AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHumanities
CataplexyNarcolepsyNeuropeptidesHypersomnolence, IdiopathicSleep ParalysisWit and Humor as TopicHLA-DQ beta-ChainsSleep, REMSodium OxybateIntracellular Signaling Peptides and ProteinsOrexin ReceptorsDisorders of Excessive SomnolenceSleep StagesPolysomnographyWakefulnessEmotional IntelligenceMuscle HypotoniaHLA-DQ AntigensReceptors, NeuropeptideElectroencephalographyPonsHypothalamic HormonesSleepSalicylamidesLaughterCatalepsyArousal
Cataplexy
A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)
Narcolepsy
A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
Neuropeptides
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Hypersomnolence, Idiopathic
A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)
Sleep Paralysis
A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)
Wit and Humor as Topic
The faculty of expressing the amusing, clever, or comical or the keen perception and cleverly apt expression of connections between ideas that awaken amusement and pleasure. (From Random House Unabridged Dictionary, 2d ed)
HLA-DQ beta-Chains
Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.
Sleep, REM
A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.
Sodium Oxybate
The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.
Intracellular Signaling Peptides and Proteins
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Orexin Receptors
G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.
Disorders of Excessive Somnolence
Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
Sleep Stages
Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.
Polysomnography
Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.
Wakefulness
A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.
Emotional Intelligence
The ability to understand and manage emotions and to use emotional knowledge to enhance thought and deal effectively with tasks. Components of emotional intelligence include empathy, self-motivation, self-awareness, self-regulation, and social skill. Emotional intelligence is a measurement of one's ability to socialize or relate to others.
Muscle Hypotonia
A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.
HLA-DQ Antigens
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Receptors, Neuropeptide
Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system.
Electroencephalography
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Pons
The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.
Hypothalamic Hormones
Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.
Sleep
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
Salicylamides
Amides of salicylic acid.
Laughter
An involuntary expression of merriment and pleasure; it includes the patterned motor responses as well as the inarticulate vocalization.
Catalepsy
A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.
Arousal
Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.

Unilateral cataplexy associated with systemic lupus erythematosus. (1/120)

A patient with systemic lupus erythematosus (SLE) developed attacks of unilateral cataplexy precipitated by laughter. Unilateral cataplexy has not been described previously in detail and its association with SLE is unique. The clinical details, investigations, and diagnostic criteria are discussed and a causal relationship between cataplexy and SLE is suggested.  (+info)

Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy. (2/120)

Cataplexy, an abnormal manifestation of REM sleep atonia, is currently treated with antidepressants. These medications also reduce physiological REM sleep and induce nocturnal sleep disturbances. Because a recent work on canine narcolepsy suggests that the mechanisms for triggering cataplexy are different from those for REM sleep, we hypothesized that compounds which act specifically on cataplexy, but not on REM sleep, could be developed. Canine studies also suggest that the dopamine D2/D3 receptor mechanism is specifically involved in the regulation of cataplexy, but little evidence suggests that this mechanism is important for REM sleep regulation. We therefore assessed the effects of sulpiride, a commonly used D2/D3 antagonist, on cataplexy and sleep in narcoleptic canines to explore the possible clinical application of D2/D3 antagonists for the treatment of human narcolepsy. Both acute and chronic oral administration of sulpiride (300 mg/dog, 600 mg/dog) significantly reduced cataplexy without noticeable side effects. Interestingly, the anticataplectic dose of sulpiride did not significantly reduce the amount of REM sleep. Sulpiride (and other D2/D3 antagonists) may therefore be an attractive new therapeutic indication in human narcolepsy.  (+info)

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. (3/120)

Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence that additional HLA class II alleles have on susceptibility to this disease. In this work, 1,087 control subjects and 420 narcoleptic subjects with cataplexy, from three ethnic groups, were HLA typed, and the effects of HLA-DRB1, -DQA1, and -DQB1 were analyzed. As reported elsewhere, almost all narcoleptic subjects were positive for both HLA-DQA1*0102 and -DQB1*0602. A strong predisposing effect was observed in DQB1*0602 homozygotes, across all ethnic groups. Relative risks for narcolepsy were next calculated for heterozygous DQB1*0602/other HLA class II allelic combinations. Nine HLA class II alleles carried in trans with DQB1*0602 were found to influence disease predisposition. Significantly higher relative risks were observed for heterozygote combinations including DQB1*0301, DQA1*06, DRB1*04, DRB1*08, DRB1*11, and DRB1*12. Three alleles-DQB1*0601, DQB1*0501, and DQA1*01 (non-DQA1*0102)-were found to be protective. The genetic contribution of HLA-DQ to narcolepsy susceptibility was also estimated by use of lambda statistics. Results indicate that complex HLA-DR and -DQ interactions contribute to the genetic predisposition to human narcolepsy but that additional susceptibility loci are also most likely involved. Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy.  (+info)

Health-related quality of life in narcolepsy. (4/120)

Narcolepsy is a chronic sleep disorder characterised by symptoms of excessive daytime sleepiness and cataplexy. The aim of this study was to describe the health-related quality of life of people with narcolepsy residing in the UK. The study comprised a postal survey of 500 members of the UK narcolepsy patient association, which included amongst other questions the UK Short Form 36 (SF-36), the Beck Depression Inventory (BDI), and the Ullanlinna Narcolepsy Scale (UNS). A total of 305 questionnaires were included in the final analysis. The results showed that the subjects had significantly lower median scores on all eight domains of the SF-36 than normative data, and scored particularly poorly for the domains of role physical, energy/vitality, and social functioning. The BDI indicated that 56.9% of subjects had some degree of depression. In addition, many individuals described limitations on their education, home, work and social life caused by their symptoms. There was little difference between the groups receiving different types of medication. This study is the largest of its type in the UK, although the limitations of using a sample from a patient association have been recognised. The results are consistent with studies of narcolepsy in other countries in demonstrating the extensive impact of this disorder on health-related quality of life.  (+info)

Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area. (5/120)

