OrganismsDiseasesChemicals and Drugs
Cathepsin FCathepsinsCathepsin WCathepsin BCathepsin LOpisthorchisCathepsin DCathepsin KOpisthorchiasisCathepsin GCathepsin HCathepsin ECysteine EndopeptidasesCathepsin C
Cathepsin F
A lysosomal papain-related cysteine proteinase that is expressed in a broad variety of cell types.
Cathepsins
A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.
Cathepsin W
A cysteine endopeptidase found in NATURAL KILLER CELLS and CYTOTOXIC T-LYMPHOCYTES. It may have a specific function in the mechanism or regulation of cytolytic activity of immune cells.
Cathepsin B
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
Cathepsin L
A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.
Opisthorchis
A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS.
Cathepsin D
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
Cathepsin K
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Opisthorchiasis
Infection with flukes of the genus Opisthorchis.
Cathepsin G
A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.
Cathepsin H
An ubiquitously-expressed lysosomal cysteine protease that is involved in protein processing. The enzyme has both endopeptidase and aminopeptidase activities.
Cathepsin E
An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the cells of the immune system where it may play a role in processing of CELL SURFACE ANTIGENS.
Cysteine Endopeptidases
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
Cathepsin C
A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.

Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. (1/18)

A cDNA encoding a new cysteine proteinase belonging to the papain family and called cathepsin F has been cloned from a human prostate cDNA library. This cDNA encodes a polypeptide of 484 amino acids, with the same domain organization as other cysteine proteinases, including a hydrophobic signal sequence, a prodomain, and a catalytic region. However, this propeptide domain is unusually long and distinguishes cathepsin F from other proteinases of the papain family. Cathepsin F also shows all structural motifs characteristic of these proteinases, including the essential cysteine residue of the active site. Consistent with these structural features, cathepsin F produced in Escherichia coli as a fusion protein with glutathione S-transferase degrades the synthetic peptide benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin, a substrate commonly used for functional characterization of cysteine proteinases. Furthermore, this proteolytic activity is blocked by trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane, an inhibitor of cysteine proteinases. The gene encoding cathepsin F maps to chromosome 11q13, close to that encoding cathepsin W. Cathepsin F is widely expressed in human tissues, suggesting a role in normal protein catabolism. Northern blot analysis also revealed a significant level of expression in some cancer cell lines opening the possibility that this enzyme could be involved in degradative processes occurring during tumor progression.  (+info)

Role of N-glycosylation in cathepsin E. A comparative study of cathepsin E with distinct N-linked oligosaccharides and its nonglycosylated mutant. (2/18)

Cathepsin E (CE), a nonlysosomal, intracellular aspartic proteinase, exists in several molecular forms that are N-glycosylated with high-mannose and/or complex-type oligosaccharides. To investigate the role of N-glycosylation on the catalytic properties and molecular stability of CE, both natural and recombinant enzymes with distinct oligosaccharides were purified from different sources. An N-glycosylation minus mutant, that was constructed by site-directed mutagenesis (by changing asparagine residues to glutamine and aspartic acid residues at positions 73 and 305 in potential N-glycosylation sites of rat CE) and expressed in normal rat kidney cells, was also purified to homogeneity from the cell extracts. The kinetic parameters of the nonglycosylated mutant were found to be essentially equivalent to those of natural enzymes N-glycosylated with either high-mannose or complex-type oligosaccharides. In contrast, the nonglycosylated mutant showed lower pH and thermal stabilities than the glycosylated enzymes. The nonglycosylated mutant exhibited particular sensitivity to conversion to a monomeric form by 2-mercaptoethanol, as compared with those of the glycosylated enzymes. Further, the high-mannose-type enzymes were more sensitive to this agent than the complex-type proteins. A striking difference was found between the high-mannose and complex-type enzymes in terms of activation by ATP at a weakly acidic pH. At pH 5.5, the complex-type enzymes were stabilized by ATP to be restored to the virtual activity, whereas the high-mannose-type enzymes as well as the nonglycosylated mutant were not affected by ATP. These results suggest that N-glycosylation in CE is important for the maintenance of its proper folding upon changes in temperature, pH and redox state, and that the complex-type oligosaccharides contribute to the completion of the tertiary structure to maintain its active conformation in the weakly acidic pH environments.  (+info)

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. (3/18)

The major histocompatibility complex (MHC) class II-associated invariant chain (Ii) regulates intracellular trafficking and peptide loading of MHC class II molecules. Such loading occurs after endosomal degradation of the invariant chain to a approximately 3-kD peptide termed CLIP (class II-associated invariant chain peptide). Cathepsins L and S have both been implicated in degradation of Ii to CLIP in thymus and peripheral lymphoid organs, respectively. However, macrophages from mice deficient in both cathepsins S and L can process Ii and load peptides onto MHC class II dimers normally. Both processes are blocked by a cysteine protease inhibitor, indicating the involvement of an additional Ii-processing enzyme(s). Comparison of cysteine proteases expressed by macrophages with those found in splenocytes and dendritic cells revealed two enzymes expressed exclusively in macrophages, cathepsins Z and F. Recombinant cathepsin Z did not generate CLIP from Ii-MHC class II complexes, whereas cathepsin F was as efficient as cathepsin S in CLIP generation. Inhibition of cathepsin F activity and MHC class II peptide loading by macrophages exhibited similar specificity and activity profiles. These experiments show that cathepsin F, in a subset of antigen presenting cells (APCs), can efficiently degrade Ii. Different APCs can thus use distinct proteases to mediate MHC class II maturation and peptide loading.  (+info)

Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. (4/18)

Alterations in cathepsin L expression and trafficking have been associated with the progression and metastasis of several tumor entities. In the present study, we examined the effects of various cathepsin L antisense (as) phosphorothioate oligonucleotides on both the expression of cathepsin L and the invasive potential of the human osteosarcoma cell line MNNG/HOS. Seven oligonucleotides of 20-bp length each and one random control oligonucleotide were chosen to block cathepsin L expression. Northern blot analysis demonstrated a significant reduction in cathepsin L mRNA expression by the six antisense oligonucleotides at a concentration of 10 microM. Cathepsin L protein expression was reduced significantly (50-85%) by the antisense oligonucleotides, as compared with the controls. Adhesion to matrices of collagen I and matrigel was not affected. In in vitro motility and invasion assays performed in uncoated and precoated transwell chambers, the ability of cells to migrate through the filters was inhibited by 35-75% using antisense oligonucleotides. The random control did not show any inhibitory effect. These data demonstrate that in MNNG/HOS cells cathepsin L influences cellular malignancy by promoting migration and basement membrane degradation.  (+info)

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro. (5/18)

During atherogenesis, low density lipoprotein (LDL) particles in the arterial intima become modified and fuse to form extracellular lipid droplets. Proteolytic modification of apolipoprotein (apo) B-100 may be one mechanism of droplet formation from LDL. Here we studied whether the newly described acid protease cathepsin F can generate LDL-derived lipid droplets in vitro. Treatment of LDL particles with human recombinant cathepsin F led to extensive degradation of apoB-100, which, as determined by rate zonal flotation, electron microscopy, and NMR spectroscopy, triggered both aggregation and fusion of the LDL particles. Two other acid cysteine proteases, cathepsins S and K, which have been shown to be present in the arterial intima, were also capable of degrading apoB-100, albeit less efficiently. Cathepsin F treatment resulted also in enhanced retention of LDL to human arterial proteoglycans in vitro. Cultured monocyte-derived macrophages were found to secrete active cathepsin F. In addition, similarly with cathepsins S and K, cathepsin F was found to be localized mainly within the macrophage-rich areas of the human coronary atherosclerotic plaques. These results suggest that proteolytic modification of LDL by cathepsin F may be one mechanism leading to the extracellular accumulation of LDL-derived lipid droplets within the proteoglycan-rich extracellular matrix of the arterial intima during atherogenesis.  (+info)

Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. (6/18)

BACKGROUND: Cervical carcinoma (CC) is one of the most common cancers among women worldwide and the first cause of death among the Mexican female population. CC progression shows a continuum of neoplastic transitions until invasion. Matrix metalloproteinases (MMPs) and cathepsins play a central role on the enhancement of tumor-induced angiogenesis, cell migration, proliferation, apoptosis and connective tissue degradation. MMPs -2 and -9 expression has been widely studied in cervical cancer. Nevertheless, no other metalloproteinases or cathepsins have been yet related with the progression and/or invasion of this type of cancer. METHODS: Three HPV18 CC cell lines, two HPV16 CC cell lines and three HPV16 tumor CC tissues were compared with three morphologically normal, HPV negative, cervical specimens by cDNA arrays. Overexpression of selected genes was confirmed by end point semiquantitative reverse transcription-PCR with densitometry. In situ hybridization and protein expression of selected genes was further studied by means of two tissue microarrays, one consisting of 10 HSIL and 15 CC and the other one of 15 normal cervical and 10 LSIL tissues. RESULTS: TIMP1, Integrins alpha 1 and 4, cadherin 2 and 11, Cathepsins F, B L2, MMP 9, 10 11 and 12 were upregulated and Cathepsin S, L, H and C, Cadherins 3 and 4, TIMP3, MMP 13, Elastase 2 and Integrin beta 8 were found to be downregulated by cDNA arrays. Endpoint RT-PCR with densitometry gave consistent results with the cDNA array findings for all three genes selected for study (CTSF, MMP11 and MMP12). In situ hybridization of all three genes confirmed overexpression in all the HSIL and CC. Two of the selected proteins were detected in LSIL, HSIL and CC by immunohistochemistry. CONCLUSION: Novel undetected CC promoting genes have been identified. Increased transcription of these genes may result in overexpression of proteins, such as CTSF, MMP11 and MMP12 which could contribute to the pathogenesis of CC.  (+info)

Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. (7/18)

Cathepsin F (cat F) is a widely expressed lysosomal cysteine protease whose in vivo role is unknown. To address this issue, mice deficient in cat F were generated via homologous recombination. Although cat F-/- mice appeared healthy and reproduced normally, they developed progressive hind leg weakness and decline in motor coordination at 12 to 16 months of age, followed by significant weight loss and death within 6 months. cat F was found to be expressed throughout the central nervous system (CNS). cat F-/- neurons accumulated eosinophilic granules that had features typical of lysosomal lipofuscin by electron microscopy. Large amounts of autofluorescent lipofuscin, characteristic of the neurodegenerative disease neuronal ceroid lipofuscinosis (NCL), accumulated throughout the CNS but not in visceral organs, beginning as early as 6 weeks of age. Pronounced gliosis, an indicator of neuronal stress and neurodegeneration, was also apparent in older cat F-/- mice. cat F is the only cysteine cathepsin whose inactivation alone causes a lysosomal storage defect and progressive neurological features in mice. The late onset suggests that this gene may be a candidate for adult-onset NCL.  (+info)

Cloning and expression of the cathepsin F-like cysteine protease gene in Escherichia coli and its characterization. (8/18)

