Catechol 2,3-Dioxygenase
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
Estrogens, Catechol
Catechol 1,2-Dioxygenase
Catechol O-Methyltransferase
Dioxygenases
Oxygenases
Catechol Oxidase
Hydroxybenzoates
Equilenin
Pseudomonas
Benzoates
Biodegradation, Environmental
Pseudomonas putida
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Benzoic Acid
Adipates
Hydroxyestrones
Planococcus Bacteria
Acinetobacter
Alcaligenes
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Siderophores
Quinones
Monophenol Monooxygenase
Pseudomonas mendocina
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Salicylates
Normetanephrine
Ralstonia
Hydroxylation
Xylenes
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Gram-Negative Aerobic Rods and Cocci
A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.
Substrate Specificity
Parabens
Action of 3 tyrphostin derivatives on casein kinase II from rat liver. (1/1002)
AIM: To study the action of tyrphostin on casein kinase (CK) II. METHODS: CK II was partially purified from rat livers by sequential DE52 and heparin-Sepharose chromatography. CK II activity was assayed by incubating CK II with dephosphorylated casein and [gamma-32P]ATP. RESULTS: AG34 inhibited the activity of CK II with IC50 33 (27-41) mumol.L-1. Both AG372 (121 mumol.L-1) and AG1112 (150 mumol.L-1) displayed inhibitory effects on the activity of CK II. Kinetic studies of AG34 on CK II showed that it was noncompetitive with casein and ATP. CONCLUSION: AG34, AG372, and AG1112 were potent inhibitors of CK II, and the inhibitory action of AG34 was noncompetitive with casein and ATP. (+info)Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/1002)
The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity. (+info)Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (3/1002)
We identified and characterized a methyl transfer activity of the toluate cis-dihydrodiol (4-methyl-3,5-cyclohexadiene-cis-1, 2-diol-1-carboxylic acid) dehydrogenase of the TOL plasmid pWW0 towards toluene cis-dihydrodiol (3-methyl-4,5-cyclohexadiene-cis-1, 2-diol). When the purified enzyme from the recombinant Escherichia coli containing the xylL gene was incubated with toluene cis-dihydrodiol in the presence of NAD+, the end products differed depending on the presence of adenosylcobalamin (coenzyme B12). The enzyme yielded catechol in the presence of adenosylcobalamin, while it gave 3-methylcatechol in the absence of the cofactor. Adenosylcobalamin was transformed to methylcobalamin as a result of the enzyme reaction, which indicates that the methyl group of the substrate was transferred to adenosylcobalamin. Other derivatives of the cobalamin such as aquo (hydroxy)- and cyanocobalamin did not mediate the methyl transfer reaction. The dehydrogenation and methyl transfer reactions were assumed to occur concomitantly, and the methyl transfer reaction seemed to depend on the dehydrogenation. To our knowledge, the enzyme is the first dehydrogenase that shows a methyl transfer activity as well. (+info)Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. (4/1002)
Earlier study suggested that 3,4-dihydroxytamoxifen (tam catechol), a tamoxifen metabolite, is proximate to the reactive intermediate that binds covalently to proteins and possibly to DNA (). The current study demonstrates that rat and human hepatic cytochrome P-450s (CYPs) catalyze tam catechol formation from tamoxifen (tam), 3-hydroxy-tam (Droloxifene), and 4-hydroxy-tam (4-OH-tam). Higher levels of catechol were formed from 4-OH-tam and 3-hydroxy-tam than from tam. Evidence that human hepatic CYP3A4 and 2D6 catalyze the formation of tam catechol from 4-OH-tam and supportive data that the catechol is proximate to the reactive intermediate, was obtained: 1) There was a good correlation (r = 0.82; p +info)Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats. (5/1002)
AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2. Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of 63Ni was shown by the whole-body autoradiography. RESULTS: CBMIDA s.c. 0.5-1.5 g.kg-1 markedly reduced the mortality from acute poisoning of i.p. NiCl2 500 mg.kg-1. After i.p. NiCl2 in mice, the LD50 was 82.7 mg.kg-1. Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively. The LD50 of NiCl2 was 39 mg.kg-1 in rat. If CBMIDA was injected i.m. 0.5 g.kg-1 after i.p. NiCl2, the LD50 was 332 mg.kg-1. CBMIDA 1.5 g.kg-1 i.m. after i.v. 63NiCl2, decreased the contents of 63Ni in blood and lung of mice vs control mice at 24 h. The contents of 63Ni in brain, heart, spleen, and kidney were similar to those of the control mice. The content of 63Ni in bone was more than the control. The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiography showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of 63Ni in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. There was a marked reduction of 63Ni in the lung, skin, liver, and blood after i.p. CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice and rats, and decreased 63Ni levels in lung and blood. (+info)Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. (6/1002)
Two Escherichia coli transformants with catechol 1,2-dioxygenase activity were selected from a gene library of the benzamide-assimilating bacterium Arthrobacter species strain BA-5-17, which produces four catechol 1,2-dioxygenase isozymes. A DNA fragment isolated from one transformant contained a complete open reading frame (ORF). The deduced amino acid sequence of the ORF shared high identity with hydroxyquinol 1,2-dioxygenase. An enzyme expressed by the ORF was purified to homogeneity and characterized. When hydroxyquinol was used as a substrate, the purified enzyme showed 6.8-fold activity of that for catechol. On the basis of the sequence identity and substrate specificity of the enzyme, we concluded that the ORF encoded hydroxyquinol 1,2-dioxygenase. When catechol was used as a substrate, cis,cis-muconic acid and 2-hydroxymuconic 6-semialdehyde, which were products by the intradiol and extradiol ring cleavage activities, respectively, were produced. These results showed that the hydroxyquinol 1,2-dioxygenase reported here was a novel dioxygenase that catalyzed both the intradiol and extradiol cleavage of catechol. (+info)Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (7/1002)
