A ubiquitously-expressed cysteine peptidase that exhibits carboxypeptidase activity. It is highly expressed in a variety of immune cell types and may play a role in inflammatory processes and immune responses.
A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
A cysteine endopeptidase found in NATURAL KILLER CELLS and CYTOTOXIC T-LYMPHOCYTES. It may have a specific function in the mechanism or regulation of cytolytic activity of immune cells.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
An ubiquitously-expressed lysosomal cysteine protease that is involved in protein processing. The enzyme has both endopeptidase and aminopeptidase activities.
An activating NK cell lectin-like receptor subfamily that regulates immune responses to INFECTION and NEOPLASMS. Members of this subfamily generally occur as homodimers.
Antibodies produced by a single clone of cells.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Condensed areas of cellular material that may be bounded by a membrane.
A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.
Substances used to destroy or inhibit the action of rats, mice, or other rodents.
The reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
The use of community resources, individual case work, or group work to promote the adaptive capacities of individuals in relation to their social and economic environments. It includes social service agencies.
The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Individual's rights to obtain and use information collected or generated by others.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A species of nematode that is widely used in biological, biochemical, and genetic studies.
Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.

Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. (1/15)

A novel murine cysteine protease from the family of papain-like cysteine proteinases was identified by dbEST-database search. A 1. 4-kb full-length cDNA encoding a predicted polypeptide of 306 amino acids was characterized. The new protease, tentatively named cathepsin Z, exhibits all features characteristics of a papain-like cysteine protease, including the highly conserved residues of the 'catalytic triad'. Cathepsin Z shares only 26-35% overall homology with previously described mammalian papain-like cysteine peptidases and has an unusually short propeptide, which may indicate that it is a member of a putative new subfamily within the family of papain-like cysteine peptidases. Genomic clones covering the murine and human cathepsin Z genes were isolated. They comprise six exons and five introns spanning a 12-kb region of genomic DNA, respectively. Murine cathepsin Z was mapped to chromosome 2, a region with synteny homology to a region of human chromosome 20 to which human cathepsin Z has been mapped previously. Northern blot analysis revealed ubiquitous expression of murine cathepsin Z. Multiple transcriptional start sites were identified for the murine cathepsin Z gene and together with the absence of a TATA box, a high G+C content, a CpG island and the presence of several Sp1-binding sites in the promoter region, murine cathepsin Z may be classified as a 'housekeeping' gene.  (+info)

Capturing protein interactions in the secretory pathway of living cells. (2/15)

The secretory pathway is composed of membrane compartments specialized in protein folding, modification, transport, and sorting. Numerous transient protein-protein interactions guide the transport-competent proteins through the secretory pathway. Here we have adapted the yellow fluorescent protein (YFP)-based protein fragment complementation assay (PCA) to detect protein-protein interactions in the secretory pathway of living cells. Fragments of YFP were fused to the homooligomeric cargo-receptor lectin endoplasmic reticulum Golgi intermediate compartment (ERGIC)-53, to the ERGIC-53-interacting multi-coagulation factor deficiency protein MCFD2, and to ERGIC-53's cargo glycoprotein cathepsin Z. YFP PCA analysis revealed the oligomerization of ERGIC-53 and its interaction with MCFD2, as well as its lectin-mediated interaction with cathepsin Z. Mutation of the lectin domain of ERGIC-53 selectively decreased YFP complementation with cathepsin Z. Using YFP PCA, we discovered a carbohydrate-mediated interaction between ERGIC-53 and cathepsin C. We conclude that YFP PCA can detect weak and transient protein interactions in the secretory pathway and hence is a powerful approach to study luminal processes involved in protein secretion. The study extends the application of PCA to carbohydrate-mediated protein-protein interactions of low affinity.  (+info)

Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. (3/15)

 (+info)

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. (4/15)

 (+info)

Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts. (5/15)

 (+info)

Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection. (6/15)

 (+info)

Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. (7/15)

 (+info)

Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. (8/15)

 (+info)

