Catechols. Medical search

A group of 1,2-benzenediols that contain the general formula R-C6H5O2.

Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.

2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.

An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.

Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.

Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.

Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.

An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.

An antiseptic and disinfectant aromatic alcohol.

Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.

Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.

An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.

A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.

A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.

Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.

Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.

Derivatives of adipic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,6-carboxy terminated aliphatic structure.

Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.

A widely used industrial solvent.

Benzoic acid or benzoic acid esters substituted with one or more chlorine atoms.

A genus of coccoid bacteria in the family PLANOCOCCACEAE. They are widely distributed in various habitats including sea water, freshwater ponds, cyanobacterial mats, and in marine animals.

A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.

A genus of gram-negative, aerobic, motile bacteria that occur in water and soil. Some are common inhabitants of the intestinal tract of vertebrates. These bacteria occasionally cause opportunistic infections in humans.

A bacterial genus of the order ACTINOMYCETALES.

Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.

Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.

An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.

A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.

A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

Pigment obtained by the oxidation of epinephrine.

Salts and esters of gentisic acid.

The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.

A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.

A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.

Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)

A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.

A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)

The functional hereditary units of BACTERIA.

Action of 3 tyrphostin derivatives on casein kinase II from rat liver. (1/1002)

AIM: To study the action of tyrphostin on casein kinase (CK) II. METHODS: CK II was partially purified from rat livers by sequential DE52 and heparin-Sepharose chromatography. CK II activity was assayed by incubating CK II with dephosphorylated casein and [gamma-32P]ATP. RESULTS: AG34 inhibited the activity of CK II with IC50 33 (27-41) mumol.L-1. Both AG372 (121 mumol.L-1) and AG1112 (150 mumol.L-1) displayed inhibitory effects on the activity of CK II. Kinetic studies of AG34 on CK II showed that it was noncompetitive with casein and ATP. CONCLUSION: AG34, AG372, and AG1112 were potent inhibitors of CK II, and the inhibitory action of AG34 was noncompetitive with casein and ATP. (+info)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/1002)

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity. (+info)

Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (3/1002)

We identified and characterized a methyl transfer activity of the toluate cis-dihydrodiol (4-methyl-3,5-cyclohexadiene-cis-1, 2-diol-1-carboxylic acid) dehydrogenase of the TOL plasmid pWW0 towards toluene cis-dihydrodiol (3-methyl-4,5-cyclohexadiene-cis-1, 2-diol). When the purified enzyme from the recombinant Escherichia coli containing the xylL gene was incubated with toluene cis-dihydrodiol in the presence of NAD+, the end products differed depending on the presence of adenosylcobalamin (coenzyme B12). The enzyme yielded catechol in the presence of adenosylcobalamin, while it gave 3-methylcatechol in the absence of the cofactor. Adenosylcobalamin was transformed to methylcobalamin as a result of the enzyme reaction, which indicates that the methyl group of the substrate was transferred to adenosylcobalamin. Other derivatives of the cobalamin such as aquo (hydroxy)- and cyanocobalamin did not mediate the methyl transfer reaction. The dehydrogenation and methyl transfer reactions were assumed to occur concomitantly, and the methyl transfer reaction seemed to depend on the dehydrogenation. To our knowledge, the enzyme is the first dehydrogenase that shows a methyl transfer activity as well. (+info)

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. (4/1002)

Earlier study suggested that 3,4-dihydroxytamoxifen (tam catechol), a tamoxifen metabolite, is proximate to the reactive intermediate that binds covalently to proteins and possibly to DNA (). The current study demonstrates that rat and human hepatic cytochrome P-450s (CYPs) catalyze tam catechol formation from tamoxifen (tam), 3-hydroxy-tam (Droloxifene), and 4-hydroxy-tam (4-OH-tam). Higher levels of catechol were formed from 4-OH-tam and 3-hydroxy-tam than from tam. Evidence that human hepatic CYP3A4 and 2D6 catalyze the formation of tam catechol from 4-OH-tam and supportive data that the catechol is proximate to the reactive intermediate, was obtained: 1) There was a good correlation (r = 0.82; p +info)

Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats. (5/1002)

AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2. Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of 63Ni was shown by the whole-body autoradiography. RESULTS: CBMIDA s.c. 0.5-1.5 g.kg-1 markedly reduced the mortality from acute poisoning of i.p. NiCl2 500 mg.kg-1. After i.p. NiCl2 in mice, the LD50 was 82.7 mg.kg-1. Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively. The LD50 of NiCl2 was 39 mg.kg-1 in rat. If CBMIDA was injected i.m. 0.5 g.kg-1 after i.p. NiCl2, the LD50 was 332 mg.kg-1. CBMIDA 1.5 g.kg-1 i.m. after i.v. 63NiCl2, decreased the contents of 63Ni in blood and lung of mice vs control mice at 24 h. The contents of 63Ni in brain, heart, spleen, and kidney were similar to those of the control mice. The content of 63Ni in bone was more than the control. The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiography showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of 63Ni in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. There was a marked reduction of 63Ni in the lung, skin, liver, and blood after i.p. CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice and rats, and decreased 63Ni levels in lung and blood. (+info)

Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. (6/1002)

Two Escherichia coli transformants with catechol 1,2-dioxygenase activity were selected from a gene library of the benzamide-assimilating bacterium Arthrobacter species strain BA-5-17, which produces four catechol 1,2-dioxygenase isozymes. A DNA fragment isolated from one transformant contained a complete open reading frame (ORF). The deduced amino acid sequence of the ORF shared high identity with hydroxyquinol 1,2-dioxygenase. An enzyme expressed by the ORF was purified to homogeneity and characterized. When hydroxyquinol was used as a substrate, the purified enzyme showed 6.8-fold activity of that for catechol. On the basis of the sequence identity and substrate specificity of the enzyme, we concluded that the ORF encoded hydroxyquinol 1,2-dioxygenase. When catechol was used as a substrate, cis,cis-muconic acid and 2-hydroxymuconic 6-semialdehyde, which were products by the intradiol and extradiol ring cleavage activities, respectively, were produced. These results showed that the hydroxyquinol 1,2-dioxygenase reported here was a novel dioxygenase that catalyzed both the intradiol and extradiol cleavage of catechol. (+info)

Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (7/1002)

The inotropic/lusitropic effects of beta-adrenergic agonists on the heart are mediated largely by protein kinase A (PKA)-catalyzed phosphorylation of phospholamban, the natural protein regulator of the Ca2+ pump present in sarcoplasmic reticulum (SR) membranes. Gingerol, a plant derivative, is known to produce similar effects when tested in isolated cardiac muscle. The purpose of the present study was to compare the effects of gingerol and another plant derivative, ellagic acid, on the kinetics of the SR Ca2+ pump with those of PKA-catalyzed phospholamban phosphorylation to elucidate their mechanisms of Ca2+ pump regulation. As previously demonstrated for PKA, 50 microM gingerol or ellagic acid increased Vmax(Ca) of Ca2+ uptake and Ca2+-ATPase activity assayed at millimolar ATP concentrations in light cardiac SR vesicles. Unlike PKA, which decreases Km(Ca), neither compound had a significant effect on Km(Ca) in unphosphorylated vesicles. However, gingerol increased Km(Ca) in phosphorylated vesicles, in which Ca2+ uptake was significantly increased further at saturating Ca2+ and remained unchanged at subsaturating Ca2+. An inhibition of Ca2+ uptake by gingerol at micromolar MgATP concentrations was overcome with increasing MgATP concentrations. The stimulation of Ca2+ uptake attributable to gingerol in unphosphorylated microsomes at saturating Ca2+ was 30% to 40% when assayed at 0.05 to 2 mM MgATP and only about 12% in phosphorylated microsomes as well as in rabbit fast skeletal muscle light SR. The present results support the view that an ATP-dependent increase in Vmax(Ca) of the SR Ca2+ pump plays an important role in mediating cardiac contractile responses to gingerol and phospholamban-dependent beta-adrenergic stimulation. (+info)

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. (8/1002)