The inotropic/lusitropic effects of beta-adrenergic agonists on the heart are mediated largely by protein kinase A (PKA)-catalyzed phosphorylation of phospholamban, the natural protein regulator of the Ca2+ pump present in sarcoplasmic reticulum (SR) membranes. Gingerol, a plant derivative, is known to produce similar effects when tested in isolated cardiac muscle. The purpose of the present study was to compare the effects of gingerol and another plant derivative, ellagic acid, on the kinetics of the SR Ca2+ pump with those of PKA-catalyzed phospholamban phosphorylation to elucidate their mechanisms of Ca2+ pump regulation. As previously demonstrated for PKA, 50 microM gingerol or ellagic acid increased Vmax(Ca) of Ca2+ uptake and Ca2+-ATPase activity assayed at millimolar ATP concentrations in light cardiac SR vesicles. Unlike PKA, which decreases Km(Ca), neither compound had a significant effect on Km(Ca) in unphosphorylated vesicles. However, gingerol increased Km(Ca) in phosphorylated vesicles, in which Ca2+ uptake was significantly increased further at saturating Ca2+ and remained unchanged at subsaturating Ca2+. An inhibition of Ca2+ uptake by gingerol at micromolar MgATP concentrations was overcome with increasing MgATP concentrations. The stimulation of Ca2+ uptake attributable to gingerol in unphosphorylated microsomes at saturating Ca2+ was 30% to 40% when assayed at 0.05 to 2 mM MgATP and only about 12% in phosphorylated microsomes as well as in rabbit fast skeletal muscle light SR. The present results support the view that an ATP-dependent increase in Vmax(Ca) of the SR Ca2+ pump plays an important role in mediating cardiac contractile responses to gingerol and phospholamban-dependent beta-adrenergic stimulation. (+info)A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. (8/1002)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. A polymorphism in NQO1, a C609T substitution, has been identified, and individuals homozygous for this change (T/T) have no detectable NQO1. Exposed workers with a T/T genotype have an increased risk of benzene hematotoxicity. This finding suggests NQO1 is protective against benzene toxicity, which is difficult to reconcile with the lack of detectable NQO1 in human bone marrow. The human promyeloblastic cell line, KG-1a, was used to investigate the ability of the benzene metabolite hydroquinone (HQ) to induce NQO1. A concentration-dependent induction of NQO1 protein and activity was observed in KG-1a cells cultured with HQ. Multiple detoxification systems, including NQO1 and glutathione protect against benzene metabolite-induced toxicity. Indeed, exposure to a noncytotoxic concentration of HQ induced both NQO1 and soluble thiols and protected against HQ-induced apoptosis. NQO1 protein and activity increased in wild-type human bone marrow cells (C/C) exposed to HQ, whereas no NQO1 was induced by HQ in bone marrow cells with the T/T genotype. Intermediate induction of NQO1 by HQ was observed in heterozygous bone marrow cells (C/T). NQO1 also was induced by HQ in wild-type (C/C) human bone marrow CD34(+) progenitor cells. Our data suggest that failure to induce functional NQO1 may contribute to the increased risk of benzene poisoning in individuals homozygous for the NQO1 C609T substitution (T/T). (+info)
Unscramble pyrocatechol | Words unscrambled from letters pyrocatechol | Scrabble Word pyrocatechol | Words Made with the...
Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis...
Kinetics and Mechanism of Birnessite Reduction by Catechol by Christopher J. Matocha, Donald L. Sparks et al.
Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in...
BRENZKATECHINVIOLETT (pyrocatechol violet): Topics by WorldWideScience.org
Team:Lethbridge/Project - 2011.igem.org
Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical Journal
One Mystery Of How Mussels Stick To Rocks, Boats Solved
Team:Toronto/Results - 2010.igem.org
Team:Toronto/Results - 2010.igem.org
Bis(O-(N-benzyl-N-(1,1-dimethylethoxy)carbonyl-ethylamine)) Catechol | CAS: 1391054-05-9 | Bis(O-(N-benzyl-N-(1,1...
Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org
The gene cluster, coding for the chlorocatechol sp. of hereditary, biochemical, - The proteasome: structure, function, and role...
Catechol boronate formation and its electrochemical oxidation - Chemical Communications (RSC Publishing)
Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org
In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates | 10.1007/s11164...
229. Does labetolol provide sufficient alpha blockade to use in high catechol states? / Dose and use of esmolol /...
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Comtan (Entacapone): Side Effects, Interactions, Warning, Dosage & Uses
mhpE - 4-hydroxy-2-oxovalerate aldolase - Escherichia coli (strain K12) - mhpE gene & protein
dcyphr | Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease
TCI AMERICAS 4-Nitrocatechol,5g - 20EM61|N0273-5G - Grainger
TCI AMERICAS 4-Chlorocatechol,25g - 29LF61|C0568-25G - Grainger
Catechol, 99+%, ACROS Organics™
| Fisher Scientific
Catechol (C6H6O2) | RMI
KAKEN - Researchers | NOZAKI Mitsuhiro (00025545)
Entacapone Teva - information til sundhedsfaglige - Medicin.dk
L-DOPA biotransformation: Correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with...
Plus it
Catechol | definition of catechol by Medical dictionary
Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons...
EC 1.13.11.2
Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog
Plus it
IJMS | Free Full-Text | Relation Between the Adsorbed Quantity and the Immersion Enthalpy in Catechol Aqueous Solutions on...
New Cures » cancer curing ginger
ACPD - Biodegradation of phenol and catechol in cloud water: Comparison to chemical oxidation in the atmospheric multiphase...
IJMS | Free Full-Text | The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites
인간진피섬유아세포에서 6-Shogaol의 세포보호 및 항염증 효과
Entacapone Tablets, USP*
What Is Pharmacology - Entacapone - Medicalrealm
OSA | Quantitative Analysis of Entacapone Isomers Using Surface-Enhanced Raman
Spectroscopy and Partial Least...
DNA degradation by the mixture of copper and catechol is caused by DNA-copper-hydroperoxo complexes, probably DNA-Cu(I)OOH |...