Cathepsin Z, also called cathepsin X or cathepsin P, is a protein that in humans is encoded by the CTSZ gene. It is a member of the cysteine cathepsin protease family, which has 11 members. As one of the 11 cathepsins, cathepsin Z contains distinctive features from others. Cathepsin Z has been reported involved in cancer malignancy and inflammation. The CTSZ gene is located at 20q13.32 on chromosome 20, consisting of 6 exons. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined. Cathepsin Z is characterized by an unusual and unique 3-amino acid insertion in the highly conserved region between the glutamine of the putative oxynion hole and the active site cysteine. The pro-region of cathepsin Z shares no significant similarity with other cathepsin family sequences. It contains only 41 amino acid residues without the conserved motif of ERFNIN or GNFD found in other cysteine proteinases. Besides, the proregion sequence ...
specificalPrinciple of the Assay: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Cathepsin Z (CTSZ). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Cathepsin Z (CTSZ). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Cathepsin Z (CTSZ), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Cathepsin Z (CTSZ) in the samples is then determined by comparing the O.D. of the samples to the standard curve. ...
Rabbit monoclonal antibody raised against a human CTSZ peptide using ARM Technology. A synthetic peptide of human CTSZ is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence. (H00001522-K) - Products - Abnova
Positive cells in gastric mucosa of ctsz2/2 (p = 0.009) and wt mice (p = 0.001). Compared to wt animals with no further increase in F4/80 positivity, ctsz2/2
Newly published research explores the role of 14-3-3σ in tumour suppression New research out of McGill Universitys Goodman Cancer Research Centre provides compelling new evidence that a gene known as 14-3-3σ plays a critical role in halting breast cancer initiation and progression. The study, led by the Dept. of Biochemistrys William J. Muller, will be published online today in the journal Cancer Discovery. The discovery of this new target points to novel therapies that eventually could slow or stop breast cancer progression. Muller also says that this gene is likely a major player in a number of other types of cancer. Based on past clinical observations revealing that the expression of gene 14-3-3σ is silenced in a large percentage of breast cancers, researchers had long suspected that it played a role in stopping cancer cells from dividing. The McGill team wanted to confirm whether this was the case. Using a transgenic mouse model that expresses ErbB2, an oncogene associated with aggressive
The effects of autonomic innervation of tumors on tumor growth remain unclear. Here we developed a series of genetic techniques to manipulate autonomic innervation in a tumor- and fiber-type-specific manner in mice with human breast cancer xenografts and in rats with chemically induced breast tumors. Breast cancer growth and progression were accelerated following stimulation of sympathetic nerves in tumors, but were reduced following stimulation of parasympathetic nerves. Tumor-specific sympathetic denervation suppressed tumor growth and downregulated the expression of immune checkpoint molecules (programed death-1 (PD-1), programed death ligand-1 (PD-L1), and FOXP3) to a greater extent than with pharmacological α- or β-adrenergic receptor blockers. Genetically induced simulation of parasympathetic innervation of tumors decreased PD-1 and PD-L1 expression. In humans, a retrospective analysis of breast cancer specimens from 29 patients revealed that increased sympathetic and decreased parasympathetic
We found that the loss of this expression did, in fact, result in a dramatic acceleration of tumour onset, explained Muller who is also affiliated with the Research Institute of the McGill University Health Centre (RI MUHC). The two genes, 14-3-3ó and ErbB2, co-operate, with 14-3-3ó being the brakes. If you lose the brakes, ErbB2 can induce the cells to divide indefinitely. Furthermore, not only is the ability of these cells to divide enhanced but they become extraordinarily metastatic. They can invade distant sites.. Co-authors include Chen Ling, Vi-Minh-Tri Su and Dongmei Zuo. All are from the Goodman Cancer Research Centre and McGills Faculty of Medicine in the Dept. of Biochemistry. All authors were supported by grants from the Canadian Institutes of Health Research (CIHR) and the Terry Fox Foundation.. We are pleased that our funding has led to a better understanding of molecular mechanisms of breast cancer development, which ultimately will lead to improved interventions for breast ...
