Catechol Oxidase
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The pro-phenoloxidase of coleopteran insect, Tenebrio molitor, larvae was activated during cell clump/cell adhesion of insect cellular defense reactions. (1/360)
To characterize the proteins involved in cell clump/cell adhesion of insect cellular defense reactions, we induced the cell clump/cell adhesion reaction in vitro with the hemolymph of larvae of the coleopteran insect, Tenebrio molitor. The 72 kDa protein was specifically enriched in the residues of cell clump/cell adhesion and was purified to homogeneity. A cDNA clone for the 72 kDa protein was isolated. We found that the 72 kDa protein was an activated phenoloxidase from Tenebrio pro-phenoloxidase. We suggest that activated phenoloxidase is involved in the cell clump/cell adhesion reaction as well as in the synthesis of melanin. (+info)Prophenoloxidase-activating enzyme of the silkworm, Bombyx mori. Purification, characterization, and cDNA cloning. (2/360)
Prophenoloxidase-activating enzyme (PPAE) was purified to homogeneity as judged by SDS-polyacrylamide gel electrophoresis from larval cuticles of the silkworm, Bombyx mori. The purified PPAE preparation was shown to be a mixture of the isozymes of PPAE (PPAE-I and PPAE-II), which were eluted at different retention times in reversed-phase high performance liquid chromatography. PPAE-I and PPAE-II seemed to be post translationally modified isozymes and/or allelic variants. Both PPAE isozymes were proteins composed of two polypeptides (heavy and light chains) that are linked by disulfide linkage(s) and glycosylated serine proteases. The results of cDNA cloning, peptide mapping, and amino acid sequencing of PPAE revealed that PPAE is synthesized as prepro-PPAE with 441 amino acid residues and is activated from pro-PPAE by cleavage of a peptide bond between Lys152 and Ile153. The homology search showed 36.9% identity of PPAE to easter, which is a serine protease involved in dorso-ventral pattern formation in the Drosophila embryo, and indicated the presence of two consecutive clip-like domains in the light chain. A single copy of the PPAE gene was suggested to be present in the silkworm genome. In the fifth instar larvae, PPAE transcripts were detected in the integument, hemocytes, and salivary glands but not in the fat body or mid gut. A polypeptide cross-reactive to mono-specific anti-PPAE/IgG was transiently detected in the extract of eggs between 1 and 3 h after they were laid. (+info)Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (3/360)
The substrate specificity of catechol oxidase from Lycopus europaeus towards phenols is examined. The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. Substrates containing a -COOH group are inhibitors for catechol oxidase. The products of enzymic oxidation of caffeic acid were analyzed and isolated by HPLC with diode array detection. The neolignans of the 2,3-dihydro-1,4-benzodioxin type (3, 6-8), 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-2,3-dicarboxy-1,2-dihydro naphthaline (1) 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-3-carboxynaphthaline (5) and 2,6-bis-(3',4'-dihydroxyphenyl)-1-carboxy-3-oxacyclo-(3,0)-pent an-2-on-1-ene (4) were formed. A reaction mechanism for the formation of (1, 4 and 5) is discussed. (+info)Purification and cloning of the salivary peroxidase/catechol oxidase of the mosquito Anopheles albimanus. (4/360)
Salivary homogenates of the adult female mosquito Anopheles albimanus have been shown previously to contain a vasodilatory activity associated with a catechol oxidase/peroxidase activity. We have now purified the salivary peroxidase using high-performance liquid chromatography. The pure enzyme is able to relax rabbit aortic rings pre-constricted with norepinephrine. The peroxidase has a relative molecular mass of 66 907 as estimated by mass spectrometry. Amino-terminal sequencing allowed us to design oligonucleotide probes for isolation of cDNA clones derived from the salivary gland mRNA from female mosquitoes. The full sequence of the cDNA demonstrated homology between A. albimanus salivary peroxidase and several members of the myeloperoxidase gene family. A close comparison of A. albimanus salivary peroxidase with canine myeloperoxidase, for which the crystal structure is known, showed that all six disulfide bridges were conserved and demonstrated identity for all five residues associated with a Ca2+-binding site. In addition, 16 of 26 residues shown to be in close proximity to the heme moiety in the canine myeloperoxidase were identical. We conclude that the salivary peroxidase of A. albimanus belongs to the myeloperoxidase gene family. Other possible functions for this molecule in blood feeding are discussed. (+info)The phenoloxidases of the ascomycete Podospora anserina. Structural differences between laccases of high and low molecular weight. (5/360)
