Med Clin (Barc). 2008 Oct 18;131(13):487-92. English Abstract; Multicenter Study; Research Support, Non-U.S. Govt; Validation Studies

Pain catastrophizing (the cognitive-emotional tendency to ruminate about pain, magnify pain, and feel helplessness in response to pain) enhances pain and pain-related outcomes. However, the mechanisms by which catastrophizing modulates pain are poorly understood. Evidence suggests that catastrophizing modulates supraspinal processing of pain, but does not modulate spinal nociception (as assessed by nociceptive flexion reflex [NFR]). Unfortunately, these studies have all been cross-sectional and relied on between-subject correlations, which limit conclusions about causation. To address this limitation, the present study experimentally reduced catastrophizing to determine whether it modulates spinal nociception (NFR). Healthy pain-free participants (N=113) were randomly assigned to a brief 30-minute catastrophizing reduction manipulation or a control group that received pain education. Before and after manipulations, 2 types of painful stimuli were delivered to elicit (1) NFR (single trains of ...

PHOENIX, March 7, 2014 /PRNewswire-USNewswire/ -- Stanford Researchers Show Conditioned Pain Modulation Equals Less Activity in the Human Spinal Cord.

18.EdwardsRR,FillingimRB: Effectsofageontemporalsummationand habituationofthermalpain:clinicalrelevanceinhealthyolderand youngeradults. JPain 2001, 2 (6):307 317. 19.FillingimRB,MaixnerW,KincaidS,SilvaS: Sexdifferencesintemporal summationbutnotsensory-discriminativeprocessingofthermalpain. Pain 1998, 75 (1):121 127. 20.ValenciaC,KindlerLL,FillingimRB,GeorgeSZ: Investigationofcentralpain processinginshoulderpain:convergingresultsfrom2musculoskeletal painmodels. jpainoffjAmPainSoc 2012, 13 (1):81 89. 21.PriceDD,McHaffieJG: Effectsofheterotopicconditioningstimulionfirst andsecondpain:apsychophysicalevaluationinhumans. Pain 1988, 34 (3):245 252. 22.HerreroJF,LairdJM,Lopez-GarciaJA: Wind-upofspinalcordneurones andpainsensation:muchadoaboutsomething? ProgNeurobiol 2000, 61 (2):169 203. 23.LautenbacherS,KunzM,BurkhardtS: TheeffectsofDNIC-typeinhibition ontemporalsummationcomparedtosinglepulseprocessing:doessex matter? Pain 2008, 140 (3):429 435. 24.FarrellM,GibsonS: ...

Persistent pain can upset your teens ability to concentrate in school, participate in sports and socialize with friends. Were here to help.

The PROMIS Pain Catastrophizing and Pain Related Self-efficacy item banks (funded by PCORI; 12/01/2014-11/30/2016) This project will develop and validate the PROMIS Pain Catastrophizing and Pain Related Self-efficacy item banks. Measuring these pain-related constructs is important for pain research and clinical practice ...

Objective. We sought to gain a better understanding of whether glaucoma patients negative thoughts during Humphrey visual field (HVF) testing were related to HVF variability. Background. HVF tests are often unreliable in glaucoma patients, but continue to play a vital role in glaucoma clinical trials and clinical decision-making. Methods. We adapted the Pain Catastrophizing Scale to assess negative thoughts (e.g., cant stand it; feel its awful; fear of failing or doing poorly; something serious may happen; anxiously want it to end) related to vision loss and HVF test performance. We administered this catastrophizing questionnaire to 52 glaucoma patients within 20 minutes of HVF test completion during a routine clinic visit. HVF variability of the mean deviation score [coefficient of variation (CoV)] was based on the last 3-4 tests obtained in the past 4 years. Results. A quarter of patients (13/52) demonstrated catastrophizing during HVF testing (i.e., their responses mapped well to the questionnaire

The aim of this prospective study was to explore the role of catastrophizing in vulvovaginal pain. The study entails two research questions. The first question was whether catastrophizing predicts the occurrence of vulvovaginal pain. The second question focused on exploring the links between catastrophizing, partner responses and pain. Five hundred and ten women filled out questionnaires at two measurement points, 10months apart. The women were divided into three groups based on levels of catastrophizing. To study the first research question, the groups were used as predictors of pain at follow-up. To study the second research question, the groups were compared regarding their perceived solicitous partner responses. Subsequently, two mediation models were tested to explore whether catastrophizing mediated the relationship between solicitous partner responses and pain, cross-sectionally and longitudinally. Baseline levels of catastrophizing distinguished between pain and no pain 10months later. ...