Fast delivery of CTSZ knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. Includes matched wildtype control.
Citation Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, Sassetti CM. 2016. Tuberculosis susceptibility and vaccine protection are independently controlled by host genotype. mBio 7(5):e01516-16. doi:10.1128/mBio.01516-16. ...
Konsumentverket, Swedens consumer affairs agency, has issued a warning to licensed online gambling operators of their duties in providing balanced and fair conditions to consumers. The agency stated that it had found numerous shortcomings having undertaken a review of terms and conditions across 13 operators picked at random. The operators reviewed by Konsumentverket were AG Communications, Bayton, Blue Star Planet, ComeOn Sweden, Ellmount Gaming, Genesis Global, Interwetten, MOA Gaming Sweden, Pixel Digital, Smarkets, Svenska Spel, Videoslots and Zecure Gaming. Konsumentverket said that it had uncovered deficiencies across operators websites related to withdrawal restrictions, ID and verification requirements, liability disclaimers, inconsistent terms of play and unclear promotions.. In its review, the agency found that 11 firms had applied contract terms on customer registration without disclosing what documentation customers must provide in order to be verified.. Meanwhile, four ...
New AWS database migration capabilities continue to lower the barrier for enterprise adoption as Amazon maintains its push to get IT shops off Oracle.
MDA MB 468 cells expressing shcontrol showed robust migration capabilities as evident by filling the empty JNJ-7706621 ic50 area left following the removal of
Expression of CTSZ (CTSX) in small intestine tissue. Antibody staining with HPA049876, HPA053504 and CAB025114 in immunohistochemistry.
Expression of CTSZ (CTSX) in bone marrow tissue. Antibody staining with HPA049876, HPA053504 and CAB025114 in immunohistochemistry.
Ryan, M P.; Smyth, H; and Hingerty, D, The effects of potassium and magnesium deficiencies on composition and growth rates of ascites tumour cells in mice. Abstr. (1967). Subject Strain Bibliography 1967. 430 ...
We examine whether public disclosure of Deloitte 2007 PCAOB Part II report, which identifies quality control deficiencies related to audits of income tax accoun
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience ...
ADAM17,APAF1,CASP1,CASP12,CASP4,CASP7,CELA1,CFD,CNDP1,CPQ,CTSE,CTSS,CTSZ,DPP7,ENPEP,ERAP1,F2R,FAM188A,FGL2,GGH,GZMA,LGMN,LTA4H,MME,MMP1,MMP13,MMP15,MMP2,MMP8,MMP9,OTUB2,PLAT,PLAU,PLG,PSMB10,PSMB8,PSMB9,ST14, ...
Tumor associated macrophages(TAMs) represent a major part of immune cells in tumor microenvironment(TME) and play crucial roles in promoting tumor progression by secreting cytokines or enzymes that could remodel TME or enhance envision or migration capabilities of tumor cells. Given their indispensable effect on tumor, the mechanisms underlying TAMs tumor-promoting phenotype and function remain unclear. Glucose metabolism in tumor cells has been intensively studied; however, the status of glucose metabolism of TAMs is still unclear. In this study, we aim to identify glucose metabolism status in TAMs, and explore how glucose metabolism regulates phenotype and function of TAMs. In the begining, we isolated TAMs from 4T1 mouse breast tumor, spleen macrophages from normal mouse as a control, and performed RNA sequencing to analyze the expression pattern in glucose metabolism related genes. The results from transcriptomics showed that TAM shown up regulation of glycolysis genes pattern. Then we ...
Vitamins and supplements are vital right now over at any time since our foodstuff consists of much less nutrients, our atmosphere is much more harmful and Virtually all People in america have nutritional deficiencies on account of poor or inadequate taking in habits. Guys and women who routinely choose supplements Reside six-eight a long time for a longer period, and healthier ...
Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS), we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) with variants previously implicated in TB disease susceptibility. The probability that these variants had a predicted regulatory function was estimated using RegulomeDB and Ensembls Variant Effect Predictor. Subsequent genotyping of these 133 predicted regulatory polymorphisms was performed in 400 admixed South African TB cases and 366 healthy controls in a population-based case-control association study to fine-map the causal variant. We detected associations between tuberculosis susceptibility and six intronic polymorphisms located in MARCO, IFNGR2, ASHAS2, ACACA, NISCH and TLR10. Our post- GWAS approach demonstrates the feasibility of combining multiple TB GWAS datasets with linkage information to identify regulatory variants associated with this infectious disease.. ...
Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl carboxypeptidase pathway. The propeptide region of cathepsin X, the shortest among papain-like peptidases, is covalently attached to the active site cysteine in the inactive form of the enzyme. Little is known about the biological function of cathepsin X. Some studies point to a role in early tumorigenesis. A more recent study indicates that cathepsin X expression is restricted to immune cells suggesting a role in phagocytosis and the regulation of the immune response. ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
Introduction. Core Practical Write Up Investigate the effect of plant mineral deficiencies Planning Dependant variable: we are going to be observing the changes in root length, plant body length, number of living leaves and colours of leaves. Independent variable: we will be varying the mineral deficiency in the agar jellies. There will be five ager jelly dishes. There will be one dish containing all nutrients; one dish lacking magnesium; one dish lacking nitrogen; one dish lacking calcium; and one without any of those nutrients. Controlled variables: We are going to be controlling the type of plant growing in the agar jelly. We are using Mexican hat plantlets for our experiment. The time between each measurement is going to be controlled, when one plant is observed all the other plants will also be observed so plants have equal amounts of time to grow. Hypothesis: From what I have learnt in class when a plant lacks nitrogen it should be unable to grow larger because amino acids production will ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Global Markets Directs, Cathepsin K (Cathepsin O or Cathepsin O2 or Cathepsin X or CTSK or EC 3.4.22.38) - Pipeline Review, H1 2019, provides
Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (TB) in up to 514 cases and 913 controls from Karonga district, northern Malawi. Homozygosity for the complement receptor 1 (CR1) Q1022H polymorphism was associated with susceptibility to TB in this population (odds ratio [OR] = 3.12, 95% Confidence interval [CI] = 1.13-8.60, P = 0.028). This association was not observed among human immunodeficiency virus (HIV)-positive TB cases, suggesting either chance association or that HIV status may influence genetic associations with TB susceptibility. Heterozygosity for a newly studied CAAA insertion/deletion polymorphism in the 3-untranslated region of solute carrier family 11, member 1 (SLC11A1, formerly NRAMP1) was associated with protection against TB in both HIV-positive (OR = 0.70, 95% CI = 0.49-0.99, P = 0.046) and HIV-negative (OR = 0.65, 95% CI = 0.46-0.92, P = 0.014) TB cases, suggesting that the SLC11A1 protein may have a role in innate TB immune
Какое ваше мнение? Обязательно ли снимать кафе или же устраивать этот бесбашковитый фуршет и манить араву родственников а-ля цыганский табор - всех своих берем с собой???,До 23 лет мучалась с этой девственностью, некоторое количество попыток было с ней попрощаться и всё нет , нет, больно,больно!!! и что в итоге?-ничего болезненного особо не было, только при входе.больше страху нагоняла и форумов обчиталась до седины) единстенно что приятно в этой многолетней ситуации так это то-, что с возлюбленным человеком... вот не редки и такие случаиое почитаемые ...