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. A polymorphism in NQO1, a C609T substitution, has been identified, and individuals homozygous for this change (T/T) have no detectable NQO1. Exposed workers with a T/T genotype have an increased risk of benzene hematotoxicity. This finding suggests NQO1 is protective against benzene toxicity, which is difficult to reconcile with the lack of detectable NQO1 in human bone marrow. The human promyeloblastic cell line, KG-1a, was used to investigate the ability of the benzene metabolite hydroquinone (HQ) to induce NQO1. A concentration-dependent induction of NQO1 protein and activity was observed in KG-1a cells cultured with HQ. Multiple detoxification systems, including NQO1 and glutathione protect against benzene metabolite-induced toxicity. Indeed, exposure to a noncytotoxic concentration of HQ induced both NQO1 and soluble thiols and protected against HQ-induced apoptosis. NQO1 protein and activity increased in wild-type human bone marrow cells (C/C) exposed to HQ, whereas no NQO1 was induced by HQ in bone marrow cells with the T/T genotype. Intermediate induction of NQO1 by HQ was observed in heterozygous bone marrow cells (C/T). NQO1 also was induced by HQ in wild-type (C/C) human bone marrow CD34(+) progenitor cells. Our data suggest that failure to induce functional NQO1 may contribute to the increased risk of benzene poisoning in individuals homozygous for the NQO1 C609T substitution (T/T). (+info)

Synthesis from catechol requires an additional step, Williamson ether synthesis using dichloromethane. Piperonal, like all ... Piperonal can be prepared by oxidizing isosafrole or by using a multistep sequence from catechol or 1,2-methylenedioxybenzene. ... doi:10.1016/S0040-4039(00)88578-0. Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the ...

https://en.wikipedia.org/wiki/Piperonal

doi:10.2174/1389200003339270 Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the Chemical ... 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes. 1,4-Benzodioxine Methylenedioxy Safrole ...

https://en.wikipedia.org/wiki/1,3-Benzodioxole

Catechol, for example, is synthesized from o-hydroxy and o-alkoxy phenyl aldehydes and ketones, and is used as the starting ... Dakin, H.D. (1923). "Catechol". Organic Syntheses. 3: 28. doi:10.15227/orgsyn.003.0028. Surrey, Alexander R. (1946). " ...

https://en.wikipedia.org/wiki/Dakin_oxidation

Dakin, H. D. (1923). "Catechol" (PDF). Organic Syntheses. 3: 28. ; Collective Volume, 1, p. 149 Burgstahler, A. W.; Worden, L. ... Salicylaldehyde is used to make the following: Oxidation with hydrogen peroxide gives catechol (1,2-dihydroxybenzene) (Dakin ...

https://en.wikipedia.org/wiki/Salicylaldehyde

In the case the catecholamines, however, the enzymes of degradation monoamine oxidase and catechol-O-methyl transferase, like ... In this respect, ″amino-ethanol-catechol″ - noradrenaline - mimicked sympathetic nerves more closely than adrenaline did. The ... Julius Axelrod (1962). "O-Methylation of epinephrine and other catechols". Science. 126 (3270): 400-401. doi:10.1126/science. ... noradrenaline and adrenaline were O-methylated by catechol-O-methyl transferase. To fill the gap completely, however, the role ...

https://en.wikipedia.org/wiki/History_of_catecholamine_research

Catechol-O-methyltransferase (COMT) degrades a class of molecules known as catcholamines that includes dopamine, epinephrine, ... "COMT catechol-O-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. Ragsdale, S.W. "Catalysis of ... Examples include: Catechol-O-methyl transferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate- ...

https://en.wikipedia.org/wiki/Methyltransferase

... catechol oxidases). A mixture of monophenol oxidase and catechol oxidase enzymes is present in nearly all plant tissues, and ... catechol oxidase "Polyphenol Oxidase". Worthington Enzyme Manual. Retrieved 13 September 2011. Mayer, AM (November 2006). " ...

https://en.wikipedia.org/wiki/Polyphenol_oxidase

other dioxygenase: Catechol dioxygenase. *Homogentisate 1,2-dioxygenase. *Cysteine dioxygenase. *4-Hydroxyphenylpyruvate ...

https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase

Catechol metabolite. Elimination half-life. 17.5 hours. Excretion. Feces (~61%), urine (~36%)[1]. ...

https://en.wikipedia.org/wiki/Tadalafil

other dioxygenase: Catechol dioxygenase. *Homogentisate 1,2-dioxygenase. *Cysteine dioxygenase. *4-Hydroxyphenylpyruvate ...

https://en.wikipedia.org/wiki/1,2-dihydroxynaphthalene_dioxygenase

... allowing siderocalin to bind to the iron-catechol complex. Catechols can be bound by siderocalin, in the form of free ligands, ... Mammalian siderophores, specifically catechols, can be found in the human gut and in siderophores, such as enterobactin, and ... Catechol resembling molecules can act as iron ligands in the cell and in systematic circulation, ... Rogers HJ (Mar 1973). "Iron-Binding Catechols and Virulence in Escherichia coli". Infection and Immunity. 7 (3): 445-56. PMC ...

https://en.wikipedia.org/wiki/Siderocalin

... the catechol-type siderophores, agrobactin; and the mixed ligand catechol-hydroxamate-hydroxy acid siderophores biosynthesized ...

https://en.wikipedia.org/wiki/Siderophore

Catechol-O-methyl transferase (COMT). A large number of natural products in plants, e.g. lignins, are generated via catalysis ...

https://en.wikipedia.org/wiki/Methoxy_group

Kobayashi S, Hayaishi O (1970). "Anthranilic acid conversion to catechol (Pseudomonas)". Methods Enzymol. 17A: 505-510. doi: ... catechol + CO2 + NAD(P)+ + NH3 The 5 substrates of this enzyme are anthranilate, NADH, NADPH, H+, and O2, whereas its 5 ... "Enzymatic formation of catechol from anthranilic acid". J. Biol. Chem. 239: 2204-2211. PMID 14209949. Molecular and Cellular ... products are catechol, CO2, NAD+, NADP+, and NH3. This enzyme belongs to the family of oxidoreductases, specifically those ...

https://en.wikipedia.org/wiki/Anthranilate_1,2-dioxygenase_(deaminating,_decarboxylating)

3. Enzymes of the catechol pathway". J. Biol. Chem. 241: 3795-3799. PMID 5330966. Ornston, L.N. (1970). "Conversion of catechol ... Ornston, L.N. (1966). "The conversion of catechol and protocatechuate to β-ketoadipate by Pseudomonas putida. ... catechol and protocatechuate, to citric acid cycle intermediates as a part of the β-ketoadipate pathway in soil microbes. Some ...

https://en.wikipedia.org/wiki/Muconate_lactonizing_enzyme

... is a major metabolite of L-3,4-dihydroxyphenylalanin (L-DOPA) and is formed by catechol O-methyltransferase ( ... This process is catalyzed by catechol O-methyltransferase methylates (COMT). The action of the enzyme makes it possible the ... Tai, C. H.; Wu, R. M. (2002). "Catechol-O-methyltransferase and Parkinson's disease". Acta medica Okayama. 56 (1): 1-6. PMID ... L-DOPA Entacapone Tolcapone Catechol-O-methyl transferase Parkinson's disease Parkinson's Disease and movement disorders. ...

https://en.wikipedia.org/wiki/3-O-Methyldopa

3. Enzymes of the catechol pathway". J. Biol. Chem. 241 (16): 3795-9. PMID 5330966. Ornston LN (1970). "Conversion of catechol ... Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. ...

https://en.wikipedia.org/wiki/Muconolactone_Delta-isomerase

I Enzymatic formation of catechol from benzene". Biochemistry. 7 (7): 2653-62. doi:10.1021/bi00847a031. PMID 4298226. Molecular ... catechol + NADH + H+ Thus, the two substrates of this enzyme are cis-1,2-dihydrobenzene-1,2-diol and NAD+, whereas its 3 ... products are catechol, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH- ...

https://en.wikipedia.org/wiki/Cis-1,2-dihydrobenzene-1,2-diol_dehydrogenase

... s are much broader than the oligomers of ethylene oxide; an important group are derived from catechol. Crown ethers ...

https://en.wikipedia.org/wiki/Crown_ether

... see catechol), and myrobalans from Terminalia spp., such as Terminalia chebula. Hides are stretched on frames and immersed for ...

https://en.wikipedia.org/wiki/Tanning_(leather)

Allyl cyanide is starting material, and catechol. Idazoxan Piperoxan David J. Triggle (1997). Dictionary of pharmacological ...