In order to investigate the extent of the relationship between the three copper-containing glycoproteins, laccases I, II and III (Mr70000, 80000 and 390000 respectively) of Podospora anserina, the following experiments were carried out on laccases II and III: (a) determination of amino acid composition; (b) determination of N-terminal and C-terminal amino acid; (c) determination of sugar composition; (d) dissociation studies on native and denatured laccases and also after removal of copper from the enzymes; (e) digestion of the carbohydrate moieties with the aid of glycosylhydrolases. A comparison between the results of these experiments and data previously obtained with laccase I allows the following conclusions to be drawn. 1. Laccases II and III are not identical. 2. Neither of these low molecular weight laccases are as complete molecules subunits of the oligomeric laccase I. 3. The possibility of partial identity of amino acid sequences of laccases I and III can not be excluded. 4. Laccase II possibly consists of subunits of Mr37000 whereas laccase III does not. 5. Digestion of 50% of the carbohydrate content leads to complete loss of serological specificity (serological reaction and cross reaction). This finding is discussed with regard to the possible role of the carbohydrate moiety as antigenic determinants and thus as the reason for the immunological relationship. As a consequence, at least three independent structural genes for laccases must be assumed. (+info)Molecular cloning and characterization of apricot fruit polyphenol oxidase. (6/360)
A reverse transcriptase-polymerase chain reaction experiment was done to synthesize a homologous polyphenol oxidase (PPO) probe from apricot (Prunus armeniaca var Bergeron) fruit. This probe was further used to isolate a full-length PPO cDNA, PA-PPO (accession no. AF020786), from an immature-green fruit cDNA library. PA-PPO is 2070 bp long and contains a single open reading frame encoding a PPO precursor peptide of 597 amino acids with a calculated molecular mass of 67.1 kD and an isoelectric point of 6.84. The mature protein has a predicted molecular mass of 56.2 kD and an isoelectric point of 5.84. PA-PPO belongs to a multigene family. The gene is highly expressed in young, immature-green fruit and is turned off early in the ripening process. The ratio of PPO protein to total proteins per fruit apparently remains stable regardless of the stage of development, whereas PPO specific activity peaks at the breaker stage. These results suggest that, in addition to a transcriptional control of PPO expression, other regulation factors such as translational and posttranslational controls also occur. (+info)A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes. (7/360)
Cell lines from the malaria vector Anopheles gambiae have been established as a tool for the study of the mosquito innate immune system in vitro. Here, we describe the first continuous insect cell line that produces prophenoloxidase (PPO). This cell line (4a-3B) expresses constitutively six PPO genes, three of which are novel (PPO4, PPO5, and PPO6). The PPO genes show distinct temporal expression profiles in the intact mosquito, spanning stages from the embryo to the adult in an overlapping manner. Transient induction of larva-specific PPO genes in blood-fed adult females suggests that the developmental hormone 20-hydroxyecdysone may be involved in PPO gene regulation. Indeed, exposure of 4a-3B cells to 20-hydroxyecdysone in culture results in induction of those PPO genes that are mainly expressed in early developmental stages, and repression of PPO5, which is preferentially expressed at the adult stage. The cell line shows bacteria-induced immune transcripts that encode defensin and Gram-negative bacteria-binding protein, but no induction of PPO transcripts. This cell line most likely derives from a hemocyte lineage, and represents an appropriate in vitro model for the study of the humoral and cellular immune defenses of A. gambiae. (+info)Studies on the phylogenetic relationships of melanogenic marine bacteria: proposal of Marinomonas mediterranea sp. nov. (8/360)
The polyphenol oxidase (PPO) activities of the marine melanogenic strains MMB-1T and 2-40 were compared. Both contained a multifunctional PPO able to oxidize a wide range of substrates. In spite of this similarity, phylogenetic studies based on 16S rRNA sequences showed that these strains are not closely related. Strain 2-40 is not related to any previously described genus. On the basis of these studies and morphological and physiological characteristics, it is proposed that strain MMB-1T (= CECT 4803T = ATCC 700492T) represents a new species in the genus Marinomonas, Marinomonas mediterranea sp. nov. (+info)
Catechol oxidase
... to eliminate catechol oxidase catalytic activity, a popular strategy is decreasing the pH with citric acid. Catechol oxidase is ... In plants, catechol oxidase plays a key role in enzymatic browning by catalyzing the oxidation of catechol to o-quinone in the ... Catechol oxidase is a copper oxidase that contains a type 3 di-copper cofactor and catalyzes the oxidation of ortho-diphenols ... Polyphenol oxidases are a family of di-copper metalloenzymes that include tyrosinase and catechol oxidase. In plants, both ...
