Catechol 2,3-Dioxygenase
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
Estrogens, Catechol
Catechol 1,2-Dioxygenase
Catechol O-Methyltransferase
Dioxygenases
Oxygenases
Catechol Oxidase
Hydroxybenzoates
Equilenin
Pseudomonas
Benzoates
Biodegradation, Environmental
Pseudomonas putida
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Benzoic Acid
Adipates
Hydroxyestrones
Planococcus Bacteria
Acinetobacter
Alcaligenes
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Siderophores
Quinones
Monophenol Monooxygenase
Pseudomonas mendocina
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Salicylates
Normetanephrine
Ralstonia
Hydroxylation
Xylenes
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Gram-Negative Aerobic Rods and Cocci
A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.
Substrate Specificity
Parabens
Action of 3 tyrphostin derivatives on casein kinase II from rat liver. (1/1002)
AIM: To study the action of tyrphostin on casein kinase (CK) II. METHODS: CK II was partially purified from rat livers by sequential DE52 and heparin-Sepharose chromatography. CK II activity was assayed by incubating CK II with dephosphorylated casein and [gamma-32P]ATP. RESULTS: AG34 inhibited the activity of CK II with IC50 33 (27-41) mumol.L-1. Both AG372 (121 mumol.L-1) and AG1112 (150 mumol.L-1) displayed inhibitory effects on the activity of CK II. Kinetic studies of AG34 on CK II showed that it was noncompetitive with casein and ATP. CONCLUSION: AG34, AG372, and AG1112 were potent inhibitors of CK II, and the inhibitory action of AG34 was noncompetitive with casein and ATP. (+info)Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/1002)
The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity. (+info)Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (3/1002)
We identified and characterized a methyl transfer activity of the toluate cis-dihydrodiol (4-methyl-3,5-cyclohexadiene-cis-1, 2-diol-1-carboxylic acid) dehydrogenase of the TOL plasmid pWW0 towards toluene cis-dihydrodiol (3-methyl-4,5-cyclohexadiene-cis-1, 2-diol). When the purified enzyme from the recombinant Escherichia coli containing the xylL gene was incubated with toluene cis-dihydrodiol in the presence of NAD+, the end products differed depending on the presence of adenosylcobalamin (coenzyme B12). The enzyme yielded catechol in the presence of adenosylcobalamin, while it gave 3-methylcatechol in the absence of the cofactor. Adenosylcobalamin was transformed to methylcobalamin as a result of the enzyme reaction, which indicates that the methyl group of the substrate was transferred to adenosylcobalamin. Other derivatives of the cobalamin such as aquo (hydroxy)- and cyanocobalamin did not mediate the methyl transfer reaction. The dehydrogenation and methyl transfer reactions were assumed to occur concomitantly, and the methyl transfer reaction seemed to depend on the dehydrogenation. To our knowledge, the enzyme is the first dehydrogenase that shows a methyl transfer activity as well. (+info)Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. (4/1002)
Earlier study suggested that 3,4-dihydroxytamoxifen (tam catechol), a tamoxifen metabolite, is proximate to the reactive intermediate that binds covalently to proteins and possibly to DNA (). The current study demonstrates that rat and human hepatic cytochrome P-450s (CYPs) catalyze tam catechol formation from tamoxifen (tam), 3-hydroxy-tam (Droloxifene), and 4-hydroxy-tam (4-OH-tam). Higher levels of catechol were formed from 4-OH-tam and 3-hydroxy-tam than from tam. Evidence that human hepatic CYP3A4 and 2D6 catalyze the formation of tam catechol from 4-OH-tam and supportive data that the catechol is proximate to the reactive intermediate, was obtained: 1) There was a good correlation (r = 0.82; p +info)Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats. (5/1002)
AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2. Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of 63Ni was shown by the whole-body autoradiography. RESULTS: CBMIDA s.c. 0.5-1.5 g.kg-1 markedly reduced the mortality from acute poisoning of i.p. NiCl2 500 mg.kg-1. After i.p. NiCl2 in mice, the LD50 was 82.7 mg.kg-1. Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively. The LD50 of NiCl2 was 39 mg.kg-1 in rat. If CBMIDA was injected i.m. 0.5 g.kg-1 after i.p. NiCl2, the LD50 was 332 mg.kg-1. CBMIDA 1.5 g.kg-1 i.m. after i.v. 63NiCl2, decreased the contents of 63Ni in blood and lung of mice vs control mice at 24 h. The contents of 63Ni in brain, heart, spleen, and kidney were similar to those of the control mice. The content of 63Ni in bone was more than the control. The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiography showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of 63Ni in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. There was a marked reduction of 63Ni in the lung, skin, liver, and blood after i.p. CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice and rats, and decreased 63Ni levels in lung and blood. (+info)Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. (6/1002)
Two Escherichia coli transformants with catechol 1,2-dioxygenase activity were selected from a gene library of the benzamide-assimilating bacterium Arthrobacter species strain BA-5-17, which produces four catechol 1,2-dioxygenase isozymes. A DNA fragment isolated from one transformant contained a complete open reading frame (ORF). The deduced amino acid sequence of the ORF shared high identity with hydroxyquinol 1,2-dioxygenase. An enzyme expressed by the ORF was purified to homogeneity and characterized. When hydroxyquinol was used as a substrate, the purified enzyme showed 6.8-fold activity of that for catechol. On the basis of the sequence identity and substrate specificity of the enzyme, we concluded that the ORF encoded hydroxyquinol 1,2-dioxygenase. When catechol was used as a substrate, cis,cis-muconic acid and 2-hydroxymuconic 6-semialdehyde, which were products by the intradiol and extradiol ring cleavage activities, respectively, were produced. These results showed that the hydroxyquinol 1,2-dioxygenase reported here was a novel dioxygenase that catalyzed both the intradiol and extradiol cleavage of catechol. (+info)Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (7/1002)
The inotropic/lusitropic effects of beta-adrenergic agonists on the heart are mediated largely by protein kinase A (PKA)-catalyzed phosphorylation of phospholamban, the natural protein regulator of the Ca2+ pump present in sarcoplasmic reticulum (SR) membranes. Gingerol, a plant derivative, is known to produce similar effects when tested in isolated cardiac muscle. The purpose of the present study was to compare the effects of gingerol and another plant derivative, ellagic acid, on the kinetics of the SR Ca2+ pump with those of PKA-catalyzed phospholamban phosphorylation to elucidate their mechanisms of Ca2+ pump regulation. As previously demonstrated for PKA, 50 microM gingerol or ellagic acid increased Vmax(Ca) of Ca2+ uptake and Ca2+-ATPase activity assayed at millimolar ATP concentrations in light cardiac SR vesicles. Unlike PKA, which decreases Km(Ca), neither compound had a significant effect on Km(Ca) in unphosphorylated vesicles. However, gingerol increased Km(Ca) in phosphorylated vesicles, in which Ca2+ uptake was significantly increased further at saturating Ca2+ and remained unchanged at subsaturating Ca2+. An inhibition of Ca2+ uptake by gingerol at micromolar MgATP concentrations was overcome with increasing MgATP concentrations. The stimulation of Ca2+ uptake attributable to gingerol in unphosphorylated microsomes at saturating Ca2+ was 30% to 40% when assayed at 0.05 to 2 mM MgATP and only about 12% in phosphorylated microsomes as well as in rabbit fast skeletal muscle light SR. The present results support the view that an ATP-dependent increase in Vmax(Ca) of the SR Ca2+ pump plays an important role in mediating cardiac contractile responses to gingerol and phospholamban-dependent beta-adrenergic stimulation. (+info)A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. (8/1002)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. A polymorphism in NQO1, a C609T substitution, has been identified, and individuals homozygous for this change (T/T) have no detectable NQO1. Exposed workers with a T/T genotype have an increased risk of benzene hematotoxicity. This finding suggests NQO1 is protective against benzene toxicity, which is difficult to reconcile with the lack of detectable NQO1 in human bone marrow. The human promyeloblastic cell line, KG-1a, was used to investigate the ability of the benzene metabolite hydroquinone (HQ) to induce NQO1. A concentration-dependent induction of NQO1 protein and activity was observed in KG-1a cells cultured with HQ. Multiple detoxification systems, including NQO1 and glutathione protect against benzene metabolite-induced toxicity. Indeed, exposure to a noncytotoxic concentration of HQ induced both NQO1 and soluble thiols and protected against HQ-induced apoptosis. NQO1 protein and activity increased in wild-type human bone marrow cells (C/C) exposed to HQ, whereas no NQO1 was induced by HQ in bone marrow cells with the T/T genotype. Intermediate induction of NQO1 by HQ was observed in heterozygous bone marrow cells (C/T). NQO1 also was induced by HQ in wild-type (C/C) human bone marrow CD34(+) progenitor cells. Our data suggest that failure to induce functional NQO1 may contribute to the increased risk of benzene poisoning in individuals homozygous for the NQO1 C609T substitution (T/T). (+info)
Unscramble pyrocatechol | Words unscrambled from letters pyrocatechol | Scrabble Word pyrocatechol | Words Made with the...
Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis...
Kinetics and Mechanism of Birnessite Reduction by Catechol by Christopher J. Matocha, Donald L. Sparks et al.
Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in...
BRENZKATECHINVIOLETT (pyrocatechol violet): Topics by WorldWideScience.org
Team:Lethbridge/Project - 2011.igem.org
Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical Journal
One Mystery Of How Mussels Stick To Rocks, Boats Solved
Team:Toronto/Results - 2010.igem.org
Team:Toronto/Results - 2010.igem.org
Bis(O-(N-benzyl-N-(1,1-dimethylethoxy)carbonyl-ethylamine)) Catechol | CAS: 1391054-05-9 | Bis(O-(N-benzyl-N-(1,1...
Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org
The gene cluster, coding for the chlorocatechol sp. of hereditary, biochemical, - The proteasome: structure, function, and role...
Catechol boronate formation and its electrochemical oxidation - Chemical Communications (RSC Publishing)
Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org
In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates | 10.1007/s11164...
229. Does labetolol provide sufficient alpha blockade to use in high catechol states? / Dose and use of esmolol /...
Search
Comtan (Entacapone): Side Effects, Interactions, Warning, Dosage & Uses
mhpE - 4-hydroxy-2-oxovalerate aldolase - Escherichia coli (strain K12) - mhpE gene & protein
dcyphr |
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease
TCI AMERICAS 4-Nitrocatechol,5g - 20EM61|N0273-5G - Grainger
TCI AMERICAS 4-Chlorocatechol,25g - 29LF61|C0568-25G - Grainger
Catechol, 99+%, ACROS Organics™
| Fisher Scientific
Catechol (C6H6O2) | RMI
KAKEN - Researchers | NOZAKI Mitsuhiro (00025545)
Entacapone Teva - information til sundhedsfaglige - Medicin.dk
L-DOPA biotransformation: Correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with...
Plus it
Catechol | definition of catechol by Medical dictionary
Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons...
EC 1.13.11.2
Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog
Plus it
IJMS | Free Full-Text | Relation Between the Adsorbed Quantity and the Immersion Enthalpy in Catechol Aqueous Solutions on...
New Cures » cancer curing ginger
ACPD - Biodegradation of phenol and catechol in cloud water: Comparison to chemical oxidation in the atmospheric multiphase...
IJMS | Free Full-Text | The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites
인간진피섬유아세포에서 6-Shogaol의 세포보호 및 항염증 효과
Entacapone Tablets, USP*
What Is Pharmacology - Entacapone - Medicalrealm
OSA | Quantitative Analysis of Entacapone Isomers Using Surface-Enhanced Raman
Spectroscopy and Partial Least...
DNA degradation by the mixture of copper and catechol is caused by DNA-copper-hydroperoxo complexes, probably DNA-Cu(I)OOH |...
Metabolism of [6]-Shogaol in Mice and in Cancer Cells | Drug Metabolism & Disposition
A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder...
o- catechol methyltransferase inhibitors and their use in the treatment of psychiatric disorders | Semantic Scholar
6]-Gingerol >= 98 % HPLC | 23513-14-6 | Sigma...
Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA - Fingerprint
- UC Davis
butyl carbitol sds
Catechol ring-cleavage inPseudomonas cepacia: the simultaneous induction oforthoandmetapathways | SpringerLink
Non‐Carbohydrate Glycomimetics as Inhibitors of Calcium(II)‐binding Lectins - Centre de recherches sur les macromolécules...
Catechol changes in the rat rostral ventrolateral medulla following changes in systemic CO2.
Carbolic acid-Phenol | Henriettes Herbal Homepage
Complexation of Zn(II) by catechol in hydroxylic solvents
US 8492367 B2 - Use Of 2,5-dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea -
The Lens
US 2013/0296282 A1 - Methods Of Use For 2,5-dihydroxybenzene Sulfonic Acid Compounds For The Treatment Of Cancer, Rosacea And...
Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric...
Effects of hispolon on glioblastoma cell growth. - PubMed - NCBI
KEGG Metagenome: T31030
strain RP007-rif Strain Passport - StrainInfo
Inhibition of soluble catechol- O -methyltransferase and single-dose pharmacokinetics after oral and intravenous administration...
GMD - 2OXOVALERATE, TBS 1X, METHOXIM 2
GMD - 2OXOVALERATE, TBS 2X (ENOL2)
Decarboxylation of 2,3-dihydroxybenzoate to catechol supports growth of fermenting bacteria
ETIS - Grouping of phenol hydroxylase and catechol 2,3-dioxygenase genes among phenol- and p-cresol-degrading Pseudomonas...
JoVE Search Results: Catechol 1%2C2 Dioxygenase
Reverse-phase chromatography of polar biological substances: separation of catechol compounds by high-performance liquid...
Bioactive flavonoids and catechols as Hif1 and Nrf2 protein stabilizers - implications for Parkinsons disease - Fingerprint
...
Plus it
Dynamic experimental methods using in-situ measurements of the surface intermediates applied to the fine chemistry - Infoscience
Search Results
Gingerol | GreenMedInfo | Substance | Natural Medicine | Alternative
6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion...
4-Shogaol | GreenMedInfo | Substance | Natural Medicine | Alternative
Buy Δετίο Του Ιστορικού Και Πααιογραφικού Αρχείου Θ 2000
Dakin oxidation
Catechol, for example, is synthesized from o-hydroxy and o-alkoxy phenyl aldehydes and ketones, and is used as the starting ... Dakin, H.D. (1923). "Catechol". Organic Syntheses. 3: 28. doi:10.15227/orgsyn.003.0028. Surrey, Alexander R. (1946). " ...
Arachidonate 5-lipoxygenase
other dioxygenase: Catechol dioxygenase. *Homogentisate 1,2-dioxygenase. *Cysteine dioxygenase. *4-Hydroxyphenylpyruvate ...
Vitamin
Catechol, Flavin Catechol nonessential; flavin reclassified. as Vitamin B2 Vitamin L1[58] Anthranilic acid Nonessential ...
Tadalafil
Catechol metabolite. Elimination half-life. 17.5 hours. Excretion. Feces (~61%), urine (~36%)[1]. ...
Tyrosinase
The activity of tyrosinase is similar to catechol oxidase, a related class of copper oxidase. Tyrosinases and catechol oxidases ... Tyrosinase carries out the oxidation of phenols such as tyrosine and dopamine using dioxygen (O2). In the presence of catechol ... benzoquinone is formed (see reaction below). Hydrogens removed from catechol combine with oxygen to form water. ...
1,2-dihydroxynaphthalene dioxygenase
other dioxygenase: Catechol dioxygenase. *Homogentisate 1,2-dioxygenase. *Cysteine dioxygenase. *4-Hydroxyphenylpyruvate ...
Piperonal
... can be prepared by the oxidative cleavage of isosafrole or by using a multistep sequence from catechol or 1,2- ... Synthesis from catechol requires an additional step, Williamson ether synthesis using dichloromethane. Piperonal, like all ... doi:10.1016/S0040-4039(00)88578-0. Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the ...
1,3-Benzodioxole
doi:10.2174/1389200003339270 Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the Chemical ... 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes. 1,4-Benzodioxine Methylenedioxy Safrole ...
Salicylaldehyde
Dakin, H. D. (1923). "Catechol" (PDF). Organic Syntheses. 3: 28.; Collective Volume, 1, p. 149 Burgstahler, A. W.; Worden, L. R ... Salicylaldehyde is used to make the following: Oxidation with hydrogen peroxide gives catechol (1,2-dihydroxybenzene) (Dakin ...
2-Hydroxyestrone
... (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol ... Okatani Y, Fishman J (July 1986). "Inhibition of the preovulatory prolactin surge in the rat by catechol estrogens: functional ... 2-OHE1 is the most abundant catechol estrogen in the body. 2-Hydroxyestrone is not significantly uterotrophic in bioassays, ... When incubated at very high concentrations or in combination with a catechol O-methyltransferase (COMT) inhibitor to prevent ...
Naturally occurring phenols
Catechol melanins,. Flavolans (Condensed tannins),. Polyphenolic proteins, Polyphenols Raspberry ellagitannin, Tannic acid ...
History of catecholamine research
In the case the catecholamines, however, the enzymes of degradation monoamine oxidase and catechol-O-methyl transferase, like ... In this respect, ″amino-ethanol-catechol″ - noradrenaline - mimicked sympathetic nerves more closely than adrenaline did. The ... Julius Axelrod (1962). "O-Methylation of epinephrine and other catechols". Science. 126 (3270): 400-401. doi:10.1126/science. ... noradrenaline and adrenaline were O-methylated by catechol-O-methyl transferase. To fill the gap completely, however, the role ...
