of Fe2+ and Mn2+, co …
Slc11a2 MGI Mouse Gene Detail - MGI:1345279 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member...
View mouse Slc11a2 Chr15:100387898-100424214 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
CHAPTER 9 - Binding, Transport and Storage of Metal Ions in Biological Cells (RSC Publishing)
complexation with the protein transferrin (Tf). Upon entering the blood, Mn is distributed diffusely throughout the body, with the brain, bone, kidneys and liver acquiring the highest accumulation. A variety of transporters regulate Mn import, including DMT1 or Tf-Tf receptor internalization, choline transporter, citrate transporter, voltage-gated and store-operated calcium channels, and the zinc transporters ZIP8/14. Recent findings suggest a role for the magnesium transporter HIP14 and the P-type transmembrane ATPase ATP13A2 in Mn uptake across cellular membranes. Mn serves as an important cofactor for many enzymes that are key in regulating general cellular function. Intracellular buffering mechanisms also include preferential sequestration within mitochondria. Finally, Mn export has yet to be fully understood, but new evidence points to the iron exporter ferroportin as a potential exporter. This chapter will address the various processes associated with maintenance of optimal Mn levels and ...
SLC11A1 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1) - KOMP (Knockout Mouse Project)
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Rachelle Gaudet - Harvard University - Department of Molecular & Cellular Biology
My lab is broadly interested in the mechanisms of signaling and transport across cellular membranes. Our research encompasses several protein families: Nramp transporters that use a proton gradient to facilitate the entry of divalent ions (iron and manganese in particular) into cells; non-classical cadherins involved in cellular adhesion and signaling; ABC transporters that use ATP to fuel substrate transport; and TRP channels important to sensing temperature and painful stimuli. We use a variety of cell-based and in vitro biochemical assays, x-ray crystallography, and computational techniques (molecular dynamics simulations and bioinformatics analyses) to discover how these important proteins function in cells. Below are brief descriptions that illustrate our approaches and goals for specific projects.. Nramp transporters. Metals like iron and manganese are essential to physiological processes such as oxygen transport and energy metabolism. Nramps (Natural Resistance-Associated Macrophage ...
Assessment of the Requirements for Magnesium Transporters in Bacillus subtilis | Journal of Bacteriology
Metal ions are a requirement for life due to their function as key cofactors in numerous cellular processes. However, these essential ions become an intracellular threat when present in excess. Their intracellular levels must therefore be carefully maintained. Many different studies have revealed how metal homeostasis mechanisms can be controlled (1-3). Typically, microbes sense intracellular metal concentrations through the action of metal-sensing regulatory (metalloregulatory) proteins. However, additional studies have identified at least two examples of RNA elements that also regulate the expression of metal ion transporter genes (4-6). In general, these RNA- and protein-based regulatory factors act together to maintain the correct balance of intracellular metals by controlling the expression of genes responsible for the uptake, efflux, and sequestration of target ions.. In general, divalent ions are maintained at relatively low concentrations in the cytoplasm, in part through the combined ...
Distribution of ferroportin1 protein in different regions of developing rat brain | PolyU Institutional Research Archive
Ferroportin1 is a newly discovered transmembrane iron export protein. It plays a key role in Fe2+transport across the basal membrane of enterocytes in the gut. It has been suggested that this protein might have the same role in Fe2+transport across the abluminal membrane of the blood-brain barrier as it works in enterocytes. However, the presence of ferroportin1 in the brain has not been well determined. In the present study, we investigated expression of ferroportin1 protein in different brain regions, including cortex, hippocampus, striatum and substantia nigra, in developing male Sprague-Dawley rats. The results provided direct evidence for the existence of ferroportin1 protein in the rat brain. All brain areas examined have the ability to synthesize ferroportin1 protein. The findings also showed that age has a significant effect on the expression of ferroportin1 protein in the cortex, hippocampus, striatum and substantia nigra of the rat brain ...
Earlier studies have indicated that sensitivity to the Pt drugs can be regulated by the Cu influx transporter CTR1 (3 , 4) and the Cu exporter ATP7B (5 , 10) . The results reported here indicate that another Cu transporter, ATP7A, is also capable of modulating sensitivity to this class of drugs and that this effect is observable in ovarian cancer cells. Furthermore, the results document that even a quite modest change in ATP7A level is pharmacodynamically significant. These findings provide additional support for the concept that the Cu transporters are important to the pharmacodynamics of the Pt-containing drugs and specifically identify small changes in ATP7A expression as being of relevance in ovarian cancer.. Western blot analysis of ovarian carcinoma cell lines selected in vitro for acquired resistance to DDP (10) and immunohistochemical analysis of ovarian carcinoma samples from patients failing DDP and/or CBDCA-containing primary chemotherapy (20) have demonstrated only modest changes in ...
Molecular Mechanisms of Intestinal Metal Ion Transport During Iron Deficiency - James Collins
Absorption of dietary iron in the doudenum determines overall body iron levels as no active excretory systems exist. As such, this process must be tightly contr...
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eCite - The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidinerich N-terminal region that potentially...
The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidinerich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum
Citation tools | Infection and Immunity
Chlosta, Sabine et al The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica. Infection and Immunity 74.5 (2006): 3065-3067. Web. 12 Nov. 2019. ...
5ayn » Iron-regulated transporter, outward-facing state - Orientations of Proteins in Membranes (OPM) database
A - Tilt: 8° - Segments: 1( 11- 35), 2( 44- 65), 3( 78- 98), 4( 110- 135), 5( 155- 176), 6( 188- 206), 7( 244- 255), 8( 281- 301), 9( 310- 331), 10( 336- 359), 11( 375- 396), 12( 401- 421 ...
Rhesus Proteins Transport Ions, not Gas
The results can, in a large part, be transferred to the Rhesus proteins from mammals, says Andrade as Amt proteins bear a close resemblance to the Rhesus proteins found in humans. They are produced in the blood, in the kidney, and in the liver, where they regulate the intake of ammonium and thus the bodys pH.. The researchers tested three Amt proteins that are present in the bacteria and also determined the speed with which they allow ammonium to pass through the membrane. In the future, we want to modify individual components of the transporter to improve our understanding of the exact molecular details involved explains Andrade.. The scientific debate on Amt/Rh proteins stems from the difficulty of distinguishing between ammonia and ammonium in measurements, as the two molecules are transformed into each other in a continuous state of balance with protons. Our in vitro method gives us a level of precision that finally allows us to draw valid conclusions concerning the transport process, ...
TCDB » SEARCH
Heavy metal (Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ and Pb2+) ion:H+ symporter, Nramp2 or divalent metal transporter, DMT1 (Garrick et al. 2003). A 12 TMS topology with intracellular N- and C- termini is established. Two-fold structural symmetry in the arrangement of membrane helices for TM1-5 and TM6-10 (conserved Slc11 hydrophobic core) is suggested (Czachorowski et al., 2009). A conserved motif in a central flexible region of TMS1 (DPGN) binds the metal ion (Wang et al. 2011). Upregulated by iron deficiency and downregulated by iron loading (Nam et al. 2013). NRAMP2 also serves as the Sindbis alpha virus receptor (Rose et al. 2011). DMT1 interacts with the iron chaparone protein, PCBP2 (Q15366), in an iron-dependent fashion, and may be essential for iron uptake (Lane and Richardson 2014). Mutations cause a syndrome of congenital microcytic hypochromic anemia, poorly responsive to oral iron treatment, with liver iron overload associated paradoxically with normal to moderately elevated serum ...
Ferroportin/SLC40A1 Antibodies: Novus Biologicals
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Ferroportin/SLC40A1 Antibodies: Novus Biologicals
Ferroportin/SLC40A1 Antibodies available through Novus Biologicals. Browse our Ferroportin/SLC40A1 Antibody catalog backed by our Guarantee+.
Bacterial zinc transporters and regulators
Zn2+ homeostasis in bacteria is achieved by export systems and uptake systems which are separately regulated by their own regulators. Three types of Zn2+ export systems that protect cells from high toxic concentrations of Zn2+ have been identified: RND multi-drug efflux transporters, P-type ATPases, …
Zinc transporter 2 / SLC30A2 antibody | acris-antibodies.com
Kit Component:- KN202646G1, SLC30A2 gRNA vector 1 in pCas-Guide vector- KN202646G2, SLC30A2 gRNA vector 2 in pCas-Guide vector- KN202646D, donor…
Zinc transporter 2 / SLC30A2 antibody | acris-antibodies.com
Kit Component:- KN202646G1, SLC30A2 gRNA vector 1 in pCas-Guide vector- KN202646G2, SLC30A2 gRNA vector 2 in pCas-Guide vector- KN202646D, donor…
Discussion Summary #2: Menjaga Hak Konstitusi Untuk Mewujudkan Keadilan Pemilu Di Tengah Pandemi Covid-19 - KOMITE INDEPENDEN...
Komite Independen Sadar Pemilu (KISP) merilis Discussion Summary #2 yang merupakan hasil kajian dari Ngaji Pemilu #2: Menjaga Hak Konstitusi Untuk Mewujudkan Keadilan Pemilu Di Tengah Pandemi Covid-19 yang dilaksanakan pada 09 Mei 2020.. Discussion Summary #2 ini berisi analisis terkait dengan konsep keadilan pemilu; sengketa pemilu, pilkada dan penegakan hukum; serta problematika pilkada di tengah pandemi Covid-19.. Lebih lengkapnya, Discussion Summary #2 dapat diunduh pada link di bawah ini: ...
Ferroportin /SLC40A1 | ALZFORUM
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
Gentaur Molecular :SBI \ miRZip 605 anti miR 605 microRNA construct \ MZIP605-PA-1
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vynechanie HAK | Zdravý svet
dobry den, rok som uzivala antikoncepciu Chloe a lekar mi ju potom vymenil za Zenadeu a pocas jej uzivania som nedostala ani raz menzes ( su tomu...
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NOLDEX Szervező és Szolgáltató Zrt.