Catechol oxidase (dimerizing)
In enzymology, a catechol oxidase (dimerizing) (EC 1.1.3.14) is an enzyme that catalyzes the chemical reaction 4 catechol + 3 ... The systematic name of this enzyme class is catechol:oxygen oxidoreductase (dimerizing). Nair PM, Vining LC (July 1964). " ... the two substrates of this enzyme are catechol and O2, whereas its two products are [[dibenzo[1,4]dioxin-2,3-dione]] and H2O. ... "Enzymic oxidation of catechol to diphenylenedioxide-2,3-quinone". Archives of Biochemistry and Biophysics. 106: 422-7. doi: ...
Polyphenol oxidase
... catechol oxidases). The substrate preference of tyrosinases and catechol oxidases is controlled by the amino acids around the ... A mixture of monophenol oxidase and catechol oxidase enzymes is present in nearly all plant tissues, and can also be found in ... catechol oxidase Tyrosinase "Polyphenol Oxidase". Worthington Enzyme Manual. Retrieved 13 September 2011. McLarin, Mark-Anthony ... A monomeric catechol oxidase from Populus nigra converts caffeic acid to quinone and melanine at injured cells. ...
Light skin in Japanese culture
Many of these active ingredients work through inhibiting catechol oxidase. Some types of BB cream, VIORIS products are also ...
Morpheein
Harel, E.; Mayer, A.M. (1968). "Interconversion of sub-units of catechol oxidase from apple chloroplasts". Phytochemistry. 7 (2 ... Massey, V; Curti, B; Ganther, H (1966). "A temperature-dependent conformational change in D-amino acid oxidase and its effect ... "Association-dissociation phenomena of D-amino acid oxidase". The Journal of Biological Chemistry. 241 (10): 2358-66. doi: ... "Hysteresis and Positive Cooperativity of Iceberg Lettuce Polyphenol Oxidase". Biochemical and Biophysical Research ...
Aureusidin synthase
Klabunde T, Eicken C, Sacchettini JC, Krebs B (December 1998). "Crystal structure of a plant catechol oxidase containing a ... Robinson SP, Dry I (May 1992). "Broad Bean Leaf Polyphenol Oxidase Is a 60-Kilodalton Protein Susceptible to Proteolytic ... Aureusidin synthase is homologous to plant polyphenol oxidase (PPO), but contains certain significant modifications. While PPO ... a polyphenol oxidase homolog responsible for flower coloration". FEBS Letters. 499 (1-2): 107-11. doi:10.1016/S0014-5793(01) ...
Bernt Krebs
His pioneering crystal structures of purple acid phosphatase from kidney bean and of catechol oxidase from sweet potatoes have ... Klabunde, Thomas; Eicken, Christoph; Sacchettini, James C.; Krebs, Bernt (1998). "Crystal structure of a plant catechol oxidase ... catechol oxidase, tyrosinase). These investigations have led to catalytically active models as thermally stable and selective ...
Tyrosinase
The activity of tyrosinase is similar to catechol oxidase, a related class of copper oxidase. Tyrosinases and catechol oxidases ... In the presence of catechol, benzoquinone is formed (see reaction below). Hydrogens removed from catechol combine with oxygen ... Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly ... Mayer AM (Nov 2006). "Polyphenol oxidases in plants and fungi: going places? A review". Phytochemistry. 67 (21): 2318-31. doi: ...
Hemocyanin
... also exhibits phenol oxidase activity, but with slowed kinetics from greater steric bulk at the active site. Partial ... Decker H, Tuczek F (August 2000). "Tyrosinase/catecholoxidase activity of hemocyanins: structural basis and molecular mechanism ... Hemocyanin is homologous to the phenol oxidases (e.g. tyrosinase) since both proteins share type 3 Cu active site coordination ... denaturation actually improves hemocyanin's phenol oxidase activity by providing greater access to the active site. ...
Monoamine oxidase A
Leuchter AF, McCracken JT, Hunter AM, Cook IA, Alpert JE (August 2009). "Monoamine oxidase a and catechol-o-methyltransferase ... Binda C, Mattevi A, Edmondson DE (2011). "Structural properties of human monoamine oxidases a and B". Monoamine Oxidase and ... Monoamine oxidase B Monoamine oxidase inhibitor - a class of antidepressant drugs that block or inactivate one or both MAO ... Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the MAOA gene. This gene is one of two ...
Rs4680
"An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans". ... It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide ... "SZGene". Martin Reuter & Juergen Hennig (July 2005). "Association of the functional catechol-O-methyltransferase VAL158MET ... "A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait ...
Phragmatopoma californica
Catechol Oxidase Catalyzed Curing through Peptidyl-DOPA". Biomacromolecules. 14 (5): 1607-1617. doi:10.1021/bm400251k. PMID ...