In this study, we have cloned a novel cDNA encoding for a papain-family cysteine protease from the Uni-ZAP XR cDNA library of the polychaete, Periserrula leucophryna. This gene was expressed in Escherichia coli using the T7 promoter system, and the protease was characterized after partial purification. First, the partial DNA fragment (498 bp) was amplified from the total RNA via RT-PCR using degenerated primers derived from the conserved region of cysteine protease. The full-length cDNA of cysteine protease (PLCP) was prepared via the screening of the Uni-ZAP XR cDNA library using the 32P-labeled partial DNA fragment. As a result, the PLCP gene was determined to consist of a 2591 bp nucleotide sequence (CDS: 173-1024 bp) which encodes for a 283-amino acid polypeptide, which is itself composed of an 59-residue signal sequence, a 6-residue propeptide, a 218-residue mature protein, and a long 3'-noncoding region encompassing 1564 bp. The predicted molecular weights of the preproprotein and the mature protein were calculated as 31.8 kDa and 25 kDa, respectively. The results of sequence analysis and alignment revealed a significant degree of sequence similarity with other eukaryotic cysteine proteases, including the conserved catalytic triad of the Cys90, His226, and Asn250 residues which characterize the C1 family of papain-like cysteine protease. The nucleotide and amino acid sequences of the novel gene were deposited into the GenBank database under the accession numbers, AY390282 and AAR27011, respectively. The results of Northern blot analysis revealed the 2.5 kb size of the transcript and ubiquitous expression throughout the entirety of the body, head, gut, and skin, which suggested that the PLCP may be grouped within the cathepsin F-like proteases. The region encoding for the mature form of the protease was then subcloned into the pT7-7 expression vector following PCR amplification using the designed primers, including the initiation and termination codons. The recombinant cysteine proteases were generated in a range of 6.3% to 12.5% of the total cell proteins in the E. coli BL21(DE3) strain for 8 transformants. The results of SDS-PAGE and Western blot analysis indicated that a cysteine protease of approximately 25 kDa (mature form) was generated. The optimal pH and temperature of the enzyme were determined to be approximately 9.5 and 35 degrees, respectively, thereby indicating that the cysteine protease is a member of the alkaline protease group. The evaluation of substrate specificity indicated that the purified protease was more active towards Arg-X or Lys-X and did not efficiently cleave the substrates with non-polar amino acids at the P1 site. The PLCP evidenced fibrinolytic activity on the plasminogen-free fibrin plate test.  (+info)