https://en.wikipedia.org/wiki/Azaloxan

I Enzymatic formation of catechol from benzene". Biochemistry. 7 (7): 2653-62. doi:10.1021/bi00847a031. PMID 4298226. Molecular ...

https://en.wikipedia.org/wiki/Benzene_1,2-dioxygenase

... is produced by methylation of catechol; e.g., using potash and dimethyl sulfate: C6H4(OH)2 + (CH3O)2SO2 → C6H4(OH)( ... Guaiacol can be synthesized by the dimethylation of catechol followed by selective mono-demethylation. C6H4(OCH3)2 + C2H5SNa → ...

https://en.wikipedia.org/wiki/Guaiacol

M. L. Tainter (1930). "Comparative actions of sympathomimetic compounds: catechol derivatives." J. Pharmacol. Exp. Ther. 40 43- ... "methylamino-ethyl-catechol", as they called it, had about 1/7 x the pressor potency of epinephrine, but about 5 x the potency ... "methylamino-ethyl-catechol", under the name "epinine", as a substitute for epinephrine. Tainter further quantified the pressor ... of dopamine ("amino-ethyl-catechol") in cat preparations. The Buroughs Wellcome Co., for which Barger, Dale and Pyman (see " ...

https://en.wikipedia.org/wiki/Deoxyepinephrine

Michnovicz JJ, Galbraith RA (February 1991). "Cimetidine inhibits catechol estrogen metabolism in women". Metabolism. 40 (2): ...

https://en.wikipedia.org/wiki/Cimetidine

Catechol melanins,. Flavolans (Condensed tannins),. Polyphenolic proteins, Polyphenols Raspberry ellagitannin, Tannic acid ...

https://en.wikipedia.org/wiki/Natural_phenol

Kupchan demonstrated that taxodone aromatizes to a catechol ketone upon exposure to mild acid. Air oxidation of this catechol ... "Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons ...

https://en.wikipedia.org/wiki/Taxodone

... is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about ...

https://en.wikipedia.org/wiki/Pirbuterol

Catechol borane is less reactive than borane itself. When catecholborane is treated with an alkyne, usually a terminal alkyne, ... Unlike borane itself or alkylboranes, catechol borane exists as a monomer. This behavior is a consequence of the electronic ... This colourless liquid is a derivative of catechol and a borane, having the formula C6H4O2BH. Traditionally catecholborane is ... produced by treating catechol with borane (BH3) in a cooled solution of THF. However, this method results in a loss of 2 mole ...

https://en.wikipedia.org/wiki/Catecholborane

... which mediates the electron transfer between catechol substrates and O2 to form a [M(II)(semiquinone)superoxo] intermediate. ... "Characterization of an O2 Adduct of an Active Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase". Journal of the ... "A Hyperactive Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase". Journal of biological inorganic chemistry : JBIC : a ...

https://en.wikipedia.org/wiki/Lawrence_Que_Jr.

Solubility in water: 430g/L (20°C). Other solubilities: soluble in alcohol, benzene, chloroform, ether, and pyridine and aqueous solutions ...

https://www.fishersci.ca/shop/products/catechol-99-acros-organics-4/AC158980100

In the process, catechol was oxidized to the two-electron o-quinone product. The energy of activation (Ea) for the reaction was ... Rates of catechol disappearance from solution with simultaneous Mn(II) and o-quinone production were comparable. These data ... The rapid reductive dissolution of birnessite by catechol has significant implications for C and Mn cycling in soils and the ... by catechol (1,2-dihydroxybenzene). The reaction was rapid, independent of pH, and essentially complete within seconds under ...

https://digitalcommons.unl.edu/usdoepub/172/

"In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates" on DeepDyve, ... In situ surface modification of colloidal TiO2 nanoparticles with catechol. Zhang, Boyuan; Zou, Weiwei; Zhang, Jinlong ... Through XPS analyses, it was confirmed that the catechol was anchored and saturated on the TiO2 surface by reacting with the ... In situ surface modification of colloidal TiO2 nanoparticles with catechol Zhang, Boyuan; Zou, Weiwei; Zhang, Jinlong 2013-10- ...

https://www.deepdyve.com/lp/springer_journal/in-situ-surface-modification-of-colloidal-tio2-nanoparticles-with-q7pJPYRtEk

Drugs Metabolized By Catechol-O-Methyltransferase (COMT). See WARNINGS.. Hormone Levels. Levodopa is known to depress prolactin ... Drugs Metabolized By Catechol-O-Methyltransferase (COMT). When a single 400 mg dose of entacapone was given with intravenous ... Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinsons disease as an adjunct ... The function of COMT is the elimination of biologically active catechols and some other hydroxylated metabolites. In the ...

https://www.rxlist.com/comtan-drug.htm

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease ... Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease. Aging and ...

https://dcyphr.org/history/292

Lih, E., Choi, S. G., Ahn, D. J., Joung, Y. K., & Han, D. K. (2016). Optimal conjugation of catechol group onto hyaluronic acid ... Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis ... Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis ... Lih, E, Choi, SG, Ahn, DJ, Joung, YK & Han, DK 2016, Optimal conjugation of catechol group onto hyaluronic acid in coronary ...

https://koreauniv.pure.elsevier.com/en/publications/optimal-conjugation-of-catechol-group-onto-hyaluronic-acid-in-cor

Catechol 2,3-dioxygenase (xylE) is found in Pseudomonas putida and hydrolyzes catechol into 2-HMS, which can enter the citric ... Fluorene, anthracene and naphthalene can be degraded into catechol using a series of enzymatic steps (orange). Catechol can be ... which can be further degraded to catechol. The ability to degrade these chemicals to catechol will complement the prototype kit ... Catechol as the entry point into Escherichia coli metabolism. To address the decontamination of (1) toxic organic compounds ...

http://2011.igem.org/wiki/index.php?title=Team:Lethbridge/Project&diff=prev&oldid=263237

... as well as monochlorinated catechols (39), potentially permitting the mineralization of multiply chlorinated aromatics. FIG. 1 ...

http://www.globaltechbiz.com/2017/10/16/the-gene-cluster-coding-for-the-chlorocatechol-sp-of-hereditary-biochemical/

Unscramble pyrocatechol, Unscramble letters pyrocatechol, Point value for pyrocatechol, Word Decoder for pyrocatechol, Word generator using the letters pyrocatechol, Word Solver pyrocatechol, Possible Scrabble words with pyrocatechol, Anagram of pyrocatechol

http://www.allscrabblewords.com/word-description/pyrocatechol

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations ...

http://www.ilo.org/dyn/icsc/showcard.display?p_lang=en&p_card_id=0411&p_version=2

... has role plant metabolite (CHEBI:76924) catechol (CHEBI:18135) is a catechols (CHEBI:33566) catechol ( ... catechol (CHEBI:18135) has role allelochemical (CHEBI:62215) catechol (CHEBI:18135) has role genotoxin (CHEBI:50902) ... catechol β-D-glucuronide (CHEBI:133689) has functional parent catechol (CHEBI:18135). guaiacol (CHEBI:28591) has functional ... aspalathin (CHEBI:79078) is a catechol (CHEBI:18135). caffeyl alcohol (CHEBI:86071) is a catechol (CHEBI:18135). droxidopa ( ...

http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18135

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in ... Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and ...

https://en.wikipedia.org/wiki/Catechol_estrogen

In plants, catechol oxidase plays a key role in enzymatic browning by catalyzing the oxidation of catechol to o-quinone in the ... As catechol enters the active site, a proton is abstracted from one of the alcohols. The catechol coordinates with a Cu(II) ... The coordinated hydroxide ion abstracts another proton from catechol to form water, and the catechol is oxidized to o-quinone. ... In this state, the enzyme active site is in a ternary catechol oxidase-O22−-catechol complex. Two electrons are transferred ...

https://en.wikipedia.org/wiki/Catechol_oxidase

1,2-Benzenediol, o-Benzenediol, 1,2-Dihydroxybenzene, o-Dihydroxybenzene, 2-Hydroxyphenol, Pyrocatechol Colorless, crystalline solid with a faint odor. [Note: Discolors to brown in air & light.]

https://www.cdc.gov/niosh/npg/npgd0109.html

A literature search was conducted through February 2018 to identify catechol toxicokinetics, acute toxicity, repeated-dose ... of the potential health effects of dermal exposure to catechol and the potential for direct skin injuries from catechol. ... assignment for catechol. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence ... or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to catechol. The criteria for the ...

