OrganismsChemicals and DrugsPhenomena and ProcessesHealth Care
CatecholsCatechol 2,3-DioxygenaseEstrogens, CatecholCatechol 1,2-DioxygenaseCatechol O-MethyltransferaseDioxygenasesOxygenasesCatechol OxidasePhenolHydroxybenzoatesSorbic AcidEquileninPseudomonasBenzoatesBiodegradation, EnvironmentalPseudomonas putidaBenzenePyrogallolPhenolsBenzoic AcidAdipatesChlorobenzenesCresolsHydroxyestronesTolueneHydroquinonesChlorobenzoatesPlanococcus BacteriaAcinetobacterAlcaligenesRhodococcusMixed Function OxygenasesSiderophoresQuinonesMonophenol MonooxygenasePseudomonas mendocinaOxidation-ReductionToluidinesAdrenochromeGentisatesSalicylatesBenzophenonesNormetanephrineRalstoniaHydroxylationCatecholaminesXylenesGram-Negative Aerobic Rods and CocciSubstrate SpecificityParabensGenes, Bacterial
Catechols
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Catechol 2,3-Dioxygenase
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
Estrogens, Catechol
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.
Catechol 1,2-Dioxygenase
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.
Catechol O-Methyltransferase
Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.
Dioxygenases
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
Oxygenases
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
Catechol Oxidase
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.
Phenol
An antiseptic and disinfectant aromatic alcohol.
Hydroxybenzoates
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
Sorbic Acid
Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.
Equilenin
An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.
Pseudomonas
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
Benzoates
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Biodegradation, Environmental
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Pseudomonas putida
A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Pyrogallol
A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.
Phenols
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Benzoic Acid
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
Adipates
Derivatives of adipic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,6-carboxy terminated aliphatic structure.
Chlorobenzenes
Cresols
Hydroxyestrones
Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Toluene
A widely used industrial solvent.
Hydroquinones
Chlorobenzoates
Benzoic acid or benzoic acid esters substituted with one or more chlorine atoms.
Planococcus Bacteria
A genus of coccoid bacteria in the family PLANOCOCCACEAE. They are widely distributed in various habitats including sea water, freshwater ponds, cyanobacterial mats, and in marine animals.
Acinetobacter
A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.
Alcaligenes
A genus of gram-negative, aerobic, motile bacteria that occur in water and soil. Some are common inhabitants of the intestinal tract of vertebrates. These bacteria occasionally cause opportunistic infections in humans.
Rhodococcus
A bacterial genus of the order ACTINOMYCETALES.
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Siderophores
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
Quinones
Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Monophenol Monooxygenase
An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.
Pseudomonas mendocina
A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Toluidines
Adrenochrome
Pigment obtained by the oxidation of epinephrine.
Gentisates
Salts and esters of gentisic acid.
Salicylates
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
Benzophenones
Normetanephrine
A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.
Ralstonia
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
Hydroxylation
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
Catecholamines
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Xylenes
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Gram-Negative Aerobic Rods and Cocci
A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Parabens
Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)
Genes, Bacterial
The functional hereditary units of BACTERIA.

Action of 3 tyrphostin derivatives on casein kinase II from rat liver. (1/1002)

AIM: To study the action of tyrphostin on casein kinase (CK) II. METHODS: CK II was partially purified from rat livers by sequential DE52 and heparin-Sepharose chromatography. CK II activity was assayed by incubating CK II with dephosphorylated casein and [gamma-32P]ATP. RESULTS: AG34 inhibited the activity of CK II with IC50 33 (27-41) mumol.L-1. Both AG372 (121 mumol.L-1) and AG1112 (150 mumol.L-1) displayed inhibitory effects on the activity of CK II. Kinetic studies of AG34 on CK II showed that it was noncompetitive with casein and ATP. CONCLUSION: AG34, AG372, and AG1112 were potent inhibitors of CK II, and the inhibitory action of AG34 was noncompetitive with casein and ATP.  (+info)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/1002)

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity.  (+info)

Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (3/1002)

We identified and characterized a methyl transfer activity of the toluate cis-dihydrodiol (4-methyl-3,5-cyclohexadiene-cis-1, 2-diol-1-carboxylic acid) dehydrogenase of the TOL plasmid pWW0 towards toluene cis-dihydrodiol (3-methyl-4,5-cyclohexadiene-cis-1, 2-diol). When the purified enzyme from the recombinant Escherichia coli containing the xylL gene was incubated with toluene cis-dihydrodiol in the presence of NAD+, the end products differed depending on the presence of adenosylcobalamin (coenzyme B12). The enzyme yielded catechol in the presence of adenosylcobalamin, while it gave 3-methylcatechol in the absence of the cofactor. Adenosylcobalamin was transformed to methylcobalamin as a result of the enzyme reaction, which indicates that the methyl group of the substrate was transferred to adenosylcobalamin. Other derivatives of the cobalamin such as aquo (hydroxy)- and cyanocobalamin did not mediate the methyl transfer reaction. The dehydrogenation and methyl transfer reactions were assumed to occur concomitantly, and the methyl transfer reaction seemed to depend on the dehydrogenation. To our knowledge, the enzyme is the first dehydrogenase that shows a methyl transfer activity as well.  (+info)

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. (4/1002)

Earlier study suggested that 3,4-dihydroxytamoxifen (tam catechol), a tamoxifen metabolite, is proximate to the reactive intermediate that binds covalently to proteins and possibly to DNA (). The current study demonstrates that rat and human hepatic cytochrome P-450s (CYPs) catalyze tam catechol formation from tamoxifen (tam), 3-hydroxy-tam (Droloxifene), and 4-hydroxy-tam (4-OH-tam). Higher levels of catechol were formed from 4-OH-tam and 3-hydroxy-tam than from tam. Evidence that human hepatic CYP3A4 and 2D6 catalyze the formation of tam catechol from 4-OH-tam and supportive data that the catechol is proximate to the reactive intermediate, was obtained: 1) There was a good correlation (r = 0.82; p +info)

Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats. (5/1002)

AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2. Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of 63Ni was shown by the whole-body autoradiography. RESULTS: CBMIDA s.c. 0.5-1.5 g.kg-1 markedly reduced the mortality from acute poisoning of i.p. NiCl2 500 mg.kg-1. After i.p. NiCl2 in mice, the LD50 was 82.7 mg.kg-1. Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively. The LD50 of NiCl2 was 39 mg.kg-1 in rat. If CBMIDA was injected i.m. 0.5 g.kg-1 after i.p. NiCl2, the LD50 was 332 mg.kg-1. CBMIDA 1.5 g.kg-1 i.m. after i.v. 63NiCl2, decreased the contents of 63Ni in blood and lung of mice vs control mice at 24 h. The contents of 63Ni in brain, heart, spleen, and kidney were similar to those of the control mice. The content of 63Ni in bone was more than the control. The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiography showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of 63Ni in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. There was a marked reduction of 63Ni in the lung, skin, liver, and blood after i.p. CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice and rats, and decreased 63Ni levels in lung and blood.  (+info)

Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. (6/1002)

Two Escherichia coli transformants with catechol 1,2-dioxygenase activity were selected from a gene library of the benzamide-assimilating bacterium Arthrobacter species strain BA-5-17, which produces four catechol 1,2-dioxygenase isozymes. A DNA fragment isolated from one transformant contained a complete open reading frame (ORF). The deduced amino acid sequence of the ORF shared high identity with hydroxyquinol 1,2-dioxygenase. An enzyme expressed by the ORF was purified to homogeneity and characterized. When hydroxyquinol was used as a substrate, the purified enzyme showed 6.8-fold activity of that for catechol. On the basis of the sequence identity and substrate specificity of the enzyme, we concluded that the ORF encoded hydroxyquinol 1,2-dioxygenase. When catechol was used as a substrate, cis,cis-muconic acid and 2-hydroxymuconic 6-semialdehyde, which were products by the intradiol and extradiol ring cleavage activities, respectively, were produced. These results showed that the hydroxyquinol 1,2-dioxygenase reported here was a novel dioxygenase that catalyzed both the intradiol and extradiol cleavage of catechol.  (+info)

Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (7/1002)

The inotropic/lusitropic effects of beta-adrenergic agonists on the heart are mediated largely by protein kinase A (PKA)-catalyzed phosphorylation of phospholamban, the natural protein regulator of the Ca2+ pump present in sarcoplasmic reticulum (SR) membranes. Gingerol, a plant derivative, is known to produce similar effects when tested in isolated cardiac muscle. The purpose of the present study was to compare the effects of gingerol and another plant derivative, ellagic acid, on the kinetics of the SR Ca2+ pump with those of PKA-catalyzed phospholamban phosphorylation to elucidate their mechanisms of Ca2+ pump regulation. As previously demonstrated for PKA, 50 microM gingerol or ellagic acid increased Vmax(Ca) of Ca2+ uptake and Ca2+-ATPase activity assayed at millimolar ATP concentrations in light cardiac SR vesicles. Unlike PKA, which decreases Km(Ca), neither compound had a significant effect on Km(Ca) in unphosphorylated vesicles. However, gingerol increased Km(Ca) in phosphorylated vesicles, in which Ca2+ uptake was significantly increased further at saturating Ca2+ and remained unchanged at subsaturating Ca2+. An inhibition of Ca2+ uptake by gingerol at micromolar MgATP concentrations was overcome with increasing MgATP concentrations. The stimulation of Ca2+ uptake attributable to gingerol in unphosphorylated microsomes at saturating Ca2+ was 30% to 40% when assayed at 0.05 to 2 mM MgATP and only about 12% in phosphorylated microsomes as well as in rabbit fast skeletal muscle light SR. The present results support the view that an ATP-dependent increase in Vmax(Ca) of the SR Ca2+ pump plays an important role in mediating cardiac contractile responses to gingerol and phospholamban-dependent beta-adrenergic stimulation.  (+info)

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. (8/1002)

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. A polymorphism in NQO1, a C609T substitution, has been identified, and individuals homozygous for this change (T/T) have no detectable NQO1. Exposed workers with a T/T genotype have an increased risk of benzene hematotoxicity. This finding suggests NQO1 is protective against benzene toxicity, which is difficult to reconcile with the lack of detectable NQO1 in human bone marrow. The human promyeloblastic cell line, KG-1a, was used to investigate the ability of the benzene metabolite hydroquinone (HQ) to induce NQO1. A concentration-dependent induction of NQO1 protein and activity was observed in KG-1a cells cultured with HQ. Multiple detoxification systems, including NQO1 and glutathione protect against benzene metabolite-induced toxicity. Indeed, exposure to a noncytotoxic concentration of HQ induced both NQO1 and soluble thiols and protected against HQ-induced apoptosis. NQO1 protein and activity increased in wild-type human bone marrow cells (C/C) exposed to HQ, whereas no NQO1 was induced by HQ in bone marrow cells with the T/T genotype. Intermediate induction of NQO1 by HQ was observed in heterozygous bone marrow cells (C/T). NQO1 also was induced by HQ in wild-type (C/C) human bone marrow CD34(+) progenitor cells. Our data suggest that failure to induce functional NQO1 may contribute to the increased risk of benzene poisoning in individuals homozygous for the NQO1 C609T substitution (T/T).  (+info)