Cathepsin F - WikipediaCathepsin F - Wikipedia
Cathepsin F is a protein that in humans is encoded by the CTSF gene. Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. In general, cathepsins contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251-amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids that contains a 19-residue signal ...
https://en.wikipedia.org/wiki/Cathepsin_F
A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriersA truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers
A recessive, adult-onset neuronal ceroid-lipofuscinosis (NCL) occurs in Tibetan terriers. A genome-wide association study restricted this NCL locus to a 1.3 Mb region of canine chromosome 2 which contains canine ATP13A2. NCL-affected dogs were homozygous for a single-base deletion in ATP13A2, predicted to produce a frameshift and premature termination codon. Homozygous truncating mutations in human ATP13A2 have been shown by others to cause Kufor-Rakeb syndrome (KRS), a rare neurodegenerative disease. These findings suggest that KRS is also an NCL, although analysis of KRS brain tissue will be needed to confirm this prediction. Generalized brain atrophy, behavioral changes, and cognitive decline occur in both people and dogs with ATP13A2 mutations: however, other clinical features differ between the species. For example, Tibetan terriers with NCL develop cerebellar ataxia not reported in KRS patients and KRS patients exhibit parkinsonism and pyramidal dysfunction not observed in affected Tibetan ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:417198
CTSF Gene - GeneCards | CATF Protein | CATF AntibodyCTSF Gene - GeneCards | CATF Protein | CATF Antibody
Complete information for CTSF gene (Protein Coding), Cathepsin F, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=CTSF
Sreeganga S Chandra, PhD > Biological & Biomedical Sciences | Yale...Sreeganga S Chandra, PhD > Biological & Biomedical Sciences | Yale...
My lab explores two related themes, those of synapse loss and neurodegeneration. Synapse loss is an early, defining event in neurodegenerative diseases, such as Parkinsons disease. In these prolonged diseases, decreases in synapse density are the best correlates of disease progression.Yet, little is known about the pathways that maintain synapses and their roles in aging and neurodegeneration. We are characterizing a novel presynaptic mechanism for the prevention of synapse loss and neurodegeneration involving the co-chaperone Cysteine String Protein alpha. This gene is also mutated in adult-onset neuronal ceroid lipofuscinosis, a neurodegenerative disorder with lysosomal pathology. We are also screening for new synapse maintenance genes using a dissociated neuronal culture system ...
http://medicine.yale.edu/bbs/people/sreeganga_chandra-2.profile
Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas - ePrints ...Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas - ePrints ...
The source of new beta-cells in adult human pancreas remains incompletely elucidated with recent studies in rodents providing evidence for neogenesis from progenitor cells in addition to self-replication. The aim of this study was to investigate expression of pluripotency-associated stem cell markers in proliferative cultures derived from adult human pancreas.Human pancreatic tissue was obtained from deceased donors following ethical approval and relative consent. Islet-enriched fraction was separated from the retrieved organ by digestion and density gradient centrifugation. Dissociated cells were seeded in adherent culture forming proliferative islet survivor cells(ISCs). These were characterized at fifth passage by RT-PCR, immunofluorescence staining, FACS, Western blot and transfection studies with an OCT4 promoter-driven reporter.Nuclear expression of the pluripotency-associated stem cell marker complex OCT4 / SOX2 / NANOG was confirmed in ISCs. The phenotype constituted approximately 8% ...
http://eprint.ncl.ac.uk/pub_details2.aspx?pub_id=177128
IJMS | Free Full-Text | Progenitor Cells from Cartilage: Grade Specific Differences in Stem Cell Marker ExpressionIJMS | Free Full-Text | Progenitor Cells from Cartilage: Grade Specific Differences in Stem Cell Marker Expression
Recent research has confirmed the presence of Mesenchymal stem cell (MSC)-like progenitors (MPC) in both normal and osteoarthritic cartilage. However, there is only limited information concerning how MPC markers are expressed with osteoarthritis (OA) progression. The purpose of this study was to compare the prevalence of various MPC markers in different OA grades. Human osteoarthritic tibial plateaus were obtained from ten patients undergoing total knee replacement. Each sample had been classified into a mild or severe group according to OARSI scoring. Tissue was taken from each specimen and mRNA expression levels of CD105, CD166, Notch 1, Sox9, Acan and Col II A1 were measured at day 0 and day 14 (2 weeks in vitro). Furthermore, MSC markers: Nucleostemin, CD90, CD73, CD166, CD105 and Notch 1 were studied by immunofluorescence. mRNA levels of MSC markers did not differ between mild and severe OA at day 0. At day 14, protein analysis showed that proliferated cells from both sources expressed all 6 MSC
http://www.mdpi.com/1422-0067/18/8/1759
The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human...The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human...
The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F
http://nparc.nrc-cnrc.gc.ca/eng/view/object/?id=ddd2a7cd-446b-44b0-bbd6-4a52a1c7757d
Genetic Cause of Kufs Disease Identified by New TechnologyGenetic Cause of Kufs Disease Identified by New Technology
Researchers have made use of an an innovative and new technology to identify the gene responsible for Kufs disease, a rare and fatal hereditary brain disorder.
http://www.medindia.net/news/Genetic-Cause-of-Kufs-Disease-Identified-by-New-Technology-84637-1.htm
INABIS 98 - A Behavioral Validation of the Spontaneously Hypertensive Rat (SHR) as an Animal Model of Attention-Deficit...
International scientific meeting on the Web, with Keynote Addresses, Invited Symposia, Poster Sessions, and an Exhibitors Foyer. Sessions in basic and clinical sciences, education, and public health. Hosted by McMaster University, Hamilton, Ontario, Canada, Dec 7-16th, 1998. symposium Presentation
http://www.mcmaster.ca/inabis98/sadile/sagvolden0567/six.html
Researchers identify gene that causes rare dementing illness - Healthcanal.com : Healthcanal.comResearchers identify gene that causes rare dementing illness - Healthcanal.com : Healthcanal.com
They sequenced DNA from the two related Kufs disease patients and from a first-degree relative who did not have the disease, and then they compared the results.. Using a technique called whole-exome sequencing to analyze only the regions of DNA that make proteins, which make up about 2 percent of a persons genetic material, they began to home in on the genetic changes responsible for Kufs disease.. Its nearly impossible to tell when a single DNA variant causes a problem because there are about 3,000 unique variations in every person, Cruchaga says. But by comparing the DNA from the two related patients to the unaffected relative, we narrowed down the number of variants to 24.. Then, the researchers studied the DNA of more family members and winnowed the number of variants to three. Finally, they looked at DNA from people without the disease and found that two of the variants occurred in some healthy people without Kufs disease. That left only one causal variant.. The researchers also ...
https://www.healthcanal.com/genetics-birth-defects/23800-researchers-identify-gene-that-causes-rare-dementing-illness.html
Kufs DiseaseKufs Disease
The CLN6 gene (ceroid-lipofuscinosis, neuronal 6, late infantile, variant) is located on the long arm of chromosome 15 at position 23 (15q23). It provides instructions for making a protein that likely regulates the transport of certain proteins and fats from the endoplasmic reticulum to lysosomes. Based on this function, the CLN6 protein appears to help in the process of ridding cells of materials they no longer need. It is unclear how mutations in the CLN6 gene are involved in the buildup of lipopigments and the features of Kufs disease. Research suggests that CLN6 gene mutations that cause Kufs disease allow enough functional protein to be produced so that signs and symptoms of the disorder do not develop until adulthood. The presence of other proteins that compensate for the lack of CLN6 protein could also play a role in the appearance of symptoms in adulthood.. CLN6 gene; Sep 2013. Kufs disease, the major adult form of neuronal ceroid lipofuscinosis, caused by mutations in CLN6; May ...
https://flipper.diff.org/app/items/info/6213
Clinicopathological features of adult-onset neuronal intranuclear inclusion disease
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC5382941/
Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic...Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic...
TY - JOUR. T1 - Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer. AU - Wang, Donghai. AU - Peregrina, Karina. AU - Dhima, Elena. AU - Lin, Elaine Y.. AU - Mariadason, John M.. AU - Augenlicht, Leonard H.. PY - 2011/6/21. Y1 - 2011/6/21. N2 - Nutritional and genetic risk factors for intestinal tumors are additive on mouse tumor phenotype, establishing that diet and genetic factors impact risk by distinct combinatorial mechanisms. In a mouse model of dietary-induced sporadic small and large intestinal cancer in WT mice in which tumor etiology, lag, incidence, and frequency reflect ,90% of intestinal cancer in Western societies, dietary-induced risk altered gene expression profiles predominantly in villus cells of the histologically normal mucosa, in contrast to targeting of crypt cells by inheritance of an Apc 1638N allele or homozygous inactivation of p21 Waf1/cip1, and profiles induced by each risk factor ...
https://einstein.pure.elsevier.com/en/publications/paneth-cell-marker-expression-in-intestinal-villi-and-colon-crypt-2
J&J Agrees to Pay More in DePuy Hip Lawsuit Settlements - South Carolina Personal Injury Attorneys | Criminal Defense Lawyers -...J&J Agrees to Pay More in DePuy Hip Lawsuit Settlements - South Carolina Personal Injury Attorneys | Criminal Defense Lawyers -...
J&J has agreed to pay up to $420 million to settle additional DePuy Hip lawsuits. If you were injured by Deputy Hip, contact us today.
https://stromlaw.com/jj-agrees-to-pay-more-in-depuy-hip-lawsuit-settlements/
Ceroid Lipofuscinosis Neuronal 4A Autosomal Recessive
Adult-onset neuronal ceroid lipofuscinosis, also known as Kufs disease, is a neurodegenerative disorder without retinal involvement. There are 2 overlapping phenotypes: type A, characterized by progressive myoclonic epilepsy, and type B, characterized by dementia and a variety of motor-system signs (summary by {1:Arsov et al., 2011}). In general, the neuronal ceroid lipofuscinoses (NCL; CLN) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by the intracellular accumulation of autofluorescent lipopigment storage material in different patterns ultrastructurally. The clinical course includes progressive dementia, seizures, and progressive visual failure ({8:Mole et al., 2005}). The ultrastructural pattern of lipopigment in CLN4 comprises a mixed pattern of granular, curvilinear, and fingerprint profiles. ({8:Mole et al., 2005}). For a general phenotypic description and a discussion of genetic heterogeneity of CLN, see CLN1 ({256730 ...
http://diseaseinfosearch.org/Adult+neuronal+ceroid+lipofuscinosis/1254
Ceroid Lipofuscinosis Neuronal 4A Autosomal Recessive
Adult-onset neuronal ceroid lipofuscinosis, also known as Kufs disease, is a neurodegenerative disorder without retinal involvement. There are 2 overlapping phenotypes: type A, characterized by progressive myoclonic epilepsy, and type B, characterized by dementia and a variety of motor-system signs (summary by {1:Arsov et al., 2011}). In general, the neuronal ceroid lipofuscinoses (NCL; CLN) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by the intracellular accumulation of autofluorescent lipopigment storage material in different patterns ultrastructurally. The clinical course includes progressive dementia, seizures, and progressive visual failure ({8:Mole et al., 2005}). The ultrastructural pattern of lipopigment in CLN4 comprises a mixed pattern of granular, curvilinear, and fingerprint profiles. ({8:Mole et al., 2005}). For a general phenotypic description and a discussion of genetic heterogeneity of CLN, see CLN1 ({256730 ...
http://diseaseinfosearch.org/Kufs+Disease/1254
Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal...Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal...
Targeting EMT with a small-molecule inhibitor may be important in therapeutics, since it is increasingly being proven that EMT plays an integral role in cell migration, invasion, and metastasis (10, 11). Cat K and Cat S inhibitors have been tried in clinical trials, with many side effects and little progress (12, 13). However, no Cat L inhibitor has been evaluated in clinical trials. Our study was a preclinical mechanistic study to evaluate the feasibility of using the Cat L small-molecule inhibitor Z-FY-CHO in prostate and breast cancer cells that display EMT and are thus more aggressive. In this study, we showed that mesenchymal cells with high Snail expression displayed increased nuclear Cat L expression as well as increased expression of nuclear p110 and p90 isoforms of CUX1, which indicates higher Cat L activity within the nucleus since CUX1 is a substrate of Cat L in the nucleus (6). So far, only few substrates of nuclear cysteine peptidases have been identified, namely, CUX1, the histones ...
