Cathelicidins. Medical search

Antimicrobial cationic peptides with a highly conserved amino terminal cathelin-like domain and a more variable carboxy terminal domain. They are initially synthesized as preproproteins and then cleaved. They are expressed in many tissues of humans and localized to EPITHELIAL CELLS. They kill nonviral pathogens by forming pores in membranes.

Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.

A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).

Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)

A species of gram-negative bacteria responsible for red mouth disease in rainbow trout (ONCORHYNCHUS MYKISS). The bacteria is a natural component of fresh water ecosystems in the United States and Canada.

Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Substances that reduce the growth or reproduction of BACTERIA.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

A pyrazine that is used therapeutically as an antitubercular agent.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.

Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

DEFENSINS found mainly in epithelial cells.

Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.

A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

A publication issued at stated, more or less regular, intervals.

"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)

A species of sheep, Ovis aries, descended from Near Eastern wild forms, especially mouflon.

Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

Diseases of domestic and mountain sheep of the genus Ovis.

A species of sheep, Ovis canadensis, characterized by massive brown horns. There are at least four subspecies and they are all endangered or threatened.

A species of the genus BRUCELLA which are pathogenic to SHEEP.

A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)

A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Rare congenital metabolism disorders of the urea cycle. The disorders are due to mutations that result in complete (neonatal onset) or partial (childhood or adult onset) inactivity of an enzyme, involved in the urea cycle. Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, NEONATAL HYPOTONIA; RESPIRATORY ALKALOSIS; HYPERAMMONEMIA; coma, and death. Survivors of the neonatal onset and childhood/adult onset disorders share common risks for ENCEPHALOPATHIES, METABOLIC, INBORN; and RESPIRATORY ALKALOSIS due to HYPERAMMONEMIA.

The optimal state of the mouth and normal functioning of the organs of the mouth without evidence of disease.

Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

A plant genus of the family RHAMNACEAE. Several species have been reclassified to the FRANGULA genus. It is often called buckthorn but should not be confused with other plants called that.

The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.

A genus of rubiaceous South American trees that yields the toxic CINCHONA ALKALOIDS from their bark; QUININE; QUINIDINE; chinconine, cinchonidine and others are used to treat MALARIA and CARDIAC ARRHYTHMIAS.

A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal.

Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.

Spindle-shaped cells with characteristic CONTRACTILE PROTEINS and structures that contribute to the WOUND HEALING process. They occur in GRANULATION TISSUE and also in pathological processes such as FIBROSIS.

Restoration of integrity to traumatized tissue.

The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.

Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. (1/295)

Recent studies suggest that the gene defect in cystic fibrosis (CF) leads to a breach in innate immunity. We describe a novel genetic strategy for reversing the CF-specific defect of antimicrobial activity by transferring a gene encoding a secreted cathelicidin peptide antibiotic into the airway epithelium grown in a human bronchial xenograft model. The airway surface fluid (ASF) from CF xenografts failed to kill Pseudomonas aeruginosa or Staphylococcus aureus. Partial reconstitution of CF transmembrane conductance regulator expression after adenovirus-mediated gene transfer restored the antimicrobial activity of ASF from CF xenografts to normal levels. Exposure of CF xenografts to an adenovirus expressing the human cathelicidin LL-37/hCAP-18 increased levels of this peptide in the ASF three- to fourfold above the normal concentrations, which were equivalent in ASF from CF and normal xenografts before gene transfer. The increase of LL-37 was sufficient to restore bacterial killing to normal levels. The data presented describe an alternative genetic approach to the treatment of CF based on enhanced expression of an endogenous antimicrobial peptide and provide strong evidence that expression of antimicrobial peptides indeed protects against bacterial infection. (+info)

The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. (2/295)

Peptide antibiotics are widespread in nature and, by providing a rapid first line of defense, may be key players in the innate immune system. Although epithelia are the main barriers shielding the internal environment from microorganisms, the role for peptide antibiotics in epithelial protection is unclear. We recently reported that the human cationic antimicrobial protein hCAP18, the precursor of the antimicrobial peptide called LL-37, is not expressed by normal human keratinocytes but is induced in various inflammatory skin disorders. In the present study we demonstrate that hCAP18 is consistently expressed at both mRNA and protein levels in squamous epithelia of the mouth, tongue, esophagus, cervix, and vagina in humans. The gene for hCAP18 contains promoter elements that are potentially regulated by interleukin-6, and our data further show a colocalization between interleukin-6 and hCAP18 expression in these tissues. Our finding that hCAP18 is widely produced in squamous epithelia suggests a role for this peptide in epithelial antimicrobial defense. Furthermore, colocalization with interleukin-6 indicates a potential local mechanism for the upregulation of hCAP18 at the epithelial surfaces. (+info)

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. (3/295)

The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic alpha-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Understanding its mode of action may assist in the development of antimicrobial agents mimicking those of the human immune system. In vitro studies revealed that LL-37 is cytotoxic to both bacterial and normal eukaryotic cells. To gain insight into the mechanism of its non-cell-selective cytotoxicity, we synthesized and structurally and functionally characterized LL-37, its N-terminal truncated form FF-33, and their fluorescent derivatives (which retained structure and activity). The results showed several differences, between LL-37 and other native antimicrobial peptides, that may shed light on its in vivo activities. Most interestingly, LL-37 exists in equilibrium between monomers and oligomers in solution at very low concentrations. Also, it is significantly resistant to proteolytic degradation in solution, and when bound to both zwitterionic (mimicking mammalian membranes) and negatively charged membranes (mimicking bacterial membranes). The results also showed a role for the N-terminus in proteolytic resistance and haemolytic activity, but not in antimicrobial activity. The LL-37 mode of action with negatively charged membranes suggests a detergent-like effect via a 'carpet-like' mechanism. However, the ability of LL-37 to oligomerize in zwitterionic membranes might suggest the formation of a transmembrane pore in normal eukaryotic cells. To examine this possibility we used polarized attenuated total reflectance Fourier-transform infrared spectroscopy and found that the peptide is predominantly alpha-helical and oriented nearly parallel with the surface of zwitterionic-lipid membranes. This result does not support the channel-forming hypothesis, but rather it supports the detergent-like effect. (+info)

The human antibacterial cathelicidin, hCAP-18, is bound to lipoproteins in plasma. (4/295)

Cathelicidins are a family of antibacterial and lipopolysaccharide-binding proteins. hCAP-18, the only human cathelicidin, is a major protein of the specific granules of human neutrophils. The plasma level of hCAP-18 is >20-fold higher than that of other specific granule proteins relative to their levels within circulating neutrophils. The aim of this study was to elucidate the background for this high plasma level of hCAP-18. Plasma was subjected to molecular sieve chromatography, and hCAP-18 was found in distinct high molecular mass fractions that coeluted with apolipoproteins A-I and B, respectively. The association of hCAP-18 with lipoproteins was validated by the cofractionation of hCAP-18 with lipoproteins using two different methods for isolation of lipoproteins from plasma. Furthermore, the level of hCAP-18 in delipidated plasma was <1% of that in normal plasma. Immunoprecipitation of very low, low, and high density lipoprotein particles with anti-apolipoprotein antibodies resulted in coprecipitation of hCAP-18. The binding of hCAP-18 to lipoproteins was mediated by the antibacterial C-terminal part of the protein. The binding of hCAP-18 to lipoproteins suggests that lipoproteins may play an important role as a reservoir of this antimicrobial protein. (+info)

Novel cathelicidins in horse leukocytes(1). (5/295)

Cathelicidins are precursors of defense peptides of the innate immunity and are widespread in mammals. Their structure comprises a conserved prepropiece and an antimicrobial domain that is structurally varied both intra- and inter-species. We investigated the complexity of the cathelicidin family in horse by a reverse transcription-PCR-based cloning strategy of myeloid mRNA and by Southern and Western analyses. Three novel cathelicidin sequences were deduced from bone marrow mRNA and designated equine cathelicidins eCATH-1, eCATH-2 and eCATH-3. Putative antimicrobial domains of 26, 27 and 40 residues with no significant sequence homology to other peptides were inferred at the C-terminus of the sequences. Southern analysis of genomic DNA using a probe based on the cathelicidin-conserved propiece revealed a polymorphic DNA region with several hybridization-positive fragments and suggested the presence of additional genes. A null eCATH-1 allele was also demonstrated with a frequency of 0.71 in the horse population analyzed and low amounts of eCATH-1-specific mRNA were found in myeloid cells of gene-positive animals. A Western analysis using antibodies to synthetic eCATH peptides revealed the presence of eCATH-2 and eCATH-3 propeptides, but not of eCATH-1-related polypeptides, in horse neutrophil granules and in the secretions of phorbol myristate acetate-stimulated neutrophils. These results thus suggest that eCATH-2 and eCATH-3 are functional genes, whereas eCATH-1 is unable to encode a polypeptide. (+info)

Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. (6/295)

Antimicrobial peptides, such as defensins or cathelicidins, are effector substances of the innate immune system and are thought to have antimicrobial properties that contribute to host defense. The evidence that vertebrate antimicrobial peptides contribute to innate immunity in vivo is based on their expression pattern and in vitro activity against microorganisms. The goal of this study was to investigate whether the overexpression of an antimicrobial peptide results in augmented protection against bacterial infection. C57BL/6 mice were given an adenovirus vector containing the cDNA for LL-37/hCAP-18, a human cathelicidin antimicrobial peptide. Mice treated with intratracheal LL-37/hCAP-18 vector had a lower bacterial load and a smaller inflammatory response than did untreated mice following pulmonary challenge with Pseudomonas aeruginosa PAO1. Systemic expression of LL-37/hCAP-18 after intravenous injection of recombinant adenovirus resulted in improved survival rates following intravenous injection of lipopolysaccharide with galactosamine or Escherichia coli CP9. In conclusion, the data demonstrate that expression of an antimicrobial peptide by gene transfer results in augmentation of the innate immune response, providing support for the hypothesis that vertebrate antimicrobial peptides protect against microorganisms in vivo. (+info)

SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. (7/295)

SMAP-29 is a cathelicidin-derived peptide deduced from sheep myeloid mRNA. The C-terminally amidated form of this peptide was chemically synthesized and shown to exert a potent antimicrobial activity. Antibiotic-resistant clinical isolates highly susceptible to this peptide include MRSA and VREF isolates, that are a major worldwide problem, and mucoid Pseudomonas aeruginosa associated with chronic respiratory inflammation in CF patients. In addition, SMAP-29 is also active against fungi, including Cryptococcus neoformans isolated from immunocompromised patients. SMAP-29 causes significant morphological alterations of the bacterial surfaces, as shown by scanning electron microscopy, and is also hemolytic against human, but not sheep erythrocytes. Its potent antimicrobial activity suggests that this peptide is an excellent candidate as a lead compound for the development of novel antiinfective agents. (+info)

Biological activities of lipopolysaccharides of Proteus spp. and their interactions with polymyxin B and an 18-kDa cationic antimicrobial protein (CAP18)-derived peptide. (8/295)

The saccharide constituents of lipopolysaccharides (LPS) of Proteus spp. vary with the strain and contain unique components about which little is known. The biological activities of LPS and lipid A from S- and R-forms of 10 Proteus strains were examined. LPS from all S-form Proteus strains was lethal to D-(+)-galactosamine (GalN)-loaded, LPS-responsive, C3H/HeN mice, but not to LPS-hypo-responsive C3H/HeJ mice. P. vulgaris 025 LPS evoked strong anaphylactoid reactions in N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP)-primed C3H/HeJ mice. LPS from S- and R-form Proteus strains induced production of nitric oxide (NO) and tumour necrosis factor (TNF) by macrophages isolated from C3H/HeN but not C3H/HeJ mice. Lipid A from Proteus strains also induced NO and TNF production, although lipid A was less potent than LPS. The effects of LPS were mainly dependent on CD14; LPS-induced NO and TNF production in CD14+ J774.1 cells was significantly greater than in CD14-J7.DEF.3 cells. All LPS from Proteus strains, and especially from P. vulgaris 025, exhibited higher anti-complementary activity than LPS from Escherichia coli or Pseudomonas aeruginosa. Polymyxin B inactivated proteus LPS in a dose-dependent manner, but these LPS preparations were more resistant to polymyxin B than E. coli LPS. CAP18(109-135), a granulocyte-derived peptide, inhibited proteus LPS endotoxicity only when the LPS:CAP18(109-135) ratio was appropriate, which suggests that CAP18(109-135) acts through a different mechanism than polymyxin B. The results indicate that LPS from Proteus spp. are potently endotoxic, but that the toxicity is different from that of LPS from E. coli or Salmonella spp. and even varies among different Proteus strains. The variation in biological activities among proteus LPS may be due to unique components within the respective LPS. (+info)

CathelicidinsEdit. In 2007, Richard Gallo and colleagues noticed that patients with rosacea had high levels of the ... Metronidazole is thought to act through anti-inflammatory mechanisms, while azelaic acid is thought to decrease cathelicidin ... "Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea". Nature Medicine. 13 (8): 975-80. ... antimicrobial peptide cathelicidin[12] and elevated levels of stratum corneum tryptic enzymes (SCTEs). Antibiotics have been ...

https://en.m.wikipedia.org/wiki/Rosacea

Cathelicidins, antimicrobial polypeptides found in lysosomes. Svendsen A (2000). "Lipase protein engineering". Biochim Biophys ...

https://en.wikipedia.org/wiki/Degradative_enzyme

Bowdish DM, Davidson DJ, Hancock RE (2006). "Immunomodulatory Properties of Defensins and Cathelicidins". CTMI. Current Topics ...

https://en.wikipedia.org/wiki/Alpha_defensin

Peel, E.; Cheng, Y.; Djordjevic, J. T.; Fox, S.; Sorrell, T. C.; Belov, K. (11 October 2016). "Cathelicidins in the Tasmanian ... Firstly, new research that proved antimicrobial peptides (called cathelicidins) in Tasmanian devil's milk can kill the ...

https://en.wikipedia.org/wiki/Katherine_Belov

Cathelicidin family. *Defensin family. Tachykinin peptides[edit]. Main article: Tachykinin peptides. *Substance P ...

https://en.wikipedia.org/wiki/Peptide

"Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin". FASEB J. 20 (12): 2068-80. doi: ...

https://en.wikipedia.org/wiki/KLK5

2006). "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin". FASEB J. 20 (12): 2068- ...

https://en.wikipedia.org/wiki/KLK7

He discovered that cathelicidin antimicrobial peptides(Cathelicidins) are present during wound repair. Subsequent work from his ... laboratory used molecular techniques to produce a knock out mouse that has shown how cathelicidin antimicrobials protect ...

https://en.wikipedia.org/wiki/Richard_Gallo

Metronidazole is thought to act through anti-inflammatory mechanisms, while azelaic acid is thought to decrease cathelicidin ... Richard Gallo and colleagues noticed that patients with rosacea had high levels of the antimicrobial peptide cathelicidin and ... "Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea". Nature Medicine. 13 (8): 975-80. ...

https://en.wikipedia.org/wiki/Rosacea

Proteases -Glycosidases Antimicrobial peptides Cathelicidin Hydrolase Molecular Cell Biology 6ed, Lodish et al. Biology portal ...

https://en.wikipedia.org/wiki/Acid_hydrolase

Cathelicidin Diptericin Aurein Copsin Peripheral membrane proteins Virtual colony count Ageitos JM, Sánchez-Pérez A, Calo-Mata ... Dürr UH, Sudheendra US, Ramamoorthy A (September 2006). "LL-37, the only human member of the cathelicidin family of ... cathelicidins, alpha- and beta-defensins, regIII peptides) Research has increased in recent years to develop artificially- ...

https://en.wikipedia.org/wiki/Antimicrobial_peptides

Subcutaneous fat also produces cathelicidin, which is a peptide that fights bacterial infections. DNA damage theory of ageing: ...

https://en.wikipedia.org/wiki/Ageing

Dombrowski Y, Schauber J (May 2012). "Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis". ...

https://en.wikipedia.org/wiki/Psoriasis

These studies have been expanded to include additional beta defensins, theta defensins, and the human cathelicidin LL-37 and ... "Structural and functional analysis of the pro-domain of human cathelicidin, LL-37". Biochemistry. 52 (9): 1547-58. doi:10.1021/ ...

https://en.wikipedia.org/wiki/Virtual_colony_count

Subcutaneous fat also produces cathelicidin, which is a peptide that fights bacterial infections. The term "skin" may also ...

https://en.wikipedia.org/wiki/Skin

Subcutaneous fat also produces cathelicidin, which is a peptide that fights bacterial infections. Anita Roberts, a molecular ...

https://en.wikipedia.org/wiki/Transforming_growth_factor_beta

The mechanism of action is thought to be through the inhibition of hyperactive protease activity that converts cathelicidin ... Reinholz, M.; Ruzicka, T.; Schauber, J. (2012). "Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin ...