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http://www.allscrabblewords.com/word-description/pyrocatechol
Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis...
TY - JOUR. T1 - Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis. AU - Lih, Eugene. AU - Choi, Seul Gi. AU - Ahn, Dong June. AU - Joung, Yoon Ki. AU - Han, Dong Keun. PY - 2016/2/13. Y1 - 2016/2/13. N2 - Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelialization. Especially, we were interested in how much amount of catechol group is appropriate for the above-mentioned purposes. Therefore, a series of dopamine-conjugated hyaluronic acid conjugates with different ratios of catechol group were synthesized via a carbodiimide coupling reaction. Dopamine-conjugated hyaluronic acid ...
https://koreauniv.pure.elsevier.com/en/publications/optimal-conjugation-of-catechol-group-onto-hyaluronic-acid-in-cor
Kinetics and Mechanism of Birnessite Reduction by Catechol by Christopher J. Matocha, Donald L. Sparks et al.Kinetics and Mechanism of Birnessite Reduction by Catechol by Christopher J. Matocha, Donald L. Sparks et al.
The complex interactions of oxidizable organic ligands with soil Mn(III,IV) (hydr)oxide minerals have received little study by in situspectroscopic techniques.We used a combination of an in situ electron paramagnetic resonance stopped-flow (EPR-SF) spectroscopic technique and stirred-batch studies to measure the reductive dissolution kinetics of birnessite (δ-MnO2), a common Mn mineral in soils, by catechol (1,2-dihydroxybenzene). The reaction was rapid, independent of pH, and essentially complete within seconds under conditions of excess catechol at pH 4 to 6. The overall empirical second-order rate equation describing the reductive dissolution rate was d[Mn(II)]/dt = k[CAT]1.0[SA]1.0 where k = 4 (±0.5) (10-3 L m-2 s-1 and [CAT] and [SA] are the initial concentrations in molarity and meters square per liter. In the process, catechol was oxidized to the two-electron o-quinone product. The energy of activation (Ea) for the reaction was 59 (±7) kJ mol-1 and the activation entropy (S‡) was- -78±22 J
https://digitalcommons.unl.edu/usdoepub/172/
Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in...Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in...
para-Nitrophenol (PNP) is a highly toxic compound with threats to mammalian health. The pnpE-encoded γ-hydroxymuconic semialdehyde dehydrogenase catalyzes the reduction of γ-hydroxymuconic semialdehyde to maleylacetate in Pseudomonas sp. strain WBC-3, playing a key role in the catabolism of PNP to Krebs cycle intermediates. However, the catalyzing mechanism by PnpE has not been well understood. Here we report the crystal structures of the apo and NAD bound PnpE. In the PnpE-NAD complex structure, NAD is situated in a cleft of PnpE. The cofactor binding site is composed of two pockets. The adenosine and the first ribose group of NAD bind in one pocket and the nicotinamide ring in the other. Six amino acids have interactions with the cofactor. They are C281, E247, Q210, W148, I146 and K172. Highly conserved residues C281 and E247 were identified to be critical for its catalytic activity. In addition, flexible docking studies of the enzyme-substrate system were performed to predict the interactions
https://bmcstructbiol.biomedcentral.com/articles/10.1186/1472-6807-13-30/figures/6
BRENZKATECHINVIOLETT (pyrocatechol violet): Topics by WorldWideScience.orgBRENZKATECHINVIOLETT (pyrocatechol violet): Topics by WorldWideScience.org
Spectrophotometric determination of tin in copper-based alloys using Pyrocatechol Violet Spinola Costa, A.; Teixeira, L. S. G.; Ferreira, S. L. C. ...
https://worldwidescience.org/topicpages/multi/DE/p/pyrocatechol+violet.html
Team:Lethbridge/Project - 2011.igem.orgTeam:Lethbridge/Project - 2011.igem.org
To address the decontamination of (1) toxic organic compounds such as naphthene and catechol found in the tailings ponds, natural pathways that can break down the toxic chemicals can be utilized. The toxic organic compounds can be broken down into molecules that are metabolizable by all organisms, such as 2-hydroxymuconic semialdehyde (2-HMS)3. Catechol is a prime candidate to function as a hub for the funneling and subsequent degradation of other toxic compounds found in abundance, such as naphthene, anthracene, and fluorene into 2-HMS (Figure 1)3,4,5. Catechol 2,3-dioxygenase (xylE) is found in Pseudomonas putida and hydrolyzes catechol into 2-HMS, which can enter the citric acid cycle6. In 2010, the Lethbridge iGEM team confirmed that xylE when introduce to E. coli hydrolyzes catechol to 2-HMS demonstrating and that this critical step can successfully be performed to convert toxic chemicals to metabolic intermediates7. XylE is inefficient on its own, especially in vitro, due to instability ...
http://2011.igem.org/wiki/index.php?title=Team:Lethbridge/Project&diff=prev&oldid=263237
Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical JournalMicrosomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical Journal
1. The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was detected and isolated after microsomal incubations of the diols. 3. The accompanying reduction of NAD+ was followed spectrophotometrically. 4. The optimum pH for the microsomal reaction was 9·4 for the oxidation of the cis-diol and 9·8 for that of the trans-diol. 5. p-Chloromercuribenzoate and 2,4-dichlorophenol inhibited the reaction. 6. Possible mechanisms for the microsomal ring-fission, involving 1,8-naphthalic aldehyde, are discussed.. ...
http://www.biochemj.org/content/108/4/577
One Mystery Of How Mussels Stick To Rocks, Boats SolvedOne Mystery Of How Mussels Stick To Rocks, Boats Solved
When mussels wish to settle down on an underwater surface, they secrete mixtures of adhesive proteins that often contain high concentrations of a rare amino acid called Dopa (3,4-dihydroxyphenylalanine). Catechol groups on Dopa play a major role in underwater adhesion. The new work reveals that in addition to Dopa, many mussel adhesion proteins contain positively-charged lysine residues nearby to aid sticking. The lysines replace layers of salt-derived cations found on surfaces submerged in seawater. By kicking off the cations, the lysines prime the underwater surface so that catechol groups can then help the mussel adhere.. ...
https://cen.acs.org/articles/93/web/2015/08/One-Mystery-Mussels-Stick-Rocks.html?utm_source=YMAL&utm_medium=YMAL&utm_campaign=CEN&utm_content=pos3
Team:Toronto/Results - 2010.igem.orgTeam:Toronto/Results - 2010.igem.org
In order to determine which enzymes would most benefit from metabolic channeling in the catechol degradation pathway, we used a cellular simulation tool, developed in our lab, called Cell++. It allows us to place enzymes of choice in a compartment within a cellular environment and calculates the effect of localization on metabolite concentrations in a user-defined biochemical pathway (Sanford et al. 2006). We gathered kinetic data of the five enzymes in the degradation pathway and investigated the effects of localizing pairs of sequential enzymes (i.e. catechol 1, 2-dioxygenase and muconate cycloisomeras) on metabolite concentrations. Four co-localization simulations were performed in Cell++ along with a control simulation where no enzymes were co-localized. The initial metabolite in the simulation environment, catechol, was added into the simulation environment and the simulation environment was run for 10,000 iterations to observe the effect on catechol degradation in each simulation. The ...
http://2010.igem.org/wiki/index.php?title=Team:Toronto/Results&diff=176782&oldid=150079
Team:Toronto/Results - 2010.igem.orgTeam:Toronto/Results - 2010.igem.org
In order to determine which enzymes would most benefit from metabolic channeling in the catechol degradation pathway, we used a cellular simulation tool, developed in our lab, called Cell++. It allows us to place enzymes of choice in a compartment within a cellular environment and calculates the effect of localization on metabolite concentrations in a user-defined biochemical pathway (Sanford et al. 2006). We gathered kinetic data of the five enzymes in the degradation pathway and investigated the effects of localizing pairs of sequential enzymes (i.e. catechol 1, 2-dioxygenase and muconate cycloisomeras) on metabolite concentrations. Four co-localization simulations were performed in Cell++ along with a control simulation where no enzymes were co-localized. The initial metabolite in the simulation environment, catechol, was added into the simulation environment and the simulation environment was run for 10,000 iterations to observe the effect on catechol degradation in each simulation. The ...
http://2010.igem.org/wiki/index.php?title=Team:Toronto/Results&diff=cur&oldid=153085
Bis(O-(N-benzyl-N-(1,1-dimethylethoxy)carbonyl-ethylamine)) Catechol | CAS: 1391054-05-9 | Bis(O-(N-benzyl-N-(1,1...Bis(O-(N-benzyl-N-(1,1-dimethylethoxy)carbonyl-ethylamine)) Catechol | CAS: 1391054-05-9 | Bis(O-(N-benzyl-N-(1,1...
Clinivex is a high quality reference standard supplier of Bis(O-(N-benzyl-N-(1,1-dimethylethoxy)carbonyl-ethylamine)) Catechol, CAS no - 1391054-05-9. View more information regarding Bis(O-(N-benzyl-N-(1,1-dimethylethoxy)carbonyl-ethylamine)) Catechol, in
https://theclinivex.com/biso-n-benzyl-n-1-1-dimethylethoxycarbonyl-ethylamine-catecholl.html
Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.orgTeam:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org
This section needs work. Why are we degrading catechol? What part did we use? What is the number?. Catechol is another toxic compound found in tailings ponds that is a by-product of polyaromatic hydrocarbon metabolism (Vaillancourt et al., 2006, Schweigert et al., 2001)). The chemical properties of catechol allow it to react with biomolecules like DNA, proteins and membranes (Schweigert et al., 2001). These interactions can cause serious damage including DNA breakage, enzyme inactivation and membrane uncoupling (Schweigert et al., 2001). Catechol is characterized as having a benzene ring with two hydroxyl groups emanating from adjacent carbons. It can be converted to 2-hydroxymuconic acid by the enzyme catechol 2,3-dioxygenase, encoded by the xylE gene on the Tol plasmid of Pseudomonas putida (Nakai et al., 1983). This product can then be further metabolized to pyruvate and acetaldehyde; products which can then be routed into the fatty acid biosynthesis pathway and converted to alkanes with the ...
http://2012.igem.org/wiki/index.php?title=Team:Calgary/Project/OSCAR/CatecholDegradation&diff=259251&oldid=257954
The gene cluster, coding for the chlorocatechol sp. of hereditary, biochemical, - The proteasome: structure, function, and role...The gene cluster, coding for the chlorocatechol sp. of hereditary, biochemical, - The proteasome: structure, function, and role...
The gene cluster, coding for the chlorocatechol sp. of hereditary, biochemical, and ecological areas of the connections of several chloroaromatic substances with microorganisms in the biosphere within a broad work to comprehend the fate of the chemicals in the surroundings also to develop book bioremediation strategies (22, 33, 37). Among the principles to emerge out of this body of function is the department of biodegradative routes into higher and lower pathways that are linked with the central intermediate chlorocatechol (38). Hereditary research of chlorocatechol sp. stress P51 and sp. stress PS12: an entire mineralization pathway seems to have advanced through transposon-mediated recruitment of toluene or benzene dioxygenase and dihydrodiol dehydrogenase genes following to a gene cluster coding for an gene cluster, hereafter known as the gene cluster) in the trichlorobenzene-degrading stress sp. stress P51 (41) within a Tnchlorocatechol catabolic genes are organized within an operon and ...
http://www.globaltechbiz.com/2017/10/16/the-gene-cluster-coding-for-the-chlorocatechol-sp-of-hereditary-biochemical/
Catechol boronate formation and its electrochemical oxidation - Chemical Communications (RSC Publishing)Catechol boronate formation and its electrochemical oxidation - Chemical Communications (RSC Publishing)
The reversible boronate formation between electrochemically active substituted catechols and a fluorescent boronic acid was studied in methanol.
https://pubs.rsc.org/en/content/articlelanding/2009/CC/b900016j
Team:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.orgTeam:Calgary/Project/OSCAR/CatecholDegradation - 2012.igem.org
After verifying that we could in fact degrade catechol into 2-hydroxymuconate semialdehyde using our xylE construct (BBa_J33204), we wondered if we could take this any further. What if we could convert this by-product page into hydrocarbons too? As catechol is the breakdown product of a number of different degradation pathways in bacteria, this could be particularly useful.. As 2-hydroxymuconate semialdehyde can be further metabolized to pyruvate and acetaldehyde (Harayama S et al., 1987), it seemed possible that these products could be routed into the fatty acid biosynthesis pathway and converted to alkanes using the PetroBrick or the OleT enzyme. Given that the Catechol 2,3-dioxygenase reaction is extracellular, it creates a possible scenario in which cells with the xylE construct could be co-cultured with Petrobrick-containing cells to cooperatively metabolise catechol into hydrocarbons. In order to test this, we followed this protocol, where we co-cultured cells expressing our xylE construct ...
http://2012.igem.org/wiki/index.php?title=Team:Calgary/Project/OSCAR/CatecholDegradation&diff=264804&oldid=264515
In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates | 10.1007/s11164...In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates | 10.1007/s11164...
Read In situ surface modification of colloidal TiO2 nanoparticles with catechol, Research on Chemical Intermediates on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/in-situ-surface-modification-of-colloidal-tio2-nanoparticles-with-q7pJPYRtEk
229. Does labetolol provide sufficient alpha blockade to use in high catechol states? / Dose and use of esmolol /...229. Does labetolol provide sufficient alpha blockade to use in high catechol states? / Dose and use of esmolol /...