https://www.cdc.gov/niosh/docs/2019-118/default.html

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C12H20O2Si/c1-12

The reaction rate constants of the distinct charged particles, in which catechol(amine)s can appear, are... ... The autoxidation of nine catecholamines and two catechols as a function of pH was studied. ... The purification and properties of pig-liver catechol-O-methyltransferase. Eur J Biochem 1978;88:439-44.PubMedGoogle Scholar ... Flohe L, Schwabe K-P. Kinetics of purified catechol-O-methyltransferase. Biochim Biophys Acta 1970;220:469-76.PubMedGoogle ...

https://link.springer.com/article/10.1007%2FBF01959197

2006). Catechol-. Breast Cancer Research and Treatment, 99(2), 235-240.. Abstract. The gene encoding catechol-O- ... Catechol-. Citation. Gaudet, Mia M.; Bensen, Jeannette T.; Schroeder, Jane C.; Olshan, Andrew F.; Terry, Mary Beth; Eng, Sybil ... methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide ...

https://www.cpc.unc.edu/resources/publications/bib/2984/

Patterns of plasma levels of catechols in neurogenic orthostatic hypotension.. Goldstein DS1, Polinsky RJ, Garty M, Robertson D ... Plasma levels of catechols were normal in most patients with multiple system atrophy, consistent with relatively intact ... The results demonstrate the value of examining patterns of plasma levels of catechols to elucidate mechanisms of neurogenic ... most patients with pure autonomic failure had decreased levels of all four catechols, consistent with degenerative loss of ...

https://www.ncbi.nlm.nih.gov/pubmed/2510587?dopt=Abstract

This topic has 11 study abstracts on Catechols indicating that they may have therapeutic value in the treatment of Brain ... Substances : 5-hydroxytryptamides, Caffeine, Catechols, Chlorogenic Acid, Coffee, N-methylpyridinium, Pyrogallol, Trigonelline ... Catechols have anti-inflammatory effects in lipopolysaccharide-stimulated microglia cells, inhibiting neurotoxicity. Jun 24, ... Substances : Acacia catechu, Catechols. Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide- ...

http://www.greenmedinfo.com/substance/catechols

Catechol monoallyl ether To stirred catechol (44 g.; 0.4 mole), dry acetone (125 ml.) and freshly fused potassium carbonate ( ... In all cases both mono- and diallyl ethers of catechol were formed. The catechol monoallyl ether on rearrangement gave 3- and 4 ... Hence, it was decided to condense acrylic acid with catechol using polyphosphoric acid to get acryloyl catechol and then ... From the residue consisting of unreacted catechol, potassium carbonate and potassium bromide, catechol (9.9 g.) was recovered ...

https://www.erowid.org/archive/rhodium/chemistry/allylcatechol.html

Estrogens, catechol synonyms, Estrogens, catechol pronunciation, Estrogens, catechol translation, English dictionary definition ... of Estrogens, catechol. also oes·tro·gen n. 1. Any of several steroid hormones, such as estradiol and estrone, that are ... redirected from Estrogens, catechol). Also found in: Thesaurus, Medical, Encyclopedia. es·tro·gen. also oes·tro·gen (ĕs′trə-jən ... Estrogens, catechol - definition of Estrogens, catechol by The Free Dictionary https://www.thefreedictionary.com/Estrogens%2c+ ...

http://www.thefreedictionary.com/Estrogens%2C+catechol

... (meta ring cleavage). When cursor points to a box further details will be displayed in a tooltip window. If ... catechol biosynthesis. EC 1.2.1.10 acetaldehyde dehydrogenase (acetylating). EC 1.2.1.85 2-hydroxymuconate-6-semialdehyde ... EC 1.13.11.2 catechol 2,3-dioxygenase. EC 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase. EC 4.1.1.77 4-oxalocrotonate ...

https://www.qmul.ac.uk/sbcs/iubmb/enzyme/reaction/misc/catechol.html

Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase.. Tsao D1, Diatchenko L, Dokholyan NV. ... Using catechol O-methyltransferase (COMT) as a model, we perform discrete molecular dynamics and computational docking ...

https://www.ncbi.nlm.nih.gov/pubmed/21904625

catechol estrogen(s);. CE-Q,. catechol estrogen quinone(s);. DMF,. dimethylformamide;. DMSO,. dimethyl sulfoxide;. E1,. estrone ... Covalent Binding of 4-Hydroxy Catechol Estrogens and Their Quinones to DNA.. E1-3,4-Q or E2-3,4-Q (1 mg/50 μl of DMSO) was ... Furthermore, the hexestrol catechol is activated by HRP, LP, or cytochrome P450 to form an N7Gua adduct (ref. 28 and S. T. Jan ... Carcinogenicity of Catechol Estrogens and Their Quinones in B6C3F1 Mice.. Litters of B6C3F1 mice were obtained from cross- ...

https://www.pnas.org/content/94/20/10937?ijkey=eb03f880b355dad4564ee7f0c60331c4567fc4d1&keytype2=tf_ipsecsha

catechol estrogen(s);. CE-Q,. catechol estrogen quinone(s);. DMF,. dimethylformamide;. DMSO,. dimethyl sulfoxide;. E1,. estrone ... Catechol-O-Methyltransferase (COMT)-mediated Metabolism of Catechol Estrogens: Comparison of Wild-Type and Variant COMT ... Covalent Binding of 4-Hydroxy Catechol Estrogens and Their Quinones to DNA.. E1-3,4-Q or E2-3,4-Q (1 mg/50 μl of DMSO) was ... Furthermore, the hexestrol catechol is activated by HRP, LP, or cytochrome P450 to form an N7Gua adduct (ref. 28 and S. T. Jan ...

https://www.pnas.org/content/94/20/10937

X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of ... CATECHOL O-METHYLTRANSFERASE, SOLUBLE FORM A 221 Rattus norvegicus EC#: 2.1.1.6 IUBMB Gene Name(s): Comt ...

http://www.rcsb.org/pdb/explore/litView.do?structureId=1JR4

O-Methylation of Epinephrine and Other Catechols in vitro and in vivo ... O-Methylation of Epinephrine and Other Catechols in vitro and in vivo ... O-Methylation of Epinephrine and Other Catechols in vitro and in vivo ... O-Methylation of Epinephrine and Other Catechols in vitro and in vivo ...

http://science.sciencemag.org/content/126/3270/400

An understanding of catechol-cation binding synergy should aid the design of biologically inspired adhesives for medical, ... To further study catechol-cation binding synergy, small molecules were synthesized with systematically varying intramolecular ... Previous work has shown that molecules containing both catechols and cations adhere to inorganic surfaces with higher adhesion ... we propose a new explanation for binding synergy between catechols and cations based on the relationship between solution ...

https://www.aiche.org/conferences/aiche-annual-meeting/2018/proceeding/paper/497f-explaining-catechol-cation-binding-synergy-bond-energies-and-lifetimes

It has been found that when the process of conversion of phenol to a mixture of hydroquinone and catechol is carried out in ... This invention relates to an improved process for the conversion of phenol to a mixture of hydroquinone and catechol. In ... an object of this invention to provide an improved process for the oxidation of phenol to hydroquinone and catechol wherein the ... production of the undesired by product tar is suppressed leading thereby to enhanced yields of hydroquinone and catechol. not ...

https://americans-world.org/docs/friyy.php?700a45=phenol-to-catechol-conversion

This article reports the striking interplay between the molecular structure and the photodissociation dynamics of catechol (a ... catechol. , D0(H-catechoxyl) ≤ 27 480 ± 50 cm−1, ∼2500 cm−1 lower than that of the sole O-H bond in bare phenol. . As a ... catechol. during ultraviolet photolysis G. A. King, T. A. A. Oliver, R. N. Dixon and M. N. R. Ashfold, Phys. Chem. Chem. Phys. ... catechol. is reduced relative to that in phenol. , yielding a particularly broad distribution of product vibrations for λphot ...