https://en.wikipedia.org/wiki/Azelaic_acid

The skin creates antimicrobial peptides such as cathelicidins that control the proliferation of skin microbes. Cathelicidins ... A major factor controlling cathelicidin is vitamin D3.[29] Acidity[edit]. The superficial layers of the skin are naturally ... Conditions such as atopic dermatitis have been linked to the suppression in cathelicidin production.[28] In rosacea abnormal ... processing of cathelicidin cause inflammation. Psoriasis has been linked to self-DNA created from cathelicidin peptides that ...

https://en.wikipedia.org/wiki/Skin_flora

... beta-defensins and cathelicidins) and immunoglobulins. Terminally differentiated, superficial keratinocytes extrude the ...

https://en.wikipedia.org/wiki/Vaginal_epithelium

MSCs produce several antimicrobial peptides (AMPs) including human cathelicidin LL-37, β-defensins, lipocalin 2 and hepcidin. ...

https://en.wikipedia.org/wiki/Mesenchymal_stem_cell

These free fatty acids spur increased production of cathelicidin, HBD1, and HBD2, thus leading to further inflammation. This ...

https://en.wikipedia.org/wiki/Acne

Weiner, Daniel J.; Bucki, Robert; Janmey, Paul A. (June 2003). "The Antimicrobial Activity of the Cathelicidin LL37 Is ...

https://en.wikipedia.org/wiki/Plasma_gelsolin

Dürr UHN, Sudheendra US, Ramamoorthy A, LL-37, the only human member of the cathelicidin family of antimicrobial peptides, ...

https://en.wikipedia.org/wiki/Ayyalusamy_Ramamoorthy

... cathelicidin LL-37 and lysozyme". J. Dermatol. Sci. 40 (3): 157-68. doi:10.1016/j.jdermsci.2005.07.009. PMID 16150577. Cramer ...

https://en.wikipedia.org/wiki/SPACA3

Vitamin D promotes the production of cathelicidin, which helps to defend humans' bodies against fungal, bacterial, and viral ...

https://en.wikipedia.org/wiki/Light_skin

Subsequent analysis of the genome has led to the discovery of several cathelicidin peptides, which could also be used as ...

https://en.wikipedia.org/wiki/Tammar_wallaby

2001). "Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the ...

https://en.wikipedia.org/wiki/Lipopolysaccharide_binding_protein

Dombrowski (2012). "Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis". Experimental ...

https://en.m.wikipedia.org/wiki/Interleukin_17

Peroxisome Cathelicidin Antimicrobial peptides Innate immune system By convention similar cells in plants are called vacuoles, ...

https://en.wikipedia.org/wiki/Lysosome

"Entrez Gene: CAMP cathelicidin antimicrobial peptide".. *^ a b c d e Zanetti M (January 2004). "Cathelicidins, multifunctional ... Cathelicidins range in size from 12 to 80 amino acid residues and have a wide range of structures.[8] Most cathelicidins are ... Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins were originally found in ... Even larger cathelicidin peptides (39-80 amino acid residues) are also present. These larger cathelicidins display repetitive ...

https://en.wikipedia.org/wiki/Cathelicidin

Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Sci. Rep. 9, 1-12 (2019). ... Zanetti, M. Cathelicidins, multifunctional peptides of the innate immunity. J. Leukoc. Biol. 75, 39-48 (2004). ... The chicken cathelicidin, CATH-2 was synthesized and purified as described previously22. It is comprised of 26 amino acids - ... Cathelicidins: family of antimicrobial peptides. A review. Mol. Biol. Rep. 39, 10957-70 (2012). ...

https://www.nature.com/articles/s41598-020-66448-1?error=cookies_not_supported&code=3b0d3821-4ecf-4b6d-86aa-961067016a5b

1 Abstracts with Cathelicidin Induction Research. Filter by Study Type. In Vitro Study. ...

https://www.greenmedinfo.com/keyword/cathelicidin-induction

Shop a large selection of products and learn more about Biomatik CorporationHuman Cathelicidin Antimicrobial Peptide (CAMP) ... The Human Cathelicidin Antimicrobial Peptide (CAMP) ELISA Kit allows for quantitative determination in serum, plasma, tissue ...

https://www.fishersci.com/shop/products/elisa-kit-96t-per-kt-4537/501501208

A new role for cathelicidin in ulcerative colitis in mice.. Tai EK1, Wu WK, Wong HP, Lam EK, Yu L, Cho CH. ... Cathelicidin, an antimicrobial peptide of the innate immune system, modulates microbial growth, wound healing, and inflammation ... Our objective was to determine whether cathelicidin would exert a modulatory effect on the progression of IBD and, if so, ... The current study demonstrates for the first time that intrarectal administration of cathelicidin may be a novel therapeutic ...

https://www.ncbi.nlm.nih.gov/pubmed/17526772?dopt=Abstract

sp,P50415,CTHL3_SHEEP Cathelicidin-3 OS=Ovis aries OX=9940 GN=CATHL3 PE=1 SV=1 ...

https://www.uniprot.org/uniprot/P50415

Chicken cathelicidin-2 (CATH-2) has multiple immunomodulatory effects in vitro and the D-amino acid analog of this peptide has ... such as cathelicidins are multifunctional effectors of the innate immune system with both antimicrobial and pleiotropic ...

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198188

... Sun, Jia Jiangnan Univ, Ctr Food Safety & Nutr, Sch Food Sci ... However, how cathelicidins are expressed by beta cells and modulate beta-cell functions under steady-state or proinflammatory ... We find that cathelicidin-related antimicrobial peptide (CRAMP) is constitutively expressed by rat insulinoma b-cell clone INS- ... Cathelicidins are pleiotropic antimicrobial peptides largely described for innate antimicrobial defenses and, more recently, ...

http://uu.diva-portal.org/smash/record.jsf?pid=diva2:916205

Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in ... Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. Living in the ... and the importance of cathelicidins in the oral cavity. ... Cathelicidins are a group of oral antimicrobial peptides that ... Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their ...

http://www.mdpi.com/2218-273X/7/4/80

Ausgesuchte Qualitäts-Hersteller für Cathelicidin Antikörper. Hier bestellen. ... Monoklonale und polyklonale Cathelicidin Antikörper für viele Methoden. ... Cathelicidin-B1 , cathelicidin 2 , cathelicidin-2 , fowlicidin-2 , myeloid antimicrobial peptide 27 , antimicrobial peptide , ... anti-Cathelicidin (CAMP) Antikörper. Bezeichnung:. anti-Cathelicidin Antimicrobial Peptide Antikörper (CAMP). Auf www. ...

https://www.antikoerper-online.de/cellular-response-to-molecule-of-bacterial-origin-pathway-55/cathelicidin-antibody-37/

Although most cathelicidins possessed DNA complexing activity, only the alpha-helical BMAP cathelicidins and the cysteine-rich ... Although most cathelicidins possessed DNA complexing activity, only the alpha-helical BMAP cathelicidins and the cysteine-rich ... The present study aimed to investigate the ability of the bovine cathelicidins Indolicidin, Bac1, Bac5, BMAP-27, BMAP-28 and ... Collectively, the present data supports a role for certain bovine cathelicidins in helping the innate immune system to sense ...

https://www.frontiersin.org/articles/10.3389/fimmu.2017.00059/full

This study investigated the activity of cathelicidins against Candida albicans. The human cathelicidin LL-37, and mouse ... Cathelicidins have broad anti-microbial capacity and are important for host defense against skin infections by some bacterial ... The human cathelicidin LL-37, and mouse cathelicidin mCRAMP, killed C. albicans, but this fungicidal activity was dependent on ... Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection J Invest Dermatol. 2005 Jul; ...

https://pubmed.ncbi.nlm.nih.gov/15982310/?dopt=Abstract

Although cathelicidins are known to modulate activation by several TLR ligands, little is known about their influence on DNA- ... Importance of endosomal cathelicidin degradation to enhance DNA-induced chicken macrophage activation. Journal. The journal of ... Cathelicidins are essential in the protection against invading pathogens through both their direct antimicrobial activity and ... In this study, we explored the effects of cathelicidins on DNA-induced activation of chicken macrophages and elucidated the ...

http://dare.uva.nl/search?metis.record.id=512781

Compare and order Cathelicidin ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. Recommended ... Cathelicidin-B1 , cathelicidin 2 , cathelicidin-2 , fowlicidin-2 , myeloid antimicrobial peptide 27 , antimicrobial peptide , ... Bezeichner auf Proteinebene für Cathelicidin 18 kDa cationic antimicrobial protein , cathelicidin antimicrobial peptide , ... Search Cathelicidin ELISA Kits for other reactivities: Rabbit,. Guinea Pig,. Pig (Porcine),. Monkey,. Goat,. Dog (Canine),. Cow ...

https://www.antikoerper-online.de/cellular-response-to-molecule-of-bacterial-origin-pathway-55/cathelicidin-elisa-kit-38/

Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia Message Subject. (Your Name) has forwarded a page to you ... Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia. By Oliver Soehnlein, Sarawuth Wantha, Sakine Simsekyilmaz ... Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia. By Oliver Soehnlein, Sarawuth Wantha, Sakine Simsekyilmaz ...

https://stm.sciencemag.org/content/3/103/103ra98.full

The human cathelicidin, LL-37, and the murine cathelicidin, mCRAMP, demonstrated significant anti-viral activity in vivo, ... Cathelicidins have immunomodulatory and anti-viral effects, but their impact on influenza virus infection has not been ... We therefore evaluated the effect of cathelicidin peptides on disease caused by influenza A virus in mice. ... Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptides), which include cathelicidins and defensins, are key ...