Artificial enzyme
... and catechol oxidase). Artificial enzymes have been designed from scratch via a computational strategy using Rosetta. A ... A Pd12 coordination cage as a photoregulated oxidase-like nanozyme was developed. An NADPH oxidase-like nanozyme was developed ... Co/C as an NADH oxidase mimic was reported. An iron oxide nanozyme was used to target biofilms causing tooth decay. A new ... Oxidase-like nanoceria was used for developing self-regulated bioassays. Multi-enzyme mimicking Prussian blue was developed for ...
Adrenergic agonist
There is also enzymatic degradation of the catecholamines by two main enzymes - monoamine oxidase and catechol-o-methyl ...
Copper naproxen
... catechol oxidase, and antimicrobial activities". Journal of Coordination Chemistry. 67 (4): 670-683. doi:10.1080/00958972.2014. ...
Salomon Z. Langer
Monoamine oxidase and catechol-O-methyl transferase activities in cat nictitating membrane and rat and guinea-pig vas deferens ...
Catechol
... along with the enzyme polyphenol oxidase (also known as catecholase, or catechol oxidase). Upon mixing the enzyme with the ... catechol was listed as pyrocatechol. In 1879, the Journal of the Chemical Society recommended that catechol be called "catechol ... Catechol occurs as feathery white crystals that are very rapidly soluble in water. Catechol was first isolated in 1839 by Edgar ... Iron-containing dioxygenase enzymes catalyze the cleavage of catechol. Catechols convert to the semiquinone radical. At pH = 7 ...
Revised NEO Personality Inventory
... monoamine oxidase A and catechol-O-meethyltransferase genes". Neuroscience Research. 54 (3): 180-185. doi:10.1016/j.neures. ...
Mandelic acid
... of mandelic acid are formed as a result of metabolism of adrenaline and noradrenaline by monoamine oxidase and catechol-O- ...
Food browning
Generally, it is a chemical reaction involving polyphenol oxidase (PPO), catechol oxidase, and other enzymes that create ... Chelating agents − Polyphenol oxidase requires copper as a cofactor for its functionality, thus copper-chelating agents inhibit ... The rate of enzymatic browning is reflected by the amount of active polyphenol oxidases present in the food. Hence, most ... Contact between the phenolic compounds in the vacuole of the grape cell and the polyphenol oxidase enzyme (located in the ...
Adrenaline
... and metabolism by monoamine oxidase and catechol-O-methyl transferase. Extracts of the adrenal gland were first obtained by ... Oanca G, Stare J, Mavri J (December 2017). "How fast monoamine oxidases decompose adrenaline? Kinetics of isoenzymes A and B ...
Homovanillic acid
... is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O- ...
History of catecholamine research
In the case the catecholamines, however, the enzymes of degradation monoamine oxidase and catechol-O-methyl transferase, like ... An enzyme tyramine oxidase described in 1928 also oxidized dopamine, noradrenaline and adrenaline. It was later named monoamine ... Mary Lilias Christian Hare (1928). "Tyramine oxidase. I. A new enzyme system in liver". Biochemical Journal. 22 (4): 968-979. ... In this respect, ″amino-ethanol-catechol″ - noradrenaline - mimicked sympathetic nerves more closely than adrenaline did. The ...
Dopamine
... is broken down into inactive metabolites by a set of enzymes-monoamine oxidase (MAO), catechol-O-methyl transferase ( ... Once back in the cytosol, dopamine can either be broken down by a monoamine oxidase or repackaged into vesicles by VMAT2, ... A dopamine molecule consists of a catechol structure (a benzene ring with two hydroxyl side groups) with one amine group ... Both isoforms of monoamine oxidase, MAO-A and MAO-B, effectively metabolize dopamine. Different breakdown pathways exist but ...
Childhood schizophrenia
D-amino acid oxidase, proline dehydrogenase, catechol-Omethyltransferase, and regulator of G protein signaling. There have also ... An important gene for adolescent-onset schizophrenia is the catechol-O-methyltransferase gene, a gene that regulates dopamine. ...
3,4-Dihydroxyphenylacetic acid
Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order ...
List of recombinant proteins
These include both catechol oxidases and tyrosinases. In additional to research, PPOs have also found applications as ... Tonin F, Rosini E, Piubelli L, Sanchez-Amat A, Pollegioni L (July 2016). "Different recombinant forms of polyphenol oxidase A, ... Insulin-like growth factor 1 (IGF-1) Rasburicase, a Urate Oxidase analog sold as Elitek from Sanofi Bovine somatotropin (bST) ... Envelope protein of the hepatitis B virus marketed as Engerix-B by SmithKline Beecham HPV Vaccine proteins Polyphenol oxidases ...