Orexin-A (OX-A) and orexin-B (OX-B) (hypocretin 1 and hypocretin 2) are synthesized in neurons of the perifornical, dorsomedial, lateral, and posterior hypothalamus. The locus coeruleus (LC) receives the densest extrahypothalamic projections of the orexin (OX) system. Recent evidence suggests that descending projections of the LC have a facilitatory role in the regulation of muscle tone. The pontine inhibitory area (PIA), located ventral to LC, receives a moderate OX projection and participates in the suppression of muscle tone in rapid-eye-movement sleep. We have examined the role of OX-A and -B in muscle-tone control using microinjections (0.1 microM to 1 mM, 0.2 microl) into the LC and PIA in decerebrate rats. OX-A and -B microinjections into the LC produced ipsi- or bilateral hindlimb muscle-tone facilitation. The activity of LC units was correlated with the extent of hindlimb muscle-tone facilitation after OX microinjections (100 microM, 1 microl) into fourth ventricle. Microinjections of OX-A and -B into the PIA produced muscle-tone inhibition. We did not observe any significant difference in the effect of OX-A and -B on muscle tone at either site. Our data suggest that OX release activates LC units and increases noradrenergic tonus in the CNS. Moreover, OX-A and -B may also regulate the activity of pontine cholinoceptive and cholinergic neurons participating in muscle-tone suppression. Loss of OX function may therefore disturb both facilitatory and inhibitory motor processes.  (+info)

MAO-A and COMT polymorphisms and gene effects in narcolepsy. (6/120)

Narcolepsy presents one of the tightest associations with a specific HLA antigen (DQB1*0602) but there is strong evidence that non-HLA genes also confer susceptibility. Recent observations have implicated the hypocretin/orexin system in narcolepsy in both humans and animals. In addition, the implication of monoaminergic systems in the pathophysiology of narcolepsy is well established and a significant association between the monoamine oxydase-A (MAO-A) gene and human narcolepsy has recently provided a possible genetic link. We investigated polymorphisms of MAO-A and catechol-O-methyltransferase (COMT) in 97 Caucasians with well-defined narcolepsy-cataplexy and sought for genotypic effects on disease symptoms. No evidence of association between genotype or allele frequencies of both MAO-A or COMT gene and narcolepsy was found. However, a sexual dimorphism and a strong effect of COMT genotype on disease severity were found. Women narcoleptics with high COMT activity fell asleep twice as fast as those with low COMT activity during the multiple sleep latency test (MSLT) while the opposite was true for men. COMT genotype also strongly affected the presence of sleep paralysis and the number of REM sleep onsets during the MSLT. In agreement with well-documented pharmacological results in canine narcolepsy, this study reports the first genetic evidence for the critical involvement of the dopaminergic and/or noradrenergic systems in human narcolepsy.  (+info)

Childhood onset of narcolepsy-cataplexy syndrome in Turkey: clinical and genetic study. (7/120)

Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleepiness and abnormal manifestations of rapid eye movement (REM) sleep including cataplexy, sleep paralysis and hypnagogic hallucinations. It is known to be complex disorder in which both genetic predisposition and environmental factors play a role. In humans, susceptibility to narcolepsy is tightly associated with a specific HLA allele, DQB1*0602. In this report, we took advantage of the ongoing genetic study in Turkish narcoleptic patients to document clinical and genetic data of eight patients whose onset of symptoms were in the childhood period.  (+info)

Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia. (8/120)

The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy, and unusually rapid transitions to rapid eye movement sleep, opens a new field of investigation in the area of disorders of sleep and activation. Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) (also called orexin-A and orexin-B) are newly discovered neuropeptides processed from a common precursor. Hypocretin containing cells are located exclusively in the lateral hypothalamus, with widespread projections within the central nervous system. The role of the hypocretin system in other disorders causing excessive daytime sleepiness is more uncertain. This study reports the findings of a prospective study measuring cerebrospinal fluid concentrations of hypocretin-1 and hypocretin-2 in HLA DQB1*0602 positive narcolepsy with cataplexy, monosymptomatic narcolepsy, and primary hypersomnia. The results confirmed the previous observations, that hcrt-1 is deficient in narcolepsy and for the first time report very low levels of hcrt-1 in primary hypersomnia. It is also reported for the first time that there is a generalised defect in hcrt-2 transmission in all three of these clinical entities compared with controls.  (+info)

REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine...REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine...
Orexin (hypocretin)-containing neurons of the hypothalamus project to brainstem sites that are involved in the neural control of REM sleep, including the locus coeruleus, the dorsal raphe nucleus, the cholinergic zone of the mesopontine tegmentum, and the pontine reticular formation (PRF). Orexin knockout mice exhibit narcolepsy/cataplexy, and a mutant and defective gene for the orexin type II receptor is present in dogs with an inherited form of narcolepsy/cataplexy. However, the physiological systems mediating these effects have not been described. We reasoned that, since the effector neurons for the majority of REM sleep signs, including muscle atonia, were located in the PRF, this region was likely implicated in the production of these orexin-related abnormalities. To test this possibility, we used microdialysis perfusion of orexin type II receptor antisense in the PRF of rats. Ten to 24 hours after antisense perfusion, REM sleep increased two- to three-fold during both the light period ...
https://read.qxmd.com/read/11382892/rem-sleep-enhancement-and-behavioral-cataplexy-following-orexin-hypocretin-ii-receptor-antisense-perfusion-in-the-pontine-reticular-formation
Unilateral cataplexy associated with systemic lupus erythematosus | Journal of Neurology, Neurosurgery & PsychiatryUnilateral cataplexy associated with systemic lupus erythematosus | Journal of Neurology, Neurosurgery & Psychiatry
A patient with systemic lupus erythematosus (SLE) developed attacks of unilateral cataplexy precipitated by laughter. Unilateral cataplexy has not been described previously in detail and its association with SLE is unique. The clinical details, investigations, and diagnostic criteria are discussed and a causal relationship between cataplexy and SLE is suggested.. ...
https://jnnp.bmj.com/content/39/10/1023
Tags: advocacy - APNARCOPLEXIC
Cataplexy is estimated to be present in ~70% of Narcolepsy cases, but I had heard that the severe form affects less than 10-15%. It is said that Narcolepsy with Cataplexy, affects about one in every 3,000 Americans. More cases without Cataplexy are likely to exist.. In the research for this post, I came across Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy with Cataplexy, where the thresholds are revealed to be from statistical analysis, using R. Where the optimal cutoff for CSF Hypocretin-1, the ROC curve analysis defines a gold standard of approximately 200 pg/mL as the cutoff for the diagnosis of Narcolepsy without Cataplexy vs those with, and is convenient with previously defined cut offs of low (,=110), intermediate (,=200), or normal (>200), where Narcolepsy with Cataplexy are those with 110 pg/ml or less. Intermediate….do we really exist? From what I recall reading (while I was required to lay as still as possible on back follow the spinal tap), those values were again ...
http://apnarcoplexic.com/advocacy:
Is a purpose of REM sleep atonia to help regenerate intervertebral disc volumetric loss? | Journal of Circadian Rhythms | Full...Is a purpose of REM sleep atonia to help regenerate intervertebral disc volumetric loss? | Journal of Circadian Rhythms | Full...
Approximately twenty-five percent of sleep is REM in the young adult [13] but interestingly, this varies with age [14]. We know that infants have much more REM compared to adults, as human infants typically enter REM sleep directly after the initial onset of sleep and spend approximately 50% of their total sleep time in REM [15]. And we also know that as we age, cartilaginous structures desiccate [16]. During development, infants have much more cartilaginous tissue compared to adults while they undergo the metabolic demanding task of endochondral ossification. Chondrocytes constitute the predominant cell of cartilage which is an interface tissue that is avascular, aneural and alymphatic [17]. These cells lay in an environment that is influenced by mechanical forces [18] whereby cellular perception of mechanical stress within cartilaginous tissues is an important modulator of chondrocyte function [19]. Recent understandings of growth plate proliferation have revealed that distraction is ...
https://jcircadianrhythms.biomedcentral.com/articles/10.1186/1740-3391-7-1
Get PDF - Role of the medial prefrontal cortex in cataplexyGet PDF - Role of the medial prefrontal cortex in cataplexy
Oishi, Y.; Williams, R.H.; Agostinelli, L.; Arrigoni, E.; Fuller, P.M.; Mochizuki, T.; Saper, C.B.; Scammell, T.E., 2013: Role of the medial prefrontal cortex in cataplexy
https://eurekamag.com/research/055/614/055614055.php
Why couldnt I move? - paralysis epilepsy cataplexy | Ask MetaFilterWhy couldnt I move? - paralysis epilepsy cataplexy | Ask MetaFilter
Trust me, I know it seems weird. I fainted in the shower on Sunday and felt fine Monday but when I called to make an appointment just to get it checked out they asked that I go to the ER, so I did. I was reluctant because it didnt seem like a huge deal -- it was probably just hypotension from the heat -- but everyone else waiting at the ER was also there for something that wasnt obviously immediately killing them. You dont mess around with neurological things, fainting, etc, for good reason. If it was a stroke, which is possible, you need to go get it checked out ASAP. If it wasnt a stroke, you still need to know what it was. No ones going to get angry at you for showing up if it doesnt end up being serious ...
https://ask.metafilter.com/157498/Why-couldnt-I-move
2nd seizure and feeling very scared - Epilepsy - MedHelp2nd seizure and feeling very scared - Epilepsy - MedHelp
I am 34 and was dxd with Narcolepsy/Cataplexy last year after searching for answers for a very long time. I have white matter and grey matter spots/lesions that are unenhanced with contrast (demyelin...
https://www.medhelp.org/posts/Epilepsy/2nd-seizure-and-feeling-very-scared/show/759550
The secondary narcolepsycataplexy - Sleep DisordersThe secondary narcolepsycataplexy - Sleep Disorders
Association of cataplexy with EDS with another disorder of the brain was first reported in the early 1900. These associations includes tumors, localized most
https://www.mussenhealth.us/sleep-disorders/the-secondary-narcolepsycataplexy.html
Hypersomnia and depressive symptoms: methodological and clinical aspects | BMC Medicine | Full TextHypersomnia and depressive symptoms: methodological and clinical aspects | BMC Medicine | Full Text
Narcolepsy is an orphan sleep disorder (0.026% of the general population) characterized by a clinical history of EDS and abnormal manifestations of dissociated REM sleep, such as cataplexy (that is, sudden loss of muscle tone triggered by strong emotions), hypnagogic hallucinations, and sleep paralysis [59]. Narcolepsy typically starts during adolescence, a critical period of normal development and interpersonal relationship building [60]. Cataplexy is the best clinical diagnostic marker for the disease, occurring in 70% to 80% of patients. Two separate entities are individualized: narcolepsy with and without cataplexy [11]. Narcolepsy diagnosis requires nocturnal PSG recording followed by the MSLT, the latter showing a mean sleep latency ,8 minutes and two or more sleep onset REM periods (SOREMPs).. For 120 years after it was identified, narcolepsy was attributed to psychiatric etiologies [61]. In the 2000s, however, it was determined that when cataplexy is present, narcolepsy is almost always ...