Metabolism of [6]-Shogaol in Mice and in Cancer Cells | Drug Metabolism & Disposition
A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder...
o- catechol methyltransferase inhibitors and their use in the treatment of psychiatric disorders | Semantic Scholar
6]-Gingerol >= 98 % HPLC | 23513-14-6 | Sigma...
Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA - Fingerprint - UC Davis
butyl carbitol sds
Catechol ring-cleavage inPseudomonas cepacia: the simultaneous induction oforthoandmetapathways | SpringerLink
Non‐Carbohydrate Glycomimetics as Inhibitors of Calcium(II)‐binding Lectins - Centre de recherches sur les macromolécules...
Catechol changes in the rat rostral ventrolateral medulla following changes in systemic CO2.
Carbolic acid-Phenol | Henriettes Herbal Homepage
Complexation of Zn(II) by catechol in hydroxylic solvents
US 8492367 B2 - Use Of 2,5-dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea -
The Lens
US 2013/0296282 A1 - Methods Of Use For 2,5-dihydroxybenzene Sulfonic Acid Compounds For The Treatment Of Cancer, Rosacea And...
Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric...
Effects of hispolon on glioblastoma cell growth. - PubMed - NCBI
KEGG Metagenome: T31030
strain RP007-rif Strain Passport - StrainInfo
Inhibition of soluble catechol- O -methyltransferase and single-dose pharmacokinetics after oral and intravenous administration...
GMD - 2OXOVALERATE, TBS 1X, METHOXIM 2
GMD - 2OXOVALERATE, TBS 2X (ENOL2)
Decarboxylation of 2,3-dihydroxybenzoate to catechol supports growth of fermenting bacteria
ETIS - Grouping of phenol hydroxylase and catechol 2,3-dioxygenase genes among phenol- and p-cresol-degrading Pseudomonas...
JoVE Search Results: Catechol 1%2C2 Dioxygenase
Reverse-phase chromatography of polar biological substances: separation of catechol compounds by high-performance liquid...
Bioactive flavonoids and catechols as Hif1 and Nrf2 protein stabilizers - implications for Parkinsons disease - Fingerprint ...
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Dynamic experimental methods using in-situ measurements of the surface intermediates applied to the fine chemistry - Infoscience
Search Results
Gingerol | GreenMedInfo | Substance | Natural Medicine | Alternative
6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion...
4-Shogaol | GreenMedInfo | Substance | Natural Medicine | Alternative
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Catechol
... catechol was listed as pyrocatechol. In 1879, the Journal of the Chemical Society recommended that catechol be called "catechol ... Catechol occurs as feathery white crystals that are very rapidly soluble in water. Catechol was first isolated in 1839 by Edgar ... Iron-containing dioxygenase enzymes catalyze the cleavage of catechol. Catechols convert to the semiquinone radical. At pH = 7 ... Catechol has since been shown to occur in free form naturally in kino and in beechwood tar. Its sulfonic acid has been detected ...
Catechol estrogen
A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in ... Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and ...
Catechol oxidase
In plants, catechol oxidase plays a key role in enzymatic browning by catalyzing the oxidation of catechol to o-quinone in the ... As catechol enters the active site, a proton is abstracted from one of the alcohols. The catechol coordinates with a Cu(II) ... The coordinated hydroxide ion abstracts another proton from catechol to form water, and the catechol is oxidized to o-quinone. ... In this state, the enzyme active site is in a ternary catechol oxidase-O22−-catechol complex. Two electrons are transferred ...
Catechol dioxygenase
... s are metalloprotein enzymes that carry out the oxidative cleavage of catechols. This class of enzymes ... An example of the reaction carried out by catechol 1,2-dioxygenase is the formation of cis,cis-muconic acid from catechol, ... catechol 2,3-dioxygenase (EC 1.13.11.2), and protocatechuate 3,4-dioxygenase (EC 1.13.11.3). The active site of catechol ... The Pseudomonas putida xylE gene, which encodes catechol 2,3-dioxygenase, is often used as a reporter to quantitate gene ...
Catechol oxidase (dimerizing)
In enzymology, a catechol oxidase (dimerizing) (EC 1.1.3.14) is an enzyme that catalyzes the chemical reaction 4 catechol + 3 ... The systematic name of this enzyme class is catechol:oxygen oxidoreductase (dimerizing). Nair PM, Vining LC (July 1964). " ... the two substrates of this enzyme are catechol and O2, whereas its two products are [[dibenzo[1,4]dioxin-2,3-dione]] and H2O. ... "Enzymic oxidation of catechol to diphenylenedioxide-2,3-quinone". Archives of Biochemistry and Biophysics. 106: 422-7. doi: ...
Chloridazon-catechol dioxygenase
... (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-(2,3- ... Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986". Eur. J. Biochem. 125 (3): 579-84. doi:10.1111/j. ... Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl ...
Catechol-O-methyltransferase
Wikimedia Commons has media related to Catechol O-methyltransferase, COMT. Catechol+O-Methyltransferase at the US National ... and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the ... Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. ... December 2008). "The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life". ...
Catechol-O-methyltransferase inhibitor
A catechol-O-methyltransferase (COMT) inhibitor is a drug that inhibits the enzyme catechol-O-methyltransferase. This enzyme ... Catechol-O-methyltransferase inhibitors, All stub articles, Nervous system drug stubs). ... "Identification of novel flavonoid inhibitor of Catechol-O-Methyltransferase enzyme by molecular screening, quantum mechanics/ ... diarrhea drowsiness urine discoloration dyskinesia Medication Management of Parkinson's disease catechol-O-methyltransferase ...
Catechol 1,2-dioxygenase
Catechol 1,2- dioxygenase (EC 1.13.11.1, 1,2-CTD, catechol-oxygen 1,2-oxidoreductase, 1,2-pyrocatechase, catechase, catechol 1, ... Pascal RA, Huang DS (July 1986). "Reactions of 3-ethylcatechol and 3-(methylthio)catechol with catechol dioxygenases". Archives ... 2-dioxygenase and catechol 2,3-dioxygenase (2,3-CTD). The two enzymes were identified to be a part of two separate catechol ... a family of catechol dioxygenases that cleaves the bond between the phenolic hydroxyl groups of catechol using an Fe3+ cofactor ...