https://mcb.asm.org/content/37/5/e00297-16
EnzymicalsEnzymicals
The Ustilago maydis lipase UM03410 belongs to the mostly unexplored Candida antarctica lipase (CAL-A) subfamily. The two lipases with […] the highest identity are a lipase from Sporisorium reilianum and the prototypic CAL-A. In contrast to the other CAL-A-type lipases, this hypothetical U. maydis lipase is annotated to possess a prolonged N-terminus of unknown function. Here, we show for the first time the recombinant expression of two versions of lipase UM03410: the full-length form (lipUMf) and an N-terminally truncated form (lipUMs). For comparison to the prototype, the expression of recombinant CAL-A in E. coli was investigated. Although both forms of lipase UM03410 could be expressed functionally in E. coli, the N-terminally truncated form (lipUMs) demonstrated significantly higher activities towards p-nitrophenyl esters. The functional expression of the N-terminally truncated lipase was further optimized by the appropriate choice of the E. coli strain, lowering the cultivation ...
http://enzymicals.com/abstract_service.html
Differential Processing of Autoantigens in Lysosomes from Human Monocyte-Derived and Peripheral Blood Dendritic Cells | The...Differential Processing of Autoantigens in Lysosomes from Human Monocyte-Derived and Peripheral Blood Dendritic Cells | The...
MO-DC generated in vitro serve as a model type of DC to unravel the complex interactions among DC maturation, MHC class II peptide loading, and endocytic transport (3, 33, 34). The emerging picture suggests that endocytic protease activity is regulated by differential activity of the lysosomal ATPase during DC maturation (3). By analyzing lysosomal MBP processing at pH 5.0 in vitro, we have here mimicked the conditions present in the lysosomal compartment of DC in the activated state in vivo.. The MHC class II-associated proteolytic machinery is characterized by a hierarchical proteolytic cascade, where the initial step controls the efficiency of Ag processing, peptide presentation, and T cell activation (14). Different types of APC as well as primary cells and immortalized cell lines contain distinct activity patterns of endocytic proteases (11, 17, 31, 35, 36, 37) which might result in different processing pathways for a given Ag and hence in different selections of peptides presented. We here ...
https://www.jimmunol.org/content/175/9/5940?ijkey=59ddf579bad8461546cb1f0c567fad26bee7fc83&keytype2=tf_ipsecsha
Plus itPlus it
Squamous cell carcinoma (SCC) is a treatment-refractory subtype of human cancer arising from stratified epithelium of the skin, lung, esophagus, oropharynx and other tissues. A unifying feature of SCC is high-level expression of the p53 related protein p63 (TP63) in 80% of cases. The major p63 isoform expressed in SCC is ΔNp63α, an N-terminally truncated form which functions as a key SCC cell survival factor by mechanisms that are unclear. In this study we demonstrate that ΔNp63α associates with HDAC1 and HDAC2 to form an active transcriptional repressor complex that can be targeted to therapeutic advantage. Repression of pro-apoptotic Bcl-2 family member genes including PUMA by p63/HDAC is required for survival of SCC cells. Cisplatin chemotherapy, a mainstay of SCC treatment, promotes dissociation of p63 and HDAC from the PUMA promoter, leading to increased histone acetylation, PUMA activation and apoptosis. These effects are recapitulated upon targeting the p63/HDAC complex selectively ...
http://cancerres.aacrjournals.org/content/early/2011/04/27/0008-5472.CAN-11-0046
Human amniotic fluid stem cells have a potential to recover ovarian function in mice with chemotherapy-induced sterility | BMC...Human amniotic fluid stem cells have a potential to recover ovarian function in mice with chemotherapy-induced sterility | BMC...
Firstly, we analyzed hAFC samples for the expression of germ cell markers; in agreement to previous reports [11], we observed a consistently high expression of OCT4 and CD133. However, when we examined additional markers we did not observe expression of genes specific to germ cell differentiation. In this regard, it was reported that hAFCs had the ability to form embryoid bodies (EBs) when cultured under conditions without anti-differentiation factors and without contact to feeder cells. Moreover, the formation of such three-dimensional multicellular aggregates was accompanied by a decrease in stem cell marker expression and by the induction of differentiation into different cell lineages [23]. Hence herein hAFCs kept under a stem cell culture system yielded a high number of clones that when cultured in suspension without anti-differentiation factors, spontaneously formed multicellular EBs and harbored high differentiation potential. Moreover, when we cultured EBs in the presence of germ cell ...
https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-13-34
A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer...A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer...
Cancer stem cells (CSCs) are considered as the origin of tumor relapse. Here, we investigated the effects of Fructus Viticis total flavonoids (FVTF) on the characteristics of lung cancer stem-like cells (LCSLCs) derived from human small cell lung cancer NCI-H446 cell line and its potential mechanism. Human small cell lung cancer NCI-H446 cell line was cultured in vitro. The CD133+ cells were sorted from NCI-H446 cell line by magnetic separation. The suspended culture with stem cell-conditioned medium was used to amplify CD133+ sphere-forming cells (SFCs). The stem cell characteristics of CD133+ SFCs were evaluated using cell self-renewal capacity by tumor sphere formation assay, migration and invasion capacity by Transwell assay, tumorigenicity by xenograft model in nude mouse and cancer stem cell markers expression levels by western blot. The effects of FVTF on the properties of LCSLCs were examined by tumorsphere formation assay and transwell chamber assay. The expression level of p-Akt was determined
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-016-1341-4
2011 TOYOTA RAV4 RAV4 Base /i4 usados à venda no Japão BK145684 - BE FORWARD2011 TOYOTA RAV4 RAV4 Base /i4 usados à venda no Japão BK145684 - BE FORWARD
2011 TOYOTA RAV4 RAV4 Base /i4 usado para venda. Encontre um TOYOTA RAV4 usado acessível com o exportador No.1 japonês de carros usados BE FORWARD.
https://www.beforward.jp/pt/toyota/rav4/bk145684/id/2639454/
2023 Toyota RAV4 Hybrid Specs | ToyotaFD.com
2023 Toyota RAV4 Hybrid Release Date, Review, Specs - The impending 2023 Toyota RAV4 is providing numerous alternatives in every single office. Apart from the current gas model, RAV4 will even get the Best product. It will likely be an initial built-in connect-in hybrid version through the Japanese maker. RAV4 crossover can acquire quite a few ...
https://www.toyotafd.com/tag/2023-toyota-rav4-hybrid-specs/
2023 Toyota RAV4 Hybrid Review | ToyotaFD.com
2023 Toyota RAV4 Hybrid Release Date, Review, Specs - The impending 2023 Toyota RAV4 is providing numerous alternatives in every single office. Apart from the current gas model, RAV4 will even get the Best product. It will likely be an initial built-in connect-in hybrid version through the Japanese maker. RAV4 crossover can acquire quite a few ...
https://www.toyotafd.com/tag/2023-toyota-rav4-hybrid-review/
Car for sale 2021 Toyota Rav4 LE Milpitas 95035Car for sale 2021 Toyota Rav4 LE Milpitas 95035
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2015 Toyota RAV4 for Sale: 374 Cars from $11,995 - iSeeCars.com2015 Toyota RAV4 for Sale: 374 Cars from $11,995 - iSeeCars.com
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Asian Diabetic Corneas: A Study in Astigmatism - Journal of Asian HealthAsian Diabetic Corneas: A Study in Astigmatism - Journal of Asian Health
Purpose: Diabetic corneas have ultrastructural changes that can lead to dry eye, abnormal healing after trauma. The literature is sparse on the topic of Asian diabetics corneas with good Va and automated refractive keratometry readings. At our retina clinic in California, we retrospectively evaluated the keratometry readings of corneas of Diabetic patients in an Asian population. Are there external refractive or superficial keratometry differences in Asian Diabetic vs Asian Control eyes?. Methods: Corneal topography was performed using Topcon KR-8000PA Auto Kerato- Refractometer (Oakland, NJ) on patients as part of the refractive screening prior to dilation for evaluation of diabetic retinopathy ...
http://journalofasianhealth.com/asian-diabetic-corneas-a-study-in-astigmatism/
HCV is Detected in Liver of HCV Antibody-Positive But HCV RNA Negative Patients, so dont assume HCV has been cleared if viral...HCV is Detected in Liver of HCV Antibody-Positive But HCV RNA Negative Patients, so dont assume HCV has been cleared if viral...
Quantification of the 5 noncoding region of the genomic and antigenomic HCV RNA strands was done using a strand-specific real-time RT-PCR, with use of the thermostable enzyme Tth for the synthesis of cDNA at a high temperature. Thus, for the amplification of the genomic HCV RNA strand, cDNA was generated in 20 L of reaction mixture that contained the total RNA extracted from 200 uL of serum or 0.5 ug of total RNA from liver specimens or PBMC samples, 50 pmol/L antisense primer UTRLC2 (5-CAAGCACCCTATCAGGCAGT-3), 1 mmol/L MnCl2, 200 umol/L each deoxynucleotide triphosphate, 1X RT buffer (Applied Biosystems), and 5 U of Tth (Applied Biosystems). After 20 min at 65 C, the RT activity was inactivated by Mn2+ chelation with 8 uL of the 10X chelating buffer (Applied Biosystems), followed by heating at 95 C for 30 min. For amplification of antigenomic HCV RNA, cDNA was synthesized under the same conditions by the addition of 50 pmol/L sense primer UTRLC1 (5-CTTCACGCAGAAAGCGTCTA-3). Real-time PCR was ...
http://www.natap.org/2006/HCV/060806_01.htm
2021 Toyota RAV4 Prime: Primed and Ready for Electrified Traction - Toyota USA Newsroom2021 Toyota RAV4 Prime: Primed and Ready for Electrified Traction - Toyota USA Newsroom
PLANO, Texas (July 1, 2020) - The 2021 Toyota RAV4 Prime will break ground as the most powerful and quickest RAV4 ever, hitting dealerships this summer with a starting MSRP of $38,100. The RAV4s first-ever plug-in model has up to 302 horsepower with an ability to do 0-60 mph in a projected 5.7 seconds, which makes it the quickest four-door model in the Toyota lineup. But, it doesnt end there. The RAV4 Prime also has up to a manufacturer-estimated 42 miles on battery alone on a single charge, making it the highest EV range of any PHEV SUV on the market. The RAV4 Prime also has up to a manufacturer-estimated 94 combined MPGe. Even more, what sets RAV4 Prime apart is the standard Electronic On-Demand AWD.. How Does It Do That?. Toyota hybrids have for years demonstrated high performance with low fuel consumption, and now the 2021 RAV4 Prime makes one of the strongest cases yet. The RAV4 Prime uses a differently tuned version of the RAV4 Hybrids 2.5-liter four-cylinder Atkinson-cycle gas engine. ...
https://pressroom.toyota.com/2021-toyota-rav4-prime-primed-and-ready-for-electrified-traction/
Car for sale 2021 Toyota Rav4 Limited Milpitas 95035Car for sale 2021 Toyota Rav4 Limited Milpitas 95035
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RAV4 Hybrid (11)RAV4 Hybrid (11)
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Neuronal Ceroid Lipofuscinosis 13 via the CTSF Gene - PreventionGeneticsNeuronal Ceroid Lipofuscinosis 13 via the CTSF Gene - PreventionGenetics
The neuronal ceroid lipofuscinoses (NCLs) are inherited neurodegenerative lysosomal storage disorders caused by the accumulation of ceroid and lipofuscin in various cell types, mainly cells of the cerebral cortex, cerebellar cortex, and retina (Dyken et al. 1988; Williams and Mole 2012). Characteristic features at onset include clumsiness; deterioration of vision and psychomotor functions; seizures; and behavioral changes. Progression of clinical features results ultimately in total disability, blindness and premature death. Although NCL affects primarily children, age of onset of symptoms varies from infancy to adulthood. The incidence of NCL is variable and ranges from 1.3 to 7 per 100,000 (Mole and Williams 2013). However, it is more common in northern European populations, particularly Finland where the incidence may reach 1 in 12,500 individuals and a carrier frequency of 1 in 70 (Rider and Rider 1988). NCLs are clinically and genetically heterogeneous. A nomenclature and classification ...
https://www.preventiongenetics.com/testInfo.php?sel=test&val=Neuronal+Ceroid+Lipofuscinosis+13+via+the+CTSF+Gene
Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a...Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a...
Pyroglutamate amyloid-β peptides (pGlu-Aβ) are particularly pernicious forms of amyloid-β peptides (Aβ) present in Alzheimers disease (AD) brains. pGlu-Aβ peptides are N-terminally truncated forms of full-length Aβ peptides (flAβ(1-40/42) ) in which
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad131370