https://0-bmcmedicine-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1741-7015-11-78
Cerebrospinal fluid hypocretin levels are normal in idiopathic REM sleep behaviour disorder. - MRC Weatherall Institute of...
BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a common sleep disorder that can be associated with a number of neurodegenerative conditions as well as with narcolepsy. Current diagnostic criteria require overnight polysomnography, and there are no other biomarkers available. The control of REM sleep is complex with a putative on/off switch within the brainstem activated, amongst other things, by hypocretinergic pathways from the lateral hypothalamus. METHODS: Cerebrospinal fluid hypocretin levels were measured in five patients with idiopathic RBD. RESULTS: Hypocretin levels were between 254 and 450 pg/ml and therefore within the normal range of |100 pg/ml. CONCLUSION: Hypocretin levels in patients with idiopathic RBD are normal.
https://www.imm.ox.ac.uk/publications/346247
Narcolepsy - Start SleepingNarcolepsy - Start Sleeping
There are two kinds of narcolepsy: one with cataplexy, and the other without. Cataplexy is a sudden loss of muscle control when the person can fall or slur their words and is often caused by an emotion such as laughter or some kind of excitement. During cataplexy, the person is awake.. Narcolepsy without cataplexy is often less severe than with cataplexy, and its a sleep disorder that can cause the sudden onset of sleep, sleep paralysis, hallucinations, and excessive sleepiness. It affects around 1 in 2,000 people. People with narcolepsy can be very tired during the day, and have vivid hallucinations and sleep paralysis while falling asleep and waking up. They also have disturbed sleep at night because the brain doesnt go through the normal flow through the different phases of sleep-people with narcolepsy can go directly from waking to REM (rapid eye movement) sleep, bypassing light sleep and deep sleep. ...
https://startsleeping.org/sleep-disorders/narcolepsy/
Narcolepsy and Cataplexy Symptoms and Treatments in Dogs | Pet Health at Wiki-pet.com
Narcolepsy and Cataplexy Symptoms and Treatments in Dogs - Narcolepsy and cataplexy are uncommon disorders of the sleep mechanism in which a dog is excessively sleepy all day (narcolepsy) or experiences sudden muscle paralysis and collapse (cataplecy). Between attacks the dog is completely normal.
http://www.wiki-pet.com/health/dog/condition/index.php?condition_id=275&name=narcolepsy+and+cataplexy
DSpace at EWHA: 탈력발작을 동반하는 기면증 환자의 국소 뇌혈류에 관한 연구DSpace at EWHA: 탈력발작을 동반하는 기면증 환자의 국소 뇌혈류에 관한 연구
To investigate the abnormality of cerebral perfusion in narcoleptics with cataplexy, cerebral perfusion was measured by brain single photon emission computed tomography(SPECT). The difference of cerebral perfusion between narcoleptics and normal controls was tested by statistical parametric mapping(SPM) analysis. Twenty-five narcoleptics with cataplexy and 25 normal controls performed 99mTc-ethylcysteinate dimer brain SPECT study. A night polysomnography and multiple sleep latency test (MSLT) in next day were performed in all patients. Brain SPECT was carried out in all patients and normal controls during waking state. The clinical symptoms and the results of MSLT were concordant to the International Classification of Sleep Disorders criteria for narcolepsy in all patients. The MSLT showed short mean sleep latency(1.69±1.0 min) and 2 - 5 sleep onset REM periods per each patient. The SPM analysis of brain SPECT in narcoleptics with cataplexy showed hypoperfusion in bilateral anterior ...
http://dspace.ewha.ac.kr/handle/2015.oak/186890
Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without...Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without...
Sigma-Aldrich offers abstracts and full-text articles by [Akiko Ozaki, Yuichi Inoue, Kenichi Hayashida, Toru Nakajima, Makoto Honda, Akira Usui, Yoko Komada, Mina Kobayashi, Kiyohisa Takahashi].
https://www.sigmaaldrich.com/catalog/papers/22137109
What is Narcolepsy? Symptoms, Treatment, Cataplexy, Causes & DrugsWhat is Narcolepsy? Symptoms, Treatment, Cataplexy, Causes & Drugs
Narcolepsy is a neurological order with symptoms like cataplexy (a debilitating condition in which a person collapses after strong emotions) and hallucinations. Treatment depends upon the severity of the symptoms of narcolepsy, but usually it is treated with drugs. The causes of narcolepsy are not clearly understood.
https://www.rxlist.com/narcolepsy/article.htm
17 year old woman with narcolepsy refused medication funding by NHS England17 year old woman with narcolepsy refused medication funding by NHS England
Posted on: 26th April 2016. On Wednesday 4th May 2016, the High Court will consider an application by the father of a child for judicial review of a decision by NHS England to refuse funding for a drug Sodium Oxybate (brand name Xyrem®) used to treat narcolepsy. The Court will be asked to intervene to require NHS England to fund the only treatment which has a real prospect of reducing the symptoms of this devastating illness.. The Claimant, X, is a 17 year old woman who has narcolepsy and cataplexy, a serious neurological condition causing disruption to night-time sleep, excessive daytime sleepiness, hypnogogic hallucinations and cataplexy.. Since 2012 the Claimant had been prescribed a range of medications to treat her condition including stimulants to help stay awake during the day, other drugs to assist with night-time sleep and further drugs for cataplexy. Unfortunately none of these were effective and in some cases the drugs caused negative side effects.. In May 2014 the Claimants NHS ...
https://www.hja.net/press-releases/17-year-old-woman-narcolepsy-refused-medication-funding-nhs-england/
Research « Narcolepsy NetworkResearch « Narcolepsy Network
Have you taken Xyrem within the past two years? Harvard Medical School and Brigham and Womens Hospital is currently conducting interviews to determine how FDA-mandated safety programs impact the prescribing and use of drugs like Xyrem.. Little is known about the impact of such programs on physicians, patients, and manufacturers, including whether they increase prescribing burdens, reduce patient access, enhance costs, or improve patients experiences with their illnesses. This study will seek to answer these questions. Participation will involve a 60-minute interview. Upon successful conclusion of the interview, study participants will receive a $50 Amazon gift card.. If you have received Xyrem within the past two years, you may be eligible. For more information, please contact the study principal investigator, Dr. Ameet Sarpatwari at [email protected].. Research Study is Enrolling to Evaluate Medications for Excessive Daytime Sleepiness ...
http://narcolepsynetwork.org/get-involved/research-participation/