Methyltransferase
Catechol-O-methyltransferase (COMT) degrades a class of molecules known as catcholamines that includes dopamine, epinephrine, ... "COMT catechol-O-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. Ragsdale, S.W. "Catalysis of ... Examples include: Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate- ...
Benzoate degradation via hydroxylation
Aerobic degradation forms catechol. Anaerobic degradation forms cyclohex-1,5-diene-1-carbonylCoA. A hybrid degradation forms ...
Siderocalin
... allowing siderocalin to bind to the iron-catechol complex. Catechols can be bound by siderocalin, in the form of free ligands, ... Mammalian siderophores, specifically catechols, can be found in the human gut and in siderophores, such as enterobactin, and ... Catechol resembling molecules can act as iron ligands in the cell and in systematic circulation, ... Rogers HJ (Mar 1973). "Iron-Binding Catechols and Virulence in Escherichia coli". Infection and Immunity. 7 (3): 445-56. doi: ...
Siderophore
... the catechol-type siderophores, agrobactin; and the mixed ligand catechol-hydroxamate-hydroxy acid siderophores biosynthesized ...
Polyphenol oxidase
... catechol oxidases). The substrate preference of tyrosinases and catechol oxidases is controlled by the amino acids around the ... A mixture of monophenol oxidase and catechol oxidase enzymes is present in nearly all plant tissues, and can also be found in ... Panis F, Kampatsikas I, Bijelic A, Rompel A (February 2020). "Conversion of walnut tyrosinase into a catechol oxidase by site ... catechol oxidase Tyrosinase "Polyphenol Oxidase". Worthington Enzyme Manual. Retrieved 13 September 2011. McLarin, Mark-Anthony ...
Methoxy group
Catechol-O-methyl transferase (COMT). Many natural products in plants, e.g. lignins, are generated via catalysis by caffeoyl- ...
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Kobayashi S, Hayaishi O (1970). "Anthranilic acid conversion to catechol (Pseudomonas)". Methods Enzymol. 17A: 505-510. doi: ... catechol + CO2 + NAD(P)+ + NH3 The 5 substrates of this enzyme are anthranilate, NADH, NADPH, H+, and O2, whereas its 5 ... "Enzymatic formation of catechol from anthranilic acid". J. Biol. Chem. 239: 2204-2211. PMID 14209949. Biology portal v t e. ... products are catechol, CO2, NAD+, NADP+, and NH3. This enzyme belongs to the family of oxidoreductases, specifically those ...
Muconate lactonizing enzyme
... catechol branch and 2) protocatechuate branch. Catechol branch consists of cis, cis- muconate lactonizing enzyme, whereas a ... 3. Enzymes of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. PMID 5330966. Ornston, L.N. (1970 ... Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. ... catechol and protocatechuate, to citric acid cycle intermediates as a part of the β-ketoadipate pathway in soil microbes. Some ...
3-O-Methyldopa
... is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for ... 3-O-methyldopa is a major metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) and is formed by catechol-O-methyltransferase ( ... This process is catalyzed by catechol O-methyltransferase methylates (COMT). The action of the enzyme makes it possible the ... Tai, C. H.; Wu, R. M. (2002). "Catechol-O-methyltransferase and Parkinson's disease". Acta medica Okayama. 56 (1): 1-6. PMID ...
Muconolactone Delta-isomerase
Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes ... Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A ... of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. PMID 5330966. ...
Hydroquinone
Lander, John J.; Svirbely, John J. Lander, W. J. (1945). "The Dipole Moments of Catechol, Resorcinol and Hydroquinone". Journal ... The conversion uses hydrogen peroxide and affords a mixture of hydroquinone and catechol (benzene-1,2-diol): ...
Rhododendrol
These phenols and catechols together form ortho-quinones (o-quinones). Presence of o-quinones can lead to cytotoxicity via the ... First, RD is catalysed by tyrosinase to produce toxic metabolites as RD-cyclic catechol. These reactive metabolites cause ... After oxidation of rhododendrol by the tyrosinase enzyme, several kinds of phenols and catechols are formed. ...
Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
I Enzymatic formation of catechol from benzene". Biochemistry. 7 (7): 2653-62. doi:10.1021/bi00847a031. PMID 4298226. Biology ... catechol + NADH + H+ Thus, the two substrates of this enzyme are cis-1,2-dihydrobenzene-1,2-diol and NAD+, whereas its 3 ... products are catechol, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH- ...
Crown ether
... s are much broader than the oligomers of ethylene oxide; an important group are derived from catechol. Crown ethers ...
Nitecapone
"Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of ... Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT). It ... Catechol-O-methyltransferase inhibitor F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978 ...
Tanning (leather)
... see catechol), and myrobalans from Terminalia spp., such as Terminalia chebula. In Ethiopia, the combined vegetable oils of ...
Benzene 1,2-dioxygenase
I Enzymatic formation of catechol from benzene". Biochemistry. 7 (7): 2653-62. doi:10.1021/bi00847a031. PMID 4298226. Biology ...
Deoxyepinephrine
M. L. Tainter (1930). "Comparative actions of sympathomimetic compounds: catechol derivatives." J. Pharmacol. Exp. Ther. 40 43- ... "methylamino-ethyl-catechol", as they called it, had about 1/7 x the pressor potency of epinephrine, but about 5 x the potency ... "methylamino-ethyl-catechol", under the name "epinine", as a substitute for epinephrine. Tainter further quantified the pressor ... of dopamine ("amino-ethyl-catechol") in cat preparations. The Buroughs Wellcome Co., for which Barger, Dale and Pyman (see " ...
ICSC 0411 - CATECHOL
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations ...
catechol (CHEBI:18135)
... has role plant metabolite (CHEBI:76924) catechol (CHEBI:18135) is a catechols (CHEBI:33566) catechol ( ... catechol (CHEBI:18135) has role allelochemical (CHEBI:62215) catechol (CHEBI:18135) has role genotoxin (CHEBI:50902) ... catechol β-D-glucuronide (CHEBI:133689) has functional parent catechol (CHEBI:18135). guaiacol (CHEBI:28591) has functional ... aspalathin (CHEBI:79078) is a catechol (CHEBI:18135). caffeyl alcohol (CHEBI:86071) is a catechol (CHEBI:18135). droxidopa ( ...
CDC - NIOSH Pocket Guide to Chemical Hazards -
Catechol
NIOSH Skin Notation Profiles: Catechol (2019-118) | NIOSH | CDC
A literature search was conducted through February 2018 to identify catechol toxicokinetics, acute toxicity, repeated-dose ... of the potential health effects of dermal exposure to catechol and the potential for direct skin injuries from catechol. ... assignment for catechol. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence ... or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to catechol. The criteria for the ...
Catechol, TBDMS derivative
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Catechol - Wikipedia
... catechol was listed as pyrocatechol. In 1879, the Journal of the Chemical Society recommended that catechol be called "catechol ... Catechol occurs as feathery white crystals that are very rapidly soluble in water. Catechol was first isolated in 1839 by Edgar ... Catechols produce quinones with the addition of ceric ammonium nitrate (CAN). Catechol is the conjugate acid of a chelating ... Catechol moieties are also found widely within the natural world. Arthropod cuticle consists of chitin linked by a catechol ...
Autoxidation of catechol(amine)s | SpringerLink
The reaction rate constants of the distinct charged particles, in which catechol(amine)s can appear, are... ... The autoxidation of nine catecholamines and two catechols as a function of pH was studied. ... The purification and properties of pig-liver catechol-O-methyltransferase. Eur J Biochem 1978;88:439-44.PubMedGoogle Scholar ... Flohe L, Schwabe K-P. Kinetics of purified catechol-O-methyltransferase. Biochim Biophys Acta 1970;220:469-76.PubMedGoogle ...
Catechol- | Carolina Population Center
2006). Catechol-. Breast Cancer Research and Treatment, 99(2), 235-240.. Abstract. The gene encoding catechol-O- ... Catechol-. Citation. Gaudet, Mia M.; Bensen, Jeannette T.; Schroeder, Jane C.; Olshan, Andrew F.; Terry, Mary Beth; Eng, Sybil ... methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide ...
Catechol estrogen - Wikipedia
A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in ... Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and ...
Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. - PubMed - NCBI
Patterns of plasma levels of catechols in neurogenic orthostatic hypotension.. Goldstein DS1, Polinsky RJ, Garty M, Robertson D ... Plasma levels of catechols were normal in most patients with multiple system atrophy, consistent with relatively intact ... The results demonstrate the value of examining patterns of plasma levels of catechols to elucidate mechanisms of neurogenic ... most patients with pure autonomic failure had decreased levels of all four catechols, consistent with degenerative loss of ...