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025333

To examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-(Cnlp+/+) and knockout (Cnlp−/−) mice underwent ... The ileal expression of cathelicidin was increased by three-fold after CLP, peaking at 4 h. Knockout of Cnlp significantly ... We also evaluated the prophylactic and therapeutic efficacies of vitamin D3 (an inducer of endogenous cathelicidin) in the CLP- ... Endogenous cathelicidin promotes intestinal barrier integrity accompanied by modulating the infiltration of neutrophils and ...

https://rd.springer.com/article/10.1186%2Fs13054-020-2754-5

Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-γ on APCs. Anastasia Nijnik, Jelena Pistolic, Aaron Wyatt, Sheena ... Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-γ on APCs ... Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-γ on APCs ... Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-γ on APCs ...

http://www.jimmunol.org/content/183/9/5788/tab-article-info

Bactericidal Activity of Mammalian Cathelicidin-Derived Peptides. Sue M. Travis, Norma N. Anderson, William R. Forsyth, Cesar ... Bactericidal Activity of Mammalian Cathelicidin-Derived Peptides. Sue M. Travis, Norma N. Anderson, William R. Forsyth, Cesar ... Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain.FEBS Lett.37419951 ... The first cathelicidin precursor to be described was rabbit CAP18 (20), and its mature peptide was shown to have broad-spectrum ...

https://iai.asm.org/content/68/5/2748

Antimicrobial Activity of a Cathelicidin Derivative Covalently Attached to Fluorous Surfaces A. M. McDermott; C. M. Santos; S. ... Purpose: : To compare the antimicrobial activity of LL-25, a truncated derivative of human cathelicidin LL-37, immobilized to ... A. M. McDermott, C. M. Santos, S. S. Kolar, A. Kumar, C. Cai; Antimicrobial Activity of a Cathelicidin Derivative Covalently ... Antimicrobial Activity of a Cathelicidin Derivative Covalently Attached to Fluorous Surfaces You will receive an email whenever ...

https://iovs.arvojournals.org/article.aspx?articleid=2372075

... CAMP. CAMP protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer ( ...

https://www.neuromics.com/PR27278

... Journal. Biological ...

http://dare.uva.nl/search?metis.record.id=325697

Cathelicidin oligomerization is not required for the growth inhibitory effects of B22.Cathelicidins are proposed to form higher ... Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats. Pediatr Surg Int 21:20-24. doi:10.1007/ ... Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis. Exp Dermatol 21:327-330. doi:10.1111/j. ... suggesting that cathelicidins have activities beyond perforating the membrane. Nanomolar concentrations of cathelicidins, ...

https://mbio.asm.org/content/10/5/e02021-19

1995) Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett. ... Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide. Robert Bals, Daniel J. Weiner, A. ... In humans, a number of defensins and one cathelicidin peptide have been described (1, 2, 4, 14, 17, 19). Members of these ... Cathelicidins are peptide antibiotics that are receiving increased attention. These peptides contain a highly conserved signal ...

https://iai.asm.org/content/67/11/6084?ijkey=e37cd9fd71605b2b2bd65c90784fc5dfd7ecb46b&keytype2=tf_ipsecsha

History of eczema herpeticum is associated with the inability to induce human beta-defensin (HBD)-2, HBD-3 and cathelicidin in ... HBD-3 and cathelicidin in the skin of patients with atopic dermatitis. British Journal of Dermatology, 163(3), 659 - 661. ...

https://www.rti.org/publication/history-eczema-herpeticum-associated-inability-induce-human-beta-defensin-hbd-2-hbd-3

Regulation of the cathelicidin hCAP18 by 1α,25(OH)2D3 and its effect on protein production. A, PBMC and MN of 10 donors were ... Effect of synthetic cathelicidin LL-37 on the growth of MTB. A, LL-37 led to a dose-dependent reduction in the growth of MTB in ... 1α,25(OH)2D3 up-regulates cathelicidin hCAP18, and the active peptide LL-37 decreases the growth of MTB. 1α,25(OH)2D3 is known ... The human antibacterial cathelicidin, hCAP-18, is bound to lipoproteins in plasma. J. Biol. Chem. 274: 22445-22451. ...

https://www.jimmunol.org/content/178/11/7190?ijkey=e83330a6f0faf65032c68d61cfd8f364ed46450d&keytype2=tf_ipsecsha

... the only human cathelicidin, is a cationic antimicrobial peptide with antibacterial and antifungal activity. LL-37 is released ... The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or ... LL-37, the only human cathelicidin, is a cationic antimicrobial peptide with antibacterial and antifungal activity. LL-37 is ...

https://pubmed.ncbi.nlm.nih.gov/23052388/?dopt=Abstract

Cathelicidins are bipartite molecules with an N-terminal cathelin domain and an antimicrobial C-terminal domain. Humans ... PR-39, a proline-rich porcine cathelicidin, has shown efficacy in limiting myocardial damage after experimental ischemia in ... LL-37 stimulates chemotaxis, acting via the formyl peptide-like receptor-1. The structurally diverse cathelicidin-derived ... apparently have only one cathelicidin gene. Its product, hCAP-18, is present in the secondary (specific) granules of ...

https://www.semanticscholar.org/paper/Cathelicidins%3A-a-family-of-endogenous-antimicrobial-Lehrer-Ganz/4c478aa55ae449e97aa9c56d8da70b14633422c0

... cathelicidin-2; CATH-2; fowlicidin-2; cathelicidin 2; Cathelicidin-B1; myeloid antimicrobial peptide 27 ... CAMP; cathelicidin antimicrobial peptide; Cnlp; MCLP; CAP18; Cramp; FALL39; cathelin-related antimicrobial peptide; CLP; ...