229. Does labetolol provide sufficient alpha blockade to use in high catechol states? / Dose and use of esmolol / Contraindications to esmolol / Dose of ...
https://emupdates.com/229-does-labetolol-provide-sufficient-alpha-blockade-to-use-in-high-catechol-states-dose-and-use-of-esmolol-contraindications-to-esmolol-dose-of-phentolamine/
SearchSearch
Public health and environmental protection concerns provoked by phenolic compounds pollution impose the development of sensitive, rapid and cost effective methods for in situ phenols monitoring. Given that biosensors based techniques could face these challenges, a variety of such devices was suggested and applied for phenolic compounds quantification. Their majority are based on the polyphenol oxidase (PPO) catalyzed phenols oxidation to catechol and then, to quinones, coupled with the registration of the quinones reduction current. Nevertheless, quinoid products polymerization involving electrode passivation corrupts the biosensors operational stability. Thus, to avoid this drawback, in this work is proposed another approach for phenolic compounds quantification based on the electrochemical detection of the oxygen depletion during PPO catalyzed catechol oxidation using a Clark type electrode with a disposable active enzyme membrane. The oxygen probe was modified in comparison to the commercial ...
https://core-cms.prod.aop.cambridge.org/core/search?filters%5BauthorTerms%5D=B.%20Valdez&eventCode=SE-AU
Comtan (Entacapone): Side Effects, Interactions, Warning, Dosage & UsesComtan (Entacapone): Side Effects, Interactions, Warning, Dosage & Uses
Learn about Comtan (Entacapone) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
https://www.rxlist.com/comtan-drug.htm
mhpE - 4-hydroxy-2-oxovalerate aldolase - Escherichia coli (strain K12) - mhpE gene & proteinmhpE - 4-hydroxy-2-oxovalerate aldolase - Escherichia coli (strain K12) - mhpE gene & protein
Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of 3-phenylpropanoate.
https://www.uniprot.org/uniprot/P51020
dcyphr | Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease APA citation (Click to edit): Smirnova, N. A., Kaidery, N. A., Hushpulian, D. M., Rakhman, I. I., Poloznikov, A. A., Tishkov, V. I., ... and Gazaryan, I. G. (2016). Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinsons Disease. Aging and Disease, 7(6), 745. doi: 10.14336/AD.2016.0505 DOI (Click to edit): 10.14336/AD.2016.0505 ...
https://dcyphr.org/history/292
TCI AMERICAS 4-Nitrocatechol,5g - 20EM61|N0273-5G - GraingerTCI AMERICAS 4-Nitrocatechol,5g - 20EM61|N0273-5G - Grainger
Looking for TCI AMERICAS 4-Nitrocatechol,5g (20EM61)? Graingers got your back. Price:$92.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
https://www.grainger.com/product/TCI-AMERICAS-TCI-3316-09-4-20EM61
TCI AMERICAS 4-Chlorocatechol,25g - 29LF61|C0568-25G - GraingerTCI AMERICAS 4-Chlorocatechol,25g - 29LF61|C0568-25G - Grainger
Looking for TCI AMERICAS 4-Chlorocatechol,25g (29LF61)? Graingers got your back. Price:$723.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
https://www.grainger.com/product/TCI-AMERICAS-TCI-2138-22-9-29LF61
Catechol, 99+%, ACROS Organics™ | Fisher ScientificCatechol, 99+%, ACROS Organics™ | Fisher Scientific
Solubility in water: 430g/L (20°C). Other solubilities: soluble in alcohol, benzene, chloroform, ether, and pyridine and aqueous solutions ...
https://www.fishersci.ca/shop/products/catechol-99-acros-organics-4/AC158980100
Catechol (C6H6O2) | RMICatechol (C6H6O2) | RMI
Raw Material India (RMI) is a new startup - an online platform Only For Industrial Raw Materials of all types. This is Indias First-Of-Its-Kind Exclusive B2B Raw Materials website.. ...
https://rawmaterialsindia.in/category/chemicals/7932/catechol-c6h6o2
KAKEN - Researchers | NOZAKI Mitsuhiro (00025545)KAKEN - Researchers | NOZAKI Mitsuhiro (00025545)
Affiliation：Professor,Shiga University of Medical Science,医学部,教授, Research Field：General medical chemistry, Keywords：カテコ-ル2,3ー二原子酸素添加酵素,酸素添加酵素,日中間学術交流,Oxygenase,Catechol 2, 3-dioxygenase,生体代謝調節,2, 3-dioxygenase,3, 5-dichlorocatechol,アミノ酸配列,Charge transfer complex, # of Research Projects：5, # of Research Products：0
https://nrid.nii.ac.jp/nrid/1000000025545/
Entacapone Teva - information til sundhedsfaglige - Medicin.dkEntacapone Teva - information til sundhedsfaglige - Medicin.dk
Pro.medicin.dk er en hjemmeside og database, der indeholder information om lægemidler og behandlingsvejledninger til læger, farmaceuter og andre sundhedsprofessionelle. Al information er skrevet på fagsprog. Vil du gerne læse information om medicin og behandling, der ikke er på fagsprog, så besøg min.medicin.dk. ...
http://pro.medicin.dk/Medicin/Praeparater/6944
L-DOPA biotransformation: Correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with...
TY - JOUR. T1 - L-DOPA biotransformation. T2 - Correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with metabolic pathways in Parkinsonian patients. AU - Dousa, M. K.. AU - Weinshilboum, Richard M. AU - Muenter, M. D.. AU - Offord, K. P.. AU - Decker, P. A.. AU - Tyce, G. M.. PY - 2003/8/1. Y1 - 2003/8/1. N2 - The objectives of this study were to determine (1) the effects of dose and drug absorption on pathways of biotransformation of L-DOPA in Parkinsonian patients treated with Sinemet, and (2) the extent to which genetically-determined variations in the activities of erythrocyte catechol O-methyltransferase and/or platelet phenol sulfotransferase might be reflected in individual differences in L-DOPA metabolism. In the 19 patients studied, there were negative correlations between dosage or absorption and extent of O-methylation and of sulfation of L-DOPA or its metabolites. Levels of activity for erythrocyte COMT were also reflected in individual ...
https://mayoclinic.pure.elsevier.com/en/publications/l-dopa-biotransformation-correlations-of-dosage-erythrocyte-catec
Plus itPlus it
Catechols are known to coordinate divalent metal ions by virtue of their acidic ortho-hydroxyl groups. A recent HTS screening campaign to develop inhibitors against Pfm18AAP, a potential drug target for the treatment of malaria, identified a number of catechol-containing inhibitory molecules (Schoenen et al., 2010). In fact, the best-in-class probe identified in that screen, ML369 (Supplemental Fig. 5A), features a catechol moiety linked to a piperidine-tetrahydroquinoline ring system. Catechols have also been identified as inhibitors of methionine aminopeptidase, which, like DNPEP, also contains a binuclear zinc center. A structure of E. coli methionine aminopeptidase in complex with a catechol-containing compound revealed the mode of interaction of the catechol ring with the binuclear zinc center (Wang et al., 2008). In this structure, one of the hydroxyl groups of the catechol replaced water as a bridging ligand, whereas the other interacted with one of the zinc ions enforced by the active ...
http://molpharm.aspetjournals.org/content/86/2/231
Catechol | definition of catechol by Medical dictionaryCatechol | definition of catechol by Medical dictionary
Looking for online definition of catechol in the Medical Dictionary? catechol explanation free. What is catechol? Meaning of catechol medical term. What does catechol mean?
https://medical-dictionary.thefreedictionary.com/catechol
Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons...Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons...
Natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11,13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. Minimum inhibitory activities of these diterpenes and previously synthesized natural diterpenes were measured against methicillin-resistant Staphylococcus aureus (MRSA) and Propionibacterium acnes, which cause serious skin infection associated with acne. Abietaquinone methide and 8,11,13-totaratriene-12,13-diol showed potent activities against S. aureus (MRSA) and P. acnes, and no serious toxicity by oral dose to mice.
https://www.semanticscholar.org/paper/Syntheses-and-antibacterial-activities-of-diterpen-Tada-Kurabe/68b51c14e61ec65d7b67c0c3dfa84899b32f5b63
EC 1.13.11.2EC 1.13.11.2
Accepted name: catechol 2,3-dioxygenase. Reaction: catechol + O2 = 2-hydroxymuconate-6-semialdehyde. For diagram of reaction click here.. Glossary: 2-hydroxymuconate-6-semialdehyde = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate. Other name(s): 2,3-pyrocatechase; catechol 2,3-oxygenase; catechol oxygenase; metapyrocatechase; pyrocatechol 2,3-dioxygenase; xylE (gene name). Systematic name: catechol:oxygen 2,3-oxidoreductase (decyclizing). Comments: Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 9029-46-3. References:. 1. Hayaishi, O. Direct oxygenation by O2, oxygenases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 8, Academic Press, New York, 1963, pp. 353-371.. 2. Kojima, Y., Itada, N. and Hayaishi, O. Metapyrocatechase: a new catechol-cleaving enzyme. J. Biol. Chem. 236 (1961) 2223-2228. [PMID: 13757654]. 3. Nozaki, M., Kagamiyama, H. ...
http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC1/13/11/2.html
Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dogIdentification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog
Metabolites of entacapone, (E)-2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl) propenamide, a potent inhibitor of catechol-O-methyltransferase, were isolated from dog urine. After hydrolysis of glucuronides and sulfates, 5 metabolites were identified in addition to unchanged entacapone by HPLC w …
https://pubmed.ncbi.nlm.nih.gov/8020535/?dopt=Abstract
Plus itPlus it
Conjugation of a structurally diverse set of 53 catechol compounds was studied in vitro using six recombinant human sulfotransferases (SULTs), five UDP-glucuronosyltransferases (UGT) and the soluble form of catechol O-methyltransferase (S-COMT) as catalyst. The catechol set comprised endogenous compounds, such as catecholamines and catecholestrogens, drugs, natural plant constituents, and other catechols with diverse substituent properties and substitution patterns. Most of the catechols studied were substrates of S-COMT and four SULT isoforms (1A1, 1A2, 1A3, and 1B1), but the rates of conjugation varied considerably, depending on the substrate structure and the enzyme form. SULT1E1 sulfated fewer catechols. Only low activities were observed for SULT1C2. UGT1A9 glucuronidated catechols representing various structural classes, and almost half of the studied compounds were glucuronidated at a high rate. The other UGT enzymes (1A1, 1A6, 2B7, and 2B15) showed narrower substrate specificity for ...
https://dmd.aspetjournals.org/content/31/9/1187
IJMS | Free Full-Text | Relation Between the Adsorbed Quantity and the Immersion Enthalpy in Catechol Aqueous Solutions on...IJMS | Free Full-Text | Relation Between the Adsorbed Quantity and the Immersion Enthalpy in Catechol Aqueous Solutions on...
An activated carbon, CarbochemTM-PS230, was modified by chemical and thermal treatment in flow of H2, in order to evaluate the influence of the activated carbon chemical characteristics in the adsorption of the catechol. The catechol adsorption in aqueous solution was studied along with the effect of the pH solution in the adsorption process of modified activated carbons and the variation of immersion enthalpy of activated carbons in the aqueous solutions of catechol. The interaction solid-solution is characterized by adsorption isotherms analysis, at 298 K and pH 7, 9 and 11 in order to evaluate the adsorption value above and below that of the catechol pKa. The adsorption capacity of carbons increases when the solution pH decreases. The retained amount increases slightly in the reduced carbon to maximum adsorption pH and diminishes in the oxidized carbon. Similar conclusions are obtained from the immersion enthalpies, whose values increase with the solute quantity retained. In granular activated carbon
http://www.mdpi.com/1422-0067/13/1/44
New Cures » cancer curing ginger
That said, it might. We did a little research…. Ginger Phytochemistry:. The chemical constituents of ginger (and ginger supplements) have been known for some years [2][3]. 6-shogaol is one of the 4 main pungent constituents of ginger [4] (the others are 6-gingerol, 8-gingerol and 10-gingerol. Shogaols are chemically similar to gingerols - being the dehydrated form thereof. Interestingly, Shogaols are found in only small quantities in the fresh root and are mainly found in the dried and thermally treated roots; with 6-shogaol becoming the most abundant of these constituents when ginger is dried or cooked. [5] There are smaller amounts of other gingerols, shogaols and many further compounds in ginger; these are largely untested but may contribute significantly to the health benefits of the whole root.. Bioavailability Of 6-Shogaol:. As it happens, a 2010 study has investigated the bioavailability of 6-shogaol. [4] Their notes reported first of all that prior to that study, few studies had ...
http://newcures.info/tag/cancer-curing-ginger/
ACPD - Biodegradation of phenol and catechol in cloud water: Comparison to chemical oxidation in the atmospheric multiphase...ACPD - Biodegradation of phenol and catechol in cloud water: Comparison to chemical oxidation in the atmospheric multiphase...
Abstract. The sinks of hydrocarbons in the atmosphere are usually described by oxidation reactions in the gas and aqueous (cloud) phases. Previous lab studies suggest that in addition to chemical processes, biodegradation by bacteria might also contribute to the loss of organics in clouds; however, due to the lack of comprehensive data sets on such biodegradation processes, they are not commonly included in atmospheric models. In the current study, we measured the biodegradation rates of phenol and catechol, which are known pollutants, by one of the most active strains selected during our previous screening in clouds (Rhodococcus enclensis). For catechol, biodegradation transformation is about ten times faster than for phenol. The experimentally derived biodegradation rates are included in a multiphase box model to compare the chemical loss rates of phenol and catechol in both the gas and aqueous phases to their biodegradation rate in the aqueous phase under atmospheric conditions. Model results ...
