Catechol 1 2 dioxygenase. Medical search

A group of 1,2-benzenediols that contain the general formula R-C6H5O2.

Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.

Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.

An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.

Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.

2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.

An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27.

An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.

An enzyme that catalyzes the conversion of L-CYSTEINE to 3-sulfinoalanine (3-sulfino-L-alanine) in the CYSTEINE metabolism and TAURINE and hypotaurine metabolic pathways.

A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.

Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.

A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.

An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. It was formerly characterized as EC 1.13.1.6.

A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.

Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.

A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.

Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.

A bacterial genus of the order ACTINOMYCETALES.

An antiseptic and disinfectant aromatic alcohol.

Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.

An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

Benzoic acid or benzoic acid esters substituted with one or more chlorine atoms.

A widely used industrial solvent.

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.

A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.

A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.

Salts and esters of gentisic acid.

A genus of gram-negative, aerobic, motile bacteria that occur in water and soil. Some are common inhabitants of the intestinal tract of vertebrates. These bacteria occasionally cause opportunistic infections in humans.

Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

Derivatives of adipic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,6-carboxy terminated aliphatic structure.

An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.

A genus of gram-negative, straight or slightly curved rods which are motile by polar flagella and which accumulate poly-beta-hydroxybutyrate within the cells.

The functional hereditary units of BACTERIA.

A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.

A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.

A gram-positive organism found in dairy products, fresh and salt water, marine organisms, insects, and decaying organic matter.

Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.

Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.

A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A genus of coccoid bacteria in the family PLANOCOCCACEAE. They are widely distributed in various habitats including sea water, freshwater ponds, cyanobacterial mats, and in marine animals.

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)

Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.

A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.

Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The rate dynamics in chemical or physical systems.

A family of gram negative, aerobic, non-sporeforming, rod-shaped bacteria.

An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.

An enzyme that catalyzes the HYDROXYLATION of gamma-butyrobetaine to L-CARNITINE. It is the last enzyme in the biosynthetic pathway of L-CARNITINE and is dependent on alpha-ketoglutarate; IRON; ASCORBIC ACID; and OXYGEN.

A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.

An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.

A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

A family of compounds containing an oxo group with the general structure of 1,5-pentanedioic acid. (From Lehninger, Principles of Biochemistry, 1982, p442)

The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (From Enzyme Nomenclature, 1992) EC 5.5.

Inorganic or organic compounds that contain divalent iron.

An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.

A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

Proteins found in any species of bacterium.

Aminobenzenesulfonic acids. Organic acids that are used in the manufacture of dyes and organic chemicals and as reagents.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A group of proteins possessing only the iron-sulfur complex as the prosthetic group. These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.

Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.

A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.

The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.

A species of gram-negative bacteria in the genus PSEUDOMONAS, containing multiple genomovars. It is distinguishable from other pseudomonad species by its ability to use MALTOSE and STARCH as sole carbon and energy sources. It can degrade ENVIRONMENTAL POLLUTANTS and has been used as a model organism to study denitrification.

A species of gram-negative rod-shaped bacteria found ubiquitously and formerly called Comamonas acidovorans and Pseudomonas acidovorans. It is the type species of the genus DELFTIA.

A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.

Phenols substituted with one or more chlorine atoms in any position.

A species of gram-negative, aerobic bacteria found in soil and water. Although considered to be normally nonpathogenic, this bacterium is a causative agent of nosocomial infections, particularly in debilitated individuals.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

A deaminated metabolite of LEVODOPA.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.

Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.

A monooxygenase that catalyzes the conversion of BETA-CAROTENE into two molecules of RETINAL. It was formerly characterized as EC 1.13.11.21 and EC 1.18.3.1.

Stable oxygen atoms that have the same atomic number as the element oxygen, but differ in atomic weight. O-17 and 18 are stable oxygen isotopes.

Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.

A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)

Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

Proteins prepared by recombinant DNA technology.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

An herbicide with irritant effects on the eye and the gastrointestinal system.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.

A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.

A species of gram-negative bacteria in the genus PSEUDOMONAS. All strains can utilize FRUCTOSE for energy. It is occasionally isolated from humans and some strains are pathogenic to WATERMELON.

Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.

A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.

A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.

A colorimetric reagent for iron, manganese, titanium, molybdenum, and complexes of zirconium. (From Merck Index, 11th ed)

A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.

Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.

Compounds that contain a BENZENE ring fused to a furan ring.

An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3-hydroxykynurenine. It was formerly characterized as EC 1.14.1.2 and EC 1.99.1.5.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

Proteins, usually acting in oxidation-reduction reactions, containing iron but no porphyrin groups. (Lehninger, Principles of Biochemistry, 1993, pG-10)

Pigment obtained by the oxidation of epinephrine.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.

The relationships of groups of organisms as reflected by their genetic makeup.

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.

Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.

A family of gram-negative aerobic bacteria in the class BETA PROTEOBACTERIA, encompassing the acidovorans rRNA complex. Some species are pathogenic for PLANTS.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.

Word Origin: From the Greek "alkapton" meaning "darkening" and the suffix "-uria" indicating a condition characterized by excessive urine production.

There are three main types of tyrosinemia:

1. Tyrosinemia type I: This is the most severe form of the disorder, and it is caused by a complete deficiency of the enzyme fumarylacetoacetate hydrolase (FAH). This enzyme is essential for breaking down tyrosine, and without it, tyrosine builds up in the blood and tissues, leading to severe symptoms.
2. Tyrosinemia type II: This form of the disorder is caused by a deficiency of the enzyme tyrosine ammonia lyase (TAL). TAL is involved in the final step of tyrosine breakdown, and without it, tyrosine accumulates in the blood and tissues.
3. Tyrosinemia type III: This is a mild form of the disorder, and it is caused by a deficiency of the enzyme p-hydroxyphenylpyruvate dioxygenase (HPPD). HPPD is involved in the breakdown of tyrosine, but it is not essential for survival.

Symptoms of tyrosinemia can vary depending on the type and severity of the disorder, but they may include:

* Skin and joint problems
* Eye problems
* Liver and kidney damage
* Increased risk of infections
* Delayed growth and development
* Cognitive impairment

Tyrosinemia is usually diagnosed through a combination of clinical symptoms, laboratory tests, and genetic analysis. Treatment for the disorder typically involves a combination of dietary restrictions and medication. In some cases, liver transplantation may be necessary.

In summary, tyrosinemia is a group of rare genetic disorders that affect the breakdown of the amino acid tyrosine. The disorders are caused by deficiencies of specific enzymes involved in tyrosine metabolism, and they can lead to a range of symptoms and complications. Early diagnosis and appropriate treatment are important for managing the disorder and preventing long-term health problems.