Human Gene MOG (uc011gpl.2) Description and Page IndexHuman Gene MOG (uc011gpl.2) Description and Page Index
DISEASE: Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by mutations affecting the gene represented in this entry ...
http://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011gpl.2&hgg_prot=Q16653&hgg_chrom=chr6_mann_hap4&hgg_start=927717&hgg_end=943106&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
RLS/PLMD and Narcolepsy/Cataplexy - Restless Legs Syndrome (RLS) Discussion Board
I dont know if my RLS has changed, I know that I had previously, years ago, had a very bad case, which this previous regimine controlled for years. When I went off of all the drugs it was torture, but when I started the xyrem it was amazing, for the first time I really slept (narcolptics dont get any slow wave sleep, and have many abnormal rem onsets in sleep, etc). And then my whole life changed in the months after xyrem, whereas before I couldnt work or drive, now I could. It didnt just help my cataplexy it gor rid of the completly debilitating sleepiness of narcolepsy. Yes my RLS may have changed, but because I am now facing a situation where I could loose my livilhood, my dr said ok, lets just go back to the old regimne. The thing is it is helping the rls, and I am getting to seep, as I said before, but now Im tired today, and have been for the last 3 days, but I think Im not getting quality sleep, so tonight I will try backing off the xyrem...Im on the top dose, and see i thats ...
http://bb.rls.org/viewtopic.php?p=1005
Cell Transplantation: A Future Therapy for Narcolepsy? | Bentham ScienceCell Transplantation: A Future Therapy for Narcolepsy? | Bentham Science
Title: Cell Transplantation: A Future Therapy for Narcolepsy?. VOLUME: 8 ISSUE: 4. Author(s):Oscar Arias-Carrion and Eric Murillo-Rodriguez. Affiliation:Experimental Neurology, Biomedical Research Center (BMFZ), Philipps University, Hans Meerwein Str., D-35043 Marburg, Germany.. Keywords:hypocretin/orexin neurons, narcolepsy, sleep, lateral hypothalamus, animal models, cell transplant. Abstract: Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep-onset rapid eye movement (REM) sleep periods. Narcolepsy is now identified to be a neurodegenerative disease, as there is a massive loss of neurons containing the neuropeptide, hypocretin/orexin. Orexin neurons are solely located in the hypothalamus, particularly in its perifornical, dorsomedial and lateral portions. Orexin fibers widely project throughout the brain and generally have excitatory effects on their postsynaptic cells. Patients with narcolepsy have a severe reduction ...
https://www.eurekaselect.com/93396/article
Narcolepsy<...Narcolepsy<...
TY - JOUR. T1 - Narcolepsy. AU - Thorpy, Michael J.. PY - 2007/6/1. Y1 - 2007/6/1. N2 - Narcolepsy is a neurologic disorder that is incurable and therefore requires lifelong treatment. Excessive daytime sleepiness is the most common symptom and can be partially controlled by medications. The pathognomonic symptom of narcolepsy is cataplexy, emotionally induced muscle weakness, which can be the most disabling symptom for many patients. Also, hallucinations that typically occur at sleep onset or muscle paralysis that occurs upon awakening from sleep, called sleep paralysis, occur in many patients. Additional symptoms include fragmented nocturnal sleep and episodes of automatic behavior. Narcolepsy typically has its onset in the first 2 decades of life and may commonly be misdiagnosed. It produces reduced quality of life and, because of the sleepiness, can interfere with memory, concentration, and other cognitive abilities. The cataplexy may predispose the patient to injury because of the muscle ...
https://einstein.pure.elsevier.com/en/publications/narcolepsy-2
Narcolepsy/FertilitypediaNarcolepsy/Fertilitypedia
Narcolepsy is a chronic neurological disorder with unknown exact cause. Symptoms include periods of excessive daytime sleepiness that usually last from seconds to minutes and may occur at any time. About 70% of people also experience episodes of sudden loss of muscle strength, known as cataplexy. These spells can be brought on by strong emotions. Less commonly there may be inability to move or vivid hallucinations while falling asleep or waking up. People with narcolepsy tend to sleep about the same number of hours per day as people without, but the quality of sleep tends to be worse.. Diagnostic tests are carried out in the sleep clinic in order to measure each of these symptoms, thereby confirming presence of narcolepsy in patients. Diagnosis can be confirmed by polysomnography (Pic. 1) for assessing night-time sleep followed by a multiple sleep latency test to evaluate daytime sleep attacks lasting for a short period of time (Pic. 2). Mild cases of narcolepsy can be managed with regular naps, ...
https://fertilitypedia.org/edu/symptoms/narcolepsy
New Clues to Cause of Human Narcolepsy - U Magazine - UCLA Health - Los Angeles, CANew Clues to Cause of Human Narcolepsy - U Magazine - UCLA Health - Los Angeles, CA
Jerome Siegel, PhD, director of the Center for Sleep Research at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, and colleagues found that people with the disorder have nearly 65 percent more brain cells containing the chemical histamine. Their research suggests that this excess of histamine cells causes the loss of hypocretin cells in human narcoleptics.. Narcolepsy is a chronic disorder of the central nervous system that is believed to affect one-in-3,000 Americans. It is characterized by the brains inability to control sleep-wake cycles, causing sudden bouts of sleep. It often is accompanied by cataplexy, an abrupt loss of voluntary muscle tone that can cause a person to collapse.. Histamine is a body chemical that works as part of the immune system to kill invading cells. When the immune system goes awry, histamine can act on a persons eyes, nose, throat, lungs, skin or gastrointestinal tract, causing the symptoms of allergy that are familiar to many people. ...
https://www.uclahealth.org/u-magazine/new-clues-to-cause-of-human-narcolepsy
Sleep, Introduction, sleep disorders, narcolepsy, what is narcolepsy, causes of narcolepsy, how narcolepsy affects peoples...
Sleep Disorders. Narcolepsy. INtroduction to narcolepsy. what is narcolepsy? Causes of narcolepsy. How narcolepsy affects peoples lives?
http://holisticonline.com/Remedies/Sleep/sleep_narc_introduction.htm
Narcolepsy DSM-5 347.00 (ICD-10-CM Multiple Codes) - TherapediaNarcolepsy DSM-5 347.00 (ICD-10-CM Multiple Codes) - Therapedia
According to the DSM-5, (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), narcolepsy is a disorder in which the individual will experience recurrent periods of an irresistible need to sleep, or will fall asleep, or nap within the same day, regardless of whether or not the time and place are appropriate. These episodes must occur at least three times per week over the past three months, accompanied by at least one of the following symptoms:. 1. Episodes of cataplexy, or loss of muscle tonus, occurring several times a month, episodes lasting seconds to minutes of sudden full body loss of skeletal muscle tone without LOC (Loss Of Consciousness) that are precipitated by an episode of strong emotion. 2. In children or in individuals within six months of narcolepsy onset, involuntary grimacing or jaw-opening with tongue thrusting, or hypotonia, in the absence of clear emotional triggers.3. Objective measure of hypocretin deficiency in the cerebrospinal fluid (CSF) as defined by ...