TY - JOUR. T1 - The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver. AU - Arthur, J R. AU - Morrice, P C. AU - Nicol, F. AU - Beddows, S E. AU - Boyd, R. AU - Hayes, J D. AU - Beckett, G J. PY - 1987/12/1. Y1 - 1987/12/1. N2 - Selenium (Se) deficiency in rats produced significant increases in the activity of hepatic glutathione S-transferase (GST) with 1-chloro-2,4-dinitrobenzene as substrate and in various GST isoenzymes when determined by radioimmunoassay. These changes is GST activity and concentration were associated with Se deficiency that was severe enough to provoke decreases of over 98% in hepatic Se-containing glutathione peroxidase activity (Se-GSHpx). However, decreases in hepatic Se-GSHpx of 60% induced by copper (Cu) deficiency had no effect on GST activity or concentration. Increased GST activity in Se deficiency has previously been postulated to be a compensatory response to loss of Se-GSHpx, since some GSTs have a ...
Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and dissection of this may enlighten on the
Hess, Silvia; Alve, Elisabeth; Trannum, Hilde Cecilie & Norling, Karl (2013). Benthic foraminiferal responses to water-based drill cuttings and natural sediment burial: Results from a mesocosm experiment. Marine Micropaleontology. ISSN 0377-8398. 101, s 1- 9 . doi: 10.1016/j.marmicro.2013.03.004 Show summary Effects of burial by water-based drill cuttings and natural test sediment on living (stained) benthic foraminifera were investigated in a mesocosm experiment. After 193 days, the foraminiferal response in sediment covered with drill cuttings was compared to the response in sediment covered with defaunated natural test sediment. Increasing thickness of added material, independent of type of material, significantly reduced the benthic foraminiferal abundance and species richness. While most species managed to migrate through added sediments of up to 12 mm thickness, results indicate that a burial depth of 24 mm severely limits the migration capability of the foraminifera. Textularia earlandi ...
Nonlinear delay-differential equations represent infinite-dimensional systems for which characterising the behaviour of solutions can be technically challenging. Their appearance in many applied fields, such as population biology, is in great part due to their ability to model dynamics with non-instantaneous effects. These phenomena often exhibit behaviour which does not occur in the associated non-delayed counterpart. In particular, it is known that delays can trigger the occurrence of oscillatory behaviour and can, in several cases, bring evidence for mechanisms underlying oscillations in biological systems. Oscillatory dynamics play an important role in the accurate regulation of hormones. Such rhythms in the ultradian regime have been observed in multiple physiological areas such as the HPA-axis, phases of sleep, and the glucose regulatory system.. In this contribution, the effect of diabetic deficiencies on the production of an oscillatory ultradian regime is studied using a deterministic ...
When you organize a charity, even medical science may need a hand. The gift of medicine and helping out people who may have some deficiencies on their health is pretty much a growing concern and considering that many people today are suffering in terms of seeking medication and assistance for various health issues, good causes such as charities are a great way to help them out. One of these medical problems deals with hearing. The number of people who suffer from deafness is apparent and while there are medical solutions to it, they do not come cheap. Some have to console themselves with the fact that money talks and unless some good soul or program is raised, the inevitable task of enjoying the sense of hearing will only remain a goal for them. In a move not to really help cure deafness immediately, worthy causes such as the ones being undertaken by the charity Deafness Research UK can do their small part by distributing pamphlets and guiding people suffering from deafness. In the pamphlets, ...
California halibut may be right- or left-eyed. Accurate diagnosis and appropriate plans of management can be achieved with careful history taking and clinical examination. A Decent Proposal. Horners syndrome. You also may lose the crease (fold of skin) that normally lies between your upper eyelid and eyebrow. Theres not much you can do in such scenarios, but you can make alterations on your side to mitigate deficiencies on the other end. So, before you do anything else, make eye contact with the person you plan to wink at. Your baby may be born with a ptosis, or it may develop later. Cover one of your childs eyes and move the object again: left, right, up and down. The slower form is less so, with the affected eye slowly becoming visibly larger than its healthy partner. The rest of the eye can also swell, and rapid. When one of the eyes turns inward this is known as esotropia (crossed eyes). His one eye doesnt slow him down. Cover one eye and then the other and compare the sight in each one. ...