https://www.atmos-chem-phys-discuss.net/acp-2019-1048/
IJMS | Free Full-Text | The Metabolic Fate of ortho-Quinones Derived from Catecholamine MetabolitesIJMS | Free Full-Text | The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites
ortho-Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. Neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (DA) and norepinephrine (NE) via an interaction with cysteine, but it also incorporates their alcoholic and acidic metabolites. In this study we examined the metabolic fate of ortho-quinones derived from the catecholamine metabolites, 3,4-dihydroxyphenylethanol (DOPE), 3,4-dihydroxyphenylethylene glycol (DOPEG), 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylmandelic acid (DOMA). The oxidation of catecholic substrates by mushroom tyrosinase was followed by UV-visible spectrophotometry. HPLC analysis after reduction with NaBH4 or ascorbic acid enabled measurement of the half-lives of ortho-quinones and the identification of their reaction products. Spectrophotometric examination showed that the ortho-quinones initially formed
http://www.mdpi.com/1422-0067/17/2/164
인간진피섬유아세포에서 6-Shogaol의 세포보호 및 항염증 효과인간진피섬유아세포에서 6-Shogaol의 세포보호 및 항염증 효과
화장품 산업은 인류의 오랜 꿈 가운데 하나인 미(美)에 대한 욕망을 바탕으로 지금까지 꾸준히 발전해 왔다. 특히 21세기에 들어서 고령인구의 증가로 인한 소비자층의 확대와 환경, 화장품 원료의 안전성에 대한 관심 급증으로 인해 현재 노화예방 효능이 우수하면서도 안전한 천연 유래 화장품 원료 개발이 시급한 실정이다.. 6-Shogaol은 생강(Zingiber officinale)의 매운맛을 내게 해주는 주성분 중 하나로 신선한 생강에 가장 많이 들어있는 gingerols의 가수분해산물이다. 최근 6-shogaol이 gingerol보다 항염증, 항산화, 항암 효과가 더 뛰어나다는 연구보고가 잇따르고 있으나 이와 관련한 대부분의 연구는 식품이나 의·약학, 생명과학 분야에 국한되어 있다. 현재 향장 분야에서의 6-shogaol에 대한 연구는 극히 미미하며, 특히 인간진피섬유아세포에서의 6-shogaol에 대한 ...
http://e-ajbc.org/journal/view.php?viewtype=pubreader&number=1025
Entacapone Tablets, USP*Entacapone Tablets, USP*
Patients should be instructed to take entacapone tablets only as prescribed. Patients should be informed that hallucinations can occur. Patients should be advised that they may develop postural (orthostatic) hypotension with or without symptoms such as dizziness, nausea, syncope, and sweating. Hypotension may occur more frequently during initial therapy. Accordingly, patients should be cautioned against rising rapidly after sitting or lying down, especially if they have been doing so for prolonged periods, and especially at the initiation of treatment with entacapone tablets. Patients should be advised that they should neither drive a car nor operate other complex machinery until they have gained sufficient experience on entacapone tablets to gauge whether or not it affects their mental and/or motor performance adversely. Because of the possible additive sedative effects, caution should be used when patients are taking other CNS depressants in combination with entacapone tablets. Patients should ...
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=01ea62f4-bfac-485a-bb4b-a9abb345749f&type=display
What Is Pharmacology - Entacapone - MedicalrealmWhat Is Pharmacology - Entacapone - Medicalrealm
Entacapone is a catechol -o methyl trasnferase inhibitor. Entacapone is useful as an adjunct in patient currently on carbidopa and levodopa therapy. Entacapone will synergies the levodopa and carbidopa anti parkinsonian effects.
http://www.medicalrealm.net/what-is-pharmacology---entacapone.html
OSA | Quantitative Analysis of Entacapone Isomers Using Surface-Enhanced Raman Spectroscopy and Partial Least...OSA | Quantitative Analysis of Entacapone Isomers Using Surface-Enhanced Raman Spectroscopy and Partial Least...
Surface-enhanced Raman spectroscopy (SERS) and partial least squares (PLS) regression have been applied for the quantification of entacapone isomers ,i,E,/i, and ,i,Z,/i, in solution. Nine mixtures of isomers ,i,Z,/i, and ,i,E,/i, in ethanol ranging from 0% to 100% w/w were analyzed, for a total entacapone concentration of 1 × 10,sup,−3,/sup, mol L,sup,−1,/sup,. Upon deposition onto commercially available Klarite,b,®,/b, gold plates, highly intense and reproducible SERS spectra were obtained from the entacapone isomers. Based on the spectral measurements, a two-component PLS model for correlation of predicted and real content of the isomers mixtures was developed. Root-mean-square error of the predicted composition was found to be 8% of isomer ,i,Z,/i, in the isomers mixture, corresponding to the absolute concentration of 8 × 10,sup,−5,/sup, mol L,sup,−1,/sup, of isomer ,i,Z,/i, in solution.. PDF Article ...
https://www.osapublishing.org/vjbo/abstract.cfm?uri=as-66-12-1468
DNA degradation by the mixture of copper and catechol is caused by DNA-copper-hydroperoxo complexes, probably DNA-Cu(I)OOH |...DNA degradation by the mixture of copper and catechol is caused by DNA-copper-hydroperoxo complexes, probably DNA-Cu(I)OOH |...
Free hydroxyl radicals (free ·OH), singlet oxygen (1O2), or ·OH produced by DNA-copper-hydroperoxo complexes are possible DNA-damaging reactive oxygen species (ROS) in the reaction system containing copper, catechol, and DNA. para-Chlorobenzoic acid (pCBA) degradation studies revealed that CuCl2 mixed with catechol produced free ·OH. In the presence of DNA, however, inhibition of the pCBA degradation suggested that another ROS is responsible for the DNA degradation. Of a series of ROS scavengers investigated, only KI, NaN3, and Na-formate-all of the salts tested-strongly inhibited the DNA degradation, suggesting that the ionic strength rather than the reactivity of the individual scavengers could be responsible for the observed inhibition. The ionic strength effect was confirmed by increasing the concentration of phosphate buffer, which is a poor ·OH scavenger, and was interpreted as the result of destabilization of DNA-copper-hydroperoxo complexes. Piperidine-labile site patterns in DNA ...
https://www.dora.lib4ri.ch/eawag/islandora/object/eawag%3A4037
Metabolism of [6]-Shogaol in Mice and in Cancer Cells | Drug Metabolism & DispositionMetabolism of [6]-Shogaol in Mice and in Cancer Cells | Drug Metabolism & Disposition
The possible cancer-preventive activity of ginger is receiving a great deal of attention. Information on the metabolism of ginger components such as [6]-shogaol is important for understanding the biological effects of ginger. The mouse and cancer cells are frequently used as experimental models to study the cancer-preventive effects of ginger and its bioactive components. Our results indicate that [6]-shogaol is extensively metabolized in mice and in cancer cells. In the present study, 13 metabolites were identified, with 12 in mice and 4 in cancer cells (Fig. 1).. Reduction of xenobiotic carbonyls is a significant metabolic route to produce more hydrophilic and often less toxic compounds, which can be substrates for phase II conjugation by UDP-glucuronosyltransferases or sulfotransferases, leading ultimately to excretion of the products (Oppermann, 2007). In this investigation, reduced metabolites were formed in which M11 is the double-bond-reduced metabolite of [6]-shogaol, and M9 and M6 are ...
http://dmd.aspetjournals.org/content/40/4/742.full
A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder...
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https://www.win.ox.ac.uk/publications/98098
o- catechol methyltransferase inhibitors and their use in the treatment of psychiatric disorders | Semantic Scholaro- catechol methyltransferase inhibitors and their use in the treatment of psychiatric disorders | Semantic Scholar
The present invention relates to 4-pyridinone compound as catechol -O- methyltransferase (COMT) inhibitors and are useful in the treatment or prevention of COMT enzyme is involved in neurological and psychiatric disorders and diseases. The present invention also relates to the use of these compounds comprises pharmaceutical compositions of these compounds and compositions in the prevention or disease involving COMT treatment.
https://www.semanticscholar.org/paper/o-catechol-methyltransferase-inhibitors-and-their-J.%E6%A2%85%E6%8B%89%E6%A2%85%E5%BE%B7-S.%E6%B2%83%E5%B0%94%E8%82%AF%E4%BC%AF%E6%A0%BC/6b6dde3944645ad0dc65d92cc02a109cee3bfd8c
6]-Gingerol >= 98 % HPLC | 23513-14-6 | Sigma...6]-Gingerol >= 98 % HPLC | 23513-14-6 | Sigma...
[6]-Gingerol ≥98% (HPLC); CAS Number: 23513-14-6; Synonym: 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-, 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone, 6-Gingerol; Linear Formula: C17H26O4; find Sigma-Aldrich-G1046 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
https://www.sigmaaldrich.com/catalog/product/sigma/g1046?lang=en®ion=US
Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA - Fingerprint - UC Davis
Fingerprint Dive into the research topics of Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Together they form a unique fingerprint. ...
https://ucdavis.pure.elsevier.com/en/publications/cytochrome-p450-isoforms-catalyze-formation-of-catechol-estrogen-/fingerprints/
butyl carbitol sdsbutyl carbitol sds
Product Name: BUTYL CARBITOL(TM) SOLVENT Revision Date: 2011/03/29 Page 3 of 10 EC-No. Learn more about Diethylene glycol monobutyl ether. 4-tert-Butylcatechol (TBC) is an organic chemical compound which is a derivative of catechol. 203-961-6 FORMULA C4H9(OCH 2CH 2)2OH MOL WT. BUTYL CARBITOL PRODUCT IDENTIFICATION CAS NO. This SDS, and the associated product, is intended for use only by technically qualified persons, and at their own discretion and risk. We enable science by offering product choice, services, process excellence and our people make it happen. Donâ t use Butyl Cellosolve Butyl Cellosolve (CAS #111-76-2 also known as Butyl Cellusolve, Butoxyethanol, Butyl Glycol and Ethylene Glycol Monobutyl Ether) is a toxic agent used in many industrial and domestic cleaners â many of â ¦ Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. Butyl diglycol or Diethylene glycol mono butyl ether or Butyl carbitol Manufacturers, with SDS GHS MSDS Sheet Muby Chemicals of Mubychem Group, ...
https://www.myvirtualphonenumber.com/baby-pig-jzzcnp/4e44f6-butyl-carbitol-sds
Catechol ring-cleavage inPseudomonas cepacia: the simultaneous induction oforthoandmetapathways | SpringerLinkCatechol ring-cleavage inPseudomonas cepacia: the simultaneous induction oforthoandmetapathways | SpringerLink
This work demonstrates the ring-cleavage pathways of catechol on Pseudomonas cepacia ATCC 29351, formed upon its growth on salicylate and benzoate, each as a sole carbon source. When grown on salicyla
https://link.springer.com/article/10.1007%2FBF00186968
Non‐Carbohydrate Glycomimetics as Inhibitors of Calcium(II)‐binding Lectins - Centre de recherches sur les macromolécules...Non‐Carbohydrate Glycomimetics as Inhibitors of Calcium(II)‐binding Lectins - Centre de recherches sur les macromolécules...
Because of the antimicrobial resistance crisis, lectins are considered novel drug targets. Pseudomonas aeruginosa utilizes LecA and LecB in the infection process. Inhibition of both lectins with carbohydrate‐derived molecules can reduce biofilm formation to restore antimicrobial susceptibility. Here, we focused on non‐carbohydrate inhibitors for LecA to explore new avenues for lectin inhibition. From a screening cascade we obtained one experimentally confirmed hit, a catechol, belonging to the well‐known PAINS compounds. Rigorous analyses validated electron‐deficient catechols as millimolar LecA inhibitors. The first co‐crystal structure of a non‐carbohydrate inhibitor in complex with a bacterial lectin clearly demonstrates the catechol mimicking the binding of natural glycosides with LecA. Importantly, catechol 3 is the first non‐carbohydrate lectin ligand that binds bacterial and mammalian calcium(II)‐binding lectins, giving rise to this fundamentally new class of ...
https://cermav.grenoble.cnrs.fr/en/blog/actualite/non%E2%80%90carbohydrate-glycomimetics-as-inhibitors-of-calciumii%E2%80%90binding-lectins-2/
Catechol changes in the rat rostral ventrolateral medulla following changes in systemic CO2.
A catechol signal recorded with in vivo voltammetry within the rat rostral ventrolateral medulla (RVLM) was taken as an index of the activity of RVLM adrenergic neurons and related to the level of arterial PCO2, under halothane anesthesia. Reversible
http://www.biomedsearch.com/nih/Catechol-changes-in-rat-rostral/9321872.html
Carbolic acid-Phenol | Henriettes Herbal HomepageCarbolic acid-Phenol | Henriettes Herbal Homepage
Resorcinum, Resorcin, (Meta-dioxy-benzol), C6H4(OH)2-is a diatomic phenol, and one of the three isomeric substances formed by substituting two atoms of hydroxyl for two of hydrogen in Benzene (Benzol), as the substitution of one produces Carbolic Acid. The relative positions of the hydroxyl atoms in the ring are for Resorcin 1 and 3, for Pyrocatechin 1 and 2, and for Hydroquinone 1 and 4, the two latter having the respective prefixes Ortho, and Para, with the composition name Dioxy-benzol, and the same formula as the first. Resorcin occurs in colorless, rhombic Prisms or plates of neutral reaction, soluble in water, also in alcohol, ether, etc. Dose, gr. v-xv; as an antipyretic ʒss-j not repeated for several hours, or gr. v every 2 hours.. *Hydroquinone occurs in plates of sweetish taste, and is about four times stronger than Resorcin, having the same action and uses.. *Pyrocatechin also occurs in plates or crystals, is three times stronger than Resorcin, but otherwise the same; is ...
https://www.henriettes-herb.com/eclectic/potter-comp/carbolic-acid.html
Complexation of Zn(II) by catechol in hydroxylic solventsComplexation of Zn(II) by catechol in hydroxylic solvents
The stability of the complex formed by one molecule of 1,2-dihydroxybenzene and one molecule of zinc acetate in solutions with different permittivity and temperature was investigated by means of spectroscopic and chromatographic methods. The Becke hybrid three-parameter nonlocal exchange functional combined with the Lee-Yang-Parr dynamic correlation functional method (B3LYP/6-31G(d)) and the isodensity polarized continuum model (IPCM) were used in the calculations. It was assumed that the formation of the complex takes place by a reaction between ions of opposite charges. It was also proposed an equation to explain the changes of the constant of the complexation equilibrium with the permittivity of the reaction medium. The calculations allowed us to prove that the increase of the hydrogen-bond donor ability of the solvents favours a higher thermodynamic stability of the reactants with respect to the complex and, as a result, a decrease of the corresponding equilibrium constants. The non-planar ...