Catechols | GreenMedInfo | Substance | Natural Medicine | Alternative
This topic has 11 study abstracts on Catechols indicating that they may have therapeutic value in the treatment of Brain ... Substances : 5-hydroxytryptamides, Caffeine, Catechols, Chlorogenic Acid, Coffee, N-methylpyridinium, Pyrogallol, Trigonelline ... Catechols have anti-inflammatory effects in lipopolysaccharide-stimulated microglia cells, inhibiting neurotoxicity. Jun 24, ... Substances : Acacia catechu, Catechols. Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide- ...
Claisen Rearrangement In Catechols - Synthesis of 4-Allylcatechol - [www.rhodium.ws]
Catechol monoallyl ether To stirred catechol (44 g.; 0.4 mole), dry acetone (125 ml.) and freshly fused potassium carbonate ( ... In all cases both mono- and diallyl ethers of catechol were formed. The catechol monoallyl ether on rearrangement gave 3- and 4 ... Hence, it was decided to condense acrylic acid with catechol using polyphosphoric acid to get acryloyl catechol and then ... From the residue consisting of unreacted catechol, potassium carbonate and potassium bromide, catechol (9.9 g.) was recovered ...
Estrogens, catechol - definition of Estrogens, catechol by The Free Dictionary
Estrogens, catechol synonyms, Estrogens, catechol pronunciation, Estrogens, catechol translation, English dictionary definition ... of Estrogens, catechol. also oes·tro·gen n. 1. Any of several steroid hormones, such as estradiol and estrone, that are ... redirected from Estrogens, catechol). Also found in: Thesaurus, Medical, Encyclopedia. es·tro·gen. also oes·tro·gen (ĕs′trə-jən ... Estrogens, catechol - definition of Estrogens, catechol by The Free Dictionary https://www.thefreedictionary.com/Estrogens%2c+ ...
catechol catabolism
... (meta ring cleavage). When cursor points to a box further details will be displayed in a tooltip window. If ... catechol biosynthesis. EC 1.2.1.10 acetaldehyde dehydrogenase (acetylating). EC 1.2.1.85 2-hydroxymuconate-6-semialdehyde ... EC 1.13.11.2 catechol 2,3-dioxygenase. EC 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase. EC 4.1.1.77 4-oxalocrotonate ...
Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. - PubMed - NCBI
Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators | PNAS
catechol estrogen(s);. CE-Q,. catechol estrogen quinone(s);. DMF,. dimethylformamide;. DMSO,. dimethyl sulfoxide;. E1,. estrone ... Covalent Binding of 4-Hydroxy Catechol Estrogens and Their Quinones to DNA.. E1-3,4-Q or E2-3,4-Q (1 mg/50 μl of DMSO) was ... Furthermore, the hexestrol catechol is activated by HRP, LP, or cytochrome P450 to form an N7Gua adduct (ref. 28 and S. T. Jan ... Carcinogenicity of Catechol Estrogens and Their Quinones in B6C3F1 Mice.. Litters of B6C3F1 mice were obtained from cross- ...
Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators | PNAS
catechol estrogen(s);. CE-Q,. catechol estrogen quinone(s);. DMF,. dimethylformamide;. DMSO,. dimethyl sulfoxide;. E1,. estrone ... Catechol-O-Methyltransferase (COMT)-mediated Metabolism of Catechol Estrogens: Comparison of Wild-Type and Variant COMT ... Covalent Binding of 4-Hydroxy Catechol Estrogens and Their Quinones to DNA.. E1-3,4-Q or E2-3,4-Q (1 mg/50 μl of DMSO) was ... Furthermore, the hexestrol catechol is activated by HRP, LP, or cytochrome P450 to form an N7Gua adduct (ref. 28 and S. T. Jan ...
RCSB PDB
- 1JR4: CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX Literature Report Page
O-Methylation of Epinephrine and Other Catechols in vitro and in vivo | Science
497f) Explaining Catechol-Cation Binding Synergy with Bond Energies and Lifetimes | AIChE Academy
An understanding of catechol-cation binding synergy should aid the design of biologically inspired adhesives for medical, ... To further study catechol-cation binding synergy, small molecules were synthesized with systematically varying intramolecular ... Previous work has shown that molecules containing both catechols and cations adhere to inorganic surfaces with higher adhesion ... we propose a new explanation for binding synergy between catechols and cations based on the relationship between solution ...
Catechol, 99+%, ACROS Organics™
| Fisher Scientific
Catechol boronate formation and its electrochemical oxidation - Chemical Communications (RSC Publishing)
phenol to catechol conversion
It has been found that when the process of conversion of phenol to a mixture of hydroquinone and catechol is carried out in ... This invention relates to an improved process for the conversion of phenol to a mixture of hydroquinone and catechol. In ... an object of this invention to provide an improved process for the oxidation of phenol to hydroquinone and catechol wherein the ... production of the undesired by product tar is suppressed leading thereby to enhanced yields of hydroquinone and catechol. not ...
Vibrational energy redistribution in catechol during ultraviolet photolysis - Physical Chemistry Chemical Physics (RSC...
This article reports the striking interplay between the molecular structure and the photodissociation dynamics of catechol (a ... catechol. , D0(H-catechoxyl) ≤ 27 480 ± 50 cm−1, ∼2500 cm−1 lower than that of the sole O-H bond in bare phenol. . As a ... catechol. during ultraviolet photolysis G. A. King, T. A. A. Oliver, R. N. Dixon and M. N. R. Ashfold, Phys. Chem. Chem. Phys. ... catechol. is reduced relative to that in phenol. , yielding a particularly broad distribution of product vibrations for λphot ...
Catechol inhibits FADH2-linked respiration in rat liver mitochondrial fraction | UL - University of Limerick
Electrochemical Investigation of Catechol at Poly(niacinamide) Modified Carbon Paste Electrode: A Voltammetric Study
... was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. Compared to bare ... MCPE shows good electrocatalytic activity towards the oxidation of catechol in phosphate buffer solution (PBS) of physiological ... By increasing the concentration of catechol, goes on increasing with shifting towards positive side. The graph of versus ... L. A. Alshahrani, X. Li, H. Luo et al., "The simultaneous electrochemical detection of catechol and hydroquinone with [Cu(Sal-β ...
Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors, Volume 95 - 1st Edition
Purchase Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors, Volume 95 - 1st Edition ... Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors, Volume 95 1st Edition. 0.0 star ... Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinsons ... Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors ...
Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion
The biological activity of a series of natural catechol estrogens was examined under conditions of continuous administration. 2 ... Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion Endocrinology. 1979 ... The biological activity of a series of natural catechol estrogens was examined under conditions of continuous administration. 2 ...
Plus it
Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk. Katja Mitrunen, Nadejda Jourenkova, Vesa Kataja, Matti ... Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk. Katja Mitrunen, Nadejda Jourenkova, Vesa Kataja, Matti ... Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk. Katja Mitrunen, Nadejda Jourenkova, Vesa Kataja, Matti ... Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk Message Subject (Your Name) has forwarded a page to you ...
Inhibitors of Catechol-O-Methyltransferase | BenthamScience
Inhibitors of Catechol-O-Methyltransferase. Author(s): James C. Barrow. Lieber Institute for Brain Development, 336 John G. ... Keywords:Catechol-O-methyltransferase, COMT, dopamine, L-DOPA, Parkinsons disease, nitrocatechol, MB-COMT, SAM Binding, HPLC, ... Keywords: Catechol-O-methyltransferase, COMT, dopamine, L-DOPA, Parkinsons disease, nitrocatechol, MB-COMT, SAM Binding, HPLC ... Since the identification of Catechol-O-Methyltransferase (COMT) by Axelrod in 1957, many inhibitors of this enzyme have been ...