Tri-O-Plex Bar Whole Grain Protein Bar Chocolate Coconut 12 Bars Tri O Plex Trioplex Chef Jay - Compare Price and Reviews at...Tri-O-Plex Bar Whole Grain Protein Bar Chocolate Coconut 12 Bars Tri O Plex Trioplex Chef Jay - Compare Price and Reviews at...
VitaDigest offer Tri-O-Plex Bar Whole Grain Protein Bar Chocolate Coconut 12 Bars Tri O Plex Trioplex, Product Review For Chef Jay Formula and Information, Exclusive Reivews for Tri-O-Plex Bar Whole Grain Protein Bar Chocolate Coconut 12 Bars Tri O Plex Trioplex Chef Jay
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Finding cell linesFinding cell lines
I am trying to find if there is anyone in Brisbane, QLD, Australia who has the human osteosarcoma cell line U-2 OS in their lab. Any suggestions on how to get this information would be helpful Thank you Helen ...
http://www.bio.net/bionet/mm/methods/1997-August/060310.html
2002 toyota rav4 problems2002 toyota rav4 problems
A 2002 Toyota RAV4 Clogged Pistons:See 2005-2012 RAV4 - Common Problems. If it goes unchecked long enough, the transmission will need to be replaced. I called the Toyota dealership and they did nothing. We have 42 2002 Toyota RAV4 vehicles for sale that are reported accident free, 14 1-Owner cars, and 61 personal use cars. Encontre Toyota Rav 4x4 - Toyota RAV4 no MercadoLivre.com.br! Are you having problems with the engine of your Toyota RAV4? The RAV4 ranks 32nd in reliability out of 38 Toyota models.Its overall PainRank ™ of 33.73 is based on relative complaint analysis from 2362 owner complaints sent to CarComplaints.com over 27 model years.. Example: Bad Brakes, Toyota Recall, etc. The cruise light blinks continually every 20 seconds or so. Unsubscribe any time. In the following overview, you will find the most common problems for the Toyota RAV4, for which Toyota has announced a recall through the EU Rapex system. 27073228 Find the perfect used Toyota RAV4 in Seattle, WA by searching ...
https://landtmot.co.uk/buffalo-bayou-vwmek/4575b0-2002-toyota-rav4-problems
Compare Lexus UX vs 2021 Mini Cooper Countryman vs Toyota RAV4 | CarBuzzCompare Lexus UX vs 2021 Mini Cooper Countryman vs Toyota RAV4 | CarBuzz
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Used 2016 Toyota RAV4 For Sale | Batavia NY Near Medina JTMDFREV3GJ072288Used 2016 Toyota RAV4 For Sale | Batavia NY Near Medina JTMDFREV3GJ072288
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English Forum Switzerland - View Single Post - Is RAV different to Sozialhilfe (with relation to applying for a Swiss passport)English Forum Switzerland - View Single Post - Is RAV different to Sozialhilfe (with relation to applying for a Swiss passport)
Maybe someone could help to clarify RAV Job-Room, there is a web-portal where all the jobs are, and as I understood there are as well certain details
https://www.englishforum.ch/3182825-post19.html
소장자료상세 - 연세대학교 의학도서관소장자료상세 - 연세대학교 의학도서관
Introduction to Brain Tumor Stem Cells -- Isolation and Culture of Glioblastoma Brain Tumor Stem Cells -- Establishment and Culture of Patient-Derived Primary Medulloblastoma Cell Lines -- Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors -- Detecting Stem Cell Marker Expression Using the NanoString nCounter System -- Flow Cytometric Analysis of Brain Tumor Stem Cells -- In Vitro Self-Renewal Assays for Brain Tumor Stem Cells -- Differentiation of Brain Tumor Initiating Cells -- The Study of Brain Tumor Stem Cell Migration -- The Study of Brain Tumor Stem Cell Invasion -- Cell Cycle Dynamics in Glioma Cancer Stem Cells -- Embryonic Stem Cell Models of Human Brain Tumors -- Chromatin Immunoprecipitation (ChIP) Protocols for the Cancer and Developmental Biology Laboratory -- EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF -- Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells -- In Vitro Assays for ...
https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?rurl=%2Fcatalog%2Fsearch%2F%3Fquery%3DMedicine%2B%26Public_Health_%26si%3DTOTAL%26st%3DFRNT%26sortkey%3Dtitle%26sortorder%3DASC%26bk_0%26bk_3%3Djttj2019jttj%26&cid=CAT000000419725
Fluorescence Recovery after Photobleaching of Yellow Fluorescent Protein Tagged p62 in Aggresome-like Induced Structures |...Fluorescence Recovery after Photobleaching of Yellow Fluorescent Protein Tagged p62 in Aggresome-like Induced Structures |...
We describe a comprehensive and practical protocol for fluorescence recovery after photobleaching experiments with live cells. Although ...
https://www.jove.com/t/59288/fluorescence-recovery-after-photobleaching-yellow-fluorescent-protein
Todays Yahrtzeits and History - 13 Kislev | Matzav.comTodays Yahrtzeits and History - 13 Kislev | Matzav.com
Ravina berei Drav Huna (499 or 421 CE). Rosh Metivta of Sura. He, together with his teacher, Rav Ashi, collected and commented upon the Gemara of what would henceforth be known as the Talmud Bavli.. Rav Azariah min Haadumim, author of Meor Einayim (1577).. Rav Shlomo Zalman Yosef of Vyelpol (1857).. Rav Dov Ber of Levo, son on Rav Yisrael of Ruzhin (1875).. Rav Yisrael Aryeh of Premishlan (1890).. Rav Dov Ber Livshitz, Rav of Sardnik (1900). Rav Yisrael Taub of Modzhitz, author of Divrei Yisrael (1849-1920). He was the son of Rav Shmuel Eliyahu Taub of Zvolin (1888) and the grandson of Rav Yechezkel Taub of Kuzmir (1856), who was one of the students of the Chozeh of Lublin. He became the first Rebbe of Modzhitz and was succeeded by his son, Shaul Yedidya Elazer. Legend has it that in 1913 Taub composed a 30-minute negun while having his leg amputated without anesthesia.. Rav Yisrael Friedman, the second Tchortkover Rebbe (1934, 1933, or 1932). Rav Yechiel Michel Hager of Horodenka (1941). One ...
http://matzav.com/todays-yahrtzeits-and-history-13-kislev-3/
Toyota Rav4 Service And Repairs By Top Rated Mechanics | FiixToyota Rav4 Service And Repairs By Top Rated Mechanics | Fiix
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2022 Toyota Rav4 Hybrid | TOYOTA NEWS
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https://newtoyota2021.com/tag/2022-toyota-rav4-hybrid/
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Toyota RAV4 2,5 Hybrid H3 MDS 5d - 71 brugte til salg på BilbasenToyota RAV4 2,5 Hybrid H3 MDS 5d - 71 brugte til salg på Bilbasen
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2018 Toyota RAV4 LE | Philadelphia | 180869832018 Toyota RAV4 LE | Philadelphia | 18086983
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Toyota RAV4 For Sale in Decatur, GA - Nations Best AutosToyota RAV4 For Sale in Decatur, GA - Nations Best Autos
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Used 2010 Toyota RAV4 Features & Specs | EdmundsUsed 2010 Toyota RAV4 Features & Specs | Edmunds
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2019 Honda CR-V VS RAV4 | Fox Honda | Auburn, NY2019 Honda CR-V VS RAV4 | Fox Honda | Auburn, NY
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2021 Toyota RAV4 Trim Levels | Post Oak Toyota2021 Toyota RAV4 Trim Levels | Post Oak Toyota
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CathepsinCathepsin
... A (serine protease) Cathepsin B (cysteine protease) Cathepsin C (cysteine protease) Cathepsin D (aspartyl protease) ... Cathepsin H (cysteine protease) Cathepsin K (cysteine protease) Cathepsin L1 (cysteine protease) Cathepsin L2 (or V) (cysteine ... Cathepsin S (cysteine protease) Cathepsin W (cysteine proteinase) Cathepsin Z (or X) (cysteine protease) Cathepsins are ... Cathepsin K has also been shown to play a role in arthritis. Mouse cathepsin L is homologous to human cathepsin V. Mouse ...
https://en.wikipedia.org/wiki/Cathepsin
Cathepsin TCathepsin T
... (EC 3.4.22.24) is an enzyme. This enzyme catalyses the following chemical reaction: Interconversion of the three ... Cathepsin+T at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.22). ... Cathepsin Gohda E, Pitot HC (May 1981). "Purification and characterization of a new thiol proteinase from rat kidney". ... Pitot HC, Gohda E (1987). "Cathepsin T". Methods in Enzymology. 142: 279-89. doi:10.1016/s0076-6879(87)42038-7. PMID 2885716. ...
https://en.wikipedia.org/wiki/Cathepsin_T
Cathepsin FCathepsin F
... is a protein that in humans is encoded by the CTSF gene. Cysteine cathepsins are a family of cysteine proteases ... The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. ... Wex T, Levy B, Wex H, Brömme D (1999). "Human cathepsins F and W: A new subgroup of cathepsins". Biochem. Biophys. Res. Commun ... Wex T, Wex H, Brömme D (2000). "The human cathepsin F gene--a fusion product between an ancestral cathepsin and cystatin gene ...
https://en.wikipedia.org/wiki/Cathepsin_F
Cathepsin LCathepsin L
... may refer to: Cathepsin L1, a human protease enzyme encoded by the CTSL gene and known for its role in viral entry ... Cathepsin L2, a human protease enzyme encoded by the CTSV gene and also known as cathepsin V This disambiguation page lists ... articles associated with the title Cathepsin L. If an internal link led you here, you may wish to change the link to point ...
https://en.wikipedia.org/wiki/Cathepsin_L
Cathepsin WCathepsin W
"Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like ... Wex T, Levy B, Wex H, Brömme D (1999). "Human cathepsins F and W: A new subgroup of cathepsins". Biochem. Biophys. Res. Commun ... The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin ... 2003). "Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal ...
https://en.wikipedia.org/wiki/Cathepsin_W
Cathepsin SCathepsin S
... cathepsin S can be replaced by cathepsin F. Secreted cathepsin S cleaves some extracellular matrix (ECM) proteins. Cathepsin S ... "Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity". The Journal of ... In vitro, cathepsin S retains some enzyme activity in the presence of 3M urea. Cathepsin S is produced as a zymogen and is ... Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. Cathepsin S is a lysosomal enzyme that ...
https://en.wikipedia.org/wiki/Cathepsin_S
Cathepsin XCathepsin X
... (EC 3.4.18.1, cathepsin B2, cysteine-type carboxypeptidase, cathepsin IV, cathepsin Z, acid carboxypeptidase, ... Shows weak endopeptidase activity Cathepsin X is a cysteine cathepsin, a lysosomal cysteine peptidase of family C1 (papain ... Otto K, Riesenkönig H (February 1975). "Improved purification of cathepsin B1 and cathepsin B2". Biochimica et Biophysica Acta ... "On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1". Life Sciences. 17 ...
https://en.wikipedia.org/wiki/Cathepsin_X
Cathepsin DCathepsin D
... can also be found in the extracellular space and it is one of the few cathepsins, that shows some activity at ... Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to ... "Entrez Gene: CTSD cathepsin D". Barrett AJ (April 1970). "Cathepsin D. Purification of isoenzymes from human and chicken liver ... The optimum pH for cathepsin D in vitro is 4.5-5.0. Cathepsin-D is an aspartic protease that depends critically on protonation ...
https://en.wikipedia.org/wiki/Cathepsin_D
Cathepsin KCathepsin K
... is degraded by Cathepsin S, in a process referred to as Controlled Cathepsin Cannibalism. Cathepsin K expression is ... Cathepsin K has also been found to be over-expressed in glioblastoma. That the expression of cathepsin K is characteristic for ... Cathepsin K antibodies are marketed for research into expression of this enzyme by various cells. Merck had a cathepsin K ... Other cathepsin K inhibitors are in various stages of development. Medivir has a cathepsin K inhibitor, MIV-711 (L-006235), in ...
https://en.wikipedia.org/wiki/Cathepsin_K
Cathepsin ZCathepsin Z
... cathepsin C, cathepsin F, cathepsin H, cathepsin K, cathepsin L, cathepsin L2 or V, cathepsin O, cathepsin S, cathepsin Z, and ... Cathepsin Z, also called cathepsin X or cathepsin P, is a protein that in humans is encoded by the CTSZ gene. It is a member of ... As one of the 11 cathepsins, cathepsin Z contains distinctive features from others. Cathepsin Z has been reported involved in ... Cathepsin Z has an exposed integrin-binding Arg-Gly-Asp motif within the propeptide of the enzyme, through which cathepsin Z ...
https://en.wikipedia.org/wiki/Cathepsin_Z
Cathepsin L1Cathepsin L1
"Entrez Gene: CTSL1 cathepsin L1". Barrett AJ, Kirschke H (1981). "Cathepsin B, Cathepsin H, and cathepsin L". Methods in ... or by cathepsins (primarily cathepsin L) in endolysosomes. Hydroxychloroquine inhibits the action of cathepsin L in ... Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal ... Cathepsin L1 is a member of the Peptidase C1 (cathepsin) MEROPS family, which plays an important role in diverse processes ...
https://en.wikipedia.org/wiki/Cathepsin_L1
Cathepsin HCathepsin H
... is a protein that in humans is encoded by the CTSH gene. The protein encoded by this gene is a cysteine cathepsin, ... "Entrez Gene: CTSH cathepsin H". Sawicki G, Warwas M (1990). "Cathepsin H from human placenta". Acta Biochim. Pol. 36 (3-4): 343 ... 2003). "Expression of cathepsins B, H, K, L, and S during human fetal lung development". Dev. Dyn. 225 (1): 14-21. doi:10.1002/ ... 2001). "Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and ...
https://en.wikipedia.org/wiki/Cathepsin_H
Cathepsin GCathepsin G
... is one of those homologous protease that evolved from a common ancestor by gene duplication. Cathepsin G is a 255- ... An upregulation of cathepsin G was reported in studies of keratoconus. Cathepsin G has been found to interact with: SERPINB1 ... "Entrez Gene: CTSG cathepsin G". Shafer WM, Pohl J, Onunka VC, Bangalore N, Travis J (January 1991). "Human lysosomal cathepsin ... "Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets". The American Journal ...