https://pubs.rsc.org/en/Content/ArticleLanding/2012/CP/c2cp22642a

... was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. Compared to bare ... MCPE shows good electrocatalytic activity towards the oxidation of catechol in phosphate buffer solution (PBS) of physiological ... By increasing the concentration of catechol, goes on increasing with shifting towards positive side. The graph of versus ... L. A. Alshahrani, X. Li, H. Luo et al., "The simultaneous electrochemical detection of catechol and hydroquinone with [Cu(Sal-β ...

https://www.hindawi.com/journals/apc/2016/8092860/

Purchase Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors, Volume 95 - 1st Edition ... Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors, Volume 95 1st Edition. 0.0 star ... Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinsons ... Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors ...

https://www.elsevier.com/books/basic-aspects-of-catechol-o-methyltransferase-and-the-clinical-applications-of-its-inhibitors/nissinen/978-0-12-381326-8

Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk. Katja Mitrunen, Nadejda Jourenkova, Vesa Kataja, Matti ... Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk. Katja Mitrunen, Nadejda Jourenkova, Vesa Kataja, Matti ... Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk. Katja Mitrunen, Nadejda Jourenkova, Vesa Kataja, Matti ... Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk Message Subject (Your Name) has forwarded a page to you ...

https://cebp.aacrjournals.org/content/10/6/635

... an analogue guest molecule lacking catechol functionality, to confirm the effect of catechols at the surface (Fig. S2†). On UPy ... electrostatic interactions or metal-catechol coordination.9 Once exposed to oxygen, catechol residues are oxidized to reactive ... a low concentration of catechols was able to induce increased fibroblast adhesion at the surface of nanofibers (catechol ... Supramolecular surface functionalization via catechols for the improvement of cell-material interactions†. S. Spaans ab, P. P. ...

http://pubs.rsc.org/en/content/articlehtml/2017/bm/c7bm00407a

Inhibitors of Catechol-O-Methyltransferase. Author(s): James C. Barrow. Lieber Institute for Brain Development, 336 John G. ... Keywords:Catechol-O-methyltransferase, COMT, dopamine, L-DOPA, Parkinsons disease, nitrocatechol, MB-COMT, SAM Binding, HPLC, ... Keywords: Catechol-O-methyltransferase, COMT, dopamine, L-DOPA, Parkinsons disease, nitrocatechol, MB-COMT, SAM Binding, HPLC ... Since the identification of Catechol-O-Methyltransferase (COMT) by Axelrod in 1957, many inhibitors of this enzyme have been ...

http://www.eurekaselect.com/98421/article

... possessed reliable analytical performance for the detection of catechol. The sensitivity of the Cu/CNFs/Lac/Nafion/GCE reached ... Laccase Biosensor Based on Electrospun Copper/Carbon Composite Nanofibers for Catechol Detection. Jiapeng Fu. ... "Laccase Biosensor Based on Electrospun Copper/Carbon Composite Nanofibers for Catechol Detection." Sensors 14, no. 2: 3543-3556 ... Keywords: electrospinning; copper/carbon composite nanofibers; laccase biosensor; catechol detection; electrochemical ...

http://www.mdpi.com/1424-8220/14/2/3543/xml

Furukawa S., Nitta A., Furukawa Y. (2002) Stimulation of Neurotrophin Synthesis by 4-Methyl Catechol: An Approach to the ... Stimulation of Neurotrophin Synthesis by 4-Methyl Catechol: An Approach to the Treatment of Neurodegeneration. ...

https://link.springer.com/chapter/10.1007/978-1-4757-3538-3_54

Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson's disease as an adjunct to levodopa and carbidopa therapy. (rxlist.com)

Rates of catechol disappearance from solution with simultaneous Mn(II) and o -quinone production were comparable. (unl.edu)

The reaction was rapid, independent of pH, and essentially complete within seconds under conditions of excess catechol at pH 4 to 6. (unl.edu)
Therefore, a series of dopamine-conjugated hyaluronic acid conjugates with different ratios of catechol group were synthesized via a carbodiimide coupling reaction. (elsevier.com)

Kinetics and Mechanism of Birnessite Reduction by Catechol" by Christopher J. Matocha, Donald L. Sparks et al. (unl.edu)

The rapid reductive dissolution of birnessite by catechol has significant implications for C and Mn cycling in soils and the availability of Mn to plants. (unl.edu)

Results showed that TiO2 nanoparticles were chemically modified by catechol leading to the shifting of the onset wavelength of the optical absorption in the visible range. (deepdyve.com)
Obtained results demonstrated that optimal amounts of catechol group (100 µmol) in the dopamine-conjugated hyaluronic acid existed in terms of various properties such as hemocompatibility and cellular responses. (elsevier.com)

In the process, catechol was oxidized to the two-electron o -quinone product. (unl.edu)

Zhang, Jinlong 2013-10-05 00:00:00 TiO2 was in situ surface-modified in the hydrolysis of TBOT with catechol to improve its photocatalytic activity. (deepdyve.com)

The optimum preparation condition was found at a weight ratio of 4.0 wt% (catechol/TiO2). (deepdyve.com)

Through XPS analyses, it was confirmed that the catechol was anchored and saturated on the TiO2 surface by reacting with the surface hydroxyl to form a bidentate mononuclear structure. (deepdyve.com)

The complex interactions of oxidizable organic ligands with soil Mn(III,IV) (hydr)oxide minerals have received little study by in situspectroscopic techniques.We used a combination of an in situ electron paramagnetic resonance stopped-flow (EPR-SF) spectroscopic technique and stirred-batch studies to measure the reductive dissolution kinetics of birnessite (δ-MnO 2 ), a common Mn mineral in soils, by catechol (1,2-dihydroxybenzene). (unl.edu)

The catechol estrogens are endogenous metabolites of estradiol and estrone and include the following compounds: 2-Hydroxylated: 2-Hydroxyestradiol 2-Hydroxyestrone 2-Hydroxyestriol 4-Hydroxylated: 4-Hydroxyestradiol 4-Hydroxyestrone 4-Hydroxyestriol The most abundant catechol estrogen in serum and urine is 2-hydroxyestrone, with 2-hydroxyestradiol and 2-hydroxyestriol also being formed, while the principal 4-hydroxy catechol estrogen, 4-hydroxyestrone, is present in only small amounts in urine. (wikipedia.org)
Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and semiquinones, and this has been hypothesized to contribute to estrogen-induced carcinogenesis. (wikipedia.org)
Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. (wikipedia.org)
2-Hydroxylated catechol estrogens are weak and possibly antiestrogenic estrogens, whereas their 4-hydroxylated counterparts are more potent in their estrogenic activity. (wikipedia.org)
For instance, 2-hydroxyestrone reportedly shows negligible uterotrophic effect in animals, whereas 4-hydroxy catechol estrogens show moderate changes in stimulating uterine weight. (wikipedia.org)
This relationship led us to postulate that oxidation of the carcinogenic 4-hydroxy catechol estrogens (CE) of estrone (E 1 ) and estradiol (E 2 ) to catechol estrogen-3,4-quinones (CE-3, 4-Q) results in electrophilic intermediates that covalently bind to DNA to form depurinating adducts. (pnas.org)
This relationship led us to postulate that oxidation of catechol estrogens (CE) to CE quinones (CE-Q) results in electrophilic intermediates that also covalently bind to DNA and form depurinating adducts. (pnas.org)
In contrast to free-formed catechol estrogens, the [C. (thefreedictionary.com)
differences between phenol and Catechol estrogens. (thefreedictionary.com)
Catechol (hydroxylated) estrogens have carcinogenic potential, thought to arise from reactive catechol intermediates with enhanced capability of forming mutation-inducing DNA adducts. (aacrjournals.org)
One mechanism by which in utero exposure to estrogens may influence the development of TGCC is via the effects of catechol metabolites of 17β-estradiol (E2) and estrone: 4-OH E2, 4-OH estrone, 2-OH E2, and 2-OH estrone. (aacrjournals.org)
Catechol estrogens, which are produced by cytochrome P 450 (CYP)-catalyzed hydroxylation of estrogens, readily undergo redox cycling between semiquinone and quinone forms through which reactive oxygen species (ROS) are produced. (aacrjournals.org)
Mammalian adult male germ cells and supporting gonadal tissues are highly susceptible to the toxic effects of ROS ( 9 - 12 ), and catechol estrogens seem to be involved in some of these toxic effects ( 13 , 14 ). (aacrjournals.org)
Catechol estrogens and/or oxidative damage resulting from maternal sources could also contribute to testicular carcinogenesis in utero . (aacrjournals.org)
Variation in maternal or offspring genes encoding estrogen-metabolizing enzymes could influence the level of exposure to prenatal catechol estrogens and could therefore serve as biomarkers in a retrospective study of hormonal risk factors for TGCC. (aacrjournals.org)
Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. (cdc.gov)