TY - JOUR. T1 - Human Cystatin A Is Inactivated by Engineered Truncation. The NH2-Terminal Region of the Cysteine Proteinase Inhibitor Is Essential for Expression of Its Inhibitory Activity. AU - Shibuya, Kazunori. AU - Kaji, Hiroyuki. AU - Itoh, Takehito. AU - Ohyama, Yukihito. AU - Tsujikami, Akiyoshi. AU - Tate, Shin ichi. AU - Takeda, Atsushi. AU - Kumagai, Izumi. AU - Hirao, Ichiro. AU - Miura, Kin ichiro. AU - Inagaki, Fuyuhiko. AU - Samejima, Tatsuya. PY - 1995/9. Y1 - 1995/9. N2 - A series of NFL-terminal truncated forms of human cysteine proteinase inhibitor, cystatin A, was prepared by genetic engineering using Escherichia coli harboring mutated genes. Each variant of cystatin A was efficiently expressed as a fused protein with porcine adenylate kinase and released by CNBr degradation after exchange of the sole inner Met to Leu. The mutant cystatin A lacking an aminoterminal Met residue (called standard variant starting from Ile2, CystA2-98(M65L)) showed the same inhibitory activity as ...
CHORDC1 - CHORDC1 (untagged)-Human cysteine and histidine-rich domain (CHORD) containing 1 (CHORDC1), transcript variant 2 available for purchase from OriGene - Your Gene Company.
Cathepsin: Cathepsins ( Ancient Greek kata- "down" and hepsein "boil"; abbreviated CTS ) are proteases ( enzymes that degrades ... Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are ... There are, however, exceptions such as cathepsin K, which works extracellularly after secretion by osteoclasts in bone ...
"Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like ... Wex T, Levy B, Wex H, Brömme D (1999). "Human cathepsins F and W: A new subgroup of cathepsins". Biochem. Biophys. Res. Commun ... 2003). "Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal ... Cathepsin W is a protein that in humans is encoded by the CTSW gene.[5][6][7] ...
"Entrez Gene: CTSD cathepsin D".. *^ Barrett AJ (April 1970). "Cathepsin D. Purification of isoenzymes from human and chicken ... Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes.[7] The main function of cathepsin D is ... The optimum pH for cathepsin D in vitro is 4.5-5.0.[13] Cathepsin-D is an aspartic protease that depends critically on ... Cathepsin D is a protein that in humans is encoded by the CTSD gene.[5][6] This gene encodes a lysosomal aspartyl protease ...
Cathepsin A (serine protease) Cathepsin B (cysteine protease) Cathepsin C (cysteine protease) Cathepsin D (aspartyl protease) ... Cathepsin H (cysteine protease) Cathepsin K (cysteine protease) Cathepsin L1 (cysteine protease) Cathepsin L2 (or V) (cysteine ... Cathepsin S (cysteine protease) Cathepsin W (cysteine proteinase) Cathepsin Z (or X) (cysteine protease) Cathepsins have been ... Cathepsin K has also been shown to play a role in arthritis. Mouse cathepsin L is homologous to human cathepsin V. Mouse ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Cathepsin T (EC 3.4.22.24) is an enzyme. This enzyme catalyses the following chemical reaction Interconversion of the three ... Cathepsin Gohda E, Pitot HC (May 1981). "Purification and characterization of a new thiol proteinase from rat kidney". ... Cathepsin+T at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... Pitot HC, Gohda E (1987). "Cathepsin T". Methods in Enzymology. 142: 279-89. doi:10.1016/s0076-6879(87)42038-7. PMID 2885716. ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
cathepsin K. Names. cathepsin O. cathepsin O1. cathepsin O2. cathepsin X. NP_000387.1. *EC 3.4.22.38 ... Metabolic mapping showed that cathepsin B, but not cathepsin K is active in GSC niches. Title: Cysteine cathepsins B, X and K ... cathepsin K in the development of chronic subdural hematoma Title: Role of cathepsin K in the development of chronic subdural ... Cathepsin K degradation of sclerostin is affected by hypoxia. Title: The regulation of sclerostin by cathepsin K in periodontal ...