Catechol 2,3-dioxygenase
... (EC 1.13.11.2, 2,3-pyrocatechase, catechol 2,3-oxygenase, catechol oxygenase, metapyrocatechase, ... Catechol+2,3-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: long ... Kojima Y, Itada N, Hayaishi O (August 1961). "Metapyrocatachase: a new catechol-cleaving enzyme". The Journal of Biological ... pyrocatechol 2,3-dioxygenase) is an enzyme with systematic name catechol:oxygen 2,3-oxidoreductase (decyclizing). This enzyme ...
Piperonal
... can be prepared by the oxidative cleavage of isosafrole or by using a multistep sequence from catechol or 1,2- ... Synthesis from catechol requires an additional step, Williamson ether synthesis using dichloromethane. Piperonal, like all ... doi:10.1016/S0040-4039(00)88578-0. Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the ...
1,3-Benzodioxole
doi:10.2174/1389200003339270 Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the Chemical ... 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes. 1,4-Benzodioxine MDMA Methylenedioxy Safrole ...
Dakin oxidation
Catechol, for example, is synthesized from o-hydroxy and o-alkoxy phenyl aldehydes and ketones, and is used as the starting ... Bora, Porag; Bora, Bondana; Bora, Utpal (2021). "Recent developments in synthesis of catechols by Dakin oxidation". New Journal ... Dakin, H.D. (1923). "Catechol". Organic Syntheses. 3: 28. doi:10.15227/orgsyn.003.0028. Surrey, Alexander R. (1946). " ...
Salicylaldehyde
Dakin, H. D. (1923). "Catechol" (PDF). Organic Syntheses. 3: 28.; Collective Volume, vol. 1, p. 149 Burgstahler, A. W.; Worden ... Salicylaldehyde is used to make the following: Oxidation with hydrogen peroxide gives catechol (1,2-dihydroxybenzene) (Dakin ...
2-Hydroxyestrone
... (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol ... Okatani Y, Fishman J (July 1986). "Inhibition of the preovulatory prolactin surge in the rat by catechol estrogens: functional ... 2-OHE1 is the most abundant catechol estrogen in the body. 2-Hydroxyestrone is not significantly uterotrophic in bioassays, ... When incubated at very high concentrations or in combination with a catechol O-methyltransferase (COMT) inhibitor to prevent ...
History of catecholamine research
In the case the catecholamines, however, the enzymes of degradation monoamine oxidase and catechol-O-methyl transferase, like ... In this respect, ″amino-ethanol-catechol″ - noradrenaline - mimicked sympathetic nerves more closely than adrenaline did. The ... Julius Axelrod (1962). "O-Methylation of epinephrine and other catechols". Science. 126 (3270): 400-401. doi:10.1126/science. ... noradrenaline and adrenaline were O-methylated by catechol-O-methyl transferase. To fill the gap completely, however, the role ...
Methyltransferase
Catechol-O-methyltransferase (COMT) degrades a class of molecules known as catcholamines that includes dopamine, epinephrine, ... "COMT catechol-O-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. Ragsdale, S.W. "Catalysis of ... Examples include: Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate- ...
Benzoate degradation via hydroxylation
Aerobic degradation forms catechol. Anaerobic degradation forms cyclohex-1,5-diene-1-carbonylCoA. A hybrid degradation forms ...
Siderocalin
... allowing siderocalin to bind to the iron-catechol complex. Catechols can be bound by siderocalin, in the form of free ligands, ... Mammalian siderophores, specifically catechols, can be found in the human gut and in siderophores, such as enterobactin, and ... Catechol resembling molecules can act as iron ligands in the cell and in systematic circulation, ... Rogers HJ (Mar 1973). "Iron-Binding Catechols and Virulence in Escherichia coli". Infection and Immunity. 7 (3): 445-56. doi: ...
Propoxur
It is produced from catechol. Several U.S. states have petitioned the Environmental Protection Agency (EPA) to use propoxur ... Catechol ethers, Isopropyl compounds, Aromatic carbamates, Phenol esters). ...
Siderophore
... the catechol-type siderophores, agrobactin; and the mixed ligand catechol-hydroxamate-hydroxy acid siderophores biosynthesized ...
Polyphenol oxidase
... catechol oxidases). The substrate preference of tyrosinases and catechol oxidases is controlled by the amino acids around the ... A mixture of monophenol oxidase and catechol oxidase enzymes is present in nearly all plant tissues, and can also be found in ... A monomeric catechol oxidase from Populus nigra converts caffeic acid to quinone and melanine at injured cells. ... Panis F, Kampatsikas I, Bijelic A, Rompel A (February 2020). "Conversion of walnut tyrosinase into a catechol oxidase by site ...
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Kobayashi S, Hayaishi O (1970). "Anthranilic acid conversion to catechol (Pseudomonas)". Methods Enzymol. 17A: 505-510. doi: ... catechol + CO2 + NAD(P)+ + NH3 The 5 substrates of this enzyme are anthranilate, NADH, NADPH, H+, and O2, whereas its 5 ... "Enzymatic formation of catechol from anthranilic acid". J. Biol. Chem. 239: 2204-2211. PMID 14209949. Portal: Biology v t e ( ... products are catechol, CO2, NAD+, NADP+, and NH3. This enzyme belongs to the family of oxidoreductases, specifically those ...
Muconolactone Δ-isomerase
Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes ... Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A ... of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. PMID 5330966. ...
Muconate lactonizing enzyme
... catechol branch and 2) protocatechuate branch. Catechol branch consists of cis, cis- muconate lactonizing enzyme, whereas a ... 3. Enzymes of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. doi:10.1016/S0021-9258(18)99841-8. ... Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. ... Ornston, L.N. (1970). Conversion of catechol and protocatechuate to β-ketoadipate (Pseudomonas putida). Methods Enzymol. ...
