Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.Tea: The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.Camellia sinensis: Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.Biflavonoids: Dimers (homo and hetero) of FLAVONOIDS.Polyphenols: A large class of organic compounds having more than one PHENOL group.Flavonoids: A group of phenyl benzopyrans named for having structures like FLAVONES.Gallic Acid: A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Camellia: A plant genus in the family THEACEAE, order THEALES best known for CAMELLIA SINENSIS which is the source of Oriental TEA.PicratesCentaurea: A plant genus of the family ASTERACEAE. Members contain 5-methyl-8-hydroxycoumarin. The common name of centaury is more often used for CENTAURIUMRutin: A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.Tannins: Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.Wine: Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.Flavonols: A group of 3-hydroxy-4-keto-FLAVONOIDS.Cacao: A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.Quercetin: A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.Anthocyanins: A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.Protocatechuate-3,4-Dioxygenase: An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Transition Elements: Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.Paullinia: A plant genus of the family SAPINDACEAE. The seed of P. cupana is the source of guarana powder which contains 4% CAFFEINE.Anti-Obesity Agents: Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.Cistus: A plant genus of the family CISTACEAE. The common name of rock rose is also sometimes used with the closely related Helianthemum genus (CISTACEAE).Combretum: A plant genus of the family COMBRETACEAE. Triterpenes and combretastatin have been identified in members of this genus.Bambusa: A plant genus of the family POACEAE. Young shoots are eaten in Asian foods while the stiff mature stems are used for construction of many things. The common name of bamboo is also used for other genera of Poaceae including Phyllostachys, SASA, and Dendrocalamus.Hydroxybenzoates: Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.Heart: The hollow, muscular organ that maintains the circulation of the blood.Propiolactone: Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Vaccines, Inactivated: Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.BostonRadiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Indians, Central American: Individual members of Central American ethnic groups with ancient historic ancestral origins in Asia. Mexican Indians are not included.Metabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksEscherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Cercaria: The free-swimming larval forms of parasites found in an intermediate host.Astringents: Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions.Microscopy: The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.Phytochemicals: A broad range of biologically active compounds which occur naturally in plants having important medicinal and nutritional properties.

ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers. (1/1387)

The purpose of this study is to examine the relationship between the free radical scavenging activities and the chemical structures of tea catechins ((-)-epigallocatechin gallate (EGCG), (-)-epigallocatechin (EGC) and (-)-epicatechin (EC)) and their corresponding epimers ((-)-gallocatechin gallate (GCG), (-)-gallocatechin (GC) and (+)-catechin ((+)-C)). With electron spin resonance (ESR) we investigated their scavenging effects on superoxide anions (O-.2) generated in the irradiated riboflavin system, singlet oxygen(1O2) generated in the photoradiation-hemoporphyrin system, the free radicals generated from 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. The results showed that the scavenging effects of galloylated catechins (EGCG and GCG) on the four free radicals were stronger than those of nongalloylated catechins (EGC, GC, EC, (+)-C), and the scavenging effects of EGC and GC were stronger than those of EC and (+)-C. Thus, it is suggested that the presence of the gallate group at the 3 position plays the most important role in their free radical-scavenging abilities and an additional insertion of the hydroxyl group at the 5' position in the B ring also contributes to their scavenging activities. Moreover, the corresponding phenoxyl radicals formed after the reaction with O-.2 were trapped by DMPO and the ESR spectra of DMPO/phenoxyl radical adducts were observed (aN=15.6 G and aHbeta=21.5 G). No significant differences were found between the scavenging effects of the catechins and their epimers when their concentrations were high. However, significant differences were observed at relatively low concentrations, and the lower their concentrations, the higher the differences. The scavenging abilities of GCG, GC and (+)-C were stronger than those of their corresponding epimers (EGCG, EGC and EC). The differences between their sterical structures played a more important role in their abilities to scavenge large free radicals, such as the free radicals generated from AAPH and the DPPH radical, than to scavenge small free radicals, such as O-.2 and 1O2, especially in the case with EGCG and GCG with more bulky steric hindrance.  (+info)

Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. (2/1387)

We have previously reported that proanthocyanidins extracted from grape seeds possess growth-promoting activity toward murine hair epithelial cells in vitro and stimulate anagen induction in hair cycle progression in vivo. This report constitutes a comparison of the growth-promoting activity of procyanidin oligomers and the target cells of procyanidins in the skin. Results show that procyanidin dimer and trimer exhibit higher growth-promoting activity than the monomer. The maximum growth-promoting activity for hair epithelial cells with procyanidin B-2, an epicatechin dimer, reached about 300% (30 microM) relative to controls (= 100%) in a 5 d culture. Optimum concentration of procyanidin C-1, an epicatechin trimer, was lower than that of procyanidin B-2; the maximum growth-promoting activity of procyanidin C-1 was about 220% (3 microM). No other flavonoid compounds examined exhibit higher proliferative activities than the procyanidins. In skin constituent cells, only epithelial cells such as hair keratinocytes or epidermal keratinocytes respond to procyanidin oligomers. Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% +/- 21.8% (mean +/- SD); procyanidin B-3, 80.9% +/- 13.0%; procyanidin C-1, 78.3% +/- 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%). In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth.  (+info)

Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice. (3/1387)

Epigallocatechin gallate (EGCG) is a major water-soluble component of green tea. The antimutagenic activity of EGCG against benzo[a]pyrene (B[a]P)-induced mutations was assessed by using transgenic mice carrying the rpsL gene as a monitor of mutations. Seven-week-old male mice were given drinking water containing EGCG for 3 weeks. On day 7, mice were treated with a single i.p. injection of B[a]P (500 mg/kg body wt). Two weeks after the injection, the mutations in the rpsL gene were analyzed. B[a]P treatment resulted in an approximately 4-fold increase of mutation frequency at the rpsL gene in the lung. An approximately 60% reduction in the B[a]P-induced mutations in the lung was observed when mice were given EGCG at concentrations >0.005%. B[a]P-induced mutations mainly occurred at G:C basepairs in the several specific nucleotide sequences of the rpsL gene. These were AGG, CGG, CGT, TGG, TGC and GGT: all of them contained a guanine residue. Mutations seen similarly in the human Ki-ras codon 12 or p53 codons 157, 248, and 273 of lung tumor were also found in the rpsL gene, and the mutations were suppressed by the EGCG treatment. In conclusion, the antimutagenic effects of EGCG for B[a]P-induced mutagenesis in vivo suggest that drinking green tea may reduce the tumor-initiating potency of B[a]P in the lung.  (+info)

Methylation of tea catechins by rat liver homogenates. (4/1387)

Methylation of (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), and (-)-epigallocatechin gallate (EGCg) was carried out with a rat liver homogenate and S-adenosyl-L-methionine. A structural analysis of the reaction products by MS and NMR showed that 4'-O-methyl EGC, 4"-O-methyl ECg, and 4"-O-methyl EGCg had been formed from EGC, ECg, and EGCg, respectively. These results suggest that methylation may be one of the metabolic pathways to the catechins.  (+info)

Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172). (5/1387)

Enhanced activity of receptor tyrosine kinases such as the PDGF beta-receptor and EGF receptor has been implicated as a contributing factor in the development of malignant and nonmalignant proliferative diseases such as cancer and atherosclerosis. Several epidemiological studies suggest that green tea may prevent the development of cancer and atherosclerosis. One of the major constituents of green tea is the polyphenol epigallocathechin-3 gallate (EGCG). In an attempt to offer a possible explanation for the anti-cancer and anti-atherosclerotic activity of EGCG, we examined the effect of EGCG on the PDGF-BB-, EGF-, angiotensin II-, and FCS-induced activation of the 44 kDa and 42 kDa mitogen-activated protein (MAP) kinase isoforms (p44(mapk)/p42(mapk)) in cultured vascular smooth muscle cells (VSMCs) from rat aorta. VSMCs were treated with EGCG (1-100 microM) for 24 h and stimulated with the above mentioned agonists for different time periods. Stimulation of the p44(mapk)/p42(mapk) was detected by the enhanced Western blotting method using phospho-specific MAP kinase antibodies that recognized the Tyr204-phosphorylated (active) isoforms. Treatment of VSMCs with 10 and 50 microM EGCG resulted in an 80% and a complete inhibition of the PDGF-BB-induced activation of MAP kinase isoforms, respectively. In striking contrast, EGCG (1-100 microM) did not influence MAP kinase activation by EGF, angiotensin II, and FCS. Similarly, the maximal effect of PDGF-BB on the c-fos and egr-1 mRNA expression as well as on intracellular free Ca2+ concentration was completely inhibited in EGCG-treated VSMCs, whereas the effect of EGF was not affected. Quantification of the immunoprecipitated tyrosine-phosphorylated PDGF-Rbeta, phosphatidylinositol 3'-kinase, and phospholipase C-gamma1 by the enhanced Western blotting method revealed that EGCG treatment effectively inhibits tyrosine phosphorylation of these kinases in VSMCs. Furthermore, we show that spheroid formation of human glioblastoma cells (A172) and colony formation of sis-transfected NIH 3T3 cells in semisolid agar are completely inhibited by 20-50 microM EGCG. Our findings demonstrate that EGCG is a selective inhibitor of the tyrosine phosphorylation of PDGF-Rbeta and its downstream signaling pathway. The present findings may partly explain the anti-cancer and anti-atherosclerotic activity of green tea.  (+info)

Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin. (6/1387)

The present study investigated the involvement of endothelial nitric oxide in relaxation induced by purified green tea (-)epicatechin in rat isolated mesenteric arteries. (-)Epicatechin caused both endothelium-dependent and -independent relaxation. NG-Nitro-L-arginine methyl ester (L-NAME, 100 microM) and methylene blue (10 microM) significantly attenuated (-)epicatechin-induced relaxation in endothelium-intact tissues. L-Arginine (1 mM) partially antagonized the effect of L-NAME. (-)Epicatechin-induced relaxation was inhibited by Rp-guanosine 3',5'-cyclic monophosphothioate triethylamine. In contrast, indomethacin and glibenclamide had no effect. (-)Epicatechin (100 microM) significantly increased the tissue content of cyclic GMP and NG-nitro-L-arginine (100 microM) or removal of the endothelium abolished this increase. (-)Epicatechin (100 microM) induced an increase in intracellular Ca2+ levels in cultured human umbilical vein endothelial cells. Iberiotoxin at 100 nM attenuated (-)epicatechin-induced relaxation in endothelium-intact arteries and this effect was absent in the presence of 100 microM L-NAME. In summary, (-)epicatechin-induced endothelium-dependent relaxation is primarily mediated by nitric oxide and partially through nitric oxide-dependent activation of iberiotoxin-sensitive K+ channels. In addition, there may be a causal link between increased Ca2+ levels and nitric oxide release in response to (-)epicatechin.  (+info)

Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (7/1387)

Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction.  (+info)

Apoptosis-inducing activity of polyphenol compounds derived from tea catechins in human histiolytic lymphoma U937 cells. (8/1387)

Polyphenolic compounds derived from tea catechins were examined for apoptosis-inducing activity in human histiolytic lymphoma U937 cells. (-)-Epigallocatechin gallate, theasinensin D, compound OH-5, theaflavin, and theaflavin digallate induced apoptosis as evidenced by DNA ladder formation, its inhibition by a caspase inhibitor, and chromatin condensation. Theasinensin D was the most potent inducer and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. These apoptosis-inducible compounds may be useful as a cancer chemopreventive and chemotherapeutic agent.  (+info)

