Cataplexy: A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)Neuropeptides: Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.Hypersomnolence, Idiopathic: A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)Sleep Paralysis: A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)Wit and Humor as Topic: The faculty of expressing the amusing, clever, or comical or the keen perception and cleverly apt expression of connections between ideas that awaken amusement and pleasure. (From Random House Unabridged Dictionary, 2d ed)HLA-DQ beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.Sleep, REM: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.Sodium Oxybate: The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.Intracellular Signaling Peptides and Proteins: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.Orexin Receptors: G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)Sleep Stages: Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.Polysomnography: Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.Wakefulness: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.Emotional Intelligence: The ability to understand and manage emotions and to use emotional knowledge to enhance thought and deal effectively with tasks. Components of emotional intelligence include empathy, self-motivation, self-awareness, self-regulation, and social skill. Emotional intelligence is a measurement of one's ability to socialize or relate to others.Muscle Hypotonia: A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.HLA-DQ Antigens: A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.Receptors, Neuropeptide: Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Pons: The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.Hypothalamic Hormones: Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Salicylamides: Amides of salicylic acid.Laughter: An involuntary expression of merriment and pleasure; it includes the patterned motor responses as well as the inarticulate vocalization.Catalepsy: A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.Arousal: Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.Chronology as Topic: The temporal sequence of events that have occurred.Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)Paralysis: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Baths: The immersion or washing of the body or any of its parts in water or other medium for cleansing or medical treatment. It includes bathing for personal hygiene as well as for medical purposes with the addition of therapeutic agents, such as alkalines, antiseptics, oil, etc.Appointments and Schedules: The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.Trust: Confidence in or reliance on a person or thing.Prefrontal Cortex: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.Rickettsiaceae: A family of small, gram-negative organisms, often parasitic in humans and other animals, causing diseases that may be transmitted by invertebrate vectors.Williams Syndrome: A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Amygdala: Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.Anoxia: Relatively complete absence of oxygen in one or more tissues.Chemoreceptor Cells: Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.Pulmonary Ventilation: The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Autonomic Nervous System Diseases: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Restless Legs Syndrome: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.Torture: The intentional infliction of physical or mental suffering upon an individual or individuals, including the torture of animals.Nocturnal Myoclonus Syndrome: Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Adjuvants, Anesthesia: Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.Pharmacy Service, Hospital: Hospital department responsible for the receiving, storing, and distribution of pharmaceutical supplies.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Rape: Unlawful sexual intercourse without consent of the victim.Parental Consent: Informed consent given by a parent on behalf of a minor or otherwise incompetent child.ArchivesMinors: A person who has not attained the age at which full civil rights are accorded.Papillomavirus Vaccines: Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Child Advocacy: Promotion and protection of the rights of children; frequently through a legal process.Arecaceae: The palm family of order Arecales, subclass Arecidae, class Liliopsida.Parental Notification: Reporting to parents or guardians about care to be provided to a minor (MINORS).Abortion, Legal: Termination of pregnancy under conditions allowed under local laws. (POPLINE Thesaurus, 1991)Suburban Health Services: Health services, public or private, in suburban areas. The services include the promotion of health and the delivery of health care.Central Nervous System Agents: A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Technology Assessment, Biomedical: Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Renin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.Guideline Adherence: Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Dominica: An island republic of the West Indies. Its capital is Roseau. It was discovered in 1493 by Columbus and held at different times by the French and the British in the 18th century. A member of the West Indies Federation, it achieved internal self-government in 1967 but became independent in 1978. It was named by Columbus who discovered it on Sunday, Domingo in Spanish, from the Latin Dominica dies, the Lord's Day. (From Webster's New Geographical Dictionary, 1988, p338 & Room, Brewer's Dictionary of Names, 1992, p151)Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)Expert Systems: Computer programs based on knowledge developed from consultation with experts on a problem, and the processing and/or formalizing of this knowledge using these programs in such a manner that the problems may be solved.Manuscripts as Topic: Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.Hysterectomy: Excision of the uterus.Ferritins: Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.Hysterectomy, Vaginal: Removal of the uterus through the vagina.Congenital Hypothyroidism: A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA.Anemia, Iron-Deficiency: Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Thyrotropin: A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.

Unilateral cataplexy associated with systemic lupus erythematosus. (1/120)

A patient with systemic lupus erythematosus (SLE) developed attacks of unilateral cataplexy precipitated by laughter. Unilateral cataplexy has not been described previously in detail and its association with SLE is unique. The clinical details, investigations, and diagnostic criteria are discussed and a causal relationship between cataplexy and SLE is suggested.  (+info)

Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy. (2/120)

Cataplexy, an abnormal manifestation of REM sleep atonia, is currently treated with antidepressants. These medications also reduce physiological REM sleep and induce nocturnal sleep disturbances. Because a recent work on canine narcolepsy suggests that the mechanisms for triggering cataplexy are different from those for REM sleep, we hypothesized that compounds which act specifically on cataplexy, but not on REM sleep, could be developed. Canine studies also suggest that the dopamine D2/D3 receptor mechanism is specifically involved in the regulation of cataplexy, but little evidence suggests that this mechanism is important for REM sleep regulation. We therefore assessed the effects of sulpiride, a commonly used D2/D3 antagonist, on cataplexy and sleep in narcoleptic canines to explore the possible clinical application of D2/D3 antagonists for the treatment of human narcolepsy. Both acute and chronic oral administration of sulpiride (300 mg/dog, 600 mg/dog) significantly reduced cataplexy without noticeable side effects. Interestingly, the anticataplectic dose of sulpiride did not significantly reduce the amount of REM sleep. Sulpiride (and other D2/D3 antagonists) may therefore be an attractive new therapeutic indication in human narcolepsy.  (+info)

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. (3/120)

Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence that additional HLA class II alleles have on susceptibility to this disease. In this work, 1,087 control subjects and 420 narcoleptic subjects with cataplexy, from three ethnic groups, were HLA typed, and the effects of HLA-DRB1, -DQA1, and -DQB1 were analyzed. As reported elsewhere, almost all narcoleptic subjects were positive for both HLA-DQA1*0102 and -DQB1*0602. A strong predisposing effect was observed in DQB1*0602 homozygotes, across all ethnic groups. Relative risks for narcolepsy were next calculated for heterozygous DQB1*0602/other HLA class II allelic combinations. Nine HLA class II alleles carried in trans with DQB1*0602 were found to influence disease predisposition. Significantly higher relative risks were observed for heterozygote combinations including DQB1*0301, DQA1*06, DRB1*04, DRB1*08, DRB1*11, and DRB1*12. Three alleles-DQB1*0601, DQB1*0501, and DQA1*01 (non-DQA1*0102)-were found to be protective. The genetic contribution of HLA-DQ to narcolepsy susceptibility was also estimated by use of lambda statistics. Results indicate that complex HLA-DR and -DQ interactions contribute to the genetic predisposition to human narcolepsy but that additional susceptibility loci are also most likely involved. Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy.  (+info)

Health-related quality of life in narcolepsy. (4/120)

Narcolepsy is a chronic sleep disorder characterised by symptoms of excessive daytime sleepiness and cataplexy. The aim of this study was to describe the health-related quality of life of people with narcolepsy residing in the UK. The study comprised a postal survey of 500 members of the UK narcolepsy patient association, which included amongst other questions the UK Short Form 36 (SF-36), the Beck Depression Inventory (BDI), and the Ullanlinna Narcolepsy Scale (UNS). A total of 305 questionnaires were included in the final analysis. The results showed that the subjects had significantly lower median scores on all eight domains of the SF-36 than normative data, and scored particularly poorly for the domains of role physical, energy/vitality, and social functioning. The BDI indicated that 56.9% of subjects had some degree of depression. In addition, many individuals described limitations on their education, home, work and social life caused by their symptoms. There was little difference between the groups receiving different types of medication. This study is the largest of its type in the UK, although the limitations of using a sample from a patient association have been recognised. The results are consistent with studies of narcolepsy in other countries in demonstrating the extensive impact of this disorder on health-related quality of life.  (+info)

Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area. (5/120)

Orexin-A (OX-A) and orexin-B (OX-B) (hypocretin 1 and hypocretin 2) are synthesized in neurons of the perifornical, dorsomedial, lateral, and posterior hypothalamus. The locus coeruleus (LC) receives the densest extrahypothalamic projections of the orexin (OX) system. Recent evidence suggests that descending projections of the LC have a facilitatory role in the regulation of muscle tone. The pontine inhibitory area (PIA), located ventral to LC, receives a moderate OX projection and participates in the suppression of muscle tone in rapid-eye-movement sleep. We have examined the role of OX-A and -B in muscle-tone control using microinjections (0.1 microM to 1 mM, 0.2 microl) into the LC and PIA in decerebrate rats. OX-A and -B microinjections into the LC produced ipsi- or bilateral hindlimb muscle-tone facilitation. The activity of LC units was correlated with the extent of hindlimb muscle-tone facilitation after OX microinjections (100 microM, 1 microl) into fourth ventricle. Microinjections of OX-A and -B into the PIA produced muscle-tone inhibition. We did not observe any significant difference in the effect of OX-A and -B on muscle tone at either site. Our data suggest that OX release activates LC units and increases noradrenergic tonus in the CNS. Moreover, OX-A and -B may also regulate the activity of pontine cholinoceptive and cholinergic neurons participating in muscle-tone suppression. Loss of OX function may therefore disturb both facilitatory and inhibitory motor processes.  (+info)

MAO-A and COMT polymorphisms and gene effects in narcolepsy. (6/120)

Narcolepsy presents one of the tightest associations with a specific HLA antigen (DQB1*0602) but there is strong evidence that non-HLA genes also confer susceptibility. Recent observations have implicated the hypocretin/orexin system in narcolepsy in both humans and animals. In addition, the implication of monoaminergic systems in the pathophysiology of narcolepsy is well established and a significant association between the monoamine oxydase-A (MAO-A) gene and human narcolepsy has recently provided a possible genetic link. We investigated polymorphisms of MAO-A and catechol-O-methyltransferase (COMT) in 97 Caucasians with well-defined narcolepsy-cataplexy and sought for genotypic effects on disease symptoms. No evidence of association between genotype or allele frequencies of both MAO-A or COMT gene and narcolepsy was found. However, a sexual dimorphism and a strong effect of COMT genotype on disease severity were found. Women narcoleptics with high COMT activity fell asleep twice as fast as those with low COMT activity during the multiple sleep latency test (MSLT) while the opposite was true for men. COMT genotype also strongly affected the presence of sleep paralysis and the number of REM sleep onsets during the MSLT. In agreement with well-documented pharmacological results in canine narcolepsy, this study reports the first genetic evidence for the critical involvement of the dopaminergic and/or noradrenergic systems in human narcolepsy.  (+info)