List of enzymes
Catechol oxidase EC 1.10.3.1 Laccase EC 1.10.3.2 Category:EC 1.10.99 (with other acceptors) Category:EC 1.11.1 (peroxidases) ... Glucose oxidase EC 1.1.3.4 L-gulonolactone oxidase EC 1.1.3.8 Thiamine oxidase EC 1.1.3.23 Xanthine oxidase EC 1.1.3.32 ... Sarcosine oxidase EC 1.5.3.1 Dihydrobenzophenanthridine oxidase EC 1.5.3.12 Category:EC 1.5.4 (with a disulfide as acceptor) ... Urate oxidase EC 1.7.3.3 Category:EC 1.7.7 (with an iron-sulfur protein as acceptor) Category:EC 1.7.99 (with other acceptors) ...
Serafim Guimarães
Metabolizing enzymes, namely monoamine oxidase und catechol-O-methyl transferase (COMT), as well as carrier proteins for the ... amount of smooth muscle of venous tissue and the degree of supersensitivity to isoprenaline caused by inhibition of catechol-O- ...
Oxidative enzyme
... the oxidative enzymes like polyphenol oxidase and catechol oxidase oxidize the fruit (electrons are lost to the air). Such ... Two most common types of oxidative enzymes are peroxidases, which use hydrogen peroxide, and oxidases, which use molecular ...
Meredith Shiels
Catechol-O-methyltransferase, Dopamine Beta-Hydroxylase and Monoamine Oxidase-A. Shiels' dissertation was titled AIDS-defining ...
Xerocomic acid
An oxidase acting on xerocomic acid is responsible for the "bluing" reaction seen in mushrooms. Condensation of two units of ... Catechols, Furanones, Carboxylic acids). ...
Hinokitiol
It is stable to alkali and acids, forming salts or remaining unchanged, but does not convert to catechol derivatives. ... particularly tyrosinase and other polyphenol oxidases by chelating copper ions. This effect has been shown on different ...
Aureusidin
... a polyphenol oxidase homolog responsible for flower coloration. T. Nakayama, 2001 Aureusidin synthase on uniprot.org v t e ( ... Catechols, Resorcinols, All stub articles, Aromatic compound stubs). ...
Indole-5,6-quinone
... it is mediated by the tyrosinase type polyphenol oxidase from tyrosine and catecholamines leading to the formation of catechol ...
Julius Axelrod
Working on monoamine oxidase (MAO) inhibitors in 1957, Axelrod showed that catecholamine neurotransmitters do not merely stop ... In 1958, Axelrod also discovered and characterized the enzyme catechol-O-methyl transferase, which is involved in the breakdown ... Tomchick, Robert; Axelrod, Julius (September 1958). "Enzymatic O-Methylation of Epinephrine and Other Catechols - Axelrod and ...
Methyltransferase
Catechol-O-methyltransferase (COMT) degrades a class of molecules known as catcholamines that includes dopamine, epinephrine, ... Class C methylase has homologous sequence with the RS enzyme, coproporphyrinogen III oxidase (HemN), which also catalyzes the ... "COMT catechol-O-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. Ragsdale, S.W. "Catalysis of ... Examples include: Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate- ...
Antioxidant
In almost all land animals, urate oxidase further catalyzes the oxidation of uric acid to allantoin, but in humans and most ... are extensively metabolized by catechol-O-methyltransferase which methylates free hydroxyl groups, and thereby prevents them ... Wu XW, Muzny DM, Lee CC, Caskey CT (January 1992). "Two independent mutational events in the loss of urate oxidase during ... Uric acid (UA) is an antioxidant oxypurine produced from xanthine by the enzyme xanthine oxidase, and is an intermediate ...
Norepinephrine
The initial step in the breakdown can be catalyzed by either of the enzymes monoamine oxidase (mainly monoamine oxidase A) or ... Norepinephrine consists of a catechol moiety (a benzine ring with two adjoining hydroxyl groups in the meta-para position), and ... Monoamine oxidase inhibitors are antidepressants that inhibit the metabolic degradation of norepinephrine as well as serotonin ... norepinephrine can either be broken down by monoamine oxidase or repackaged into vesicles by VMAT, making it available for ...
Transporter Classification Database
NADPH Oxidase Family 5.B.2 The Eukaryotic Cytochrome b561 (Cytb561) Family 5.B.3 The Geobacter Nanowire Electron Transfer (G- ... Family 1.D.50 The Amphiphilic bis-Catechol Anion Transporter (AC-AT) Family 1.D.51 The Protein Nanopore (ProNP) Family 1.D.52 ... Superfamily 3.D.4 Proton-translocating Cytochrome Oxidase (COX) Superfamily 3.D.5 The Na+-translocating NADH:Quinone ...