https://www.creative-biogene.com/symbolsearch_camp.html

Cathelicidin -related antimicrobial peptides are a family of polypeptides primarily stored in the lysosomes of macrophages and polymorphonuclear leukocytes (PMNs). (wikipedia.org)
[6] The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). (wikipedia.org)
Whilst the defensins share common structural features, cathelicidin-related peptides are highly heterogeneous. (wikipedia.org)
Cathelicidin peptides have been isolated from many different species of mammals . (wikipedia.org)
[8] Most cathelicidins are linear peptides with 23-37 amino acid residues, and fold into amphipathic α-helices . (wikipedia.org)
Even larger cathelicidin peptides (39-80 amino acid residues) are also present. (wikipedia.org)
The general rule of the mechanism triggering cathelicidin action, like that of other antimicrobial peptides, involves the disintegration (damaging and puncturing) of cell membranes of organisms toward which the peptide is active. (wikipedia.org)
Cathelicidins are pleiotropic antimicrobial peptides largely described for innate antimicrobial defenses and, more recently, immunomodulation. (diva-portal.org)
Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. (mdpi.com)
Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. (mdpi.com)
Cathelicidins encompass a family of cationic peptides characterized by antimicrobial activity and other functions, such as the ability to enhance the sensing of nucleic acids by the innate immune system. (frontiersin.org)
Cathelicidins comprise of a heterogeneous class of host defense peptides (HDP) also termed as antimicrobial peptides. (frontiersin.org)
A total of seven cathelicidin peptides were detected in granules of bovine granulocytes including the cysteine-rich bactenecin (Bac)1, also known as dodecapeptide ( 5 ), the proline-rich peptides Bac5 and Bac7 ( 6 ), the tryptophan-rich indolicidin ( 7 ), and the α-helical bovine myeloid antimicrobial peptides (BMAP)-27, BMAP-28 ( 8 ), and BMAP-34 ( 9 , 10 ). (frontiersin.org)
Cathelicidin represents one of the most important classes of antimicrobial peptides in mammals. (springer.com)
Endogenous antimicrobial peptides of the cathelicidin family contribute to innate immunity. (asm.org)
Solid-phase synthesis was employed to prepare linear antimicrobial peptides found in cathelicidins of five mammals: human (FALL39/LL37), rabbit (CAP18), mouse (mCRAMP), rat (rCRAMP), and sheep (SMAP29 and SMAP34). (asm.org)
Two broad classes of mammalian antibacterial peptides have been especially well studied: the cysteine-rich α- and β-defensins and various cathelicidins ( 6 , 13 , 22 , 26 , 27 , 41 , 42 ). (asm.org)
These cathelicidin-derived peptides kill bacteria by disrupting the bacterial membrane ( 28 ). (asm.org)
Our primary goal in this study was to identify peptides of the cathelicidin family having intrinsically high bactericidal activity toward Pseudomonas aeruginosa and Staphylococcus aureus . (asm.org)
We monitored peptide action in live bacterial cells over short time frames with single-cell resolution and found that the primary effect of cathelicidin peptides is to increase the production of oxidative molecules that cause cellular damage in Gram-positive and Gram-negative bacteria. (asm.org)
The cathelicidin family is a large and diverse collection of peptides that are released from mammalian cells by proteolysis of cathelin molecules in response to microbial infections ( 3 ). (asm.org)
Antimicrobial peptides, such as defensins or cathelicidins, are effector substances of the innate immune system and are thought to have antimicrobial properties that contribute to host defense. (asm.org)
Cathelicidins: a family of endogenous antimicrobial peptides. (semanticscholar.org)
Human cathelicidin LL-37 is best studied, and there has been a growing interest in designing new peptides based on LL-37. (springer.com)
Bovine and porcine cathelicidins are cleaved by elastase from the azurophil granules to yield the active antimicrobial peptides. (lu.se)
Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. (k-state.edu)
Offering one of the world's largest collections of catalog peptides, AnaSpec is pleased to introduce a wide range of structurally diverse cathelicidin peptides, some of which have not been commercially available until now. (pressreleaseforum.com)
Hybrid peptides were rationally designed through combination of functional amino acids in parent HDPs, including human cathelicidin (LL-37) and human beta-defensin (HBD)-1 to -3. (arvojournals.org)
The research peptide LL-37 is antimicrobial and the only known member of the cathelicidin family of peptides expressed in humans. (peptidesforresearch.com)
Cathelicidins (CATHLs) are small, cationic antimicrobial peptides that establish an early innate immune defense against infections in mammals. (tamu.edu)
Cathelicidins are small cationic peptides that possess broad-spectrum antimicrobial activity. (rosacea-support.org)
This article reviews the latest advances in the knowledge of cathelicidin antimicrobial peptides, with particular emphasis on their role in defense against invasive bacterial infection and associations with human disease conditions. (rosacea-support.org)
The deduced mature peptides cathelicidin-PR1 and cathelicidin-PR2 were composed of 29 and 25 residues, respectively. (bvsalud.org)
Novel cathelicidin-derived antimicrobial peptides from Equus a. (mysciencework.com)
Novel cathelicidin-derived antimicrobial peptides from Equus asinus. (mysciencework.com)
In the present study, EA-CATH1 and EA-CATH2 were identified from a constructed lung cDNA library of donkey (Equus asinus) as members of cathelicidin-derived antimicrobial peptides, using a nested PCR-based cloning strategy. (mysciencework.com)
We investigate the biological function of small cationic host defense peptides (cathelicidins and defensins) secreted by white blood cells and the epithelial cells in mammals. (cobolab.com)
Cathelicidins are small cationic antimicrobial peptides found in many species including primates, mammals, marsupials, birds and even more primitive vertebrates, such as the hagfish. (core.ac.uk)
2003). Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptides. (core.ac.uk)
2000). Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. (core.ac.uk)
We found that F2 exhibited synergistic antimicrobial activity with cathelicidin antimicrobial peptides and antibiotics that target the cell well and/or cell membrane, such as penicillin and daptomycin, in B. anthracis and drug-resistant strains of S. aureus. (elsevier.com)
Cathelicidin LL-37 is one important group of human antimicrobial peptides which exhibits antioxidant activity and its overexpression resists hyperoxia-induced oxidative stress. (elsevier.com)
Defensins and cathelicidins (LL-37) are main antimicrobial peptides (AMPs) from the innate disease fighting capability of the individual skin. (calcipotriol.net)
Among many antimicrobial peptides, individual -defensin (HBD) and cathelicidin will be the main peptides in mammalian epidermis and they could be induced by damage or irritation of your skin (1, 8-10). (calcipotriol.net)
Cathelicidin peptides, which facilitate immune recognition of released nucleic acids by promoting their access to intracellular TLR compartments, were rapidly induced in skin wounds and were sufficient but not necessary to stimulate pDC activation and type I IFN production. (rupress.org)
Cathelicidin gene expression closely paralleled pDC activation and cathelicidin peptides were found to be sufficient to induce IFN-α/β production by pDC in the skin. (rupress.org)
Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses. (unmc.edu)
and Hartshorn, Kevan L., "Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses. (unmc.edu)
Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. (biomedcentral.com)
In mammals, besides the mucosal epithelial cells lining the digestive, respiratory, and reproductive tracts, cathelicidins are most abundantly expressed in myeloid progenitor cells and stored in neutrophil granules as pro-peptides, which are converted into active forms by proteolytic cleavage upon degranulation. (biomedcentral.com)
Cathelicidins are antimicrobial peptides synthesized by humans and animals in response to various stimuli. (archivespsy.com)
Staphylococcus aureus exploits cathelicidin antimicrobial peptides produced during early pneumonia to promote staphylokinase-dependent fibrinolysis. (microbiologyresearch.org)

An investigation of human beta-defensins and cathelicidin expression i" by Remzi Karadag, Nurettin Bayram et al. (jefferson.edu)
An investigation of human beta-defensins and cathelicidin expression in patients with pterygium. (jefferson.edu)
PURPOSE: To investigate human beta-defensins (HBDs) and cathelicidin LL-37 (LL-37) expressions in patients with pterygium. (jefferson.edu)
Cathelicidins and β-defensins are two major families of HDPs in avian species. (mdpi.com)
Like their mammalian counterparts, avian cathelicidins and defensins are derived from either myeloid or epithelial origin expressed in a majority of tissues with broad-spectrum antibacterial and immune regulatory activities. (mdpi.com)
For example, patients with atopic dermatitis suppress expression of cathelicidins and defensins and thus are more susceptible to skin infections. (rosacea-support.org)
Using reverse transcriptasepolymerase chain reaction of milk cell RNA from a sample of platypus milk, we found no evidence for the expression of cathelicidins or defensins in the milk. (edu.au)
The main focus is to discover the underlying mechanisms of cathelicidins and defensins which show to have an important beneficial role in tissue homeostasis, including regulation of harmful inflammation and control of microbial pathogens. (cobolab.com)
The goal is to advance cathelicidins and defensins (either synthetic derivatives or induction of endogenous production) as natural, efficacious and cost-effective alternatives to current treatments that could reduce the use of conventional antibiotics. (cobolab.com)

This abstract tells us that the inflammation and extra blood vessels associated with exposure to the sun (specifically the UVB band of radiation) are enhanced in the presence of cathelicidin LL-37. (rosacea-support.org)

C57BL/6 mice were given an adenovirus vector containing the cDNA for LL-37/hCAP-18, a human cathelicidin antimicrobial peptide. (asm.org)
The aim of this study is to analyze the impact of overexpression of a naturally occurring human antimicrobial cathelicidin peptide (LL-37/hCAP-18) in murine models of infection and sepsis. (asm.org)
By contrast, 1α,25(OH) 2 D 3 strongly up-regulated the cathelicidin hCAP-18 gene, and some hCAP-18 polypeptide colocalized with CD14 in 1α,25(OH) 2 D 3 stimulated PBMC, although no detectable LL-37 peptide was found in supernatants from similar 1α,25(OH) 2 D 3 -stimulated PBMC cultures. (jimmunol.org)
The aim of this study was to identify the physiological setting for cleavage of the only human cathelicidin, hCAP-18, to liberate the antibacterial and cytotoxic peptide LL-37 and to identify the protease responsible for this cleavage. (lu.se)
mCRAMP was first isolated from bone marrow and has been the focus of investigation due to the homology in gene sequence, structure, and protein processing that it shares with the human cathelicidin, LL-37/hCAP-18 [ 11 ]. (biomedcentral.com)