Pascal RA, Huang DS (July 1986). "Reactions of 3-ethylcatechol and 3-(methylthio)catechol with catechol dioxygenases". Archives ... a family of catechol dioxygenases that cleaves the bond between the phenolic hydroxyl groups of catechol using an Fe3+ cofactor ... Two families of dioxygenases were discovered by Osamu Hayaishi and Kizo Hashimoto in 1950: catechol 1,2-dioxygenase and ... catechol dioxygenase, pyrocatechase, pyrocatechol 1,2-dioxygenase, CD I, CD II) is an enzyme that catalyzes the oxidative ring ...

https://en.wikipedia.org/wiki/Catechol_1,2-dioxygenase

Kobayashi S, Hayaishi O (1970). "Anthranilic acid conversion to catechol (Pseudomonas)". Methods Enzymol. 17A: 505-510. doi: ... catechol + CO2 + NAD(P)+ + NH3 The 5 substrates of this enzyme are anthranilate, NADH, NADPH, H+, and O2, whereas its 5 ... "Enzymatic formation of catechol from anthranilic acid". J. Biol. Chem. 239: 2204-2211. PMID 14209949. Portal: Biology v t e ( ... products are catechol, CO2, NAD+, NADP+, and NH3. This enzyme belongs to the family of oxidoreductases, specifically those ...

https://en.wikipedia.org/wiki/Anthranilate_1,2-dioxygenase_(deaminating,_decarboxylating)

3-dioxygenase) is an enzyme with systematic name catechol:oxygen 2,3-oxidoreductase (decyclizing). This enzyme catalyses the ... 3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, ... Catechol+2,3-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: long ... Catechol 2,3-dioxygenase (EC 1.13.11.2, 2,3-pyrocatechase, catechol 2,3-oxygenase, catechol oxygenase, metapyrocatechase, ...

https://en.wikipedia.org/wiki/Catechol_2,3-dioxygenase

I Enzymatic formation of catechol from benzene". Biochemistry. 7 (7): 2653-62. doi:10.1021/bi00847a031. PMID 4298226. Portal: ... and benzene dioxygenase. This enzyme participates in naphthalene and anthracene degradation. It has 4 cofactors: FAD, Iron, ... In enzymology, a benzene 1,2-dioxygenase (EC 1.14.12.3) is an enzyme that catalyzes the chemical reaction benzene + NADH + H+ ... The systematic name of this enzyme class is benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating). Other names in common use ...

https://en.wikipedia.org/wiki/Benzene_1,2-dioxygenase

3-dioxygenase (EC 1.13.11.2), and protocatechuate 3,4-dioxygenase (EC 1.13.11.3). The active site of catechol dioxygenases most ... Catechol dioxygenases are metalloprotein enzymes that carry out the oxidative cleavage of catechols. This class of enzymes ... 3-dioxygenase, is often used as a reporter to quantitate gene expression. An example of the reaction carried out by catechol 1, ... Catechol dioxygenases belong to the class of oxidoreductases and have several different substrate specificities, including ...

https://en.wikipedia.org/wiki/Catechol_dioxygenase

Extradiol Cleavage of 3-Methylcatechol by Catechol 1,2-Dioxygenase from Various Microorganisms. C. T. Hou, R. Patel and M. O. ... The isofunctional enzymes of catechol 1,2-dioxygenase from species of Acinetobacter, Pseudomonas, Nocardia, Alcaligenes and ... 3.0.CO;2-S. phenol-explorer.eu (Articles without InChI source, Articles without KEGG source, ECHA InfoCard ID from Wikidata, ... The enzyme 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase uses 1,2-dihydroxy-6-methylcyclohexa-3,5- ...

https://en.wikipedia.org/wiki/3-Methylcatechol

... may refer to: catechol dioxygenase Catechol 1,2-dioxygenase Catechol 2,3-dioxygenase This disambiguation page lists ...

https://en.wikipedia.org/wiki/Catechase

... dependent dioxygenases. The catechol dioxygenases, some of the most well-studied dioxygenase enzymes, use dioxygen to cleave a ... Two important groups of mononuclear, non-heme iron dioxygenases are catechol dioxygenases and 2-oxoglutarate (2OG)- ... Catechol dioxygenases are further classified as being "extradiol" or "intradiol," and this distinction is based on mechanistic ... In this respect, these enzymes are reminiscent of the intradiol catechol dioxygenases whereby the metal centers activate the ...

https://en.wikipedia.org/wiki/Dioxygenase

Muller R, Schmitt S, Lingens F (1982). "A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from ... Chloridazon-catechol dioxygenase (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-(2,3- ... Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl ... The systematic name of this enzyme class is 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase ( ...

https://en.wikipedia.org/wiki/Chloridazon-catechol_dioxygenase

... catechol + chloride + NAD+ + CO2 The 4 substrates of this enzyme are 2-chlorobenzoate, NADH, H+, and O2, whereas its 4 products ... are catechol, chloride, NAD+, and CO2. This enzyme belongs to the family of oxidoreductases, specifically those acting on ... In enzymology, a 2-chlorobenzoate 1,2-dioxygenase (EC 1.14.12.13) is an enzyme that catalyzes the chemical reaction 2- ... Fetzner S, Muller R, Lingens F (1989). "Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS". Biol. Chem. Hoppe-Seyler ...

https://en.wikipedia.org/wiki/2-chlorobenzoate_1,2-dioxygenase

... dioxygenases MeSH D08.811.682.690.416.277 - catechol 1,2-dioxygenase MeSH D08.811.682.690.416.305 - catechol 2,3-dioxygenase ... 4-dioxygenase MeSH D08.811.682.690.416.330 - 4-hydroxyphenylpyruvate dioxygenase MeSH D08.811.682.690.416.333 - indoleamine- ... 4-dioxygenase MeSH D08.811.682.690.416.722 - tryptophan oxygenase MeSH D08.811.682.690.562 - inositol oxygenase MeSH D08.811. ... catechol oxidase MeSH D08.811.682.690.708.125.500 - monophenol monooxygenase MeSH D08.811.682.690.708.170 - cytochrome p-450 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

4-dihydroxybenzoate to produce catechol and CO2. The enzyme protocatechuate 3,4-dioxygenase uses 3,4-dihydroxybenzoate and O2 ... 4-dioxygenase vanillate monooxygenase 3,4-dihydroxyphthalate decarboxylase 4,5-dihydroxyphthalate decarboxylase Degradation ... 23 (2): 201-208. doi:10.1016/j.tiv.2008.11.008. PMID 19095056. Anter, J.; Romero Jiménez, M.; Fernández Bedmar, Z.; Villatoro ... 1 (7): 232. doi:10.31989/ffhd.v1i7.127. ISSN 2160-3855. Pietta, P. G.; Simonetti, P.; Gardana, C.; Brusamolino, A.; Morazzoni, ...

https://en.wikipedia.org/wiki/Protocatechuic_acid

3-dioxygenase and 4-hydroxyphenylpyruvate dioxygenase all resemble glyoxalase I in structure. Finally, many proteins of unknown ... catechol 2,3-dioxygenase, 3,4-dihydroxyphenylacetate 2, ... 1: 100011. doi:10.1016/j.rechem.2019.100011. Rose IA (July 1957 ... 3-demethylubiquinone-9 3-O-methyltransferase and numerous dioxygenases such as biphenyl-2,3-diol 1,2-dioxygenase, ... 314 (Pt 2): 463-7. doi:10.1042/bj3140463. PMC 1217073. PMID 8670058. Saint-Jean AP, Phillips KR, Creighton DJ, Stone MJ (July ...

https://en.wikipedia.org/wiki/Lactoylglutathione_lyase

4-dicarboxylate dehydrogenase into a catechol intermediate. The catechol ring is then cleaved by PCA 3,4-dioxygenase before the ... 118 (1): 21-27. doi:10.1099/00221287-118-1-21. ISSN 1350-0872. Coghlan A. "Bacteria found to eat PET plastics could help do the ... 25 (1): 53-64. doi:10.1016/j.ejpe.2015.03.001. Misra J (April 2020). "Managing Wastewater Using Plastic Eating Bacteria - A ... Ideonella sakaiensis adhere to PET surface and use a secreted PET hydrolase, or PETase, to degrade the PET into mono(2- ...