https://www.theravive.com/therapedia/narcolepsy-dsm--5-347.00-
Submission to the FDAs Regarding Hypersomnias | Hypersomnia FoundationSubmission to the FDAs Regarding Hypersomnias | Hypersomnia Foundation
We are clinician scientists board certified both in Sleep Medicine and Neurology with a combined 30 years of clinical experience that includes a particular focus on narcolepsy and related disorders collectively referred to as the central hypersomnias. We are well published in the area and regularly participate in the annual patient conferences of the Narcolepsy Network. We join with our patients in thanking you for your effort to reach out for input regarding the disease state(s) and especially the unmet needs of the patients who we treat. Having viewed the webcast of the recent September 24th public meeting on narcolepsy patient-focused drug development, we would like to add our voice to those of others.. Excessive daytime sleepiness remains common and the socioeconomic burden to the individual, family, and society is large. Unfortunately, while routine sleep laboratory testing for genuine narcolepsy with cataplexy is sensitive, it is becoming clear that it is highly nonspecific. The ...
https://www.hypersomniafoundation.org/submission-to-the-fdas-regarding-hypersomnias/
I need your help please - I cannot get a diagnosis. - Condition | Our HealthI need your help please - I cannot get a diagnosis. - Condition | Our Health
What I meant about making yourself faint was...Can you manufacture a situation where you are certain to faint. Such as standing up fast, bending over etc. Have you ever fainted at the doctors office? I think You need to be hospitalized, hooked up to a monitor, blood pressure and oxygen saturation machines etc. Your physical parameters should change if you have witnessed syncope. (fainting). Narcolepsy as a possible diagnosis is interesting, as a symptom of it is called cataplexy. The most severe attacks result in a complete loss of tone in all voluntary muscles, leading to total physical collapse in which patients are unable to move, speak, or keep their eyes open. But even during the most severe episodes, people remain fully conscious, a characteristic that distinguishes cataplexy from seizure disorders. Although cataplexy can occur spontaneously, it is more often triggered by sudden, strong emotions such as fear, anger, stress, excitement, or humor. Laughter is reportedly the most frequent ...
http://www.ourhealth.com/conditions/i-cannot-get-a-diagnosis/i-need-your-help-please-1
Propranolol in the Treatment of Narcolepsy | Annals of Internal Medicine | American College of PhysiciansPropranolol in the Treatment of Narcolepsy | Annals of Internal Medicine | American College of Physicians
Narcolepsy is being treated with stimulant drugs (amphetamines or methylphenidate) to control the excessive daytime sleepiness and sleep attacks, and imipramine to manage auxiliary symptoms, particularly cataplexy (1). The potentials for tolerance and dependence with the stimulants and cardiotoxicity from imipramine underscore the need for other therapies.. In 1978, we administered propranolol to a narcoleptic patient to treat premature ventricular contractions; a detailed report has been published elsewhere (2). When a relatively low dose of propranolol reduced the frequency of narcoleptic and cataplectic attacks, we gradually increased the dose. At a daily dose of about 300 mg, the attacks were ...
http://annals.org/aim/article-abstract/693501/propranolol-treatment-narcolepsy
Body Weight Regulation in Patients With Narcolepsy - Full Text View - ClinicalTrials.govBody Weight Regulation in Patients With Narcolepsy - Full Text View - ClinicalTrials.gov
BACKGROUND: Several cross-sectional studies have suggested that subjects with narcolepsy have increased body mass index (BMI) and insulin resistance. These subjects exhibit a decrease in cerebrospinal fluid (CSF) orexin levels, which has been causally linked to the clinical manifestations of this disease. Orexins are peptides expressed in a brain region, the lateral hypothalamic area, which stimulate appetite and modulate sleep. Low CSF orexin levels provoke narcolepsy-like behavior, such as excessive daytime sleepiness and a sudden loss of muscle tone known as cataplexy.. OBJECTIVES: The primary objective of this study is to determine whether subjects with narcolepsy have lower energy expenditure compared to healthy matched controls. In addition, we will assess food intake, physical activity, and other relevant parameters.. STUDY POPULATION: 18 to 55 year old men and premenopausal women with narcolepsy and healthy matched controls. DESIGN: This is a cross-sectional, case-controlled study of ...
https://clinicaltrials.gov/ct2/show/NCT00283894?term=heart+attack&lup_s=04%2F22%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14
Body Weight Regulation in Patients With Narcolepsy - Full Text View - ClinicalTrials.govBody Weight Regulation in Patients With Narcolepsy - Full Text View - ClinicalTrials.gov
BACKGROUND: Several cross-sectional studies have suggested that subjects with narcolepsy have increased body mass index (BMI) and insulin resistance. These subjects exhibit a decrease in cerebrospinal fluid (CSF) orexin levels, which has been causally linked to the clinical manifestations of this disease. Orexins are peptides expressed in a brain region, the lateral hypothalamic area, which stimulate appetite and modulate sleep. Low CSF orexin levels provoke narcolepsy-like behavior, such as excessive daytime sleepiness and a sudden loss of muscle tone known as cataplexy.. OBJECTIVES: The primary objective of this study is to determine whether subjects with narcolepsy have lower energy expenditure compared to healthy matched controls. In addition, we will assess food intake, physical activity, and other relevant parameters.. STUDY POPULATION: 18 to 55 year old men and premenopausal women with narcolepsy and healthy matched controls. DESIGN: This is a cross-sectional, case-controlled study of ...
https://clinicaltrials.gov/ct2/show/NCT00283894?cond=%22narcolepsy%22&rank=3
WHO urges investigation into link between flu shots, narcolepsy - FierceVaccinesWHO urges investigation into link between flu shots, narcolepsy - FierceVaccines
As 12 nations have reported suspected cases of narcolepsy linked to swine flu vaccination, World Health Organization scientists are saying more investigation is warranted. However, the health body has decided to keep its advice in favor of vaccination because it still believes the benefits outweigh a relatively small risk, spokeswoman Alison Brunier said, as quoted by AFP.. Concerns have been heightened since Finland, Sweden and Iceland reported an uptick in narcolepsy cases in youths between the ages of 4 and 19. Finlands National Institute for Health and Welfare says there is a link between GlaxoSmithKlines Pandemrix flu vaccine and a spike in narcolepsy cases. Narcolepsy is a disorder that causes a person to fall asleep suddenly and unexpectedly.. In a statement, the WHO points out narcolepsy is typically seen in persons who have a certain genotype. Of the cases of narcolepsy tested so far in Finland (n=22), diagnosed during 2009-2010, all have that genotype. The National Institute ...