NOLDEX Szervező és Szolgáltató ZRt., Üzleti folyamatok újraszervezése (BPR), SAP rendszerbevezetés, Egyedi szoftver fejlesztés
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Jira Misc Custom Fields (JMCF) Excel Reports - Better Excel Exporter for Jira | Midori
Better Excel Exporter exports all Jira Misc Custom Fields to Excel allowing for sharing and analyzing JMCF data with Excel features.
NewYork-Presbyterian Queens - Common Variable Immunodeficiency (CVID)
CVID is an immunodeficiency disorder characterized by a low level of antibodies, making it difficult for the childs body to fight diseases. The child then becomes sick with recurrent infections. The disease may become evident during infancy, during childhood or puberty, or even later into adulthood. The symptoms of the disease are very different for each child affected, which is why it is called a variable group of disorders.. ...
Functional properties of the human copper-transporting ATPase ATP7B (the Wilsons disease protein) and regulation by...
TY - JOUR. T1 - Functional properties of the human copper-transporting ATPase ATP7B (the Wilsons disease protein) and regulation by metallochaperone Atox1. AU - Lutsenko, Svetlana. AU - Tsivkovskii, Ruslan. AU - Walker, Joel M.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2003. Y1 - 2003. N2 - Wilsons disease protein (WNDP) is a copper-transporting P1-type ATPase which plays a key role in normal distribution of copper in a number of tissues, particularly in the liver and the brain. Copper has numerous effects on WNDP, altering its structure, activity, and intracellular localization. To better understand the function of this copper-transporting ATPase and its regulation by copper, we have recently developed the functional expression systems for WNDP and for Atox1, a cytosolic protein that serves as an intracellular donor of copper for WNDP. Here we summarize the results of our experiments on characterization of the enzymatic properties of WNDP and the effects of ...
The cation diffusion facilitator family protein EmfA confers resistance to manganese toxicity in Brucella abortus 2308 and is...
Brucella abortus is a Gram-negative bacterium that causes abortion and infertility in food animals and a chronic debilitating febrile disease in humans known as brucellosis. As with all pathogenic bacteria, the Brucella spp. require sufficient metal nutrition during the course of an infection. Host-mediated metal withdrawal defenses actively restrict the bioavailability of metals which requires invading bacteria to employ high affinity metal acquisition systems to overcome these metal-limiting conditions. While obtaining sufficient metals during host infection is critical to the survival of these bacteria, avoiding metal toxicity is equally important. Excess accumulation of one metal relative to others can lead to protein mis-metallation when surplus metal ions outcompete other metal species for their native binding sites. To prevent metal toxicity, bacteria respond to high intracellular metal concentrations by means of metal-responsive transcriptional regulators that downregulate metal import ...
Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals<...
TY - JOUR. T1 - Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. AU - Liang, Zheng Dong. AU - Long, Yan. AU - Chen, Helen H W. AU - Savaraj, Niramol. AU - Kuo, Macus Tien. PY - 2014/1/14. Y1 - 2014/1/14. N2 - Platinum-based antitumor agents have been the mainstay in cancer chemotherapy for many human malignancies. Drug resistance is an important obstacle to achieving the maximal therapeutic efficacy of these drugs. Understanding how platinum drugs enter cells is of great importance in improving therapeutic efficacy. It has been demonstrated that human high-affinity copper transporter 1 (hCtr1) is involved in transporting cisplatin into cells to elicit cytotoxic effects, although other mechanisms may exist. In this communication, we demonstrate that cisplatin transcriptionally induces the expression of hCtr1 in time- and concentration-dependent manners. Cisplatin functions as a competitor for hCtr1-mediated copper transport, resulting in reduced ...
Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with...
PubMedID: 23039265 | Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with preserved beta cell function at diagnosis of diabetes. | Autoimmunity | 2/1/2013
Metal binding to the dynamic cytoplasmic domain of the cation diffusion facilitator (CDF) protein MamM induces a locked-in...
Cation diffusion facilitator (CDF) proteins are a conserved family of transmembrane transporters that ensure cellular homeostasis of divalent transition metal cations. Metal cations bind to CDF proteins cytoplasmic C-terminal domain (CTD), leading to closure from its apo open V-shaped dimer to a tighter packed structure, followed by a conformational change of the transmembrane domain thus enabling transport of the metal cation. By implementing a comprehensive range of biochemical and biophysical methods, we studied the molecular mechanism of metal binding to the magnetotactic bacterial CDF protein MamM CTD. Our results reveal that the CTD is rather dynamic in its apo form, and that two dependent metal binding sites, a single central binding site and two symmetrical, peripheral sites, are available for metal binding. However, only cation binding to the peripheral sites leads to conformational changes that lock the protein in a compact state. Thus, this work reveals how metal binding is ...
Zinc Transporter ZIP14 Functions in Hepatic Zinc, Iron and Glucose Homeostasis during the Innate Immune Response Endotoxemia -...
Zinc Transporter ZIP14 Functions in Hepatic Zinc, Iron and Glucose Homeostasis during the Innate Immune Response Endotoxemia. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCTR1) - Metallomics (RSC Publishing)
Copper transporter 1 (CTR1) is a transmembrane protein that imports copper(i) into yeast and mammalian cells. Surprisingly, the protein also mediates the uptake of platinum anticancer drugs, e.g. cisplatin and carboplatin. To study the effects of several metal-binding residues/motifs of hCTR1 on the transpor Metals and Genetics
Copper transport protein and inflammatory angiogenesis - Augusta University Research Profiles
DESCRIPTION (provided by applicant): The overall aim of this grant is to elucidate the novel linkage between copper transport protein Antioxidant1 (Atox1) and NADPH oxidase involved in inflammatory angiogenesis. Ischemic disease is a leading cause of morbidity and mortality in worldwide. Neovascularization is an important repair process in response to ischemia, which depends on angiogenesis, inflammation and reactive oxygen species (ROS). Copper (Cu), an essential micronutrient, is involved in physiological repair processes such as wound healing and angiogenesis as well as in various pathophysiologies including tumor growth, atherosclerosis and inflammatory diseases. Since excess Cu is toxic, bioavailability of intracellular Cu is tightly controlled by Cu transport proteins such as Cu chaperone Atox1. Our laboratories provided the first evidence that Atox1 functions as a Cu-dependent transcription factor to regulate Cu-induced cell growth. Furthermore, we are one of the first to demonstrate that ...
In silico identification and expression of SLC30 family genes: An expressed sequence tag data mining strategy for the...
Intracellular zinc concentration and localization are strictly regulated by two main protein components, metallothioneins and membrane transporters. In mammalian cells, two membrane transporters family are involved in intracellular zinc homeostasis: the uptake transporters called SLC39 or Zip family and the efflux transporters called SLC30 or ZnT family. ZnT proteins are members of the cation diffusion facilitator (CDF) family of metal ion transporters. From genomic databanks analysis, we identified the full-length sequences of two novel SLC30 genes, SLC30A8 and SLC30A10, extending the SLC30 family to ten members. We used an expressed sequence tag (EST) data mining strategy to determine the pattern of ZnT genes expression in tissues. In silico results obtained for already studied ZnT sequences were compared to experimental data, previously published. We determined an overall good correlation with expression pattern obtained by RT-PCR or immunomethods, particularly for highly tissue specific genes. The
Zinc transporter ZIP8
This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008 ...
Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin | Haematologica
Our present findings suggest that the ferroportin Q248H mutant is resistant to physiological concentrations of hepcidin (0.01-0.03 μM),12-15 despite bioinformatic predictions suggesting that it is a neutral polymorphism. We observed this with both human myc-tagged ferroportin and ferroportin fused to EGFP that were expressed in 293T cells treated with hepcidin and detected by immunoblotting or EGFP fluorescence. These observations were further supported by analysis of intracellular ferritin that reflects the amount of iron stored within the cells. The hepcidin-mediated increase of ferritin was less pronounced in 293T cells that expressed ferroportin Q248H compared to cells that expressed WT ferroportin. Analysis of ferritin levels in primary macrophages differentiated from primary human monocytes after incubation with iron and a short exposure to hepcidin showed a dose-dependent association with ferroportin genotype. No increase in macrophage ferritin was observed with homozygous ferroportin ...
118 68. Tchernitchko D, Bourgeois M, Martin ME, Beaumont C. Expression of the two mRN A isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element. Biochem J. 2002;363:449 55. 69. Canonne Hergaux F, Gruenheid S, Ponka P, Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 1999;93:4406 17. 70. Canonne Hergaux F, Zhang AS, Ponka P, Gros P. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001;9 8:3823 30. 71. Gruenheid S, Canonne Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med. 1999;189:831 41. 72. Su M A, Trenor CC, Fleming JC, Fleming MD, Andrews NC. The G185R mutation disrupts function of the iron transporter Nramp2. Blood. 1998;92:2157 63. 73. Trinder ...
High affinity copper uptake protein 1
allele distribution of the SLC31A1 was not different between group N and O, and out of the 11 SNPs of the SLC22A2 gene only the allele distribution of the nonsynonymous SNP was significantly different between patients who experienced ...
Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis
Background: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1 ...
Unusual Ammonium Transporters - Transport across and into membranes
Ammonium transport (Amt) proteins are ubiquitous integral membrane proteins that transport NH4+ across cell membranes. Amt proteins involved in the uptake of NH4+ as direct N-source for biosynthesis are present in prokaryotes, archaea and plants . In mammals, Rhesus proteins are the Amt homologs and their presence in erythrocyte, kidney and liver cell membranes can be directly related to NH3/NH4+ detoxification and pH homeostasis processes . Long recognized for their immunogenic characteristics and involvement in hemolytic diseases of infants, a number of genetic diseases have been associated with the inability to correctly express Rh proteins [2,3]. Understanding the molecular details of transport and regulation of Amt proteins is therefore highly relevant to help treat and solve many human Rh-related diseases.. A significant amount of our research has focused on the archaea homologs, in particular on the Af-Amt1 protein from Archaeoglobus fulgidus. We have solved the crystal structures ...