https://en.wikipedia.org/wiki/Ideonella_sakaiensis

Junca, H.; Plumeier, I.; Hecht, H. J. R.; Pieper, D. H. (December 2004). "Difference in kinetic behaviour of catechol 2,3- ... dioxygenase variants from a polluted environment". Microbiology. 150 (12): 4181-4187. doi:10.1099/mic.0.27451-0. PMID 15583170 ... In recent years, 2-D electrophoresis has been widely accepted as a standard procedure to separate complex protein mixtures in ... 227 (1-2): 21-30. doi:10.1016/j.mce.2004.08.001. PMID 15501581. S2CID 1622208. Görg, A.; Weiss, W.; Dunn, M. J. (December 2004 ...

https://en.wikipedia.org/wiki/Tetrasodium_tris(bathophenanthroline_disulfonate)ruthenium(II)

Next, the diol is newly reduced by NADH to catechol. The catechol is then metabolized to acetyl CoA and succinyl CoA, used by ... In bacteria, dioxygenase enzyme can add an oxygen to the ring, and the unstable product is immediately reduced (by NADH) to a ... and hydroquinone to both benzenetriol and catechol. Hydroquinone, benzenetriol and catechol are converted to polyphenols. In ... catechol, hydroquinone and 1,2,4-trihydroxybenzene. Most of these metabolites have some value as biomarkers of human exposure, ...

https://en.wikipedia.org/wiki/Benzene

... related with the catechol and resorcinol groups and the oxidation is pH-dependent. The oxidation of the catechol 3',4'- ... Protocatechuic acid and hydroxyquinol undergo intradiol cleavage through protocatechuate 3,4-dioxygenase and hydroxyquinol 1,2- ... sulfation and methylation of the catechol group by catechol-O-methyl transferase, with only small amounts detected in plasma. ... dioxygenase to form β-carboxy cis, cis-muconic acid and maleyl acetate. Among fungi, degradation of catechin can be achieved by ...

https://en.wikipedia.org/wiki/Catechin

"The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5 ... 9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10". Applied and Environmental ... 9a-dioxygenase (EC 1.14.12.22, CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3- ... 9a-dioxygenase catalyses the first reaction in the pathway of carbazole degradation. Nam JW, Nojiri H, Noguchi H, Uchimura H, ...

https://en.wikipedia.org/wiki/Carbazole_1,9a-dioxygenase

3-dioxygenase, which mediates the electron transfer between catechol substrates and O2 to form a [M(II)(semiquinone)superoxo] ... "Characterization of an O2 Adduct of an Active Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase". Journal of the ... "A Hyperactive Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase". Journal of Biological Inorganic Chemistry. 16 (2): ... Que Jr, L.; Lipscomb, J. D.; Münck, E.; Wood, J. M. (1977-11-23). "Protocatechuate 3,4-dioxygenase: Inhibitor studies and ...

https://en.wikipedia.org/wiki/Lawrence_Que_Jr.

Catechol oxidase EC 1.10.3.1 Laccase EC 1.10.3.2 Category:EC 1.10.99 (with other acceptors) Category:EC 1.11.1 (peroxidases) ... 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal ... EC 1.14.12 Nitric oxide dioxygenase Category:EC 1.14.13 Nitric oxide synthase EC 1.14.13.39 Category:EC 1.14.14 Aromatase EC ... List of EC numbers (EC 5) List of EC numbers (EC 6) Dehydrogenase Luciferase DMSO reductase Category:EC 1.1.1 (with NAD+ or ...

https://en.wikipedia.org/wiki/List_of_enzymes

Iron-containing dioxygenase enzymes catalyze the cleavage of catechol. Catechols convert to the semiquinone radical. At pH = 7 ... catechol was listed as pyrocatechol. In 1879, the Journal of the Chemical Society recommended that catechol be called "catechol ... Catechol occurs as feathery white crystals that are very rapidly soluble in water. Catechol was first isolated in 1839 by Edgar ... Catechol has since been shown to occur in free form naturally in kino and in beechwood tar. Its sulfonic acid has been detected ...

https://en.wikipedia.org/wiki/Catechol

3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Inoue J, Shaw JP, Rekik M, ... catechol 2, ... for this enzyme is formed by meta ring cleavage of catechol (EC ... 2-Hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85, xylG [gene], praB [gene] ) is an enzyme with systematic name (2E, ... 2-hydroxymuconate-6-semialdehyde+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: ...

https://en.wikipedia.org/wiki/2-Hydroxymuconate-6-semialdehyde_dehydrogenase

Insight into the Mechanism of the Extradiol Catechol Dioxygenases". Journal of the American Chemical Society. 123 (21): 5030- ... Lin, Gang; Reid, Gillian; Bugg, Timothy D. H. (May 2001). "Extradiol Oxidative Cleavage of Catechols by Ferrous and Ferric ... 9 (1): 015025. doi:10.1088/2053-1583/ac3dd6. ISSN 2053-1583. Noori, Yasir J.; Thomas, Shibin; Ramadan, Sami; Smith, Danielle E ... 2 (4): 420-426. doi:10.1039/C5MH00030K. "Novel thin film approach for memory and energy harvesting devices". Printed ...

https://en.wikipedia.org/wiki/Gillian_Reid

Benzoic acid Catechol Hydrolyzable tannin Pyrogallol Syringol Syringaldehyde Syringic acid Shikimic acid Haslam, E.; Cai, Y. ( ... The oxidation is catalyzed by the enzyme gallate dioxygenase, an enzyme found in Pseudomonas putida. Oxidative coupling of ... In Book 34, Chapter 26 of his Natural History, Pliny states that verdigris (a form of copper acetate (Cu(CH3COO)2·2Cu(OH)2), ... Gallate 1-beta-glucosyltransferase catalyzes the glycosylation (attachment of glucose) of gallic acid. Gallic acid is an ...

https://en.wikipedia.org/wiki/Gallic_acid

Caffeate 3,4-dioxygenase is an enzyme that uses caffeic acid and oxygen to produce 3-(2-carboxyethenyl)-cis,cis-muconate. 3-O- ... The developing chemistry is similar to that of catechol or pyrogallol. It is also used as a matrix in MALDI mass spectrometry ... 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term ... 131 (1): 66-71. doi:10.1093/jn/131.1.66. PMID 11208940. "EC 4.3.1.11". www.chem.qmul.ac.uk. Archived from the original on 3 ...

https://en.wikipedia.org/wiki/Caffeic_acid

In vitro, the meta-hydroxyl group of catechol is methylated by catechol-O-methyltransferase. Four of the five hydroxyl groups ... 3-dioxygenase Quercetin 3-O-methyltransferase Quercetin-3-sulfate 3'-sulfotransferase Quercetin-3-sulfate 4'-sulfotransferase ... 126 (2): 485-93. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179. Juergenliemk G, Boje K, Huewel S, Lohmann C, Galla HJ, ... Retrieved 1 April 2018. "USDA Database for the Flavonoid Content of Selected Foods, Release 3" (PDF). U.S. Department of ...