http://www.fiercevaccines.com/node/8689/print/
ncreased risk of narcolepsy observed among children and adolescents vaccinated with PandemrixRncreased risk of narcolepsy observed among children and adolescents vaccinated with PandemrixR
Press release by THL, Finnish National Institute of Health and Welfare. 1 Feb 2011 http://www.thl.fi/doc/en/24103. Among those 4-19 years of age who received Pandemrix -vaccine had a manifold increased risk of falling ill with narcolepsy during the 8 months following vaccination in comparison to those unvaccinated in the same age group. Based on the evaluation done so far, the National Narcolepsy Task Force finds it probable that Pandemrix -vaccination contributed to the observed increase in incidence of narcolepsy among those 4 -19 years of age. Currently, the most likely explanation is that the increase in narcolepsy is by joint effect of the vaccine and some other factor(s). At the moment, there is no evidence that the increase in narcolepsy observed in Finland could be attributed to the vaccine lots used. The results can be read in the Interim Report of the Task Force which is published on February 1st, 2011.. The association of Pandemrix-vaccination and narcolepsy was studied using ...
http://www.whale.to/vaccine/narcolepsy5.html
Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy...Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy...
Increased narcolepsy incidence was observed in Sweden following the 2009 influenza vaccination with Pandemrix(®). A substitution of the 2009 nucleoprotein for the 1934 variant has been implicated in narcolepsy development. The aims were to determine (a) antibody levels toward wild-type A/H1N1-2009[A/California/04/2009(H1N1)] (NP-CA2009) and Pandemrix-[A/Puerto Rico/8/1934(H1N1)] (NP-PR1934) nucleoproteins in 43 patients and 64 age-matched controls; (b) antibody affinity in reciprocal competitive assays in 11 childhood narcolepsy patients compared with 21 age-matched controls; and (c) antibody levels toward wild-type A/H1N1-2009[A/California/04/2009(H1N1)] (H1N1 NS1), not a component of the Pandemrix vaccine. In vitro transcribed and translated (35)S-methionine-labeled H1N1 influenza A virus proteins were used in radiobinding reciprocal competition assays to estimate antibody levels and affinity (Kd). Childhood patients had higher NP-CA2009 (p = 0.0339) and NP-PR1934 (p = 0.0246) antibody levels ...
https://portal.research.lu.se/portal/en/publications/antibody-affinity-against-2009-ah1n1-influenza-and-pandemrix-vaccine-nucleoproteins-differs-between-childhood-narcolepsy-patients-and-controls
The Difference Between Narcolepsy Type 1 and 2The Difference Between Narcolepsy Type 1 and 2
What is the difference between narcolepsy type 1 and type 2? Learn about the role of cataplexy and testing for hypocretin levels measured in CSF.
https://www.verywell.com/what-is-the-difference-between-narcolepsy-type-1-and-2-3014836
Sleepy Sarah: My Life with Narcolepsy Part 1: The Beginning | Yoga Pants Mafia
When I started writing on this blog, I wasnt sure how much of my self I wanted to share and what information I wanted to put out there for 10 people the world to read (and possibly judge). However, lately Ive been having more and more issues and I feel like I need to get it out there. This is partly to provide some sort of understanding about me and my daily life, and partly as a therapeutic release for myself. So heres my story…. I have narcolepsy. Most people I talk to have little to no idea what the hell that even is, so I will give you a rundown. Disclaimer- I am not a medical professional so please excuse my simplified description. Narcolepsy is a sleep/neurologic disorder that affects every single second of my life. It causes me to have unrestful sleep and excessive daytime sleepiness (EDS). Here is a more technical definition for you from the experts: Narcolepsy is a chronic brain disorder that involves poor control of sleep-wake cycles. People with narcolepsy experience periods of ...
http://yogapantsmafia.com/sleepy-sarah-narcolepsy-part-1/?replytocom=125
Sleepy Sarah: My Life with Narcolepsy Part 1: The Beginning | Yoga Pants Mafia
When I started writing on this blog, I wasnt sure how much of my self I wanted to share and what information I wanted to put out there for 10 people the world to read (and possibly judge). However, lately Ive been having more and more issues and I feel like I need to get it out there. This is partly to provide some sort of understanding about me and my daily life, and partly as a therapeutic release for myself. So heres my story…. I have narcolepsy. Most people I talk to have little to no idea what the hell that even is, so I will give you a rundown. Disclaimer- I am not a medical professional so please excuse my simplified description. Narcolepsy is a sleep/neurologic disorder that affects every single second of my life. It causes me to have unrestful sleep and excessive daytime sleepiness (EDS). Here is a more technical definition for you from the experts: Narcolepsy is a chronic brain disorder that involves poor control of sleep-wake cycles. People with narcolepsy experience periods of ...
http://yogapantsmafia.com/sleepy-sarah-narcolepsy-part-1/?replytocom=127
Narcolepsy symptoms, treatments & forums | PatientsLikeMeNarcolepsy symptoms, treatments & forums | PatientsLikeMe
Narcolepsy: Find the most comprehensive real-world symptom and treatment data on narcolepsy at PatientsLikeMe. 1321 patients with narcolepsy experience fatigue, anxious mood, depressed mood, pain, and excessive daytime sleepiness (somnolence) and use Modafinil, Amphetamine-Dextroamphetamine, Armodafinil, Methylphenidate, and Lisdexamfetamine to treat their narcolepsy and its symptoms.
https://www.patientslikeme.com/conditions/narcolepsy
Sleep DisordersSleep Disorders
Testing to diagnose type 1 narcolepsy. Orexin is a neuropeptide produced in the hypothalamus and is involved in the sleep/wake cycle in humans. Impairment of orexin production and orexin-modulated neurotransmission is associated with narcolepsy with cataplexy. An abnormally low concentration of orexin-A/hypocretin-1 in cerebrospinal fluid (CSF) is indicative of type 1 narcolepsy. The low CSF orexin-A/hypocretin-1 assay has over 90% sensitivity and specificity for the diagnosis of type 1 narcolepsy ...
https://news.mayocliniclabs.com/neurology/sleep-disorders/
Adrafinil - Smarter NootropicsAdrafinil - Smarter Nootropics