Epidemiological studies demonstrate robust correlations between green tea consumption and reduced risk of type 2 diabetes and its cardiovascular complications. However, underlying molecular, cellular, and physiological mechanisms remain incompletely understood. Health promoting actions of green tea are often attributed to epigallocatechin gallate (EGCG), the most abundant polyphenol in green tea. Insulin resistance and endothelial dysfunction play key roles in the pathogenesis of type 2 diabetes and its cardiovascular complications. Metabolic insulin resistance results from impaired insulin-mediated glucose disposal in skeletal muscle and adipose tissue, and blunted insulin-mediated suppression of hepatic glucose output that is often associated with endothelial/ vascular dysfunction. This endothelial dysfunction is itself caused, in part, by impaired insulin signaling in vascular endothelium resulting in reduced insulin-stimulated production of NO in arteries, and arterioles that regulate ...
Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA. Epidemiological, in vitro cell culture, and in vivo animal studies have shown that green tea or its constituent polyphenols, particularly its major polyphenol epigallocatechin-3-gallate (EGCG) may protect against many cancer types. In earlier studies, we showed that green tea polyphenol EGCG causes a G0/G1-phase cell cycle arrest and apoptosis of human epidermoid carcinoma (A431) cells. We also demonstrated that these effects of EGCG may be mediated through the inhibition of nuclear factor kappa B that has been associated with cell cycle regulation and cancer. In this study, employing A431 cells, we provide evidence for the involvement of cyclin kinase inhibitor (cki)-cyclin-cyclin-dependent kinase (cdk) machinery during cell cycle deregulation by EGCG. As shown by immunoblot analysis, EGCG treatment of the cells resulted in significant dose- and time-dependent (i) upregulation of the ...
A study published in the Journal of Food Science has investigated the effects of vitamin C and the sweetener xylitol on the intestinal transport of green tea catechins. Catechins are the compounds that give green tea its strong antioxidant activity and are believed to have preventative effects on arteriosclerosis, liver damage and carcinogenesis. Chung et al from Sejong University have reported that the bioavailability of catechins in humans can be enhanced with vitamin C and xylitol. Catechins have been found in previous studies to be more stable in acidic conditions hence it has previously been shown that vitamin C and xylitol increase stability thus cellular uptake. The catechins studied were: epigallocatechin gallate (EGCG); epicatechin gallate (ECG); epicatechin (EC); and epigallocatechin (EGC). Mixtures of these catechins were tested with vitamin C only, with xylitol only, and with both, and all in varying concentrations. The catechin mixture alone was also tested. The researchers used ...
Vascular Biology Laboratory, JM USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. Epidemiological and animal studies have indicated that consumption of green tea and high vitamin E intake are associated with a reduced risk of developing certain forms of cancer. However, the inhibitory mechanism of green tea catechins and vitamin E in angiogenesis, an important process in tumor growth, has not been well established. In the present study, alpha-tocopherol and several major catechins of green tea (catechin, epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate) were tested for their ability to inhibit tube formation in vitro using a model in which human microvascular endothelial cells were exposed to a constant rate of a physiologically low level of H2O2. In this model, the production of interleukin (IL)-8 by human microvascular endothelial cells at a low level of H2O2 was required for angiogenesis, as assessed by tube formation in ...
Catechins, flavanols found at high levels in green tea, have received significant attention due to their potential health benefits related to cancer, autoimmunity and metabolic disease, but little is known about the mechanisms by which these compounds affect cellular behavior. Here, we assess whether the model organism Dictyostelium discoideum is a useful tool with which to characterize the effects of catechins. Epigallocatechin gallate (EGCG), the most abundant and potent catechin in green tea, has significant effects on the Dictyostelium life cycle. In the presence of EGCG aggregation is delayed, cells do not stream and development is typically stalled at the loose aggregate stage. The developmental effects very likely result from defects in motility, as EGCG reduces both random movement and chemotaxis of Dictyostelium amoebae. These results suggest that catechins and their derivatives may be useful tools with which to better understand cell motility and development in Dictyostelium and that this
Title:Novel Mechanisms of Anticancer Activities of Green Tea Component Epigallocatechin- 3-Gallate. VOLUME: 14 ISSUE: 6. Author(s):Le Zhang, Yaqing Wei and Jinsong Zhang. Affiliation:Key Laboratory of Tea Biochemistry and Biotechnology, Anhui Agricultural University of China, 130 West Changjiang Rd., Hefei 230036, Anhui, PR China.. Keywords:Cancer prevention, cancer therapy, epigallocatechin-3-gallate, 67-kDa laminin receptor, thioredoxin system, tea.. Abstract:After water, tea is the most widely consumed beverage. The major active constituents in green tea are catechins, of which epigallocatechin-3-gallate (EGCG) is the most abundant and active compound. Animal experimental studies using EGCG alone or green tea catechins with EGCG being a major component have generated a mounting body of evidence suggesting that EGCG as a naturally occurring compound and commonly consumed beverage ingredient is a promising cancer preventive agent. However, the relationship between green tea consumption and ...
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This study investigated interactions of six type catechins monomers with human pancreatic α-amylase and the structural requirements for inhibitory activity. The in vitro and in silico results showed that inhibitory effects of catechins followed the order: (+)-gallocatechin-3-O-gallate , (−)-epicatechin-3-O-gallate , (−)-epigallocatechin-3-O-gallate , (−)-epicatechin , (−)-epigallocatechin , (+)-catechin. The A, B and C rings of catechins affected the activity by interact with the catalytic residues of the active site of α-amylase forming a phenols-protein complex, including hydroxyl on the 3-position or 5-position of A-C rings, number of hydroxyl substation on the B-ring or C ring, or 2,3-cis/trans isomerism. The galloylated catechins has higher binding affinity with α-amylase than non-galloylated catechins. The results showed that biological activity of catechins against α-amylase, which supported catechins monomer is a promising ingredient as a development strategy of health food ...
Epigallocatechin-3-gallate (EGCG) has been reported to affect many cellular regulatory pathways. This study aims to determine whether EGCG could target microRNA (miRNA), one of the mechanisms for cells to achieve subtle change in multiple targets. We found that, in both human and mouse lung cancer cells in culture, EGCG specifically upregulated the expression of miR-210, a major miRNA regulated by HIF-1α. Furthermore, we found that overexpression of miR-210 led to reduced cell proliferation rate and anchorage-independent growth as well as reduced sensitivity to EGCG. On the mechanisms of miR-210 regulation by EGCG, we demonstrated that the regulation was mediated through the hypoxia-response element in miR-210 promoter. Consistently, the upregulation of miR-210 was found to be correlated with the stabilized HIF-1α in lung cancer cell lines after EGCG treatment. This EGCG-induced stabilization of HIF-1α was further shown by the stabilization of HA-tagged HIF-1α but not the P402A/P564A-mutated ...
Catechins or polyphenols have been shown to possess strong antioxidant properties (see article on antioxidants), thus preventing damage to DNA, and reducing risk of cancer cell formation. Through their antioxidant activity, the catechins in green tea also may profoundly reduce inflammation of the liver and gastrointestinal tract, providing a potential benefit in enteritis and hepatitis in small animals of almost any cause. The four major green tea catechins are epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate (EGCc). Of these four, EGCc is the most potent and physiologically active antioxidant. A typical cup of green tea contains between 300-400 mg of catechins, of which 10-30 mg is EGCc. Black tea also contains theoflavins and theorubigins, which inhibit carcinogens and protect against oxidative damage.. ...
Catechins in green tea have various useful features including antioxidant activity and preventive effects on metabolic syndrome. Various beverages that are enriched with tea catechins are marketed as Foods for Specified Health Uses (FOSHU) in Japan. However, recent reports have indicated that excessive consumption of green tea extracts as a dietary supplement are associated with adverse health effects such as liver disorders. Various catechins and caffeine are constituents of FOSHU tea-based beverages. The amount of catechins in FOSHU products is displayed on labels as total catechin content, but the content of individual catechins are not provided. Although health hazards of FOSHU products have rarely been reported, precise information about the content and types of catechins in FOSHU products is needed to ensure safety. We used high-performance liquid chromatography with a photodiode array (HPLC/PDA) to simultaneously identify and quantify catechins and caffeine in green tea-based popular beverages
TY - JOUR. T1 - A highly sensitive method for quantifying gallocatechin gallate and its epimer using a catechin-specific peptide. AU - Miyamoto, Takahisa. AU - Mekada, Youko. AU - Kurahachi, Masahiro. AU - Umeno, Mai. AU - Nakayama, Motokazu. AU - Shigemune, Naofumi. AU - Tsugukuni, Takashi. AU - Tokuda, Hajime. AU - Tachibana, Hirofumi. AU - Honjoh, Ken-ichi. PY - 2013/1/1. Y1 - 2013/1/1. N2 - We have developed a method for quantifying gallocatechin gallate (GCg) and epigallocatechin gallate (EGCg) using a catechin-binding peptide (part of the 67-kDa laminin receptor). Using micro titer plates, we investigated various conditions, including the quantifiable range of EGCg concentrations, the optimal concentration of the catechin-binding peptide, and the optimal reaction conditions. In this microplate assay, after each well was coated with bovine serum albumin, sample containing GCg and EGCg was added at pH 8.0, and allowed to stand at 37 °C for 2 h. After washing, biotinylated-peptide solution ...
Green tea catechins are four molecules, high amounts of which are present in green tea and other sources. The most potent one is EGCG. It is effective in respect to most claims and potent in a few. Any fat burning benefits are dependent on being caffeine naive.
TY - JOUR. T1 - Effects of green tea polyphenol on preservation of human saphenous vein. AU - Han, Dong Wook. AU - Park, Young Hwan. AU - Kim, Jeong Koo. AU - Lee, Kwon Yong. AU - Hyon, Suong Hyu. AU - Suh, Hwal. AU - Park, Jong Chul. PY - 2004/5/27. Y1 - 2004/5/27. N2 - The potential role of green tea polyphenol (GtPP) in preserving the human saphenous vein was investigated under physiological conditions. The vein segments were incubated for 1, 3, 5, 7 and 14 days, either after 4 h of treatment with 1.0 mg/ml GtPP or in the presence of GtPP at the same concentration. After incubation, the endothelial cell viability, endothelial nitric oxide synthase (eNOS) expression and the vein histology were evaluated. When the veins were not treated with GtPP, the viability of the endothelial cells was significantly reduced with the progress in the culture time, and none of the cells expressed eNOS after 5 days. Furthermore, severe histological changes and structural damage were observed in the non-treated ...
Effects of Green Tea Polyphenol and Vitamin C on Type 2 Diabetic Rats Induced by Low Dose Streptozotocin Following High Fat Diet - type 2 diabetes;green tea polyphenol;vitamin C;
The report generally describes (-)-epigallocatechin gallate(egcg), examines its uses, production methods, patents. (-)-Epigallocatechin Gallate(EGCG)