Cathepsin B. A. 266. Homo sapiens. Mutation(s): 3 Gene Names: CTSB, CPSB. EC: 3.4.22.1. ... Cathepsin B is a papain-like cysteine protease showing both endo- and exopeptidase activity, the latter due to a unique ... Cathepsin B is a papain-like cysteine protease showing both endo- and exopeptidase activity, the latter due to a unique ... The chagasin-cathepsin B complex provides a structural framework for modeling and design of inhibitors for cruzipain, the ...
Incubation with the cathepsin L specific inhibitor, Z-FY-DMK, blocked cathepsin L signals, confirming the cathepsin L bands in ... Z-FY-DMK cathepsin L inhibitor does not inhibit all cathepsin activity of murine endometriotic lesions. Incubation with Z-FY- ... DMK, a selective inhibitor of cathepsin L, inhibited many of the cathepsin active bands but did not block all active cathepsin ... E-64 blocks all cathepsin proteolytic activity in murine endometriotic lesions. Incubation with the broad cathepsin inhibitor, ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Cathepsins are proteases, which are enzymes that are responsible for degrading proteins. There are around 12 different types of ... Cathepsin inhibitors can stop cathepsin function, which can stop tumors from forming through blocking angiogenesis. Cathepsin ... but some cathepsins function above the optimal pH 5 level, namely cathepsin S, which is active at pH 6.5. Cathepsin D is ... Cathepsin Z (or X). All cathepsins are made up of a signal peptide, a propeptide, and a mature functional enzyme that is ...
V. Zavanik-Bergant, A. Sekirnik, R. Golouh, V. Turk, and J. Kos, "Immunochemical localisation of cathepsin S, cathepsin L and ... Both stimulants caused a significant cathepsin S upregulation. A significantly elevated cathepsin S expression in gingival ... Role of Cathepsin S in Periodontal Inflammation and Infection. S. Memmert,1,2 A. Damanaki,1 A. V. B. Nogueira,3 S. Eick,4 M. ... "Antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L," Biochemistry, ...
Cathepsin K degrades both collagen and elastin, and is one of the most powerful proteases. Cathepsin S degrades elastin, and ... "We saw that the cathepsin K was going away much faster when there was cathepsin S present than when it was by itself," said ... "We kept increasing the amount of cathepsin S until the collagen was not affected at all because all of the cathepsin K was ... Barrys modeling suggested that effects observed could occur if cathepsin S were degrading cathepsin K instead of attacking the ...
The cathepsin S protease is implicated in generation of chronic pain by releasing a cytokine. ... The cathepsin S protease is implicated in generation of chronic pain by releasing a cytokine. ...
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Graham Simmons, Dhaval N. Gosalia, ... Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Graham Simmons, Dhaval N. Gosalia, ... Cathepsin-L-specific inhibitor blocks infection. (A) MDL28170 inhibits CTSL activity with an IC50 of 2.5 nM. A 1,000-compound ... Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry Message Subject (Your Name) has sent you ...
A direct immunohistochemical method of high specificity is presented for the demonstration of sites of cathepsin B1. Antisera ... Snellman, O.: Cathepsin B, the lysosomal thiol proteinase of calf liver. Biochem. J. 114, 673-678 (1969)Google Scholar ... Otto, K.: Cathepsins B1 and B2. In: Tissue proteinases, ed. by A. J. Barrett and J. T. Dingle, p. 1-28. North-Holland ... V. Cathepsin B as a potential effector of LNA hydrolysis. Histochemie 12, 240-243 (1968)Google Scholar ...
Cathepsin S is a cysteine protease highly expressed in many type of cancers including colorectal, prostate, breast, and ... This mini-review provides an overview of therapeutic antibody targeting Cathepsin S strategies in the last half decade, ... In recent years, antibody research specifically targeting Cathepsin S to block/inhibit tumorigenic effects were generated some ... focusing on the rationale of cell-surface Cathepsin S targeted and their potential clinical application. ...
Rabbit polyclonal Cathepsin E antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 3 publication(s ... Anti-Cathepsin E antibody (ab36996) at 1/1000 dilution + Murine reticulocyte lysate at 10 µg. Predicted band size: 42 kDa. ... High Expression of Cathepsin E in Tissues but Not Blood of Patients with Barretts Esophagus and Adenocarcinoma.. Ann Surg ... Cathepsin E is expressed abundantly in the stomach, Clara cells and alveolar macrophages of the lung, brain microglia, spleen, ...