1996). Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. (salimetrics.com)
Catechol-O-methyltransferase, which has a functional genetic polymorphism, plays an important role in dopamine metabolism. (ovid.com)
The study analyzed the association between the catechol-O-methyltransferase gene polymorphism and alcohol dependence in the Korean population. (ovid.com)
Polymerase chain reaction-based genotyping was used to verify the presence of the catechol-O-methyltransferase gene polymorphism. (ovid.com)
This suggests that the catechol-O-methyltransferase gene polymorphism is not associated with the development of alcohol dependence, but may affect the susceptibility to a clinical heterogeneity of alcohol dependence, at least in the Korean population. (ovid.com)
No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population. (ebscohost.com)
Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users. (nispa.nl)
A functional single nucleotide polymorphism (a common normal variant) of the gene for catechol-O-methyl transferase has been shown to affect cognitive tasks broadly related to executive function, such as set shifting, response inhibition, abstract thought, and the acquisition of rules or task structure. (chemeurope.com)

Structural equation modeling was applied to data on 704 Norwegian children to test whether the catechol-O-methyltransferase Val158Met genotype moderates the effect of disorganized attachment, which was measured dimensionally at 4 years of age using the Manchester Child Attachment Story Task, on changes in aggressive behavior and social competence from ages 4 to 6. (samforsk.no)
The influence of Catechol-O-Methyltransferase Val158Met on fear of pain and placebo analgesia. (painresearchforum.org)

10,11 Catechol functionalities can be introduced by immersing material substrates in an alkaline solution of 3,4-dihydroxyphenethylamine (dopamine). (rsc.org)
To prevent the use of excessive dopamine, catechols can be directly coupled to synthetic polymers using dopamine or 3,4-dihydroxyhydrocinnamic acid, resulting in the formation of amide bonds. (rsc.org)
Kaakkola S, Wurtman R (1993) Effects of catechol-O-methyltransferase inhibitors and 1-3, 4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. (springer.com)
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. (mybiosource.com)
Catechol- O -methyl transferase is involved in the inactivation of the catecholamine neurotransmitters ( dopamine , epinephrine , and norepinephrine ). (chemeurope.com)
The invention relates generally to an improved method of synthesizing acetonide-protected catechol-containing molecules such as DOPA and dopamine. (justia.com)
Catechol-containing molecules such as DOPA and dopamine are important compounds with widely useful effects as therapeutic agents. (justia.com)
Acetonide-protected catechol-containing compounds such as DOPA and dopamine are useful in many applications, including Fmoc peptide synthesis and conjugating DOPA and dopamine with other small molecules, polymers, or macromolecules of interest. (justia.com)
As a member of the catecholamine family, 4-(2-aminoethyl)benzene-1,2-diol (dopamine) contains both amino and catechol moieties, each capable of a diversity of potential reactions and interactions. (justia.com)

Initially transcribed as a pro-enzyme, the catechol oxidase precursor undergoes two rounds of proteolytic processing and transport before it enters the thylakoid lumen. (wikipedia.org)
Based on analysis of the precursor and mature catechol oxidase purified from Ipomoea batatas, proteolytic processing removes both the N-terminal transit peptide as well as a C-terminal domain that covers the enzyme active site. (wikipedia.org)
Under the assay conditions used, E-4-H was the predominant catechol estrogen-forming monooxygenase enzyme. (biomedsearch.com)
The structural and spectroscopic characterization of mononuclear iron(III)-catecholato complexes of ligand L4 (methyl bis(1-methylimidazol-2-yl)(2-hydroxyphenyl)methyl ether, HL4) are described, which closely mimic the enzyme-substrate complex of the intradiol-cleaving catechol dioxygenases. (uu.nl)
Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. (ox.ac.uk)
Ito, M & Que, L 1997, ' Biomimetic Extradiol Cleavage of Catechols: Insights into the Enzyme Mechanism ', Angewandte Chemie (International Edition in English) , vol. 36, no. 12, pp. 1342-1344. (umn.edu)
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (wakehealth.edu)

It is, therefore, an object of this invention to provide an improved process for the oxidation of phenol to hydroquinone and catechol wherein the production of the undesired by product tar is suppressed leading thereby to enhanced yields of hydroquinone and catechol. (americans-world.org)
It has been found that when the process of conversion of phenol to a mixture of hydroquinone and catechol is carried out in accordance with the above mentioned features and embodiments of this invention, there is a significant reduction in the amount of by-product tar formation. (americans-world.org)
This invention relates to an improved process for the conversion of phenol to a mixture of hydroquinone and catechol. (americans-world.org)
Simultaneous Detection of Hydroquinone and Catechol Using Platinum Nanoparticles Decorated Graphene/Poly-Cyclodextrin/Multiwalled Carbon Nanotubes (MWCNTs) Nanocomposite Based Biosensor. (americanelements.com)
The simultaneous determination of hydroquinone (HQ) and catechol (CC) at PtNPs/Gr-CDP-MWCNTs/GCE is reported in the present work. (americanelements.com)
Due to the excellent catalytic activity, enhanced electrical conductivity, high surface area and porous structure of the RGO-MWNTs, the RGO-MWNTs/GCE achieved the simultaneous measurement of hydroquinone (HQ), catechol (CC), p-cresol (PC) and nitrite (NO 2 − ) with well-separate four peaks. (deepdyve.com)

Analysis of the product vibrational energy distribution also reveals that the O-H bond strength of the non hydrogen bonded O-H moiety in catechol , D 0 (H-catechoxyl) ≤ 27 480 ± 50 cm −1 , ∼2500 cm −1 lower than that of the sole O-H bond in bare phenol . (rsc.org)
In the current study, we measured the biodegradation rates of phenol and catechol, which are known pollutants, by one of the most active strains selected during our previous screening in clouds ( Rhodococcus enclensis ). (atmos-chem-phys-discuss.net)
For catechol, biodegradation transformation is about ten times faster than for phenol. (atmos-chem-phys-discuss.net)
The experimentally derived biodegradation rates are included in a multiphase box model to compare the chemical loss rates of phenol and catechol in both the gas and aqueous phases to their biodegradation rate in the aqueous phase under atmospheric conditions. (atmos-chem-phys-discuss.net)
Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens. (semanticscholar.org)

Catechol oxidase is a copper oxidase that contains a type 3 di-copper cofactor and catalyzes the oxidation of ortho-diphenols into ortho-quinones coupled with the reduction of molecular oxygen to water. (wikipedia.org)
In plants, catechol oxidase plays a key role in enzymatic browning by catalyzing the oxidation of catechol to o-quinone in the presence of oxygen, which can rapidly polymerize to form the melanin that grants damaged fruits their dark brown coloration. (wikipedia.org)
Polyphenol oxidases are a family of di-copper metalloenzymes that include tyrosinase and catechol oxidase. (wikipedia.org)
The key difference between the two related enzymes is that tyrosinase can catalyze the hydroxylation of monophenols to diphenols (monophenolase activity) as well as the oxidation of the o-diphenol to the o-quinone (diphenolase activity) whereas catechol oxidase only possesses diphenolase activity. (wikipedia.org)
When plant tissue is damaged, the chloroplast may rupture and release catechol oxidase into the plant cytoplasm, and vacuoles may also rupture, releasing stored catechol into the cytoplasm. (wikipedia.org)
Thus, tissue damage facilitates the interaction of catechol oxidase with its substrate to produce o-benzoquinone, which can polymerize non-enzymatically to yield melanins that form an insoluble barrier for wound protection. (wikipedia.org)
Catechol oxidase is nuclear-encoded, and its N-terminal end contains a signal peptide that directs the protein to the chloroplast thylakoid lumen, where it can either be soluble or loosely associated with the thylakoid membrane. (wikipedia.org)
The crystal structure of catechol oxidase purified from Ipomoea batatas has been resolved in its active form in both the oxidized Cu(II)-Cu(II) state and the reduced Cu(I)-Cu(I) state. (wikipedia.org)
While the active site of both tyrosinase and catechol oxidase contain the di-copper center, variations in each enzyme's respective structure result in differing activity. (wikipedia.org)
In catechol oxidase, a phenylalanine side-chain (Phe261) is above one of the copper centers and prevents the substrate from coordinating with both copper ions in the active site. (wikipedia.org)
This precludes the bidentate coordination complex necessary for di-phenolate hydroxylation characteristic of tyrosinase but absent in catechol oxidase. (wikipedia.org)
Although a crystal structure of catechol oxidase has been solved, questions concerning the exact mechanism of the reaction remain. (wikipedia.org)
Catechol Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "Catechol Oxidase" by people in this website by year, and whether "Catechol Oxidase" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Catechol Oxidase" by people in Profiles. (wakehealth.edu)