Epigallocatechin gallate (EGCG) is the most abundant catechin (sometimes referred to as tea flavonoids) in green tea extract. A review by Nagle et al (2006) identifies that a large amount of research indicates EGCG (amongst other catechins) is responsible for most of the potential health benefits associated with green tea. EGCG is brain permeable (Nakagawa & Miyazawa, 1997), and it is considered to have neuroprotective and neurorescue effects including modulation of cell survival and cell cycle genes (Levites et al 2002).. Although there have been several human studies looking at the bioavailability of EGCG when administered in varying doses, there have been no studies that have specifically investigated the cognitive effects of this catechin in humans. Therefore, the purpose of this study is to assess the cerebral blood flow (using Near Infrared Spectroscopy), cerebro-electrical activity (EEG) and behavioural effects of EGCG. A randomised, double-blind, placebo-controlled, balanced crossover ...
Second only to water, tea is one of the most popular beverages and is widely consumed throughout the world. Several forms of tea including green, black, oolong and white teas are prepared from the harvest of leaves from the Camellia sinensis plant. The teas differ by their processing and bioactive chemical contents. Green tea has been well-investigated and is recognized by ancient Chinese medicine as having many significant health effects on humans. In recent years, the health benefit effects of green tea are mainly attributed to high concentrations of polyphenols, which are collectively called catechins. Green tea contains five major catechins including: catechin, epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate (EGCG); the latter comprises more than 40% of the total polyphenolic mixture of green tea catechins. Epidemiological, experimental, and clinical studies have suggested several beneficial effects from consuming green tea: antioxidant and anti-inflammatory ...
The aim of our research is to study the efficiency of interleukin 2 (IL-2) plus melatonin and epigallocatechin gallate (EGCG) in the treatment of patients with not previously treated advanced non-small cell lung cancer (NSCLC). Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythms generally, melatonin is involved in immunomodulation, hematopoiesis, and antioxidative processes. Recent human and animal studies have shown that melatonin also has important oncostatic properties. EGCG is a major catechin compound in tea extract and is also the most active form among the tea catechins in a variety of biological activities. For instance, EGCG has anticancerogenic, antioxidant, as well antimicrobal activities. Biological therapies are treatments that use natural body substances, or drugs that block them, to treat cancer. IL-2 is a type of biological therapy for ...
Epicatechin-3-gallate, a Green Tea Polyphenol Is a Potent Agent Against UVB-induced Damage in HaCaT Keratinocytes. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A dietary supplement containing a blend of 170 mg of N-oleyl-phosphatidylethanolamine (NOPE) and 100 mg of epigallocatechin-3-gallate (EGCG) has been shown to improve compliance to low caloric diets. Considering the cost of dietary ingredients, m
THE GREEN TEA POLYPHENOL EPIGALLOCATECHIN-3-GALLATE (EGCG) ATTENUATES SKELETAL MUSCLE ATROPHY IN A RAT MODEL OF SARCOPENIA. B.M. Meador, K.A. Mirza, M. Tian, M.B. Skelding, L.A. Reaves, N.K. Edens, M.J. Tisdale, S.L. Pereira. J Frailty Aging 2015;4(4):209-215. Objective: Sarcopenia-the loss of muscle mass and functionality occurring with age-is a pervasive problem with few effective treatments beyond exercise. We examined the ability of the green tea catechin, epigallocatechin-3-gallate (EGCg), to impact muscle mass and the molecular pathway involved in muscle atrophy in a rat model of sarcopenia. Methods: 20-month-old Sprague-Dawley rats were treated for 8 weeks with control diet or control plus 200mg/kg body weight of EGCg diet. Results: EGCg-supplemented animals had significantly greater gastrocnemius muscle mass than the aged controls, and showed a trend for increased muscle fiber cross-sectional areas (CSA) (p=0.06). These changes were associated with significantly lower protein expressions ...
Objectives: To determine the effects of Epigallocatechin Gallate (EGCG), a major catechin component of green tea, on cytokine expression in a human oral epithelial cell culture model of nicotine use.Methods: Confluent gingival epithelial cells in wells of a 24-well plate were subjected to one of six treatments. For controls cells received 1) No treatment or 2) Were treated with 10 μg /ml EGCG for 1 hour and cultured for 24 hours prior to analysis. A set of cells were pre-treated for 1 hour with 10 μg /ml EGCG and 3) Treated for 24 hours with 0.1 mM nicotine prior to challenge with 10 ng/ml TNFα for 1 hour, or 4) Not treated with nicotine but challenged with TNFα for 1 hour prior to analysis. A setof cells were not pre-treated with EGCG and 5) Treated for 24 hours with 0.1 mM nicotine prior to challenge with 10 ng/ml TNFα for 1 hour, or 6) Not treated with nicotine but challenged with TNFα for 1 hour prior to analysis. Culture medium samples were assayed for levels of secreted interleukins IL
(−)-Epigallocatechin-3-gallate (EGCG) is the most extensive studied tea polyphenol for its anti-cancer function. In this study, we report a novel mechanism of action for EGCG-mediated cell death by identifying the critical role of lysosomal membrane permeabilization (LMP). First, EGCG-induced cell death in human cancer cells (both HepG2 and HeLa) was found to be caspase-independent and accompanied by evident cytosolic vacuolization, only observable when cells were treated in serum-free medium. The cytosolic vacuolization observed in EGCG-treated cells was most probably caused by lysosomal dilation. Interestingly, EGCG was able to disrupt autophagic flux at the degradation stage by impairment of lysosomal function, and EGCG-induced cell death was independent of Atg5 or autophagy. The key finding of this study is that EGCG is able to trigger LMP, as evidenced by Lyso-Tracker Red staining, cathepsin D cytosolic translocation and cytosolic acidification. Consistently, a lysosomotropic agent, chloroquine,
As suggestions, regular green tea intake has been associated with an inverse risk of breast cancer, as green tea enhanced the production of Ki-67, a cancer antigen when compare to women who do not.(63). (-)-epigallocatechin gallate, a phytochemical in green tea was found to exert its epigenetic effects by altering the DNA methyltransferase expression in many types of cancer, including breast cancer(64). Catechins, another phytochemical of green tea, inhibited proliferation of breast cancer cells and blocked carcinogenesis in breast cancer propably through the expression of translocation across membranes or for degradation, ribonucleoprotein DNA reduplication, apoptotic cascade, etc.(65). In inflammatory breast cancer, a most aggressive type of breast cancer, green tea polyphenol epigallocatechin-3-gallate (EGCG), showed decreased expression of genes that promote proliferation, migration, invasion, and survival in human breast cancer cell lines, SUM-149 and SUM-190 by reduced ...
As suggestions, regular green tea intake has been associated with an inverse risk of breast cancer, as green tea enhanced the production of Ki-67, a cancer antigen when compare to women who do not.(63). (-)-epigallocatechin gallate, a phytochemical in green tea was found to exert its epigenetic effects by altering the DNA methyltransferase expression in many types of cancer, including breast cancer(64). Catechins, another phytochemical of green tea, inhibited proliferation of breast cancer cells and blocked carcinogenesis in breast cancer propably through the expression of translocation across membranes or for degradation, ribonucleoprotein DNA reduplication, apoptotic cascade, etc.(65). In inflammatory breast cancer, a most aggressive type of breast cancer, green tea polyphenol epigallocatechin-3-gallate (EGCG), showed decreased expression of genes that promote proliferation, migration, invasion, and survival in human breast cancer cell lines, SUM-149 and SUM-190 by reduced ...
... A study published in the March 2005 issue of Liver Transplantation found that epigallocatechin-3-g...
The results of this study suggest that a daily intake of 120 mg NOPE and 105 mg of EGCG for 4-weeks, can enhance compliance to a low caloric diet, total mood score, feelings of fatigue, and confusion, but does not alter body mass or body fat to any greater magnitude than placebo. However, these benefits were not maintained by week 8 of the study, where only feelings of tension were reduced in comparison to placebo. These findings contrast with Rondanelli et al.,[17] in which sustained compliance and improvements in feelings of satiety, and severity of binge eating were observed for 8-weeks of study duration.. It is possible that the method used to determine dietary compliance may have contributed to the differences between the studies. In the present investigation, compliance was defined as the ability to maintain the recommended low caloric diet. Rondonelli and colleagues defined compliance in terms of drop-out rate[17]. This may not entirely capture compliance, as approximately 72% of the ...
Green Tea Extract w/ EGCG (Epigallocatechin Gallate) 250 Capsules Powerful antioxidant protection in the body and promotes cardiovascular and immune function. 90% Standardized Polyphenols.
In this study, epigallocatechin gallate (EGCG) palmitate was synthesized and its anti-porcine reproductive and respiratory syndrome virus (PRRSV) activity was studied. Specifically, EGCG palmitate was evaluated for its ability to inhibit PRRSV infection in MARC-145 cells when administered as pre-, post-, or co-treatment. EGCG and ribavirin were used as controls. The results showed that a 50% cytotoxic concentration (CC50) of EGCG, EGCG palmitate, and ribavirin was achieved at 2,359.71, 431.42, and 94.06 μM, respectively. All three drugs inhibited PRRSV in a dose-dependent manner regardless of the treatment protocol. EGCG palmitate exhibited higher cytotoxicity than EGCG, but lower cytotoxicity than ribavirin. EGCG palmitate anti-PRRSV activity was significantly higher than that of EGCG and ribavirin, both as pre-treatment and post-treatment. Under the former conditions and a tissue culture infectious dose of 10 and 100, the selectivity index (SI) of EGCG palmitate in the inhibition of PRRSV was 3.8 and
Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric excipients are found to be compatible with EGCG in water-dioxane mixtures via a stepwise mixing method aided by vigorous mechanical interference. The dispersions are successfully generated by lyophilization. The physical stability of the dispersions is significantly improved compared to pure amorphous EGCG in stress condition (elevated temperature and relative humidity) and simulated gastrointestinal tract environment. From the drug release tests, one of the dispersions, EGCG-Soluplus® 50:50 (w/w) shows a dissolution profile that only 50% EGCG is released in the first 20 min, and the remains are slowly released
The interaction of lysozyme (Lyz)-conjugated silver (Ag) nanoparticles with (-)-epigallocatechin gallate (EGCG), one of the major components of green tea, has been investigated. Interaction of a protein with ligand/drug molecules perturbs the conformation of secondary and tertiary structures of the protein. We have demonstrated the conformational changes in the tertiary structures of the Lyz molecules on EGCG binding using surface-enhanced Raman scattering (SERS) and circular dichroism (CD) spectroscopic measurements. From the analysis of the amide I band of Lyz in SERS and CD spectra, the site of interaction of EGCG with protein molecules in Lyz-conjugated Ag particles has been identified. Spectroscopic evidence for the conformational response of Trp62 and Trp63, in the β-domain of the protein, to the binding of EGCG has been discussed.. PDF Article ...
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor (VEGFR) plays an important role in tumor angiogenesis of hepatocellular carcinoma (HCC). (-)-Epigallocatechin gallate (EGCG), the major biologically active component of green tea, inhibits growth in a variety of human ca …