Hydroxytyrosol
It is a derivative, formally speaking, of catechol. It or its derivatives occurs in olives and in wines The olives, leaves, and ... Monoamine oxidase inhibitors, Phytoestrogens). ...
Tolcapone
Catechol-O-methyltransferase inhibitors, Catechols, Hepatotoxins, Hoffmann-La Roche brands, Nitrophenols, Benzophenones, 4- ... Combining tolcapone with non-selective monoamine oxidase inhibitors such as phenelzine or tranylcypromine is contraindicated. ... March 2012). "Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors". Acta ... Manikumar G, Jin C, Rehder KS (2008). "Convenient Synthesis of Tolcapone, a Selective Catechol‐O‐methyltransferase Inhibitor". ...
L-DOPA
The oxidative stress is caused by the formation of reactive oxygen species (H2O2) during the monoamine oxidase led metabolism ... l-DOPA can be directly metabolized by catechol-O-methyl transferase to 3-O-methyldopa, and then further to vanillactic acid. ... The long term use of L-Dopa increases oxidative stress through monoamine oxidase led enzymatic degradation of synthesized ...
Apocynin
Li N, Zhang G, Yi FX, Zou AP, Li PL (2005). "Activation of NAD(P)H oxidase by outward movements of H+ ions in renal medullary ... Catechols). ... Apocynin is an inhibitor of NADPH oxidase activity and thus is ... Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in ... It is soluble in hot water, alcohol, benzene, chloroform, and ether.[citation needed] NADPH oxidase is an enzyme that ...
Catecholamine
They can be degraded either by methylation by catechol-O-methyltransferases (COMT) or by deamination by monoamine oxidases (MAO ... Catechol can be either a free molecule or a substituent of a larger molecule, where it represents a 1,2-dihydroxybenzene group ... High levels of catecholamines can also be caused by monoamine oxidase A (MAO-A) deficiency, known as Brunner syndrome. As MAO-A ... Catabolism of catecholamines is mediated by two main enzymes: catechol-O-methyltransferase (COMT) which is present in the ...
List of MeSH codes (D08)
... catechol oxidase MeSH D08.811.682.690.708.125.500 - monophenol monooxygenase MeSH D08.811.682.690.708.170 - cytochrome p-450 ... sarcosine oxidase MeSH D08.811.682.662.640 - proline oxidase MeSH D08.811.682.662.680 - pyridoxamine-phosphate oxidase MeSH ... d-amino-acid oxidase MeSH D08.811.682.664.500.261 - d-aspartate oxidase MeSH D08.811.682.664.500.398 - glutamate dehydrogenase ... proline oxidase MeSH D08.811.682.664.500.848 - protein-lysine 6-oxidase MeSH D08.811.682.664.500.924 - valine dehydrogenase ( ...
Understanding the mechanisms of placebo and nocebo effects
43 Leuchter AF , McCracken JT , Hunter AM , Cook IA , Alpert JE . Monoamine oxidase a and catechol-o-methyltransferase ... In another study, catabolic enzymes catechol-O-methyltransferase and monoamine oxidase A polymorphisms were examined in ... Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One. 2012;7(10): ... Interestingly, catechol-O-methyltransferase val158met polymorphisms have also been associated with placebo responsiveness in ...
SciELO - Brazil - Guidelines for Parkinson's disease treatment: consensus from the Movement Disorders Scientific Department of...
Monoamine oxidase type B inhibitors in early Parkinsons disease: meta-analysis of 17 randomised trials involving 3525 patients ... and catechol-ortho-methyltransferase (COMT) inhibitors. Nondopaminergic drugs are amantadine and anticholinergics. ... Monoamine oxidase type B inhibitors in early Parkinsons disease: meta-analysis of 17 randomised trials involving 3525 patients ... Macleod AD, Counsell CE, Ives N, Stowe R. Monoamine oxidase B inhibitors for early Parkinsons disease. Cochrane Database Syst ...
Frontiers | Forensic Autosomal Short Tandem Repeats and Their Potential Association With Phenotype
Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease
... monoamine oxidase B (MAOB; rs1799836), catechol-O-methyltransferase (COMT, rs4680), and dopamine transporter/solute carrier ... Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinsons disease ... Keywords: Parkinsons disease; dopamine metabolism; dopamine turnover; functional gene polymorphisms; monoamine oxidase B (MAOB ...
Functions Of Alkaline Phosphatase - 1035 Words | Cram
Intropin (dopamine) dosing, indications, interactions, adverse effects, and more
Molecule World | ScienceBlogs
Study Assessing Efficacy and Safety of AKST4290 in Subjects With Parkinson's Disease on Stable Dopaminergic Treatment -...