https://en.wikipedia.org/wiki/Cathepsin_G
Cathepsin CCathepsin C
... prepro-cathepsin C) comprising signal peptides of 24 residues, pro-regions of 205 (rat cathepsin C) or 206 (human cathepsin C) ... Cathepsin C appears to be a central coordinator for activation of many serine proteases in immune/inflammatory cells. Cathepsin ... identical to the mature amino acid sequences of papain and a number of other cathepsins including cathepsins, B, H, K, L, and S ... "Entrez Gene: CTSC cathepsin C". Paris A, Strukelj B, Pungercar J, Renko M, Dolenc I, Turk V (Aug 1995). "Molecular cloning and ...
https://en.wikipedia.org/wiki/Cathepsin_C
Cathepsin zymographyCathepsin zymography
Cathepsin K detection by zymography Zymographic techniques for detection of cathepsins K, L, S, and V Zymography for detection ... Cathepsin zymography is a technique for quantifying enzymatic activity of the cathepsin family of cysteine proteases. It is ... While the proform of cathepsins are generally stable, once activated, proteases such as cathepsin K are vulnerable to ... After the renaturing period, the gel is then incubated in assay buffer to allow the now active cathepsins to proteolyze the ...
https://en.wikipedia.org/wiki/Cathepsin_zymography
Cathepsin L2Cathepsin L2
... , (EC 3.4.22.43, also known as cathepsin V or cathepsin U), is a protein encoded in humans by the CTSV gene. The ... "Entrez Gene: CTSL2 cathepsin L2". Brömme D, Li Z, Barnes M, Mehler E (February 1999). "Human cathepsin V functional expression ... 2006). "Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the ... 2007). "Inhibition of cathepsin L-like proteases by cathepsin V propeptide". Biol. Chem. 388 (5): 541-5. doi:10.1515/BC. ...
https://en.wikipedia.org/wiki/Cathepsin_L2
Cathepsin ACathepsin A
... is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA ... Cathepsin+A at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (Genes on human ... "Entrez Gene: CTSA cathepsin A". Mitchell, Richard Sheppard; Kumar, Vinay; Robbins, Stanley L.; Abbas, Abul K.; Fausto, Nelson ( ... Cathepsin A has been shown to interact with NEU1. GRCh38: Ensembl release 89: ENSG00000064601 - Ensembl, May 2017 GRCm38: ...
https://en.wikipedia.org/wiki/Cathepsin_A
Cathepsin OCathepsin O
... is an enzyme that in humans is encoded by the CTSO gene. Cathepsin O is a cysteine cathepsin, a cysteine protease ... "Entrez Gene: cathepsin O". Shi GP, Chapman HA, Bhairi SM, et al. (1995). "Molecular cloning of human cathepsin O, a novel ... 1994). "Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and ... "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231-4. doi:10.1006/geno ...
https://en.wikipedia.org/wiki/Cathepsin_O
Cathepsin ECathepsin E
... cathepsin D-like acid proteinase, cathepsin E-like acid proteinase, cathepsin D-type proteinase) is an enzyme. Cathepsin E is a ... The structure of Cathepsin E is very similar to those of Cathepsin D and BACE1, and all 3 have almost identical active site ... Along with renin and Cathepsin D, Cathepsin E is one of the only few aspartic proteases known to be made in human tissues other ... A distinguishing factor of Cathepsin E in comparison with the structure of Cathepsin D and BACE1 can be seen at the formation ...
https://en.wikipedia.org/wiki/Cathepsin_E
Cathepsin BCathepsin B
In humans, cathepsin B is encoded by the CTSB gene. Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, ... Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in ... Cathepsin B has been shown to interact with: CTSD CSTA, CSTB, and S100A10. Cathepsin B is inhibited by: Nitroxoline CA-074 ... Cathepsin B has been proposed as a potentially effective biomarker for a variety of cancers. Overexpression of cathepsin B is ...
https://en.wikipedia.org/wiki/Cathepsin_B
ChromatinChromatin
... , Histones & Cathepsin; PMAP The Proteolysis Map-animation Nature journal: recent chromatin publications and news ...
https://en.wikipedia.org/wiki/Chromatin
Polysulfated glycosaminoglycanPolysulfated glycosaminoglycan
... collagenases such as cathepsin B1; and hyaluronidase. PSGAG inhibits the synthesis of prostaglandin E2, which is released upon ...
https://en.wikipedia.org/wiki/Polysulfated_glycosaminoglycan
Carboxypeptidase CCarboxypeptidase C
Cathepsin A Breddam, K. (1986). "Serine carboxypeptidases. A review". Carlsberg Res. Commun. 51: 83-128. doi:10.1007/bf02907561 ... Miller JJ, Changaris DG, Levy RS (December 1992). "Purification, subunit structure and inhibitor profile of cathepsin A". ... Carboxypeptidase C (EC 3.4.16.5, carboxypeptidase Y, serine carboxypeptidase I, cathepsin A, lysosomal protective protein, ...
https://en.wikipedia.org/wiki/Carboxypeptidase_C
KeratinocyteKeratinocyte
Cathepsin E. TALE homeodomain transcription factors. Hydrocortisone. Since keratinocyte differentiation inhibits keratinocyte ... "The role of cathepsin E in terminal differentiation of keratinocytes". Biological Chemistry. 392 (6): 571-85. doi:10.1515/BC. ...
https://en.wikipedia.org/wiki/Keratinocyte
Batten diseaseBatten disease
Cathepsin D is involved in CLN10. DNA analysis can be used to help confirm the diagnosis of Batten disease. When the mutation ...
https://en.wikipedia.org/wiki/Batten_disease
MedivirMedivir
Miv-711 Cathepsin K inhibitor for osteoarthritis. Fast track (FDA) MALT1 "Swedish pharma firm Medivir partners Aragen Life ...
https://en.wikipedia.org/wiki/Medivir
Protease inhibitor (biology)Protease inhibitor (biology)
... these include cathepsin L, papain, and procaricain. It forms an alpha-helical domain that runs through the substrate-binding ...
https://en.wikipedia.org/wiki/Protease_inhibitor_(biology)
CUX1CUX1
"Cathepsins as transcriptional activators? Developmental Cell 2004, 6(5):610-1. Goulet B, and Nepveu A. "Complete and Limited ...
https://en.wikipedia.org/wiki/CUX1
HistolysainHistolysain
Lushbaugh WB, Hofbauer AF, Pittman FE (June 1985). "Entamoeba histolytica: purification of cathepsin B". Experimental ...
https://en.wikipedia.org/wiki/Histolysain
Cystatin BCystatin B
The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins L, H and B. The protein ... 1994). "Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status ... 1988). "Cathepsin D inactivates cysteine proteinase inhibitors, cystatins". Biochem. Biophys. Res. Commun. 154 (2): 765-72. doi ... Cystatin B has been shown to interact with Cathepsin B. GRCh38: Ensembl release 89: ENSG00000160213 - Ensembl, May 2017 GRCm38 ...
https://en.wikipedia.org/wiki/Cystatin_B
4P6E: Crystal Structure Of Human Cathepsin S Bound To A Non-covalent Inhibitor4P6E: Crystal Structure Of Human Cathepsin S Bound To A Non-covalent Inhibitor
CATHEPSIN SN-[(8r)-8-(Benzoylamino)-5,6,7,8-Tetrahydronaphthalen-2-Yl]-4-Methylpiperazine-1-CarboxamideSulfate Ion ... 4P6E: Crystal Structure Of Human Cathepsin S Bound To A Non-covalent Inhibitor. ...
https://www.ncbi.nlm.nih.gov/Structure/pdb/4P6E
Mouse Cathepsin F ELISA KitMouse Cathepsin F ELISA Kit
A Sandwich ELISA, Double Antibody ELISA kit for the detection of Mus musculus, Mouse, Cathepsin F, Ctsf, 3.4.22.41
https://www.gbiosciences.com/IT15382
Inhibiting Cathepsin G to Protect Against Photoaging and Infraaging | Cosmetics & ToiletriesInhibiting Cathepsin G to Protect Against Photoaging and Infra'aging | Cosmetics & Toiletries
Polygonum aviculare extract is a cathepsin G inhibitor, and is shown here to oppose photoaging and infraaging by improving ... Cathepsin G activity: The effect of Polygonum aviculare extracta on cathepsin G activity was evaluated using an enzymatic assay ... In addition, cathepsin G has been shown in vitro to degrade elastin into fragments that can be further processed by elastase.9 ... The cathepsin G inhibitor phosphonic acid served as a positive control. Results presented in Figure 2 show a neat inhibition of ...
https://www.cosmeticsandtoiletries.com/cosmetic-ingredients/actives/article/21835979/inhibiting-cathepsin-g-to-protect-against-photoaging-and-infraaging
Rat Cathepsin S (CTSS) ELISA kit | CSB-EL006204RA | CusabioRat Cathepsin S (CTSS) ELISA kit | CSB-EL006204RA | Cusabio
Rat Cathepsin S (CTSS) ELISA kit from Cusabio. Cat#: CSB-EL006204RA. US, UK & Europe Distribution. Online Order or Request ... Rat Cathepsin S (CTSS) ELISA kit , CSB-EL006204RA Cusabio Elisa Rat Cathepsin S (CTSS) ELISA kit , CSB-EL006204RA. (No reviews ... Recombinant Human Cathepsin S (CTSS) , CSB-EP006204HU , CusabioAlternative Name(s): Cathepsin S; CathepsinS; CATS_HUMAN; ... Human Cathepsin S (CTSS) ELISA Kit , CSB-E13722h , CusabioHuman Cathepsin S (CTSS) ELISA Kit is Available at Gentaur Genprice ...
https://joplink.net/rat-cathepsin-s-ctss-elisa-kit-csb-el006204ra/
Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State |...Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State |...
Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State. ... Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State ... Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State ... Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State ...
https://www.jneurosci.org/content/34/8/3013/tab-e-letters
Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 - DORASPeptide synthesis by recombinant Fasciola hepatica cathepsin L1 - DORAS
Ruth, Deborah M., McMahon, Gillian and Ó Fágáin, Ciarán (2006) Peptide synthesis by recombinant Fasciola hepatica cathepsin L1. ... fasciola hepatica cathepsin L1; recombinant; enzymatic peptide synthesis; cysteine proteinase;. Subjects:. Biological Sciences ... Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver ...
https://doras.dcu.ie/78/
Cathepsins - Proteases - Proteins and Enzymes - ProductsCathepsins - Proteases - Proteins and Enzymes - Products
... but it is currently unclear how cathepsins mediate apoptosis. Cathepsins are lysosomal enzymes that are also used as sensitive ... The cathepsin assays are simple, straightforward, and can be adapted to 96-well plate assays. Assay conditions have been ... BioVisions newly developed Cathepsin Activity Assay kits are fluorescence-based assays that utilize the preferred substrate ... Cell lysates or other samples that contain cathepsins will cleave the synthetic substrate to release free AFC. The released ...
https://www.biovision.com/products/proteins-and-enzymes/proteases/cathepsins.html
Ward, C., Kuehn, D., Burden, R.E., et al. (2010) Antibody targeting of cathepsin S inhibits angiogenesis and synergistically...Ward, C., Kuehn, D., Burden, R.E., et al. (2010) Antibody targeting of cathepsin S inhibits angiogenesis and synergistically...
2010) Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF. PLoS One, 5, Article ID ... TITLE: Antibody research targeting Cathepsin S for cancer therapy AUTHORS: Hang Fai Kwok KEYWORDS: Cathepsin S; Tumor; ... ABSTRACT: Cathepsin S is a cysteine protease highly expressed in many type of cancers including colorectal, prostate, breast, ... Immunoexpression of Cathepsin D and S100A4 Protein and Their Molecular Subtyptes in Canine Mammary Carcinomas ...
https://scirp.org/reference/referencespapers.aspx?referenceid=786161
Investigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease | European Respiratory SocietyInvestigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease | European Respiratory Society
Investigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease. Ryan Brown, Donna Small, ... Elevated levels of the cysteine protease cathepsin S (cat S) are found in cystic fibrosis (CF) lung secretions, however, the ... Investigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease ... Investigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease ...
https://erj.ersjournals.com/content/46/suppl_59/PA3903
Cathepsin G (human neutrophils), (purified) - BML-SE283 - Enzo Life SciencesCathepsin G (human neutrophils), (purified) - BML-SE283 - Enzo Life Sciences
Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis: J. Guo, et al.; Drug Des. Devel. Ther. 13 ... Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana ... Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019 ... Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem. 21, 2975 (2013 ...
https://www.enzolifesciences.com/BML-SE283/cathepsin-g-human-neutrophils-purified/
Human Cathepsin D ELISA Kit Price PicoKine® | BosterBioHuman Cathepsin D ELISA Kit Price PicoKine® | BosterBio
Human Cathepsin D ELISA Kit PicoKine™ (96 Tests). Quantitate Human CTSD in cell culture supernatants, cell lysates, serum ... More Cathepsin D Products. *Mouse Cathepsin D ELISA Kit PicoKine® (EK0673). *Human Cathepsin D PicoKine® Quick ELISA Kit ( ... Human Cathepsin D ELISA Kit PicoKine®. Cathepsin D ELISA kit for Human. Human Cathepsin D ELISA Kit PicoKine™ (96 Tests). ... Background of Cathepsin D. Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of ...
https://www.bosterbio.com/human-cathepsin-d-picokine-trade-elisa-kit-ek0672-boster.html
Two-step mechanism of inhibition of cathepsin B by cystatin C, due to the inhibitor displacing the occluding loop of the enzyme...Two-step mechanism of inhibition of cathepsin B by cystatin C, due to the inhibitor displacing the occluding loop of the enzyme...
Cysteine proteinase, Cysteine proteinase inhibitor, Cathepsin, Cystatin, Kinetics. in FEBS Letters. volume. 422. issue. 1. ... Two-step mechanism of inhibition of cathepsin B by cystatin C, due to the inhibitor displacing the occluding loop of the enzyme ... Stopped-flow kinetics showed that the inhibition of the lysosomal cysteine proteinase, cathepsin B, by its endogenous inhibitor ... Stopped-flow kinetics showed that the inhibition of the lysosomal cysteine proteinase, cathepsin B, by its endogenous inhibitor ...