PMID: 22558610 Aims: To investigate the influence of noxious stimulation of the temporomandibular joint (TMJ) on conditioned pain modulation (CPM) and the possible influence of gender on such CPM effects in the craniofacial region of humans. Methods: Twenty healthy men and 20 healthy women participated in two sessions. Conditioning stimulation (CS) was standardized mechanical stimulation of pericranial muscles at a pain level of 5 on a 0 to 10 visual analog scale (VAS). Intra-articular electrical stimuli were applied to the left TMJ with an intensity around VAS = 5 (painful session). No electrical stimulation was applied in the control session. Pressure pain threshold (PPT) and pressure pain tolerance threshold (PPTol) were used as responses to pressure (test) stimuli and were assessed in the right masseter muscle and left forearm before and during TMJ stimulation in addition to the CS (during, immediately after, and 10 minutes after CS). PPT and PPTol were analyzed by multilevel analysis of ...

Predicting post-surgical outcomes is notoriously tricky. A good surgeon is not just technically gifted, but will always pick winners on which to operate. That said, understanding the causes of poor outcomes is incredibly (and increasingly) important. A study team in Birmingham (USA) set out to solve the thorny question of whether or not the outcomes of shoulder surgery are affected by psychological distress, and if psychological distress in itself is associated with alteration in the perception of symptoms.1 The study team used the Shoulder Pain and Disability Index (SPADI), a validated score administered to 139 patients, all with a primary shoulder diagnosis. In addition, the patients completed a range of psychological tests including catastrophising and depression scales. Of perhaps most interest here is the result of the multivariate analysis which was performed to explain variation in the SPADI score as a primary outcome. Amazingly, the outcomes as measured by the SPADI score were not ...

Fibromyalgia patients with one or more sleep-related problems were found to have higher direct and indirect medical costs than those with no sleep pro

As reported previously, highly ordered collagen cuffs were observed around preterminal nerve fibers in the skin of fibromyalgia patients for unknown r

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344444/# J Pain Res. 2017; 10: 515-525. Published online 2017 Mar 3. doi: 10.2147/JPR.S128508 PMCID:...

Quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. It is a valuable tool to help identify central sensitization and may be important in the treatment of chronic neck pain. This study is a cross-sectional study. Two groups including chronic neck pain group and healthy volunteers group will be arranged in this study. The healthy subjects will be matched for sex and age in relation to the neck pain group. The pressure pain threshold (PPT) will be measured at the neck muscle in both groups. The cold pressor test will be used in both groups to activate conditioned pain modulation ...

I am often asked by my patients why their pain feels so much worse when they are stressed out or feeling in the dumps. Today, I found a review of the best reason Ive ever heard, and the new explaination Ill give to my patients. Believe me, in the field of healthcare there is something new to learn every day. As a take home point from this article, Id say that it is to do whatever you can to increase your positive outlook on the world, especially if you have a new injury or suffer from chronic pain. Your good health depends on it. Heres the entire review from the fantastic group at the Neuro Orthopaedic Institute Australasia (noigroup.com): "The article (Edwards RR et al 2008 Association of catastrophising with interleukin-6 responses to acute pain. Pain 140: 135-144 ) really struck home. In essence, these authors demonstrated a link between catastrophisation and elevated levels of the pro-inflammatory cytokine interleukin-6. Interleukin-6 (IL-6) is one of a number of pro-inflammatory ...

Article from Fibromyalgia News Today (FNT) - Skin of Fibromyalgia Patients Could Provide Disease Clue Id like to share this interesting, but short article that has expanded my opinion about the link between Fibro, inflammatory/autoimmune disorders and Connective Tissue/Collagen Disorders. Via this link: Skin of Fibromyalgia Patients Could Provide Disease Clues Via: Fibromyalgia News Today.…

Growing evidence suggests that psychosocial factors play a role in persistent musculoskeletal pain.1 Poor self-efficacy, coping, somatising, helplessness and pain catastrophising are frequently present in knee pain disorders such as knee osteoarthritis (OA).1 These factors can complicate recovery and limit with the benefits of rehabilitation.2 As such, the presence of psychosocial impairments is important in treatment decision-making for many musculoskeletal conditions.3 Quality of life (QoL) is also impaired in people … ...

