Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 126.96.36.199.
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 188.8.131.52 and EC 184.108.40.206.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Amino Acid Sequence
Gram-Negative Aerobic Rods and Cocci
A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Sequence Homology, Amino Acid
A species of gram-negative bacteria in the genus PSEUDOMONAS, containing multiple genomovars. It is distinguishable from other pseudomonad species by its ability to use MALTOSE and STARCH as sole carbon and energy sources. It can degrade ENVIRONMENTAL POLLUTANTS and has been used as a model organism to study denitrification.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Chromatography, High Pressure Liquid
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Sequence Analysis, DNA
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)
Gram-Negative Aerobic Bacteria
Gene Expression Regulation, Bacterial
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Nonheme Iron Proteins
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Gas Chromatography-Mass Spectrometry
Properties of catechol 1,2-dioxygenase in the cell free extract and immobilized extract of Mycobacterium fortuitum
... ... The catechol 1,2-dioxygenase of Mycobacterium fortuitum in the immobilized extract has greater stability to the variations of ... This study aimed to evaluate some environmental conditions that affect the production and activity of the catechol 1,2- ... This study aimed to evaluate some environmental conditions that affect the production and activity of the catechol 1,2- ...
3HHY | Genus
Dioxygenase_N. Catechol dioxygenase N terminus. Image from the rcsb pdb (www.rcsb.org) ... Aromatic compound dioxygenase. 3hhyA02. 2BUVA 3PCJM 3HGIA 3PCLM 1YKPA 3PCHA 3O5UA 2BUWB 3MI1A 2BUWA 3LXVM 3MV6M 2BUTB 3LMXM ... Catechol 1,2-dioxygenase publication title Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative ... Crystal structure determination of catechol 1,2-dioxygenase from rhodococcus opacus 1cp in complex with catechol ...
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Hou c.t., patel p., lillard m.o. extradiol cltavage of 3-methylcatechol by catechol 1,2-dioxygenase from various microorganisms ... 11(24), pages 1-26, december. What corporate security managers needs to know about hybrid warfare // . The goals are to ... 5(4), pages 1-12, november. Each flight carried two launchers; each containing three brimstone missiles alongside four amraam, ... You can heat high temperature framingham stove paint walsenburg by running the paint can under hot water for 2 minutes but be ...
Q84BZ1 | andAb - Domains and Structures | canSAR Black
Part of the multicomponent anthranilate dioxygenase, that converts anthranilate to catechol. This protein seems to be a 2Fe-2S ... Anthranilate 1,2-dioxygenase ferredoxin subunit - Also known as ANDAB_BURCE, andAb. ... Part of the multicomponent anthranilate dioxygenase, that converts anthranilate to catechol. This protein seems to be a 2Fe-2S ... Part of the multicomponent anthranilate dioxygenase, that converts anthranilate to catechol. This protein seems to be a 2Fe-2S ...
Chloridazon-catechol dioxygenase 220.127.116.11 Hydroxyquinol 1,2-dioxygenase 18.104.22.168 1-hydroxy-2-naphthoate 1,2-dioxygenase ... 3-dioxygenase 22.214.171.124 Persulfide dioxygenase 126.96.36.199 Cysteamine dioxygenase 188.8.131.52 Cysteine dioxygenase 184.108.40.206 ... 3-dioxygenase 220.127.116.11 Acireductone dioxygenase (Ni(2+)-requiring) 18.104.22.168 Acireductone dioxygenase (Fe(2+)-requiring) ... cleaving dioxygenase 22.214.171.124 9-cis-beta-carotene 9,10-cleaving dioxygenase 126.96.36.199 Carlactone synthase 188.8.131.52 All- ...
adipic acid synthesis mechanism
... and catechol 1,2-dioxygenase for a period of time sufficient to convert a carbon source to cis, cis-muconic acid and ... Lab 7 6 O H H α Step 1 O OH H Step 2 O OH OH Step 3 [O] [O] minus H 2O O O ket one α-h ydr x k et n gem-diol diketone O O ... adipic acid 1,6-diaminohexane H N N H H N O O O O N H Nylon 6,6 Figure 2: Nylon 6,6. Almost 90 percent of adipic acid produced ... R 1 = alkyl group; L = leaving group; The group -CH 2 CO 2 H in 2 is contributed by a malonic ester, hence the term malonic ...
BRENDA - 184.108.40.206: 3-carboxyethylcatechol 2,3-dioxygenase
3-dioxygenase. This is an abbreviated version!. For detailed information about 3-carboxyethylcatechol 2,3-dioxygenase, go to ... 3-dihydroxy-beta-phenylpropionic dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase, 3-(2,3-dihydroxyphenyl)propanoate: ... 2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate. + O2. = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. ... 2,3-dihydroxy-beta-phenylpropionate 1,2-oxygenase, 2,3-dihydroxy-beta-phenylpropionate oxygenase, 2, ...
Chloridazon-catechol dioxygenase is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-2.3-dihydroxyphenyl-32H...
Chloridazon-catechol dioxygenase is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-2.3-dihydroxyphenyl-32H- ... ⓘ Chloridazon-catechol dioxygenase. Chloridazon-catechol dioxygenase is an enzyme that catalyzes the chemical reaction ... ⓘ Chloridazon-catechol dioxygenase is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-2.3-dihydroxyphenyl-32H ... The oxygen incorporated need not be derived from O 2. The systematic name of this enzyme class is 5-amino-4-chloro-2-2.3- ...
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Catechol-O-Methyltransferase (COMT) gene is extensively investigated in depression with contradictory results but its ... 3-dioxygenase. Following its activation, both the production of neurotoxic compounds and the diminished peripheral ... Imola Plangar1, Zsofia Majlath1 and Laszlo Vecsei1,2. 1 Department of Neurology, University of Szeged, Hungary. 2 Neurology ... Dorottya Pap1, Gabriella Juhasz1,2 and Gyorgy Bagdy1. 1 Department of Pharmacodynamics, Semmelweis University, Budapest, ...
EP300 - Gentaur
Human COMT(Catechol-O-Methyltransferase) ELISA Kit. *Human COPT1(Copper Transporter 1) ELISA Kit ... This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the ... This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the ... Human IL1RAP(Interleukin 1 Receptor Accessory Protein) ELISA Kit. *Human IL1RAPL2(Interleukin 1 Receptor Accessory Protein Like ...
- Hou c.t., patel p., lillard m.o. extradiol cltavage of 3-methylcatechol by catechol 1,2-dioxygenase from various microorganisms. (brainee-trainee.com)
Incorporation of two atoms of oxygen1
- This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O 2 as oxidant and incorporation of two atoms of oxygen into the substrate oxygenases. (pp.ua)
- Thus, the two substrates of this enzyme are 5-amino-4-chloro-2-2.3-dihydroxyphenyl-32H-pyridazinone and oxygen, whereas its product is 5-amino-4-chloro-2-2-hydroxymuconoyl-32H-pyridazinone. (pp.ua)
- This study aimed to evaluate some environmental conditions that affect the production and activity of the catechol 1,2-dioxygenase (C12O) by Mycobacterium fortuitum in the cell free and immobilized extract in sodium alginate. (ufrgs.br)
- The catechol 1,2-dioxygenase of Mycobacterium fortuitum in the immobilized extract has greater stability to the variations of pH, temperature and reaction time, and show higher activity in presence of ions, comparing to the cell free extract. (ufrgs.br)