https://lup.lub.lu.se/search/publication/1113877
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cellsExpression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
A selective inhibitor of cathepsin S blocked , 80% of this elastolytic activity. The presence of cathepsins K and S at sites of ... Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. ... Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. ... "Expression of the Elastolytic Cathepsins S and K in Human Atheroma and Regulation of Their Production in Smooth Muscle Cells." ...
https://dash.harvard.edu/handle/1/13506487?show=full
Cathepsin H, Human Liver | Athens Research & Technology
A more basic protein than Cathepsin B or L. Functions as both an aminopeptidase and endopeptidase. Cathepsin H, like cathepsin ... Gel Scan of Cathepsin H, Human Liver. This information is representative of the product ART prepares, but is not lot specific. ... "Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide ...
https://www.athensresearch.com/products/all/cathepsin-h-human-liver
Disruption of the Cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage...
BACKGROUND-: Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-profiling experiment that compared ... abstract = "BACKGROUND-: Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-profiling experiment that ... keywords = "Atherosclerosis, Cathepsins, Lipids, Pathology, Proteases",. author = "E. Lutgens and Lutgens, {S. P.M.} and Faber ... N2 - BACKGROUND-: Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-profiling experiment that ...
https://mayoclinic.pure.elsevier.com/en/publications/disruption-of-the-cathepsin-k-gene-reduces-atherosclerosis-progre
Cancer Markers - Cathepsin D - scrippslabs.comCancer Markers - Cathepsin D - scrippslabs.com
Cathepsin D. Cathepsin D is an estrogen-regulated, lysosomal acidic protease associated with tissue breakdown. Elevated levels ... Over-expression of Cathepsin D is also linked to tumorigenesis in prostate cancer and to aggressive forms of colorectal cancer ... In addition, Cathepsin D is associated with amyloid formation in Alzheimers plaques as is possibly linked to lung tissue ... Scripps Laboratories is a world-leading producer and supplier of purified human Cathepsin D. Products are prepared on-site and ...
https://scrippslabs.com/cathepsin-d-2/
Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system | Journal of...Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system | Journal of...
Cathepsin E (CtsE) is an important intermediate for antigen presentation and chemotaxis, but its role in the pathogenesis of ... Cathepsin E (CtsE) is an important intermediate for antigen presentation and chemotaxis, but its role in the pathogenesis of ... Cathepsin E (CtsE) is an aspartic protease mainly located at the endosomal compartment but also found in the endoplasmic ... Expression of Cathepsin E is downregulated in injured nerves from V30M animals. We have previously performed a transcriptomic ...
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0891-9
The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of...The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of...
Cathepsin D, but not Cathepsin L, also cleaved directly below the Ab hinge, releasing the F(ab)2. When constrained by the ... The Cathepsin L and Cathepsin D clipping motifs were related to sequences of neutral amino acids and the tertiary structure of ... ENZYMES: Cathepsin L-EC 3.4.22.15, Cathepsin D-EC 3.4.23.5. show less ... The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of ...
https://dspace.library.uu.nl/handle/1874/417445
Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K | BMC Research Notes | Full TextMatrix-metalloproteinase-9 is cleaved and activated by Cathepsin K | BMC Research Notes | Full Text
... treatment of recombinant proMMP-9 with recombinant cathepsin K (CTSK) at pH 5 yielded a fragment that corresponded to the ... Drake FH, Dodds RA, James IE, Connor JR, Debouck C, Richardson S et al (1996) Cathepsin K, but not cathepsins B, L, or S, is ... Lysosomal cysteine cathepsin (LCC) is a subgroup of the family of cathepsin proteases that requires an acidic environment for ... Activators of MMP-9 include MMP-2 [14, 15], MMP-3 [14, 16], MMP-7 [17], MMP-10 [18], MMP-13 [19], cathepsin G [20] and ...
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-1284-8
Cathepsin K (CTSK) Antibody | Abbexa LtdCathepsin K (CTSK) Antibody | Abbexa Ltd
Cathepsin K Antibody is a Mouse Monoclonal against Cathepsin K. ... Anti-Cathepsin O, Anti-Cathepsin O antibody, Cathepsin O ... Anti-Cathepsin X, Anti-Cathepsin X antibody, Cathepsin X antibody, Antibody against Cathepsin X ... Cathepsin K Antibody is a Mouse Monoclonal against Cathepsin K. Target. Cathepsin K (CTSK). ... CTS-K, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, Pycnodysostosis, Cathepsin O, Cathepsin X, Anti-CTS-K, Anti-CTS-K antibody, CTS-K ...
https://www.abbexa.com/cathepsin-k-antibody-6
InnoZyme™ Cathepsin B Activity Assay Kit, Fluorogenic | CBA001InnoZyme™ Cathepsin B Activity Assay Kit, Fluorogenic | CBA001
Cathepsin B Activity Assay Kit, Fluorogenic - Find MSDS or SDS, a COA, data sheets and more information. ... Table 2: Cathepsin B activity in cell lysates. Cathepsin B activity in five human cell line lysates as measured with Cathepsin ... Cathepsin B Inhibitor, Reduction Reagent, Cathepsin B Substrate, and Calibration Standard at -20°C. Control Cathepsin B(aliquot ... Cathepsin B Inhibitor, Reduction Reagent, Cathepsin B Substrate, and Calibration Standard at -20°C. Control Cathepsin B(aliquot ...
https://www.emdmillipore.com/PR/en/product/InnoZyme-Cathepsin-B-Activity-Assay-Kit-Fluorogenic,EMD_BIO-CBA001
Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization ...Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization ...
Cathepsin S (Cat S) expression was analyzed in human colon carcinoma and normal colon tissues. In vivo effects were evaluated ... Cathepsin S (Cat S), unlike the ubiquitous cathepsin B (Cat B) and cathepsin L (Cat L), exhibits a restricted tissue expression ... cathepsins are now recognized that cysteine proteases play pivotal roles in cancer progression[20]. Of the cysteine cathepsins ... Cathepsin S (Cat S) expression was analyzed in human colon carcinoma and normal colon tissues. In vivo effects were evaluated ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-43
Cathepsin K: boon or bale for atherosclerotic plaque stability?Cathepsin K: boon or bale for atherosclerotic plaque stability?
... , Cardiovascular Research, December 2008, European Society of ...
https://www.growkudos.com/publications/10.1093%25252Fcvr%25252Fcvn343/reader
Cathepsin S dominates autoantigen processing in human thymic dendritic cellsCathepsin S dominates autoantigen processing in human thymic dendritic cells
... Author: Stoeckle, Christina; Quecke, Paula; ... Cathepsin S dominates autoantigen processing in human thymic dendritic cells. DSpace Repository. Login ...
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/50952
Cathepsin | 组织蛋白酶 | 抑制剂 | MCECathepsin | 组织蛋白酶 | 抑制剂 | MCE
There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). ... Cathepsins are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide synthesis, among a ... Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the nucleophiles. ... Cathepsin X-IN-1 Inhibitor 98.81% Cathepsin X-IN-1 (compound 25) 是一种有效的 组织蛋白酶 X 抑制剂，IC50 为 7.13 µM。Cathepsin X-IN-1 降低 PC-3 细胞迁 ...
https://www.medchemexpress.cn/Targets/Cathepsin.html
Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics | Respiratory...Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics | Respiratory...
... a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases ... Dysregulated expression and activity of cathepsin S (CTSS), ... Plasma Cathepsin S and Cathepsin S/cystatin C ratios are ... CTSS is one of 11 cysteine cathepsin proteases, which is the largest cathepsin subclass. Cathepsins B, C, F, H, L, O, and X are ... Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. J ...
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01381-5
Cathepsin H › PeptaNovaCathepsin H › PeptaNova
SKU: 3113-v Category: Cathepsin and Thiol Protease Substrates Tags: Cathepsin H, substrate ...
https://peptanova.de/product-tag/cathepsin-h/
Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion | Breast...Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion | Breast...
A functional role for cathepsin B was confirmed by the ability of CA074, a cell impermeable and highly selective cathepsin B ... Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC. We examined expression of the ... Our study is the first to show that the proteolytic activity of cathepsin B and its co-expression with caveolin-1 contributes ... A statistically significant co-expression of cathepsin B and caveolin-1 was found in IBC patient biopsies, thus validating our ...
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3058
November | 2015 | Cathepsin K
Cathepsin K. Cathepsin K is a cysteine protease expressed predominantly in osteoclasts. Search. Main menu. Skip to primary ...
https://cathepsink.com/2015/11
Cathepsin D - MRM ProteomicsCathepsin D - MRM Proteomics
MRM Proteomics Inc. was established in 2010 as a spin-out company to commercialize the cutting-edge proteomics technologies, tools and know-how developed at the University of Victoria-Genome BC Proteomics Centre.. ...
https://mrmproteomics.com/product/cathepsin-d/
ProteasesInhibitorInhibitorsProteaseEnzymesPresence of cathepsinsCtsEProteinsFluorescenceAntibodiesAntibodyInhibitionPeptideTumorGeneAssayELISA KitXenopusExpressionRecombinantSubstrateMacrophagesSequencePathogenesisActivityHomoDegradationActiveDegrade elastinContrastInflammatory breastSignificantlyImmune system
Proteases9
  • There is growing recognition that alternative proteolytic enzymes such as the lysosomal cathepsin proteases may initiate or propagate proapoptotic signals, but it is currently unclear how cathepsins mediate apoptosis. (biovision.com)
  • Here, we explore the proteases Cathepsins L and D for forming protein fragments from three IgG1s, one IgG2, and one bispecific, knob-and-hole IgG1. (uu.nl)
  • Lysosomal cysteine cathepsin (LCC) is a subgroup of the family of cathepsin proteases that requires an acidic environment for optimal activation, and is found mainly in the acidic lysosomes where they participate in protein turnover and degradation of internalized ECM [ 25 ]. (biomedcentral.com)
  • CTSS is one of 11 cysteine cathepsin proteases, which is the largest cathepsin subclass. (biomedcentral.com)
  • Serine and cysteine cathepsin (Cts) proteases are an important class of intracellular and pericellular enzymes mediating multiple aspects of tumor development. (elsevier.com)
  • As well as activity in lysosomal protein degradation, cathepsin C also plays a key role in the activation of granule serine proteases in cytotoxic T cells, natural killer cells (granzymes A and B), mast cells (chymase and tryptase) and neutrophils (cathepsin G, neutrophil elastase, proteinase 3). (guidetoimmunopharmacology.org)
  • Cathepsins B and B-like proteases are identified in various species [ 3 ]. (ijbs.com)
  • Cathepsins B-like and L-like cysteine proteases are found in Caenorhabditis elegans [ 4 , 5 ]. (ijbs.com)
  • Moreover, several cathepsins and cathepsin-like proteases are revealed through functional and structural analyses in fishes, amphibians, reptiles, and birds in addition to mammals [ 11 ]. (ijbs.com)
Inhibitor6
  • 6, 7 Further, in one animal model of photoaging, a cathepsin G inhibitor prevented UVB-induced ECM degradation, suggesting activation of the enzyme by UVB as well. (cosmeticsandtoiletries.com)
  • Once activated, cathepsin G degrades fibronectin (FN) into fragments that induce and up-regulate the expression and activity of matrix metalloproteinase (MMP-1 and MMP-2) while simultaneously inhibiting the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1)-the natural inhibitor of MMPs. (cosmeticsandtoiletries.com)
  • Stopped-flow kinetics showed that the inhibition of the lysosomal cysteine proteinase, cathepsin B, by its endogenous inhibitor, cystatin C, occurs by a two-step mechanism, in which an initial, weak interaction is followed by a conformational change. (lu.se)
  • article{d5c1ff8e-0690-4d5e-85b5-097b38cc0bdd, abstract = {{Stopped-flow kinetics showed that the inhibition of the lysosomal cysteine proteinase, cathepsin B, by its endogenous inhibitor, cystatin C, occurs by a two-step mechanism, in which an initial, weak interaction is followed by a conformational change. (lu.se)
  • A functional role for cathepsin B was confirmed by the ability of CA074, a cell impermeable and highly selective cathepsin B inhibitor, to significantly reduce pericellular proteolysis and invasion by SUM149 cells. (biomedcentral.com)
  • 100 muM for cathepsin B). This compound could act as a new lead for the further development of improved inhibitors within this inhibitor type. (canada.ca)
Inhibitors9
  • Active cathepsins, cathepsin inhibitors and cathepsin antibodies are also available. (biovision.com)
  • The Calbiochem ® Cathepsin B Activity Assay Kit, Fluorogenic is designed to measure cathepsin B activity in tissues extracts and cell lysates, and for screening cathepsin B inhibitors. (emdmillipore.com)