July 2013 References for Research Update Devin J. Starlanyl for http://www.sover.net/~devstar. Ablin JN, Buskila D. 2013. Fibromyalgia syndrome - novel therapeutic targets. Maturitas [June 3 Epub ahead of print]. "Fibromyalgia is a syndrome characterized by the presence of chronic widespread pain, representing sensitization of the central nervous system. The pathophysiology of fibromyalgia is complex and remains in evolution, encompassing diverse issues such as disturbed patterns of sleep, altered processing and decreased conditioned pain modulation at the spinal level, as well as increased connectivity between various pain-processing areas of the brain. This evolution is continuously uncovering potential novel therapeutic targets. Treatment of fibromyalgia is a multi-faceted endeavor, inevitably combining pharmacological as well as non-pharmacological approaches. Certain specific ligands and selective nor-epinephrine-serotonin reuptake inhibitors are the current mainstays of pharmacological ...

TY - JOUR. T1 - Assessment of CPM reliability. T2 - quantification of the within-subject reliability of 10 different protocols. AU - Vaegter, Henrik Bjarke. AU - Petersen, Kristian Kjær. AU - Mørch, Carsten Dahl. AU - Imai, Yosuke. AU - Arendt-Nielsen, Lars. PY - 2018/10/25. Y1 - 2018/10/25. KW - conditioned pain modulation. KW - cuff algometry. KW - pain sensitivity. KW - pain threshold. KW - pain tolerance. KW - reliability. KW - test-retest. UR - http://www.scopus.com/inward/record.url?scp=85050669959&partnerID=8YFLogxK. U2 - 10.1515/sjpain-2018-0087. DO - 10.1515/sjpain-2018-0087. M3 - Journal article. VL - 18. SP - 729. EP - 737. JO - Scandinavian Journal of Pain. JF - Scandinavian Journal of Pain. SN - 1877-8860. IS - 4. ER - ...

Health, ...THURSDAY April 14 (HealthDay News) -- Family behavior can influence h...Researchers in Croatia assessed what they refer to as pain catastrophi... We found that parents pain catastrophizing scores predicted their ad... Since during childhood parents serve as a model that children imita...,Kids,May,Mimic,How,Parents,Handle,Pain,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

A 2015 study of 36 chronic pain patients sought to explore the causes of pain-related fear in the hopes of contributing to research

Using small balls and soft foam rollers with techniques from a program called the MELT method, many with fibromyalgia find they can calm their central nervous system down.

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Muscle, Back, Muscles, Spine, Back Pain, Pain, Kinematics, Joint, Low Back Pain, Gravity, Injury, Human, Treatment, Methods, Lifting, Catastrophizing, Depression, Distance, Fear, Men

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Triathletes and ironman triathletes participate in an extremely intense sport that involves hours of considerable pain, in addition to physical and psychological stress, every day. The basic pain modulation properties of these athletes has not been established and for this reason it is not clear whether they present with unique features that make it possible for them to engage in such efforts. This studys goal was to investigate the existence of possible alterations in pain perception and modulation of triathletes, in addition to possible underlying factors. 19 triathletes and 17 non-athletes who underwent measurement of pain threshold, pain tolerance, suprathreshold perceived pain intensity, temporal summation of pain, and conditioned pain modulation (CPM) participated in the study. Participants also completed the fear of pain and the pain catastrophizing questionnaires, and rated the amount of perceived stress. Triathletes exhibited higher pain tolerance (P,.0001), lower pain ratings ...

The broad aim of the study is to implement and evaluate the efficacy of Graded Exposure Treatment (GET Living) to target elevated pain-related fears in children with chronic pain. Pain-related fear is an important psychological factor associated with poor outcomes in children suffering with chronic pain. To examine the efficacy of GET Living in addressing pain-related fears the investigators propose to use a sequential replicated randomized single-case experimental phase design with multiple measures. The specific aims are to 1) evaluate the effectiveness and acceptability of individually tailored GET Living for children with high pain-related fear and functional disability and 2) define anatomical and resting state connectivity patterns in the brains of children and adolescents with complex chronic pain prior to and after participation in GET Living ...