https://en.wikipedia.org/wiki/Quercetin

Heating catechin past its point of decomposition releases pyrocatechol (also called catechol), which explains the common origin ... leucoanthocyanidin dioxygenase), E11, anthocyanidin reductase. HSCoA, Coenzyme A. L-Tyr, L-tyrosine, L-Phe, L-phenylalanine. ... 126 (2): 485-493. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179. Mueller-Harvey I, Feucht W, Polster J, Trnková L, ... Figure 1:Schematic overview of the flavan-3-ol (-)-epicatechin biosynthesis in plants: Enzymes are indicated in blue, ...

https://en.wikipedia.org/wiki/Flavan-3-ol

For example, Rhodococci expresses dioxygenases, which can be used to degrade benzotrifluoride, a recalcitrant pollutant. ... catechol, benzoate, and protocatechuic acid. Rhodococci are also capable of accumulating heavy metal ions, such as radioactive ... "Degradation of benzotrifluoride via the dioxygenase pathway in Rhodococcus sp. 065240". Bioscience, Biotechnology, and ... ISBN 978-1-904455-30-1. [1]. McLeod MP, Warren RL, Hsiao WW, Araki N, Mihre M, Fernandes C, Miyazawa D, Wong W, Lillquist AL, ...

https://en.wikipedia.org/wiki/Rhodococcus

4-dioxygenase EC 1.12.99.6: hydrogenase (acceptor) EC 1.13.11.1: catechol 1,2-dioxygenase EC 1.13.11.2: catechol 2,3- ... 3-dioxygenase EC 1.13.11.18: persulfide dioxygenase EC 1.13.11.19: cysteamine dioxygenase EC 1.13.11.20: cysteine dioxygenase ... dioxygenase EC 1.14.11.4: procollagen-lysine 5-dioxygenase EC 1.14.11.5: Now included with EC 1.14.11.6 thymine dioxygenase EC ... peptide-aspartate β-dioxygenase EC 1.14.11.17: taurine dioxygenase EC 1.14.11.18: phytanoyl-CoA dioxygenase EC 1.14.11.19: Now ...

https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_1)

Catechol 2,3-dioxygenases functional in oxygen-limited (hypoxic) environments. Appl Environ Microbiol 62(5):1728-1740. PMID: ... 3-dioxygenase. Publication(s) associated with this dataset: h4.sbrppubs { padding: 0 5px 2px 5px; border-bottom: 1px solid # ... Summary: Pseudomonas aeruginosa xylEJI104-1 gene for catechol 2, ... Title: Pseudomonas aeruginosa xylEJI104-1 gene for catechol 2,3 ...

https://tools.niehs.nih.gov/srp/data/dataset_details.cfm?dataset_id=2271

Autoxidation-product-initiated dioxygenases: vanadium-based, record catalytic lifetime catechol dioxygenase catalysis.. Yin CX ... complexes of tripodal monophenolate ligands as models for non-heme catechol dioxygenase enzymes: correlation of dioxygenase ... 3. Kinetic and mechanistic studies of vanadium-based, extended catalytic lifetime catechol dioxygenases.. Yin CX; Finke RG. J ... Iron(III)-catecholato complexes as structural and functional models of the intradiol-cleaving catechol dioxygenases. ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=16270992&mod=related&page=1&outid=&proj=

... under CATECHOL 1973-1974. History Note. 2006(1980); use DIOXYGENASES 1975-1979 & CATECHOL 1973-1974. Date Established. 2006/01/ ... Dioxygenases [D08.811.682.690.416] * AlkB Enzymes [D08.811.682.690.416.139] * Catechol 1,2-Dioxygenase [D08.811.682.690.416.277 ... 3-Hydroxyanthranilate 3,4-Dioxygenase [D08.811.682.690.416.328] * 4-Hydroxyphenylpyruvate Dioxygenase [D08.811.682.690.416.330] ... Catechol 1,2-Dioxygenase Preferred Concept UI. M0072800. Registry Number. EC 1.13.11.1. Related Numbers. 9027-16-1. Scope Note ...

https://meshb.nlm.nih.gov/record/ui?ui=D050548

2006(1980); use DIOXYGENASES 1975-1979 & CATECHOL 1973-1974. DeCS ID:. 50651 ... Catechol 1,2-Dioxygenase - Preferred Concept UI. M0072800. Scope note. An enzyme that catalyzes the oxidation of catechol to ... Catechol Catechol 1,2 Dioxygenase Catechol 1,2 Oxygenase Catechol 1,2-Oxygenase Catechol-1,2-Oxygenase Pyrocatechase ... Catechol 1,2-Dioxygenase Entry term(s). 1,2-Dioxygenase, Catechol 1,2-Dioxygenase, Pyrocatechol 1,2-Oxygenase, ...

https://decs.bvsalud.org/en/ths/resource/?id=50651

https://meshb-prev.nlm.nih.gov/record/ui?ui=D050548

RL also had a facilitating effect on catechol-1,2-dioxygenase (C12O) enzyme activity. Furthermore, RL increased Zeta potential ... 1, Hy-Line Brown laying hens (n = 45) were sampled according the oviposition cycle (at 0, 6, 12, and 18 h post-oviposition, and ... CoP2/Co2P Encapsulated in Carbon Nanotube Arrays to Construct Self-Supported Electrodes for Overall Electrochemical Water ... At 5 weeks, the expression of collagen type 1 and CD206 in the ASC-Exo group was significantly higher than that in the ASC-Ecto ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:Wang,+Jiajie

Dioxygenase N0000167851 Catechol 2,3-Dioxygenase N0000166550 Toluene 2,4-Diisocyanate N0000167971 L-Iditol 2-Dehydrogenase ... N0000167848 Cysteine Dioxygenase N0000167849 4-Hydroxyphenylpyruvate Dioxygenase N0000167863 gamma-Butyrobetaine Dioxygenase ... Catechol N0000168922 Receptors, Catecholamine N0000170679 DNA, Catenated N0000169495 alpha Catenin N0000169496 gamma Catenin ... 4-Dioxygenase N0000167858 4-Hydroxybenzoate-3-Monooxygenase N0000167883 Ethylmorphine-N-Demethylase N0000167919 Laccase ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202013-10-07.txt

RpoN (sigma 54) is required for conversion of phenol to catechol in Acinetobacter calcoaceticus.. J Bacteriol. 176(12):3493-9. ... Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2- ... dioxygenase in Acinetobacter calcoaceticus NCIB8250.. Mol Microbiol. 18(1):13-20.. Geissdörfer W, Frosch SC, Haspel G, Ehrt S, ... 285(2):455-61.. Baron U, Schnappinger D, Helbl V, Gossen M, Hillen W, Bujard H. 1999. Generation of conditional mutants in ...

https://microbiology.weill.cornell.edu/publications?page=5&s=year&o=asc&f%5Bauthor%5D=2229

... or maybe to a too high catalytic efficiency of them leading to an accumulation of catechol which can be toxic for the cell. ... or maybe to a too high catalytic efficiency of them leading to an accumulation of catechol which can be toxic for the cell. ... is present and two isozymes of catechol 1,2-dioxygenase (C1,2O) have been characterized. Kinetic analysis of A. radioresistens ... is present and two isozymes of catechol 1,2-dioxygenase (C1,2O) have been characterized. Kinetic analysis of A. radioresistens ...