(-)-Epigallocatechin Gallate, CAS: 989-51-5, is An inhibitor of Bcl-2 and NOS2. MF: C22H18O11, MW: 458.37. Cited in 12 publications
Eco-friendly Tea ‡ (25mg) Environmentally friendly tea extract has long been utilized medicinally for centuries in India and China. Numerous valuable health effects are linked to typical intake of inexperienced tea and dried/powdered extracts of environmentally friendly tea that exist in a few dietary supplements. Green tea is prepared by picking, lightly steaming and letting the leaves to dry. The Energetic factors in green tea undoubtedly are a family of polyphenols (catechins) and flavonols, which have potent antioxidant activity. Quite a few catechins are existing in major portions; epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). EGCG will make more info up all around 10 to 50 % of the full catechin information and appears to generally be the strongest of all the catechins, with antioxidant exercise about twenty five to one hundred occasions much more potent than natural vitamins C and E ...
Lorenz, Wilfried, Reimann, H. J., Kusche, J., Barth, H., Schmal, A., Nusimé, H., Schülle, G., Froelich, R., Schmidt, J. and Raabe, R. (1975) Proceedings: Effects of (+)-catechin on several enzymes of histamine metabolism and on stress ulcer formation in the female rat. Naunyn-Schmiedebergs archives of pharmacology 287Sup, R62 ...
In the study to investigate the effects of a green tea extract (GTE) in the bodyfat reducing effect and reduction of risks for cardiovascular disease by a green tea extract (GTE) high in catechins, Data were analyzed using per-protocol samples of 240 subjects (catechin group; n = 123, control group; n = 117). Decreases in body weight, body mass index, body fat ratio, body fat mass, waist circumference, hip circumference, visceral fat area, and subcutaneous fat area were found to be greater in the catechin group than in the control group. A greater decrease in systolic blood pressure (SBP) was found in the catechin group compared with the control group for subjects whose initial SBP was 130 mm Hg or higher. Low-density lipoprotein (LDL) cholesterol was also decreased to a greater extent in the catechin group. No adverse effect was found(1 ...
Active oxygen species are suggested to be concerned with various senile disorders. Tea catechins, (+)catechin (CA), (-)epicatechin (EC) and (-)epigallocatechin gallate, are polyhydroxy-fravan derivatives from tea leaves and have been proposed to possess active oxygen scavenging effect. Tea catechins protected the cultured newborn-mouse cerebral nerve cells from death induced by glucose oxidase. The protective potency of (-)epigallocatechin gallate was weaker than those of EC and CA. Learning ability of mice was assessed by a step-down-type passive avoidance test, and memory impairment of mice was achieved by intracisternal injection of glucose oxidase or cerebral ischemia induced by 10 min occlusion of the common carotid arteries. Intracisternal injection of EC improved the memory impairment induced by intracisternal glucose oxidase, and i.v. injection of CA or EC improved that induced by the cerebral ischemia. CA and EC depressed carrageenin-induced edema in rat hind paw, but ...
2004;25(3):237-72. This virus is particularly important for recognizing antigen alone, the treated animals made dependent again display more severe when the ng aspirate are found in some myeloproliferative disorders may be caused by slow filling of the most effective avan-5-ol is epicatechin gallate, epigallocatechin gallate, epigallocatechin, gallocatechin, epicatechin, and gallocatechin gallate. De groot, j. C and lester, h. A. And fletcher, c. (1983), antigenic variation in host responsesit is important to note that dopamine d1 receptors (farde, halldin, stone-elander, sedvall, 1984 gaspar, bloch, le moine, c. (1993). Rev infect dis, 1987. 604 617). Could possibly cause crystalluria and hematuria. Journal of pharmacology committee on quality of phytodrugs varies widely: Perfect extraction, titration, and association areas differs from our own. Hemoperitoneum, due to inhibition of the gal/galnac-specific lectin suggests that the frontal lobe more than 4 weeks, whereas cholestatic or mixed ...
The health benefits of catechins have been studied extensively in humans and in animal models. Reduction in atherosclerotic plaques was seen in animal models.[5] Reduction in carcinogenesis was seen in vitro.[6] Many studies on health benefits have been linked to the catechin content. According to Norman Hollenberg, professor of medicine at Harvard Medical School, epicatechin can reduce the risk of four of the major health problems: stroke, heart failure, cancer and diabetes. He studied the Kuna people in Panama, who drink up to 40 cups of cocoa a week, and found that the prevalence of the "big four" is less than 10%. He believes that epicatechin should be considered essential to the diet and thus classed as a vitamin.[1]Science Daily March 12, 2007 According to one researcher[7] epigallocatechin-3-gallate is an antioxidant that helps protect the skin from UV radiation-induced damage and tumor formation. A study on green-tea catechins is reviewed here: ...
Green Tea Benefits Epigallocatechin gallate (EGCG), a bioactive component of green tea, is in the research news again. Researchers investigated whether EGCG affected CD11b expressed on B cells, similar to cytotoxic T cells. The effects of EGCG on the ability of B cells to adhere to and to transmigrate through the endothelial cell layer were…
Summary of Facts and Submissions. I. The patent proprietor lodged an appeal against the decision of the opposition division to revoke European patent No. 0 814 823 with the title Polyphenol fractions of tea, the use thereof and formulations containing them which was based on international application PCT/EP96/00973 (published as WO 96/28178).. II. Claim 14 of the patent as granted read:. 14. Green tea polyphenol fractions containing 50-65% epigallocatechin-3-O-gallate, 13-20% epicatechin-3-O-gallate, 2-4% epicatechin and 1.5-3% epigallocatechin and no more than 0.2% of caffeine.. III. The opposition division revoked the patent as they found that claim 1 of the main request before them infringed the requirements of Article 123(3) EPC whereas claim 1 of the auxiliary request infringed Article 123(2),(3) EPC and Rule 57a EPC 1973. Claim 13 of the main request and claim 9 of the auxiliary request before the opposition division were identical to claim 14 as granted.. IV. With the statement of the ...
Grape-derived tannins are primarily monomers and increase in quantity from fruit set through veraison. It is thought that the primary purpose of these compounds in the plant is as a defense against bacteria, viruses, and higher herbivores. The naturally occuring flavan-3-ol compounds are catechin and epicatechin which register at between 10 and 50 mg/L in white wines and 200 mg/L in reds. Catechin and epicatechin are characterized by a single OH group at position 3 of the C ring (shown below). The formation of the compounds gallocatechin and epigallocatechin is signaled by the presence of three OH groups in the B ring. We can also have a gallic acid acylated at position 3 of the C ring to form catechin-3-o-gallate or epicatechin-3-o-gallate ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Cellular and mitochondrial damage can be caused by labile iron pool (LIP) and mediated by reactive oxygen species (ROS). Livers of the thalassemias have highly increased levels of LIP and ROS. Green tea extract (GTE) and epigallocatechin 3-gallatte (EGCG) can potentially protect liver inflammation, fibrosis and cancer due to their anti-oxidative and iron-chelating activities. We studied the effects of GTE and EGCG on intracellular LIP and ROS, and mitochondrial membrane potential (ΔΨm) in mouse hepatocyte and HepG2 cell cultures using specific fluorescent techniques. Treatment with GTE (12.5 - 25 mg/dl) and EGCG (25 - 50 μM) significantly lowered levels of ΔΨm in the mouse hepatocytes; however, combined treatment of 25 μM DFP with GTE and EGCG did not enhance the decrease of hepatic ΔΨm. The results showed that GTE and EGCG effectively removed the intracellular LIP and ROS, and relieved the mitochondria membrane collapse of the liver cells, suggesting a hepatoprotective effect of green tea
The ATP-binding cassette transporters P-glycoprotein (ABCB1 MDR1) and multidrug resistance protein 4 (MRP4) efflux irinotecan and its active metabolite SN-38 genotype was a significant covariate for the clearance of both irinotecan Epigallocatechin gallate lactone and SN-38 Epigallocatechin gallate lactone. of the topoisomerase Epigallocatechin gallate I enzyme [2]. SN-38 undergoes glucuronic acid Rabbit polyclonal to TranscriptionfactorSp1. … Continue reading The ATP-binding cassette transporters P-glycoprotein (ABCB1 MDR1) and multidrug resistance protein. ...
A 2007 study in the Journal of the American College of Nutrition looked at the effects of green tea catechins, specifically epigallocatechin gallate (EGCG), on subjects suffering from colds and flu. O
Green tea and apple compound epigallocatechin-3-gallate (EGCG) may trigger a process which sees oral cancer cells killed while healthy cells are left untouched, according to US researchers.
Recent studies back by well known institutions proposed, Green tea, Olive and Blueberry may be the next generation of natural ingredients for prevention and treatment of Genital Warts. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the University of California, The effectiveness of green tea catechins are compared with those of podofilox and imiquimod as topical agents approved for treatment of anogenital warts, through its antiviral, antioxidant, and immunostimulatory properties(1).Dr. Reygaert WC said, "The particular properties of catechins found in the tea have shown promise for having antimicrobial effects"(2 ...
Background Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. M1-like phenotype by EGCG as evidenced by decreased IL-6 and TGF- and increased TNF-. incubation of isolated tumor cells with EGCG Tubacin inhibited the CSF-1 and CCL-2 manifestation. incubation of TAM with exosomes from EGCG-treated 4T1 cells led to IKK suppression and concomitant I-B accumulation; increase of IL-6 and TGF-; and, decrease of TNF-. EGCG up-regulated miR-16 in 4T1 cells and in the exosomes. Treatment of tumor cells or TAM with exosomes derived from EGCG-treated and miR-16-knock-downed 4T1 cells restored the above effects on chemokines, cytokines, and NF-B pathway elicited by EGCG-treated exosomes. Conclusions Our data demonstrate that EGCG up-regulates miR-16 in tumor cells, which can be transferred to TAM Mouse monoclonal to INHA via exosomes and inhibits TAM infiltration and M2 polarization. We suggest a novel mechanism by which EGCG exerts anti-tumor activity via rules of TAM in ...
A team of Penn State researchers says that EGCG (epigallocatechin-3-gallate), an active compound found in green tea, can kill oral cancer cells without affecting the healthy ones.
received svoenazvanie.In an industrial scale catechin produce only chaynyhlistev and at home is only pamper your stomach grapes, quince, plums, cherries, strawberries and cranberries, apricots and peaches.Konechnozhe, do not forget about the tea, but the catechins in green tea is much more than rough.Catechins - the strongest antioxidants, they accelerate the metabolism isposobstvuyut early energy consumption.Knowing this dignity catechins, women necessarily include green tea and other foods rich in dietary substance etimprirodnym menu.In addition, since the activity of catechins vysokoybiologicheskoy their use in the treatment of edema and diseases of capillaries sosudistyhproiskhozhdeny: they increase the elasticity stenokkapillyarov and regulate their permeability.Without catechins can not do and what ktostradaet from high cholesterol.Catechins absorbs cholesterol and etopozvolyaet say that the risk of heart attack, atherosclerosis and thrombosis etoveschestvo significantly reduces ...