The etiology of severe fatigue in T1DM is not well understood. It seems obvious that physiological diabetes-related factors such as haemoglobin A1c (HbA1c) levels or variations in blood glucose levels are associated with fatigue. While fatigue is a classical presenting symptom of hyperglycaemia, in our cross-sectional study no relationship between glucose control (HbA1c levels) and fatigue severity was found [3]. Also, parameters gathered during continuous glucose monitoring such as the blood glucose variability were unrelated to persistent fatigue. Other diabetes-related factors were correlated to fatigue: the number of complications due to diabetes, diabetes-related distress and diabetes specific self-efficacy. Also, there was a univariate relationship between fatigue and somatic comorbidity. In a multiple regression, several cognitive behavioural factors were found to be potential determinants of fatigue: disrupted sleep-wake patterns, low physical activity, catastrophising thoughts about ...

The effect of dispositional optimism on recovery from coronary artery bypass surgery was examined in a group of 51 middle-aged men. Patients provided information at three points in time--(a) on the day before surgery, (b) 6-8 days postoperatively, and (c) 6 months postoperatively. Information was obtained relating to the patients rate of physical recovery, mood, and

Analyzed data on subset of respondents with chronic pain from the National Survey of Midlife in the United States (MIDUS). Results indicated trait and state feelings of positive affect were associated with changes in levels of salivary cortisol.Analyzed GIS and daily diary data from a pilot study of chronic pain. Results indicated that exposure to nearby nature buffered the effects of pain catastrophizing on pain intensity.Examined the relationship of perceived control over daily uplifts and hassles in a sample of individuals with chronic pain. Results indicated that greater control over uplifts was associated with more adaptive pain outcomes and lower control over hassles with poorer functioning ...

Fibromyalgia and depression often go hand in hand, and a new study finds that the drug Lyrica helps ease pain in patients being treated for both conditions.

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

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All about signs & symptoms of fibromyalgia commonly found in people suffering from fibromyalgia disease. Fibromyalgia symptom checklist for fibromyalgia patients.

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God] frustrates the devices of the crafty, so that their hands achieve no success. [God] takes the wise in their own craftiness; and the schemes of the wily are brought to a quick end. They meet with darkness in the daytime, and grope at noonday as in the night. But [God] saves the needy from the sword of their mouth, from the hand of the mighty. So the poor have hope, and injustice shuts its mouth ...

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Results from studies of the impact of psychological stress on breast cancer risk have been inconsistent, possibly due to differences in subjective responses to similar stressful events. Dispositional optimism, characterized by the general belief that good things will happen in ones life, is correlated with better adjustment to diverse stressors and psychological wellbeing. Limited numbers of studies suggest that the benefit of optimism may also extend to physical health. The purpose of the present analysis was to examine psychosocial and behavioral correlates of dispositional optimism and to determine whether optimism is a protective factor for breast cancer in a large cohort of women aged 35-74 years.. Data came from the Sister Study, a prospective cohort of 50,884 women with a sister with breast cancer. Optimism was assessed among 46,776 women (92%) at the first biennial follow-up interview using the 6-item Life Orientation Test -Revised (LOT-R). After excluding 1,009 women diagnosed with ...

TY - JOUR. T1 - Reduced selective learning in patients with fibromyalgia vs healthy controls. AU - Meulders, Ann. AU - Boddez, Yannick. AU - Blanco, Fernando. AU - Van Den Houte, Maaike. AU - Vlaeyen, Johan W S. PY - 2018/7. Y1 - 2018/7. N2 - Impaired selective fear learning has been advanced as a core mechanism involved in excessive spreading of protective responses such as pain-related fear and avoidance leading to disability in chronic pain conditions. Using the litmus test for selective learning effects, the blocking procedure, we tested the hypothesis that patients with fibromyalgia (FM) show less selective threat learning than healthy controls (HCs). We introduce a novel selective learning task based around a clinical diary scenario. On a trial-by-trial basis, participants rated whether they expected certain situations (A, B, Z, and X) in the diary of a fictive FM patient would trigger pain in that patient. The procedure did not involve any experimental pain induction because the verbal ...