https://iris.unito.it/handle/2318/52422

2-pyridylthio)methanido ligand: aromatic C-C bond cleavage of catecholate versus o-iminobenzosemiquinonate radical formation. ... complexes of tripodal monophenolate ligands as models for non-heme catechol dioxygenase enzymes: correlation of dioxygenase ... Iron(III) complexes of tridentate 3N ligands as functional models for catechol dioxygenases: the role of ligand N-alkyl ... A functional model of extradiol-cleaving catechol dioxygenases: mimicking the 2-his-1-carboxylate facial triad. ...

https://www.unboundmedicine.com/medline/citation/22847897/Dioxygen_reactivity_of_biomimetic_iron_catecholate_and_iron_o_aminophenolate_complexes_of_a_tris_2_pyridylthio_methanido_ligand:_aromatic_C_C_bond_cleavage_of_catecholate_versus_o_iminobenzosemiquinonate_radical_formation_

Catechol 2,3-dioxygenases functional in oxygen-limited (hypoxic) environments. Kukor JJ, Olsen RH. Kukor JJ, et al. Appl ... Under aerobic conditions with toluene-induced cells, strains expressing toluene dioxygenases (Pseudomonas putida F1, ... 2004 Feb;15(1):19-28. doi: 10.1023/b:biod.0000009947.09125.35. Biodegradation. 2004. PMID: 14971854 ... 1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA. ...

https://pubmed.ncbi.nlm.nih.gov/8975612/

HN - 2006(1980); use DIOXYGENASES 1975-1979 & CATECHOL 1973-1974 MH - Catechol 2,3-Dioxygenase UI - D050557 MN - D8.811.682.690 ... Dioxygenase UI - D050503 MN - D8.811.682.690.416.333 MS - A dioxygenase with specificity for the oxidation of the indoleamine ... HN - 2006 MH - Catechol 1,2-Dioxygenase UI - D050548 MN - D8.811.682.690.416.277 MS - An enzyme that catalyzes the oxidation of ... HN - 2006(1983) MH - gamma-Butyrobetaine Dioxygenase UI - D050563 MN - D8.811.682.690.708.401 MS - An enzyme that catalyzes the ...

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/.bkup/mshnew2006.10-03-2005.txt

... and V m is the reactions maximal speed in the case of catechol dioxygenase activity. ρp and De are the density of dried ... V. Sridevi 2. , M. N. N. Sai Rachana 1. , J. Akhila 1. , M. Yamini 1. , Katru Ramya Sugandhi 1. , Husam Talib Hamzah 3. , R. ... Ring fission takes place in the meta-pathway close to the two hydroxyl groups of catechol (extra diol fission). Catechol 2, 3- ... Depending on the strain, catechol is either oxidised by catechol 1,2-dioxygenase via the ortho-cleavage pathway, which results ...

https://www.granthaalayahpublication.org/journals/granthaalayah/article/download/IJRG22_A12_6463/5011?inline=1

Navy vessels with residence times of 1-, ~20-, and 31 weeks was conducted and compared with the seawater used to fill the tanks ... and catechol dioxygenase (catA/catE) genes (0.4%, 2.0%) decreased to their lowest relative proportion observed in any sample. ... ethylbenzene dioxygenase (etbAa), toluene monooxygenase (tmoA), benzene/toluene dioxygenase (todC1), and xylene monooxygenase ( ... 4). No catechols or aromatic dihydrodiol intermediates were measured in the Ship #3 water sample. Naphthoic and alkanoic acids ...

https://www.nature.com/articles/s41529-021-00207-z?error=cookies_not_supported&code=c715e812-d4dd-425d-b49a-fa26ada4ae10

Hydrocarbons are degraded (under aerobic conditions) via mono-oxygenases or di-oxygenases, and are subsequently carboxylated ... They are converted enzymatically to the natural intermediates of degradation, for example catechol and protecatechuate ( ... The initial step is usually performed via a dioxygenase and forms a dihydrodiol ... to central intermediates such as protocatechates and catechols. These compounds are further converted to tricarboxylic acid ...

https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/15750/5/1

... and catechol 2,3-dioxygenase (aphB) could not be found in the strain KF-1 genome. ... Table 2 summarizes the differential phenotypic characteristics of. Posted on February 29, 2016. by pkcp2456 ... Strain KF-1 has acquired the ability to utilize xenobiotic 3-C4-SPC, 3-C4-SPC-2H, 3-C5-SPC and 3-C5-SPC-2H, 4-sulfoacetophenone ... cDNA synthesis was performed from 1 ��g of total RNA using reagen. Posted on February 24, 2016. by pkcp2456 ...

https://pkcpathway.com/2016/02/

3-Dioxygenase" by people in this website by year, and whether "Catechol 2,3-Dioxygenase" was a major or minor topic of these ... "Catechol 2,3-Dioxygenase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via ... Below are the most recent publications written about "Catechol 2,3-Dioxygenase" by people in Profiles. ...

https://profiles.musc.edu/display/88807/

3,4-dioxygenase. Catechol O-. methyltransferase. Aldehyde. dehydrogenase,. dimeric. NADP-preferring. L-Tyrosine. Oxoglutaric ... 2. O. O. 2. 3,4-Dihydroxymandelaldehyde. NH. 3. H. 2. O. 2. H. 2. O. O. 2. Methylamine. H. 2. O. 2. Normetanephrine. H. 2. O. O ... 2. Dopaquinone. H. 2. O. Leucodopachrome. L-Dopachrome. O. 2. 5,6-Dihydroxyindole. H. 2. O. O. 2. Indole-5,6-quinone. H. 2. O. ... 2. Homovanillin. NADP. H. 2. O. p-Hydroxyphenylacetic acid. NADPH. O. 2. Dopamine. H. 2. O. Ascorbic acid. O. 2. Norepinephrine ...

https://pathman.smpdb.ca/view/SMP0000006

Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the ... Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the ... A BIOLOGICALLY ACTIVE GOLD COMPLEX: TRICHLORO[(2-PYRIDYL) METHANOL-N]GOLD(III) 1996 BRUNI B; M. FERRARONI; ORIOLI P; SPERONI G ... 1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 2001 Silvia Dei ...

https://flore.unifi.it/cris/rp/rp16420?type=all

A novel iron(III) complex with a tridentate ligand as a functional model for catechol dioxygenases: Properties and reactivity ... Yi, J. Y., Koo, J. Y., Lee, S., Shin, D. H. & Ha, J. S., 2000, In: Surface Review and Letters. 7, 1-2, p. 55-59 5 p.. Research ... Park, J. J., Park, H., Kim, Y. H. & Cho, K., 2000 Sept, In: Journal of Asia-Pacific Entomology. 3, 2, p. 121-126 6 p.. Research ... Lee, W. J., Kim, H. N., Cha, S. D. & Kwon, Y. R., 2000, In: Australian Computer Journal. 32, 2, p. 131-143 13 p.. Research ...

https://pure.korea.ac.kr/en/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Fclean_water_and_sanitation&format=&page=1621

keywords = "Catechol 2,3-dioxygenase, Gene disruption, Hydroxymuconicsemialdehyde hydrolase, Monooxygenase operon, Rhodococcus ... 3-dioxygenase enzymes, respectively. These enzymes catalyse the conversion of 3-(2-hydroxyphenyl) propionic acid to the ... catechol 2,3-dioxygenase), the ortho-hydroxyphenylpropionic acid catabolic pathway in Rhodococcus strain V49 (ATCC 19070) has ... 3-dioxygenase enzymes, respectively. These enzymes catalyse the conversion of 3-(2-hydroxyphenyl) propionic acid to the ...