However, following injury or inflammatory skin diseases such as psoriasis and rosacea, expression of the cathelicidin antimicrobial peptide LL37 breaks tolerance to self-nucleic acids and triggers inflammation. (rosaceagroup.org)
The research peptide LL37 is a synthetic version of the human form of cathelicidin LL-37. (peptidesforresearch.com)
We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures. (meta.org)
Cathelicidin LL37, an endogenous antimicrobial peptide, has recently been implicated in the pathogenesis of autoimmune diseases. (biomedcentral.com)
The serum levels of cathelicidin LL37 and IFN-α were both measured by ELISA, and the clinical and serological parameters were assessed according to routine procedures. (biomedcentral.com)

Zaiou, Gallo: Cathelicidins, essential gene-encoded mammalian antibiotics. (antikoerper-online.de)
Humans apparently have only one cathelicidin gene. (semanticscholar.org)
Additionally, no differences in cathelicidin killing as compared to the MRSA252 WT strain were observed for a blaZ mutant in this strain background (data not shown) further ensuring that the cathelicidin susceptibility phenotype of the blaI mutant was specific to the blaI gene. (nih.gov)
Bals R, Weiner DJ, Meegalla RL, Wilson JM (1999) Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. (springer.com)
AzA directly inhibited KLK5 in cultured keratinocytes and gene expression of KLK5, Toll-like receptor-2, and cathelicidin in mouse skin. (em-consulte.com)
In this study, we demonstrate that cyclic stretch of the human bronchial epithelial cell lines VA10 and BCi NS 1.1 leads to down-regulation of cathelicidin antimicrobial peptide ( CAMP ) gene expression. (peerj.com)
Gene targeting and molecular analysis by our laboratory has shown cathelicidins are critical to mammalian immunity and are associated with human disease. (rosacea-support.org)
2007). Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide. (core.ac.uk)
2005). Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (core.ac.uk)
The aim of the study was to analyze acute phase protein and cathelicidin gene responses to small ruminant lentivirus (SRLV) infection in goats. (biomedcentral.com)

Cathelicidins are AMPs that preferentially kill Gram-negative bacteria in vitro , purportedly by assembling into higher-order structures that perforate the membrane. (asm.org)
We next performed killing kinetics with cathelicidin AMPs. (nih.gov)
Since not much is known about the impact of efflux pumps on the susceptibility of Gram-positive bacteria to AMPs, especially to the cathelicidins, the aim of this study was to analyze whether Staphylococcus aureus can use efflux pumps to resist the antimicrobial effects of cathelicidins derived from different animal species (human, mouse, rabbit or cattle). (fu-berlin.de)
Cathelicidins are a major family of AMPs in vertebrate animals including chickens. (biomedcentral.com)
AMPs including cathelicidins have been detected in the meconium and feces of human infants [ 15 ], and elevated levels of cathelicidin have been noticed in the infants associated with respiratory infections [ 16 ], suggestive of the role of cathelicidins and other AMPs in early host defense of humans. (biomedcentral.com)

Cathelicidins are present in humans and other mammals as well. (mdpi.com)
Interestingly, cattle possess all classes of cathelicidins recognized in higher vertebrates, whereas in humans only LL-37 was described. (frontiersin.org)
Recent evidence suggests that cathelicidins (LL-37 in humans and mCRAMP in mice) may modulate responses in inflammation, apoptosis and angiogenesis. (grantome.com)
The only one known member of the cathelicidin family expressed in humans is LL-37. (archivespsy.com)

We evaluated the potential for a synthetic cathelicidin, the mouse cathelin-related antimicrobial peptide (mCRAMP), to prevent the initiation and promote the healing of lesions from inflammatory colitis that was experimentally induced in mice with dextran sulfate sodium (DSS). (nih.gov)
The human cathelicidin LL-37, and mouse cathelicidin mCRAMP, killed C. albicans, but this fungicidal activity was dependent on culture conditions. (nih.gov)
C. albicans also induced an increase in the expression of cathelicidin in mouse skin, but this induction did not confer systemic or subcutaneous resistance as mCRAMP-deficient mice were not more susceptible to C. albicans in blood-killing assays or in an intradermal infection model. (nih.gov)
Moreover, short-term administration of mouse cathelicidin (mCRAMP) relieves many aspects of trinitrobenzene sulphonic acid- induced colitis in mice. (grantome.com)
For this purpose the minimal inhibitory concentrations (MICs) of S. aureus field isolates for the cathelicidins LL-37, mCRAMP, CAP18, BMAP-27 and BMAP-28 in the presence and absence of different efflux pump inhibitors were determined. (fu-berlin.de)
Cathelicidins are a class of antimicrobial peptide, and the murine cathelicidin-related antimicrobial peptide (mCRAMP) has been demonstrated in vitro to impair Salmonella enterica serovar Typhimurium proliferation. (biomedcentral.com)

Patients with rosacea have elevated levels of cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs). (wikipedia.org)
Bac5, Bac7 Frogs: cathelicidin-AL (found in Amolops loloensis) Chickens: Four cathelicidins, fowlicidins 1,2,3 and cathelicidin Beta-1 Tasmanian Devil: Saha-CATH5 Salmonids: CATH1 and CATH2 Patients with rosacea have elevated levels of cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs). (wikipedia.org)
Cathelicidin has been in the rosacea news since around 2002, gaining publicity because of the discoveries like the fact that rosacea sufferers have abnormally high levels of cathelicidin in their facial skin. (rosacea-support.org)

The first cathelicidin precursor to be described was rabbit CAP18 ( 20 ), and its mature peptide was shown to have broad-spectrum bactericidal activity ( 19 ). (asm.org)
This chapter describes the alternative processing of the human cathelicidin precursor, protease digestion, and lab cutting of LL-37. (springer.com)
We assayed the in vitro antibacterial activities of hCLD, LL-37 and the precursor form, pro-cathelicidin (also known as hCAP18), and we found that the unprocessed protein inhibited the growth of Gramnegative bacteria with efficiencies comparable to the mature peptide, LL-37. (k-state.edu)

[18] [19] Cathelicidin rapidly destroys the lipoprotein membranes of microbes enveloped in phagosomes after fusion with lysosomes in macrophages . (wikipedia.org)
Cathelicidins are mostly found in neutrophils, monocytes, mast cells, dendritic cells and macrophages after activation by bacteria, viruses, fungi, parasites or the hormone 1,25-D, which is the hormonally active form of vitamin D. They have been found in some other cells, including epithelial cells and human keratinocytes. (wikipedia.org)
Cathelicidin rapidly destroys the lipoprotein membranes of microbes enveloped in phagosomes after fusion with lysosomes in macrophages. (wikipedia.org)
In this study, we explored the effects of cathelicidins on DNA-induced activation of chicken macrophages and elucidated the intracellular processes underlying these effects. (uva.nl)
Our results show that chicken cathelicidin (CATH)-2 strongly enhances DNA-induced activation of both chicken and mammalian macrophages because of enhanced endocytosis of DNA-CATH-2 complexes. (uva.nl)
Endogenous cathelicidin promotes intestinal barrier integrity accompanied by modulating the infiltration of neutrophils and macrophages in polymicrobial sepsis. (springer.com)
We concluded that cathelicidin LL-37 enhances MAP clearance into macrophages and suppressed production of tissue-damaging inflammatory cytokines. (utmb.edu)

[5] Cathelicidins serve a critical role in mammalian innate immune defense against invasive bacterial infection. (wikipedia.org)
Cathelicidins have broad anti-microbial capacity and are important for host defense against skin infections by some bacterial and viral pathogens. (nih.gov)
These observations underline the importance of cathelicidins in sensing bacterial products and regulating immune responses. (uva.nl)
We propose that that the primary effect of cathelicidins is to induce the production of ROS that damage bacterial molecules, leading to slowed growth or cell death. (asm.org)
Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium. (cobolab.com)
The cationic peptide cathelicidin, LL-37, is an important part of the early innate immune response to bacterial infection. (beds.ac.uk)
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. (microbiologyresearch.org)