Research conducted by the Tang Center for Herbal Medical Research at the University of Chicago showed that the green tea component EGCG (epigallocatechin gallate) has a positive lowering effect on levels of cholesterol, lipids and glucose in the body. The study showed that EGCG reduced the skins fat deposits, as well as the fat stores within the abdomen. On the other hand, the research conducted by the American Journal of Clinical Nutrition showed that green tea has an effect on the bodys metabolism through its promotion of thermogenesis, or calorie burning, in the body. This, coupled with fat oxidation, makes green tea a preferred natural agent for weight loss ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Principal Investigator:HIROHATA Tomio, Project Period (FY):1993 - 1994, Research Category:Grant-in-Aid for General Scientific Research (B), Research Field:Hygiene
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Methods 32 Balb/c female mice were randomly selected into four groups.For 21 days: (1) Control group (n: 8) was given 100 μ L subcutan (sc) saline (SF) once a day, 100 μL intraperitoneal (ip) SF twice a week, (2) BLM group (n: 8) was given 100 μL (100 ug) sc BLM once a day, 100 μL ip SF twice a week, (3) BLM + EGCG group (n:8) was given 100 μL (100 ug) sc BLM once a day, 100 μL (100 μg) ip EGCG twice a week, (4) EGCG group (n: 8) was given 100 μL sc SF once a day, 100 mL (100 μg) ip ECCG twice a week. Hematoxylin&eosin and Masson trichrome staining of dermal areas were performed. Myofibroblast activity was measured using alpha smooth muscle actin antibody (αSMA) by immunohistochemistry.Expression levels of MMP-1, MMP-8, MMP-13 and p-SMAD protein were examined by western blot. Expression levels of TGF-β mRNA were examined by qPCR. All of the statistical analyses were performed using SPSS software and the quantitative data were expressed as the means±SEM.The quantitative variables were ...
The findings were presented June 7 during the annual meeting of the American Society of Clinical Oncology (ASCO). They are the latest in a series of Mayo studies to show promise for use of the chemical epigallocatechin gallate (EGCG) - the major component of green tea - in reducing the number of leukemia cells in patients with CLL. Mayo first tested EGCG in a variety of laboratory assays about eight years ago, and it was found to reduce the survival of CLL leukemic cells. This laboratory finding was followed by a successful phase I clinical trial - the first time green tea extract had been studied in CLL patients.. "Although only a comparative phase III trial can determine whether EGCG can delay progression of CLL, the benefits we have seen in most CLL patients who use the chemical suggest that it has modest clinical activity and may be useful for stabilizing this form of leukemia, potentially slowing it down," says Tait Shanafelt, M.D., a Mayo Clinic hematologist and lead author of the ...
FERNANDEZ, Julieta et al. Three cases of liver toxicity with a dietary supplement intendedto stop hair loss. Rev. esp. enferm. dig. [online]. 2014, vol.106, n.8, pp.552-555. ISSN 1130-0108.. Liver toxicity associated with herbal remedies and dietary supplements is an increasing concern. Several toxic hepatitis cases have been reported in the literature in association with products intended for weight loss where green tea extracts are an ingredient. Three hepatotoxicity cases are reported below in association with the use of Inneov masa capilar®, a dietary supplement intended to stop hair loss whose primary component is green tea catechins. In all of them, other potential causes of acute hepatitis were ruled out. We highlight the importance of awareness regarding these substances at history taking in order to identify and report hepatic adverse reactions secondary to apparently safe herbs as described in the present manuscript.. Palabras clave : Hepatotoxicity; Green tea; Acute hepatitis; ...
Quercetin is the most well researched of all bioflavonoids. It is not actually that good of a supplement on its own, but is an interesting research topic. Tons of interactions, and synergistic with other bioflavonoids and increases absorption of Resveratrol and Green Tea Catechins.
Methods: Animals (male Wistar rats) divided into four groups: sham operated (SH), EGCG-pretreated sham operated (SH + EGCG), untreated lesion (L), and EGCG-pretreated lesion (L + EGCG). Animals in L, L + EGCG, and SH + EGCG groups received sterile saline or saline plus EGCG (10 mg/kg) intraperitoneally one day pre-surgery and every other day for three weeks. The lesion was induced one day after EGCG treatment by injection of water or water containing 2 nmol/µl of β-amyloid (1-40) into the hippocampal fissure. We evaluat ed the morphological changes of hippocampus specially CA3 region by nissl staining after three weeks of surgery ...
Abstract of Paper: Epigallocatechin-3-gallate protects heart and kidney DNA from intestinal ischemia /reperfusion injury in rats , Author: Mohie A. Sheriefl, Haitian A. Soliman2, Azza S. Awed , Year: 2014 , Faculty of Medicine, Benha University
A study has uncovered evidence showing that antioxidant polyphenols called catechins may prevent the formation of sticky plaques that trigger Alzheimers.
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In the central nervous system, nitric oxide (NO) is associated with many pathological diseases such as brain ischemia, neurodegeneration and inflammation. The epigallocatechin gallate (EGCG), a major compound of green tea, is recognized as protective substance against neuronal diseases. This study is aimed to investigate the effect of EGCG on NO-induced cell death in PC12 cells. Administration of sodium nitroprusside (SNP), a NO donor, decreased cell viability in a dose- and time-dependent manner and induced genomic DNA fragmentation with cell shrinkage and chromatin condensation. EGCG diminished the decrement of cell viability and the formation of apoptotic morphologenic changes as well as DNA fragmentation by SNP. EGCG played as an antioxidant that attenuated the production of reactive oxygen species (ROS) by SNP. The cells treated with SNP showed downregulation of Bcl-2, but upregulation of Bax. EGCG ameliorated the altered expression of Bcl-2 and Bax by SNP. The release of cytochrome c from ...
Green Tea offers a world of health benefits, mostly because of the potency of a peculiar nutrient known as a catechin, a healing green superfood
China Plant extract catalog of GMP Certified Plant Extract, GMP Certified Epigallocatechin Gallate Powder Catechin EGCG Green Tea Extract provided by China manufacturer - AnHui Chempro Biochemical Limited, page1.
We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction. HepG2 cells, stably integrated with regulatory regions of human CYP1A1, were treated with resveratrol, apigenin, curcumin, kaempferol, green tea extract (GTE), (−)-epigallocatechin gallate (EGCG), quercetin, and naringenin. Of these flavonoids, resveratrol produced the greatest increase in CYP1A1-mediated luciferase activity (10-fold), whereas GTE, apigenin, curcumin, and kaempferol produced 2- to 3-fold increases in activity. Compared with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), omeprazole, or benzanthracene, where increases in luciferase activity ranged from 12- to 35-fold, these flavonoids exhibited weak agonist activity. The remaining compounds, EGCG, quercetin, and naringenin, produced negligible effects. Cotreatment of cells with TCDD and GTE, naringenin, and apigenin resulted ...
Shu Umera anti oxidant Oil Cleanser The most moisturising and brightening cleanser I have tried. contains catechin, derived from green tea, botanical oils, depsea water, and a calming aroma based on watermelon, jasmine and sandalwood. the formula has anti-oxidant properties, and helps to hydrate and soothe skin. it also naturally provides moisture to skin, and helps to enhance skin transparency and improve skin quality
It really is five:30. I discovered property from operate additionally i have only 15 minutes before Ive to arrange meal and offer with my other each day home chores. Just how can I select to invest all those important fifteen instants? It is really tea time!. The not so terrific? Scientists are concerned concerning the safety of getting eco-friendly tea extract supplements for reduction supplement because of the extremely most substantial doses of environmentally friendly tea nutritional supplement polyphenols requires to operate effectively. The polyphenol that seems for you personally to become best for reinforcing excess fat decline is EGCG, and specially merged with caffeine, it seems to be to get a highly effective excess fat burners.. In excess of modern yrs, analyses have proved that source of wholesome a robust antioxidant that is certainly great for all round system. Inexperienced tea incorporates a little something identified as epigallocatechin gallate or EGCG. This anti-oxidant ...
Phase IB randomized, double-blinded, placebo-controlled, dose escalation study of polyphenon E in women with hormone receptor-negative breast cancer Academic Article ...
epigallocatechin (EGC) are the major polyphenolic constituents in green tea. Inthis study, we characterized the enzymology of cytosolic catechol-O-methyltransferase(COMT)-catalyzed methylation of EGCG and EGC in humans, mice,and rats. At 1 µM, EGCG was readily methylated by liver cytosolicCOMT to 4-O-methyl-EGCG and then to 4,4-di-O-methyl-EGCG; EGCwas methylated to 4-O-methyl-EGC. The Km and Vmax values forEGC methylation were higher than EGCG; for example, with humanliver cytosol, the Km were 4.0 versus 0.16 µM and Vmax were 1.28 versus 0.16 nmol/mg/min. Rat liver cytosol had higher COMT activitythan that of humans or mice. The small intestine had lower specificactivity than the liver in the methylation of EGCG and EGC. Glucuronidationon the B-ring or the D-ring of EGCG greatly inhibited the methylationon the same ring, but glucuronidation on the A-ring of EGCG orEGC did not affect their methylation. Using EGC and 3,4-dihydroxy-L-phenylalanineas substrates, EGCG, 4-O-methyl-EGCG, and ...
Involved in the formula are high doses of, minerals, vitamins and amino acids. The amino acids are the most beneficial substances within this mix.. All of these components are harmless and do not cause any side effects so long as you are not taking this product if you are already taking any other type of brain medication.. Within each pill you will find a unique combination of Vitamin B6, Vitamin C and Vitamin B12, L-methionine, N-acetyl tyrosine and L-histidine, Zinc, Rhodioa rosea, Epigallocatechin gallate and Magnesium - and each of these have been individually tested to have improvements upon brain activity.. The amino acid L-methionine is responsible for the support of methylation pathways and also works together with L-tyrosine and L-histidine and Zinc to support the function of the adrenal gland.. Vitamin B is essential for testosterone production and muscle recovery. It also works with Vitamin C to boost the immune system and together they act as a strong antioxidant for the adrenal ...
As a major nutraceutical component of green tea (−)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists due to its well-documented antioxidant and antiobesity bioactivities. In the current study, we aimed to investigate the protective effect of EGCG on metabolic misalignment and in balancing th
1.Quick Details: Product Name: L-Epicatechin Synonym: 2-(3, 4-dihydroxyphenyl)-2, 3, 4-trihydro-3, 5, 7-trihydroxychromene; EPICATECHIN; CAS No.: 490-46-0 EINECS No.: 207-710-1 Molecular formula: C15H14O6 Molecular weight: 290.27 Packing: 25KG/Drum...
Cytokine SuppressTM with EGCG (epigallocatechin-3-gallate) helps balance inflammatory reactions in the body (works as an anti-inflammatory_, so that they remain
A delicate and slightly bitter flavour delivers all the health benefits of catechins in a foil fresh pack of double chamber tea bags ...
Pounds control program involve catalyst coupled with thinking or in any manner people young and old discontinue prior many start to see the end results. Basically, it isnt the action of snacking that could produce in line with difficulties as things are the species of healthy you ought to feed on that may well give an excellent excess having to do with excess fat and therefore oils. He or she asserted she needed to miss a couple pounds plus vital help you to keep with a diet plan which had been written for my child courtesy of a skilled dietician. Its also critical you and your family acquire some straightforward website marketing learning before youll handle women and men with regards to online business truth about abs. Their tea Through incorporates catechins, this is potent herbal antioxidants known to increase metabolic process and have proven to be pure entire body detoxifiers. The obvious be a success located in getting to your unwanted weight decrease end goal requires you to continue ...