https://faculty.kaust.edu.sa/en/publications/molecular-characterisation-of-a-rhodococcus-ohp-operon

Functional model for intradiol-cleaving catechol 1,2-dioxygenase: Synthesis, structure, spectra, and catalytic activity of iron ... 74-2 期刊論文 A new aspect of size effect on the high-spin(5T2)-low-spin(1A1) transition in supported ferrous complexes ... 83-1 期刊論文 Mössbauer and magnetic studies of copper(ii)-phthalocyanine effect on the spin states of bis(n-o-tolyl-2- ... 67-1 期刊論文 Mössbauer And Magnetic Properties Investigation Of The Spin States In 2 Or 3-Pyridyl Imine Complexes On Iron (Ii) ...

https://teacher.tku.edu.tw/StfTchrSmy.aspx?tid=t773156&k=&pg=16

Ghosh, Saheli and Qureshi, Asifa and Purohit, Hemant (2017) Enhanced expression of catechol 1,2 dioxygenase gene in biofilm ... 1-11. ISSN 1066-5277, ESSN: 1557-8666 Ndasi, N P and Sahu, N and Thul, S and Chandrashekhar, B and Sharma, A and Benoit, N M ... 1-5. Khairnar, Krishna and Raut, Mahendra P and Sanmukh, Swapnil G and Chandekar, Rajshree H and Paunikar, Waman N (2013) Novel ... 1-8. ISSN 1934-2616 Gujar, Vaibhav V. and Fuke, Priya and Khardenavis, Anshuman A. and Purohit, H. J. (2018) Annotation and De ...

http://neeri.csircentral.net/view/subjects/SUB50.type.html

https://chesar.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/12828/5/1

3-dioxygenase. Catechol-2,3-dioxygenase is being targeted into microcompartments, formed by engineered Aquifex aeolicus protein ... catechol and heavy metals. We are targeting catechol for degradation into common metabolic intermediates of the Krebs Cycle by ... The complex will then be purified and applied to the tailings for catechol degradation. By funnelling other pathways through ... Team:Toronto , Team Toronto:]] Enhanced Catechol Degradation via Metabolic Channeling in E. coli=== Oil sands, consisting of a ...

https://2010.igem.org/wiki/index.php?title=Jamboree/Project_Abstract/Team_Abstracts&action=edit

During phenol degradation, strain YZ4 learn more excreted both phenol hydroxylase and catechol 1,2-dioxygenase to efficiently ... 113 mu mol L(-1) for 4-methoxyphenol, 40 nA (mu mol L(-1))-1 for. Posted on January 26, 2021. by admin ... The 1/B(C6F5)(3)/AlEt3 catalytic system is effective for copolymerization of NBE with NBE-OCOCH3 and NBE-CH2OH, respectively, ... Conclusions: (1) PVAC-guided ablation (i.e., mapping and ablation with a single catheter) results in isolation of all PVs ...

https://mmp-signal.com/2021/01

4-Fluorocatechol + O2 <=> 3-fluoro-2-hydroxy-6-oxohexa-2,4-dienoate 1.13.11.2 catechol 2,3-dioxygenase - ... Your translated search: 3-fluoro-2-hydroxy-6-oxohexa-2,4-dienoate = 1 reactions were found. State Icon. Reaction. EC-Number ...

https://mmtb.brenda-enzymes.org/search/3-fluoro-2-hydroxy-6-oxohexa-2,4-dienoate%20=

3-Dioxygenase, Catechol use Catechol 2,3-Dioxygenase 2,3-Dioxygenase, Tryptophan use Tryptophan Oxygenase ... 3 Hydroxyanthranilate 3,4 Dioxygenase use 3-Hydroxyanthranilate 3,4-Dioxygenase 3 Hydroxyanthranilic Acid Oxygenase use 3- ... 2S,5R)-2,6-Diamino-5-hydroxyhexanoic Acid use Hydroxylysine (3 beta, 17 alpha)-19-Norpregn-4-en-20-yne-3,17 diol Diacetate use ... 1H-2-Benzopyran-1-ones use Isocoumarins 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl- use 2,3,4,5-Tetrahydro-7,8- ...

https://decs.bvs.br/I/DeCS2017_Alfab-0a9.htm

This intermediate would then add to taxifolin, via one of its hydroxyl groups, at the level of its catechol part. A second ... phenylalanine ammonia-lyase), CAD (cinnamyl alcohol dehydrogenase), CHS (chalcone synthase), flavanone 3-dioxygenase (F3H), ... 2010;49(1):202-204.. *103. Corbin C, Drouet S, Markulin L, Auguin D, Lainé É, Davin LB, et al. A genome-wide analysis of the ... 2014;15(1):1-13.. *106. Benedict CR, Liu J, Stipanovic RD, Ho O, C H, Oh HO, et al. The peroxidative coupling of hemigossypol ...

https://www.intechopen.com/chapters/75709

Dioxygenation of nitrobenzene to catechol and 2-nitrotoluene to 3-methylcatechol showed large C isotope enrichment factors, ϵC ... by nitrobenzene dioxygenase (NBDO) to obtain insights into the factors governing its C, H, and N isotope fractionation. ... Only α2-PBCDOH with the 1R,2R,5S,6R,9R,10S-configuration is obtained but not its enantiomer. With only two of the 64 PBCDOHs ... We predicted its stereochemistry to be 1E,5R,6R,9S,10R-PBCDE from docking experiments. The enzyme-substrate complex obtained ...

https://www.eawag.ch/de/ueber-uns/portraet/organisation/mitarbeitende/profile/hans-peter-kohler/show/

6. Dioxygenases without requirement for cofactors and their chemical model reaction: compulsory order ternary complex mechanism of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase involving general base catalysis by histidine 251 and single-electron oxidation of the substrate dianion. (nih.gov)
9. Vanadium aminophenolates in catechol oxidation: conformity with Finke's common catalyst hypothesis. (nih.gov)
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. (nih.gov)
use ACYLTRANSFERASES 1973-1979, use COENZYME A & PHOSPHOLIPIDS 1973-1978 MH - 1-Pyrroline-5-Carboxylate Dehydrogenase UI - D050842 MN - D8.811.682.662.693 MS - An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. (nih.gov)
HN - 2006(1983) MH - 2-Oxoisovalerate Dehydrogenase (Acylating) UI - D050645 MN - D8.811.682.657.350.825 MS - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. (nih.gov)
use ANTHRANILIC ACID 1974-1979 MH - 3-Isopropylmalate Dehydrogenase UI - D050539 MN - D8.811.682.47.500 MS - An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. (nih.gov)
In situ generation of Cu(I) species in the catalytic pathway of catechol oxidation was established by electrochemical study and further confirmed by electron paramagnetic resonance (EPR) spectroscopy. (ias.ac.in)