We also evaluated the prophylactic and therapeutic efficacies of vitamin D3 (an inducer of endogenous cathelicidin) in the CLP-induced murine polymicrobial sepsis model. (springer.com)
Compared to their respective S. aureus Newman and MRSA252 WT strains, the blaI mutants were found to be more susceptible to the murine cathelicidin CRAMP and human LL-37 with their CFU concentrations being approximately 0.5 logs lower compared to the respective WT strains after 1-2 hours of co-incubation with the cathelicidins (Fig 2A-2D). (nih.gov)

Although most cathelicidins possessed DNA complexing activity, only the alpha-helical BMAP cathelicidins and the cysteine-rich disulfide-bridged Bac1 were able to enhance the sensing of nucleic acids by primary epithelial cells. (frontiersin.org)
Therefore, we hypothesize that the inflamed colon releases molecules that stimulate cathelicidin expression from epithelial cells and/or immune cells but these moderately increased cathelicidin levels in the intestine may not be sufficient to counteract severe inflammation. (grantome.com)
Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production. (cobolab.com)
2000). LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. (core.ac.uk)
We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D 3 in a lung epithelial cell line. (biomedcentral.com)
In a search for effective therapeutics, our objective was to determine whether human cathelicidin LL-37, a small peptide secreted by leuckocytes and epithelial cells, enhances the macrophage ability to clear MAP infection. (utmb.edu)

Since their discovery over a decade ago, cathelicidins have been speculated to function within the innate immune system, contributing to a first line of host defense against an array of microorganisms. (rosacea-support.org)
As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. (biomedcentral.com)
Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. (biomedcentral.com)
Cathelicidin (LL-37) and human β-defensin 1 (hBD-1) are important components of the innate defense in the urinary tract. (forskningsdatabasen.dk)
Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. (archivespsy.com)

Vitamin D up-regulates genetic expression of cathelicidin, which exhibits broad-spectrum microbicidal activity against bacteria, fungi, and viruses. (wikipedia.org)
The present study aimed to investigate the ability of the bovine cathelicidins indolicidin, bactenecin (Bac)1, Bac5, bovine myeloid antimicrobial peptide (BMAP)-27, BMAP-28, and BMAP-34 to inhibit the growth of bacteria and to enhance the sensing of nucleic acid by the host's immune system. (frontiersin.org)
Nanomolar concentrations of cathelicidins, although not bactericidal, reduced the growth rate of Gram-negative and Gram-positive bacteria. (asm.org)
Cathelicidins are thought to interact with each other within the membranes of susceptible bacteria to form assemblages that affect permeability and result in cell death ( 4 ). (asm.org)
Cathelicidin - PR1 has higher antimicrobial activity it could kill Gram-positive and Gram-negative bacteria and even some fungal species. (bvsalud.org)
Fat produces antimicrobials: Fat cells under skin produce an antimicrobial called cathelicidin that kill bacteria. (foundmyfitness.com)
The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. (nebraska.edu)
Cathelicidin LL-37 exhibits broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria, viruses, fungi and protozoa. (archivespsy.com)

In contrast to their mammalian counterparts that adopt various spatial conformations, mature avian cathelicidins are mostly α-helical. (mdpi.com)

Activation of neutrophils with phorbol myristate acetate resulted in degranulation and release of cathelicidins as well as bactericidal activity in the supernatants. (frontiersin.org)
The relationship between the bactericidal activity and several physiochemical properties of the cathelicidins was examined. (asm.org)
A mutation anticipated to destabilize interactions between cathelicidin subunits had no effect on bactericidal activity, suggesting that cathelicidins have activities beyond perforating the membrane. (asm.org)

Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. (lu.se)
Using advanced mass spectrometry technology to analyze the biochemical composition of proteins in rosacea patients, the researchers discovered an abnormality in the production of protective molecules known as cathelicidins. (rosacea-support.org)

Higher plasma levels of human cathelicidin antimicrobial protein ( hCAP18 ), which are up-regulated by vitamin D , appear to significantly reduce the risk of death from infection in dialysis patients. (wikipedia.org)
Individuals with CKD are deficient in the active form of vitamin D and thus may be deficient in human cathelicidin (hCAP18), a vitamin-D regulated protein with potentent antibacterial properties. (grantome.com)
2003). Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. (core.ac.uk)

Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. (nih.gov)

The following six groups were obtained: RA + NS, RA + low-dose cathelicidin, RA + high-dose cathelicidin, O 2 + NS, O 2 + low-dose cathelicidin, and O 2 + high-dose cathelicidin. (elsevier.com)
Sprague-Dawley rat pups were reared in either room air (RA) or hyperoxia (85% O 2 ) and were randomly treated with low-dose cathelicidin (4 mg/kg, LDC) and high-dose cathelicidin (HDC, 8 mg/kg) in 0.05 mL of normal saline (NS) administered intraperitoneally on postnatal days 1-6. (elsevier.com)

Chou, HC & Chen, CM 2019, ' Cathelicidin attenuates hyperoxia-induced kidney injury in newborn rats ', Renal Failure , vol. 41, no. 1, pp. 733-741. (elsevier.com)
Chou, HC & Chen, CM 2019, ' Cathelicidin attenuates hyperoxia-induced intestinal injury through inhibition of NF-κB activity in newborn rats ', Experimental and Molecular Pathology . (elsevier.com)

This study investigated the activity of cathelicidins against Candida albicans. (nih.gov)

Cathelicidin LL-37 modulates the proinflammatory and proangiogenic effects of UV radiation and thereby contributes to enhanced sensitivity to sun exposure in rosacea. (rosacea-support.org)

Therefore, cathelicidins appear active against C. albicans, but may be most effective as a superficial barrier to infection. (nih.gov)
We investigated the anti-inflammatory and antibacterial activities of Hc-cath, a cathelicidin peptide derived from the venom of the sea snake, Hydrophis cyanocyntus, using in vivo models of inflammation and infection. (qub.ac.uk)
This cathelicidin peptide could represent a foundational molecule to develop therapeutics for controlling MAP infection. (utmb.edu)

In summary, our proposed experiments will provide important insights into the role of cathelicidins in the pathophysiology of intestinal inflammation and IBD and the mechanisms by which cathelicidins modulate colonic inflammation. (grantome.com)
Our research proposal will examine an important and pathophysiologically relevant research topic, namely the role of cathelicidins in intestinal inflammation. (grantome.com)

We show that cathelicidin is released by neutrophils in mouse lymph nodes and that cathelicidin-deficient mice display suppressed Th17 responses during inflammation, but not at steady state. (lancs.ac.uk)
These results show that cathelicidin and KLK5 decrease in association with AZA exposure. (em-consulte.com)

Based on current spotlight innovations, we have highlighted the biochemistry, mode of action, and the importance of cathelicidins in the oral cavity. (mdpi.com)

Our finding suggests that cathelicidins positively regulate beta-cell functions and may be potentially used for intervening b-cell dysfunction-associated diseases. (diva-portal.org)

The current study demonstrates for the first time that intrarectal administration of cathelicidin may be a novel therapeutic option for IBDs. (nih.gov)
Aim 2 will examine the in vivo therapeutic effects of short- and long-term administration of cathelicidin in mouse models of acute and chronic colonic inflammation. (grantome.com)

LL-37, the only human cathelicidin, is a cationic antimicrobial peptide with antibacterial and antifungal activity. (nih.gov)

The cathelicidin LL-37 is an antimicrobial and lipopolysaccharide neutralizing peptide, possessing pro-inflammatory, tissue repair and remodeling activities. (aaem.pl)
Cathelicidin inhibits NF-κB activity and ameliorates lipopolysaccharide-induced intestinal barrier disruption in rats. (elsevier.com)

The data demonstrated that after blocking RND-type efflux pumps with 1-(1-naphthylmethyl)-piperazine, the MICs for CAP18, but not those for the other cathelicidins tested, were significantly decreased. (fu-berlin.de)

Experiments in aim 3 will determine the anti-angiogenic and anti-fibrogenic role of cathelicidin in cultured human intestinal microvascular endothelial cells and fibroblasts. (grantome.com)

1] "Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway. (tcdb.org)

Collectively, the present data support a role for certain bovine cathelicidins in helping the innate immune system to sense nucleic acids. (frontiersin.org)