COMTEstrogensPolymorphismEnzymeVal158MetDopamineCatecholaminesMetabolitesMoietyHydroquinoneMetabolismGuaiacolBiosynthesisResorcinolDerivativesQuinonesSubstratesInhibitorPhenol and catecholCleavageElectrochemicalMembrane-boundAqueousDioxygenaseInhibitionBenzeneDifferent catecholCatecholamineMethyltransferaseBlock copolymerSubstrate specificityEnzymesProteinConjugate acidSynthesisMethylReactionKineticsHydrolysisDegradationMoleculeOxidation of phenolEstrogen formationReversibleOxidativeAromaticMoietiesCopolymersSensitivity
COMT51
- The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in extrahepatic tissues, and are metabolized by catechol O-methyltransferase (COMT) into methoxylated estrogens such as 2-methoxyestradiol and 4-methoxyestrone as well as by conjugation via other phase II enzymes. (wikipedia.org)
- In addition to being substrates for COMT similarly to catecholamines like dopamine, norepinephrine, and epinephrine, catechol estrogens are potent competitive inhibitors of COMT as well as of tyrosine hydroxylase, and may affect both catecholamine biosynthesis and metabolism. (wikipedia.org)
- The gene encoding catechol-O-methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide polymorphisms (SNPs) that influence enzyme activity. (unc.edu)
- Using catechol O-methyltransferase (COMT) as a model, we perform discrete molecular dynamics and computational docking simulations to elucidate the initial stages of cofactor binding. (nih.gov)
- We examined 483 Finnish breast cancer cases and 482 population controls to determine the potential effect of catechol- O -methyltransferase ( COMT ) genotype in individual susceptibility to breast cancer. (aacrjournals.org)
- They are mainly inactivated by COMT, 3 a Phase II enzyme that methylates catechol estrogens to less polar monomethyl ethers, which can then be excreted. (aacrjournals.org)
- Since the identification of Catechol-O-Methyltransferase (COMT) by Axelrod in 1957, many inhibitors of this enzyme have been reported. (eurekaselect.com)
- This review summarizes the major classes of COMT inhibitors, from early catechol and pyrogallol variants to bisubstrate inhibitors. (eurekaselect.com)
- This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene. (dovepress.com)
- A case-control study was performed to assess the potential influence of catechol O-methyl transferase (COMT) genotype on the risk of breast cancer in Korean women. (nih.gov)
- 2005). Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. (salimetrics.com)
- 2004). Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain. (salimetrics.com)
- Rs165656, a new SNP found to be associated with disc degeneration, was in catechol-O-methyltransferase ( COMT ), a gene with well-recognized pain involvement, especially in female subjects (p=0.01). (medsci.org)
- COMT (catechol-O-methyltransferase) is an enzyme which inactivates catechols, including the significant neurotransmitters dopamine, noradrenaline and adrenaline [ 9 ]. (medsci.org)
- A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. (lu.se)
- misc{d359f84f-dce1-45b6-b22f-f3eac7b75b3d, abstract = {A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. (lu.se)
- Catechol- O -methyltransferase (COMT) metabolizes catecholamines ( Männisto and Kaakkola, 1999 ). (jneurosci.org)
- Catechol-O-methyltransferase (COMT) plays an essential role in detoxification of catechols by transferring the methyl group from S-adenosyl-L-methionine to the substrate. (muni.cz)
- Catechol- O -methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. (sciencemag.org)
- Of particular interest was catechol-O-methyl transferase (COMT), an enzyme involved in metabolizing catecholamines released following neuronal activity. (pubmedcentralcanada.ca)
- After validating altered expression of representative candidates by western blot analysis, we subsequently targeted catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of the catecholamines dopamine and norepinephrine, for a more extensive characterization. (pubmedcentralcanada.ca)
- Despite the addition of a peripheral decarboxylase inhibitor, levodopa is extensively metabolised in the periphery to 3-O-methyldopa (3-OMD) by catechol-O-methyltransferase (COMT). (bmj.com)
- Objectives The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. (bmj.com)
- The effect of a non-synonymous single nucleotide polymorphism (SNP), rs4680 (V158M), in the gene coding for the enzyme catechol-O-methyltransferase (COMT) has been widely investigated in genetic association studies of chronic widespread pain (CWP). (bmj.com)
- COMT degrades catecholamines, such as dopamine and epinephrine and catechol-containing drugs. (bmj.com)
- Catechol- O -methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic catechols and catecholamines. (aspetjournals.org)
- Genetic variants of catechol-O-methyltransferase (COMT) gene have previously been shown to be associated with pain sensitivity and pain medication. (uio.no)
- Conjugation of a structurally diverse set of 53 catechol compounds was studied in vitro using six recombinant human sulfotransferases (SULTs), five UDP-glucuronosyltransferases (UGT) and the soluble form of catechol O -methyltransferase (S-COMT) as catalyst. (aspetjournals.org)
- Most of the catechols studied were substrates of S-COMT and four SULT isoforms (1A1, 1A2, 1A3, and 1B1), but the rates of conjugation varied considerably, depending on the substrate structure and the enzyme form. (aspetjournals.org)
- Many clinical and genomic association studies suggested that the catechol-Omethyltransferase (COMT) gene region was an important genetic locus for psychiatric disorders, because of the proposed relationship between its function in catecholaminergic neurotransmission and individual response to antidepressants, and vulnerability to psychiatric disorders. (eurekaselect.com)
- Neslihan Aygun Kocabas, "Catechol-O-Methyltransferase (COMT) Pharmacogenetics in the Treatment Response Phenotypes of Major Depressive Disorder (MDD)", CNS & Neurological Disorders - Drug Targets (2012) 11: 264. (eurekaselect.com)
- Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants' mindsets about stress. (columbia.edu)
- Background: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. (ebscohost.com)
- Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy. (ebscohost.com)
- Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be associated with treatment response in depression. (ebscohost.com)
- The inhibition of soluble catechol- O -methyltransferase (S-COMT) in red blood cells (RBCs) by entacapone, and the pharmacokinetics of entacapone after single oral (5-800 mg) and IV (25 mg) doses have been examined in an open study in 12 healthy young male volunteers. (springer.com)
- The present invention relates to 4-pyridinone compound as catechol -O- methyltransferase (COMT) inhibitors and are useful in the treatment or prevention of COMT enzyme is involved in neurological and psychiatric disorders and diseases. (semanticscholar.org)
- Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. (helsinki.fi)
- COMT is involved in the O-methylation of L-DOPA, dopamine and other catechols. (helsinki.fi)
- COMT (Catechol-O-methyltransferase) inhibitors enhances levodopa treatment as they inhibit levodopa's peripheral metabolism, thereby enhancing its bioavailability. (holisticonline.com)
- Aims To study the possible association of catechol-O-methyltransferase ( COMT) Val158Met polymorphism with multiple and solitary uterine leiomyomas (ULs) and to check whether the COMT Val/Val genotype is associated with MED12 exon 2 mutations in fibroids. (bmj.com)
- The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. (lancs.ac.uk)
- MBS005657 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Catechol-O-Metthyhransferase (COMT) ELISA Kit target analytes in biological samples. (mybiosource.com)
- In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. (mybiosource.com)
- Catechol-O-Methyltransferase (COMT) is an enzyme that inactivates catecholamines, such as epinephrine, norepinephrine and dopamine. (genelex.com)
- Recent work focusing on the relationship between brain structure and the catechol-O-methyltransferase (COMT) gene polymorphism suggests that functional COMT variants may affect brain volume in healthy individuals and in schizophrenia patients. (nispa.nl)
- Catechol-o-methyltransferase (COMT) alters extracellular dopamine levels in PFC, and its gene contains a functional polymorphism (Val(158)Met) that has been associated with variation in PFC function. (ox.ac.uk)
- Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. (ox.ac.uk)
- We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-o-methyltransferase (COMT) Val108/158Met functional polymorphism. (ox.ac.uk)
- Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain. (ox.ac.uk)
- Catechol-o-methyltransferase (COMT) is important for modulating dopamine levels, prefrontal cortex (PFC) function, and several psychiatric phenotypes. (ox.ac.uk)
Estrogens16
- The catechol estrogens are endogenous metabolites of estradiol and estrone and include the following compounds: 2-Hydroxylated: 2-Hydroxyestradiol 2-Hydroxyestrone 2-Hydroxyestriol 4-Hydroxylated: 4-Hydroxyestradiol 4-Hydroxyestrone 4-Hydroxyestriol The most abundant catechol estrogen in serum and urine is 2-hydroxyestrone, with 2-hydroxyestradiol and 2-hydroxyestriol also being formed, while the principal 4-hydroxy catechol estrogen, 4-hydroxyestrone, is present in only small amounts in urine. (wikipedia.org)
- Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and semiquinones, and this has been hypothesized to contribute to estrogen-induced carcinogenesis. (wikipedia.org)
- Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. (wikipedia.org)
- 2-Hydroxylated catechol estrogens are weak and possibly antiestrogenic estrogens, whereas their 4-hydroxylated counterparts are more potent in their estrogenic activity. (wikipedia.org)
- For instance, 2-hydroxyestrone reportedly shows negligible uterotrophic effect in animals, whereas 4-hydroxy catechol estrogens show moderate changes in stimulating uterine weight. (wikipedia.org)
- This relationship led us to postulate that oxidation of the carcinogenic 4-hydroxy catechol estrogens (CE) of estrone (E 1 ) and estradiol (E 2 ) to catechol estrogen-3,4-quinones (CE-3, 4-Q) results in electrophilic intermediates that covalently bind to DNA to form depurinating adducts. (pnas.org)
- This relationship led us to postulate that oxidation of catechol estrogens (CE) to CE quinones (CE-Q) results in electrophilic intermediates that also covalently bind to DNA and form depurinating adducts. (pnas.org)
- The biological activity of a series of natural catechol estrogens was examined under conditions of continuous administration. (nih.gov)
- In contrast to free-formed catechol estrogens, the [C. (thefreedictionary.com)
- differences between phenol and Catechol estrogens. (thefreedictionary.com)
- Catechol (hydroxylated) estrogens have carcinogenic potential, thought to arise from reactive catechol intermediates with enhanced capability of forming mutation-inducing DNA adducts. (aacrjournals.org)
- One mechanism by which in utero exposure to estrogens may influence the development of TGCC is via the effects of catechol metabolites of 17β-estradiol (E2) and estrone: 4-OH E2, 4-OH estrone, 2-OH E2, and 2-OH estrone. (aacrjournals.org)
- Catechol estrogens, which are produced by cytochrome P 450 (CYP)-catalyzed hydroxylation of estrogens, readily undergo redox cycling between semiquinone and quinone forms through which reactive oxygen species (ROS) are produced. (aacrjournals.org)
- Mammalian adult male germ cells and supporting gonadal tissues are highly susceptible to the toxic effects of ROS ( 9 - 12 ), and catechol estrogens seem to be involved in some of these toxic effects ( 13 , 14 ). (aacrjournals.org)
- Catechol estrogens and/or oxidative damage resulting from maternal sources could also contribute to testicular carcinogenesis in utero . (aacrjournals.org)
- Variation in maternal or offspring genes encoding estrogen-metabolizing enzymes could influence the level of exposure to prenatal catechol estrogens and could therefore serve as biomarkers in a retrospective study of hormonal risk factors for TGCC. (aacrjournals.org)
Polymorphism11
- 1996). Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. (salimetrics.com)
- Catechol-O-methyltransferase, which has a functional genetic polymorphism, plays an important role in dopamine metabolism. (ovid.com)
- The study analyzed the association between the catechol-O-methyltransferase gene polymorphism and alcohol dependence in the Korean population. (ovid.com)
- Polymerase chain reaction-based genotyping was used to verify the presence of the catechol-O-methyltransferase gene polymorphism. (ovid.com)
- This suggests that the catechol-O-methyltransferase gene polymorphism is not associated with the development of alcohol dependence, but may affect the susceptibility to a clinical heterogeneity of alcohol dependence, at least in the Korean population. (ovid.com)
- Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence. (nel.edu)
- The main aim of the study was to ascertain whether the Val158Met catechol-O-methyltransferase gene polymorphism is associated with methamphetamine dependence in this Central European country. (nel.edu)
- More attention should also be paid to possible role of the Val158Met catechol-O-methyl-transferase gene polymorphism in individual clinical subtypes of dependence on methamphetamine involving e.g. psychotic features or violence. (nel.edu)
- Hosák A, Serý M, Beranek A, Alda A, Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence. (nel.edu)
- No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population. (ebscohost.com)
- Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users. (nispa.nl)
Enzyme7
- Small amounts of catechol occur naturally in fruits and vegetables, along with the enzyme polyphenol oxidase (also known as catecholase, or catechol oxidase). (wikipedia.org)
- Upon mixing the enzyme with the substrate and exposure to oxygen (as when a potato or apple is cut and left out), the colorless catechol oxidizes to reddish-brown melanoid pigments, derivatives of benzoquinone. (wikipedia.org)
- Under the assay conditions used, E-4-H was the predominant catechol estrogen-forming monooxygenase enzyme. (biomedsearch.com)
- Dependence on methamphetamine is markedly related to the brain neurotransmitter dopamine, metabolised by catechol-O-methyltransferase enzyme. (nel.edu)
- The structural and spectroscopic characterization of mononuclear iron(III)-catecholato complexes of ligand L4 (methyl bis(1-methylimidazol-2-yl)(2-hydroxyphenyl)methyl ether, HL4) are described, which closely mimic the enzyme-substrate complex of the intradiol-cleaving catechol dioxygenases. (uu.nl)
- Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. (ox.ac.uk)
- Ito, M & Que, L 1997, ' Biomimetic Extradiol Cleavage of Catechols: Insights into the Enzyme Mechanism ', Angewandte Chemie (International Edition in English) , vol. 36, no. 12, pp. 1342-1344. (umn.edu)
Val158Met2
- Structural equation modeling was applied to data on 704 Norwegian children to test whether the catechol-O-methyltransferase Val158Met genotype moderates the effect of disorganized attachment, which was measured dimensionally at 4 years of age using the Manchester Child Attachment Story Task, on changes in aggressive behavior and social competence from ages 4 to 6. (samforsk.no)
- The influence of Catechol-O-Methyltransferase Val158Met on fear of pain and placebo analgesia. (painresearchforum.org)
Dopamine2
- Kaakkola S, Wurtman R (1993) Effects of catechol-O-methyltransferase inhibitors and 1-3, 4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. (springer.com)
- Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. (mybiosource.com)
Catecholamines5
- The autoxidation of nine catecholamines and two catechols as a function of pH was studied. (springer.com)
- Enzymatic O -methylation of catechols and catecholamines. (springer.com)
- Ionization constants of catechols and catecholamines. (springer.com)
- 2. Term loosely used for catechin, which contains an o -catechol moiety, and as the root of catecholamines, which are pyrocatechol derivatives. (thefreedictionary.com)
- The catechol set comprised endogenous compounds, such as catecholamines and catecholestrogens, drugs, natural plant constituents, and other catechols with diverse substituent properties and substitution patterns. (aspetjournals.org)
Metabolites5
- A significant relationship of equilibrium can be identified between the 2 and 16 hydroxy catechol metabolites. (thefreedictionary.com)
- Diethylstilbestrol, a known transplacental testicular carcinogen in animals, seems to exert its effects in part through its catechol and/or reactive quinone metabolites ( 15 ). (aacrjournals.org)
- Several structural factors governing the conjugation of catechol hormones, metabolites, and drugs were identified. (aspetjournals.org)
- Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. (aspetjournals.org)
- Metabolites of entacapone [(E)-2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide++ +], a potent inhibitor of catechol-O-methyltransferase, were isolated from human and rat urine. (aspetjournals.org)
Moiety7
- Arthropod cuticle consists of chitin linked by a catechol moiety to protein. (wikipedia.org)
- Analysis of the product vibrational energy distribution also reveals that the O-H bond strength of the non hydrogen bonded O-H moiety in catechol , D 0 (H-catechoxyl) ≤ 27 480 ± 50 cm −1 , ∼2500 cm −1 lower than that of the sole O-H bond in bare phenol . (rsc.org)
- Then, the modified MMT was coated onto a surface using the reaming catechol moiety [15, 16]. (thefreedictionary.com)
- The synthesis, spectroscopic and electrochemical characterisation of ruthenium (II) polypyridyl mononuclear and dinuclear complexes o f a 5-(2-pyridyl)-l,2,4-triazole ligand containing a catechol moiety are described. (dcu.ie)
- The protected catechol moiety results in coordination of the Ru(Lx)2 (where Lx is bpy, dgbpy, phen, d8-phen or dcbpy) via N1 of the triazole and N1 of the pyridyl ring, which is confirmed by X-Ray crystallography. (dcu.ie)
- Part 1: The importance of the catechol moiety and aspects of the B-ring structure. (lu.se)
- This part concerns the catechol moiety of the A-ring as well as the 2,3,4,5-tetrahydro-1H-2-azepine moiety (the B-ring) of capsazepine. (lu.se)
Hydroquinone6
- It is, therefore, an object of this invention to provide an improved process for the oxidation of phenol to hydroquinone and catechol wherein the production of the undesired by product tar is suppressed leading thereby to enhanced yields of hydroquinone and catechol. (americans-world.org)
- It has been found that when the process of conversion of phenol to a mixture of hydroquinone and catechol is carried out in accordance with the above mentioned features and embodiments of this invention, there is a significant reduction in the amount of by-product tar formation. (americans-world.org)