9/3/2005) TOTAL DESCRIPTORS = 935 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)
HN - 2006(1981) MH - 2-Aminoadipate Transaminase UI - D051307 MN - D8.811.913.477.700.120 MS - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipate onto 2-OXOGLUTARATE to generate 2-oxoadipate and L-GLUTAMATE. (nih.gov)
use AMINO ACIDS, BRANCHED-CHAIN 1979, & KETO ACIDS & VALERATES 1973-1979 MH - 3-Hydroxyanthranilate 3,4-Dioxygenase UI - D050561 MN - D8.811.682.690.416.328 MS - An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. (nih.gov)
use DICARBOXYLIC ACIDS 1970-1979 MH - 3-Phosphoshikimate 1-Carboxyvinyltransferase UI - D051229 MN - D8.811.913.225.735 MS - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and SHIKIMATE-3-PHOSPHATE. (nih.gov)
Both modeled enzyme-substrate complexes are in line with 1,2-diaxial HBr eliminations. (eawag.ch)
1 ] + has been evaluated as model system for the catechol oxidase enzyme by using 3,5- di -tert-butylcatechol (3,5-DTBC) as the substrate in methanol medium, which revealed that the cationic complex efficiently inhibits catalytic activity with k cat value 9.65 × 10 2 h −1 . (ias.ac.in)
The Cu(II) complex mimics the full catalytic cycle of the active site of catechol oxidase enzyme in acetonitrile medium with a turnover number of 4.788 × 10³ h⁻¹ along with the production of semiquinone radical and hydrogen peroxide. (ias.ac.in)

1996. Catechol 2,3-dioxygenases functional in oxygen-limited (hypoxic) environments. (nih.gov)

8. Iron(III) complexes of tripodal monophenolate ligands as models for non-heme catechol dioxygenase enzymes: correlation of dioxygenase activity with ligand stereoelectronic properties. (nih.gov)
We therefore hypothesized that the slow B degradation is determined by either a low catalytic efficiency of BD and DHBDH (the enzymes converting B to catechol) or maybe to a too high catalytic efficiency of them leading to an accumulation of catechol which can be toxic for the cell. (unito.it)
The ohp operon of Rhodococcus strain V49 consists of five genes, ohpR, ohpA, ohpB, ohpC and ohpD which encode putative regulator and transport proteins and confirmed monooxygenase, hydroxymuconic semialdehyde hydrolase and catechol 2,3-dioxygenase enzymes, respectively. (edu.sa)
These enzymes catalyse the conversion of 3-(2-hydroxyphenyl) propionic acid to the corresponding linear product via a meta-cleavage pathway. (edu.sa)

The bond parameters of 2(ox) and 3(ox) clearly establish the radical nature of catecholate- and o-aminophenolate-derived ligand, respectively. (unboundmedicine.com)

17. Novel iron(III) complexes of sterically hindered 4N ligands: regioselectivity in biomimetic extradiol cleavage of catechols. (nih.gov)
Complex 2 reacts with dioxygen to oxidatively cleave the aromatic C-C bond of DBC giving rise to selective extradiol cleavage products. (unboundmedicine.com)

4. Synthesis and characterization of V(V)(3,6-DBSQ)(3,6-DBCat)2, a d(0) metal complex with dioxygenase catalytic activity. (nih.gov)

14. Iron(III)-catecholato complexes as structural and functional models of the intradiol-cleaving catechol dioxygenases. (nih.gov)

RpoN (sigma 54) is required for conversion of phenol to catechol in Acinetobacter calcoaceticus. (cornell.edu)
Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250. (cornell.edu)
Kinetic analysis of A. radioresistens S13 growth shows that P (qp max = 53.8 Cmmol g-1 h-1, YX/phenol = 16.31 g/Cmol) is degraded faster and more efficiently than B (qb max = 49.3 Cmmol g-1 h-1, YX/benzoate = 9.79 g/Cmol). (unito.it)

Following biochemical assays of cell-free extracts from recombinant Escherichia coli expressing ohpB (monooxygenase), ohpC (hydroxymuconic-semialdehyde hydrolase) and ohpD (catechol 2,3-dioxygenase), the ortho-hydroxyphenylpropionic acid catabolic pathway in Rhodococcus strain V49 (ATCC 19070) has been predicted. (edu.sa)

4-Chlorocatechol 1,2-dioxygenase fromthe chlorophenol-utilizing Gram-positive Rhodococcus opacus1CP: crystallization and preliminary crystallographic analysis. (unifi.it)
Powell, JAC & Archer, J 1998, ' Molecular characterisation of a Rhodococcus ohp operon ', Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology , vol. 74, no. 1-3, pp. 175-188. (edu.sa)

These dihydroxylated intermediates may then be processed through either an ortho cleavage type of pathway, in which ring fission occurs between the two hydroxylated carbon atoms, or a meta- cleavage type of pathway, which involves cleavage of the bond adjacent to the hydroxyl groups, leading to central intermediates such as protocatechates and catechols. (europa.eu)
This iron(II)complex is able to catalyze the cleavage of aromatic C-C linkage of 2,5-dihydroxybenzoic acid (Gentisic acid, GA) in oxygen environment. (ias.ac.in)

Under aerobic conditions with toluene-induced cells, strains expressing toluene dioxygenases (Pseudomonas putida F1, Pseudomonas sp. (nih.gov)

2019). Other SNPs that have been studied in relation to thiopurine sensitivity are variants within the phosphoribosylglycinamide formyltransferase gene (involved in folate cycle), Molybdenum Cofactor Sulfurase gene (involved in thiopurine metabolism) and Protein Kinase C And Casein Kinase Substrate In Neurons 2 gene (involved in thiopurine metabolism (Smid et?al. (tache2016.org)

They are converted enzymatically to the natural intermediates of degradation, for example catechol and protecatechuate (Fritsche and Hofrichter, 2000). (europa.eu)

Table 2 Differential phenotypic characteristics between selleck kinase inhibitor strain IIH2T and related species Halopiger djelfamassiliensis strain IIH2T was susceptible to bacitracin (10 ��g), novobiocin (30 ��g) and tetracycline (30 ��g) but resistant to ampicillin (10 ��g), cephalothin (30 ��g), chloramphenicol (30 ��g), streptomycin (10 ��g), erythromycin (15 ��g), gentamicin (10 ��g), kanamycin (30 ��g), nalidixic acid (30 ��g), penicillin G (10 ��g) and vancomycin (30 ��g). (pkcpathway.com)
This in situ generated iron-GA adduct reacts with molecular oxygen at the rate, k obs = 6.58×10 −3 min −1 in acetonitrile and affords exclusively 2-oxo-4-hydroxy-hepta-3,5-dienedioic acid. (ias.ac.in)

3. Kinetic and mechanistic studies of vanadium-based, extended catalytic lifetime catechol dioxygenases. (nih.gov)
11. Monitoring supported-nanocluster heterogeneous catalyst formation: product and kinetic evidence for a 2-step, nucleation and autocatalytic growth mechanism of Pt(0)n formation from H2PtCl6 on Al2O3 or TiO2. (nih.gov)
Identification of bulk ruthenium metal as the true catalyst in benzene hydrogenations starting with the monometallic precursor, Ru(II)(eta 6-C6Me6)(OAc)2, plus kinetic characterization of the heterogeneous nucleation, then autocatalytic surface-growth mechanism of metal film formation. (nih.gov)

Structural characterisations of 1, 2, 2(ox) and 3(ox) reveal the presence of a strong iron-carbon bonding interaction in all the complexes. (unboundmedicine.com)
A mononuclear cobalt(II) complex, [Co(phen) ₂Cl ₂], (phen = 1,10-phenanthroline) has been synthesized and structurally characterized by different spectroscopic methods including single crystal X-ray structural study.X-ray crystal structural analysis revealed that the cobalt(II) complex crystallizes in amonoclinicsystem with C2/c space group and exists in cis-configuration in its crystalline state. (ias.ac.in)

who have generated two monoclonal antibodies (mAbs) against Epstein Barrs viral nuclear antigen I (EBNA-1), shown that these Abdominal muscles cross-react with double-stranded DNA (dsDNA).17 The seroprevalence of SARS-CoV-2 in HWs with this study was 0.58% (6/1036). (tache2016.org)