  • Exploration of the P1 SAR of aldehyde cathepsin K inhibitors. (expasy.org)
  • By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were aromatic, bulky, hydrophobic amino-acid residues, especially leucine, and positively charged residues, especially arginine. (uni-bielefeld.de)
  • This random approach for the design of inhibitors was introduced to compensate for the inaccuracy induced by shifted docking of combinatorial compound collections at the active center of cathepsin L. Thereby, we obtained structurally defined pentapeptide amides which inhibited human cathepsin L at nanomolar concentrations. (uni-bielefeld.de)
  • Among the most potent novel inhibitors, one peptide, RKLLW-NH2, shares the amphiphilic character of the nonamer fragment VMNGLQNRK of the autoinhibitory, substrate-like, but reverse-binding prosegment of human cathepsin L which blocks the active center of the enzyme. (uni-bielefeld.de)
  • Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections", EUROPEAN JOURNAL OF BIOCHEMISTRY , vol. 267, 2000, pp. 5085-5092. (uni-bielefeld.de)
  • In a search for selective cathepsin L inhibitors as anticancer agents, a series of 2-cyanoprrolidine peptidomimetics, carrying a nitrile group as warhead, were designed. (canada.ca)
  • Inflammasome activation was confirmed using inhibitors of cathepsin B and Caspase-1. (cdc.gov)
Protease15
  • Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0-12.5% v/v acetonitrile at 37 °C. LC-MS detection indicated tripeptide formation after 10 min, continuing up to 5.5 h. (dcu.ie)
  • ABSTRACT: Cathepsin S is a cysteine protease highly expressed in many type of cancers including colorectal, prostate, breast, and glioblastoma's. (scirp.org)
  • Elevated levels of the cysteine protease cathepsin S (cat S) are found in cystic fibrosis (CF) lung secretions, however, the role of cat S in CF lung disease is unclear. (ersjournals.com)
  • Cathepsin G, a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation. (enzolifesciences.com)
  • BACKGROUND-: Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-profiling experiment that compared human early plaques, advanced stable plaques, and advanced atherosclerotic plaques containing a thrombus, where it was highly upregulated in advanced stable plaques. (elsevier.com)
  • Cathepsin D is an estrogen-regulated, lysosomal acidic protease associated with tissue breakdown. (scrippslabs.com)
  • Cathepsins are protease enzymes, categorized into multiple families. (medchemexpress.cn)
  • Cathepsins can be serine protease, cysteine protease, or aspartyl protease. (medchemexpress.cn)
  • Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number of conditions affecting the lungs. (biomedcentral.com)
  • In this review, we will focus on one cysteine protease in particular, cathepsin S (CTSS), and outline the research supporting its growing importance in pulmonary diseases and the potential of targeting of CTSS as a therapeutic option. (biomedcentral.com)
  • We examined expression of the cysteine protease cathepsin B and the serine protease urokinase plasminogen activator (uPA), its receptor uPAR and caveolin-1 in two IBC cell lines: SUM149 and SUM190. (biomedcentral.com)
  • The Magic Red Cathepsin K Kit uses a quick and easy method to analyze intracellular cathepsin K protease activity in whole living cells. (bio-rad-antibodies.com)
  • Cathepsin Magic Red Kits measure cathepsin K protease activity by detecting active cathepsins in whole, living cells. (bio-rad-antibodies.com)
  • Cathepsin C (CatC) is a lysosomal cysteine protease that is constitutively expressed at high levels in lung, kidney, liver and spleen. (guidetoimmunopharmacology.org)
  • Cathepsin L superfamily is a multifunctional cysteine protease enzyme and widely distributed in most animals. (ijbs.com)
Enzymes5
  • Cathepsins are lysosomal enzymes that are also used as sensitive markers in various toxicological investigations. (biovision.com)
  • Normal arteries contained little or no cathepsin K or S. In contrast, macrophages in atheroma contained abundant immunoreactive cathepsins K and S. Intimal smooth muscle cells (SMC), especially cells appearing to traverse the internal elastic laminae, also contained these enzymes. (harvard.edu)
  • The presence of cathepsins K and S at sites of vascular matrix remodeling and the ability of SMC and macrophages to use these enzymes to degrade elastin supports a role for elastolytic cathepsins in vessel wall remodeling and identifies novel therapeutic targets in regulating plaque stability. (harvard.edu)
  • ENZYMES: Cathepsin L-EC 3.4.22.15, Cathepsin D-EC 3.4.23.5. (uu.nl)
  • As multifunctional enzymes, cysteine cathepsins widely exist particularly in lysosomes. (ijbs.com)
Presence of cathepsins1
  • Instead, their methodology is based on a cell-permeable and non-cytotoxic reagent which is cleaved in the presence of cathepsins to produce a fluorescent product. (bio-rad-antibodies.com)
CtsE1
  • Cathepsin E (CtsE) is an important intermediate for antigen presentation and chemotaxis, but its role in the pathogenesis of FAP disease remains unknown. (biomedcentral.com)
Proteins3
  • Cathepsin H, like cathepsin L and B, is involved in the catabolism of proteins in the lysosomal system. (athensresearch.com)
  • Rodents contain 10 cysteine cathepsins and carry additional genes that express other cathepsins and cathepsin-like proteins [ 10 ]. (ijbs.com)
  • Western blotting showed increased Cox-2, Cyclin E, KLF4 and c-myc proteins and decreased expression of Cathepsin D. In addition, the KLF4 protein was higher in the chemically-induced cell strains compared to the spontaneously-occurring cell strains while COX-2 was higher in the spontaneously-occurring cell strains. (cdc.gov)
Fluorescence2
  • BioVision's newly developed Cathepsin Activity Assay kits are fluorescence-based assays that utilize the preferred substrate sequence for each cathepsin, labeled with AFC (amino-4-trifluoromethyl coumarin). (biovision.com)
  • The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields. (elsevier.com)
Antibodies2
  • IMSEAR at SEARO: Conformational studies of cathepsin B: interaction with specific antibodies. (who.int)
  • Bansal R, Singh S, Kidwai JR. Conformational studies of cathepsin B: interaction with specific antibodies. (who.int)
Antibody4
  • 2010) Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF. (scirp.org)
  • In recent years, antibody research specifically targeting Cathepsin S to block/inhibit tumorigenic effects were generated some positive preclinical data. (scirp.org)
  • This mini-review provides an overview of therapeutic antibody targeting Cathepsin S strategies in the last half decade, focusing on the rationale of cell-surface Cathepsin S targeted and their potential clinical application. (scirp.org)
  • Cathepsin K Antibody is a Mouse Monoclonal against Cathepsin K. (abbexa.com)
Inhibition1
  • The presence of this loop, which allows the enzyme to function as an exopeptidase, thus complicates the inhibition mechanism, rendering cathepsin B much less susceptible than other cysteine. (lu.se)
Peptide4
  • Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters. (athensresearch.com)
  • The Magic Red reagent contains a cathepsin K target sequence peptide (LR) 2 linked to a red (Cresyl Violet) fluorescent probe. (bio-rad-antibodies.com)
  • We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. (elsevier.com)
  • Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. (bioss.com.cn)
Tumor1
  • Expression array and real time PCR analysis demonstrated increased expression of the cell cycle inhibitory factor p16 and the apoptotic factor Cathepsin D in all of the tumor cell strains. (cdc.gov)
Gene4
  • Cathepsin D is a protein that in humans is encoded by the CTSD gene. (bosterbio.com)
  • Positive selection was the specific cause of differentiation of cathepsin L family genes, confirming that gene function variation after expansion events was related to interactions with the environment and adaptability. (ijbs.com)
  • Cathepsin C gene variants in aggressive periodontitis. (cdc.gov)
  • Identification of novel mutation in cathepsin C gene causing Papillon-Lefèvre Syndrome in Mexican patients. (cdc.gov)
Assay1
  • The effect of Polygonum aviculare extract a on cathepsin G activity was evaluated using an enzymatic assay. (cosmeticsandtoiletries.com)
ELISA Kit4
  • Rat Cathepsin S (CTSS) ELISA kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
  • CusabioHuman Cathepsin S (CTSS) ELISA Kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
  • CusabioRat Cathepsin L1 (CTSL1) ELISA kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
  • Human Cathepsin D ELISA Kit PicoKine™ (96 Tests). (bosterbio.com)
Xenopus1
  • Cathepsin L in zebrafish, cathepsins S and K in xenopus, and cathepsin L in mice and rats underwent evident tandem-repeat events. (ijbs.com)
Expression9
  • This study examined the expression of the potent elastases cathepsins S and K in human atheroma. (harvard.edu)
  • Over-expression of Cathepsin D is also linked to tumorigenesis in prostate cancer and to aggressive forms of colorectal cancer and lung adenocarcinoma. (scrippslabs.com)
  • Cathepsin S (Cat S) expression was analyzed in human colon carcinoma and normal colon tissues. (biomedcentral.com)
  • IBC patient biopsies were examined for expression of cathepsin B and caveolin-1. (biomedcentral.com)
  • A statistically significant co-expression of cathepsin B and caveolin-1 was found in IBC patient biopsies, thus validating our in vitro data. (biomedcentral.com)
  • Our study is the first to show that the proteolytic activity of cathepsin B and its co-expression with caveolin-1 contributes to the aggressiveness of IBC. (biomedcentral.com)
  • High Expression of Cathepsin E is associated with Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma. (cusabio.com)
  • In this work , we reveal the relationship between the expression of cathepsins and radioresistance in GBM. (bvsalud.org)
  • 18. Hie M, Shimono M, Fujii K, Tsukamoto I. Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats. (bvsalud.org)
Recombinant1
  • Also, treatment of recombinant proMMP-9 with recombinant cathepsin K (CTSK) at pH 5 yielded a fragment that corresponded to the molecular weight of active MMP-9, and showed MMP-9 activity. (biomedcentral.com)
Substrate1
  • Cell lysates or other samples that contain cathepsins will cleave the synthetic substrate to release free AFC. (biovision.com)
Macrophages1
  • Decreased activity of cathepsin E produced by decidual macrophages might be responsible for the induction of miscarriages in some recurrent miscarriage patients. (cusabio.com)
Sequence2
  • A DNA sequence encoding the Homo sapiens (Human) Cathepsin F, was expressed in the hosts and tags indicated. (enquirebio.com)
  • See the reference protein sequence for cathepsin E precursor (NP_001120469.1). (beds.ac.uk)
Pathogenesis1
  • Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema. (cusabio.com)
Activity3
  • Fifty plants initially were screened for activity against the cathepsin G enzyme to find the best botanical extract to inhibit its activity (data not shown). (cosmeticsandtoiletries.com)
  • Cultured human SMC displayed no immunoreactive cathepsins K and S and exhibited little or no elastolytic activity when incubated with insoluble elastin. (harvard.edu)
  • A comparative structure model of splice variant 2 was computed based on its alignment to the known structure of cathepsin E intermediate (Protein Data Bank code 1TZS) and used to rationalize its conformational properties and loss of activity. (cusabio.com)
Homo1
  • All 11 cysteine cathepsins are detected in Homo sapiens (human) through a bioinformatic study on the human genome [ 9 ]. (ijbs.com)
Degradation2
  • Cathepsin G has recently emerged as an important mediator of proteolytic ECM degradation in photoaging. (cosmeticsandtoiletries.com)
  • Downregulation of caveolin-1, the structural protein of caveolae, reduces the cell surface association of cathepsin B and decreases degradation of type IV collagen and invasion by the colon cancer cells, consistent with a functional role for caveolae-associated cathepsin B in invasion [ 12 ]. (biomedcentral.com)
Active3
  • SMC stimulated with the atheroma-associated cytokines IL-1beta or IFN-gamma secreted active cathepsin S and degraded substantial insoluble elastin (15-20 microg/10(6) cells/24 h). (harvard.edu)
  • Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC. (biomedcentral.com)
  • We observed that uPA, uPAR and enzymatically active cathepsin B were colocalized in caveolae fractions isolated from SUM149 cells. (biomedcentral.com)
Degrade elastin1
  • In addition, cathepsin G has been shown in vitro to degrade elastin into fragments that can be further processed by elastase. (cosmeticsandtoiletries.com)
Contrast1
  • Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp. (uni-bielefeld.de)
Inflammatory breast1
  • Cathepsin B: a potential prognostic marker for inflammatory breast cancer. (bvsalud.org)
Significantly1
  • Measurements of cell-associated enzyme activities showed that lactate dehydrogenase, acid phosphatase, and cathepsin D were significantly increased. (aai.org)
Immune system1
  • Emerging roles of cathepsin E in immune system cells and skin keratinocytes, and in host defense against cancer cells. (cusabio.com)

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