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. (elsevier.com)
Inhibition of catechol-O-methyltransferase by tolcapone has been shown to increase levodopa bioavailability and plasma elimination half life, thereby prolonging the efficacy of levodopa. (bmj.com)
Keränen T, Gordin A, Harjola V-P, Karlsson M, Korpela K, Pentikäinen PJ, Rita H, Seppälä L, Wikberg T (1993) The effect of catechol-O-methyltransferase inhibition by entacapone, on the pharmacokinetics and metabolism of levodopa in healthy volunteers. (springer.com)

Two regions involved in catechol biosynthesis (cbs) of Erwinia carotovora W3C105 were cloned by functional complementation of Escherichia coli mutants that were deficient in the biosynthesis of the catechol siderophore enterobactin (ent). (elsevier.com)
Although functions encoded by catechol biosynthesis genes (cbsA, cbsB, cbsC, cbsD, and cbsE) of E. carotovora were interchangeable with those encoded by corresponding enterobactin biosynthesis genes (entA, entB, entC, entD, and entE), only cbsE hybridized to its functional counterpart (entE) in E. coli. (elsevier.com)
Strains of E. carotovora fell into nine groups on the basis of sizes of restriction fragments that hybridized to the cbsEA region, indicating that catechol biosynthesis genes were highly polymorphic among strains of E. carotovora. (elsevier.com)

The level of catechol metabolism in the RVLM 1) is continuously related to the level of arterial CO2, 2) functions close to its resting level under baseline nonstimulated condition with respect to CO2, and 3) is reversibly modified on changes in capnia. (biomedsearch.com)
strain P51 tcb gene cluster, which encodes metabolism of chlorinated catechols: evidence for specialization of catechol 1,2-dioxygenases for chlorinated substrates. (asm.org)

Moreover, amongst a number of catechol derivatives tested 2 4-allylcatechol exhibited the maximum antioxidant activity. (erowid.org)
2. Term loosely used for catechin, which contains an o -catechol moiety, and as the root of catecholamines, which are pyrocatechol derivatives. (thefreedictionary.com)
Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes. (thefreedictionary.com)
Borgulya J, Bruderer H, Bernauer K, Zürcher G, Da Prada M (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives - synthesis and structure activity studies. (springer.com)

Copper(II)-induced oxidations of aromatic substrates: catalytic conversion of catechols to o-benzoquinones. (americans-world.org)
Specifically, membrane-bound catechol- O -methyltransferase (MBCOMT) is an integral membrane protein that catalyzes the methylation of catechol substrates and has been linked to several diseases such as Parkinson's disease and Schizophrenia. (biomedcentral.com)

I have been interested in preparing Benzene-1,2-diol (catechol) for some time. (sciencemadness.org)

Here, a supramolecular approach based on ureido-pyrimidinone (UPy) modified polymers is combined with catechol chemistry in order to achieve improved cellular adhesion onto supramolecular biomaterials. (rsc.org)
UPy-modified hydrophobic polymers with non-cell adhesive properties are developed that can be bioactivated via a modular approach using UPy-modified catechols. (rsc.org)
The results suggested that the promising way improved the phase adhesion of graft copolymers using catechol-functionalized polymers as versatile adhesive components. (mdpi.com)
In order to obtain dual-modal fluorescent magnetic nanoparticles, well-defined fluorescent functional polymers with terminal catechol groups were synthesized by single electron transfer living radical polymerization (SET-LRP) under aqueous conditions for "grafting to" modification of iron oxide nanoparticles. (monash.edu)
Haddleton, David M. / Synthesis of well-defined catechol polymers for surface functionalization of magnetic nanoparticles . (monash.edu)

Commonly, the molecular structure of flavonoids of high biological activity like quercetin or naringenin [4] includes a group derived from resorcinol and/or catechol [5,6]. (scielo.org.ar)

A significant relationship of equilibrium can be identified between the 2 and 16 hydroxy catechol metabolites. (thefreedictionary.com)
Diethylstilbestrol, a known transplacental testicular carcinogen in animals, seems to exert its effects in part through its catechol and/or reactive quinone metabolites ( 15 ). (aacrjournals.org)
Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. (aspetjournals.org)
Metabolites of entacapone [(E)-2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide++ +], a potent inhibitor of catechol-O-methyltransferase, were isolated from human and rat urine. (aspetjournals.org)

Polymorphisms in maternal or offspring genes encoding estrogen-metabolizing enzymes may influence prenatal catechol estrogen levels and could therefore be biomarkers of TGCC risk. (aacrjournals.org)

The autoxidation of nine catecholamines and two catechols as a function of pH was studied. (springer.com)
Enzymatic O -methylation of catechols and catecholamines. (springer.com)
Ionization constants of catechols and catecholamines. (springer.com)

Structure of catechol. (hindawi.com)
The aim of the study was to purify, characterize and predict template-based three-dimensional structure of catechol 1,2-dioxygenase (C12O) from indigenous Pseudomonas chlororaphis strain UFB2 ( Pc UFB2). (preprints.org)

Compared to bare carbon paste electrode (BCPE), the poly(niacinamide) MCPE shows good electrocatalytic activity towards the oxidation of catechol in phosphate buffer solution (PBS) of physiological pH 7.4. (hindawi.com)
The micelles with higher catechol content formed stable spherical micelles and showed increased stability against auto-oxidation, while micellization did not affect the redox potential of catechol moieties. (elsevier.com)

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. (justia.com)
To facilitate the synthesis of DOPA-containing therapeutic compounds and biomimetic materials, it is necessary to properly protect the catechol side-chain of DOPA during chemical reactions. (justia.com)

Then, the modified MMT was coated onto a surface using the reaming catechol moiety [15, 16]. (thefreedictionary.com)
Part 1: The importance of the catechol moiety and aspects of the B-ring structure. (lu.se)
This part concerns the catechol moiety of the A-ring as well as the 2,3,4,5-tetrahydro-1H-2-azepine moiety (the B-ring) of capsazepine. (lu.se)

Catechol dioxygenases in microorganisms cleave catechol into cis - cis -muconic acid or 2-hydroxymuconic semialdehyde via the ortho- or meta- pathway, respectively. (preprints.org)

Flohe L, Schwabe K-P. Kinetics of purified catechol- O -methyltransferase. (springer.com)
Kinetics and Mechanism of Birnessite Reduction by Catechol" by Christopher J. Matocha, Donald L. Sparks et al. (unl.edu)
The complex interactions of oxidizable organic ligands with soil Mn(III,IV) (hydr)oxide minerals have received little study by in situspectroscopic techniques.We used a combination of an in situ electron paramagnetic resonance stopped-flow (EPR-SF) spectroscopic technique and stirred-batch studies to measure the reductive dissolution kinetics of birnessite (δ-MnO 2 ), a common Mn mineral in soils, by catechol (1,2-dihydroxybenzene). (unl.edu)

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (hmdb.ca)

Powder X-ray diffraction (XRD), X-ray photoelectron spectrum analysis (XPS), Fourier transform infrared spectra, thermogravimetric analysis, and UV-Vis diffuse reflectance spectra were carried out to characterize the composites with different catechol contents and different preparation temperatures. (deepdyve.com)
The micelles were prepared from a hydrophilic poly(N-acryloyl morpholine) and a hydrophobic catechol-bearing block with different catechol content. (elsevier.com)

Bio-inspired from the strong adhesion ability of mussel proteins, renewable and robust soy-based composite films were fabricated from two soybean-derived industrial materials: soluble soybean polysaccharide (SSPS) and catechol-functionalized soy protein isolate (SPI-CH). The conjugation of SPI with multiple catechol moieties as a versatile adhesive component for SSPS matrix efficiently improved the interfacial adhesion between each segment of biopolymer. (mdpi.com)