Búsqueda | Portal Regional de la BVS
Background: Radiation therapy remains an important treatment modality in cancer therapy, however, resistance is a major problem for treatment failure. Elevated expression of glutathione is known to associate with radiation resistance. We used glutathione overexpressing small cell lung cancer cell lines, SR3A-13 and SR3A-14, established by transfection with Î³-glutamylcysteine synthetase (Î³-GCS) cDNA, as a model for investigating strategies of overcoming radiation resistance. These radiation-resistant cells exhibit upregulated human copper transporter 1 (hCtr1), which also transports cisplatin. This study was initiated to investigate the effect and the underlying mechanism of iron-platinum nanoparticles (FePt NPs) on radiation sensitization in cancer cells. Materials and Methods: Uptakes of FePt NPs in these cells were studied by plasma optical emission spectrometry and transmission electron microscopy. Effects of the combination of FePt NPs and ionizing radiation were investigated by colony ...
Anti-SLC11A1 Antibody (HPA029590) - Atlas Antibodies
Rabbit Polyclonal Anti-SLC11A1 Antibody against Human solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1. Validated for Immunohistochemistry
Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid...
The daily production of 200 billion erythrocytes requires 20 mg of iron, accounting for nearly 80% of the iron demand in humans. Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface. The Tf:TfR complex then enters the endosome via receptor-mediated endocytosis. Upon endosomal acidification, iron is released from Tf, reduced to Fe²⁺ by Steap3, and transported across the endosomal membrane by divalent metal ion transporter 1. Steap3 is comprised of an N-terminal cytosolic oxidoreductase domain and a C-terminal heme-containing transmembrane domain. The NADPH/flavin binding domain of Steap3 differs significantly from those in other eukaryotic reductases. Steap3 shows remarkable, although limited homology to FNO, an archaeal oxidoreductase. We have determined the crystal structure of the human-Steap3 oxidoreductase domain in the absence and presence of NADPH (PDB-ID 2vns and ...
ZIP13 Antibody | Abbiotec
The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways ...
Role of proteolysis in copper homoeostasis | Biochemical Society Transactions
The cop operon of Enterococcus hirae controls cytoplasmic copper levels. It encodes two copper ATPases, a repressor, and the CopZ metallo-chaperone. Transcription of these genes is induced by copper. However, at higher copper concentrations, CopZ is degraded by a copper-activated proteolytic activity. This specific proteolysis of CopZ can also be demonstrated in vitro with E. hirae extracts. Growth of the cells in copper increases the copper-inducible proteolytic activity in extracts. Zymography reveals the presence of a copper-dependent protease in crude cell lysates. Copper-stimulated proteolysis of CopZ appears to play an important role in copper homoeostasis by E. hirae. ...
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases. - Nuffield Department of Medicine
AIMS/HYPOTHESIS: Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are associated with ZnT8A. METHODS: The levels of ZnT8A were measured in 2,239 British type 1 diabetic individuals diagnosed before age 17 years, with a median duration of diabetes of 4 years. Cases were tested at over 775,000 loci genome wide (including 53 type 1 diabetes associated regions) for association with positivity for ZnT8A. ZnT8A were also measured in an independent dataset of 855 family members with type 1 diabetes. RESULTS: Only FCRL3 on chromosome 1q23.1 and the HLA class I region were associated with positivity for ZnT8A. rs7522061T|C was the most associated single nucleotide polymorphism (SNP) in the FCRL3 region (p = 1.13 × 10(-16)). The association was confirmed in the family dataset (p ≤ 9.20 × 10(-4)). rs9258750A|G was the most
Ferroportin and iron export from the macrophage
Species, Publications, Genomes and Genes, Research Topics, Scientific Experts about Ferroportin and iron export from the macrophage
Best Wilson Disease Clinic in Mumbai, India - Kokilaben Hospital
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TMEM163 Rabbit Polyclonal Antibody (ER1901-87) - HUABIO
Previously, it was shown that purified rodent Tmem163 protein reconstituted in liposomes forms a dimer and transports zinc in a proton-dependent manner. It was also shown that Tmem163s ability to bind and transport zinc becomes inactivated upon alanine substitution of two species-conserved aspartate residues at positions 123 and 127. Thus, the data indicate that these double aspartate residues are zinc binding sites, but that they do not affect Tmem163 dimerization. Note, however, that this particular study did not address the question of whether the protein serves to transport zinc in or out of living cells. TMEM163 may play a crucial role in cellular zinc homeostasis by extruding cytoplasmic zinc ions to the extracellular environment. Noteworthy is that TMEM163 is unique in that it has a short C-terminus region, whereas the human ZNT family of efflux transporters have typically long C-terminus regions. Despite such structural difference, data from both functional and phylogenetic studies of ...
TCDB » SEARCH
Homodimeric solute carrier family 30 (zinc transporter), member 8, ZnT8 or ZnT-8. An inherited R325W mutant gives aberant zinc transport in pancreatic beta cells (Weijers 2010). It is chiefly expressed in pancreatic islet cells, where it mediates zinc (Zn2+) uptake into secretory granules. It plays a role in glucose tolerance (Mitchell et al. 2016). ZnT8 is one of four human vesicular zinc transporters. It supplies millimolar zinc concentrations to insulin granules in pancreatic beta-cells, affecting insulin processing, crystallisation, and secretion. ZnT8 has a transmembrane and a C-terminal cytosolic domain; the latter has important functions and purportedly mediates protein-protein interactions, senses cytosolic zinc, and channels zinc to the transport site in the transmembrane domain (Parsons et al. 2018). The variant, W325R, in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes. The CTDs of the WT and mutant ...
As one of the essential macronutrients, potassium (K) plays crucial roles in plant development and growth by regulating cell electroneutrality, membrane potential, osmolality, and enzyme activity (Clarkson and Hanson, 1980; Leigh and Wyn Jones, 1984). K is present in plant cells in the cation (K+) form, the concentration of which is approximately 100 mm in the cytoplasm and even higher in vacuoles. However, available free K+ for plants is limited in soils, and the concentration is typically within the micromolar range (Schroeder et al., 1994; Maathuis, 2009). Therefore, plants evolved mechanisms to adapt to a suboptimal availability of K, including morphological and physiological alterations (Schachtman and Shin, 2007; Wang and Wu, 2013).. Under limited K+ conditions (below 0.5 mm), plants absorb K+ through high-affinity K+ transporters as well as some K+ channels (Epstein et al., 1963; Maathuis and Sanders, 1997; Véry et al., 2014). In Arabidopsis (Arabidopsis thaliana), the high-affinity K+ ...
Structural Biology of Copper Homeostasis - Vinzenz Unger
Genetic and biochemical studies lend strong support to the idea that the CTR-family of membrane proteins mediate cellular copper uptake. Similarly, the roles of...
Slc30a4 MGI Mouse Gene Detail - MGI:1345282 - solute carrier family 30 (zinc transporter), member 4
View mouse Slc30a4 Chr2:122523153-122544583 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Wilson Disease | Grand Strand Health
Learn more about Wilson Disease at Grand Strand Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Selain Ingatkan Netralitas di Pilkada 2020, Kata Cellica, ASN Tetap Punya Hak Pilih. Lantas? | TAKtik
KARAWANG, TAKtik - Saat meminta Aparatur Sipil Negara (ASN) di lingkungan Pemkab Karawang menjaga netralitasnya di Pilkada 2020, Bupati Cellica Nurrachadiana juga mengatakan, ASN sebagai warga Negara tetap memiliki hak pilih.. Itu disampaikan Cellica di hadapan ribuan aparaturnya saat kegiatan Pembinaan Manajemen ASN Pemkab Karawang di Sport Hall Adiarsa, Rabu pagi (11/12/2019). Dikemukakannya, hak individu bagi setiap ASN dilindungi Undang-undang. Mereka bebas menentukan pilihan sesuai hati nurani masing-masing.. Dalam konteks netralitas, ASN sebagai abdi Negara, Cellica harapkan, agar tetap fokus melayani masyarakat. Tidak boleh terlibat dalam dukung mendukung pasangan calon bupati-wakil bupati manapun. ASN jangan terseret retorika politik, seperti ikut menyuarakan dukungan terhadap pasangan calon tertentu, tandasnya.. Menyinggung kegiatan Pembinaan Manajemen ASN di pemerintahannya, Cellica ingatkan mereka agar menyelesaikan program pembangunan sebagaimana target RPJMD (Rencana Pembangunan ...
5ah3 » Ammonium transporter MEP2, structure 2 - Orientations of Proteins in Membranes (OPM) database
A - Tilt: 7° - Segments: 1( 29- 49), 2( 61- 86), 3( 116- 138), 4( 144- 166), 5( 184- 201), 6( 223- 244), 7( 251- 275), 8( 283- 305), 9( 306- 324), 10( 336- 357), 11( 378- 406 ...
DI-fusion Screening for insulinoma antigen 2 and zinc transporter 8...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
CLF announces free workshops on Art and Craft for Wilson Disease patients | Childrens Liver Foundation
Disclaimer: The information contained in this site is intended for general reference purposes only. It is not a substitute for professional medical advice or a medical exam. Always seek the advice of your physician or other qualified health professional before starting any new treatment ...
Protocols and Video Articles Authored by Sang Hak Lee (Translated to French)
Sang Hak Lee is the author of this article in the Journal of Visualized Experiments: Limagerie de fluorescence avec un nanomètre Précision (FIONA)
Search of: Wilson Disease - List Results - ClinicalTrials.gov
Cytokine and laboratory values will be compared to baseline to test the hypothesis that TM will affect the level of TNF alpha, IL-1, C-protein, and TGF ...
The Wilson Disease Association (WDA) is a volunteer organization striving to promote the well being of patients with Wilson disease and their families and friends. WDA Conference
Who Has Patrick Wilson Dated? | His Dating History with Photos
Who is Patrick Wilson dating? Many famous women have dated Patrick Wilson, and this list will give you more details about these lucky ladies. Including ...