3-O-Methyldopa
... is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for ... 3-O-methyldopa is a major metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) and is formed by catechol-O-methyltransferase ( ... This process is catalyzed by catechol O-methyltransferase methylates (COMT). The action of the enzyme makes it possible the ... Tai, C. H.; Wu, R. M. (2002). "Catechol-O-methyltransferase and Parkinson's disease". Acta Medica Okayama. 56 (1): 1-6. PMID ...
Fjodor Lishajko
Euler, U. S. V.; Lishajko, F. (1959). "The Estimation of Catechol Amines in Urine". Acta Physiologica Scandinavica. 45 (2-3): ... Euler, U. S. Von; Lishajko, F. (1959). "Excretion of Catechol in Human Urine". Nature. 183 (4668): 1123-1123. doi:10.1038/ ...
4-carboxymuconolactone decarboxylase
Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes ... Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A ... of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. PMID 5330966. ...
Sclerotization
... which convert the catechol groups to quinones. The resulting quinones are susceptible to nucleophilic attack by amines and ... "Oxidative Conjugation of Catechols with Proteins in Insect Skeletal Systems". Tetrahedron. 57 (2): 385-392. doi:10.1016/S0040- ...
Rhododendrol
These phenols and catechols together form ortho-quinones (o-quinones). Presence of o-quinones can lead to cytotoxicity via the ... First, RD is catalysed by tyrosinase to produce toxic metabolites as RD-cyclic catechol. These reactive metabolites cause ... After oxidation of rhododendrol by the tyrosinase enzyme, several kinds of phenols and catechols are formed. ...
CDC - NIOSH Pocket Guide to Chemical Hazards -
Catechol
Browsing by Subject "Catechols"
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
... have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O- ... Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase ... The full functional implications of pharmacogenetic variation in the activities of catechol O-methyltransferase and histamine N ... have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O- ...
Catechol O-methyltransferase (chicken) | Protein Target - PubChem
Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify
Sciencemadness Discussion Board - Catechol preparation - Powered by XMB 1.9.11
Catechol preparation. I have been interested in preparing Benzene-1,2-diol (catechol) for some time. Heres the route of ... Phenol -, Salicylaldehyde - , Catechol. Maybe someone could post the full paper. One-pot synthesis of substituted catechols ... attack a condenser to the flask, and heat to 240°C(bp of catechol) and keep on this temperature until no more catechol is ... Catechol (pyrocatechol). Organic Syntheses, Coll. Vol. 1, p.149 (1941); Vol. 3, p.28 (1923).. To a solution of 122 g. (1 mole) ...
Catechol O-Methyltransferase
Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk1 | Cancer Epidemiology, Biomarkers & Prevention | American...
Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk1 Katja Mitrunen; Katja Mitrunen ... Millikan R. C., Pittman G. S., Tse C. K. J., Duell E., Newman B., Savitz D., Moorman P. G., Boissy R. J., Bell D. A. Catechol-O ... Li T., Vallada H., Curtis D., Arranz M., Xu K., Cai G., Deng H., Liu J., Murray R., Liu X., Collier D. A. Catechol-O- ... Lachman H. M., Papolos D. F., Saito T., Yu Y-M., Szumlanski C. L., Weinshilboum R. M. Human catechol-O-methyltransferase ...
Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate |...
Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate. Hong ... Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate. Hong ... Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate. Hong ... Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate ...
Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype<...
Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. British Journal ... Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. In: British ... Dive into the research topics of Aggressive behaviour in patients with schizophrenia is associated with catechol-O- ... Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. / Jones, G.; ...
Direct Evidence of Chelated Geometry of Catechol on TiO<sub>2</sub> by a Combined Solid-State NMR and DFT...
Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides. This ... N2 - Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides. This ... AB - Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides. This ... abstract = "Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides ...
167 Supramolecular M 4 L 4 tetrahedra based on triangular acylhydrazone catechol ligands • Schalley Group • Department of...
Supramolecular M4L4 tetrahedra based on triangular acylhydrazone catechol ligands. M. Albrecht, Y. Shang, T. Rhyssen, J. ... p,167,/p,,p,Supramolecular M,sub,4,/sub,L,sub,4,/sub, tetrahedra based on triangular acylhydrazone catechol ligands,/p, ... Supramolecular M4L4 tetrahedra based on triangular acylhydrazone catechol ligands ...
1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action...
1-hydroxy-2(1H)-pyridinone, catechol O-methyl transferase, Parkinsons disease. Subjects:. C700 Molecular Biology, Biophysics ... 1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action ... they are designed to be inhibitors of catechol O-methyl transferase, which contribute to the reduction of dopamine in the brain ... pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against ...
Catechols | Profiles RNS
"Catechols" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Catechols" by people in this website by year, and whether " ... Below are the most recent publications written about "Catechols" by people in Profiles. ...
Catechol Adhesives - Nanosfun
The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and...
catechol-O-methyltransferase (COMT); shizophrenia; alcohol dependence; smoking; association study. Subjects:. BIOMEDICINE AND ... The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and ... The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and ...
Opaline® | Solvay
Catechol 60 Vcaps, D'Adamo Personalized Nutrition - New Harmony
Catechol offers a unique three-layer design that provides optimal support for better health. The first layer contains a base of ... Be the first to review "Catechol 60 Vcaps, DAdamo Personalized Nutrition" Cancel reply. You must be logged in to post a review ... Every batch of Right 4 Your Types Catechol is made without the most common food allergens, and contains no artificial colors, ... Right 4 Your Type offers a product called Catechol, a natural dietary supplement that supports a personalized approach to ...
"Membrane-Bound (MB) Catechol-O-Methyltransferase (COMT) Genetic Polymo" by Y. Ji, James E. Olson et al.
COMT gene: MedlinePlus Genetics
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Learn about this gene and related ... Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L. Catechol-O-methyltransferase gene Val/Met ... Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which ... A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the ...
Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes :: MPG.PuRe
Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes ... 2019). Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes. Journal of the American Chemical Society, 141(36 ... Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes Hebel, M., Riegger, A., Zegota, M. M., Kizilsavas, G., ...
A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role...
N2 - We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol ... AB - We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol ... We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol ... The influence of the catechol moiety on the cytotoxicity and genotoxicity of new lignan derivatives has been investigated. The ...
The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion...
Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green ... The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion ... The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion ...
Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine 3',5' monophosphate (cAMP)...
T1 - Catechol estrogens (CE). T2 - inhibition of estrogen elicited stimulation of hypothalamic adenosine 3,5 monophosphate ( ... Paul S, Stalvey LP, Skolnick P. Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine ... Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine 3,5 monophosphate (cAMP) ... Paul, S., Stalvey, L. P., & Skolnick, P. (1977). Catechol estrogens (CE): inhibition of estrogen elicited stimulation of ...
Using a collection of nonfunctional missense mutants in the β-galactosidase and catechol 2,3-dioxygenase enzymes to better...
... β-galactosidase and catechol 2,3-dioxygenase. This collection of missense mutants yielded important information regarding the ... Using a collection of nonfunctional missense mutants in the β-galactosidase and catechol 2,3-dioxygenase enzymes to better ... Using a collection of nonfunctional missense mutants in the β-galactosidase and catechol 2,3-dioxygenase enzymes to better ... β-galactosidase and catechol 2,3-dioxygenase. This collection of missense mutants yielded important information regarding the ...
A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous...
The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. ... The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. PB - Wiley-Blackwell, ... The method is successfully applied for detection of catechol and hydroquinone in real samples analyses.", publisher = "Wiley- ... catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. It was found that oxidation current ...
Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol:...
Devanesan, P., Todorovic, R., Zhao, J., Gross, M. L., Rogan, E. G., & Cavalieri, E. L. (2001). Catechol estrogen conjugates and ... Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol: ... T1 - Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol ... Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol: ...
COMTDopamineOxidationGenotypeEstrogensEnzymeGeneAbstractReactionMoietyPhenolPolymorphismsVitroEnzymesReductiveStimulationNeurotransmittersMethylationConcentrationsBindsComplexesAcidTemperature158MetGenesPathwayVariationChemistryDescriptorMoietiesSubstancesDetectionBrainSensorUniqueIronStudyEffectsActivityTimeResultsTypeFoodPresenceProperties
COMT18
- The Minnesota Green Tea Trial was a 12-mo randomized, double-blind, placebo-controlled clinical trial of 937 healthy postmenopausal women assigned to either decaffeinated GTE (1315 mg total catechins/d) or a placebo, stratified by catechol-O-methyltransferase (COMT) genotype. (greenmedinfo.com)
- Although the aetiology of aggression is multifactorial, three studies have reported associations between polymorphisms of the catechol-O-methyltransferase (COMT) gene and aggression in schizophrenia. (elsevier.com)
- Membrane-Bound (MB) Catechol-O-Methyltransferase (COMT) Genetic Polymo" by Y. Ji, James E. Olson et al. (wright.edu)
- The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. (medlineplus.gov)
- The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain. (medlineplus.gov)
- Other tissues, including the liver, kidneys, and blood, produce a shorter form of the enzyme called soluble catechol-O-methyltransferase (S-COMT). (medlineplus.gov)
- A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain. (medlineplus.gov)
- However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of the levodopa dose reaches the brain unchanged. (nwu.ac.za)
- To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3 H- substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast and HEK293 cells) that had been transfected with the recombinant human transporters. (elsevier.com)
- Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. (ox.ac.uk)
- The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. (ox.ac.uk)
- Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. (omicsdi.org)
- Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. (omicsdi.org)
- Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. (omicsdi.org)
- By conducting a genetic study using the Genecept Assay, we were able to determine that the patient had overactive catechol- O -methyltranferase (COMT). (genomind.com)
- In humans, the catechol- O -methyltransferase protein is encoded by the COMT gene. (genomind.com)
- COMT, Catechol-O-methyl transferase, is an enzyme that degrades catecholamines-such as dopamine, epinephrine, and norepinephrine (or adrenaline and noradrenaline as they are called in the UK). (neuroamer.com)
- Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. (sunderland.ac.uk)
Dopamine2
- These compounds are expected to have a dual mode of action both beneficial against Parkinson's disease: they are designed to be inhibitors of catechol O-methyl transferase, which contribute to the reduction of dopamine in the brain, and to protect neurons against oxidative damage. (northumbria.ac.uk)
- 3. Oxidation resulted from the coordination of the dopamine catechol moiety to the center of metal and the transfer of electrons. (myprojectideas.com)
Oxidation7
- Under estrogenic imbalance, oxidation of catechol estrogens to quinones may complete with their detoxification by protective enzymes. (nebraska.edu)
- Also, SiG1 was applied as the catalyst for the oxidation of phenol and catechol in the presence of hydrogen peroxide. (ncku.edu.tw)
- The yields of Fe 2+ from SiG1 in the presence of catechol were limited by the equilibrium of reduction and the oxidation rate of iron(III, II) species. (ncku.edu.tw)
- Catechol induced the reductive dissolution of SiG1 and then promoted its own oxidation along with that of phenol in the presence of hydrogen peroxide. (ncku.edu.tw)
- By-products of catechol oxidation have demonstrated increased absorbance changes in a chitosan film in the UV and near UV range. (scitepress.org)