DHANANJAY DEY
has been evaluated as model system for the catechol oxidase enzyme by using 3,5-. di. -tert-butylcatechol (3,5-DTBC) as the ... The Cu(II) complex mimics the full catalytic cycle of the active site of catechol oxidase enzyme in acetonitrile medium with a ... In situ generation of Cu(I) species in the catalytic pathway of catechol oxidation was established by electrochemical study and ...
Pharmacotherapy Update - Ginkgo Biloba and Memory
DeCS
Catechol Oxidase Entry term(s). Diphenol Oxidase Diphenol Oxidases Oxidase, Catechol Oxidase, Diphenol Oxidase, Polyphenol ... Catechol oxidase Entry term(s):. Diphenol Oxidase. Diphenol Oxidases. Oxidase, Catechol. Oxidase, Diphenol. Oxidase, Polyphenol ... Catechol Oxidase - Preferred Concept UI. M0006511. Scope note. An enzyme of the oxidoreductase class that catalyzes the ... It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1. ...
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Pesquisa | BVS Bolivia
Straightforward purification method for the determination of the activity of glucose oxidase and catalase in honey by...
Adrenaline (epinephrine) : WFSA - Resources
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Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinsons ... Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinsons disease. Movement disorders : official ... Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinsons disease. ... Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with ...
Pluripotent stem cells for Parkinson's disease: progress and challenges | Stem Cell Research & Therapy | Full Text
COMT & MAO Inhibitors - Pharmacology Video | Lecturio
Other classes of medications work by preventing central and peripheral dopamine metabolism (monoamine oxidase (MAO) type B ... inhibitors, catechol O-methyltransferase (COMT) inhibitors, and carbidopa), or by exerting an antidyskinetic effect (amantadine ... Treatment includes supportive physical and emotional care plus medications such as levodopa-carbidopa, monoamine oxidase type B ... Treatment includes supportive physical and emotional care plus medications such as levodopa/carbidopa, monoamine oxidase type B ...
Adrenergic Agonists and Antagonists | Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e | AccessBiomedical...
Lecture notes on Pheochromocytoma: Hypersecretion of Catecholamines
MONOAMINE OXIDASE, THYROID ACTIVITY AND HYPERGLYCAEMIA IN THE FROG in: Journal of Endocrinology Volume 19 Issue 4 (1959)
... is not an important factor in the inactivation of catechol amines in the strongly stimulated frog, but the possibility is ... Estimations of monoamine oxidase (m.o.) activity in suspensions of frog liver taken at monthly intervals showed that activity ... 5. It is concluded that m.o. is not an important factor in the inactivation of catechol amines in the strongly stimulated frog ... MONOAMINE OXIDASE, THYROID ACTIVITY AND HYPERGLYCAEMIA IN THE FROG in Journal of Endocrinology ...
Parkinson Disease: Practice Essentials, Background, Anatomy
MPTP crosses the blood-brain barrier and is oxidized to 1-methyl-4-phenylpyridinium (MPP+) by monoamine oxidase (MAO)-B. [6] ... See Medication.) Entacapone (Comtan), a catechol-o-methyltransferase (COMT) inhibitor, reduces the peripheral metabolism of ... Monoamine oxidase (MAO)-B inhibitors, such as selegiline (Eldepryl) and rasagiline (Azilect) provide mild benefit as ... Caslake R, Macleod A, Ives N, Stowe R, Counsell C. Monoamine oxidase B inhibitors versus other dopaminergic agents in early ...
A REVIEW- PHYTOMEDICINES USED IN TREATMENT OF DIABETES | INTERNATIONAL JOURNAL OF PHARMACOGNOSY
MedlinePlus: Genes: C
Parkinson's Disease | RxWiki
SMPDB
Catechol O-. methyltransferase. Catechol O-. methyltransferase. Amine oxidase. [flavin-. containing] A. Amine oxidase. [flavin- ... oxidase. [copper-. containing]. Amine oxidase. [flavin-. containing] A. Tyrosinase. Catechol O-. methyltransferase. Aldehyde. ... Amine oxidase. [flavin-. containing] A. Amine oxidase. [flavin-. containing] A. Amine oxidase. [flavin-. containing] A. Amine ... Catechol O-. methyltransferase. Aldehyde. dehydrogenase,. dimeric. NADP-preferring. L-Tyrosine. Oxoglutaric acid. 4- ...
taoism - i am become computational
Plants | Free Full-Text | The Combination of Untargeted Metabolomics and Machine Learning Predicts the Biosynthesis of Phenolic...
The NFL model predicted that the biosynthesis of LMW compounds, which includes mainly tyrosols, coumarins, and catechols, was ... is required for the biosynthesis of tyrosols since this metal ion constitutes part of the active center of copper amine oxidase ... and catechols (Table S1). Due to their different biosynthetic origins, it is reasonable to find many factors causing the ... and LMW compounds were mainly represented by catechols and coumarins (Table S4). Accordingly, these compounds are suggested to ...