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0365-03752006000100012&lng=es&nrm=iso
US 8492367 B2 - Use Of 2,5-dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea - The LensUS 8492367 B2 - Use Of 2,5-dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea - The Lens
The Lens serves nearly all of the patents in the world as open, annotatable digital public goods that are integrated with scholarly and technical literature along with regulatory and business data.
https://www.lens.org/lens/patent/US_8492367_B2/fulltext
US 2013/0296282 A1 - Methods Of Use For 2,5-dihydroxybenzene Sulfonic Acid Compounds For The Treatment Of Cancer, Rosacea And...US 2013/0296282 A1 - Methods Of Use For 2,5-dihydroxybenzene Sulfonic Acid Compounds For The Treatment Of Cancer, Rosacea And...
The Lens serves nearly all of the patent documents in the world as open, annotatable digital public goods that are integrated with scholarly and technical literature along with regulatory and business data.
https://www.lens.org/lens/patent/US_2013_0296282_A1/fulltext
Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric...Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric...
When (6)-shogaol (0.5 mg/kg, i.v.) was administered to rats, blood pressure showed a tri-phasic response which was comprised of a rapid fall, followed by a rise and a delayed fall. The rapid fall, which followed immediately after injection of (6)-shogaol, disappeared with the use of atropine and vag …
https://pubmed.ncbi.nlm.nih.gov/3820061/?dopt=Abstract
Effects of hispolon on glioblastoma cell growth. - PubMed - NCBIEffects of hispolon on glioblastoma cell growth. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/28618133
KEGG Metagenome: T31030KEGG Metagenome: T31030
Xenobiotics biodegradation Aromatics degradation M00569 Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:T31030_00362 T31030_00622 T31030_01220 T31030_01100 T31030_01120 ...
https://www.kegg.jp/kegg-bin/show_organism?menu_type=pathway_modules&org=T31030
strain RP007-rif Strain Passport - StrainInfo
Burkholderia sp. RP007 aromatic 1,2-dioxygenase beta subunit (phnY),chloroplast-type ferredoxin (phnT2), catechol 2,3-dioxygenase (phnE2), and(phnX) genes, complete cds; and 2-hydroxymuconic semialdehyde dehydrogenase(phnG2) gene, partial ...
http://www.straininfo.net/strains/839296
Inhibition of soluble catechol- O -methyltransferase and single-dose pharmacokinetics after oral and intravenous administration...Inhibition of soluble catechol- O -methyltransferase and single-dose pharmacokinetics after oral and intravenous administration...
The inhibition of soluble catechol-O-methyltransferase (S-COMT) in red blood cells (RBCs) by entacapone, and the pharmacokinetics of entacapone after singl
https://rd.springer.com/article/10.1007%2FBF00199880
GMD - 2OXOVALERATE, TBS 1X, METHOXIM 2GMD - 2OXOVALERATE, TBS 1X, METHOXIM 2
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
http://gmd.mpimp-golm.mpg.de/Analytes/C88E879B-9556-4C90-83D7-7653DFECD344.aspx
GMD - 2OXOVALERATE, TBS 2X (ENOL2)GMD - 2OXOVALERATE, TBS 2X (ENOL2)
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
http://gmd.mpimp-golm.mpg.de/Analytes/3BE4564B-6C74-4BA9-B705-E85F6C70BEED.aspx
Decarboxylation of 2,3-dihydroxybenzoate to catechol supports growth of fermenting bacteriaDecarboxylation of 2,3-dihydroxybenzoate to catechol supports growth of fermenting bacteria
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https://kops.uni-konstanz.de/handle/123456789/8127
ETIS - Grouping of phenol hydroxylase and catechol 2,3-dioxygenase genes among phenol- and p-cresol-degrading Pseudomonas...
Eesti Teadusinfosüsteem koondab informatsiooni teadus- ja arendusasutuste, teadlaste, teadusprojektide ning erinevate teadustegevuste tulemuste kohta.
https://www.etis.ee/Portal/Publications/Display/a22655f7-b889-43a4-8fb4-9a1a52e5b965
JoVE Search Results: Catechol 1%2C2 Dioxygenase
Gene, Gene Expression, Disease, Human, Cell, Retinal, Vision, 11-cis-retinal, Eyes, Mice, Polymer, Lead, Ionic Liquids, Viscosity, and Contracts
http://labindex.jove.com/group/Catechol-1%2C2-Dioxygenase
Reverse-phase chromatography of polar biological substances: separation of catechol compounds by high-performance liquid...Reverse-phase chromatography of polar biological substances: separation of catechol compounds by high-performance liquid...
Catecholamines and their metabolites have been separated isocratically by reverse-phase chromatography with aqueous (no organic solvent admixed) eluents. Unlike ion-exchange or ion-pair chromatography, mixtures of both acidic and basic substances can be separated in a single chromatographic run, because the retention is governed by hydrophobic interactions between the nonpolar moiety of the solute molecules and the octadecyl-silica stationary phase. The relative retention values strongly depend on the pH of the eluent, which governs the degree of dissociation of ionogenic solutes. The reproducibility of the results and the stability and efficiency of the chromatographic systems make this approach particularly attractive for use in clinical analysis.. ...
http://clinchem.aaccjnls.org/content/22/9/1497.short
Bioactive flavonoids and catechols as Hif1 and Nrf2 protein stabilizers - implications for Parkinsons disease - Fingerprint ...
Natalya A. Smirnova, Navneet Ammal Kaidery, Dmitry M. Hushpulian, Ilay I. Rakhman, Andrey A. Poloznikov, Vladimir I. Tishkov, Saravanan S. Karuppagounder, Irina N. Gaisina, Anton Pekcec, Klaus Van Leyen, Sergey V. Kazakov, Lichuan Yang, Bobby Thomas, Rajiv R. Ratan, Irina G. Gazaryan ...
https://augusta.pure.elsevier.com/en/publications/bioactive-flavonoids-and-catechols-as-hif1-and-nrf2-protein-stabi/fingerprints/
Plus itPlus it
Rabbits made tolerant to narcotic and lethal doses of l-norepinephrine (3.2 mg/kg intravenous) were infused with dl-norepinephrine-H3 at a rate of 50 µc/kg min-1 for 20 minutes. Concentrations of norepinephrine-H3 in plasma obtained during infusion and for 40 minutes thereafter were similar for the tolerant group, controls and a group treated 24 hours earlier with reserpine (1 mg/kg). Except for reduced concentrations in the heart, uptake of norepinephrine-H3 in organs of tolerant animals was found similar to the controls. In the groups treated with reserpine, norepinephrine-H3 binding was less in all organs but the kidney.. Only about half the normal catechol concentrations were found in hearts of tolerant animals, yet both spleen and kidney were found to contain several times the control amount. Although reserpine markedly diminished the catechol content of the heart, no significant decrease occurred in spleen or kidney.. Mean concentrations of unchanged norepinephrine-H3 in the urines of ...
https://jpet.aspetjournals.org/content/142/3/306
Dynamic experimental methods using in-situ measurements of the surface intermediates applied to the fine chemistry - InfoscienceDynamic experimental methods using in-situ measurements of the surface intermediates applied to the fine chemistry - Infoscience
Nonsteady-state kinetics was used for the detn. of the reaction mechanism of a heterogeneous catalytic reaction, and the characteristic shape of the time evolution curves of the concns. at the outlet of the reactor was assocd. with rate-limiting steps. Addnl. in-situ measurements of surface intermediates were correlated with those response curves to get a phys. meaning to the detd. kinetic parameters. An exptl. setup was developed to investigate simultaneously the surface and gas-phase concns. That the knowledge of the reaction mechanism and the identification of the active sites on the catalyst are of great use for reaction engineering was exemplified with the methylation of catechol where the catalyst was selectively modified to increase the yield of 3-methylcatechol from 25 to nearly 70%. [on SciFinder (R)] Doepper, Ralf; Renken, Albert
https://infoscience.epfl.ch/record/84329
Search ResultsSearch Results
You may also wish to search for items by Ribeiro da Silva, M.A., Ribeiro da Silva, M. and Ribeiro da Silva. 92 matching references were found. Cavell, K.J.; Connor, J.A.; Pilcher, G.; Ribeiro da Silva, M.A.V.; Ribiero da Silva, D.M.C.; Vipmani, Y.; Zafarani-Moattar, M.T., J. Chem. Soc. Faraday Trans. 1, 1981, 77, 1585. [all data] Ferrao, M.L.C.C.H.; Ribeiro Da Silva, M.A.V., Enthalpies of combustion of four methyl-substituted heptane-3,5-diones and benzoylacetone, J. Chem. Thermodyn., 1981, 13, 567-571. [all data] Ribeiro Da Silva, M.A.V., Thermochemistry of «beta»-diketones and metal «beta»-diketonates, NATO ASI Ser., Ser. C, 1984, 119, 317-338. [all data] Ribeiro Da Silva, M.D.M.C.; Ribeiro Da Silva, M.A.V., Enthalpies of combustion of 1,2-dihydroxybenzene and of six alkylsubstituted 1,2-dihydroxybenzenes, J. Chem. Thermodyn., 1984, 16, 1149-1155. [all data] Ribeiro da Silva, M.A.V.; Ribeiro da Silva, M.D.M.C.; Pilcher, G., The construction, calibration and use of a new high-precision ...
https://webbook.nist.gov/cgi/cbook.cgi?Author=Ribeiro+da+Silva%2C+M.A.V.&Units=CAL&Mask=4
Gingerol | GreenMedInfo | Substance | Natural Medicine | Alternative
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
https://www.greenmedinfo.health/substance/gingerol
6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion...6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion...
Sigma-Aldrich offers abstracts and full-text articles by [Ya-Ling Hsu, Jen-Yu Hung, Ying-Ming Tsai, Eing-Mei Tsai, Ming-Shyan Huang, Ming-Feng Hou, Po-Lin Kuo].
https://www.sigmaaldrich.com/catalog/papers/25621970
4-Shogaol | GreenMedInfo | Substance | Natural Medicine | Alternative4-Shogaol | GreenMedInfo | Substance | Natural Medicine | Alternative
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
https://www.greenmedinfo.com/substance/4-shogaol
Buy Δετίο Του Ιστορικού Και Πααιογραφικού Αρχείου Θ 2000Buy Δετίο Του Ιστορικού Και Πααιογραφικού Αρχείου Θ 2000
Zhang buy, Kimura Y, Jiang S, Harada K, Yamashita Y, iron. 2014) Luteolin produces word of persuading empires through the AhR and Nrf2 volunteers in -hydroxybiphenyl catechols. Arch BiochemBiophys 557: 36- 46.
http://opticasoftware.com/icyt/library.php?q=buy-%CE%B4%CE%B5%CF%84%CE%AF%CE%BF-%CF%84%CE%BF%CF%85-%CE%B9%CF%83%CF%84%CE%BF%CF%81%CE%B9%CE%BA%CE%BF%CF%8D-%CE%BA%CE%B1%CE%B9-%CF%80%CE%B1%CE%B1%CE%B9%CE%BF%CE%B3%CF%81%CE%B1%CF%86%CE%B9%CE%BA%CE%BF%CF%8D-%CE%B1%CF%81%CF%87%CE%B5%CE%AF%CE%BF%CF%85-%CE%B8-2000/
CatecholCatechol
... catechol was listed as pyrocatechol. In 1879, the Journal of the Chemical Society recommended that catechol be called "catechol ... Catechol occurs as feathery white crystals that are very rapidly soluble in water. Catechol was first isolated in 1839 by Edgar ... Iron-containing dioxygenase enzymes catalyze the cleavage of catechol. Catechols convert to the semiquinone radical. At pH = 7 ... Catechol has since been shown to occur in free form naturally in kino and in beechwood tar. Its sulfonic acid has been detected ...
https://en.wikipedia.org/wiki/Catechol
Catechol estrogenCatechol estrogen
A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in ... Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and ...
https://en.wikipedia.org/wiki/Catechol_estrogen
Catechol oxidaseCatechol oxidase
In plants, catechol oxidase plays a key role in enzymatic browning by catalyzing the oxidation of catechol to o-quinone in the ... As catechol enters the active site, a proton is abstracted from one of the alcohols. The catechol coordinates with a Cu(II) ... The coordinated hydroxide ion abstracts another proton from catechol to form water, and the catechol is oxidized to o-quinone. ... In this state, the enzyme active site is in a ternary catechol oxidase-O22−-catechol complex. Two electrons are transferred ...
https://en.wikipedia.org/wiki/Catechol_oxidase
Catechol dioxygenaseCatechol dioxygenase
... s are metalloprotein enzymes that carry out the oxidative cleavage of catechols. This class of enzymes ... An example of the reaction carried out by catechol 1,2-dioxygenase is the formation of cis,cis-muconic acid from catechol, ... catechol 2,3-dioxygenase (EC 1.13.11.2), and protocatechuate 3,4-dioxygenase (EC 1.13.11.3). The active site of catechol ... The Pseudomonas putida xylE gene, which encodes catechol 2,3-dioxygenase, is often used as a reporter to quantitate gene ...
https://en.wikipedia.org/wiki/Catechol_dioxygenase
Catechol oxidase (dimerizing)Catechol oxidase (dimerizing)
In enzymology, a catechol oxidase (dimerizing) (EC 1.1.3.14) is an enzyme that catalyzes the chemical reaction 4 catechol + 3 ... The systematic name of this enzyme class is catechol:oxygen oxidoreductase (dimerizing). Nair PM, Vining LC (July 1964). " ... the two substrates of this enzyme are catechol and O2, whereas its two products are [[dibenzo[1,4]dioxin-2,3-dione]] and H2O. ... "Enzymic oxidation of catechol to diphenylenedioxide-2,3-quinone". Archives of Biochemistry and Biophysics. 106: 422-7. doi: ...
https://en.wikipedia.org/wiki/Catechol_oxidase_(dimerizing)
Chloridazon-catechol dioxygenaseChloridazon-catechol dioxygenase
... (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-(2,3- ... Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986". Eur. J. Biochem. 125 (3): 579-84. doi:10.1111/j. ... Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl ...
https://en.wikipedia.org/wiki/Chloridazon-catechol_dioxygenase
Catechol-O-methyltransferaseCatechol-O-methyltransferase
Wikimedia Commons has media related to Catechol O-methyltransferase, COMT. Catechol+O-Methyltransferase at the US National ... and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the ... Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. ... December 2008). "The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life". ...
https://en.wikipedia.org/wiki/Catechol-O-methyltransferase