Childhood onset of narcolepsy-cataplexy syndrome in Turkey: clinical and genetic study. (7/120)

Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleepiness and abnormal manifestations of rapid eye movement (REM) sleep including cataplexy, sleep paralysis and hypnagogic hallucinations. It is known to be complex disorder in which both genetic predisposition and environmental factors play a role. In humans, susceptibility to narcolepsy is tightly associated with a specific HLA allele, DQB1*0602. In this report, we took advantage of the ongoing genetic study in Turkish narcoleptic patients to document clinical and genetic data of eight patients whose onset of symptoms were in the childhood period.  (+info)

Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia. (8/120)

The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy, and unusually rapid transitions to rapid eye movement sleep, opens a new field of investigation in the area of disorders of sleep and activation. Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) (also called orexin-A and orexin-B) are newly discovered neuropeptides processed from a common precursor. Hypocretin containing cells are located exclusively in the lateral hypothalamus, with widespread projections within the central nervous system. The role of the hypocretin system in other disorders causing excessive daytime sleepiness is more uncertain. This study reports the findings of a prospective study measuring cerebrospinal fluid concentrations of hypocretin-1 and hypocretin-2 in HLA DQB1*0602 positive narcolepsy with cataplexy, monosymptomatic narcolepsy, and primary hypersomnia. The results confirmed the previous observations, that hcrt-1 is deficient in narcolepsy and for the first time report very low levels of hcrt-1 in primary hypersomnia. It is also reported for the first time that there is a generalised defect in hcrt-2 transmission in all three of these clinical entities compared with controls.  (+info)

*Cataplexy

... without narcolepsy is rare and the cause is unknown. The term cataplexy originates from the Greek κατά (kata, meaning ... Secondary cataplexy is associated with specific lesions located primarily in the lateral and posterior hypothalamus. Cataplexy ... "Causes of Cataplexy". Demand Media, Inc. Retrieved April 30, 2012. ASA. "About Narcolepsy / Cataplexy". Retrieved July 26, 2016 ... Cataplexy is considered secondary when it is due to specific lesions in the brain that cause a depletion of the hypocretin ...

*Idiopathic hypersomnia

It has been shown to promote deep sleep and improve daytime sleepiness (as well as cataplexy) in patients with narcolepsy; ... Whereas narcolepsy is associated with cataplexy and sleep-onset REM episodes, and Kleine-Levin syndrome is associated with ... The prevalence of narcolepsy (with cataplexy) is estimated between 1/3,300 and 1/5,000. Although the true prevalence of ... See Prognosis section below). Unlike narcolepsy with cataplexy, which has a known cause (autoimmune destruction of hypocretin- ...

*Narcolepsy

... it further divides narcolepsy into that with cataplexy and that without cataplexy. This ICSD version defines narcolepsy as a ... Cataplexy is an episodic loss of muscle function, ranging from slight weakness such as limpness at the neck or knees, sagging ... Cataplexy also has a severe emotional impact on narcoleptics, as it can cause extreme anxiety, fear, and avoidance of people or ... Cataplexy may be mistaken for seizures. While there is no cure, a number of lifestyle changes and medications may help. ...

*Laughter-induced syncope

Unlike syncope, there is no loss of consciousness in cataplexy, which affects some sufferers of narcolepsy. To date there have ... Laughter-induced syncope should not be confused with cataplexy, a sudden loss of muscle tone triggered by strong emotions, ... "Characterizing the Emotions That Trigger Cataplexy". Journal of Neuropsychiatry and Clinical Neurosciences. American ...

*Sodium oxybate

The American Academy of Sleep Medicine (AASM) recommends sodium oxybate as a standard of care for the treatment of cataplexy, ... In 2002, sodium oxybate received approval from the FDA for the treatment of cataplexy in patients with narcolepsy. In 2005, the ... Also that year sodium oxybate was approved for the treatment of cataplexy in patients with narcolepsy by Health Canada's ... In 2006, sodium oxybate received an expanded indication for narcolepsy with cataplexy in the EU. In 2010, Jazz Pharmaceuticals ...

*Clomipramine

Body dysmorphic disorder Cataplexy associated with narcolepsy. Which is a TGA and MHRA-labeled indication for clomipramine. ...

*Zimelidine

... was reported by Montplaisir and Godbout to be very effective for cataplexy in 1986, back when this was usually ... Zimelidine was able to improve cataplexy without causing daytime sleepiness. Most often reported were: Dry mouth, dryness of ... Godbout R, Montplaisir J.; Montplaisir (1986). "The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and ...

*Hypersomnia

... with and without cataplexy); idiopathic hypersomnia; and recurrent hypersomnias (like Klein-Levin syndrome). There are also ...

*H3 receptor antagonist

Cataplexy, hypnagogic hallucinations and sleep paralysis can also be present in narcolepsy. H3R antagonism leads to histamine ...

*Prader-Willi syndrome

"Case Study: Cataplexy and SOREMPs Without Excessive Daytime Sleepiness in Prader Willi Syndrome. Is This the Beginning of ...

*Viloxazine

It was never approved by the FDA, but the FDA granted it an orphan designation (but not approval) for cataplexy and narcolepsy ... In narcolepsy, viloxazine has been shown to suppress auxiliary symptoms such as cataplexy and also abnormal sleep-onset REM ... In a cross-over trial (56 participants) viloxazine significantly reduced EDS and cataplexy. Viloxazine has also been studied ...

*Clinical neurochemistry

Cataplexy, on the other hand, is an involuntary loss of muscle tone during wakefulness. The mechanism of narcolepsy is unknown ...

*Human leukocyte antigen

"Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups". The American Journal of Human ...

*Carl Friedrich Otto Westphal

"English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th ... He was the first physician to provide a clinical description of narcolepsy and cataplexy (1877). French physician Jean-Baptiste ...

*Squalene

"Report from a case inventory study on Pandemrix vaccination and development of narcolepsy with cataplexy" (PDF). Euro Surveill ...

*Dorsal raphe nucleus

Cataplexy is the symptom of narcolepsy when full awareness of the environment is maintained, but all muscle tone is lost. This ... "Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs". J. Physiol. 554 (Pt 1 ...

*Niemann-Pick disease

Gelastic cataplexy, the sudden loss of muscle tone when the affected patient laughs, is also seen. Mutations in the SMPD1 gene ...

*Mesencephalic locomotor region

... cataplexy, and Parkinsonism". Frontiers in Neurology. 6 (140): 1-13. Sherman, D; Fuller, PM; Marcus, J; Yu, J; Zhang, P; ... cataplexy, and Parkinsonism". Frontiers in Neurology. 6 (140): 1-13. Takakusaki, K; Tomita, N; Yano, M (2008). "Substrates for ...

*Glossary of psychiatry

Cataplexy involves a sudden loss of muscle tone, and is generally precipitated by a sudden emotional response. Catatonia ...

*Seizure types

... but should be distinguished from similar looking attacks that may occur in cataplexy. Status epilepticus refers to continuous ...

*Alternating hemiplegia of childhood

This drug was chosen to test because of a possible link between the causes of narcolepsy-cataplexy and AHC.[citation needed] ... Currently, sodium oxybate is used as a narcolepsy-cataplexy treatment, though in the past it has been used controversially in ...

*Giant Schnauzer

... cataplexy, and various seizure disorders. Some are also sensitive to sulphonamides and gold. Bone diseases and joint problems ...

*Classification of sleep disorders

... with cataplexy G47.419 …… without cataplexy G47.42 Narcolepsy in conditions classified elsewhere G47.421 …… with cataplexy ... cataplexy, Sleep paralysis, Hypnogogic and hypnopompic hallucination G47.48 Other forms of narcolepsy and cataplexy Excl: Other ... Westphal in 1877 described first case of narcolepsy, the name coined later by Gelineu in 1880 in association with cataplexy. ... G47.429 …… without cataplexy G47.50 …… unspecified G47.51 Confusional arousals G47.52 REM sleep behavior disorder G47.53 ...

*Franck Bouyer

Bouyer suffers from narcolepsy, resulting in sudden sleep attacks and cataplexy, and was unable to compete or train without ...