- Oxidation with hydrogen peroxide gives catechol (1,2-dihydroxybenzene). (chemeurope.com)
- Possible physiological effects were reported for cadmium and catechol only, which tended to increase the oxidation of proteins and hydrogen peroxide in the larvae. (bvsalud.org)
Genotype1
- Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations in a Randomized Controlled Trial of Overweight and Obese Postmenopausal Women. (greenmedinfo.com)
Estrogens1
- Formation of depurinating adducts by reaction of catechol estrogen-3,4-quinones with DNA was proposed to be a tumor initiating event by estrogens [E.L. Cavalieri et al. (nebraska.edu)
Enzyme1
- In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone iri vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. (elsevier.com)
Gene2
- Genome mining for VibH homologs reveals several species of Acinetobacter with a gene cluster that putatively encodes the biosynthesis of catechol siderophores with an amine core. (ucsb.edu)
- Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. (omicsdi.org)
Abstract1
- Abstract: The Southeast Asia Catechol market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by the end of 2024 with a CAGR of XX% from 2019 to 2024. (researchreporthub.com)
Reaction4
- IMSEAR at SEARO: Catechol stimulation of ferricyanide Hill reaction by spheroplasts of cyanobacterium, Synechococcus cedrorum: effect of temperature on catechol-stimulated oxygen evolution. (who.int)
- Upon reaction with catechol-derived quinones , we show that SifR dissociates from the DNA leading to regulon derepression, allowing the pneumococcus to access a catechol-derived source of Fe while minimizing reactive electrophile stress induced by quinones . (bvsalud.org)
- The temperature optimum of the reaction rate of Catechol 2,3-dioxygenase (C23O) from the selected isolates was between 40 and 50°C while optimum pH for C23O activity was within pH 6 and 8. (sciepub.com)
- Catechol intradiol dioxygenation is a unique reaction catalyzed by iron-dependent enzymes and non-heme iron(III) complexes. (cardiff.ac.uk)
Moiety2
- The influence of the catechol moiety on the cytotoxicity and genotoxicity of new lignan derivatives has been investigated. (abo.fi)
- The results obtained indicated that the presence of the catechol moiety sharply enhances the clastogenic potential (e. g. induction of chromosomal aberrations), the cytotoxicity and the modulation of cell cycle progression with respect to the parent compounds. (abo.fi)
Phenol3
- An original study of an immobilized iron oxide catalyst (SiG1) with one hydroxylation intermediate of phenol (catechol) in the reductive dissolution process was performed. (ncku.edu.tw)
- Only the hydroxylation intermediates of phenol (i.e. catechol and 1,4-hydroquinone) were able to reductively dissolve SiG1. (ncku.edu.tw)
- We report the successful fabrication and testing of an optical MEMS sensor for the detection of the toxic phenol, catechol. (scitepress.org)
Polymorphisms1
- Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. (nih.gov)
Vitro2
- Thus, despite the in vitro antioxidant activity usually described for catechol derivatives, our results show for the first time the generation of a clastogenic potential, highly indicative of a long-term genetic and cancer risk. (abo.fi)
- Effects of 4-tertiary butyl catechol on glutathione-metabolizing enzymes in vivo and in vitro. (cdc.gov)
Enzymes1
- In order to better understand how missense mutants affect protein structure, a set of randomly generated nonfunctional missense mutants were isolated in two well-characterized enzymes, β-galactosidase and catechol 2,3-dioxygenase. (mtsu.edu)
Reductive2
- The reductive dissolution of SiG1 not only occurred at acidic solution but also occurred at alkali solution in the presence of catechol. (ncku.edu.tw)
- Silver nanoparticles are spontaneously formed inside of the PVCa phases due to the reductive properties of the catechol moieties. (elsevier.com)
Stimulation1
- Catechol(o-dihydroxybenzene) at low concentrations (20-100 microM) stimulates FeCN-dependent O2 evolution of spheroplasts isolated from the cyanobacterium Synechococcus both in the presence and absence of DBMIB, an inhibitor of electron flow from PSII to PSI, the stimulation being two-fold with saturating concentration of (60 microM) catechol. (who.int)
Neurotransmitters3
- In the brain, catechol-O-methyltransferase helps break down certain chemical messengers called neurotransmitters. (medlineplus.gov)
- Catechol-O-methyltransferase helps maintain appropriate levels of these neurotransmitters in this part of the brain. (medlineplus.gov)
- The change affects the stability and activity of catechol-O-methyltransferase, which alters the enzyme's ability to break down neurotransmitters in the prefrontal cortex. (medlineplus.gov)
Methylation2
- A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). (abo.fi)
- We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol derivatives by using IBX as primary oxidant under green conditions (dimethyl carbonate-H(2)O solvent) through an in situ reduction procedure. (abo.fi)
Concentrations2
- Catechol-2,3-dioxygenase activity was determined by spectrophotometric method and the unit activity was calculated from standard curve prepared from varying concentrations of 2-hydroxymuconic aldehyde while lipolytic activity was determined by colorimetric method based on the activity in cleavage of p-nitrophenylpalmitate (p-NPP) at pH 8.0. (sciepub.com)
- Concentrations as low as 1 mM catechol are detected while control experiments including ascorbic acid display no measurable response. (scitepress.org)
Binds2
- Previous work established that membrane -anchored PiuA binds FeIII-bis-catechol or monocatechol complexes with high affinity, including the human catecholamine stress hormone , norepinephrine . (bvsalud.org)
- Using a combination of kinetic measurements and computational modelling of multiple iron(III) catecholato complexes, we have elucidated the catechol cleavage mechanism and show that oxygen binds the iron center by partial dissociation of the substrate from the iron complex. (cardiff.ac.uk)
Complexes2
- Consistent with this model, we show that CatE is an FeII-dependent 2,3-catechol dioxygenase with broad substrate specificity , YwnB is an NAD (P)H-dependent quinone reductase capable of reducing the oxidized and cyclized norepinephrine , adrenochrome , and YhdA is capable of reducing a number of FeIII complexes, including PiuA-binding transport substrates . (bvsalud.org)
- These findings are consistent with a model where FeIII-catechol complexes serve as significant nutritional Fe sources in the host. (bvsalud.org)
Acid3
- I thought of another, more economical idea for synthesizing catechol (since acetylsalicylic acid isn't exactly inexpensive). (sciencemadness.org)