Co(phen) 2 Cl 2 ] + in methanol solution. (ias.ac.in)

HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)

12. Fine-tuning of catalytic properties of catechol 1,2-dioxygenase by active site tailoring. (nih.gov)

HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)

The lattice water molecules in 1 form a water-nitrate cluster, (H 2 O) 2 . (ias.ac.in)

Further, the anti-cancer activity of [ 1 ] + on human hepatocarcinoma cell line (HepG2) has been examined. (ias.ac.in)
The incorporation of both the oxygen atoms of molecular oxygen in the bio-mimicking activity of gentisate-1,2-dioxygenase by this iron(II)-phenanthroline complex remain arare example in scientific literature. (ias.ac.in)
Second of all, a patient with high immune activity (autoimmune disease) experienced autoantibodies that can cross-react with SARS-CoV-2 antigens and falsely give the impression of positive Abs. (tache2016.org)

where L(1) = tris(2-pyridylthio)methanido anion, DBC = dianionic 3,5-di-tert-butylcatecholate, and HAP = monoanionic 4,6-di-tert-butyl-2-aminophenolate) have been synthesised from an iron(II)-acetonitrile complex [L(1)Fe(II)(CH(3)CN)(2)](ClO(4)) (1). (unboundmedicine.com)
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
In this work, we have synthesised and crystallographically characterized a mononuclear iron(II) complex, [Fe(phen) 3 ](NO 3 ) 2 ·2H 2 O (1) (phen = 1,10-phenanthroline). (ias.ac.in)
NO 3 ) 2 through strong H-bonding interaction mediated via iron(II) complex in a unique binding motif and provide additional stability to the compound in the solid state. (ias.ac.in)

2 with a validated species enabled identification at the species level, and a score (pkcpathway.com)

Lancet 2(8052/8053): 1327-1328, December 24 and 31, 1977. (nih.gov)

Interestingly, the observed IC 50 values reveal that [ 1 ] + brings about conformational change on DNA strongly and exhibits remarkable cytotoxicity. (ias.ac.in)

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology , 74 (1-3), 175-188. (edu.sa)

Conclusions In conclusion, in this study, we shown that Rigosertib the two methods (CLIA and ELISA) for detecting anti-SARS-CoV-2 Abdominal muscles are AKT2 concordant. (tache2016.org)

The induction of apoptosis induced in the cell line was assessed base on the changes in cell morphology, which showed the efficacy of [ 1 ] + to induce apoptosis in 53% of cells during 24 h treatment. (ias.ac.in)

It was previously established that a double set of genes, one for B and the other for P catabolism, is present and two isozymes of catechol 1,2-dioxygenase (C1,2O) have been characterized. (unito.it)
Here, we present the XRD crystal structure of 1 E ,5 S ,6 S ,9 R ,10 S -pentabromocyclododecene (PBCDE) and demonstrate that its enantiomer with the 1 E ,5 R ,6 R ,9 S ,10 R -configuration is the only metabolite formed during LinA2-catalyzed dehydrobromination of (-)β-HBCD. (eawag.ch)

Single crystal X-ray diffraction (SXRD) analysis revealed that 1 crystallizes in monoclinic system with P 1 − space group. (ias.ac.in)

1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA. (nih.gov)

Moreover, this study indicated that 8 subjects (42%) were asymptomatic, suggesting asymptomatic healthcare staff could be an essential source of SARS-CoV-2 transmission. (tache2016.org)
Moreover, the exclusion of HWs who have been ill or quarantined during the study period may have led to an underestimation of SARS-CoV-2 seroprevalence. (tache2016.org)

Table 2 summarizes the differential phenotypic characteristics of H. djelfamassiliensis sp. (pkcpathway.com)

3-fluoro-2-hydroxy-6-oxohexa-2,4-dienoate = 1 reactions were found. (brenda-enzymes.org)
Thirdly, HWs in Thrace region were found to have a amazing low level of anti-SARS-CoV-2 antibodies, that is quite satisfying, reflecting the personal steps that they apply. (tache2016.org)

To investigate, a metagenomic characterization and metabolite profiling of ballast from U.S. Navy vessels with residence times of 1-, ~20-, and 31 weeks was conducted and compared with the seawater used to fill the tanks. (nature.com)
The patients in the MI group underwent whole-brain DTI and MEP measurements both before and 2 weeks Selonsertib nmr after the thalamic hematoma was evacuated by minimally invasive procedures. (mmp-signal.com)

2) An additional circular mapping catheter is required to increase complete isolation rate to 93% of the patients. (mmp-signal.com)

1 ] + cleaved pBR 322 DNA without addition of an activating agent. (ias.ac.in)

2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. (unifi.it)

Plant products, as food or as an "herbal medicine" preparation have been used by humans throughout history with varying success to prevent and/or cure various diseases [ 1 ]. (intechopen.com)
It is used in medicine (up to 5% in concentration) to treat dyschromias ( e.g. melasma, an acquired hypermelanosis) and in cosmetics (up to 2%) as a depigmenting agent in a number of topical skin creams. (nih.gov)

Organisms23

Diseases2

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes19

Disciplines and Occupations1

Information Science4

Health Care2

Catechols

Catechol 2,3-Dioxygenase

Dioxygenases

Catechol 1,2-Dioxygenase

Oxygenases

Estrogens, Catechol

4-Hydroxyphenylpyruvate Dioxygenase

Protocatechuate-3,4-Dioxygenase

Cysteine Dioxygenase

Tryptophan Oxygenase

Catechol O-Methyltransferase

Homogentisate 1,2-Dioxygenase

3-Hydroxyanthranilate 3,4-Dioxygenase

Pseudomonas

Biodegradation, Environmental

Kynurenine

Pseudomonas putida

Hydroxybenzoates

Rhodococcus

Phenol

Chlorobenzenes

Sorbic Acid

Catechol Oxidase

Tryptophan

Chlorobenzoates

Toluene

Benzoates

Mixed Function Oxygenases

Sphingomonas

Burkholderia

Substrate Specificity

Molecular Sequence Data

Benzoic Acid

Gentisates

Alcaligenes

Benzene

Adipates

Equilenin

Comamonas

Genes, Bacterial

Homogentisic Acid

Oxidation-Reduction

Acinetobacter

Pyrogallol

Brevibacterium

Hydrocarbons, Aromatic

Phenols

Ralstonia

Hydroquinones

Amino Acid Sequence

Planococcus Bacteria

Iron

Hydroxylation

Cloning, Molecular

Parabens

Polychlorinated Biphenyls

Gram-Negative Aerobic Rods and Cocci

Ferredoxins

Kinetics

Cresols

Burkholderiaceae

3-Hydroxyanthranilic Acid

gamma-Butyrobetaine Dioxygenase

Arthrobacter

Alkaptonuria

Xylenes

Ketoglutaric Acids

Biphenyl Compounds

Salicylates

Escherichia coli

Intramolecular Lyases

Ferrous Compounds

Toluidines

Enzyme Induction

ortho-Aminobenzoates

Vanillic Acid

Biotransformation

Bacterial Proteins

Sulfanilic Acids

Phenanthrenes