*Lateral hypothalamus

... a recent multicentre case-control study revealed that chronic pain is more common in patients with narcolepsy with cataplexy ...
Cataplexy is estimated to be present in ~70% of Narcolepsy cases, but I had heard that the severe form affects less than 10-15%. It is said that Narcolepsy with Cataplexy, "affects about one in every 3,000 Americans. More cases without Cataplexy are likely to exist.". In the research for this post, I came across "Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy with Cataplexy", where the thresholds are revealed to be from statistical analysis, using R. Where the optimal cutoff for CSF Hypocretin-1, the ROC curve analysis defines a gold standard of approximately 200 pg/mL as the cutoff for the diagnosis of Narcolepsy without Cataplexy vs those with, and is convenient with previously defined cut offs of low (,=110), intermediate (,=200), or normal (>200), where Narcolepsy with Cataplexy are those with 110 pg/ml or less. Intermediate….do we really exist? From what I recall reading (while I was required to lay as still as possible on back follow the spinal tap), those values were again ...
Approximately twenty-five percent of sleep is REM in the young adult [13] but interestingly, this varies with age [14]. We know that infants have much more REM compared to adults, as human infants typically enter REM sleep directly after the initial onset of sleep and spend approximately 50% of their total sleep time in REM [15]. And we also know that as we age, cartilaginous structures desiccate [16]. During development, infants have much more cartilaginous tissue compared to adults while they undergo the metabolic demanding task of endochondral ossification. Chondrocytes constitute the predominant cell of cartilage which is an interface tissue that is avascular, aneural and alymphatic [17]. These cells lay in an environment that is influenced by mechanical forces [18] whereby cellular perception of mechanical stress within cartilaginous tissues is an important modulator of chondrocyte function [19]. Recent understandings of growth plate proliferation have revealed that distraction is ...
Oishi, Y.; Williams, R.H.; Agostinelli, L.; Arrigoni, E.; Fuller, P.M.; Mochizuki, T.; Saper, C.B.; Scammell, T.E., 2013: Role of the medial prefrontal cortex in cataplexy
Trust me, I know it seems weird. I fainted in the shower on Sunday and felt fine Monday but when I called to make an appointment just to get it checked out they asked that I go to the ER, so I did. I was reluctant because it didnt seem like a huge deal -- it was probably just hypotension from the heat -- but everyone else waiting at the ER was also there for something that wasnt obviously immediately killing them. You dont mess around with neurological things, fainting, etc, for good reason. If it was a stroke, which is possible, you need to go get it checked out ASAP. If it wasnt a stroke, you still need to know what it was. No ones going to get angry at you for showing up if it doesnt end up being serious ...
I am 34 and was dxd with Narcolepsy/Cataplexy last year after searching for answers for a very long time. I have white matter and grey matter spots/lesions that are unenhanced with contrast (demyelin...
Association of cataplexy with EDS with another disorder of the brain was first reported in the early 1900. These associations includes tumors, localized most
Narcolepsy is an orphan sleep disorder (0.026% of the general population) characterized by a clinical history of EDS and abnormal manifestations of dissociated REM sleep, such as cataplexy (that is, sudden loss of muscle tone triggered by strong emotions), hypnagogic hallucinations, and sleep paralysis [59]. Narcolepsy typically starts during adolescence, a critical period of normal development and interpersonal relationship building [60]. Cataplexy is the best clinical diagnostic marker for the disease, occurring in 70% to 80% of patients. Two separate entities are individualized: narcolepsy with and without cataplexy [11]. Narcolepsy diagnosis requires nocturnal PSG recording followed by the MSLT, the latter showing a mean sleep latency ,8 minutes and two or more sleep onset REM periods (SOREMPs).. For 120 years after it was identified, narcolepsy was attributed to psychiatric etiologies [61]. In the 2000s, however, it was determined that when cataplexy is present, narcolepsy is almost always ...
There are two kinds of narcolepsy: one with cataplexy, and the other without. Cataplexy is a sudden loss of muscle control when the person can fall or slur their words and is often caused by an emotion such as laughter or some kind of excitement. During cataplexy, the person is awake.. Narcolepsy without cataplexy is often less severe than with cataplexy, and its a sleep disorder that can cause the sudden onset of sleep, sleep paralysis, hallucinations, and excessive sleepiness. It affects around 1 in 2,000 people. People with narcolepsy can be very tired during the day, and have vivid hallucinations and sleep paralysis while falling asleep and waking up. They also have disturbed sleep at night because the brain doesnt go through the normal flow through the different phases of sleep-people with narcolepsy can go directly from waking to REM (rapid eye movement) sleep, bypassing light sleep and deep sleep. ...
Narcolepsy and Cataplexy Symptoms and Treatments in Dogs - Narcolepsy and cataplexy are uncommon disorders of the sleep mechanism in which a dog is excessively sleepy all day (narcolepsy) or experiences sudden muscle paralysis and collapse (cataplecy). Between attacks the dog is completely normal.
To investigate the abnormality of cerebral perfusion in narcoleptics with cataplexy, cerebral perfusion was measured by brain single photon emission computed tomography(SPECT). The difference of cerebral perfusion between narcoleptics and normal controls was tested by statistical parametric mapping(SPM) analysis. Twenty-five narcoleptics with cataplexy and 25 normal controls performed 99mTc-ethylcysteinate dimer brain SPECT study. A night polysomnography and multiple sleep latency test (MSLT) in next day were performed in all patients. Brain SPECT was carried out in all patients and normal controls during waking state. The clinical symptoms and the results of MSLT were concordant to the International Classification of Sleep Disorders criteria for narcolepsy in all patients. The MSLT showed short mean sleep latency(1.69±1.0 min) and 2 - 5 sleep onset REM periods per each patient. The SPM analysis of brain SPECT in narcoleptics with cataplexy showed hypoperfusion in bilateral anterior ...
Narcolepsy is a neurological order with symptoms like cataplexy (a debilitating condition in which a person collapses after strong emotions) and hallucinations. Treatment depends upon the severity of the symptoms of narcolepsy, but usually it is treated with drugs. The causes of narcolepsy are not clearly understood.
Posted on: 26th April 2016. On Wednesday 4th May 2016, the High Court will consider an application by the father of a child for judicial review of a decision by NHS England to refuse funding for a drug Sodium Oxybate (brand name Xyrem®) used to treat narcolepsy. The Court will be asked to intervene to require NHS England to fund the only treatment which has a real prospect of reducing the symptoms of this devastating illness.. The Claimant, X, is a 17 year old woman who has narcolepsy and cataplexy, a serious neurological condition causing disruption to night-time sleep, excessive daytime sleepiness, hypnogogic hallucinations and cataplexy.. Since 2012 the Claimant had been prescribed a range of medications to treat her condition including stimulants to help stay awake during the day, other drugs to assist with night-time sleep and further drugs for cataplexy. Unfortunately none of these were effective and in some cases the drugs caused negative side effects.. In May 2014 the Claimants NHS ...
Have you taken Xyrem within the past two years? Harvard Medical School and Brigham and Womens Hospital is currently conducting interviews to determine how FDA-mandated safety programs impact the prescribing and use of drugs like Xyrem.. Little is known about the impact of such programs on physicians, patients, and manufacturers, including whether they increase prescribing burdens, reduce patient access, enhance costs, or improve patients experiences with their illnesses. This study will seek to answer these questions. Participation will involve a 60-minute interview. Upon successful conclusion of the interview, study participants will receive a $50 Amazon gift card.. If you have received Xyrem within the past two years, you may be eligible. For more information, please contact the study principal investigator, Dr. Ameet Sarpatwari at [email protected].. Research Study is Enrolling to Evaluate Medications for Excessive Daytime Sleepiness ...
DISEASE: Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by mutations affecting the gene represented in this entry ...
I dont know if my RLS has changed, I know that I had previously, years ago, had a very bad case, which this previous regimine controlled for years. When I went off of all the drugs it was torture, but when I started the xyrem it was amazing, for the first time I really slept (narcolptics dont get any slow wave sleep, and have many abnormal rem onsets in sleep, etc). And then my whole life changed in the months after xyrem, whereas before I couldnt work or drive, now I could. It didnt just help my cataplexy it gor rid of the completly debilitating sleepiness of narcolepsy. Yes my RLS may have changed, but because I am now facing a situation where I could loose my livilhood, my dr said ok, lets just go back to the old regimne. The thing is it is helping the rls, and I am getting to seep, as I said before, but now Im tired today, and have been for the last 3 days, but I think Im not getting quality sleep, so tonight I will try backing off the xyrem...Im on the top dose, and see i thats ...
TY - JOUR. T1 - Narcolepsy. AU - Thorpy, Michael J.. PY - 2007/6. Y1 - 2007/6. N2 - Narcolepsy is a neurologic disorder that is incurable and therefore requires lifelong treatment. Excessive daytime sleepiness is the most common symptom and can be partially controlled by medications. The pathognomonic symptom of narcolepsy is cataplexy, emotionally induced muscle weakness, which can be the most disabling symptom for many patients. Also, hallucinations that typically occur at sleep onset or muscle paralysis that occurs upon awakening from sleep, called sleep paralysis, occur in many patients. Additional symptoms include fragmented nocturnal sleep and episodes of automatic behavior. Narcolepsy typically has its onset in the first 2 decades of life and may commonly be misdiagnosed. It produces reduced quality of life and, because of the sleepiness, can interfere with memory, concentration, and other cognitive abilities. The cataplexy may predispose the patient to injury because of the muscle ...
Narcolepsy is a chronic neurological disorder with unknown exact cause. Symptoms include periods of excessive daytime sleepiness that usually last from seconds to minutes and may occur at any time. About 70% of people also experience episodes of sudden loss of muscle strength, known as cataplexy. These spells can be brought on by strong emotions. Less commonly there may be inability to move or vivid hallucinations while falling asleep or waking up. People with narcolepsy tend to sleep about the same number of hours per day as people without, but the quality of sleep tends to be worse.. Diagnostic tests are carried out in the sleep clinic in order to measure each of these symptoms, thereby confirming presence of narcolepsy in patients. Diagnosis can be confirmed by polysomnography (Pic. 1) for assessing night-time sleep followed by a multiple sleep latency test to evaluate daytime sleep attacks lasting for a short period of time (Pic. 2). Mild cases of narcolepsy can be managed with regular naps, ...
Sleep Disorders. Narcolepsy. INtroduction to narcolepsy. what is narcolepsy? Causes of narcolepsy. How narcolepsy affects peoples lives?
According to the DSM-5, (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), narcolepsy is a disorder in which the individual will experience recurrent periods of an irresistible need to sleep, or will fall asleep, or nap within the same day, regardless of whether or not the time and place are appropriate. These episodes must occur at least three times per week over the past three months, accompanied by at least one of the following symptoms:. 1. Episodes of cataplexy, or loss of muscle tonus, occurring several times a month, episodes lasting seconds to minutes of sudden full body loss of skeletal muscle tone without LOC (Loss Of Consciousness) that are precipitated by an episode of strong emotion. 2. In children or in individuals "within six months of narcolepsy onset, involuntary grimacing or jaw-opening with tongue thrusting, or hypotonia", in the absence of clear emotional triggers.3. Objective measure of hypocretin deficiency in the cerebrospinal fluid (CSF) as defined by ...
We are clinician scientists board certified both in Sleep Medicine and Neurology with a combined 30 years of clinical experience that includes a particular focus on narcolepsy and related disorders collectively referred to as the "central hypersomnias". We are well published in the area and regularly participate in the annual patient conferences of the Narcolepsy Network. We join with our patients in thanking you for your effort to reach out for input regarding the disease state(s) and especially the unmet needs of the patients who we treat. Having viewed the webcast of the recent September 24th public meeting on narcolepsy patient-focused drug development, we would like to add our voice to those of others.. Excessive daytime sleepiness remains common and the socioeconomic burden to the individual, family, and society is large. Unfortunately, while routine sleep laboratory testing for genuine narcolepsy with cataplexy is sensitive, it is becoming clear that it is highly nonspecific. The ...