- This invention relates to an improved process for the conversion of phenol to a mixture of hydroquinone and catechol. (americans-world.org)
- Simultaneous Detection of Hydroquinone and Catechol Using Platinum Nanoparticles Decorated Graphene/Poly-Cyclodextrin/Multiwalled Carbon Nanotubes (MWCNTs) Nanocomposite Based Biosensor. (americanelements.com)
- The simultaneous determination of hydroquinone (HQ) and catechol (CC) at PtNPs/Gr-CDP-MWCNTs/GCE is reported in the present work. (americanelements.com)
- Due to the excellent catalytic activity, enhanced electrical conductivity, high surface area and porous structure of the RGO-MWNTs, the RGO-MWNTs/GCE achieved the simultaneous measurement of hydroquinone (HQ), catechol (CC), p-cresol (PC) and nitrite (NO 2 − ) with well-separate four peaks. (deepdyve.com)
Metabolism4
- Catechols such as DHSA are produced through the metabolism of cholesterol by bacteria such as Mycobacterium tuberculosis. (wikipedia.org)
- The level of catechol metabolism in the RVLM 1) is continuously related to the level of arterial CO2, 2) functions close to its resting level under baseline nonstimulated condition with respect to CO2, and 3) is reversibly modified on changes in capnia. (biomedsearch.com)
- strain P51 tcb gene cluster, which encodes metabolism of chlorinated catechols: evidence for specialization of catechol 1,2-dioxygenases for chlorinated substrates. (asm.org)
- Keränen T, Gordin A, Harjola V-P, Karlsson M, Korpela K, Pentikäinen PJ, Rita H, Seppälä L, Wikberg T (1993) The effect of catechol-O-methyltransferase inhibition by entacapone, on the pharmacokinetics and metabolism of levodopa in healthy volunteers. (springer.com)
Guaiacol1
- Its methyl ether derivative, guaiacol, converts to catechol via hydrolysis of the CH3-O bond as promoted by hydriodic acid. (wikipedia.org)
Biosynthesis3
- Two regions involved in catechol biosynthesis (cbs) of Erwinia carotovora W3C105 were cloned by functional complementation of Escherichia coli mutants that were deficient in the biosynthesis of the catechol siderophore enterobactin (ent). (elsevier.com)
- Although functions encoded by catechol biosynthesis genes (cbsA, cbsB, cbsC, cbsD, and cbsE) of E. carotovora were interchangeable with those encoded by corresponding enterobactin biosynthesis genes (entA, entB, entC, entD, and entE), only cbsE hybridized to its functional counterpart (entE) in E. coli. (elsevier.com)
- Strains of E. carotovora fell into nine groups on the basis of sizes of restriction fragments that hybridized to the cbsEA region, indicating that catechol biosynthesis genes were highly polymorphic among strains of E. carotovora. (elsevier.com)
Resorcinol1
- Commonly, the molecular structure of flavonoids of high biological activity like quercetin or naringenin [4] includes a group derived from resorcinol and/or catechol [5,6]. (scielo.org.ar)
Derivatives4
- Like other difunctional benzene derivatives, catechol readily condenses to form heterocyclic compounds. (wikipedia.org)
- Moreover, amongst a number of catechol derivatives tested 2 4-allylcatechol exhibited the maximum antioxidant activity. (erowid.org)
- Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes. (thefreedictionary.com)
- Borgulya J, Bruderer H, Bernauer K, Zürcher G, Da Prada M (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives - synthesis and structure activity studies. (springer.com)
Quinones1
- CO. Catechols produce quinones with the addition of ceric ammonium nitrate (CAN). (wikipedia.org)
Substrates2
- Copper(II)-induced oxidations of aromatic substrates: catalytic conversion of catechols to o-benzoquinones. (americans-world.org)
- Specifically, membrane-bound catechol- O -methyltransferase (MBCOMT) is an integral membrane protein that catalyzes the methylation of catechol substrates and has been linked to several diseases such as Parkinson's disease and Schizophrenia. (biomedcentral.com)
Inhibitor1
- Karlsson M, Wikberg T (1992) Liquid chromatographic determination of a new catechol-O-methyltransferase inhibitor, entacapone, and its Z-isomer in human plasma and urine. (springer.com)
Phenol and catechol2
- In the current study, we measured the biodegradation rates of phenol and catechol, which are known pollutants, by one of the most active strains selected during our previous screening in clouds ( Rhodococcus enclensis ). (atmos-chem-phys-discuss.net)
- The experimentally derived biodegradation rates are included in a multiphase box model to compare the chemical loss rates of phenol and catechol in both the gas and aqueous phases to their biodegradation rate in the aqueous phase under atmospheric conditions. (atmos-chem-phys-discuss.net)
Cleavage2
- Iron-containing dioxygenase enzymes catalyze the cleavage of catechol. (wikipedia.org)
- Ibuprofen-induced washed-cell suspensions also metabolized phenylacetic acid and 2-phenylpropionic acid to catechol, while 3- and 4-tolylacetic acids and 2-(4-tolyl)-propionic acid were metabolized to the corresponding methyl catechols before ring cleavage. (asm.org)
Electrochemical1
- A polymeric thin film modified electrode, that is, poly(niacinamide) modified carbon paste electrode (MCPE), was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. (hindawi.com)
Membrane-bound1
- Generation of membrane-bound catechol-O-methyl transferase deficient mice with disctinct sex dependent behavioral phenotype. (helsinki.fi)
Aqueous3
- During daytime, biodegradation of catechol is even predicted to exceed the chemical activity in the aqueous phase and to represent a significant sink (17 %) of total catechol in the atmospheric multiphase system. (atmos-chem-phys-discuss.net)
- 3-(2-Hydroxyphenoxy)phthalide is an intermediate in the hydrolysis of OO-(2-carboxybenzylidene) catechol in aqueous buffers of pH 2·9-5. (hud.ac.uk)
- Poocharoen, Boonthong, "Reaction of aqueous catechol solutions with minerals" (1972). (pdx.edu)
Dioxygenase9
- Cloning and expression of Acinetobacter calcoaceticus catechol 1,2-dioxygenase structural gene catA in Escherichia coli. (asm.org)
- Catechol 1,2-dioxygenase (EC 1.13.1.1), the product of the catA gene, catalyzes the first step in catechol utilization via the beta-ketoadipate pathway. (asm.org)
- When the catA-containing fragment was placed under the control of the lac promoter on pUC19 and induced with isopropylthiogalactopyranoside, catechol dioxygenase was formed in E. coli at twice the level found in fully induced cultures of A. calcoaceticus. (asm.org)
- Previously, catechol has been produced by transforming d -glucose with a genetically modified Escherichia coli AB2834/pKD136/pKD9.069A strain expressing 3-dehydroshikimic acid dehydratase and protocatechuic acid decarboxylase ( 10 , 11 ) and by benzene oxidation with Pseudomonas putida 6-12 expressing toluene/benzene dioxygenase while lacking catechol 1,2-oxygenase and catechol 2,3-oxygenase ( 25 ). (asm.org)
- Complex 1 displays the intradiol-cleaving dioxygenase activity, and the coordinate ethoxyl arm of the ligand is capable of accepting the proton from catechol, which mimics the function of Tyr447 in the. (diva-portal.org)
- Catechol 1,2-dioxygenase from α-naphthol degrading thermophilic Geobacillus sp. (semanticscholar.org)
- The purpose of this study was purification and characterization of catechol 1,2-dioxygenase from Geobacillus sp. (semanticscholar.org)
- The catechol 1,2-dioxygenase (C1,2O) was purified using four steps of ammonium sulfate precipitation, DEAE-celullose, Sephadex G-150 and hydroxylapatite chromatographies. (semanticscholar.org)
- Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens. (semanticscholar.org)
Inhibition2
- Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. (elsevier.com)
- Inhibition of catechol-O-methyltransferase by tolcapone has been shown to increase levodopa bioavailability and plasma elimination half life, thereby prolonging the efficacy of levodopa. (bmj.com)
Benzene5
- in 1867, August Kekulé realized that catechol was a diol of benzene, so by 1868, catechol was listed as pyrocatechol. (wikipedia.org)
- I have been interested in preparing Benzene-1,2-diol (catechol) for some time. (sciencemadness.org)
- It was discovered that toluene 4-monooxygenase (T4MO) of Pseudomonas mendocina KR1, toluene 3-monooxygenase (T3MO) of Ralstonia pickettii PKO1, and toluene ortho -monooxygenase (TOM) of Burkholderia cepacia G4 convert benzene to phenol, catechol, and 1,2,3-trihydroxybenzene by successive hydroxylations. (asm.org)
- At a concentration of 165 μM and under the control of a constitutive lac promoter, Escherichia coli TG1/pBS(Kan)T4MO expressing T4MO formed phenol from benzene at 19 ± 1.6 nmol/min/mg of protein, catechol from phenol at 13.6 ± 0.3 nmol/min/mg of protein, and 1,2,3-trihydroxybenzene from catechol at 2.5 ± 0.5nmol/min/mg of protein. (asm.org)
- Monooxygenases may be used to hydroxylate and remove benzene, but since phenol, the monohydroxylated product, is also listed as a priority pollutant, double hydroxylation of benzene to catechol is more efficient for combining bioremediation and biocatalysis. (asm.org)
Different catechol2
- Powder X-ray diffraction (XRD), X-ray photoelectron spectrum analysis (XPS), Fourier transform infrared spectra, thermogravimetric analysis, and UV-Vis diffuse reflectance spectra were carried out to characterize the composites with different catechol contents and different preparation temperatures. (deepdyve.com)