Articles about Wilson Betemit - tribunedigital-baltimoresun
Wilson Betemit News. Find breaking news, commentary, and archival information about Wilson Betemit From The tribunedigital-baltimoresun
Wilson in a Word
Wilson in a Word Resourceful is what comes to mind for Shahida Afrin. With its technology-rich labs and fashion studio, students can think and do as… The post Shahida Afrin - Resourceful appeared first on Wilson College News. ...
Neuromuscular Stimulator Therapy - Neuromuscular Stimulator Therapy Exporter, Importer & Manufacturer, Chennai, India
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Domain has Development Sites for Sale in Wilson, WA, 6107 & surrounding suburbs. View our listings & use our detailed filters to find your perfect home.
Gene Expression: Buzsaki and Wilson
For the die-hards. I taped the Buzsaki and Wilson lectures at the Visualizing and Recording Large-Scale Ensembles short course at SFN. Quality isnt really great and a lot of it doesnt make sense without the slides, but, hey, its there if you want it ...
Wilson Alobuias Profile | Stanford Profiles
Wilson Alobuia is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.
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Organic cation transport protein
An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are ... This family of proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier ... proteins than the organic anion transporters. (Solute carrier family, Transmembrane transporters, Transport proteins). ...
One transport protein or many?". Pharmacology & Therapeutics. 239: 108283. doi:10.1016/j.pharmthera.2022.108283. PMID 36162727 ... Cocaine crosses the blood-brain barrier via a proton-coupled organic cation antiporter and (to a lesser extent) via passive ... Cocaine crosses the blood-brain barrier via both a proton-coupled organic cation antiporter and (to a lesser extent) via ... It also functions on the binding sites to the dopamine and serotonin sodium dependent transport area as targets as separate ...
K. muelleri" makes include a couple of transport proteins; the microbe creates organic cation transport proteins, antibiotic- ... Of the 227 different polypeptides, 99 of them are enzymes and another 9 are transport proteins. The GC-content is 22.4%. A ... The tree was constructed by comparing the peptide sequences of ten different types of proteins. The proteins used were the DNA ... 21.3% of its protein-coding genes are dedicated to creating amino acids, while another 33% is dedicated to translation-related ...
... transporting one sodium ion with one molecule of carnitine. Organic cations transported by this protein include ... SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active ... an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine ... The SLC22A5 gene codes for a plasma integral membrane protein which functions as both an organic cation transporter and a ...
Organic cation transport proteins Organic anion-transporting polypeptide Solute carrier family Osmoregulation Organic anion ... Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane proteins). ... The generalized transport reaction catalyzed by OSTα/OSTβ is: organic anion (out) ⇌ organic anion (in) Each transport system ... The two proteins are highly expressed in many human tissues. The β-subunit is not required to target the α-subunit to the ...
... or a transport protein. It also serves as an important regulator in a variety of surface proteins, both on the cell surface and ... Putrescine serves an important role in a multitude of ways, which include: a cation substitute, an osmolyte, ...
Some examples of proteins that mediate this process are glucose transporters, organic cation transport proteins, urea ... The carrier protein at the membrane binds to the glucose and alters its shape such that it can easily to be transported. ... the transport relies on molecular binding between the cargo and the membrane-embedded channel or carrier protein. the rate of ... Their transport must therefore be "facilitated" by proteins that span the membrane and provide an alternative route or bypass ...
Solute carrier family Organic cation transport proteins GRCh38: Ensembl release 89: ENSG00000175003 - Ensembl, May 2017 GRCm38 ... This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains ... Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1. Polyspecific organic cation ... "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". The Journal of Biological ...
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic ... Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene. ... "ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene & protein". www.uniprot.org. ... 2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol ...
... the ANDI/netCDF scientific data interchange file format Cation diffusion facilitator, transport protein Channel Definition ...
... or OCT may refer to: Optical coherence tomography, an imaging method Organic cation transport protein, a type of protein ...
... sodium-independent organic cation transport proteins (OCTs) and/or carnitine/organic cation transporters (OCTNs), and do not ... Choline kinase (CK) is a cytosolic protein that catalyzes the following reaction:: 418 choline + ATP ⇌ phosphocholine + ADP In ... Michel V, Yuan Z, Ramsubir S, Bakovic M (May 2006). "Choline transport for phospholipid synthesis". Experimental Biology and ... which include the choline transporter-like protein 1 (CTL1). The fate of internalized choline depends on the cell type. In pre- ...
... altering cellular functions and ultimately influencing cation transport through the plasma membrane and stimulating the proton ... Metabolic: protein catabolism which causes negative nitrogen balance. Musculoskeletal: muscle weakness, loss of muscle mass, ... The metabolic effects of taking methylprednisolone involve the continuous breakdown of proteins for gluconeogenesis increase ... This association changes physiochemical properties of the membrane; activating membrane proteins, ...
... a molecule that transports a single potassium cation. Carrier ionophores may be proteins or other molecules. Channel formers ... Gräfe, U.; Reinhardt, G.; Miosga, N. (1989). "Monovalent cation specificity of passive transport mediated by laidlomycin and 26 ... Ionophores facilitate the transport of ions across biological membranes most commonly via passive transport, which is affected ... Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport ...
... of transport proteins includes members that function as solute:cation symporters and solute:solute antiporters. They occur in ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... The larger eukaryotic and archaeal proteins possess N- and C-terminal hydrophilic extensions. Some animal proteins, for example ... APC Superfamily Transporter Classification Database Membrane transport protein Saier MH (August 2000). "Families of ...
"The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE. 10 (10): e0137184. Bibcode: ... Note that this family differs from the calcium:cation antiporter (CaCA) family which belongs to the cation diffusion ... Portal: Biology v t e (Protein families, Solute carrier family, All stub articles, Membrane protein stubs). ... CaCA2 family proteins are found in bacteria, archaea, yeast, plants and animals. This family, previously called the ...
Bacterial potassium transporter
TrkH from Escherichia coli is a transmembrane protein and determines the specificity and kinetics of cation transport by the ... This protein family consists of various potassium transport proteins (Trk) and V-type sodium ATP synthase subunit J or ... This protein interacts with TrkA and requires TrkE for transport activity. Schlosser A, Meldorf M, Stumpe S, Bakker EP, Epstein ... determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli". J. Bacteriol. 177 (7): 1908- ...
... escort protein, acid transport protein, cation transport protein, or anion transport protein) is a protein that serves the ... A membrane transport protein (or simply transporter) is a membrane protein that acts as such a carrier. A vesicular transport ... Membrane+transport+proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Vesicular+Transport+Proteins ... There are several different kinds of transport proteins. Carrier proteins are proteins involved in the movement of ions, small ...
Monovalent cation:proton antiporter-1
Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC# 2.A.36) is a large family of proteins derived from Gram-positive ... M4 and M9 therefore contain critical sites for both drug and cation recognition. The generalized transport reaction catalyzed ... The bacterial proteins have 520-550 amino acyl residues (aas) while eukaryotic proteins are generally larger, varying in size ...
Epithelial sodium channel
The generalized transport reaction for Na+ channels is: Na+ (out) → Na+ (in) That for the degenerins is: Cation (out) → cation ... CFTR is a transmembrane channel responsible for chloride transport and defects in this protein cause cystic fibrosis, partly ... "ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family". Functional and Phylogenetic Classification of Membrane Transport ... Toczyłowska-Mamińska R, Dołowy K (February 2012). "Ion transporting proteins of human bronchial epithelium". Journal of ...
Nucleobase cation symporter-1
Protein families, Protein domains, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, ... The Nucleobase:Cation Symporter-1 (NCS1) Family (TC# 2.A.39) consists of over 1000 currently sequenced proteins derived from ... providing the structural basis of the alternating access model for membrane transport. NCS1 proteins are H+/Na+ symporters ... The latter three proteins are likely to be closely related thiamin permease isoforms. The yeast cytosine-purine and vitamin B6 ...
The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to ... This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the ... Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene. ... "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of ...
Phospholipid-transporting ATPase VA
The protein encoded by ATP10A belongs to the family of P-type cation transport ATPases, and to the subfamily of ... "ATP10A - Phospholipid-transporting ATPase VA - Homo sapiens (Human) - ATP10A gene & protein". www.uniprot.org. Retrieved 9 ... Phospholipid-transporting ATPase VA also known as ATPase class V type 10A or aminophospholipid translocase VA is an enzyme that ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31-9. doi ...
Multidrug and toxin extrusion protein 1
Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and ... 2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends Pharmacol. Sci. 27 ( ... 2006). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U ... Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans ...
The cation:proton antiporter (CPA) superfamily is a superfamily of transport proteins named after one of its constituent ... Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane proteins, Protein ... As of April 2016, the CPA superfamily consists of four members: Monovalent cation:proton antiporter-2 family Malonate:Sodium ... members, the monovalent cation:proton antiporter-2 (CPA2). CPA1 was considered a member of the superfamily until 2010, when it ...
... but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine ... The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), ... The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. ... and pH-dependent transport of organic cations". The Journal of Pharmacology and Experimental Therapeutics. 289 (2): 768-73. ...
... but the Ki for Mg2+ inhibition of this transport is currently unknown. The transport of other cations by the Alr1p protein was ... also showed that the protein could transport Zn2+ and Fe2+, but did not report on the capacity of the protein to transport ... The transport of Zn2+ by this protein may be as important as that of Mg2+. The table shows a comparison of the transport ... How the transport of Mg2+ by the protein is regulated was not determined. Currents were observed to pass through the protein in ...
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+- ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... Sodium/potassium-transporting ATPase subunit alpha-3 is an enzyme that in humans is encoded by the ATP1A3 gene. ... "Entrez Gene: ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide". Smith RS, Florio M, Akula SK, Neil JE, Wang Y, Hill RS, ...
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of ... The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to ... This gene encodes the member 3 of the phospholipid-transporting ATPase 8B. Alternatively spliced transcript variants encoding ... The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3. ...