COMT3
- rs1799836), catechol-O-methyltransferase (COMT, rs4680), and dopamine transporter/solute carrier family 6 member 3 (DAT/SLC6A3, variable number tandem repeats) genes on 18 F-fluorodopa uptake and an effective distribution volume ratio (inverse of dopamine turnover) measured by 18 F-fluorodopa PET in 28 untreated PD patients. (nih.gov)
- Adrenaline is broken down by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), and may also be excreted unchanged by the kidney. (wfsahq.org)
- Other classes of medications work by preventing central and peripheral dopamine metabolism (monoamine oxidase (MAO) type B inhibitors, catechol O-methyltransferase (COMT) inhibitors, and carbidopa), or by exerting an antidyskinetic effect (amantadine). (lecturio.com)
Monoamine oxidas1
- Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population. (cdc.gov)
Enzyme5
- 1 ] + has been evaluated as model system for the catechol oxidase enzyme by using 3,5- di -tert-butylcatechol (3,5-DTBC) as the substrate in methanol medium, which revealed that the cationic complex efficiently inhibits catalytic activity with k cat value 9.65 × 10 2 h −1 . (ias.ac.in)
- The Cu(II) complex mimics the full catalytic cycle of the active site of catechol oxidase enzyme in acetonitrile medium with a turnover number of 4.788 × 10³ h⁻¹ along with the production of semiquinone radical and hydrogen peroxide. (ias.ac.in)
- An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (bvsalud.org)
- Some olives have the enzyme catechol oxidase that changes their color from green to red-brown or black, which caused people to be suspicious. (oliveknowledge.com)
- 5. It is concluded that m.o. is not an important factor in the inactivation of catechol amines in the strongly stimulated frog, but the possibility is discussed that under natural conditions of lower stress the high enzyme activity from August to November might be one factor tending to limit mobilization of liver glycogen. (bioscientifica.com)
Inhibitors2
- Conventional palliative treatments for PD attempt to replace lost dopamine activity or increase the activity of the remaining dopamine and include levodopa and carbidopa combinations, dopamine receptor agonists, muscarinic anticholinergics, and monoamine oxidase or catechol-o-methyl transferase inhibitors. (biomedcentral.com)
- Treatment includes supportive physical and emotional care plus medications such as levodopa-carbidopa, monoamine oxidase type B inhibitors, and dopamine agonists. (lecturio.com)
Metabolism1
- Catechol can also be formed from benzene dihydrodiol via metabolism by cytosolic dehydrogenases (Henderson et al. (cdc.gov)
Levodopa2
- Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease. (cdc.gov)
- The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. (cdc.gov)
Liver2
- 1. Estimations of monoamine oxidase ( m.o. ) activity in suspensions of frog liver taken at monthly intervals showed that activity was relatively constant during the greater part of the year (mean value 8·6 ± 0·332 μl. (bioscientifica.com)
- 1988). Benzene is initially metabolized by cytochrome P-450-dependent mixed function oxidases primarily in the liver via several toxification and detoxification (via conjugation) pathways. (cdc.gov)
Activity2
- In the article, the authors (Todd and Kenyon) provide some background information on the enzymatic activity of tyrosinase and compare it to the catechol oxidase that causes fruit to brown, especially apples. (scienceblogs.com)
- Glucose oxidase (GOX) and catalase (CAT) regulate the amount of H2O2 in honey, by generating or consuming it, so they are related to the antibacterial and antioxidant activity of honey. (ubu.es)
Monoamine oxidase5
- In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). (nih.gov)
- It is inactivated by reuptake in the presynaptic terminal and degraded by monoamine oxidase and catechol-O-methyltransferase. (medscape.com)
- Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population. (cdc.gov)
- Monoamine oxidase (MAO)-B inhibitors can be considered for initial treatment of early disease. (medscape.com)
- Mobility scores were better for participants receiving monoamine oxidase type B (MAO-B) inhibitors than for those receiving catechol-O-methyltransferase (COMT) inhibitors. (medscape.com)
Association of Catechol-O-Methyltransfera1
- 5. Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. (nih.gov)
Gene polymorphisms1
- 6. Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer. (nih.gov)
Polymorphisms2
- 12. Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility. (nih.gov)
- 16. Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population. (nih.gov)
Haplotypes3
- The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. (cdc.gov)
- 3. Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. (nih.gov)
- 11. The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study. (nih.gov)
Genetic1
- Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease. (cdc.gov)
Benzoquinone1
- An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (nih.gov)
Substance1
- 14. Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. (nih.gov)
Risk1
- Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease. (cdc.gov)