- The 2-hydroxyltoluene would be oxidized, then reacted with urea, then treated with calcium hypochlorite, and then diazotized with nitrous acid to yield catechol. (sciencemadness.org)
- Our data show, for the first time, that caffeine, catechols and N-alkanoly-5-hydroxytryptamides are those coffee components that stimulate molecular mechanisms of stomach acid secretion in human stomach cells," Somoza said. (eurekalert.org)
Temperature3
- attack a condenser to the flask, and heat to 240°C(bp of catechol) and keep on this temperature until no more catechol is distilled. (sciencemadness.org)
- Analysis of the temperature effect on FeCN-supported O2 evolution by spheroplasts suggests that catechol shifts the temperature maxima to a lower temperature and thereby hastens the decay of O2 evolution capacity by heat as compared to the normal spheroplasts. (who.int)
- Catechol also induces a change in the magnitude of activation energy for ferricyanide Hill activity of spheroplasts and lowers the transition temperature. (who.int)
158Met1
- Pivac, Nela (2013) The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence . (irb.hr)
Genes1
- Global transcriptomic analysis of a ΔsifR strain defines the SifR regulon as genes encoding a candidate catechol dioxygenase CatE, an uncharacterized oxidoreductase YwnB, a candidate flavin-dependent ferric reductase YhdA, a candidate heme -based ferric reductase domain-containing protein and the Piu ( pneumococcus iron uptake) Fe transporter (piuBCDA). (bvsalud.org)
Pathway1
- Third, the most efficient protocatechuate decarboxylase AroY for conversion of the midstream pathway intermediate protocatechuate into catechol was identified out of several variants in native and codon optimized form and expressed together with the respective helper proteins. (bvsalud.org)
Variation2
- The full functional implications of pharmacogenetic variation in the activities of catechol O-methyltransferase and histamine N-methyltransferase remain to be determined. (nih.gov)
- Most studies have focused on the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase. (medlineplus.gov)
Chemistry1
- The activity of the company consists in the design, development, formulation and optimization of bioinspired polymeric products based on the chemistry of catechols and thiols/disulfides that have physical and chemical properties that make them very suitable for the formulation of adhesives with application in the biomedical field, such as tissue repair, sutures and surgical interventions among others. (nanosfun.com)
Descriptor1
- Catechols" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Moieties1
- Plant-derived phenolic compounds, rich in catechol and pyrogallol moieties, can form multifunctional coatings on various substrates following polymerization under mildly alkaline conditions. (kit.edu)
Substances1
- These substances include caffeine, catechols, and other ingredients. (eurekalert.org)
Detection2
- Such prepared electrode was utilized for successive simultaneous detection of structurally similar compounds, 1,2- and 1,4-dihydroxibenzenes (catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. (ac.rs)
- The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. (ac.rs)
Brain1
- Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which organizes and coordinates information from other parts of the brain. (medlineplus.gov)
Sensor2
- SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39. (bvsalud.org)
- Our reported sensor takes advantage of this unique absorbance property to detect catechol by measuring the change in light intensity at 472 nm, thus eliminating non-specific responses that occur from other oxidized chemicals which do not cause the absorbance change. (scitepress.org)
Unique2
- Catechol offers a unique three-layer design that provides optimal support for better health. (newharmony.ie)
- In the present work, poly(vinyl catechol-block-styrene) PVCa-b-PSt synthesized with various compositions forms unique microphase-separated structures. (elsevier.com)
Iron2
- The SiG1 used in this study reacted more efficiently with catechol than the other iron oxides. (ncku.edu.tw)
- Here, we aimed at measuring the physiological responses of the black soldier fly H. illucens grown on food wastes (kitchen, fruit or vegetable wastes) contaminated by cadmium, iron, lead or catechol. (bvsalud.org)
Study1
- In the present work, we report a solid-state NMR and DFT study of catechol on TiO 2 . (elsevier.com)
Effects2
- The effects of noncytotoxic doses of 4-tertiary-butyl-catechol (98293) (TBC) on glutathione-S-transferase (GST) activity in the skin of male, 2 month old Uscd-mice and B16-murine-melanoma cells in culture were investigated. (cdc.gov)
- However, organic wastes, including food wastes, may contain several pollutants such as heavy metals and catechol which could affect the bioconversion efficiency by incurring physiological costs that would be undetectable at the organismal level, i.e. have null to little effects on the life cycle of Hermetia illucens. (bvsalud.org)
Activity1
- Little is known, however, about the relationship between catechol-O-methyltransferase activity and the specific mental and emotional problems characteristic of this condition. (medlineplus.gov)
Time1
- I have been interested in preparing Benzene-1,2-diol (catechol) for some time. (sciencemadness.org)
Results2
- These results suggest that lipophilic catechol brings about an alteration in membrane fluidity in cyanobacterial spheroplasts. (who.int)
- Nandrolone is a deca-Durabolin (to which a decanter is added to boost the chemical structure) in which testosterone is combined with the drug nandrolone and other bioactive ingredient, such as the naturally occurring estrogenic and aromatherapositive chemical Estradiol, and/or the bisphenol F, the bisphenol S and catechol and other compounds, deca durabolin 100mg injection results in hindi. (noahsarkctcf.com)
Type1
- Right 4 Your Type offers a product called Catechol, a natural dietary supplement that supports a personalized approach to nutritional stress support by helping to restore a state of calm and support optimal neurotransmitter balance. (newharmony.ie)
Food2
- Every batch of Right 4 Your Type's Catechol is made without the most common food allergens, and contains no artificial colors, preservatives, flavors, or other ingredients. (newharmony.ie)
- We found no evidence of deleterious impacts of food waste contamination by catechol or heavy metals on H. illucens. (bvsalud.org)
Presence1
- A kinetic model was applied to obtain the estimated maximum concentration of Fe 2+ produced by SiG1 and estimated proportional constant in the presence of catechol at different pH conditions by using a trial and error method. (ncku.edu.tw)
Properties1
- We investigate the absorption properties of two catechol-like molecules, i.e. (42papers.com)