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ - ... Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene. ... Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na ... These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules ...
The disulfide bond (-S-S-) plays a major role in the conformation of proteins and in the catalytic activity of enzymes. Sulfide ... 8 MgS + 8 I2 → S8 + 8 MgI2 Aqueous solutions of transition metals cations react with sulfide sources (H2S, NaHS, Na2S) to ... pipelines transporting soured oil, Kraft paper factories. Microbially-induced corrosion (MIC) or biogenic sulfide corrosion are ...
Voltage-gated ion channel
2004). "Phylogeny as a guide to structure and function of membrane transport proteins". Mol Membr Biol. 21 (3): 171-181. doi: ... polycystin cation channels, glutamate-gated ion channels, calcium-dependent chloride channels, monovalent cation:proton ... Phylogenetic studies of proteins expressed in bacteria revealed the existence of a superfamily of voltage-gated sodium channels ... Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the ...
... ions from the cell provides the driving force for several secondary active transporters such as membrane transport proteins, ... Skou JC (February 1957). "The influence of some cations on an adenosine triphosphatase from peripheral nerves". Biochimica et ... Protein-protein interactions play a very important role in Na⁺-K⁺ pump-mediated signal transduction. For example, the Na⁺-K⁺ ... this membrane protein can also relay extracellular ouabain-binding signalling into the cell through regulation of protein ...
Plasma membrane monoamine transporter
This protein is an integral membrane protein that transports the monoamine neurotransmitters (serotonin, dopamine, ... Xia L, Zhou M, Kalhorn TF, Ho HT, Wang J (Jun 2009). "Podocyte-specific expression of organic cation transporter PMAT: ... as well being only weakly sensitive to the adenosine transport inhibitor, dipyridamole. Its transport of monoamines, unlike for ... The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by ...
It does this via two important transport proteins called hemoglobin and myoglobin. Hemoglobin in the blood transports oxygen ... Magnesium is the most abundant free cation in plant cytosol, is the central atom in chlorophyll and offers itself as a bridging ... Both proteins are tetramer complexes with iron protein complexes called hemes built into each subunit of the tetramer. The ... Processes including oxygen transport and DNA replication are carried out using enzymes such as DNA polymerase, which in humans ...
The WNK1 protein is composed of 2382 amino acids (molecular weight 230 kDa). The protein contains a kinase domain located ... CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell. WNK1 mutations as a ... The predominant role of WNK1 is the regulation of cation-Cl− cotransporters (CCCs) such as the sodium chloride cotransporter ( ... The gene belongs to a group of four related protein kinases (WNK1, WNK2, WNK3, WNK4). Homologs of this protein have been found ...
Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded ... 2005). "WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl− cotransporters required for normal blood ... This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the ... WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the ...
A notable example of the former is the farnesylation of small G-proteins including Ras, CDC42, Rho, and Rac. The attachment of ... Ubiquinone is a key electron carrier in the electron transport chain of cellular respiration. Isoprenoids are a large group of ... The loss of pyrophosphate forms dimethylallyl cation. In the second step, the reactive C3-C5 double bond in isopentyl ... Ericsson J, Jackson SM, Edwards PA (Oct 1996). "Synergistic binding of sterol regulatory element-binding protein and NF-Y to ...
Lipid bilayer fusion
The first of these proteins to be studied were the viral fusion proteins, which allow an enveloped virus to insert its genetic ... Exocytosis, fertilization of an egg by sperm and transport of waste products to the lysosome are a few of the many eukaryotic ... These studies have shown that divalent cations play a critical role in the fusion process by binding to negatively charged ... Even once the role of SNAREs or other specific proteins is illuminated, a unified understanding of fusion proteins is unlikely ...
Fresh and saltwater fish are the main source of protein for about one billion people and comprise 15% of an additional 3.5 ... Key factors that are assessed to determine water quality include: Major anion analysis: (HCO3−,Cl−,NO3−,SO42-) Major cation ... Sediment and heavy metal traps: Precipitation and surface runoff induces soil erosion, transporting sediment in suspension into ... billion people's protein intake. Another food staple found in wetland systems is rice, a popular grain that is consumed at the ...
For the extracellular polymeric substances, many proteins and other bio-macromolecules are required. Many metal cations are ... The extracellular electron transport chains responsible for transferring electrons across cell membranes are relatively well ... EDTA control and extensive cation presence/absence tests show that Ca(II), Mn(II), Cu(II) and Zn(II) are all essential in this ... Cytochrome c class protein SO3300 also has an elevated transcription. For example, when reducing U(VI), special cytochromes ...
Many of these proteins are located in a conserved gene cluster. Later (2013) studies have identified a few more enzymes that ... The main function of teichoic acids is to provide flexibility to the cell-wall by attracting cations such as calcium and ... Following the synthesis, the ATP-binding cassette transporters (teichoic-acid-transporting ATPase) TarGH (P42953, P42954) flip ...
GABA transporter type 1
I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport ... GABA transporter 1 (GAT1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is ... In this conformation, 2 extracellular Na+ ions are co-transported into the neuron along with 1 GABA and 1 Cl− that bind to the ... The presence of a Cl−/Cl− exchange is also proposed because the Cl− transported across the membrane does not affect the net ...
... and with many cations. Variations have been prepared including the incomplete cubanes [Fe3S4(SR)3]3−. The Rieske proteins ... Both are part of the electron transport chain of their respective organisms which is a crucial step in the energy harvesting ... The ferredoxin proteins are the most common Fe-S clusters in nature. They feature either 2Fe-2S or 4Fe-4S centers. They occur ... The relevant redox couple in all Fe-S proteins is Fe(II)/Fe(III). Many clusters have been synthesized in the laboratory with ...
Potential applications of graphene
Human serum albumin (HSA) is one of the most abundant blood proteins. It serves as a transport protein for several endogenous ... Its surface is covered with epoxy, hydroxyl, and carboxyl groups that interact with cations and anions. It is soluble in water ... "Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: ... By the next year, a commercial version of a graphene biosensor was being used by biology researchers as a protein binding ...
The main interaction mechanism is competition for plasma protein transport. In these cases the drug that arrives first binds ... Formation of non-absorbable complexes: Chelation: The presence of di- or trivalent cations can cause the chelation of certain ... Binding with proteins. Some drugs such as sucralfate binds to proteins, especially if they have a high bioavailability. For ... This transport system can also be saturated if the plasma concentrations of the drug are high. Bile excretion of drugs mainly ...
... which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the ... 2006). "The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor ... structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein ... The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae). ...
... which allows cells to regulate salt concentrations and pH by transporting ions across their membranes using proteins called ion ... The presence of ions, in particular divalent cations like magnesium and calcium, strongly affects this step. One of the ... Some of these proteins are linked to the exterior of the cell membrane. An example of this is the CD59 protein, which ... The most common class of this type of protein is the G protein-coupled receptor (GPCR). GPCRs are responsible for much of the ...
Protein ADP-ribosylation. Inhibition of protein arginine ADP-ribosylation. Matrix metalloproteases (MMPs). Indirect down- ... Agmatine binds to α2-adrenergic receptor and imidazoline receptor binding sites, and blocks NMDA receptors and other cation ... Agmatine is a precursor for polyamine synthesis, competitive inhibitor of polyamine transport, inducer of spermidine/spermine ... Marc RE (April 1999). "Mapping glutamatergic drive in the vertebrate retina with a channel-permeant organic cation". The ...
... a soluble protein found in the mitochondrial electron transport chain, where it probably protects against toxic peroxides; ... is oxidized to the porphyrin pi-cation radical (R'). Compound I then oxidizes an organic substrate to give a substrate radical ... Protein pages needing a picture, Protein domains, EC 1.11.1, Hemoproteins). ... Class II proteins contain four conserved disulphide bridges and two conserved calcium-binding sites. Class III consists of the ...
Probable cation-transporting ATPase 13A3 is an enzyme that in humans is encoded by the ATP13A3 gene. GRCh38: Ensembl release 89 ... "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins ...
... is a transport protein in the plasma membrane of cells that serves to remove calcium (Ca2+) from the cell. It is vital for ... EC 18.104.22.168 Overview at utoronto.ca Cation transporting ATPase family in Pfam Portal: Biology (Articles with short description ... Short description matches Wikidata, Transport proteins, Transmembrane proteins, EC 7.2.2). ... Active transport#Counter-transport PDB Molecule of the Month Calcium pump nlm.nih.gov Jensen TP, Buckby LE, Empson RM ( ...
Jared Diamond bibliography
Diamond, J. M. (1996). "Wet transport proteins". Nature. 384 (6610): 611-612. Bibcode:1996Natur.384..611D. doi:10.1038/384611a0 ... Moreno, J. H.; Diamond, J. M. (1974). "Role of hydrogen bonding in organic cation discrimination by gallbladder epithelium". ... Karasov, W. H.; Pond III, R. S.; Solberg, D. H.; Diamond, J. M. (1983). "Regulation of proline and glucose transport in mouse ... Diamond, J. M. (1964). "The Mechanism of Isotonic Water Transport", The Journal of General Physiology. 48: 15-42 . doi:10.1085. ...
Period 2 element
Nitrogen is a constituent element of amino acids and thus of proteins, and of nucleic acids (DNA and RNA). It resides in the ... In ionic compounds, lithium loses an electron to become positively charged, forming the cation Li+. Lithium is the first alkali ... Fluorine even attacks silica, one of the favored materials for transporting strong acids, and burns asbestos. It attacks common ... The sugars are then turned into such substances as cellulose and (with nitrogen and often sulfur) proteins and other essential ...
Depending on their charge, proteins are associated with a variety of smaller anions and cations. In plant cells, the anion ... Ion permeation through hydrophobic cell walls is mediated by ion transport channels. Nucleic acids are anionic, the ... Solubility of salts in organic solvents is a function of both the cation and the anion. The solubility of cations in organic ... Similarly, the solubility of anions in organic solvents is enhanced with lipophilic cations. The most common lipophilic cations ...