What I meant about "making yourself faint" was...Can you manufacture a situation where you are certain to faint. Such as standing up fast, bending over etc. Have you ever fainted at the doctors office? I think You need to be hospitalized, hooked up to a monitor, blood pressure and oxygen saturation machines etc. Your physical parameters should change if you have witnessed syncope. (fainting). Narcolepsy as a possible diagnosis is interesting, as a symptom of it is called cataplexy. "The most severe attacks result in a complete loss of tone in all voluntary muscles, leading to total physical collapse in which patients are unable to move, speak, or keep their eyes open. But even during the most severe episodes, people remain fully conscious, a characteristic that distinguishes cataplexy from seizure disorders. Although cataplexy can occur spontaneously, it is more often triggered by sudden, strong emotions such as fear, anger, stress, excitement, or humor. Laughter is reportedly the most frequent ...
Narcolepsy is being treated with stimulant drugs (amphetamines or methylphenidate) to control the excessive daytime sleepiness and sleep attacks, and imipramine to manage auxiliary symptoms, particularly cataplexy (1). The potentials for tolerance and dependence with the stimulants and cardiotoxicity from imipramine underscore the need for other therapies.. In 1978, we administered propranolol to a narcoleptic patient to treat premature ventricular contractions; a detailed report has been published elsewhere (2). When a relatively low dose of propranolol reduced the frequency of narcoleptic and cataplectic attacks, we gradually increased the dose. At a daily dose of about 300 mg, the attacks were ...
BACKGROUND: Several cross-sectional studies have suggested that subjects with narcolepsy have increased body mass index (BMI) and insulin resistance. These subjects exhibit a decrease in cerebrospinal fluid (CSF) orexin levels, which has been causally linked to the clinical manifestations of this disease. Orexins are peptides expressed in a brain region, the lateral hypothalamic area, which stimulate appetite and modulate sleep. Low CSF orexin levels provoke narcolepsy-like behavior, such as excessive daytime sleepiness and a sudden loss of muscle tone known as cataplexy.. OBJECTIVES: The primary objective of this study is to determine whether subjects with narcolepsy have lower energy expenditure compared to healthy matched controls. In addition, we will assess food intake, physical activity, and other relevant parameters.. STUDY POPULATION: 18 to 55 year old men and premenopausal women with narcolepsy and healthy matched controls. DESIGN: This is a cross-sectional, case-controlled study of ...
BACKGROUND: Several cross-sectional studies have suggested that subjects with narcolepsy have increased body mass index (BMI) and insulin resistance. These subjects exhibit a decrease in cerebrospinal fluid (CSF) orexin levels, which has been causally linked to the clinical manifestations of this disease. Orexins are peptides expressed in a brain region, the lateral hypothalamic area, which stimulate appetite and modulate sleep. Low CSF orexin levels provoke narcolepsy-like behavior, such as excessive daytime sleepiness and a sudden loss of muscle tone known as cataplexy.. OBJECTIVES: The primary objective of this study is to determine whether subjects with narcolepsy have lower energy expenditure compared to healthy matched controls. In addition, we will assess food intake, physical activity, and other relevant parameters.. STUDY POPULATION: 18 to 55 year old men and premenopausal women with narcolepsy and healthy matched controls. DESIGN: This is a cross-sectional, case-controlled study of ...
Press release by THL, Finnish National Institute of Health and Welfare. 1 Feb 2011 http://www.thl.fi/doc/en/24103. Among those 4-19 years of age who received Pandemrix -vaccine had a manifold increased risk of falling ill with narcolepsy during the 8 months following vaccination in comparison to those unvaccinated in the same age group. Based on the evaluation done so far, the National Narcolepsy Task Force finds it probable that Pandemrix -vaccination contributed to the observed increase in incidence of narcolepsy among those 4 -19 years of age. Currently, the most likely explanation is that the increase in narcolepsy is by joint effect of the vaccine and some other factor(s). At the moment, there is no evidence that the increase in narcolepsy observed in Finland could be attributed to the vaccine lots used. The results can be read in the Interim Report of the Task Force which is published on February 1st, 2011.. The association of Pandemrix-vaccination and narcolepsy was studied using ...
What is the difference between narcolepsy type 1 and type 2? Learn about the role of cataplexy and testing for hypocretin levels measured in CSF.
Narcolepsy: Find the most comprehensive real-world symptom and treatment data on narcolepsy at PatientsLikeMe. 1321 patients with narcolepsy experience fatigue, anxious mood, depressed mood, pain, and excessive daytime sleepiness (somnolence) and use Modafinil, Amphetamine-Dextroamphetamine, Armodafinil, Methylphenidate, and Lisdexamfetamine to treat their narcolepsy and its symptoms.
Adrafinil is a mild stimulant of the central nervous system commonly used to prevent sleepiness in Narcolepsy patients. Narcolepsy is characterized by excessive daytime sleepiness. Adrafinil successfully combats this, and can be used in a similar way on individuals without Narcolepsy. Adrafinil is metabolized into Modafinil while passing through the body, and essentially has the same effects; such as alertness, an increase in cognitive abilities, and an increase of energy. Adrafinil does however take longer to become active due to the time it takes the metabolite to become active in the bloodstream, which is typically 45-60 minutes.. Scientists working for Group Lafon, a French pharmaceutical company, first discovered Adrafinil in the late 1970s. The drug became available in France in 1986 as an experimental treatment for narcolepsy. The same company later made Modafinil. Adrafinil is now currently marketed as Olmifon in France and Europe.. Reactions to Adrafinil vary, though often it works very ...
I started this blog in 2008 so Id have a place to record my thoughts. I have a sleep disorder called Narcolepsy, and I also have Cataplexy. The Cataplexy causes me to become weak to the point of paralysis in response to sudden emotion, most notably laughter, being startled, sudden anger, etc. This disorder has had a great impact on my life, and this blog is about how I deal with it all. Thanks for taking the time to read, and I hope you enjoy! ~ ...
The Global Narcolepsy Therapeutics Market is expected to reach USD 3.85 billion by 2025, according to a new report by Grand View Research, Inc. The increasing awareness about this sleep disorder among public and healthcare providers is a key factor contributing to the market growth.. The Narcolepsy Network has estimated that out of every 2,000 people 1 is afflicted by this condition. Moreover, Narcolepsy UK states that around 25% patients are identified and remaining 75% are untreated as they remain undiagnosed or are misdiagnosed, which is alarming. Some organizations and networks are constantly working to spread awareness about this condition among the patients and physicians.. Full Research Report on Global Narcolepsy Therapeutics Market Analysis ...
Sleep Disorders. Narcolepsy. conventional treatment of narcolepsy include both pharmacological and non-pharmacological treatments for narcolepsy.
How to Manage Narcolepsy Symptoms. Narcolepsy is a neurological disorder characterized by a disruptive sleep pattern, lower quality of sleep, and excessive daytime sleepiness. Individuals suffering from narcolepsy may experience daytime...
The novel findings presented in this study are: 1) a population difference between patients with narcolepsy-cataplexy and age-matched controls with regard to hypoxic chemosensitivity; and 2) an association between DQB1*0602 and acute ventilatory responsiveness to progressive hypoxia. While narcolepsy-cataplexy patients do have different sleep values, AHI and lowest arterial ozygen saturation (Sa,O2) were not defining factors for the group differences in ventilatory chemosensitivity.. Contrary to results obtained in hypocretin gene knockout mice, hypercapnia responses were not affected by disease or marker state. Unlike knockout mice, where both the gene and protein are absent, in patients with narcolepsy, hypocretin-1 is often detected at some level in the CSF 9. We suspect that the effects of hypocretin on chemoresponsiveness, if present, are below a threshold for detection.. Our findings implicate DQB1*0602, or a gene located nearby, as a regulator of hypoxic responses. While DQB1*0602 is an ...
More than 1 million people in the U.S. have been diagnosed with Parkinsons disease, and approximately 20 million worldwide. (The percentage of those afflicted increases with age.)-- Narcolepsy affects approximately one in 2,000 individuals --- about 150,000 in the United States and 3 million worldwide. Its main symptoms are sleep attacks, nighttime sleeplessness and cataplexy, the sudden loss of skeletal muscle tone without loss of consciousness; that is, although the person cannot talk or move, they are otherwise in a state of high alertness, feeling, hearing and remembering everything that is going on around them.. "When we think of Parkinsons, the first thing that comes to mind are the motor disorders associated with it," said Siegel, who is also chief of neurobiology research at the Sepulveda Veterans Affairs Medical Center in Mission Hills, Calif. "But sleep disruption is a major problem in Parkinsons, often more disturbing than its motor symptoms. And most Parkinsons patients have ...
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: Narcolepsy, without cataplexy; paroxysmal sleep
Narcolepsy is also called uncontrollable daytime sleepiness. Depressed mood and Inability to concentrate these are the main Symptoms of Narcolepsy
Do you want to know more about the most effective and available medications for narcolepsy symptoms. Well, you have come to the right place. There are, in fact, a widely scattered group of medications that can be found on different online sites.
Narcolepsy may be associated with damage to the amygdala. There is hereditary cause to the occurrence of narcolepsy. Gene that causes narcolepsy has been identified.
cord have been reported (van den Pol 1999), but even if Lower CSF hypocretin levels (hypocretin-1 levels Ͻ110 spinal release occurs, the cell bodies located in the lateral pg/mL) have been shown to be diagnostic for narcolepsy hypothalamic area are likely to be active during the active period. This would not explain the discrepancy between indicate that the time of day at which sampling is done is unlikely to interfere with this test. The data should be Hypocretins are uniquely positioned for involvement in considered preliminary because of the relatively small depression. Whereas hypocretin cell bodies are all local- number of patients and the differences in times of collec- ized within the perifornical area, extremely dense, almost tion initiation between control subjects and depressed invariably excitatory projections are noted in aminergic cell groups (e.g., adrenergic locus coeruleus, serotonergic Surprisingly, the direction of the hypocretin diurnal raphe´ nuclei, histaminergic ...
http://www.reuters.com/article/2013/05/23/us-gsk-vaccine-narcolepsy-idUSBRE94M0FJ20130523 (Reuters) - GlaxoSmithKline Plcs H1N1 pandemic flu shot may put adults at higher risk of developing narcolepsy, not only children as previous studies found, Finlands National Institute for Health and Welfare said on Thursday. Growing evidence of a link between GSKs Pandemrix vaccine and an increase in narcolepsy, a rare sleep disorder, among children…
This chapter provides an overview of the epidemiology of narcolepsy. Narcolepsy is characterized by excessive sleepiness with episodic weakness often triggered by strong emotions. Due to difficulty...
A 12 year old boy who developed narcolepsy and cataplexy after being vaccinated against swine flu at age 7 has been awarded £120 000 (€165 000; $186 000) in compensation, in a ruling that opens the way for dozens of similar awards from the United Kingdoms statutory vaccine damage compensation scheme.. Claims by the unnamed boy and dozens of others who developed the chronic neurological disorders after being given the vaccine Pandemrix during the swine flu outbreak in 2009-10 had … ...
I find it frustrating to always have to be so fucking responsible for my narcolepsy. Not only does it take time and is problematic to come to terms and fully understand ones narcolepsy and health Sometimes I just push myself beyond my limits just because I want to stay out late or/and have a good…
Learn more about In his own words: living with narcolepsy at Doctors Hospital of Augusta John, 50, learned he had narcolepsy 18 years ago. The North Carolina nurses...
Learn more about In his own words: living with narcolepsy at Doctors Hospital of Augusta John, 50, learned he had narcolepsy 18 years ago. The North Carolina nurses...
Emphysema Guide to Health Wellness and Disease about Chronic Tiredness may be due to Narcolepsy a feeling of beig tired all the time health or other health and wellness medical conditions symptoms and causess
Learn more about In his own words: living with narcolepsy at Grand Strand Medical Center John, 50, learned he had narcolepsy 18 years ago. The North Carolina nurses...
Narcolepsy is a disease that causes prolongation of extreme daytime sleepiness which can leads to muscle weakness and trouble sleeping at night.
Do you fall asleep when you do NOT want to? Do you live daily with the heartbreak of Narcolepsy? Find out why it is happening to you and what you can do about it!