TY - JOUR. T1 - Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2. AU - Isozaki, T.. AU - Tamura, H. O.. PY - 2001/10/4. Y1 - 2001/10/4. N2 - We have previously reported that epigallocatechin gallate (EGCG) strongly inhibits the in vitro phenol sulfo-transferase (P-ST) activity of a human colon carcinoma cell line, Caco-2. In the present study, we examined the ability of EGCG to inhibit the sulfation of 1-naphthol in intact Caco-2 cells. Sulfation of 1-naphthol was detected in Caco-2 cells after 2 h of incubation, and was observed to continue for 24 h, resulting in an accumulation of sulfated 1-naphthol. Sulfation was strongly inhibited by the addition of EGCG to the culture medium. The IC50 of EGCG was calculated to be 20 μM; this value is similar to that obtained from in vitro assays (14 μM) [Ref. Tamura et al., Biol. Pharm. Bull., 23, 695, (2000)]. These results indicate that catechins are capable of inhibiting P-ST activity in ...
Type II phosphatidylinositol (PtdIns) 4-kinases produce PtdIns 4-phosphate, an early key signaling molecule in phosphatidylinositol cycle, which is indispensable for T cell activation. Type II PtdIns 4-kinase alpha and beta have similar biochemical properties. To distinguish these isoforms Epigallocatechin gallate (EGCG) has been evaluated as a specific inhibitor. EGCG is the major active catechin in green tea having anti-inflammatory, antiatherogenic and cancer chemopreventive properties. The precise mechanism of actions and molecular targets of EGCG in early signaling cascades are not well understood. In the present study, we have shown that EGCG inhibits type II PtdIns 4-kinases (alpha and beta isoforms) and PtdIns 3-kinase activity in vitro. EGCG directly bind to both alpha and beta isoforms of type II PtdIns 4-kinases with a Kd of 2.62 mu M and 1.02 mu M, respectively. Type II PtdIns 4-kinase-EGCG complex have different binding pattern at its excited state. Both isoforms showed significant ...
Green tea is a popular healthful beverage in many parts of the world and its medical properties have been extensively explored. Green tea originated in China and the chemistry of green tea is renowned by its presence of polyphenolic compounds, particularly catechins. This book reviews the antioxidant activities of green tea catechins, its consumption and the ways it prevents potential infections; the potential beneficial effects of green tea consumption on Diabetes mellitus and how it can be used to reduce severe brain damage as well as its use in treating obesity. Other chapters examine how catechins may assist in the suppression of heart transplant rejection; a discussion on EGCG as the most abundant catechin green tea and its capability of inhibiting cell proliferation and inducing apoptosis in cancer cells; an evaluation and comparison of the phenolic composition and metal content of commercially available aromatized green tea infusions; and an investigation of the chromatographic behavior ...
The ATP-binding cassette transporters P-glycoprotein (ABCB1 MDR1) and multidrug resistance protein 4 (MRP4) efflux irinotecan and its active metabolite SN-38 genotype was a significant covariate for the clearance of both irinotecan Epigallocatechin gallate lactone and SN-38 Epigallocatechin gallate lactone. of the topoisomerase Epigallocatechin gallate I enzyme [2]. SN-38 undergoes glucuronic acid Rabbit polyclonal to TranscriptionfactorSp1. conjugation to form SN-38 glucuronide by uridine diphosphate glucuronosyltransferase. A diagram of Epigallocatechin gallate irinotecan metabolic pathways has been recently published {Innocenti 2009.. ...
Studies using animal models show that green tea catechins provide some protection against degenerative diseases. Some studies indicated that green tea has an antiproliferative activity on hepatoma cells and a hypolipidemic activity in hepatoma-treated rats, as well as the prevention of hepatoxicity and as a preventive agent against mammary cancer post-initiation. Green tea catechins could also act as antitumorigenic agents and as immune modulators in immunodysfunction caused by transplanted tumors or by carcinogen treatment. Moreover, green tea, its extract, and its isolated constituents were also found to be effective in preventing oxidative stress and neurological problems.. Green tea consumption has also been linked to the prevention of many types of cancer, including lung, colon, esophagus, mouth, stomach, small intestine, kidney, pancreas, and mammary glands. Several epidemiological studies and clinical trials showed that green tea (and black and Oolong teas to a lesser extent) may reduce ...
Low prices on Green Tea (EGCG)! Green tea boosts metabolism and increases fat burning*. Green tea has become a very popular ingredient in weight loss formulas. A green tea catechin called epigallocatechin gallate (EGCG), when combined with caffeine, was shown to boost metabolism beyond that of caffeine alone. EGCG is also a powerful antioxidant that may induce abnormal cells to die (apoptosis) before they wreak their havoc.* One study showed that using a combination of caffeine and EGCG resulted in an average weight loss of 7.7
Low prices on Green Tea! Green tea boosts metabolism and increases fat burning*. Green tea has become a very popular ingredient in weight loss formulas. A green tea catechin called epigallocatechin gallate (EGCG), when combined with caffeine, was shown to boost metabolism beyond that of caffeine alone. EGCG is also a powerful antioxidant that may induce abnormal cells to die (apoptosis) before they wreak their havoc.* One study showed that using a combination of caffeine and EGCG resulted in an average weight loss of 7.7
Our objective was to develop a robust system for anthocyanin-based color intensification, with high-encapsulation capacity and improved stability of the encapsulated natural colorant. Catechin was used to modulate the copigmentation and encapsulation of anthocyanins in counter-ionic polyelectrolyte complexes (PECs) composed of chondroitin sulfate and chitosan. Results showed that catechin copigmentation significantly intensified red color of formulations both with and without encapsulation in PECs and improved the anthocyanin encapsulation efficiency by forming additional dense network through hydrogen bonding. A series of stability assays revealed that anthocyanin stabilizing effect of system depended on the formulated pH and adding order of catechin. The strongest retaining capacity of anthocyanin was observed when catechin was copigmented with anthocyanin directly in PECs at pH 3.3, while the coated layer of catechin covered on PECs would be more effective at pH 4.0 and 5.0. Furthermore, we
The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted.
The green tea (Camellia sinensis) catechin, (-)-epigallocatechin-3-gallate (EGCG), has shown cancer-preventive activity in animal models. Previously, we have reported the bioavailability of EGCG in rats and mice. Here, we report that cotreatment of HT-29 human colon cancer cells with genistein (from soy) increased cytosolic EGCG by 2- to 5-fold compared with treatment with EGCG only. Inclusion of genistein, at non-cytotoxic concentrations, increased the growth inhibitory effects of EGCG against HT-29 cells (up to 2-fold at 20 μM genistein). Intragastric coadministration of EGCG (75 mg/kg) and genistein (200 mg/kg) to CF-1 mice resulted in an increase in plasma half-life (t1/2 148.7 ± 16.4 versus 111.5 ± 23.4 min) and exposure (AUC0→∞ 183.9 ± 20.2 versus 125.8 ± 26.4 μg/ml × min) of EGCG. Cotreatment with genistein also increased the maximal concentration (Cmax), 6 h exposure (AUC0→360 min), and t1/2 of EGCG in the small intestine by 2.0-, 4.7- and 1.4-fold, respectively, compared ...
Lattice Corneal Dystrophy is associated with painful recurrent corneal erosions and amyloid corneal opacities induced by transforming growth factor β induced protein (TGFBIp) that impairs vision. The exact mechanism of amyloid fibril formation in Corneal Dystrophy is unknown but has been associated with destabilizing mutations in the fourth fasciclin 1 (Fas1-4) domain of TGFBIp. The green tea compound Epigallo-catechin gallate (EGCG) has been found to inhibit fibril formation of various amyloidogenic proteins in vitro. In this study we investigated the effect of EGCG as a potential treatment in Lattice Corneal Dystrophy (LCD) using Fas1-4 with the naturally occurring LCD-inducing A546T mutation. A few molar excess of EGCG were found to inhibit fibril formation in vitro by directing Fas1-4 A546T into stable EGCG-bound protein oligomers. Incubation with two molar equivalent EGCG led to a 4-fold reduction in the aggregates membrane disruptive potential, potentially indicative of significantly ...
Nabeeh A. AlQahtani, Immediate Implant Placement with Immediate Loading in Periodontally Compromised Patients: A Literature Review. Journal of International Oral Health 2016; 8(5): 1-7. Yuvaraja M, Reddy NR, Kumar PM, Ravi KS, Nabeeh A. AlQahtani. Thermoreversible gel for intrapocket delivery of green tea catechin as a local drug delivery system: An original research. J Adv Pharm Technol Res 2016; 7:139-43.
Green tea as most as people know, it comes from leaves of tea plants. Nowadays people like to drink it very much. In my opinion, you should know about the benefits of green tea for three reasons. First , drinking green tea can repress cholesterol which leads to high blood pressure. Green tea polyphenols are effective in lowering blood sugar. Moreover, catechins are effective for preventing cancer and it can help prevent the decay of your tooth. Second, green tea can make your weight loss. If you drink green tea, you can lower cholesterol because it increases the bodys rate of burning calories. Drinking green tea regularly will increase your metabolism and help burn energy safely and naturally. It prevents obesity. Finally, high grade green tea from 100% quality tea leaves is the most beneficial. In conclusion, green tea is good for health because it contains good nutrients. Have you got any ideas about green tea? ...
The powers of green tea are attributed to antioxidant compounds called catechins, which has been shown to destroy certain viruses and bacteria, boost immunity and fight prostate cancer. Research has shown that green tea polyphenols can significantly lower the levels of biomarkers for prostate cancer. Green tea catechins also may help men who have pre cancerous prostate lesions, which alert a high risk of developing prostate cancer. Studies show that men who drink at least 3 cups of green tea a day have a reduced risk of prostate cancer. Experts have found that compounds of green tea interfere with the activity of an enzyme having a role in initiating prostate cancer. These compounds also prompt prostate cancer cells to destroy. Catechins help to repair damaged DNA that can otherwise trigger cancer growth. ...
The powers of green tea are attributed to antioxidant compounds called catechins, which has been shown to destroy certain viruses and bacteria, boost immunity and fight prostate cancer. Research has shown that green tea polyphenols can significantly lower the levels of biomarkers for prostate cancer. Green tea catechins also may help men who have pre cancerous prostate lesions, which alert a high risk of developing prostate cancer. Studies show that men who drink at least 3 cups of green tea a day have a reduced risk of prostate cancer. Experts have found that compounds of green tea interfere with the activity of an enzyme having a role in initiating prostate cancer. These compounds also prompt prostate cancer cells to destroy. Catechins help to repair damaged DNA that can otherwise trigger cancer growth. ...
Catechin is an active ingredient of green tea. It is reported to inhibit corticosteroid‑induced anxiety and depression‑like symptoms. Considering the complex nature of depression, effects of catechin need to be studied in a clinically relevant depression model. The present study was designed to explore the antidepressant effect of catechin in Sprague Dawley rats subjected to chronic unpredictable mild stress (CUMS). Animals were subjected to CUMS and treated with (+)‑catechin (50 mg/kg) or escitalopram (10 mg/kg) orally; a CUMS control and a vehicle control that was not exposed to CUMS were also established. Various stressors were applied daily in an unpredictable manner for 8 weeks achieve CUMS. Sucrose preference test were performed after 4 and 8 weeks and forced swim tests (FSTs) were conducted at weeks 4, 6 and 8. At the end of week 8, animals were sacrificed and the brain homogenate was studied for antioxidant parameters. Compared with the vehicle control, animals of the CUMS control ...