The Bacillus protein exports both arsenite and antimonite. The exact transport mechanism has not established. The generalized ... Ramos, J; Ariño, J; Sychrová, H (April 2011). "Alkali-metal-cation influx and efflux systems in nonconventional yeast species ... These proteins are the ACR3 protein of Saccharomyces cerevisiae, also called the ARR3 protein, and the 'ArsB' protein of ... In the latter case ATP hydrolysis again energizes transport. ARC3 homologues transport the same anions as ArsA/AB homologues, ...
... anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior". Proceedings of the National Academy of ... A major event in the budding of vesicles, such as transport carriers from the Golgi, is the creation and subsequent narrowing ... The interconversion of lysoPA, PA, and DAG - and changes in pH and cation concentration - can cause membrane bending and ... The roles of lysoPA, PA, and DAG in promoting membrane curvature do not preclude a role in recruiting proteins to the membrane ...
... is known for its ability to form complexes with alkali cations, most notably potassium and sodium. In general, ... This is how nonactin is able to transport potassium ions across lipid membranes. Nonactin has been reported to specifically ... inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. It is able to uncouple the oxidative ... Although nonactin (and all nactins) exhibits an especially high cation selectivity for potassium ions over sodium ions or ...
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the ... Cation Transport Proteins * Cations * Ion Channels * TRPV Cation Channels * Trpv4 protein, mouse ... OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity Nat Cell Biol. 2000 Oct;2(10):695- ... Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the ...
TRPM1 gene: MedlinePlus Genetics
The TRPM1 gene provides instructions for making a protein called transient receptor potential cation channel subfamily M member ... This protein acts as a channel, transporting positively charged atoms (cations) into cells. The TRPM1 channel is found on the ... The TRPM1 gene provides instructions for making a protein called transient receptor potential cation channel subfamily M member ... In bright-light conditions, the TRPM1 channel is open, allowing cations to flow in and out of bipolar cells and preventing ...
Bacterial physiological adaptations to contrasting edaphic conditions identified using landscape scale metagenomics<...
Cation Transport Proteins Medicine & Life Sciences 8% * Biodiversity Medicine & Life Sciences 6% ... Assessment of indicator genes revealed that the acidic organic-rich soils possessed a greater abundance of cation efflux pumps ... Assessment of indicator genes revealed that the acidic organic-rich soils possessed a greater abundance of cation efflux pumps ... Assessment of indicator genes revealed that the acidic organic-rich soils possessed a greater abundance of cation efflux pumps ...
SCOPe 2.08: Domain d1wpgb1: 1wpg B:125-239
Family b.82.7.1: Metal cation-transporting ATPase, actuator domain A  (2 proteins). ... Superfamily b.82.7: Metal cation-transporting ATPase, actuator domain A  (1 family) a distorted variant of double-helix ... Other proteins in same PDB: d1wpga2, d1wpga3, d1wpga4, d1wpgb2, d1wpgb3, d1wpgb4, d1wpgc2, d1wpgc3, d1wpgc4, d1wpgd2, d1wpgd3, ... Class b: All beta proteins  (180 folds). *. Fold b.82: Double-stranded beta-helix  (7 superfamilies). one turn of ...
NIOSHTIC-2 Search Results - Full View
... membrane cation transport, calcium binding proteins, and enzymes ranging from phosphodiesterase to protein kinase C. Despite ... 808 individual proteins were resolved, 162 of which had coefficients of variation < .00 1) by the lead exposures studied. ... was to determine if low-level exposure of rabbits to lead would produce concentration-dependent changes in myocardial proteins ...
anti-CATSPER3 Antikörper (AA 201-300) (Alexa Fluor 350) | Produkt Nr. ABIN1692968
CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the ... cav-like protein, one-repeat calcium channel-like protein, CATSPER3, CACRC, Cav-like protein, CACRC, Cation channel, sperm ... Synonyms: cation channel sperm-associated protein 3, calcium channel repeat containing 1, putative ion channel CatSper3, ... CATSPER3, CACRC, 4921522D01Rik, cation channel sperm associated 3, cation channel, sperm associated 3, CATSPER3, Catsper3 ...
Sol Genomics Network
Cation efflux protein. - Biological Process: cation transport (GO:0006812). - Molecular Function: cation transporter activity ( ... Protein prediction analysis (2) Protein prediction analysis (2) Prediction based on longest six frame method >SGN-P151475 (180 ... Urease accessory protein UreG. - Biological Process: protein complex assembly (GO:0006461). - Molecular Function: nickel ion ... Urease accessory protein UreG. - Biological Process: protein complex assembly (GO:0006461). - Molecular Function: nickel ion ...
2022 Annual Meeting
Divalent cation driven liquid-liquid phase separation of disordered acidic proteins. Joshua E. Mayfield, University of ... Regulation of mitochondrial calcium transport by caloric restriction in rat kidney. Julian Cualcialpud Serna, Universidade de ... Protein Interest Group - Membrane proteins Organizers: Matthias Buck, Case Western University, and Fran Barrera, University of ... Nonstructural protein 1 of SARS coronavirus interacts with stress granule protein G3BP1 and accumulates in the stress granule ...
Drug Interactions with Antiretroviral Therapy (ART): Overview, Drug Interactions by Antiretroviral Class
Several other drug transport proteins have been discovered, and families of these proteins include multidrug and toxin ... Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and ... Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update. AAPS J. 2015 Jan. 17 (1):65-82. [QxMD ... 15] , organic anion transporter, breast cancer resistance protein  , and organic anion transporting polypeptide (OATP) ...
ESKAPEing the labyrinth of antibacterial discovery | Nature Reviews Drug Discovery
Identification of a cation transport pathway in Neisseria meningitidis PorB. Proteins 81, 830-840 (2013). ... Atomic-level characterization of the structural dynamics of proteins. Science 330, 341-346 (2010). This paper describes a ... including the kinetics of protein folding to the native state, in addition to the detail these methods provide at atomic ... The authors also demonstrate the selective binding and transport of antibiotics by these channels. ...
Cation Transport Proteins - Preferred Concept UI. M0380835. Scope note. Membrane proteins whose primary function is to ... 2002; for CATION PUMPS & CATION PUMP see ION PUMPS 1992-2001. History Note:. 2002; for CATION PUMPS & CATION PUMP use ION PUMPS ... Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a ... facilitate the transport of positively charged molecules (cations) across a biological membrane. ...
Table 3 | Characteristics of differentially expressed proteins..
Characteristics of differentially expressed proteins identified by 45Ca- 760 autoradiography ... Protein class. 7816/6807. 63.6/87.4. * 2.11; 2.41. ↓10mMCa. ↑Bapta 0.5mM. 45Ca. Probable Cation transport ATPase 92% coverage. ... Protein expression. change Ca. Protein expression. change BAPTA/. EGTA. Detected by. LC/MS ID. Gene name. ... Heat-shock protein 99% coverage. grpE. Class I. 9102/9103. 19.99/23.52. *2.5; 2.5. ↓5mMCa. ↑0.25 Bapta. ↑0.5mM Bapta. 45Ca. ...
Arielle Lyon Langer, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
IMSEAR at SEARO: Search
... "protein_coding" "AAC74302","chaC","Escherichia coli","cation transport regulator [Ensembl]. ChaC-like protein [Interproscan ... "mercuric transport protein [Ensembl].","protein_coding" "AGT26737","N559_5163","Klebsiella pneumoniae","hypothetical protein [ ... "sn-glycerol 3-phosphate transport protein [Ensembl]. Bacterial extracellular solute-binding protein [Interproscan].","protein_ ... "protein_coding" "AAL20685","STM1770","Salmonella enterica","cation transport regulator [Ensembl]. ChaB [Interproscan]."," ...
Cells | Free Full-Text | Associations between Pregnane X Receptor and Breast Cancer Growth and Progression
Because PXR is important for the uptake and efflux of steroid hormones and metabolites due to the variety of transport proteins ... and organic cation transporter 1 (Oct1) [20,21,22]. Multi-drug resistance-associated protein 2 (MRP2) and MRP3, both of which ... Pondugula, S.R.; Dong, H.; Chen, T. Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. Expert ... expression of hepatic uptake drug and bile acid transporter proteins including organic anion transporting polypeptide protein 2 ...
ATP7B - hpluswiki
Cation Transport Proteins. *Circadian Rhythm. *Copper. *Copper-Transporting ATPases. *Cyclic AMP. *Photoreceptor Cells, ... Copper-transporting ATPase 2 (EC 22.214.171.124) (Copper pump 2) (Wilson disease-associated protein) [Contains: WND/140 kDa] [PWD] [ ... ATP7A, ATP7B and CTR1 are metal transporting proteins that control the cellular disposition of copper and platinum drugs, but ... PINA is able to restore copper transport activity in Saccharomyces cerevisiae deficient in the homologous copper-transporting ...
Citations Library | PerkinElmer
Animals; Antibodies, Bacterial; Antigens, Bacterial; Bioware; Cation Transport Proteins; Disease Models, Animal; Female; Humans ... Amino Acid Transport Systems, Neutral; Animals; Bacterial Proteins; Bioware; Blotting, Northern; Disease Models, Animal; Gene ... Multifunctional Role of Choline Binding Protein G in Pneumococcal Pathogenesis. Year: 2006. Publication: Infection and Immunity ... Proteomics-based identification of anchorless cell wall proteins as vaccine candidates against Staphylococcus aureus. Year: ...
NWMN RS04995 - AureoWiki
Metabolism Transport and binding proteins Cations and iron carrying compounds potassium uptake protein, Trk family (TIGR00934; ... Metabolism Transport and binding proteins Cations and iron carrying compounds potassium uptake protein, TrkH family (TIGR00933 ... Protein[edit , edit source]. ⊟General[edit , edit source]. *locus tag: NWMN_RS04995 [old locus tag: NWMN_0893 ] ... Protein synthesis (provided by Aureolib)[edit , edit source]. *Aureolib: no data available ...