Results Serum TNF-α, IL-1β, IL-8 and oxidized LDL were not statistically different between patient and healthy control groups (p values; p=0,144; p=0,284; p=0,186; p=0,379; respectively). No statistically significant difference was found between FIQ scores and parameters including serum TNF-α, IL-1β, IL-8, oxidized LDL (p values; p=0,066; p=0,885; p=0,061; p=0,453; respectively). Relationship among NTP and serum proinflammatory cytokines (TNF-α, IL-1β, IL-8) and oxidized-LDL levels were not statistically significant (p values; p=0,502; p=0,285; p=0,261; p=0,600; respectively). VAS did not have statistically significant relationship with serum IL-1β and oxidized LDL (p values; p=0,243; p=0,154; respectively); but relationship between serum IL-8 ve TNF-α was statistically significant (p values; p=0,043; p=0,021; respectively). In addition the SSS had significant relationship with serum oxidized LDL in patient group (p=0,006). ...

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Overall, Fibromyalgia is a complex disorder that can be managed, but not cured. Lets take a look at how taking massage classes can help Fibromyalgia patients.

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Weather has been known to bother Fibromyalgia patients. Most seem to feel extra pain from the cold. Sun is another problem, besides the brightness hurting your eyes, for me it feels as it the sun is burning my skin. I have always been sun sensitive, but sometimes I have difficulty within moments of entering a…

Does anyone know if the FDA has approved the APA Assay kit (Anti-polymer antibody assay) to diagnose FIbromyalgia patients. I know the autoimmune technologies LLC is doing FDA clinical trial on this ...

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Until they get to a cause, Dr. Hornig is unwilling to rule out any possibilities. ME/CFS could be caused by an immune response to a wide range of pathogens (which may be present or not) or to an as yet undiscovered agent. That statement suggested that Dr. Hornig doesnt consider the earlier CII study which found little or no evidence of pathogens to be the end of the story.. Of course few researchers have looked in the tissues. Dr Chia believes hes found enteroviruses and Dr. Duffy herpesviruses in the gut tissues of ME/CFS and/or fibromyalgia patients. Hornig and Lipkin have looked in the blood but theyre also raising money to do analyses of the flora in the stool and saliva over time. (Check out the Microbe Discovery Project for more.) Plus, as weve seen, a Simmaron/Konstance Knox project is looking for evidence of insect borne illnesses that have not been tested for before.. If pathogens are involved, the heterogeneity in the disease could reflect genetic differences in how each person ...

Since ME/CFS & Fibromyalgia patients seem to have such a wide variety and severity of symptoms, I thought I would list mine here so that readers of my site would understand my personal perspective on the diseases and understand that my experience may be very different from their own or those they know.

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As I continued to read, however, this quote by the Smithsonians Deborah Tulani Salahu-Din struck me: "[The work] focuses also on the social, political and economic injustices that have been with us for quite some time." She did not mention educational injustices.. ...

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How strange. Why didnt he run and save his own hide? What made him go back? Is it possible that he loved her? Is it possible that he wanted to hold her in his arms one last time? Is it possible that he needed to cry and grieve? Is it possible that he felt the stupidity of war? Is it possible that he felt the injustice of fate? Is it possible that he thought of children, born or unborn? Is it possible that he didnt care what became of him now ...

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Today I thought I would provide some tips for those of you who would like to one day become the biggest jerk in your office. Well use examples of some injustices that befell me today before lunch ...

Abstract Background Pain after surgery is not uncommon with 30% of patients reporting moderate to severe postoperative pain. Early identification of patients prone to postoperative pain may be a step forward towards individualized pain medicine providing a basis for improved clinical management through treatment strategies targeting relevant pain mechanisms in each patient. Assessment of pain processing by quantitative sensory testing (QST) prior to surgery has been proposed as a method to identify patients at risk for postoperative pain, although results have been conflicting. Since the last systematic review, several studies investigating the association between postoperative pain and more dynamic measures of pain processing like temporal summation of pain and conditioned pain modulation have been conducted. Objectives According to the PRISMA guidelines, the aim of this systematic review was to evaluate whether assessment of experimental pain processing including measures of central pain mechanisms

Nurses are at increased risk for job burnout, which can lead to psychological and physical problems, decreased quality of care, and premature exit from the profession. Studies have found common predictors of burnout in multiple service occupations, but there are important differences across settings. The current study used embedded mixed-method analyses to explore burnout in a sample of nurses that work with patients with chronic abdominal pain. Thirty-two nurses participated in focus groups and data analyses revealed the following six themes: negative pain beliefs, barriers to effective pain management, nurse empathy/compassion, moral distress, coping methods, and burnout. These themes were evaluated with proposed theoretical frameworks and the extant literature to build the Pediatric Chronic Pain Nurse Burnout model. The constructs in this model were then evaluated quantitatively via measures completed by 41 nurses. Analyses provided partial support for the model and highlighted areas for further