The ileal expression of cathelicidin was increased by three-fold after CLP, peaking at 4 h. (springer.com)
Here we report that cathelicidin is a powerful Th17 potentiator which enhances aryl hydrocarbon receptor (AHR) and RORγt expression, in a TGF-β1-dependent manner. (lancs.ac.uk)
Despite the fact that expression of BlaI in trans on plasmid pBlaI did not fully abolish the increased beta-lactamase activity (see above), the S. aureus Newman blaI mutant expressing pBlaI showed WT levels for both CRAMP and LL-37 resistance indicating functional complementation of blaI in terms of cathelicidin susceptibility (Fig 2A and 2B). (nih.gov)
Results from our preliminary studies indicate that cathelicidins and expression of their receptors are increased in the colon of IBD patients and mouse models of colitis, but the particular cells secreting cathelicidin during intestinal inflammation are not known yet. (grantome.com)
In aim 1, we will characterize the cellular cathelicidin expression profile in colons of IBD patients and several mouse models of acute and chronic colitis and we will examine the possibility to administer sodium butyrate to increase endogenous cathelicidin levels to reduce colitis in vivo. (grantome.com)
The role of Cathelicidin in ameliorates kidney injury of the hyperoxia newborn rats was accompanied by decreased NF-κB expression, which probably through the modulating NF-κB activity in the kidney. (elsevier.com)
However, cathelicidins were not required to induce IFN-α/β expression, suggesting a redundancy of this pathway for pDC activation in injured skin. (rupress.org)
Cathelicidin treatment attenuated intestinal injury as evidenced by lower intestinal injury scores and intestinal permeability and higher intestinal barrier protein expression. (elsevier.com)
Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. (biomedcentral.com)
Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. (biomedcentral.com)
The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. (biomedcentral.com)
An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. (biomedcentral.com)

However, very little information is available to support a role of cathelicidin in intestinal inflammation. (grantome.com)
Thus exogenous cathelicidin administration may be necessary to counteract colonic inflammation. (grantome.com)
Results from our studies will provide insights of the pathophysiology of inflammatory bowel disease and evaluate the therapeutic potential of cathelicidins in intestinal inflammation. (grantome.com)

Conclusions: Cathelicidin treatment attenuated kidney injury as evidenced by lower kidney injury scores, 8-OHdG-positive cells, collagen deposition, and reversion of hyperoxia-induced M1/M2 macrophage polarization. (elsevier.com)

In the event of vitamin D deficiency, the antimicrobial peptide cathelicidin is low. (livestrong.com)
In 2007, Richard Gallo and colleagues noticed that patients with rosacea had high levels of the antimicrobial peptide cathelicidin [12] and elevated levels of stratum corneum tryptic enzymes ( SCTEs ). (wikipedia.org)
MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis. (cobolab.com)
In vitro assays showed that the presence of a functional petL and petK, and therefore the presence of PEtn on lipid A and Kdo 1 , was essential for resistance to the cationic, antimicrobial peptide cathelicidin-2. (monash.edu)

A new role for cathelicidin in ulcerative colitis in mice. (nih.gov)
To examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-( Cnlp +/+ ) and knockout ( Cnlp −/− ) mice underwent cecal-ligation and puncture (CLP) followed by the assessment of septic mortality and morbidity as well as histological, biochemical, immunological, and transcriptomic analyses in the ileal tissues. (springer.com)

We find that cathelicidin-related antimicrobial peptide (CRAMP) is constitutively expressed by rat insulinoma b-cell clone INS-1 832/13. (diva-portal.org)

Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain. (wikipedia.org)
Cathelicidins, antimicrobial polypeptides found in lysosomes. (wikipedia.org)

We propose that the neutrophil cathelicidin is required for maximal Th17 differentiation, and that this is one method by which early neutrophilia directs subsequent adaptive immune responses. (lancs.ac.uk)
The human cathelicidin LL-37 plays a big part in the innate immune system. (peptidesforresearch.com)
An altered innate immune detection and response system, modulated to a large extent by the aberrant production and processing of human cathelicidin LL-37, is thought to play a central role in disease pathogenesis. (rosacea-support.org)
Moreover, besides its antimicrobial functions, increasing evidence points out that cathelicidin LL-37 influences function of cells involved in adaptive and innate immune response and takes part in the regulation of physiological and pathological processes. (archivespsy.com)

Additionally cathelicidins may also be small-sized molecules (12-18 residues) with beta-hairpin structures, stabilized by one or two disulphide bonds. (wikipedia.org)
Cathelicidins are bipartite molecules with an N-terminal cathelin domain and an antimicrobial C-terminal domain. (semanticscholar.org)

For example Histatin 5 derivatives found in human saliva, Defensin and Cathelicidins etc. (sciencearena.in)
In this study, characterization of Defensin beta 103a, hepcidin and cathelicidin is reported for the first time in bats. (ntu.edu.sg)

Zusätzlich bieten wir Ihnen Cathelicidin Kits (39) und Cathelicidin Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
Consequently, cathelicidins have captured the interest of basic investigators in the diverse fields of cell biology, immunology, protein chemistry and microbiology. (rosacea-support.org)

Cathelicidins are essential in the protection against invading pathogens through both their direct antimicrobial activity and their immunomodulatory functions. (uva.nl)
Hardly anything is known about the immunomodulatory functions of porcine cathelicidin PMAP-36. (uu.nl)

Anatomy6

Organisms9

Diseases9

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes5

Information Science8

Health Care1

Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. (1/295)

The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. (2/295)

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. (3/295)

The human antibacterial cathelicidin, hCAP-18, is bound to lipoproteins in plasma. (4/295)

Novel cathelicidins in horse leukocytes(1). (5/295)

Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. (6/295)

SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. (7/295)

Biological activities of lipopolysaccharides of Proteus spp. and their interactions with polymyxin B and an 18-kDa cationic antimicrobial protein (CAP18)-derived peptide. (8/295)

Cathelicidins

Antimicrobial Cationic Peptides

Rosacea

Candidiasis, Cutaneous

Yersinia ruckeri

Defensins

Anti-Infective Agents

Cathepsin L

Amino Acid Sequence

Blood Proteins

Molecular Sequence Data

Anti-Bacterial Agents

Neutrophils

Instillation, Drug

Microbial Sensitivity Tests

Bacteria

Pyrazinamide

Sequence Homology, Amino Acid

Proteins

Receptors, Calcitriol

Keratinocytes

Peptides

beta-Defensins

Colitis, Ulcerative

PubMed

Periodicals as Topic

Books

Publishing

MEDLINE

Serial Publications

Sheep, Domestic

Sheep

Sheep Diseases

Sheep, Bighorn

Brucella ovis

Phenylbutyrates

Muscle Cramp

Insulin-Secreting Cells

Islets of Langerhans

Urea Cycle Disorders, Inborn

Oral Health

Chickens

Macrophages

Rhamnus

Macrophage Activation

Cinchona

Histatins

Salivary Proteins and Peptides

Myofibroblasts

Wound Healing

Immunity, Innate

Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. (1/295)

The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. (2/295)

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. (3/295)

The human antibacterial cathelicidin, hCAP-18, is bound to lipoproteins in plasma. (4/295)

Novel cathelicidins in horse leukocytes(1). (5/295)

Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. (6/295)

SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. (7/295)

Biological activities of lipopolysaccharides of Proteus spp. and their interactions with polymyxin B and an 18-kDa cationic antimicrobial protein (CAP18)-derived peptide. (8/295)

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis...

Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory...

Biomatik CorporationHuman Cathelicidin Antimicrobial Peptide (CAMP) ELISA | Fisher Scientific

Cathelicidins positively regulate pancreatic beta-cell functions

Antimicrobial peptide LL-37 on surfaces presenting carboxylate anions<...

OmpA Binding Mediates the Effect of Antimicrobial Peptide LL-37 on Acinetobacter baumannii - pdf descargar

Biomolecules | Free Full-Text | Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37 -...

tuberculosis1

LL17-32

Immune Function May Increase By Eating Red Grapes, Blueberries - Redorbit

Novel Gemini vitamin D3 analogs - Danish National Research Database-Den Danske Forskningsdatabase

Human CAMP ELISA Kit Human CAMP ELISA Kit : Plasmid,ELISA Kits,antibodies,strains, - Nova lifetech Inc

Antimicrobial peptides derived from growth factors

Pharmaceuticals | Free Full-Text | Human Antimicrobial Peptides and Proteins

KAKEN - Research Projects | Study on the interaction between periodontal bacteria and human antimicrobial peptides (KAKENHI...

Importance of endosomal cathelicidin degradation to enhance DNA-induced chicken macrophage activation

An Investigation of Dysregulated Neutrophil Activity in Alpha-1 Antitr by Sarah A. Landers

April 2019 - kickkeep icu

Research Output

Crystal structure and functional mechanism of a human antimicrobial membrane channel | PNAS