Rabbit polyclonal Cathepsin D antibody validated for WB, ELISA, IHC, ICC/IF and tested in Human. Referenced in 1 publication ... This antibody reacts with human liver cathepsin D, and does not react with cathepsins B, H and L. ... IHC image of Cathepsin D staining in Human Lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ ... Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin D antibody (ab19555) ...
... administration of rat recombinant cathepsin B and rat recombinant cathepsin L at the same or higher doses than rrCatS had no ... Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Anna K. Clark, Ping K. Yip, John Grist, Clive ... cathepsin S;. rrCatS,. rat recombinant CatS;. LHVS,. morpholinurea-leucine-homophenylalanine-vinyl phenyl sulfone;. PNL,. ... Here, we report that in peripheral nerve-injured rats, the lysosomal cysteine protease cathepsin S (CatS) is critical for the ...
Protease activity Apolipoprotein A-I Aortic valve stenosis Cathepsin S C. Gebhard and F. Maafi contributed equally to this work ... Hooshdaran B, Kolpakov MA, Guo X, Miller SA, Wang T, Tilley DG, Rafiq K, Sabri A (2017) Dual inhibition of cathepsin G and ... Lindstedt L, Lee M, Oorni K, Bromme D, Kovanen PT (2003) Cathepsins F and S block HDL3-induced cholesterol efflux from ... Targeting circulating cathepsin S may lead to new therapies for human aortic valve disease. ...
Cathepsin B. Cathepsin B, EC 3.4.22.1 (APP secretase, APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B ... Cathepsin BImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/ ... tr,E9PL32,E9PL32_HUMAN Cathepsin B (Fragment) OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=2 ...
Cathepsin GAdd BLAST. ›26. Proteomic databases. PaxDb, a database of protein abundance averages across all three domains of ... sp,P17977,CATG_RAT Cathepsin G (Fragment) OS=Rattus norvegicus GN=Ctsg PE=1 SV=1 IIGGREARPNSHPYMAFLLIQSPEGL ...
Cathepsin G is the serine protease released by neutrophils upon their activation. Cathepsin G is currently being explored as a ... Cathepsins - A class of globular lysosomal proteases. Cathepsins play a vital role in mammalian cellular turnover. There are ... Cathepsin L, a lysosomal endopeptidase, is a member of the papain-like family of cysteine proteinases. It is involved in the ... Cathepsin E is a non-lysosomal aspartic proteinase of the pepsin superfamily. It plays an important role in protein degradation ...
MAGIC RED® CATHEPSIN B KIT. A fluorogenic test kit for Cathepsin B. (Patent# 6,235,493-May 22, 2001). Ref.: 1. Van Noorden, C.J ... MAGIC RED® CATHEPSIN K KIT. A fluorogenic test kit for Cathepsin K. (Patent# 6,235,493-May 22, 2001). Ref.: 1. Van Noorden, C.J ... MAGIC RED® CATHEPSIN L KIT. A fluorogenic test kit for Cathepsin L. (Patent# 6,235,493-May 22, 2001). Ref.: 1. Van Noorden, C.J ...
Cathepsin K Polyclonal Antibody from Invitrogen for Western Blot, Immunohistochemistry (Paraffin) and Flow Cytometry ... Protein Aliases: Cathepsin K; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin X; CTSK; CTSO; CTSO2 ... Cite Cathepsin K Polyclonal Antibody. The following antibody was used in this experiment: Cathepsin K Polyclonal Antibody from ...
Although a lysosomal, cathepsin B-dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this ...
C.-S. Hsieh, P. DeRoos, K. Honey, C. Beers, and A. Y. Rudensky, "A role for cathepsin L and cathepsin S in peptide generation ... J. Ärnlv, "Cathepsin S as a biomarker: where are we now and what are the future challenges?" Biomarkers in Medicine, vol. 6, no ... Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Jianguo Xu,1 Handong Wang,1 Ke ... D. M. Small, R. E. Burden, and C. J. Scott, "The emerging relevance of the cysteine protease cathepsin S in disease," Clinical ...
Cathepsin D purified from a mutant strain has a lower activity per unit mass of pure enzyme. These data suggest that cad-1 is a ... Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.. L A Jacobson, L Jen-Jacobson, J M ... Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.. L A Jacobson, L Jen-Jacobson, J M ... Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.. L A Jacobson, L Jen-Jacobson, J M ...

No FAQ available that match "cathepsin z"

No images available that match "cathepsin z"