ATP8B3 ATPase phospholipid transporting 8B3 [Homo sapiens (human)] - Gene - NCBI
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of ... Cation_ATPase; Cation transport ATPase (P-type). pfam16209. Location:55 → 131. PhoLip_ATPase_N; Phospholipid-translocating ... Cation_ATPase; Cation transport ATPase (P-type). pfam16209. Location:108 → 184. PhoLip_ATPase_N; Phospholipid-translocating ... General protein information Go to the top of the page Help Preferred Names. phospholipid-transporting ATPase IK. Names. ATPase ...
MH DELETED MN ADDED MN
Organic Anion Transport Protein 1 D12.776.157.530.937.610 D12.776.543.585.937.719 Organic Cation Transporter 1 D12.776.157.530. ... Protein Transport G3.495.166.700 G3.143.700 Protein Unfolding G126.96.36.1990.750 G1.154.651.750 G1.595.100.640.750 G2.111. ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ... PrP 27-30 Protein D12.776.785.700.700 D12.776.785.340.750.700 PrPC Proteins D12.776.785.680 D12.776.785.340.500 PrPSc Proteins ...
Pesquisa | Prevenção e Controle de Câncer
Cation transport regulator-like protein 1 (CHAC1) was the most highly TMZ-upregulated gene. Overexpression and knockdown of ... Vitamin D-binding protein (DBP) was revealed to be upregulated in EOC ascites in our previous proteomic study. Here, we ... Vitamin D-Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt ... TMZ also induced CHAC1 to bind to the Notch3 protein and inhibit Notch3 activation, resulting in attenuation of Notch3-mediated ...
Frontiers | Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on...
ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1). The protein encoded by this gene belongs to the family of P-type cation ... The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into over 60 families (40). ... protein transcription activity and regulation, G-protein alpha subunit binding, and neuropeptide hormone activity. Enriched ... transport ATPases, and to the subfamily of Na+/K+ ATPases (38). Na+/K+ -ATPase is an integral membrane protein responsible for ...
YJR139C 267.488705 INESSENTIAL HOM6 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase),5-amino-6-(5...
... cation transport, molecular_function unknown, plasma membrane" YDR218C 8.87833 INESSENTIAL SPR28 "septin-related protein ... "Ammonia transport protein, transport," YLR348C 0.605291 INESSENTIAL DIC1 "mitochondrial dicarboxylate transport protein, ... "polyamine transport protein, transport," YDR019C 4.663699 INESSENTIAL GCV1 "glycine cleavage T protein (T subunit of glycine ... "metal resistance protein, similar to multidrug resistance proteins and cystic fibrosis protein CFTR, bilirubin transport*, ...
Zalatine : Uses, Side Effects, Interactions, Dosage / Pillintrip
Renal handling also involves tubular reabsorption, probably mediated by cation transport proteins. The renal elimination rate ... Renal handling also involves tubular reabsorption, probably mediated by cation transport proteins. The renal elimination rate ... Renal handling also involves tubular reabsorption, probably mediated by cation transport proteins. The renal elimination rate ... The mean volume of distribution of memantine is 9-11 L/kg and the plasma protein binding is low (45%). ...
SLC22A4 (NM 003059) Human Tagged ORF Clone - RC206575L2 | OriGene
... organic cation/ergothioneine transporter), member 4 (SLC22A4), mGFP tagged ... The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative ... Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]. ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ...
E - Biovědy | ResearchJobs.cz
PhD project1: Structure and function of proteins transporting alkali metal cations. The aim of this study is, with the use of ... Protein Structures. Proteinové struktury. PhD Project1: Study of allosteric communication in chimeric two-domain proteins upon ... transport a metabolismus serotoninu a tryptofanu v placentě, transport antidepresiv přes placentu z matky do plodu, vliv ... Role of CPEB protein in the female fertility. Why KO females for CPEB gene are sub-fertile?. Další info: v přiloženém PDF ...
TCDB » Superfamilies
Protein Kinase (PK) Superfamily. Protein kinase domains are sometimes found in transport proteins. These include TC#s 1.A.87.2. ... 8.A.82 - The Calmodulin Calcium Binding Protein (Calmodulin) Family. Cation Diffusion Facilitator (CDF) Superfamily. Paulsen, I ... The GTP-Binding Protein/GTPase Superfamily includes proteins from many multi-component transport systems, many of them involved ... These proteins usually have 4 - 6 TMSs and function in intracellular protein trafficking in eukaryotes and as protein chaparone ...
Genome-wide alternative splicing ... preview & related info | Mendeley
ATPaseDivalent cationTransportersOrganicMembrane cationPositively charged moleculesIntracellularCalciumPolyvalent cationsTransmembraneCellularRegulator-like proteinAtomsBacterialMoleculesAmino acidsCell membraneAnionClassifiReceptorsChannelsSubstancesPermeabilityCharacterization of transportBindsBioinformaticSubfamilyElectroneutralSodiumZincBindInsulinAntigensPathwayAntigenAntibodyMitochondrialKinaseMembranesMiceSolutesTransporter proteinSubunitNuclearSuperfamily
- protein_coding" "AAC73969","clpA","Escherichia coli","ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity [Ensembl]. (ntu.edu.sg)
- CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery. (nih.gov)
- These ATPase are found as coomponents of several protein secretion systems as well as synaptosomal fusion systems. (tcdb.org)
- The protein-protein interaction network analysis enriched two local network clusters namely cation transporting ATPase C-terminus and Sodium/potassium ATPase beta chain cluster, and mixed inclusion of Ion homeostasis and EF-hand domain cluster. (mendeley.com)
- Previous work suggested that CNIs reduce the abundance of key divalent cation transport proteins, expressed along the distal convoluted tubule, causing renal magnesium and calcium wasting. (elsevier.com)
- The ION Biosciences' Brilliant Calcium Assay is useful for a wide range of effectors of intracellular Ca²+ including many G protein-coupled receptors (GPCRs), divalent cation channels, and other proteins capable of transporting Ca²+ or affecting intracellular Ca²+ dynamics. (icocinfo.org)
- The essential functions of this divalent cation continue to be elucidated, particularly in head injury/stroke and cardiopulmonary disorders. (medscape.com)
- For instance, DTG decreases the renal clearance of metformin by inhibiting organic cation transporters in renal tubular cells. (medscape.com)
- Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. (origene.com)
- In the past 10 years, Solid Supported Membrane (SSM)-based electrophysiology has been proven as an efficient tool for the characterization of electrogenic membrane proteins, e.g. transporters, ion pumps and ion channels. (nanion.de)
- We analyzed different transport modes of the Na + /Ca 2+ exchanger NCX and assayed binding and transport reactions of different sugar transporters individually. (nanion.de)
- 7] Cation-Cl cotransporters are transmembrane proteins that include thiazide-sensitive Na-Cl co-transporter, loop diuretic-sensitive Na-K-2Cl co-transporters, and K-Cl co-transporters. (medscape.com)
- Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. (ox.ac.uk)
- Metformin, a substrate of several poly-specific organic cation transporters, is a widely used biguanide for the treatment of type II diabetes. (ox.ac.uk)
- Surprisingly, the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in renal tumours. (ox.ac.uk)
- These data suggest that the epigenetic suppression of the organic cation transporters in Tsc-associated mouse renal tumours may contribute to the lack of response to metformin treatment. (ox.ac.uk)
- An optimal solution for measuring intracellular Ca²+ dynamics, including effectors such as GPCRs and protein transporters. (icocinfo.org)
- Assessment of indicator genes revealed that the acidic organic-rich soils possessed a greater abundance of cation efflux pumps, C and N direct fixation systems, and fermentation pathways, indicating adaptations to both acidity and anaerobiosis. (elsevier.com)
- The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. (origene.com)
- The organic cation transporter OCT2 transports multiple substrates with different EC 50 and Vmax. (nanion.de)
- We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transporter 1 (OCT1) could increase the risk of severe gastrointestinal adverse effects. (dundee.ac.uk)
- Multidrug and toxin extrusion protein 1 (MATE1), which is encoded by solute carrier 47A1 ( SLC47A1 ), mediates the excretion of organic cations into bile and urine. (aspetjournals.org)
- Probably transports organic cations (By similarity). (cansar.ai)
- Mechanisms proposed for lead's effect on the cardiovascular system include alterations in adrenergic receptor density, membrane cation transport, calcium binding proteins, and enzymes ranging from phosphodiesterase to protein kinase C. Despite reported adverse effects, the cardiovascular toxicity of lead remains controversial due a significant number of negative studies. (cdc.gov)
- Abnormalities of red cell membrane cation permeability are seen in several hereditary disorders. (medscape.com)
- Any disturbances in membrane cation permeability alter cellular hydration and can cause numerous effects, including hemolysis. (medscape.com)
Positively charged molecules3
- Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane. (bvsalud.org)
- Most antagonistic reactions were between micronutrients such as Zn, copper (Cu), iron (Fe), calcium (Ca), and magnesium (Mg). These are all cations, or positively charged molecules or atoms. (vlsci.com)
- TRPM7 proteins help transport and regulate the stream of positively charged molecules in and out of the carotid bodies' cells. (news-medical.net)
- 8] "These membrane proteins are involved in several physiological activities including transepithelial ion absorption and secretion, cell volume regulation, and setting intracellular Cl concentration below or above its electrochemical potential equilibrium. (medscape.com)
- By transporting Na + and K + ions across the cell membrane, red cells can adjust the intracellular concentration of these cations and regulate intracellular hydration. (medscape.com)
- In contrast, the primary abnormality in DHSt is a change in the relative membrane permeability to K + . Efflux of K + is increased 2- to 4-fold and results in cation depletion, with decreased intracellular osmolality and water loss. (medscape.com)
- Here, we confirmed that tacrolimus-treated control mice developed hypomagnesemia and urinary calcium wasting, with decreased protein and mRNA abundance of key magnesium and calcium transport proteins (NCX-1 and Calbindin-D 28k ). (elsevier.com)