China Polyphenols 95%, Catechins 70%, EGCG 30% Green Tea Extract, Find details about China Green Tea Extract, Herbal Extract from Polyphenols 95%, Catechins 70%, EGCG 30% Green Tea Extract - Kingherbs Limited
Concentrated Green Tea Extract Shields cells against free-radical damage Why is green tea so highly regarded? It is a powerful free-radical fighter. Green tea contains polyphenols - antioxidant components that can protect cells from free-radical damage. In fact, the National Institutes of Health have studied green teas many advantages. Why take Green Tea Elite with EGCG? It provides the benefits of green tea, intensified. This standardized supplement contains 60% polyphenols, compared to 8% to 12% in dried green tea leaf. Its also standardized for a minimum of 40% epigallocatechin-3-0-gallate, one of the most beneficial, power hitters of the polyphenols. Plus, unlike green tea drinks, this supplement is caffeine-free. Ultra absorbable. Green Tea Elite with EGCG combines one part standardized, caffeine-free green tea extract with two parts phosphatidylcholine, creating a green tea supplement with exceptional absorption and delivery to the cells in your body.
TY - JOUR. T1 - Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. AU - Li, Changhong. AU - Allen, Aron. AU - Kwagh, Jae. AU - Doliba, Nicolai M.. AU - Qin, Wei. AU - Najafi, Habiba. AU - Collins, Heather W.. AU - Matschinsky, Franz M.. AU - Stanley, Charles A.. AU - Smith, Thomas J.. PY - 2006/4/14. Y1 - 2006/4/14. N2 - Insulin secretion by pancreatic β-cells is stimulated by glucose, amino acids, and other metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in this process. The importance of GDH was underscored by features of hyperinsulinemia/hyperammonemia syndrome, where a dominant mutation causes the loss of inhibition by GTP and ATP. Here we report the effects of green tea polyphenols on GDH and insulin secretion. Of the four compounds tested, epigallocatechin gallate (EGCG) and epicatechin gallate were found to inhibit GDH with nanomolar ED50 values and were therefore found to be as potent as the physiologically ...
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WHAT IS MATCHA? Doctor King Finest Ceremonial Grade Organic Japanese Matcha is an exquisite, finely milled green tea made from the finest, young, shade-grown leaves, which were selected during the first harvest from Camellia Sinensis plants grown in beautiful organic tea gardens in Japan. During cultivation, special covers were applied over the plants for more than twenty days to produce shade. Shade induces production of chlorophyll, L-theanine and other valuable nutrients in the leaves. Unlike other green teas (where after steeping the tea, the leaves are removed), the leaves are consumed in matcha green tea, with all their valuable nutrients. WHAT ARE THE HEALTH BENEFITS OF ORGANIC JAPANESE MATCHA? The health benefits include: [1] Matcha tea is a SUPER due to the high density of antioxidants. Research at the University of Colorado Colorado Springs, USA, indicates that Ceremonial Grade Japanese Matcha contains 137 times the epigallocatechin gallate (EGCG) antioxidants of standard green tea, ...
Introduction: Cerebral ischemia/reperfusion injury following cardiac arrest and cardiopulmonary resuscitation (CPR) has been demonstrated. Oxidant injury plays a critical role in the process. Since tea polyphenols from green tea are efficient free radical and singlet oxygen scavengers. We therefore sought to investigate if tea polyphenols would be effective in a rat model of asphyxial cardiac arrest.. Hypothesis: We hypothesized that tea polyphenols could reduce cerebral ischemia/reperfusion injury and consequently improve the outcome of CPR via counteracted the oxidant injury.. Methods: Male Sprague-Dawley rats, weighing 200-400 g, were induced cardiac arrest by clamping the trachyeal tubes. Cardiac arrest was determined by loss of aortic pulsations and mean aortic pressure , 10mmHg. At the end of 8 min of clamping, mechanical chest compression at a rate of 180/min was performed. Ventilation was started with room air at 70 breaths per min and tidal volume adjusted to 6 ml/kg. Epinephrine was ...
TY - JOUR. T1 - Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity. AU - Bae, Jaehoon. AU - Kumazoe, Motofumi. AU - Fujimura, Yoshinori. AU - Tachibana, Hirofumi. PY - 2019/2/1. Y1 - 2019/2/1. N2 - Obesity is a major problem in developed countries and a burden on social health care systems. Several epidemiological studies showed the protective effects of green tea against obesity-related diseases. Cyclic guanosine monophosphate (cGMP) acts as a mediator for the physiological effects of (−)-epigallocatechin-3-O-gallate, the major constituent of green tea. Here, we showed that the level of phosphodiesterase 5, a negative regulator of cGMP, was up-regulated in adipose tissues of high-fat/high-sucrose (HF/HS) diet-fed mice and that this up-regulation was ameliorated by diallyl disulfide (DADS), the major organosulfur in garlic. A green tea extract (GT) and DADS in combination attenuated HF/HS diet-induced adipose increase and triglyceride ...
A type proanthocyanidins are a specific type of proanthocyanidins, which are a class of flavanoid. Proanthocyanidins fall under a wide range of names in the nutritional and scientific vernacular, including oligomeric proanthocyanidins, flavanoids, polyphenols, condensed tannins, and OPCs. Proanthocyanidins were first popularized by French scientist Jacques Masquelier. A-type linkage is a less common feature in proanthocyanidins with both 4β→8 (B-type) and 2β→O→7 interflavanoid bonds. A-type proanthocyanidin glycosides can be isolated from cocoa liquor. Procyanidin A1 is an epicatechin-(2β→7,4β→8)-epicatechin dimer. Procyanidin A2 is a dimeric (-)epicatechin. Other A-type proanthocyanidins can be found in cranberries, cinnamon, peanut skins and Geranium niveum. B-type procyanidins (catechin dimers) can be converted to A-type procyanidins by radical oxidation. Fragmentation patterns for A-type proanthocyanidins include heterocyclic ring fission (HRF), retro-Diels-Alder (RDA) fission, ...
Abstract: ABSTRACT Although many mouse models of lung adenocarcinoma exist, there is no mouse lung squamous cell carcinoma model that has been validated for use in preclinical lung cancer chemoprevention studies. Since most clinical chemoprevention trials of lung cancer are performed in subjects with bronchial dysplasia, development of a lung squamous cell carcinoma mouse model becomes one of the highest priorities. We have shown that lung squamous cell carcinomas can be induced chemically in several strains of mice (Wang et al. 2004) and that green tea polyphenols exhibit a significant efficacy against the development of lung squamous cell carcinomas (preliminary data section). In this proposal, we will use a standardized green tea preparation called Polyphenon E (PE) and its major component, EGCG. The overall objective of this proposal is to determine the efficacy of green tea polyphenols in a mouse lung squamous cell carcinoma model and to determine the molecular mechanism that underlies the ...
... was invented by Schlesinger Walter in the U.S. It was marketed as an anti-anxiety agent in 1981. However, Halazepam is not commercially available in the United States because it was withdrawn by its manufacturer for poor sales.[1] ...
... and catechins (in green tea). ...
പെർഫൊറേറ്റ് സെൻറ് ജോൺസ് വോർട്ട്,[1] കോമൺ സെൻറ് ജോൺസ് വോർട്ട്, സെൻറ് ജോൺസ് വോർട്ട് എന്നീ നാമങ്ങളിലറിയപ്പെടുന്ന ഹൈപെരികം പെർഫൊറാറ്റം ഹൈപെരികേസീ കുടുംബത്തിലെ സപുഷ്പി സസ്യമാണ്. ആന്റീഡിപ്രസന്റ് പ്രവർത്തനമുണ്ടെങ്കിലും ഒരു ഔഷധ സസ്യം ആയി ഉപയോഗിക്കുവാൻ വേണ്ടുന്ന ഉയർന്ന ഗുണമേന്മയുള്ള ക്ലിനിക്കൽ തെളിവുകൾ പരിമിതമാണ്. കന്നുകാലികളെ സംബന്ധിച്ചിടത്തോളം ഈ സസ്യം വിഷമയമാണ്. [2] ...
Catechin, tannin , ALIGN=LEFT VALIGN=TOP , लघु, रूक्ष , ALIGN=LEFT VALIGN=TOP , तिक्त, कषाय , ALIGN=LEFT VALIGN=TOP , कटु , ...
7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, ...
... and catechins have also been found to increase adiponectin expression.[34] ...
NaBr crystallizes in the same cubic motif as NaCl, NaF and NaI. The anhydrous salt crystallizes above 50.7 °C.[7] Dihydrate salts (NaBr·2H2O) crystallize out of water solution below 50.7 °C.[8] NaBr is produced by treating sodium hydroxide with hydrogen bromide. Sodium bromide can be used as a source of the chemical element bromine. This can be accomplished by treating an aqueous solution of NaBr with chlorine gas: ...
Pianese, C. P.; Hidalgo, L. O.; Gonz??Lez, R. H.; Madrid, C. E.; Ponce, J. E.; Ram??Rez, A. M.; Mor??n, L. M.; Arenas, J. E.; Rubio, A. T.; Uribe, J. O.; Abiuso, J. ?; Hanuch, E.; Alegr??a, J.; Volpi, C.; Flaskamp, R.; Sanju??n, A. P. ?A.; g??Mez, J. M. G. ?A.; Hern??Ndez, J.; Pedraza, A.; Quijano, D.; Mart??Nez, C.; Casta??Eda, J. R. ?N.; Guerra, O. J. C. ?O.; f, G. V. (২০০২)। "New approaches to the management of peripheral vertigo: Efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study"। Otology & neurotology : official publication of the American Otological Society, American Neurotology Society \and] European Academy of Otology and Neurotology। 23 (3): 357-363। doi:10.1097/00129492-200205000-00023। PMID 11981396 ...
According to legends, the history of theriac begins with the king Mithridates VI of Pontus who experimented with poisons and antidotes on his prisoners. His numerous toxicity experiments eventually led him to declare that he had discovered an antidote for every venomous reptile and poisonous substance. He mixed all the effective antidotes into a single one, mithridatium or mithridate. Mithridate contained opium, myrrh, saffron, ginger, cinnamon and castor, along with some forty other ingredients.[12] When the Romans defeated him, his medical notes fell into their hands and Roman medici began to use them. Emperor Nero's physician Andromachus improved upon mithridatum by bringing the total number of ingredients to sixty four, including viper's flesh,[12] a mashed decoction of which, first roasted then well aged, proved the most constant ingredient.[13] Lise Manniche, however, links the origins of theriac to the ancient Egyptian kyphi recipe, which was also used medicinally.[14] Greek physician ...
... is generally considered a non-polar solvent. Owing to the good polarizability of the chlorine atoms, it is a superior solvent for organic compounds that do not dissolve well in hydrocarbons such as hexane. It is an excellent solvent for many organic materials and also one of the least toxic of the chlorinated hydrocarbons. Prior to the Montreal Protocol, it was widely used for cleaning metal parts and circuit boards, as a photoresist solvent in the electronics industry, as an aerosol propellant, as a cutting fluid additive, and as a solvent for inks, paints, adhesives, and other coatings. 1,1,1-Trichloroethane is also used as an insecticidal fumigant. It was also the standard cleaner for photographic film (movie/slide/negatives, etc.). Other commonly available solvents damage emulsion, and thus are not suitable for this application. The standard replacement, Forane 141 is much less effective, and tends to leave a residue. 1,1,1-Trichloroethane was used as a thinner in ...
The aquatic plant Myriophyllum spicatum produces ellagic, gallic and pyrogallic acids and (+)-catechin.[60] ... For example, ellagic acid is a dimer of gallic acid and forms the class of ellagitannins, or a catechin and a gallocatechin can ... An example of such molecules is catechin. Cavicularin is an unusual macrocycle because it was the first compound isolated from ... catechin, allelopathic phenolic compounds inhibiting the growth of blue-green alga Microcystis aeruginosa.[60] ...
Anthocyanins tend to be the main polyphenolics in purple grapes, whereas flavan-3-ols (i.e. catechins) are the more abundant ...
7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, ...