- The micelles were prepared from a hydrophilic poly(N-acryloyl morpholine) and a hydrophobic catechol-bearing block with different catechol content. (elsevier.com)
Catecholamine1
- Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (hmdb.ca)
Methyltransferase11
- Flohe L, Schwabe K-P. Kinetics of purified catechol- O -methyltransferase. (springer.com)
- The purification and properties of pig-liver catechol- O -methyltransferase. (springer.com)
- Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. (nih.gov)
- Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? (elsevier.com)
- 1992). Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1--q11.2. (salimetrics.com)
- No difference in the distribution of the catechol-O-methyltransferase genotypes (H/H, H/L, L/L) and alleles (H, L) was observed between the patients and the controls. (ovid.com)
- In addition, significant differences in the frequencies of the catechol-O-methyltransferase allele (χ2=4.481, df=1, P=0.040) were observed between the non-violent group and the controls. (ovid.com)
- Catechol-O-methyltransferase: a dual-role player in different breast cancer subtypes? (muni.cz)
- Ball P, Knuppen R, Breuer H (1971) Purification and properties of catechol-O-methyltransferase of human liver. (springer.com)
- Guldberg HC, Marsden CA (1975) Catechol-O-methyltransferase: Pharmacological aspects and physiological role. (springer.com)
- Belongs to the mammalian catechol-O-methyltransferase family. (mybiosource.com)
Block copolymer1
- This thesis describes novel catechol-functionalized multidentate block copolymer (Cat-MDBC) strategy that enables the stabilization of SNPs with diameter ≤3.5 nm as effective MR bright imaging (T1-weighted) contrast agents. (concordia.ca)
Substrate specificity1
- The other UGT enzymes (1A1, 1A6, 2B7, and 2B15) showed narrower substrate specificity for catechols, but each glucuronidated some catechols at a high rate. (aspetjournals.org)
Enzymes2
- Polymorphisms in maternal or offspring genes encoding estrogen-metabolizing enzymes may influence prenatal catechol estrogen levels and could therefore be biomarkers of TGCC risk. (aacrjournals.org)
- Hence, the rates of synthesis of catechol by both T3MO and T4MO and the 1,2,3-trihydroxybenzene formation rate by TOM were found to be comparable to the rates of oxidation of the natural substrate toluene for these enzymes (10.0 ± 0.8, 4.0 ± 0.6, and 2.4 ± 0.3 nmol/min/mg of protein for T4MO, T3MO, and TOM, respectively, at a toluene concentration of 165 μM). (asm.org)
Protein1
- Bio-inspired from the strong adhesion ability of mussel proteins, renewable and robust soy-based composite films were fabricated from two soybean-derived industrial materials: soluble soybean polysaccharide (SSPS) and catechol-functionalized soy protein isolate (SPI-CH). The conjugation of SPI with multiple catechol moieties as a versatile adhesive component for SSPS matrix efficiently improved the interfacial adhesion between each segment of biopolymer. (mdpi.com)
Conjugate acid1
- Catechol is the conjugate acid of a chelating agent used widely in coordination chemistry. (wikipedia.org)
Synthesis2
- Chapter three, describes the synthesis o f the mononuclear ruthenium (II) complexes of the protected catechol ligand 3-(r,2'-dim ethoxyphenyl)-5-(pyridin-2-yl)-l,2,4-triazole. (dcu.ie)
- These catechol complexes are precursors for the synthesis of dinuclear ruthenium complexes bound through the catechol binding site, the subject of chapter five, and for complexation of various other transition metals such as Fe(II), Fe(III) and Cu(II), the subject of chapter six. (dcu.ie)
Methyl1
- Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study. (painresearchforum.org)
Reaction7
- The reaction rate constants of the distinct charged particles, in which catechol(amine)s can appear, are proved to be independent of pH. (springer.com)
- PO activity was determined in a 96-well microplate in a total reaction volume of 300 [micro]L per well with catechol as the substrate, according to the method described by Benjamin & Montgomery (1913). (thefreedictionary.com)
- The reaction was rapid, independent of pH, and essentially complete within seconds under conditions of excess catechol at pH 4 to 6. (unl.edu)
- The catalytic constants for the reactions catalysed by acetic and formic acids are similar to those of the analogously catalysed hydrolyses of OO-(4-carboxybenzylidene) catechol, but the catalytic constant for the spontaneous reaction is ca. 30 times greater than that for spontaneous hydrolysis of the latter compound. (hud.ac.uk)
- This is attributed to nucleophilic assistance in reaction of OO-(2-carboxybenzylidene) catechol. (hud.ac.uk)
- The reaction of 1 and catechol in the presence of excess triethylamine gave the catecholate (CAT) chelate b is(u -al koxo) -bridged dinuclear iron(Ill) complex [Fe(L)(CAT)12 (2). (diva-portal.org)
- The reaction of catechol with the minerals listed above gave a water soluble silicon-catechol complex, Si (Cat)₃⁼, which was isolated as (CN₃H₆)₂[Si(Cat)₃]·H₂0 by adding guanidine hydrochloride to the reaction mixture after filtering. (pdx.edu)
Kinetics2
- Kinetics and Mechanism of Birnessite Reduction by Catechol" by Christopher J. Matocha, Donald L. Sparks et al. (unl.edu)
- The complex interactions of oxidizable organic ligands with soil Mn(III,IV) (hydr)oxide minerals have received little study by in situspectroscopic techniques.We used a combination of an in situ electron paramagnetic resonance stopped-flow (EPR-SF) spectroscopic technique and stirred-batch studies to measure the reductive dissolution kinetics of birnessite (δ-MnO 2 ), a common Mn mineral in soils, by catechol (1,2-dihydroxybenzene). (unl.edu)
Hydrolysis1
- Zhang, Jinlong 2013-10-05 00:00:00 TiO2 was in situ surface-modified in the hydrolysis of TBOT with catechol to improve its photocatalytic activity. (deepdyve.com)
Degradation1
- 2007) found out that the value of VFAs which was produced during catechol degradation in a UASB varied from 15 to 65 mg/l. (thefreedictionary.com)
Molecule1
- This natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels providing also the functionalized polymer with bioadhesion in the moist environment of the human body. (csic.es)
Oxidation of phenol1
- Currently, catechol is produced primarily by the oxidation of phenol and m -diisopropylbenzene or by coal-tar distillation ( 13 ). (asm.org)
Estrogen formation2
- Catechol estrogen formation in the mouse uterus and its role in implantation. (biomedsearch.com)
- We conducted a population-based, case-parent triad study ( 16 ) to test whether TGCC risk is related to maternal and/or offspring variation in genes involved in catechol estrogen formation ( CYP1A2, CYP1B1, CYP3A4 , and CYP3A5 ). (aacrjournals.org)
Reversible3
- The reversible boronate formation between electrochemically active substituted catechols and a fluorescent boronic acid was studied in methanol . (rsc.org)
- Reversible increases in catechol signal were observed during reversible increases in arterial partial CO2 pressure (PaCO2) from 20 to 60 mmHg after alteration of tidal volume (n = 5 intact rats, n = 5 after carotid sinus deafferentation). (biomedsearch.com)
- A reversible increase in inspiratory CO2 combined with constant tidal volume led to changes in PaCO2 from 40 mmHg to 50 or 60 or 70 mmHg for 60 min (n = 5 in each group) and to a reversible increase in catechol signal (r = 0.76). (biomedsearch.com)
Oxidative1
- The biomimetic adherent catechol moieties were successfully bonded in the polymeric network based on catechol crosslinking chemistry through simple oxidative coupling and/or coordinative interaction. (mdpi.com)
Aromatic3
- Urushiols are naturally existing organic compounds that have the catechol skeleton structure and diphenol functionality but with alkyl groups substituted onto the aromatic ring. (wikipedia.org)
- The effectiveness of catechol, an aromatic vic-diol, in dissolving silicate minerals was studied. (pdx.edu)
- The dissolution of these minerals by catechol to form Si(Cat)₃⁼ leads to the conclusion that aromatic vic-diols in nature may play a role in chemical weathering, in transport of silicon into rivers or seas, in soil development, in interconversion of minerals, and in accumulation of silica in plants. (pdx.edu)
Moieties4
- Catechol moieties are also found widely within the natural world. (wikipedia.org)
- Based on our results, we propose a new explanation for binding synergy between catechols and cations based on the relationship between solution conditions, bond lifetimes, and competitive binding of adhesive moieties to mica surfaces. (aiche.org)
- We recently reported antioxidant micelles having catechol moieties, a structural motif found among natural antioxidants. (elsevier.com)
- The micelles with higher catechol content formed stable spherical micelles and showed increased stability against auto-oxidation, while micellization did not affect the redox potential of catechol moieties. (elsevier.com)
Copolymers2
- To reach that goal, synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules with high yields. (csic.es)
- The results suggested that the promising way improved the phase adhesion of graft copolymers using catechol-functionalized polymers as versatile adhesive components. (mdpi.com)
Sensitivity1
- Sensitivity of the catechol signal, recorded in the rostral ventrolateral medulla, to CO2 appears primarily to be centrally mediated. (biomedsearch.com)