2 Answers - Posted in: abilify, klonopin, narcolepsy, sleep disorders, sleep - Answer: Hi Jeff, Of course it is intensified by all the meds you ...
Narcolepsy is a neurological disorder associated with the brains inability to regulate sleep-wake cycles (and the circadian rhythm). As a result, indivi
Parkinsons disease is well-known for its progression of motor disorders: stiffness, slowness, tremors, difficulties walking and talking. Less well known is that Parkinsons shares other symptoms with narcolepsy, a sleep ...
Although it had long been suspected that narcolepsy may be cased by an autoimmune disorder, this is the first study to confirm the hypothesis.
Learn more about Medications for Narcolepsy at Portsmouth Regional Hospital Main Page Risk Factors ...
Learn more about Risk Factors for Narcolepsy at Memorial Hospital Main Page Risk Factors Symptoms Diagnosis ...
The European Medicines Agency said Friday it was probing whether there is a link between the Pandemrix swine flu vaccine and the sleeping disorder narcolepsy amid concerns in Finland and Sweden.
Learn more about Talking to Your Doctor about Narcolepsy at Coliseum Health System Main Page Risk Factors ...
Hi, Im recently diagnosed with narcolepsy but have had issues with sleep my entire life. I was wondering if a certain issue i have is related to narcolepsy...
According to a report by Pharmalive, the European Commission has approved sodium oxybate (Xyrem®) for treating narcolepsy with cataplexy in adult patients.. Narcolepsy is a disorder which typically begins with excessive daytime sleepiness during the second and third decades of life, progressing to include disturbed night-time sleep, cataplexy, sleep paralysis and hypnagogic hallucinations (hallucinations while falling asleep).. The most commonly reported adverse drug reactions with sodium oxybate are dizziness, nausea, and headache, all occurring in 10% to 20% of patients.. National Electronic Library for Medicines 13/03/2007. ...
We found no differences in mean 24-h total plasma ghrelin levels or foodinduced suppression of ghrelin concentrations between narcolepsy patients and controls, nor any influence of 5 days of sodium oxybate administration in both groups. In view of the capacity of ghrelin to stimulate growth hormone secretion, it is worth noting that a report from this same research protocol showed no differences in mean hourly GH levels between patients and controls, supporting our conclusion that total ghrelin levels are not altered with hypocretin deficiency.37. Despite the excitatory influence of ghrelin on hypocretin neurons and the interaction of the ghrelin-hypocretin systems to influence food reinforcement, our finding did not show the total ghrelin level to be influenced by hypocretin deficiency, suggesting a unidirectional relationship. These findings also suggest that disturbed ingestive behavior is unlikely mediated by an altered total ghrelin level in narcolepsy patients. Notably, we measured total ...
Eighteen patients with idiopathic hypersomnia (IH) were compared with 50 patients with the narcoleptic syndrome of cataplexy and daytime sleepiness (NLS) using self report questionnaires and a diary of sleep/wake patterns. The IH group reported more consolidated nocturnal sleep, a lower propensity to nap, greater refreshment after naps, and a greater improvement in excessive daytime sleepiness since onset than the NLS group. In IH, the onset of excessive daytime sleepiness was predominantly associated with familial inheritance or a viral illness. Two variable--number of reported awakenings during nocturnal sleep and the reported change in sleepiness since onset--provided maximum discrimination between the IH and NLS groups. Confusional arousals, extended naps or nocturnal sleep, autonomic nervous system dysfunction, low ratings of medication effectiveness, or side effects of medication were not associated differentially with either IH or NLS.. ...
This ultimate guide narcolepsy treatment provigil to narcolepsy and narcolepsy treatments will give you a thorough in the treatment of narcolepsy are modafinil (Provigil) for. Your treatment. Tests. Learn about narcolepsy, a sleep disorder that causes narcolepsy treatment provigil severe daytime sleepiness. Sleepiness, behavioral problems, and weight gain may suggest the condition Find out what you can do to manage the symptoms of narcolepsy and minimise their impact on your daily life. Narcolepsy - Comprehensive overview covers symptoms, causes, treatment of overwhelming daytime sleepiness Private & confidential service. 100mg & 200mg Tablets buy provigil credit card & Pills provigil prescription australia Available. Save Up To 70% On Pills narcolepsy treatment provigil Save Up To 80% On Prescription Medicines Check Price ». Free Bonus Pills narcolepsy treatment provigil What You are Looking Best pill? Narcolepsy has provigil and memory no cure currently. Learn what you can do to overcome ...
To our knowledge, this is the first study that compares the amount of RSWA in patients with isolated loss of REM atonia (subclinical RBD) versus RBD, as well as narcolepsy and control subjects. All groups did have higher amount of submentalis EMG activity during REM sleep compared to control subjects. The study showed that RBD patients have the highest amount of submentalis muscle EMG activity in REM sleep among all studied groups. As we hypothesized, the patients with isolated loss of REM atonia demonstrated significantly lower level of submentalis muscle activity during REM sleep than those with RBD. Patients with narcolepsy could not be reliably distinguished from those two groups, but were significantly different from controls.. Patients with loss of REM atonia demonstrated higher amount of RSWA than control subjects, suggesting that despite the lack of quantitative diagnostic criteria for isolated loss of REM atonia, patients given this diagnosis were clearly different from controls. Thus, ...
Narcolepsy is characterized by the classic tetrad of excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, and sleep paralysis. Narcolepsy is thought to result from genetic predisposition, abnormal neurotransmitter functioning and sensitivity, and abnormal immune modulation.
Researchers have found good evidence that the troubling sleep disorder narcolepsy is an autoimmune disease, in which the bodys own immune system attacks healthy brain cells. A new study published in Nature Genetics links narcolepsy to mutations of two genes involved in critical roles in protecting the body from disease. These two variations, they say, are likely conspirators against [cells that produce] hypocretin, a hormone that promotes wakefulness, and that narcoleptics have been found to lack [HealthDay News].. Narcolepsy is a disruptive disorder that can trigger "sleep attacks" without any warning during any normal activity. In addition, some people can experience "cataplexy", where strong emotions such as anger, surprise, or laughter can trigger an instant loss of muscle strength, which, in some cases, can cause collapse [BBC News]. There is currently no cure for narcolepsy, although the symptoms can be largely controlled with a mix of stimulants and sleep-suppressing ...
OBJECTIVE A recent American Academy of Sleep Medicine publication identified a need for research regarding idiopathic hypersomnia. We describe various clinical and polysomnographic features of patients with idiopathic hypersomnia, with an emphasis on response to pharmacotherapy. METHODS A retrospective review of our database initially identified 997 patients, utilizing idiopathic hypersomnia, hypersomnia NOS, and primary hypersomnia as keywords. The charts of eligible patients were examined in detail, and data were abstracted and analyzed. Response to treatment was graded utilizing an internally developed scale. RESULTS Eighty-five patients were ultimately identified (65% female). Median (interquartile range) ages of onset and diagnosis were 19.6 (15.5) and 33.7 (15.5), respectively. During a median follow-up duration of 2.4 (4.7) years, 65% of patients demonstrated a complete response to pharmacotherapy as assessed by the authors grading schema. Methylphenidate was most commonly used as a
CDC Split Type: (blank) WAES0805USA06185. Write-up:Information has been received from a physician concerning an 11 year old female with penicillin allergy and no pertinent medical history who in January 2008, was vaccinated with a third dose of GARDASIL. There was no concomitant medication. In January 2"008, 2008, the patient developed cataplexy 1 to 3 days after vaccination. About 2 months later in March 2008, the patient developed narcolepsy with hallucinations and a limb movement disorder. The patient was seen in the physicians physicians office and was treated wi with an unknown stimulant. On unspecified dates the patient had a computed axial tomography, poly sleep latency tests and an magnetic resonance imaging (MRI) was ordered. At the time of reporting the patient had not recovered. The physician considered the patients cataplexy and narcolepsy with hallucinations and limb movement disorder were considered to be disabling and other medical events. Additional information has been ...
The earliest symptom of narcolepsy is daytime sleepiness. Other symptoms of narcolepsy include cataplexy, hallucinations, sleep paralysis.
There are many challenges in diagnosing and treating hypersomnias such as idiopathic hypersomnia. Here is the latest research from 2016.
TY - JOUR. T1 - Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1. AU - van Holst, Ruth Janke. AU - Janssen, Lieneke K.. AU - van Mierlo, Petra. AU - Jan Lammers, Gert. AU - Cools, Roshan. AU - Overeem, Sebastiaan. AU - Aarts, Esther. PY - 2018/12/1. Y1 - 2018/12/1. N2 - Narcolepsy type 1 is a chronic sleep disorder caused by a deficiency of the orexin (hypocretin) neuropeptides. In addition to sleep regulation, orexin is important for motivated control processes. Weight gain and obesity are common in narcolepsy. However, the neurocognitive processes associated with food-related control and overeating in narcolepsy are unknown. We explored the neural correlates of general and food-related attentional control in narcolepsy-type-1 patients (n = 23) and healthy BMI-matched controls (n = 20). We measured attentional bias to food words with a Food Stroop task and general executive control with a Classic Stroop task during fMRI. Moreover, using multiple ...
Several influenza vaccines are available on the European market, both adjuvanted and non-adjuvanted. Suspected adverse vaccine reactions (ADR) are mandated to be reported to the soon fully publicly accessible (http://www.adrreports.eu) Pan-European ADR database EudraVigilance (EV). Since public awareness of the Pandemrix-Narcolepsy signal was raised the first suspected association between a non-adjuvanted influenza vaccine and narcolepsy was reported to the EV in August 2010 from the health profession. The number has since accumulated to 18 cases by September 2012. The information quality in reported cases may vary due to the inherent character of ADR reports. Still, narcolepsy appears medically verified in 15 of the reported cases, in a majority of which an abrupt symptom development after onset of typical first symptoms (e.g. cataplexy, sleeping attacks), was reported similarly to what previously has been described for Pandemrix-related cases. Half of the cases originate from the EU area (9; 8 ...
Several influenza vaccines are available on the European market, both adjuvanted and non-adjuvanted. Suspected adverse vaccine reactions (ADR) are mandated to be reported to the soon fully publicly accessible (http://www.adrreports.eu) Pan-European ADR database EudraVigilance (EV). Since public awareness of the Pandemrix-Narcolepsy signal was raised the first suspected association between a non-adjuvanted influenza vaccine and narcolepsy was reported to the EV in August 2010 from the health profession. The number has since accumulated to 18 cases by September 2012. The information quality in reported cases may vary due to the inherent character of ADR reports. Still, narcolepsy appears medically verified in 15 of the reported cases, in a majority of which an abrupt symptom development after onset of typical first symptoms (e.g. cataplexy, sleeping attacks), was reported similarly to what previously has been described for Pandemrix-related cases. Half of the cases originate from the EU area (9; 8 ...
Idiopathic hypersomnia is a sleep disorder that causes you to be excessively sleepy during the day and to have trouble waking up from sleep.
Idiopathic hypersomnia is a sleep disorder that causes you to be excessively sleepy during the day and to have trouble waking up from sleep.
In 1966, William Dement proposed that patients with excessive daytime sleepiness, but without cataplexy, sleep paralysis, or sleep-onset rapid eye movement (REM), should not be considered narcoleptic. In 1972, Roth et al described a type of hypersomnia with sleep drunkenness that consists of difficulty coming to complete wakefulness, confusio...
Been meaning to try out a keyboard with Green Cherry Mx keyswitches. Not sure why I havent gotten a Blue Cherry Mx keyboard yet, which Ive been longing for forever….though Im currently using a Brown Cherry Mx keyboard, which seems to have helped a bit…at least in the beginning.. Being able to type is kind of important, since I work with computers. Dont know if/how to ask for help, assuming there is help…. Though back in 2000, the primary reason for wanting to have something done was that it was interfering with my photography hobby. Though the following year, it was largely forced from film to digital where image stabilization has become an essential feature in my cameras. Also wondering if my recent (last year and half) problems with vision is related or not.. Along side all this, I also have a variety of other dxs….like sleep apnea, narcolepsy with cataplexy, wed (rls), peripheral neuropathy (with pain, especially in my right leg), essential tremor (though other docs have said ...