This thesis describes novel catechol-functionalized multidentate block copolymer (Cat-MDBC) strategy that enables the stabilization of SNPs with diameter ≤3.5 nm as effective MR bright imaging (T1-weighted) contrast agents. (concordia.ca)

To reach that goal, synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules with high yields. (csic.es)
In this study, we describe a bioinspired approach for preparing bioadhesive and biocompatible materials based on synthetic low molecular weight copolymers of a flexible catechol-functionalized methacrylate (CEMA) and N -vinylcaprolactam. (csic.es)

Cloning and expression of Acinetobacter calcoaceticus catechol 1,2-dioxygenase structural gene catA in Escherichia coli. (asm.org)

A polymeric thin film modified electrode, that is, poly(niacinamide) modified carbon paste electrode (MCPE), was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. (hindawi.com)
Karlsson M, Wikberg T (1992) Liquid chromatographic determination of a new catechol-O-methyltransferase inhibitor, entacapone, and its Z-isomer in human plasma and urine. (springer.com)

This natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels providing also the functionalized polymer with bioadhesion in the moist environment of the human body. (csic.es)

This article reports the striking interplay between the molecular structure and the photodissociation dynamics of catechol (a key dihydroxybenzene ), identified using a combination of electronic spectroscopy , hydrogen (Rydberg) atom photofragment translational spectroscopy , density functional theory and second order approximate coupled cluster methods. (rsc.org)

The nitro group of entacapone seems to hinder methylation of the catechol hydroxyls in man, because no methylation products were detected. (aspetjournals.org)

Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study. (painresearchforum.org)

Catechol (CC), that is also known as pyrocatechol or 1,2-dihydroxybenzene, is a simple organic compound as shown in Scheme 1 . (hindawi.com)

Catechol estrogen formation in the mouse uterus and its role in implantation. (biomedsearch.com)
We conducted a population-based, case-parent triad study ( 16 ) to test whether TGCC risk is related to maternal and/or offspring variation in genes involved in catechol estrogen formation ( CYP1A2, CYP1B1, CYP3A4 , and CYP3A5 ). (aacrjournals.org)

During daytime, biodegradation of catechol is even predicted to exceed the chemical activity in the aqueous phase and to represent a significant sink (17 %) of total catechol in the atmospheric multiphase system. (atmos-chem-phys-discuss.net)
3-(2-Hydroxyphenoxy)phthalide is an intermediate in the hydrolysis of OO-(2-carboxybenzylidene) catechol in aqueous buffers of pH 2·9-5. (hud.ac.uk)

The biomimetic adherent catechol moieties were successfully bonded in the polymeric network based on catechol crosslinking chemistry through simple oxidative coupling and/or coordinative interaction. (mdpi.com)

The purification and properties of pig-liver catechol- O -methyltransferase. (springer.com)
Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. (nih.gov)
Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? (elsevier.com)
1992). Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1--q11.2. (salimetrics.com)
No difference in the distribution of the catechol-O-methyltransferase genotypes (H/H, H/L, L/L) and alleles (H, L) was observed between the patients and the controls. (ovid.com)
In addition, significant differences in the frequencies of the catechol-O-methyltransferase allele (χ2=4.481, df=1, P=0.040) were observed between the non-violent group and the controls. (ovid.com)
Catechol-O-methyltransferase: a dual-role player in different breast cancer subtypes? (muni.cz)
Ball P, Knuppen R, Breuer H (1971) Purification and properties of catechol-O-methyltransferase of human liver. (springer.com)
Guldberg HC, Marsden CA (1975) Catechol-O-methyltransferase: Pharmacological aspects and physiological role. (springer.com)
Belongs to the mammalian catechol-O-methyltransferase family. (mybiosource.com)

The purpose of this study was purification and characterization of catechol 1,2-dioxygenase from Geobacillus sp. (semanticscholar.org)

Based on our results, we propose a new explanation for binding synergy between catechols and cations based on the relationship between solution conditions, bond lifetimes, and competitive binding of adhesive moieties to mica surfaces. (aiche.org)
We recently reported antioxidant micelles having catechol moieties, a structural motif found among natural antioxidants. (elsevier.com)

8 The strong adhesive properties of these threads originate from catechol residues of DOPA, which have efficient and versatile cross-linking abilities. (rsc.org)
Various protecting groups have been reported to protect the side-chain catechol group of DOPA residues, including cyclic ethyl orthoformate, 11 TBDPS, 12 and acetonide. (justia.com)

In reducing conditions, catechol residues can undergo various interactions, such as hydrogen bonding, electrostatic interactions or metal-catechol coordination. (rsc.org)
9 Once exposed to oxygen, catechol residues are oxidized to reactive o -quinones. (rsc.org)
conjugated catechol residues to the backbone of alginate, to develop biocompatible 3D hydrogel for cell transplantation. (rsc.org)

To do so, catechol chemistry is often used to introduce adhesiveness into biomaterials. (rsc.org)

It can safely be presumed that a part of the rearrangement proceeds counter-clockwise by the ortho mechanism as for catechol monoallyl ether, thereby yielding the expected 3-allylcatechol ( VIII ). (erowid.org)

Organisms9

Chemicals and Drugs37

Phenomena and Processes4

Health Care1

Action of 3 tyrphostin derivatives on casein kinase II from rat liver. (1/1002)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/1002)

Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (3/1002)

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. (4/1002)

Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats. (5/1002)

Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. (6/1002)

Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (7/1002)

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. (8/1002)

Catechols

Catechol 2,3-Dioxygenase

Estrogens, Catechol

Catechol 1,2-Dioxygenase

Catechol O-Methyltransferase

Dioxygenases

Oxygenases

Catechol Oxidase

Phenol

Hydroxybenzoates

Sorbic Acid

Equilenin

Pseudomonas

Benzoates

Biodegradation, Environmental

Pseudomonas putida

Benzene

Pyrogallol

Phenols

Benzoic Acid

Adipates

Chlorobenzenes

Cresols

Hydroxyestrones

Toluene

Hydroquinones

Chlorobenzoates

Planococcus Bacteria

Acinetobacter

Alcaligenes

Rhodococcus

Mixed Function Oxygenases

Siderophores

Quinones

Monophenol Monooxygenase

Pseudomonas mendocina

Oxidation-Reduction

Toluidines

Adrenochrome

Gentisates

Salicylates

Benzophenones

Normetanephrine

Ralstonia

Hydroxylation

Catecholamines

Xylenes

Gram-Negative Aerobic Rods and Cocci

Substrate Specificity

Parabens

Genes, Bacterial

Action of 3 tyrphostin derivatives on casein kinase II from rat liver. (1/1002)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/1002)

Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (3/1002)

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. (4/1002)

Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats. (5/1002)

Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. (6/1002)

Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (7/1002)

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. (8/1002)

Unscramble pyrocatechol | Words unscrambled from letters pyrocatechol | Scrabble Word pyrocatechol | Words Made with the...

Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis...

Kinetics and Mechanism of Birnessite Reduction by Catechol by Christopher J. Matocha, Donald L. Sparks et al.

Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in...

BRENZKATECHINVIOLETT (pyrocatechol violet): Topics by WorldWideScience.org

Team:Lethbridge/Project - 2011.igem.org

Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical Journal

One Mystery Of How Mussels Stick To Rocks, Boats Solved

Team:Toronto/Results - 2010.igem.org

Team:Toronto/Results - 2010.igem.org

Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org

The gene cluster, coding for the chlorocatechol sp. of hereditary, biochemical, - The proteasome: structure, function, and role...

Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org

In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates | 10.1007/s11164...

Comtan (Entacapone): Side Effects, Interactions, Warning, Dosage & Uses

dcyphr | Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease

TCI AMERICAS 4-Nitrocatechol,5g - 20EM61|N0273-5G - Grainger

TCI AMERICAS 4-Chlorocatechol,25g - 29LF61|C0568-25G - Grainger

Catechol, 99+%, ACROS Organics™ | Fisher Scientific

KAKEN - Researchers | NOZAKI Mitsuhiro (00025545)

Entacapone Teva - information til sundhedsfaglige - Medicin.dk