- These results indicate that tacrolimus affects calcium and magnesium transport along the distal convoluted tubule and strongly suggests that inhibition of the phosphatase, calcineurin, is directly involved. (elsevier.com)
- These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)
- Fifty percent of plasma calcium is ionized, 40% is bound to proteins (90% of which binds to albumin), and 10% circulates bound to anions (eg, phosphate, carbonate, citrate, lactate, sulfate). (medscape.com)
- At the cellular level, calcium is an important regulator of ion transport and membrane integrity. (medscape.com)
- Baloxavir may bind to polyvalent cations resulting in decreased absorption. (medscape.com)
- Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. (medscape.com)
- Aquaporins are transmembrane water permeable proteins involved in transcellular water flow. (adejournal.com)
- ATP7A , ATP7B and CTR1 are metal transporting proteins that control the cellular disposition of copper and platinum drugs, but their expression in dorsal root ganglion (DRG) tissue and their role in platinum-induced neurotoxicity are unknown. (transhumanist.ru)
- Chloride is mainly transported via electroneutral cation-Cl cotransporters, which allow Cl to always follow cations mainly Na and K across cellular membranes. (medscape.com)
- Early cellular responses to diverse growth stimuli independent of protein and RNA synthesis. (wikidata.org)
- Cation-proton antiporters are membrane-embedded transport proteins involved in a wide range of essential cellular processes, from controlling pH and salt concentration to osmoregulation of the cell volume. (cef-mc.de)
- Transport of positively charged hydrogen and sodium ions, called cations, create gradients that provide energy for diverse cellular processes, such as cell motility, import of nutrients, and extrusion of chemicals that are toxic to the cell. (pharmamicroresources.com)
- Because phosphorus is an essential element for DNA, RNA, several ubiquitous cofactors, and phosphorylated proteins, Pi-limitation has major affects on cellular metabolism and physiology. (biomedcentral.com)
- Cation transport regulator-like protein 1 (CHAC1) was the most highly TMZ-upregulated gene. (bvsalud.org)
- This protein acts as a channel, transporting positively charged atoms (cations) into cells. (medlineplus.gov)
- Cations and anions (negatively charged molecules or atoms) bind to different transport proteins. (vlsci.com)
- Transport proteins make up the active interface between the cell and the environment, and among the most important of these proteins are those which transport ions -- atoms or molecules with a net positive or negative electrical charge -- into and out of the cell, Barquera said. (pharmamicroresources.com)
- Bacterial extracellular solute-binding proteins [Interproscan]. (ntu.edu.sg)
- In the current project, "Control of Na+ and H+ transport in bacterial adaptation," researchers will seek to understand how transport proteins that move hydrogen and sodium cations through the cell membrane allow Pseudomonas to adjust its metabolism to different environmental conditions. (pharmamicroresources.com)
- The hybrid protein synthesized in the bacterial cell was penicillinase + pro-insulin from which insulin could be separated by trypsin. (biologydiscussion.com)
- Protein-bound molecules, including drugs, are eliminated by proximal tubular secretion via a well-coordinated process of uptake by the tubular cells at the blood-facing basolateral site and secretion into the tubular lumen. (springer.com)
- Most TRPM1 gene mutations change single protein building blocks (amino acids) in the TRPM1 channel and either alter the structure of the channel or prevent the channel from reaching the bipolar cell membrane. (medlineplus.gov)
- The APC superfamily consists of numerous families of porters that transport amino acids and their dereivatives. (tcdb.org)
- Red cells are characterized by cation leak of the red cell membrane, reflected in elevated sodium content, decreased potassium content, elevated MCHC and MCV, and decreased osmotic fragility. (unina.it)
- Metronidazole, being electron-affinic, can accept an electron from neutral free radical centres to generate a reactive cation that binds to an anion such as hydroxyl (OH-), causing a permanent lesion. (who.int)
- [ 7 ] At low temperatures, the defective anion channel appears to allow a significant cation leak, and autohemolysis may be seen in vitro at 4ºC. (medscape.com)
- These include Ca-Mg-HCO3, Mg-Ca-Cl, Na-Cl, and mixed waters in which neither a particular cation nor anion dominates. (researchgate.net)
- Classifi cation of the deleted ulcers ( 12 ). (cdc.gov)
- Megalin and cubilin receptors at the apical membrane are responsible for endocytosis-mediated reuptake of filtered low-molecular-weight proteins, such as β2-microglobulin (Eshbach and Weisz 2017 ). (springer.com)
- OTRPC4 forms Ca2+-permeable, nonselective cation channels that exhibit spontaneous activity in isotonic media and are rapidly activated by decreases in, and are inhibited by increases in, extracellular osmolarity. (nih.gov)
- Using silencing RNA, the researchers knocked out the gene responsible for the production of the TRPM7 channel protein, reducing the number of TRPM7 channels in the carotid bodies of obese mice. (news-medical.net)
- During glomerular filtration (Fig. 2 ), blood plasma is filtered in the glomerulus, a bundle of porous capillaries lined by a membrane and specialized epithelial cells, that allows solutes and waste, including drugs and their metabolites, and water to pass through while ensuring larger substances, such as blood cells and proteins, remain in the circulatory system (Holechek 2003 ). (springer.com)
- At one, five, 10 and 30 minutes, three paper points were removed from the contact substances, transported individually, immersed in 7 mL Letheen broth and incubated at 37°C for 48 hours. (bvsalud.org)
- Genetic defects of erythrocyte transport proteins cause disorders of red blood cell volume that are characterized by abnormal permeability to the cation and, consequently, by changes in red cell hydration. (unina.it)
Characterization of transport1
- Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. (tcdb.org)
- In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)
- Protein localization predicted from several bioinformatic algorithms. (proteinatlas.org)
- In this study, 107 types of human papillomavirus (HPV) L1 protein sequences were obtained from available databases, and the nuclear localization signals (NLSs) of these HPV L1 proteins were analyzed and predicted by bioinformatic analysis. (big.ac.cn)
- The TRPM1 gene provides instructions for making a protein called transient receptor potential cation channel subfamily M member 1 (TRPM1). (medlineplus.gov)
- The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. (nih.gov)
- structural biologists from the Max Planck Institute of Biophysics in Frankfurt succeeded in solving the structure of similar antiporters from microorganisms and then teamed up with theoretical biophysicists who unravelled the transport mechanism of this type of electroneutral transporter. (cef-mc.de)
- ION's Brilliant Sodium Assay is compatible with fluorescence microscopes, flow cytometers, and plate readers capable of detecting fluorescein or more optimally, yellow fluorescent protein (YFP). (icocinfo.org)
- ZIP (ZRT/IRT-like Protein) and CDF (Cation Diffusion Facilitator) are two large metal transporter families mainly transporting zinc into and out of the cytosol. (big.ac.cn)
- contains a zinc finger,XV" YOL091W 1 15 16 YOL091W "involved in sporulation,XV" YOL103W-B 1 15 17 YOL103W-B "TyB Gag-Pol protein. (davidson.edu)
- TMZ also induced CHAC1 to bind to the Notch3 protein and inhibit Notch3 activation, resulting in attenuation of Notch3-mediated downstream signaling pathways. (bvsalud.org)
- After the gene expression and the translation of mRNA into protein, the two polypeptides were cleaved from the enzyme and linked to form the complete insulin molecule. (biologydiscussion.com)
- The antigens are allowed to react with the serum and then precipitated using a special reagent such as PROTEIN A sepharose beads. (ucdenver.edu)
- Furthermore, the human disease-related salmonella infection pathway was significantly enriched in the protein-protein interaction network. (mendeley.com)
- Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). (wuxibiortus.com)
- The causative gene of this condition is ABCB6, encoding an erythrocyte membrane ABC transporter protein bearing the Langereis blood group antigen system. (unina.it)
- This hybrid plant can be utilized for large scale production of seeds containing antibody proteins. (biologydiscussion.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tubulin Polymerization Promoting Protein (TPPP) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tubulin Polymerization Promoting Protein (TPPP) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
- In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. (childrensmercy.org)
- Recent studies suggest that metformin attenuates mTORC1 signalling by the activation of 5' adenosine monophosphate-activated protein kinase (AMPK) in the presence or absence of a functional hamartin/tuberin (TSC1/TSC2) complex. (ox.ac.uk)
- It's a label-free, high-sensitivity method which allows the use of membrane preparations, e.g. reconstituted protein samples and membranes from native tissues or cell culture. (nanion.de)
- The mosaic mutation (Atp7a(mo-ms)) linked to X-chromosome is caused by changes in the Atp7a gene encoding CPx-type protein responsible for the ATP-dependent copper transport across cell membranes. (nel.edu)
- In a new study with obese mice, Johns Hopkins Medicine researchers say they have added to evidence that specialized channel proteins are possible therapeutic targets for sleep apnea and similar abnormally slow breathing disorders in obese people. (news-medical.net)
- These high levels of the cation channel in turn may lead to the low respiration rates observed in obese mice with TRPM7. (news-medical.net)
- a Blood plasma solutes and proteins pass through the glomerular filter. (springer.com)
- In addition to being permeable to water, some Aquaporins can be permeable to small solutes, including cations, glycerol and gases. (adejournal.com)
- A dopamine plasma membrane transporter protein complex located on the membrane of dopaminergic neurons. (nih.gov)
- accepted May 29, 1998 Recently, we demonstrated that the 36 kDa catalytic subunit of protein phosphatase 2A (PP2Ac) undergoes methylation at its. (silverchair.com)
- Their nuclear matrix proteins (NMPs) were selectively extracted and subjected to two-dimensional gel electrophoresis analysis. (big.ac.cn)
- XIII" YMR047C 3 13 3 YMR047C "Nuclear pore complex protein that is member of GLFG repeat-containing family of nucleoporins and is,XIII" YMR049C 3 13 4 YMR049C "Ymr049cp,XIII" YMR051C 3 13 5 YMR051C "TyA Gag protein. (davidson.edu)