Catechol-O-methyltransferase inhibitorCatechol-O-methyltransferase inhibitor
A catechol-O-methyltransferase (COMT) inhibitor is a drug that inhibits the enzyme catechol-O-methyltransferase. This enzyme ... Catechol-O-methyltransferase inhibitors, All stub articles, Nervous system drug stubs). ... "Identification of novel flavonoid inhibitor of Catechol-O-Methyltransferase enzyme by molecular screening, quantum mechanics/ ... diarrhea drowsiness urine discoloration dyskinesia Medication Management of Parkinson's disease catechol-O-methyltransferase ...
https://en.wikipedia.org/wiki/Catechol-O-methyltransferase_inhibitor
Catechol 1,2-dioxygenaseCatechol 1,2-dioxygenase
Catechol 1,2- dioxygenase (EC 1.13.11.1, 1,2-CTD, catechol-oxygen 1,2-oxidoreductase, 1,2-pyrocatechase, catechase, catechol 1, ... Pascal RA, Huang DS (July 1986). "Reactions of 3-ethylcatechol and 3-(methylthio)catechol with catechol dioxygenases". Archives ... 2-dioxygenase and catechol 2,3-dioxygenase (2,3-CTD). The two enzymes were identified to be a part of two separate catechol ... a family of catechol dioxygenases that cleaves the bond between the phenolic hydroxyl groups of catechol using an Fe3+ cofactor ...
https://en.wikipedia.org/wiki/Catechol_1,2-dioxygenase
Catechol 2,3-dioxygenaseCatechol 2,3-dioxygenase
... (EC 1.13.11.2, 2,3-pyrocatechase, catechol 2,3-oxygenase, catechol oxygenase, metapyrocatechase, ... Catechol+2,3-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: long ... Kojima Y, Itada N, Hayaishi O (August 1961). "Metapyrocatachase: a new catechol-cleaving enzyme". The Journal of Biological ... pyrocatechol 2,3-dioxygenase) is an enzyme with systematic name catechol:oxygen 2,3-oxidoreductase (decyclizing). This enzyme ...
https://en.wikipedia.org/wiki/Catechol_2,3-dioxygenase
PiperonalPiperonal
... can be prepared by the oxidative cleavage of isosafrole or by using a multistep sequence from catechol or 1,2- ... Synthesis from catechol requires an additional step, Williamson ether synthesis using dichloromethane. Piperonal, like all ... doi:10.1016/S0040-4039(00)88578-0. Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the ...
https://en.wikipedia.org/wiki/Piperonal
1,3-Benzodioxole1,3-Benzodioxole
doi:10.2174/1389200003339270 Bonthrone, W. & Cornforth, J. (1969). "The methylenation of catechols". Journal of the Chemical ... 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes. 1,4-Benzodioxine MDMA Methylenedioxy Safrole ...
https://en.wikipedia.org/wiki/1,3-Benzodioxole
Dakin oxidationDakin oxidation
Catechol, for example, is synthesized from o-hydroxy and o-alkoxy phenyl aldehydes and ketones, and is used as the starting ... Bora, Porag; Bora, Bondana; Bora, Utpal (2021). "Recent developments in synthesis of catechols by Dakin oxidation". New Journal ... Dakin, H.D. (1923). "Catechol". Organic Syntheses. 3: 28. doi:10.15227/orgsyn.003.0028. Surrey, Alexander R. (1946). " ...
https://en.wikipedia.org/wiki/Dakin_oxidation
SalicylaldehydeSalicylaldehyde
Dakin, H. D. (1923). "Catechol" (PDF). Organic Syntheses. 3: 28.; Collective Volume, vol. 1, p. 149 Burgstahler, A. W.; Worden ... Salicylaldehyde is used to make the following: Oxidation with hydrogen peroxide gives catechol (1,2-dihydroxybenzene) (Dakin ...
https://en.wikipedia.org/wiki/Salicylaldehyde
2-Hydroxyestrone2-Hydroxyestrone
... (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol ... Okatani Y, Fishman J (July 1986). "Inhibition of the preovulatory prolactin surge in the rat by catechol estrogens: functional ... 2-OHE1 is the most abundant catechol estrogen in the body. 2-Hydroxyestrone is not significantly uterotrophic in bioassays, ... When incubated at very high concentrations or in combination with a catechol O-methyltransferase (COMT) inhibitor to prevent ...
https://en.wikipedia.org/wiki/2-Hydroxyestrone
History of catecholamine researchHistory of catecholamine research
In the case the catecholamines, however, the enzymes of degradation monoamine oxidase and catechol-O-methyl transferase, like ... In this respect, ″amino-ethanol-catechol″ - noradrenaline - mimicked sympathetic nerves more closely than adrenaline did. The ... Julius Axelrod (1962). "O-Methylation of epinephrine and other catechols". Science. 126 (3270): 400-401. doi:10.1126/science. ... noradrenaline and adrenaline were O-methylated by catechol-O-methyl transferase. To fill the gap completely, however, the role ...
https://en.wikipedia.org/wiki/History_of_catecholamine_research
MethyltransferaseMethyltransferase
Catechol-O-methyltransferase (COMT) degrades a class of molecules known as catcholamines that includes dopamine, epinephrine, ... "COMT catechol-O-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. Ragsdale, S.W. "Catalysis of ... Examples include: Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate- ...
https://en.wikipedia.org/wiki/Methyltransferase
Benzoate degradation via hydroxylationBenzoate degradation via hydroxylation
Aerobic degradation forms catechol. Anaerobic degradation forms cyclohex-1,5-diene-1-carbonylCoA. A hybrid degradation forms ...
https://en.wikipedia.org/wiki/Benzoate_degradation_via_hydroxylation
SiderocalinSiderocalin
... allowing siderocalin to bind to the iron-catechol complex. Catechols can be bound by siderocalin, in the form of free ligands, ... Mammalian siderophores, specifically catechols, can be found in the human gut and in siderophores, such as enterobactin, and ... Catechol resembling molecules can act as iron ligands in the cell and in systematic circulation, ... Rogers HJ (Mar 1973). "Iron-Binding Catechols and Virulence in Escherichia coli". Infection and Immunity. 7 (3): 445-56. doi: ...
https://en.wikipedia.org/wiki/Siderocalin
PropoxurPropoxur
It is produced from catechol. Several U.S. states have petitioned the Environmental Protection Agency (EPA) to use propoxur ... Catechol ethers, Isopropyl compounds, Aromatic carbamates, Phenol esters). ...
https://en.wikipedia.org/wiki/Propoxur
SiderophoreSiderophore
... the catechol-type siderophores, agrobactin; and the mixed ligand catechol-hydroxamate-hydroxy acid siderophores biosynthesized ...
https://en.wikipedia.org/wiki/Siderophore
Polyphenol oxidasePolyphenol oxidase
... catechol oxidases). The substrate preference of tyrosinases and catechol oxidases is controlled by the amino acids around the ... A mixture of monophenol oxidase and catechol oxidase enzymes is present in nearly all plant tissues, and can also be found in ... A monomeric catechol oxidase from Populus nigra converts caffeic acid to quinone and melanine at injured cells. ... Panis F, Kampatsikas I, Bijelic A, Rompel A (February 2020). "Conversion of walnut tyrosinase into a catechol oxidase by site ...
https://en.wikipedia.org/wiki/Polyphenol_oxidase
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Kobayashi S, Hayaishi O (1970). "Anthranilic acid conversion to catechol (Pseudomonas)". Methods Enzymol. 17A: 505-510. doi: ... catechol + CO2 + NAD(P)+ + NH3 The 5 substrates of this enzyme are anthranilate, NADH, NADPH, H+, and O2, whereas its 5 ... "Enzymatic formation of catechol from anthranilic acid". J. Biol. Chem. 239: 2204-2211. PMID 14209949. Portal: Biology v t e ( ... products are catechol, CO2, NAD+, NADP+, and NH3. This enzyme belongs to the family of oxidoreductases, specifically those ...
https://en.wikipedia.org/wiki/Anthranilate_1,2-dioxygenase_(deaminating,_decarboxylating)
Muconolactone Δ-isomeraseMuconolactone Δ-isomerase
Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes ... Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A ... of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. PMID 5330966. ...
https://en.wikipedia.org/wiki/Muconolactone_Δ-isomerase
Muconate lactonizing enzymeMuconate lactonizing enzyme
... catechol branch and 2) protocatechuate branch. Catechol branch consists of cis, cis- muconate lactonizing enzyme, whereas a ... 3. Enzymes of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. doi:10.1016/S0021-9258(18)99841-8. ... Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. ... Ornston, L.N. (1970). Conversion of catechol and protocatechuate to β-ketoadipate (Pseudomonas putida). Methods Enzymol. ...
https://en.wikipedia.org/wiki/Muconate_lactonizing_enzyme
3-O-Methyldopa3-O-Methyldopa
... is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for ... 3-O-methyldopa is a major metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) and is formed by catechol-O-methyltransferase ( ... This process is catalyzed by catechol O-methyltransferase methylates (COMT). The action of the enzyme makes it possible the ... Tai, C. H.; Wu, R. M. (2002). "Catechol-O-methyltransferase and Parkinson's disease". Acta Medica Okayama. 56 (1): 1-6. PMID ...
https://en.wikipedia.org/wiki/3-O-Methyldopa
Fjodor LishajkoFjodor Lishajko
Euler, U. S. V.; Lishajko, F. (1959). "The Estimation of Catechol Amines in Urine". Acta Physiologica Scandinavica. 45 (2-3): ... Euler, U. S. Von; Lishajko, F. (1959). "Excretion of Catechol in Human Urine". Nature. 183 (4668): 1123-1123. doi:10.1038/ ...
https://en.wikipedia.org/wiki/Fjodor_Lishajko
4-carboxymuconolactone decarboxylase4-carboxymuconolactone decarboxylase
Ornston LN (August 1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes ... Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A ... of the catechol pathway". The Journal of Biological Chemistry. 241 (16): 3795-9. PMID 5330966. ...
https://en.wikipedia.org/wiki/4-carboxymuconolactone_decarboxylase
SclerotizationSclerotization
... which convert the catechol groups to quinones. The resulting quinones are susceptible to nucleophilic attack by amines and ... "Oxidative Conjugation of Catechols with Proteins in Insect Skeletal Systems". Tetrahedron. 57 (2): 385-392. doi:10.1016/S0040- ...
https://en.wikipedia.org/wiki/Sclerotization
RhododendrolRhododendrol
These phenols and catechols together form ortho-quinones (o-quinones). Presence of o-quinones can lead to cytotoxicity via the ... First, RD is catalysed by tyrosinase to produce toxic metabolites as RD-cyclic catechol. These reactive metabolites cause ... After oxidation of rhododendrol by the tyrosinase enzyme, several kinds of phenols and catechols are formed. ...
https://en.wikipedia.org/wiki/Rhododendrol
CDC - NIOSH Pocket Guide to Chemical Hazards - CatecholCDC - NIOSH Pocket Guide to Chemical Hazards - Catechol
1,2-Benzenediol, o-Benzenediol, 1,2-Dihydroxybenzene, o-Dihydroxybenzene, 2-Hydroxyphenol, Pyrocatechol Colorless, crystalline solid with a faint odor. [Note: Discolors to brown in air & light.]
https://www.cdc.gov/niosh/npg/npgd0109.html
Browsing by Subject CatecholsBrowsing by Subject "Catechols"
Sodeman, Thomas M; Contacos, Peter G; Collins, William E; Smith, Clinton S; Jumper, John R; World Health Organization (‎World Health OrganizationWorld Health Organization, 1972)‎ ...
https://extranet.who.int/iris/restricted/browse?authority=Catechols&type=mesh
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferaseMethylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
... have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O- ... Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase ... The full functional implications of pharmacogenetic variation in the activities of catechol O-methyltransferase and histamine N ... have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O- ...
https://pubmed.ncbi.nlm.nih.gov/10331075/?dopt=Abstract
Catechol O-methyltransferase (chicken) | Protein Target - PubChemCatechol O-methyltransferase (chicken) | Protein Target - PubChem
Protein target information for Catechol O-methyltransferase (chicken). Find diseases associated with this biological target and ...
https://pubchem.ncbi.nlm.nih.gov/protein/A0A1D5PBR8
Green Tea Extract and Catechol-O-Methyltransferase Genotype ModifyGreen Tea Extract and Catechol-O-Methyltransferase Genotype Modify
... Fasting Serum Insulin and Plasma Adiponectin Concentrations ... stratified by catechol-O-methyltransferase (COMT) genotype. This study was conducted in a subset of 237 overweight and obese ...
https://greenmedinfo.com/article/green-tea-extract-decreased-fasting-insulin-concentrations-those-elevated-base
Sciencemadness Discussion Board - Catechol preparation - Powered by XMB 1.9.11Sciencemadness Discussion Board - Catechol preparation - Powered by XMB 1.9.11
Catechol preparation. I have been interested in preparing Benzene-1,2-diol (catechol) for some time. Heres the route of ... Phenol -, Salicylaldehyde - , Catechol. Maybe someone could post the full paper. One-pot synthesis of substituted catechols ... attack a condenser to the flask, and heat to 240°C(bp of catechol) and keep on this temperature until no more catechol is ... Catechol (pyrocatechol). Organic Syntheses, Coll. Vol. 1, p.149 (1941); Vol. 3, p.28 (1923).. To a solution of 122 g. (1 mole) ...
http://www.sciencemadness.org/talk/viewthread.php?tid=293#pid129847
Catechol O-MethyltransferaseCatechol O-Methyltransferase
Lesnoi Vestn. strategy in different methods, like the synthesis of ureas composed of an all natural fragment, particularly, bicyclo[2.2.1]hept-5-ene-2-yl (norbornene), within the structures of materials within sandalwood resin [11], pine. ...
http://www.hwupdate.org/category/catechol-o-methyltransferase/
Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk1 | Cancer Epidemiology, Biomarkers & Prevention | American...Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk1 | Cancer Epidemiology, Biomarkers & Prevention | American...
Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk1 Katja Mitrunen; Katja Mitrunen ... Millikan R. C., Pittman G. S., Tse C. K. J., Duell E., Newman B., Savitz D., Moorman P. G., Boissy R. J., Bell D. A. Catechol-O ... Li T., Vallada H., Curtis D., Arranz M., Xu K., Cai G., Deng H., Liu J., Murray R., Liu X., Collier D. A. Catechol-O- ... Lachman H. M., Papolos D. F., Saito T., Yu Y-M., Szumlanski C. L., Weinshilboum R. M. Human catechol-O-methyltransferase ...
https://aacrjournals.org/cebp/article/10/6/635/164866/Polymorphic-Catechol-O-methyltransferase-Gene-and
Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate |...Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate |...
Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate. Hong ... Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate. Hong ... Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate. Hong ... Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate ...
https://dmd.aspetjournals.org/content/31/5/572/tab-article-info
Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype<...
Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. British Journal ... Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. In: British ... Dive into the research topics of Aggressive behaviour in patients with schizophrenia is associated with catechol-O- ... Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. / Jones, G.; ...
https://mayoclinic.pure.elsevier.com/en/publications/aggressive-behaviour-in-patients-with-schizophrenia-is-associated
Direct Evidence of Chelated Geometry of Catechol on TiO<sub>2</sub> by a Combined Solid-State NMR and DFT...
Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides. This ... N2 - Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides. This ... AB - Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides. This ... abstract = "Catechol on TiO2 is a model system for a class of molecules that bind and interact very strongly with metal oxides ...
https://asu.pure.elsevier.com/en/publications/direct-evidence-of-chelated-geometry-of-catechol-on-tiosub2sub-by
167 Supramolecular M 4 L 4 tetrahedra based on triangular acylhydrazone catechol ligands • Schalley Group • Department of...167 Supramolecular M 4 L 4 tetrahedra based on triangular acylhydrazone catechol ligands • Schalley Group • Department of...
Supramolecular M4L4 tetrahedra based on triangular acylhydrazone catechol ligands. M. Albrecht, Y. Shang, T. Rhyssen, J. ... p,167,/p,,p,Supramolecular M,sub,4,/sub,L,sub,4,/sub, tetrahedra based on triangular acylhydrazone catechol ligands,/p, ... Supramolecular M4L4 tetrahedra based on triangular acylhydrazone catechol ligands ...
https://www.bcp.fu-berlin.de/en/chemie/chemie/forschung/OrgChem/schalley/Publications/Pub167/index.html
1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action...1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action...
1-hydroxy-2(1H)-pyridinone, catechol O-methyl transferase, Parkinsons disease. Subjects:. C700 Molecular Biology, Biophysics ... 1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action ... they are designed to be inhibitors of catechol O-methyl transferase, which contribute to the reduction of dopamine in the brain ... pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against ...
http://nrl.northumbria.ac.uk/id/eprint/48992/
Catechols | Profiles RNS
"Catechols" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Catechols" by people in this website by year, and whether " ... Below are the most recent publications written about "Catechols" by people in Profiles. ...
https://profiles.jefferson.edu/display/8061
Catechol Adhesives - NanosfunCatechol Adhesives - Nanosfun
Catechol Adhesives S.L. is a Spin-Off with origin in Nanosfun and now a company founded by BeAble Capital, the ICN2 and the ... formulation and optimization of bioinspired polymeric products based on the chemistry of catechols and thiols/disulfides that ...
https://nanosfun.com/tech-transfer/spin-offs-2-2/catechol-adhesives/
The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and...The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and...
catechol-O-methyltransferase (COMT); shizophrenia; alcohol dependence; smoking; association study. Subjects:. BIOMEDICINE AND ... The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and ... The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and ...
http://fulir.irb.hr/2357/
Opaline® | SolvayOpaline® | Solvay
Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound essentially used as building block. It is ...
https://www.solvay.com/en/brands/opaline
Catechol 60c by DAdamo Personalized-GP DD0028 0NDE0Catechol 60c by D'Adamo Personalized-GP DD0028 0NDE0
Catechol 60c by DAdamo Personalized-
https://www.iplanethealth.com/Catechol-60c-by-D
Catechol 60 Vcaps, DAdamo Personalized Nutrition - New HarmonyCatechol 60 Vcaps, D'Adamo Personalized Nutrition - New Harmony
Catechol offers a unique three-layer design that provides optimal support for better health. The first layer contains a base of ... Be the first to review "Catechol 60 Vcaps, DAdamo Personalized Nutrition" Cancel reply. You must be logged in to post a review ... Every batch of Right 4 Your Types Catechol is made without the most common food allergens, and contains no artificial colors, ... Right 4 Your Type offers a product called Catechol, a natural dietary supplement that supports a personalized approach to ...
https://www.newharmony.ie/product/catechol-60-caps/
Membrane-Bound (MB) Catechol-O-Methyltransferase (COMT) Genetic Polymo by Y. Ji, James E. Olson et al."Membrane-Bound (MB) Catechol-O-Methyltransferase (COMT) Genetic Polymo" by Y. Ji, James E. Olson et al.
Membrane-Bound (MB) Catechol-O-Methyltransferase (COMT) Genetic Polymorphisms, Catechol Estrogen Conjugation and Breast Cancer ... Catechol-O-Methyltransferase (COMT) Genetic Polymorphisms, Catechol Estrogen Conjugation and Breast Cancer Risk Reduction. ...
https://corescholar.libraries.wright.edu/ncbp/907/
COMT gene: MedlinePlus GeneticsCOMT gene: MedlinePlus Genetics
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Learn about this gene and related ... Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L. Catechol-O-methyltransferase gene Val/Met ... Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which ... A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the ...
https://medlineplus.gov/genetics/gene/comt/
Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes :: MPG.PuReSequence Programming with Dynamic Boronic Acid/Catechol Binary Codes :: MPG.PuRe
Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes ... 2019). Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes. Journal of the American Chemical Society, 141(36 ... Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes Hebel, M., Riegger, A., Zegota, M. M., Kizilsavas, G., ...
https://pure.mpg.de/pubman/faces/ViewItemFullPage.jsp?itemId=item_3164689
A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role...A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role...
N2 - We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol ... AB - We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol ... We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol ... The influence of the catechol moiety on the cytotoxicity and genotoxicity of new lignan derivatives has been investigated. The ...
https://research.abo.fi/en/publications/a-selective-de-o-methylation-of-guaiacyl-lignans-to-corresponding
The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion...The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion...
Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green ... The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion ... The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion ...
https://centaur.reading.ac.uk/27765/
Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine 3,5 monophosphate (cAMP)...Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine 3',5' monophosphate (cAMP)...
T1 - Catechol estrogens (CE). T2 - inhibition of estrogen elicited stimulation of hypothalamic adenosine 3,5 monophosphate ( ... Paul S, Stalvey LP, Skolnick P. Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine ... Catechol estrogens (CE): inhibition of estrogen elicited stimulation of hypothalamic adenosine 3,5 monophosphate (cAMP) ... Paul, S., Stalvey, L. P., & Skolnick, P. (1977). Catechol estrogens (CE): inhibition of estrogen elicited stimulation of ...
https://profiles.wustl.edu/en/publications/catechol-estrogens-ce-inhibition-of-estrogen-elicited-stimulation
Using a collection of nonfunctional missense mutants in the β-galactosidase and catechol 2,3-dioxygenase enzymes to better...
... β-galactosidase and catechol 2,3-dioxygenase. This collection of missense mutants yielded important information regarding the ... Using a collection of nonfunctional missense mutants in the β-galactosidase and catechol 2,3-dioxygenase enzymes to better ... Using a collection of nonfunctional missense mutants in the β-galactosidase and catechol 2,3-dioxygenase enzymes to better ... β-galactosidase and catechol 2,3-dioxygenase. This collection of missense mutants yielded important information regarding the ...
https://jewlscholar.mtsu.edu/items/c49c1222-92ca-4ef7-87a3-e423d23e9b2a
A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous...A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous...
The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. ... The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. PB - Wiley-Blackwell, ... The method is successfully applied for detection of catechol and hydroquinone in real samples analyses.", publisher = "Wiley- ... catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. It was found that oxidation current ...
https://cer.ihtm.bg.ac.rs/handle/123456789/2354?locale-attribute=sr_RS
Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol:...
Devanesan, P., Todorovic, R., Zhao, J., Gross, M. L., Rogan, E. G., & Cavalieri, E. L. (2001). Catechol estrogen conjugates and ... Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol: ... T1 - Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol ... Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with 4-hydroxyestradiol: ...
https://experts.nebraska.edu/en/publications/catechol-estrogen-conjugates-and-dna-adducts-in-the-kidney-of-mal
Indian Institute of Technology KharagpurIndian Institute of Technology Kharagpur
5. DNA binding and catechol oxidation * Alkaloids and Heterocycle Chemistry * Analytical Methods for Environment ...
http://www.iitkgp.ac.in/department/CY
COMTDopamineOxidationGenotypeEstrogensEnzymeGeneAbstractReactionMoietyPhenolPolymorphismsVitroEnzymesReductiveStimulationNeurotransmittersMethylationConcentrationsBindsComplexesAcidTemperature158MetGenesPathwayVariationChemistryDescriptorMoietiesSubstancesDetectionBrainSensorUniqueIronStudyEffectsActivityTimeResultsTypeFoodPresenceProperties
COMT18
  • The Minnesota Green Tea Trial was a 12-mo randomized, double-blind, placebo-controlled clinical trial of 937 healthy postmenopausal women assigned to either decaffeinated GTE (1315 mg total catechins/d) or a placebo, stratified by catechol-O-methyltransferase (COMT) genotype. (greenmedinfo.com)
  • Although the aetiology of aggression is multifactorial, three studies have reported associations between polymorphisms of the catechol-O-methyltransferase (COMT) gene and aggression in schizophrenia. (elsevier.com)
  • Membrane-Bound (MB) Catechol-O-Methyltransferase (COMT) Genetic Polymo" by Y. Ji, James E. Olson et al. (wright.edu)
  • The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. (medlineplus.gov)
  • The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain. (medlineplus.gov)
  • Other tissues, including the liver, kidneys, and blood, produce a shorter form of the enzyme called soluble catechol-O-methyltransferase (S-COMT). (medlineplus.gov)
  • A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain. (medlineplus.gov)
  • However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of the levodopa dose reaches the brain unchanged. (nwu.ac.za)
  • To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3 H- substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast and HEK293 cells) that had been transfected with the recombinant human transporters. (elsevier.com)
  • Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. (ox.ac.uk)
  • The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. (ox.ac.uk)
  • Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. (omicsdi.org)
  • Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. (omicsdi.org)
  • Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. (omicsdi.org)
  • By conducting a genetic study using the Genecept Assay, we were able to determine that the patient had overactive catechol- O -methyltranferase (COMT). (genomind.com)
  • In humans, the catechol- O -methyltransferase protein is encoded by the COMT gene. (genomind.com)
  • COMT, Catechol-O-methyl transferase, is an enzyme that degrades catecholamines-such as dopamine, epinephrine, and norepinephrine (or adrenaline and noradrenaline as they are called in the UK). (neuroamer.com)
  • Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. (sunderland.ac.uk)
Dopamine2
  • These compounds are expected to have a dual mode of action both beneficial against Parkinson's disease: they are designed to be inhibitors of catechol O-methyl transferase, which contribute to the reduction of dopamine in the brain, and to protect neurons against oxidative damage. (northumbria.ac.uk)
  • 3. Oxidation resulted from the coordination of the dopamine catechol moiety to the center of metal and the transfer of electrons. (myprojectideas.com)
Oxidation7
  • Under estrogenic imbalance, oxidation of catechol estrogens to quinones may complete with their detoxification by protective enzymes. (nebraska.edu)
  • Also, SiG1 was applied as the catalyst for the oxidation of phenol and catechol in the presence of hydrogen peroxide. (ncku.edu.tw)
  • The yields of Fe 2+ from SiG1 in the presence of catechol were limited by the equilibrium of reduction and the oxidation rate of iron(III, II) species. (ncku.edu.tw)
  • Catechol induced the reductive dissolution of SiG1 and then promoted its own oxidation along with that of phenol in the presence of hydrogen peroxide. (ncku.edu.tw)
  • By-products of catechol oxidation have demonstrated increased absorbance changes in a chitosan film in the UV and near UV range. (scitepress.org)
  • Oxidation with hydrogen peroxide gives catechol (1,2-dihydroxybenzene). (chemeurope.com)
  • Possible physiological effects were reported for cadmium and catechol only, which tended to increase the oxidation of proteins and hydrogen peroxide in the larvae. (bvsalud.org)
Genotype1
  • Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations in a Randomized Controlled Trial of Overweight and Obese Postmenopausal Women. (greenmedinfo.com)
Estrogens1