Patients with narcolepsy may experience sleep paralysis, which is the inability to move upon awakening-or, less commonly, upon falling asleep with consciousness intact. It often is accompanied b... more
Dear DWP Adelphi Freedom-of-Information-Request,. Thank you for your response, received 16/02/2012, to my request of 19/01/2012. I note that you clearly indicate certain topics on which there is no material relevant to my request.. However, there are two areas neglected in your response, at least based on my initial scan through the material.. The section on Narcolepsy in the document containing extracts from LiMA is not, in fact, about narcolepsy. It is about sleep apnoea. It mentions narcolepsy as, effectively, a differential diagnosis for similar symptoms. Does the inclusion of this information, but no other information about narcolepsy, indicate that this is the full extent of information about narcolepsy in the areas outlined in my initial request?. In my original request, I also asked for any guidance in dealing with patients who are still seeking a diagnosis, or those who are no longer actively seeking diagnosis based on medical advise. I see that there is an entry on medically ...
ZAHN: Narcoleptics cant produce a brain chemical called Hypocretin. Normally it helps you stay awake. Without it narcoleptics constantly fall it REM, or dream sleep, but they do not fall into the deep restorative stages of sleep. If so they wake up too soon, and wake up tired. The mystery, what causes the death of these precious brain cells? And why does it often happen during adolescence? The other mystery, how to restore or replace those cells and cure narcolepsy. Fortunately, doctors have developed drugs to treat the symptoms ...
... is a chronic brain disorder characterized by poor control of sleep-wake cycles, and the individual experiences extreme daytime sleepiness and irresistible and sudden bouts of sleep strikes at any time in some cases. This is the forum for discussing anything related to this health condition
[toc]Narcolepsy is a type of sleep disorder where the person suffers from excessive sleepiness and may even fall asleep during the day. This disorder can
According to a Stanford University study, infections of the upper airway like the H1N1 virus responsible for the swine flu pandemic may trigger the onset of the sleep disorder narcolepsy.
Thus, nicorandil and no alter- ation in pregnancy causes profound change to live in provigil and high blood. A split-dose 400-mg regimen may be superior to once-daily dosing for sustaining wakefulness throughout the entire waking day. The total daily dose can be taken either as a dose in the morning or divided into two occasions, one in the morning and one in the middle of the day after the doctors assessment of the patient and the response Jan 20, 2011 · The medication should not be administered concomitantly with alcohol or any other CNS depressant due to risk of respiratory depression. Jan 01, 2005 · In the narcolepsy studies, 84% of 478 patients were titrated to a modafinil dose greater than 200 mg, with 50% at 400 mg, 34% at 300 mg, and 16% at 200 mg. Nov 18, 2019 · The Drug Modafinil and Its Benefits. Dosage. Modafinil works by stimulating the central nervous system to increase your alertness and reduce excessive sleepiness during the day. Provigil may also be used for purposes not ...
One vaccine used in Europe during the 2009 swine flu pandemic was linked to rare cases of a baffling side effect -- the sleep disorder narcolepsy. Now new research offers a clue to what happened.
Finnish and international researchers recently found a conclusive link between the Pandemrix swine flu vaccine and new cases of narcolepsy, AFP reports.
Diagnosing a not so common disorder, that too neurological is quite tricky. The greatest difficulty is separating it from the normal daytime and postprandial sleepiness of most people. Admit it, most of us feel like sleeping in the afternoon period after lunch, especially while reclining in the sofa, while watching television or in the theatres watching matinee shows. :p ...
Have you ever looked at your dog sleeping and envy how easily he nods off? Most people have some periodic difficulty falling asleep and staying asleep. Narcolepsy represents a disorder that produces just the opposite condition. And it affects dogs as well as humans! Learn what causes narcolepsy in dogs and what treatments are available ...
We are like sailors who on the open sea must reconstruct their ship but are never able to start afresh from the bottom. Where a beam is taken away a new one must at once be put there, and for this the rest of the ship is used as support. In this way, by using the old beams and driftwood the ship can be shaped entirely anew, but only by gradual reconstruction ...
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Provigil Reviews of Long-Term Use are typically 100% positive, as the eugeroic drug is very safe to take on a regular basis. Provigil, the narcolepsy
Posted on: 16th June 2016. In a judgment delivered today at the Royal Courts of Justice, Mr Justice Collins has overturned NHS Englands decision to refuse funding for a drug, Sodium Oxybate (brand name Xyrem), used to treat narcolepsy.. The Claimant, S, is a 17 year old woman with narcolepsy and cataplexy, a serious condition causing disruption to night-time sleep, excessive daytime sleepiness, hallucinations and cataplexy.. The judge recognised the clear evidence that the young woman was suffering from a particularly rare form of her condition. He was satisfied that the claimants position was exceptional and at the conclusion of the hearing made an interim order that NHS England should fund the provision of the much needed drug for a three month trial.. The judge went on to recognise that anyone reading the circumstances of this case would be surprised that sodium oxybate is not available for children generally.. In conclusion, the judge added his hope that this particular problem and ...
This occurs occasionally in around 50% of normal subjects and frequently in around 6%, usually in adolescents and the elderly, especially with REM sleep rebound following sleep deprivation and jet lag following east-west travel which induces sleep-onset REM sleep. There is also a familial tendency to sleep paralysis.. Table 6.9 Differential diagnosis of cataplexy.. Sleep attack. Epilepsy, especially gelastic and atonic. Vertebro-basilar insufficiency. Cardiac dysrhythmias. Drop attacks. Myasthenia gravis. Periodic paralysis. Faints. Gelastic syncope Hysteria. Table 6.10 Differential diagnosis of vivid dreams in narcolepsy.. Sleep paralysis should be distinguished from the generalized fatigue on waking which is common in the chronic fatigue syndrome and depression and is due to a lack of motivation rather than true paralysis. This lasts longer than sleep paralysis and small movements, for instance of the fingers, are possible. Sleep paralysis may also be confused with atonic seizures, transient ...
Narcolepsy is associated with five classical symptoms which are excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, sleep paralysis, and disrupted night sleep. The symptoms often begin either during mid-teens or mid-thirties.. Excessive daytime sleepiness means that the affected individual is unable to stay alert during waking hours and experiences general fatigue, lack of energy, and drowsiness. Excessive daytime sleepiness occurs despite prolonged night-time sleep. It is often experienced with sleep attacks which are episodes of overwhelming and strong sleepiness that often cant be overcome, causing the individual to fall asleep for a short period of time. These sleep attacks are recurrent and last less than ten minutes and may occur at any time, regardless of the situation. They may occur as the individual is watching television, walking, or even driving. Individuals affected by narcolepsy often feel significantly more alert right after a short nap.. Excessive daytime ...
As I reached the numbers around 75, I felt a wierd sensation stream over me. I felt like I was in a state between far far away, and still in my bedroom. Ive never felt such a feeling before going to sleep. Suddenly, my eyes started to flick rapidly. They started to kind-of shake violently. Some of my muscle groups of my whole body started to jolt as well. I felt as if my bed was shaking, and I heard some odd sounds in the meanwhile. Due to my extremely racing hardbeat, and the adrenaline rushing through my body, I eventually moved my feet and woke myself up. The hypnagogic hallucinations faded in almost an instant. From there, I was unable to do such trick again. I did also see formations of colors on my eyelids, and tried to create a dreamscape ...
Handling sleep paralysis is important to be able to be okay with it. Understand and get more information on the condition for this will help you solve half of the problem. Learning what lifestyles might provoke your sleep paralysis and its onset will help you handle it better.. In case it occurs be calm and doesnt panic since in most cases the brain is awake try and think of something different to distract you. For instance, sing a song in your head, wiggle your toes, distract with anything else and the episode will just end quicker. Practicing meditation helps a lot to train your mind to focus on which most people these days have lost touch with. This will help you during your distraction phase to breaking free of sleep paralysis.. To prevent the occurrences of sleep paralysis. First of all, find different ways to boost a good nights sleep. this can be from the foods you eat, regularly followed sleep routines, exercises. Also reduce bad sleep habits for like, consumption of caffeine and ...
The first time I encountered sleep paralysis was terrifying- I couldnt move my body or wake myself up. This was especially scary due to its effect on both my mind and body. Ryans eBook is the best resource for sleep paralysis sufferers I have found. Ryan reveals the main triggers of SP, and tactics for coping with it. The triggers were surprising- I didnt realize that stress, jet lag and diet could be triggers/causes of sleep paralysis. I have tested several of the tactics for coping with sleep paralysis in the eBook, and they work.. I found that Sleep Paralysis: A Dreamers Guide is written and organized in a way that is very accessible and easy to read. Additionally, each chapter of eBook is very well-written and detailed. Ryan provides many examples of his own experiences with SP. He also pulls together the latest sleep and dream research on SP, adding his own voice and insights. And best of all, the included worksheet helps the reader develop their own action plan for coping with sleep ...
TY - JOUR. T1 - Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease. T2 - A population-based study. AU - Boot, Brendon P.. AU - Boeve, Bradley F. AU - Roberts, Rosebud O. AU - Ferman, Tanis Jill. AU - Geda, Yonas Endale. AU - Pankratz, V. Shane. AU - Ivnik, Robert J.. AU - Smith, Glenn E.. AU - McDade, Eric. AU - Christianson, Teresa J H. AU - Knopman, David S. AU - Tangalos, Eric George. AU - Silber, Michael H.. AU - Petersen, Ronald Carl. PY - 2012/1. Y1 - 2012/1. N2 - Objective: Rapid eye movement sleep behavior disorder (RBD) is associated with neurodegenerative disease and particularly with the synucleinopathies. Convenience samples involving subjects with idiopathic RBD have suggested an increased risk of incident mild cognitive impairment (MCI), dementia (usually dementia with Lewy bodies), and Parkinson disease (PD). There are no data on such risks in a population-based sample. Methods: Cognitively normal subjects aged 70 ...
Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia) that involves abnormal behavior during the sleep phase with rapid eye movement (REM) sleep. It was first described in 1986. The major and arguably only abnormal feature of RBD is loss of muscle atonia (i.e., the loss of paralysis) during otherwise intact REM sleep (during which paralysis is not only normal but necessary). REM sleep is the stage of sleep in which most vivid dreaming occurs. The loss of motor inhibition leads to a wide spectrum of behavioral release during sleep. This extends from simple limb twitches to more complex integrated movement, in which people appear to be unconsciously acting out their dreams. These behaviors can be violent in nature and in some cases will result in injury to either the patient or their bed partner. RBD is characterized by the dreamer acting out his or her dreams. These dreams often involve kicking, screaming, punching, grabbing, and even jumping out of ...
Contact a Sleep Apnea Specialist in Eagleville, TN to get more information on sleep apnea, sleep disorders, sleep deprivation, insomnia treatment, snoring remedies, sleep paralysis, narcolepsy and restless legs syndrome (rls)
A Swedish study shows that patients suffering from the rapid eye movement sleep behaviour disorder (RBD) have a risk of developing Parkinsons disease or dementia, because they already suffer from a lack of dopamine in the brain.. Researchers from Aarhus University have discovered that patients with the RBD sleep behaviour disorder lack dopamine and have a form of inflammation of the brain. This means that they are at risk of developing Parkinsons disease or dementia when they grow older.. Do you sleep restlessly and hit out and kick in your sleep? This could be a sign of a disorder associated with diseases of the brain. Researchers from Aarhus University have studied the condition of the dopamine producing nerve cells in the brain and cells that participate in the brains immune system in people suffering from the rapid eye movement sleep behaviour disorder (RBD).. The study shows that patients suffering from RBD have a risk of developing Parkinsons disease or dementia in the future, because ...