Dr. Irfan Suleman is an assistant professor of Anesthesiology and Critical Care Medicine at the Johns Hopkins School of Medicine. His areas of clinical expertise include Pediatric Anesthesia and Pediatric Pain Management. He is a nationally and internationally recognized physician in these fields. Dr. Suleman also serves as the Director of Pediatric Regional Anesthesia, the Director of Pediatric Chronic Pain Interventional Management at the Johns Hopkins Childrens Center and the Medical Director of Multidisciplinary Pediatric Pain Rehabilitation Program at Kennedy Krieger Institute.

The research on fibromyalgia is clearly lost and in need of overhaul. It suffers from too much incoherentism. It truly is an example of the blind men looking at the elephant.. New models and approaches are needed to better understand and address fibromyalgia. The neurocentric model is now popular- for medicine has failed with the traditional biomedical model and wish to see painful conditions as a result of a defective brain/mind/personality. And so medicine, once again, stigmatizes people in pain by trying to define fibromyalgia as a result of a defective mind- which is a thinly veiled way of saying that people with fibromyalgia have a defective personality. And so when medications for fibromyalgia dont work or dont work well medicine can explain it away as the result of the defective personality of the person with fibro. And we know that, despite no real understanding of cbt or the work of Albert Ellis the pain specialists have labeled all people in pain as "catastrophizers". And having worked ...

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Pain Manag Nurs. 2019 May 10. pii: S1524-9042(18)30157-7. doi: 10.1016/j.pmn.2018.10.002. [Epub ahead of print]Acceptability and Feasibility of a Mindfulness-Based Intervention for Pain Catastrophizing among Persons with Sickle Cell Disease.Simmons LA1, Williams H2, Silva S3, Keefe F4, Tanabe P5.AbstractBACKGROUND:Few investigators have developed and tested nonpharmacological interventions for helping persons with sickle cell disease (SCD) manage persistent pain.AIMS:The purpose of this pilot study was to examine the feasibility and acceptability of a mindfulness-based intervention (MBI) in adults with SCD and chronic pain and to gather preliminary data on its efficacy.DESIGN:Data on feasibility and acceptability, including recruitment, retention, and attendance rates, were collected during a single-site, randomized control trial. Participants were randomly assigned to either a 6-session group telephonic MBI or a wait-listed control. Pain catastrophizing was assessed at baseline and at weeks 1, ...

Despite an elusive pathophysiology, common characteristics are often observed in individuals with chronic low back pain (LBP). These include psychological symptoms, altered pain perception, altered pain modulation and altered muscle activation. These factors have been explored as possible determinants of disability, either separately or in cross-sectional studies, but were never assessed in a single longitudinal study. Therefore, the objective was to determine the relative contribution of psychological and neurophysiological factors to future disability in individuals with past LBP. The study included two experimental sessions (baseline and six months later) to assess cutaneous heat pain and pain tolerance thresholds, pain inhibition, as well as trunk muscle activation. Both sessions included the completion of validated questionnaires to determine clinical pain, disability, pain catastrophizing, fear-avoidance beliefs and pain vigilance. One hundred workers with a history of LBP and 19 healthy ...

Patellofemoral Pain (PFP) is highly prevalent among adults and adolescents. Localized mechanical hyperalgesia around the knee and tibialis anterior have been observed in people with PFP, but limited knowledge of potential manifestations of central sensitisation exists. The aims of this study were to study conditioned pain modulation (CPM) and wide-spread hyperalgesia in adults with PFP. This assessor-blinded cross-sectional study design compared CPM and mechanical pressure pain thresholds (PPT) between 33 adults (23 females) diagnosed with PFP and 32 age and sex matched pain-free controls. The investigator taking the PPT measurements was blinded to which participants had PFP. PPTs were reliably measured using a Somedic hand-held pressure algometer at three sites: 1) The centre of the patella, 2) the tibialis anterior muscle and 3) a remote site on the lateral epicondyle. For the assessment of CPM, experimental pain was induced to the contralateral hand by immersion into a cold water bath ...