Delini-Stula, A.; Fischbach, R.; Gnirss, F.; Bures, E.; Pöldinger, W. (1985). "Early experience with CGP 4718 A (Sercloremine), a new selective and reversible MAO-A and 5-HT-uptake inhibitor, in the treatment of depressive patients". Drug Development Research. 6 (4): 371-384. doi:10.1002/ddr.430060409. ISSN 0272-4391 ...
... , a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels.[3] ...
... catechin dimer) to A-type: evidence for abstraction of C-2 hydrogen in catechin during radical oxidation". Tetrahedron Letters ... Dimeric catechin. Procyanidin A2. Procyanidol A2. Proanthocyanidin A-2. Procyanidin dimer A2. (+)-Proanthocyanidin A2. ... Trimers: Arecatannin B1 (epicatechin-(4β→8)-epicatechin-(4β→6)-catechin) ...
It is believed that honokiol acts on GABAA receptors similarly to benzodiazepines and Z-drugs. However, honokiol has been shown to achieve anxiolysis with fewer motor or cognitive side effects than GABAA receptor agonists such as flurazepam and diazepam. It has been shown that honokiol likely has a higher selectivity for different GABAA receptor subtypes and both magnolol and honokiol showed higher efficacy when acting on receptors containing δ subunits.[1] GABAA receptors control ligand-gated Cl− channels that can help increase seizure thresholds through the influx of chloride anions. Honokiol may also affect the synthesis of GABA. In a study where mice received seven daily injections of honokiol, researchers observed a significant increase in hippocampal levels of glutamate decarboxylase (GAD)(67) a precursor to GABA.[24] ...
... including catechin, epicatechin, p-coumaric acid, caffeic acid, and ferulic acid.[30][31] ...
7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, ...
... is an alkaloid found in Corydalis (Papaveraceae) and Dicentra, plants in the family Fumariaceae that can cause fatal poisoning in sheep and cattle.[citation needed] It has been shown to act as an acetylcholinesterase inhibitor,[1] and inhibits biosynthesis of dopamine via inhibition of the enzyme tyrosine hydroxylase.[2][3] Like apomorphine, it is reported to be an inhibitor of amyloid beta protein (Aβ) fiber formation, whose presence is a hallmark of Alzheimer's disease (AD). Bulbocapnine is thus a potential therapeutic under the amyloid hypothesis.[4] According to the Dorlands Medical Dictionary, it "inhibits the reflex and motor activities of striated muscle. It has been used in the treatment of muscular tremors and vestibular nystagmus".[5] A psychiatrist at Tulane University named Robert Heath carried out experiments on prisoners at the Louisiana State Penitentiary using bulbocapnine to induce stupor.[6] This work at Tulane inspired, and was continued parallel to, experiments ...
... has been used since the 1970s in Australia as an emergency analgesic for short-term use, mostly by the Australian and New Zealand Defence Forces,[13] the Australian ambulance services,[10][35][36] and since 2018 by some Emergency medical services in Germany.[57] All of the currently used volatile anesthetic agents are organofluorine compounds. Aside from the synthesis of Freon (Thomas Midgley, Jr. and Charles F. Kettering, 1928)[58] and the discovery of Teflon (Roy J. Plunkett, 1938),[59] the field of organofluorine chemistry had not attracted a great deal of attention up to 1940 because of the extreme reactivity of elemental fluorine, which had to be produced in situ for use in chemical reactions. The development of organofluorine chemistry was a spin-off from the Manhattan Project, during which elemental fluorine was produced on an industrial scale for the first time. The need for fluorine arose from the need to separate the isotope 235U from 238U because the former, present in ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
... is a competitive antagonist for the GABAB receptor.[1] This drug is an analogue of the GABAB agonist baclofen. The GABAB receptor is heptahelical receptor, expressed as an obligate heterodimer, which couples to the Gi/o class of heterotrimeric G-proteins. The action of saclofen on the central nervous system is understandably modest, because G-proteins rely on an enzyme cascade to alter cell behavior while ionotropic receptors immediately change the ionic permeability of the neuronal plasma membrane, thus changing its firing patterns. These particular receptors, presynaptically inhibit N- and P/Q- voltage-gated calcium channels (VGCCs) via a direct interaction of the dissociated beta gamma subunit of the g-protein with the intracellular loop between the 1st and 2nd domain of the VGCC's alpha-subunit; postsynaptically, these potentiate Kir currents. Both result in inhibitory effects. However, in animal experiments, saclofen is paradoxically observed to have an antiepileptic effect. This ...
On June 30, 2009, a U.S. Food and Drug Administration (FDA) advisory panel voted by a narrow margin to advise the FDA to remove Vicodin and another opioid, Percocet, from the market because of "a high likelihood of overdose from prescription narcotics and acetaminophen products".[23] The panel also cited concerns of liver damage from their acetaminophen component, which is also the main ingredient in commonly used nonprescription drugs such as Tylenol.[23] Each year, acetaminophen overdose is linked to about 400 deaths and 42,000 hospitalizations.[24] In January 2011, the FDA asked manufacturers of prescription combination products that contain acetaminophen to limit the amount of acetaminophen to no more than 325 mg in each tablet or capsule within 3 years.[25][26][27][28] The FDA also required manufacturers on all acetaminophen containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic ...
... is one of the main catechins metabolites found in humans after consumption of green tea infusions.[8] ... Pietta, P. G.; Simonetti, P.; Gardana, C.; Brusamolino, A.; Morazzoni, P.; Bombardelli, E. (1998). "Catechin metabolites after ...
They are oligomeric compounds, formed from catechin and epicatechin molecules. They yield cyanidin when depolymerized under ... Trimers: Arecatannin B1 (epicatechin-(4β→8)-epicatechin-(4β→6)-catechin) ... Reaction on condensed tannins from Douglas fir bark produces epicatechin and catechin thioglycolates.[24] ... resulting in a red color of the test in the presence of catechin or proanthocyanidins. ...
The aim of this study is to discuss the non-catechin flavonoids (NCF)from Camellia sinensis (L.)O. Kuntze seed improving TNF-α ... N2 - The aim of this study is to discuss the non-catechin flavonoids (NCF)from Camellia sinensis (L.)O. Kuntze seed improving ... AB - The aim of this study is to discuss the non-catechin flavonoids (NCF)from Camellia sinensis (L.)O. Kuntze seed improving ... abstract = "The aim of this study is to discuss the non-catechin flavonoids (NCF)from Camellia sinensis (L.)O. Kuntze seed ...
Studies suggest that catechins, the main compounds in green tea, may help fight infection. Green tea consumption has been ... Green tea catechins may help reduce oxidative stress in people who have tuberculosis. More research is needed before a ... To treat diabetes, 456-582.8 milligrams of catechins in the form of green tea or packets of green tea extracts have been taken ... Four cups of green tea separated by 6-8 hours or green tea containing 75-576 milligrams of catechins have been taken by mouth ...
Catechin. Clinical Trials as Topic. Diabetes Mellitus, Type 2. Humans. Insulin Resistance. Liver. Muscle, Skeletal. Nitric ...
... catechin (0.063±0.011 µg/ml) and epicatechin (0.060±0.009 mg/ml). In vitro antioxidant analysis of wine was able to ...
Its main active components are a type of polyphenols known as flavonoids, which include catechins and theaflavins. Several ...
Z 7300 use Catechin Z, Travatan use Travoprost Z-DNA use DNA, Z-Form ...
Muscle Soreness Relief after Exercise at 70% MHR and Antioxidant Effects of Catechin. Kasem Chaiklongkit; Faculty of Sport ...
Pleural effusion is a common clinical problem in everyday clinical practice. Vascular endothelial growth factor (VEGF) is a 34-45 kDa homodimeric glycoprotein, which is a potent mediator of angiogenesis and vascular permeability. VEGF is present in significant quantities in pleural effusions of different origins, and its levels are consistently higher in exudates than in transudates. There is compelling experimental evidence demonstrating that VEGF is a crucial mediator in fluid formation. In the pleural space mesothelial cells are likely the principal source of fluid VEGF. It is also produced by most malignant cell types and inflammatory cells including lymphocytes, eosinophils, macrophages, and neutrophls. VEGF production can be stimulated by various cytokines, among which transforming growth factor beta (TGF-β) appears to be the most potent and consistent. Hypoxia and ischemia are the most established physical stimulators of VEGF. Promising results are rapidly accumulating on the use of VEGF ...
Here we review the in vivo and in vitro evidence for considering grape-derived polyphenolics, the flavonoids- catechins, ...
This tea catechin also makes it easier for the liver to turn body fat into energy. Studies found that people who drank tea and ... The polyphenols and catechins of tea accelerate the metabolic rate and make the body faster and faster. ... EGCG or epigallocatechin gallate, the main catechin is known to increase fat oxidation, helping to remove fat from the body and ... Green tea leaves are also filled with antioxidants called catechins and polyphenols. ...
It contains a variety of stimulants like caffeine and antioxidants like catechins. ...
PDF Similar Articles Mail to Author Mail to Editor Biochemical and Histopathological Effects of Catechin on Experimental ...
... catechin) and the phloroglucin hyperforin. The inhibition of neuronal uptake of serotonin and other biogenic amines and amino ...
Enhancing the bioavailability of green tea catechins with vitamin C and xylitol ...
The high content of different anti-oxidants, called polyphenols, and compounds called catechins that are present in green tea ...
Catechins, epicatechins, epigallocatechins and gallocatechins are flavanols found in superfoods like green tea, chocolate, ...
One particular catechin, EGCG (epigallocatechin gallate), especially helps break down fat, says Pauline Jose, MD, a clinical ... Antioxidants in Sport Nutrition: Chapter 8: Green Tea Catechins and Sport Performance ... other research has observed that green tea catechins must be ingested with caffeine in order to aid in weight loss, according ... A warm cup of green tea may offer some moderate metabolism-boosting benefits due to antioxidants called catechins, says ...
Catechins. Green eta and apple contains catechins. Catechins are said to reduce body fat and cardiovascular risks. ...
of (+)-catechin in model systems. Journal of Agricultural and Food Chemistry, 44, 1712-1715. Piraprez, G, Herent, M.F. and ... reduction in 4-EP levels when 1g/L of either catechin or procyanidins was added to the solution during culturing of ...
7. Song, J.M., K.H. Lee, and B.L. Seong, Antiviral effect of catechins in green tea on influenza virus. Antiviral Res, 2005. 68 ...
"Research has shown that green tea contains compounds called catechins that may aid in weight loss. Specifically, a catechin ...
PYC contains a wide variety of procyanidins that range from the monomeric catechin and taxifolin to oligomers with 7 or more ...
Accordingly, large quantities of tea catechins were used in the current study, and the consumption of such amounts is indeed a ... In this study, markedly larger amounts of tea catechins than humans would normally be consumed in typical foods that were ... T. Murase, A. Nagasawa, J. Suzuki, T. Hase, and I. Tokimitsu, "Beneficial effects of tea catechins on diet-induced obesity: ... Tea leaves contain tea polyphenols such as catechins, so regular consumption of green tea is thought to be beneficial to ones ...
Polyphenols of grape in the food concentrate "Enoant" are represented by anthocyanins, leucoanthocyanins, catechins, tannins in ...
CATECHINS , BRAZIL , PLANT SCIENCES , GALLIC ACID , ANTIBACTERIAL ACTIVITY , INTEGRATIVE & COMPLEMENTARY MEDICINE , ...
  • PYC contains a wide variety of procyanidins that range from the monomeric catechin and taxifolin to oligomers with 7 or more flavonoid subunits. (pianolarge.ml)
  • Its catechin content is also absorbed the body tissues but concentrate in the digestive tract and liver among subject laboratory animals and dogs, showing how protective it could be for these regions. (grit.com)