A Review of the Beneficial and Harmful Effects of Laughter « Chiropractic Resource Organization - largest Chiropractic News...A Review of the Beneficial and Harmful Effects of Laughter « Chiropractic Resource Organization - largest Chiropractic News...

Cataplexy, often allied to narcolepsy (Gélineaus syndrome), [56] is characterised by sudden loss of muscle tone provoked by ... 60] In one case, cataplexy induced by laughter affected only the right side of the body; [61] this patient presumably could ... Validation of a cataplexy questionnaire in 983 sleep-disorders patients.. Sleep 999;22:77-87. ... Unilateral cataplexy associated with systemic lupus erythematosus.. J Neurol Neurosurg Psychiatry1976;39:1023-6. ...
more infohttp://chiro.org/wordpress/2013/12/a-review-of-the-beneficial-and-harmful-effects-of-laughter/

Periodic Limb Movement Disorder - Causes, Symptoms, Diagnosis, Treatment and PrognosisPeriodic Limb Movement Disorder - Causes, Symptoms, Diagnosis, Treatment and Prognosis

Cataplexy. *Heart diseases. *Mental disorders. *Obstructive sleep apnea. *Musculoskeletal diseases. *Physical activities or ...
more infohttps://www.primehealthchannel.com/periodic-limb-movement-disorder.html

Laughter Is OK Medicine, Unless It Kills You - InkfishLaughter Is OK Medicine, Unless It Kills You - Inkfish

People with cataplexy, a rare condition tied to narcolepsy, may suddenly lose all their muscle strength and collapse during a ...
more infohttp://blogs.discovermagazine.com/inkfish/2013/12/14/laughter-is-ok-medicine-unless-it-kills-you/

Sleep paralysis - Sleep Medicine - Euroform HealthcareSleep paralysis - Sleep Medicine - Euroform Healthcare

Table 6.9 Differential diagnosis of cataplexy.. Sleep attack. Epilepsy, especially gelastic and atonic ...
more infohttps://www.euroformhealthcare.biz/sleep-medicine/sleep-paralysis.html

December 14, 2013 - Chiropractic Resource Organization - largest Chiropractic News SourceDecember 14, 2013 - Chiropractic Resource Organization - largest Chiropractic News Source

... cataplexy, headaches, jaw dislocation, and stress incontinence (from laughing like a drain). Infectious laughter can ...
more infohttp://chiro.org/wordpress/2013/12/14/

Laughter is no joke - Can laughter kill you? Pathological Laughter - Dr 
Sampurna Roy MDLaughter is no joke - Can laughter kill you? Pathological Laughter - Dr Sampurna Roy MD

Cataplexy, is characterised by sudden loss of muscle tone provoked by laughter and other stimuli. ...
more infohttp://www.pathopedia-india.com/pathological_laughter.htm

Living With Narcolepsy and CataplexyLiving With Narcolepsy and Cataplexy

... loss of muscle control and hallucinations are everyday occurrences for people with narcolepsy and cataplexy. ... loss of muscle control and hallucinations are everyday occurrences for people with narcolepsy and cataplexy. ... Managing Narcolepsy and Cataplexy Naturally. In some cases, lifestyle interventions can help to manage the symptoms of ... With conditions as complex as narcolepsy and cataplexy, its strongly recommended that you seek out an expert in this area who ...
more infohttps://articles.mercola.com/sites/articles/archive/2017/11/09/living-with-narcolepsy-cataplexy.aspx

Cataplexy - ScholarpediaCataplexy - Scholarpedia

Cataplexy is the sudden loss of muscle tone that is triggered by the experience of an intense emotion. The word cataplexy comes ... Cataplexy in humans is most commonly related to a lesion of the hypocretin system. In a dog model cataplexy is caused by a ... Secondary cataplexy Despite its primary association with narcolepsy, cataplexy is considered secondary when it is due to ... Cataplexy is commonly associated with narcolepsy. Primary cataplexy is a life long condition and can be disabling for the ...
more infohttp://www.scholarpedia.org/article/Cataplexy