  • Formation of depurinating adducts by reaction of catechol estrogen-3,4-quinones with DNA was proposed to be a tumor initiating event by estrogens [E.L. Cavalieri et al. (nebraska.edu)
Enzyme1
  • In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone iri vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. (elsevier.com)
Gene2
  • Genome mining for VibH homologs reveals several species of Acinetobacter with a gene cluster that putatively encodes the biosynthesis of catechol siderophores with an amine core. (ucsb.edu)
  • Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. (omicsdi.org)
Abstract1
  • Abstract: The Southeast Asia Catechol market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by the end of 2024 with a CAGR of XX% from 2019 to 2024. (researchreporthub.com)
Reaction4
  • IMSEAR at SEARO: Catechol stimulation of ferricyanide Hill reaction by spheroplasts of cyanobacterium, Synechococcus cedrorum: effect of temperature on catechol-stimulated oxygen evolution. (who.int)
  • Upon reaction with catechol-derived quinones , we show that SifR dissociates from the DNA leading to regulon derepression, allowing the pneumococcus to access a catechol-derived source of Fe while minimizing reactive electrophile stress induced by quinones . (bvsalud.org)
  • The temperature optimum of the reaction rate of Catechol 2,3-dioxygenase (C23O) from the selected isolates was between 40 and 50°C while optimum pH for C23O activity was within pH 6 and 8. (sciepub.com)
  • Catechol intradiol dioxygenation is a unique reaction catalyzed by iron-dependent enzymes and non-heme iron(III) complexes. (cardiff.ac.uk)
Moiety2
  • The influence of the catechol moiety on the cytotoxicity and genotoxicity of new lignan derivatives has been investigated. (abo.fi)
  • The results obtained indicated that the presence of the catechol moiety sharply enhances the clastogenic potential (e. g. induction of chromosomal aberrations), the cytotoxicity and the modulation of cell cycle progression with respect to the parent compounds. (abo.fi)
Phenol3
  • An original study of an immobilized iron oxide catalyst (SiG1) with one hydroxylation intermediate of phenol (catechol) in the reductive dissolution process was performed. (ncku.edu.tw)
  • Only the hydroxylation intermediates of phenol (i.e. catechol and 1,4-hydroquinone) were able to reductively dissolve SiG1. (ncku.edu.tw)
  • We report the successful fabrication and testing of an optical MEMS sensor for the detection of the toxic phenol, catechol. (scitepress.org)
Polymorphisms1
  • Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. (nih.gov)
Vitro2
  • Thus, despite the in vitro antioxidant activity usually described for catechol derivatives, our results show for the first time the generation of a clastogenic potential, highly indicative of a long-term genetic and cancer risk. (abo.fi)
  • Effects of 4-tertiary butyl catechol on glutathione-metabolizing enzymes in vivo and in vitro. (cdc.gov)
Enzymes1
  • In order to better understand how missense mutants affect protein structure, a set of randomly generated nonfunctional missense mutants were isolated in two well-characterized enzymes, β-galactosidase and catechol 2,3-dioxygenase. (mtsu.edu)
Reductive2
  • The reductive dissolution of SiG1 not only occurred at acidic solution but also occurred at alkali solution in the presence of catechol. (ncku.edu.tw)
  • Silver nanoparticles are spontaneously formed inside of the PVCa phases due to the reductive properties of the catechol moieties. (elsevier.com)
Stimulation1
  • Catechol(o-dihydroxybenzene) at low concentrations (20-100 microM) stimulates FeCN-dependent O2 evolution of spheroplasts isolated from the cyanobacterium Synechococcus both in the presence and absence of DBMIB, an inhibitor of electron flow from PSII to PSI, the stimulation being two-fold with saturating concentration of (60 microM) catechol. (who.int)
Neurotransmitters3
  • In the brain, catechol-O-methyltransferase helps break down certain chemical messengers called neurotransmitters. (medlineplus.gov)
  • Catechol-O-methyltransferase helps maintain appropriate levels of these neurotransmitters in this part of the brain. (medlineplus.gov)
  • The change affects the stability and activity of catechol-O-methyltransferase, which alters the enzyme's ability to break down neurotransmitters in the prefrontal cortex. (medlineplus.gov)
Methylation2
  • A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). (abo.fi)
  • We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol derivatives by using IBX as primary oxidant under green conditions (dimethyl carbonate-H(2)O solvent) through an in situ reduction procedure. (abo.fi)
Concentrations2
  • Catechol-2,3-dioxygenase activity was determined by spectrophotometric method and the unit activity was calculated from standard curve prepared from varying concentrations of 2-hydroxymuconic aldehyde while lipolytic activity was determined by colorimetric method based on the activity in cleavage of p-nitrophenylpalmitate (p-NPP) at pH 8.0. (sciepub.com)
  • Concentrations as low as 1 mM catechol are detected while control experiments including ascorbic acid display no measurable response. (scitepress.org)
Binds2
  • Previous work established that membrane -anchored PiuA binds FeIII-bis-catechol or monocatechol complexes with high affinity, including the human catecholamine stress hormone , norepinephrine . (bvsalud.org)
  • Using a combination of kinetic measurements and computational modelling of multiple iron(III) catecholato complexes, we have elucidated the catechol cleavage mechanism and show that oxygen binds the iron center by partial dissociation of the substrate from the iron complex. (cardiff.ac.uk)
Complexes2
  • Consistent with this model, we show that CatE is an FeII-dependent 2,3-catechol dioxygenase with broad substrate specificity , YwnB is an NAD (P)H-dependent quinone reductase capable of reducing the oxidized and cyclized norepinephrine , adrenochrome , and YhdA is capable of reducing a number of FeIII complexes, including PiuA-binding transport substrates . (bvsalud.org)
  • These findings are consistent with a model where FeIII-catechol complexes serve as significant nutritional Fe sources in the host. (bvsalud.org)
Acid3
  • I thought of another, more economical idea for synthesizing catechol (since acetylsalicylic acid isn't exactly inexpensive). (sciencemadness.org)
  • The 2-hydroxyltoluene would be oxidized, then reacted with urea, then treated with calcium hypochlorite, and then diazotized with nitrous acid to yield catechol. (sciencemadness.org)
  • Our data show, for the first time, that caffeine, catechols and N-alkanoly-5-hydroxytryptamides are those coffee components that stimulate molecular mechanisms of stomach acid secretion in human stomach cells," Somoza said. (eurekalert.org)
Temperature3
  • attack a condenser to the flask, and heat to 240°C(bp of catechol) and keep on this temperature until no more catechol is distilled. (sciencemadness.org)
  • Analysis of the temperature effect on FeCN-supported O2 evolution by spheroplasts suggests that catechol shifts the temperature maxima to a lower temperature and thereby hastens the decay of O2 evolution capacity by heat as compared to the normal spheroplasts. (who.int)
  • Catechol also induces a change in the magnitude of activation energy for ferricyanide Hill activity of spheroplasts and lowers the transition temperature. (who.int)
158Met1
  • Pivac, Nela (2013) The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence . (irb.hr)
Genes1
  • Global transcriptomic analysis of a ΔsifR strain defines the SifR regulon as genes encoding a candidate catechol dioxygenase CatE, an uncharacterized oxidoreductase YwnB, a candidate flavin-dependent ferric reductase YhdA, a candidate heme -based ferric reductase domain-containing protein and the Piu ( pneumococcus iron uptake) Fe transporter (piuBCDA). (bvsalud.org)
Pathway1
  • Third, the most efficient protocatechuate decarboxylase AroY for conversion of the midstream pathway intermediate protocatechuate into catechol was identified out of several variants in native and codon optimized form and expressed together with the respective helper proteins. (bvsalud.org)
Variation2
  • The full functional implications of pharmacogenetic variation in the activities of catechol O-methyltransferase and histamine N-methyltransferase remain to be determined. (nih.gov)
  • Most studies have focused on the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase. (medlineplus.gov)
Chemistry1
  • The activity of the company consists in the design, development, formulation and optimization of bioinspired polymeric products based on the chemistry of catechols and thiols/disulfides that have physical and chemical properties that make them very suitable for the formulation of adhesives with application in the biomedical field, such as tissue repair, sutures and surgical interventions among others. (nanosfun.com)
Descriptor1
  • Catechols" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Moieties1
  • Plant-derived phenolic compounds, rich in catechol and pyrogallol moieties, can form multifunctional coatings on various substrates following polymerization under mildly alkaline conditions. (kit.edu)
Substances1
  • These substances include caffeine, catechols, and other ingredients. (eurekalert.org)
Detection2
  • Such prepared electrode was utilized for successive simultaneous detection of structurally similar compounds, 1,2- and 1,4-dihydroxibenzenes (catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. (ac.rs)
  • The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. (ac.rs)
Brain1
  • Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which organizes and coordinates information from other parts of the brain. (medlineplus.gov)
Sensor2
  • SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39. (bvsalud.org)
  • Our reported sensor takes advantage of this unique absorbance property to detect catechol by measuring the change in light intensity at 472 nm, thus eliminating non-specific responses that occur from other oxidized chemicals which do not cause the absorbance change. (scitepress.org)
Unique2
  • Catechol offers a unique three-layer design that provides optimal support for better health. (newharmony.ie)
  • In the present work, poly(vinyl catechol-block-styrene) PVCa-b-PSt synthesized with various compositions forms unique microphase-separated structures. (elsevier.com)
Iron2
  • The SiG1 used in this study reacted more efficiently with catechol than the other iron oxides. (ncku.edu.tw)
  • Here, we aimed at measuring the physiological responses of the black soldier fly H. illucens grown on food wastes (kitchen, fruit or vegetable wastes) contaminated by cadmium, iron, lead or catechol. (bvsalud.org)
Study1
  • In the present work, we report a solid-state NMR and DFT study of catechol on TiO 2 . (elsevier.com)
Effects2
  • The effects of noncytotoxic doses of 4-tertiary-butyl-catechol (98293) (TBC) on glutathione-S-transferase (GST) activity in the skin of male, 2 month old Uscd-mice and B16-murine-melanoma cells in culture were investigated. (cdc.gov)
  • However, organic wastes, including food wastes, may contain several pollutants such as heavy metals and catechol which could affect the bioconversion efficiency by incurring physiological costs that would be undetectable at the organismal level, i.e. have null to little effects on the life cycle of Hermetia illucens. (bvsalud.org)
Activity1
  • Little is known, however, about the relationship between catechol-O-methyltransferase activity and the specific mental and emotional problems characteristic of this condition. (medlineplus.gov)
Time1
  • I have been interested in preparing Benzene-1,2-diol (catechol) for some time. (sciencemadness.org)
Results2
  • These results suggest that lipophilic catechol brings about an alteration in membrane fluidity in cyanobacterial spheroplasts. (who.int)
  • Nandrolone is a deca-Durabolin (to which a decanter is added to boost the chemical structure) in which testosterone is combined with the drug nandrolone and other bioactive ingredient, such as the naturally occurring estrogenic and aromatherapositive chemical Estradiol, and/or the bisphenol F, the bisphenol S and catechol and other compounds, deca durabolin 100mg injection results in hindi. (noahsarkctcf.com)
Type1
  • Right 4 Your Type offers a product called Catechol, a natural dietary supplement that supports a personalized approach to nutritional stress support by helping to restore a state of calm and support optimal neurotransmitter balance. (newharmony.ie)
Food2
  • Every batch of Right 4 Your Type's Catechol is made without the most common food allergens, and contains no artificial colors, preservatives, flavors, or other ingredients. (newharmony.ie)
  • We found no evidence of deleterious impacts of food waste contamination by catechol or heavy metals on H. illucens. (bvsalud.org)
Presence1
  • A kinetic model was applied to obtain the estimated maximum concentration of Fe 2+ produced by SiG1 and estimated proportional constant in the presence of catechol at different pH conditions by using a trial and error method. (ncku.edu.tw)
Properties1
  • We investigate the absorption properties of two catechol-like molecules, i.e. (42papers.com)
NIOSH Skin Notation Profiles: Catechol (2019-118) | NIOSH | CDC
NIOSH Skin Notation Profiles: Catechol (2019-118) | NIOSH | CDC (cdc.gov)
RTECS:UX1050000 - Pyrocatechol - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
RTECS:UX1050000 - Pyrocatechol - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH (cdc.gov)
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COMT gene: MedlinePlus Genetics (medlineplus.gov)
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DailyMed - ENTACAPONE tablet, film coated (dailymed.nlm.nih.gov)
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Tolcapone Tablets 100 mg (dailymed.nlm.nih.gov)
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Entacapone Tablets USP, 200 mg (dailymed.nlm.nih.gov)
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Entacapone Tablets, USP Rx only Prescribing Information (dailymed.nlm.nih.gov)
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