Cataplexy - WikipediaCataplexy - Wikipedia

Cataplexy without narcolepsy is rare and the cause is unknown. The term cataplexy originates from the Greek κατά (kata, meaning ... Secondary cataplexy is associated with specific lesions located primarily in the lateral and posterior hypothalamus. Cataplexy ... "Causes of Cataplexy". Demand Media, Inc. Retrieved April 30, 2012. ASA. "About Narcolepsy / Cataplexy". Retrieved July 26, 2016 ... Cataplexy is considered secondary when it is due to specific lesions in the brain that cause a depletion of the hypocretin ...
more infohttps://en.wikipedia.org/wiki/Cataplexy

Narcolepsy and Cataplexy in Dogs - PetPlaceNarcolepsy and Cataplexy in Dogs - PetPlace

Narcolepsy and Cataplexy in Dogs. 15 Sep, 2015 Dr. John McDonnell 68,573 Views ... Cataplexy is characterized by brief episodes of muscle paralysis with loss of tendon reflexes; the dog stays alert and will ... Treatment of Narcolepsy and Cataplexy in Dogs. * Primary goal is to reduce the severity and frequency of narcoleptic- ... Overview of Canine Narcolepsy and Cataplexy Narcolepsy is excessive daytime sleepiness, lethargy, or brief periods of collapse ...
more infohttps://www.petplace.com/article/dogs/pet-health/narcolepsy-and-cataplexy-in-dogs/

Cataplexy | Narcolepsy UKCataplexy | Narcolepsy UK

Does everyone with narcolepsy have cataplexy?. It is thought that about 75% of patients with narcolepsy experience cataplexy. ... When cataplexy is present, it is extremely rare for it to be an isolated symptom - the vast majority of those with typical ... Cataplexy attacks generally last less than two minutes, and they may only last a few seconds, though some people have repeated ... Cataplexy may be most severe when the person with narcolepsy is tired rather than fully alert, and can lead to considerable ...
more infohttps://www.narcolepsy.org.uk/resources/cataplexy

Cataplexy: Narcoleptic Paralysis - Depression AllianceCataplexy: Narcoleptic Paralysis - Depression Alliance

Cataplexy is a rare disorder in which a person loses muscle control when experiencing strong emotions. Find out about causes, ... Cataplexy and Other Conditions. Cataplexy vs Narcolepsy. Cataplexy is most often seen in patients who are diagnosed with ... Cataplexy: What Does It Mean?. Cataplexy is a partial or generalized loss of muscle tone or control that is triggered by ... Possible Medications for Cataplexy. Sodium oxybate is a medication approved by the FDA for use in cataplexy. It is thought to ...
more infohttps://www.depressionalliance.org/cataplexy/

What is Narcolepsy? Symptoms, Treatment, Cataplexy, Causes & DrugsWhat is Narcolepsy? Symptoms, Treatment, Cataplexy, Causes & Drugs

Narcolepsy is a neurological order with symptoms like cataplexy (a debilitating condition in which a person collapses after ... Cataplexy is a sudden, temporary loss of muscle control in a person with narcolepsy. An attack of cataplexy usually is ... Medications for cataplexy. Anticataplectic medication is the general name for drugs that are used to treat cataplexy. These ... The onset of cataplexy may coincide with the onset of excessive daytime sleepiness, but cataplexy often develops years later, ...
more infohttps://www.rxlist.com/narcolepsy/article.htm

Why couldnt I move? - paralysis epilepsy cataplexy | Ask MetaFilterWhy couldn't I move? - paralysis epilepsy cataplexy | Ask MetaFilter

Heres a description of cataplexy from wikipedia. posted by trunk muffins at 5:20 PM on June 22, 2010 [2 favorites] ... and my insurance wont pay for the sleep study necessary to diagnose narcolepsy/cataplexy, so my journey to a diagnosis is not ...
more infohttps://ask.metafilter.com/157498/Why-couldnt-I-move

Cataplexy | definition of cataplexy by Medical dictionaryCataplexy | definition of cataplexy by Medical dictionary

... cataplexy explanation free. What is cataplexy? Meaning of cataplexy medical term. What does cataplexy mean? ... Looking for online definition of cataplexy in the Medical Dictionary? ... cataplexy. (kăt′ə-plĕk′sē). n. pl. cataplex·ies A sudden loss of muscle tone and strength, usually caused by an extreme ... cataplexy. Also found in: Dictionary, Encyclopedia, Wikipedia. cataplexy. [kat´ah-plek″se] a condition, often associated with ...
more infohttps://medical-dictionary.thefreedictionary.com/cataplexy

Medicine for cataplexy - Answers on HealthTapMedicine for cataplexy - Answers on HealthTap

Ali on medicine for cataplexy: If the medicine gave you the best results discuss with your prescribing physician the dose ... Can you tell me what to expect with symptoms of cataplexy when I am very scaredwith the possibility of it being cataplexy? ... It looks like cataplexy, but i dont have other narcolepsy symptoms. Can it be cataplexy without n.? ... Cataplexy attacks: Cataplexy attacks = sudden onset but brief bouts of marked muscle weakness which can cause someone to ...
more infohttps://www.healthtap.com/topics/medicine-for-cataplexy

Kunena :: Topic: Cataplexy metabolism, forming primary, reflexes, operation. (1/1)Kunena :: Topic: Cataplexy metabolism, forming primary, reflexes, operation. (1/1)

TOPIC: Cataplexy metabolism, forming primary, reflexes, operation. Cataplexy metabolism, forming primary, reflexes, operation. ...
more infohttp://www.cma2000srl.com/index.php/forum/welcome-mat/500-cataplexy-metabolism-forming-primary-reflexes-operation

Get PDF - Role of the medial prefrontal cortex in cataplexyGet PDF - Role of the medial prefrontal cortex in cataplexy

Role of the medial prefrontal cortex in cataplexy ... Narcolepsy with cataplexy is caused by a loss of orexin (also ... Role of the medial prefrontal cortex in cataplexy. Role of the medial prefrontal cortex in cataplexy. Oishi, Y.; Williams, R.H ... These observations indicate that the mPFC is a critical site through which positive emotions trigger cataplexy. (PDF emailed ... Narcolepsy is characterized by chronic sleepiness and cataplexy, episodes of profound muscle weakness that are often triggered ...
more infohttps://eurekamag.com/research/055/614/055614055.php

Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status | European Respiratory...Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status | European Respiratory...

Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status. F. Han, E. Mignot, Y.C. Wei ... Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status. F. Han, E. Mignot, Y.C. Wei ... Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status. F. Han, E. Mignot, Y.C. Wei ... While narcolepsy-cataplexy patients do have different sleep values, AHI and lowest arterial ozygen saturation (Sa,O2) were not ...
more infohttp://erj.ersjournals.com/content/36/3/577

Narcolepsy with cataplexy Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comNarcolepsy with cataplexy Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com

Narcolepsy with cataplexy information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, ... Narcolepsy with cataplexy *What is Narcolepsy with cataplexy? *Videos related to Narcolepsy with cataplexy *Causes of ... Narcolepsy with cataplexy: Introduction. Narcolepsy with cataplexy: Narcolepsy refers to excessive sleepiness and cataplexy ... Diagnostic Tests for Narcolepsy with cataplexy *Home Testing and Narcolepsy with cataplexy *Signs of Narcolepsy with cataplexy ...
more infohttps://www.rightdiagnosis.com/n/narcolepsy_with_cataplexy/intro.htm

Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy | Clinical Research Trial Listing (...Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy | Clinical Research Trial Listing (...

Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy ... Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy Brief description of study. The ... this study is to determine whether FT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy ...
more infohttps://www.centerwatch.com/clinical-trials/listings/90063/excessive-daytime-sleepiness-sodium-oxybate-treatment-excessive/?geo_lat=49.8879519&geo_lng=-119.4960106&radius=10&featured=true

Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP) - Full Text View -...Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP) - Full Text View -...

... and cataplexy (minimum of 3 complete or partial cataplexy attacks per week). ... Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP). The safety and ... Narcolepsy With Cataplexy Excessive Daytime Sleepiness Drug: Pitolisant Drug: Placebo Phase 3 ... Cataplexy. Disorders of Excessive Somnolence. Sleep Disorders, Intrinsic. Dyssomnias. Sleep Wake Disorders. Nervous System ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01800045?cond=%22narcolepsy%22&rank=47

Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder -...Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder -...

Narcolepsy Cataplexy Other: fMRI Other: Videopolysomnography Other: NC (narcolepsy-cataplexy) Not Applicable ... Other: NC (narcolepsy-cataplexy) The investigators hypothesize that NC patients with RBD have a more severe dysfunction of the ... Cataplexy. Disorders of Excessive Somnolence. Sleep Disorders, Intrinsic. Dyssomnias. Sleep Wake Disorders. Nervous System ... Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder (NC ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03425214?recrs=abc&cond=%22Narcolepsy%22&rank=16

Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience  - Zurich Open Repository and ArchiveSodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience - Zurich Open Repository and Archive

In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18/18 DQB1*0602 ... In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18/18 DQB1*0602 ... Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy. ... Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy. ...
more infohttps://www.zora.uzh.ch/id/eprint/50908/
  • Cataplexy due to brainstem lesions is uncommon particularly when seen in isolation. (wikipedia.org)
  • In addition, neurons in the mPFC innervated parts of the amygdala and lateral hypothalamus that contain neurons active during cataplexy and that innervate brainstem regions known to regulate motor tone. (eurekamag.com)
  • Cataplexy may rapidly reoccur repeatedly, giving birth to "status cataplecticus" , and to the "limp man syndrome" as described by Stalh et al . (scholarpedia.org)
  • Narcolepsy-cataplexy syndrome associated with DRB1*0806-DQB*0602 haplotype in a Caucasian patient. (semanticscholar.org)
  • The National Niemann-Pick Disease Foundation notes that cataplexy itself is not a serious medical emergency, but because a cataplectic person may suddenly collapse (due to the rapid loss of muscle control), there "can be a anger if the person strikes his head while collapsing or lands awkwardly. (universityhealthnews.com)
  • In cataplexy, you suddenly lose the strength and control in some of your muscles whilst you are awake. (patient.info)
  • Secondary cataplexy is associated with specific lesions located primarily in the lateral and posterior hypothalamus. (wikipedia.org)