Adrafinil is a mild stimulant of the central nervous system commonly used to prevent sleepiness in Narcolepsy patients. Narcolepsy is characterized by excessive daytime sleepiness. Adrafinil successfully combats this, and can be used in a similar way on individuals without Narcolepsy. Adrafinil is metabolized into Modafinil while passing through the body, and essentially has the same effects; such as alertness, an increase in cognitive abilities, and an increase of energy. Adrafinil does however take longer to become active due to the time it takes the metabolite to become active in the bloodstream, which is typically 45-60 minutes.. Scientists working for Group Lafon, a French pharmaceutical company, first discovered Adrafinil in the late 1970s. The drug became available in France in 1986 as an experimental treatment for narcolepsy. The same company later made Modafinil. Adrafinil is now currently marketed as Olmifon in France and Europe.. Reactions to Adrafinil vary, though often it works very ...
https://www.smarternootropics.com/table-of-contents/adrafinil/
Nail bed biopsyNail bed biopsy
I started this blog in 2008 so Id have a place to record my thoughts. I have a sleep disorder called Narcolepsy, and I also have Cataplexy. The Cataplexy causes me to become weak to the point of paralysis in response to sudden emotion, most notably laughter, being startled, sudden anger, etc. This disorder has had a great impact on my life, and this blog is about how I deal with it all. Thanks for taking the time to read, and I hope you enjoy! ~ ...
http://fromthelipsofme.blogspot.com/2009/03/nail-bed-biopsy.html
Narcolepsy Linked to Brain Cell Loss - ABC NewsNarcolepsy Linked to Brain Cell Loss - ABC News
Missing Neurons in Hypothalamus. The people with narcolepsy were missing neurons found in the hypothalamus region of the brain that secrete hypocretin, Siegel reported in the journal Neuron.. There are none to be seen - basically zero in the patient, Kitt said.. This tied in with findings by Dr. Emmanuel Mignot and colleagues at Stanford University, who in 1999 found that a lack of hypocretin caused narcolepsy in dogs, and who reported today they had confirmed it causes narcolepsy in people.. They also found the hypocretin-producing cells were missing in human patients.. We think that theres something that specifically kills the cells that make hypocretin. We dont know how or why, but its most likely an autoimmune disease, said Mignot, who reported the findings in the journal Nature Medicine.. Cells Attack Healthy Tissue. Siegel and Kitt agreed that an autoimmune disorder, in which the bodys immune cells mistakenly attack healthy tissue, may be to blame.. Narcolepsy can have an onset in ...
https://abcnews.go.com/Health/story?id=118014
Narcolepsy Therapeutics Market Is Expected To Grow Substantially Owing To The Rising Awareness About Sleep Disorder Among...Narcolepsy Therapeutics Market Is Expected To Grow Substantially Owing To The Rising Awareness About Sleep Disorder Among...
The Global Narcolepsy Therapeutics Market is expected to reach USD 3.85 billion by 2025, according to a new report by Grand View Research, Inc. The increasing awareness about this sleep disorder among public and healthcare providers is a key factor contributing to the market growth.. The Narcolepsy Network has estimated that out of every 2,000 people 1 is afflicted by this condition. Moreover, Narcolepsy UK states that around 25% patients are identified and remaining 75% are untreated as they remain undiagnosed or are misdiagnosed, which is alarming. Some organizations and networks are constantly working to spread awareness about this condition among the patients and physicians.. Full Research Report on Global Narcolepsy Therapeutics Market Analysis ...
http://www.marylandnewsdesk.com/story/150618/narcolepsy-therapeutics-market-is-expected-to-grow-substantially-owing-to-the-rising-awareness-about-sleep-disorder-among-public-healthcare-providers-till-2025-grand-view-research-inc.html
Sleep, conventional treatment of narcolepsy, pharmacological and non-pharmacological treatments for narcolepsy, sleep...
Sleep Disorders. Narcolepsy. conventional treatment of narcolepsy include both pharmacological and non-pharmacological treatments for narcolepsy.
http://holisticonline.com/Remedies/Sleep/sleep_narc_conv_treatment.htm
Narcolepsy - Home
Understand that although media may portray a funny and characteristic picture of narcolepsy, it is rarely a laughing matter. Movies often show persons with narcolepsy going from energetic one minute to asleep the next. Generally, persons with narcolepsy will be more even-keel, instead spending most of their time extremely tired. This feeling has been compared to a normal person staying awake for three days straight and then trying to resume their normal activities. Put those shoes on and it makes it easier to understand how a person with narcolepsy consistently feels ...
http://www.moonscentral.net/Home/Narcolepsy
Narcolepsy Sample Report covering Narcolepsy epidemiology from 2017 to 2030.Narcolepsy Sample Report covering Narcolepsy epidemiology from 2017 to 2030.
Dowload Sample Page for Narcolepsy epidemiology analysis. This report contains Narcolepsy incidence/prevalence and country specific Narcolepsy treatment algorithms.
https://www.delveinsight.com/sample-request/narcolepsy-epidemiology-forecast
3 Ways to Manage Narcolepsy Symptoms - wikiHow3 Ways to Manage Narcolepsy Symptoms - wikiHow
How to Manage Narcolepsy Symptoms. Narcolepsy is a neurological disorder characterized by a disruptive sleep pattern, lower quality of sleep, and excessive daytime sleepiness. Individuals suffering from narcolepsy may experience daytime...
https://www.wikihow.com/Manage-Narcolepsy-Symptoms
Plus itPlus it
The novel findings presented in this study are: 1) a population difference between patients with narcolepsy-cataplexy and age-matched controls with regard to hypoxic chemosensitivity; and 2) an association between DQB1*0602 and acute ventilatory responsiveness to progressive hypoxia. While narcolepsy-cataplexy patients do have different sleep values, AHI and lowest arterial ozygen saturation (Sa,O2) were not defining factors for the group differences in ventilatory chemosensitivity.. Contrary to results obtained in hypocretin gene knockout mice, hypercapnia responses were not affected by disease or marker state. Unlike knockout mice, where both the gene and protein are absent, in patients with narcolepsy, hypocretin-1 is often detected at some level in the CSF 9. We suspect that the effects of hypocretin on chemoresponsiveness, if present, are below a threshold for detection.. Our findings implicate DQB1*0602, or a gene located nearby, as a regulator of hypoxic responses. While DQB1*0602 is an ...
http://erj.ersjournals.com/content/36/3/577
UCLA Researchers Discover Link Between Parkinsons And Narcolepsy | EmaxHealth
More than 1 million people in the U.S. have been diagnosed with Parkinsons disease, and approximately 20 million worldwide. (The percentage of those afflicted increases with age.)-- Narcolepsy affects approximately one in 2,000 individuals --- about 150,000 in the United States and 3 million worldwide. Its main symptoms are sleep attacks, nighttime sleeplessness and cataplexy, the sudden loss of skeletal muscle tone without loss of consciousness; that is, although the person cannot talk or move, they are otherwise in a state of high alertness, feeling, hearing and remembering everything that is going on around them.. When we think of Parkinsons, the first thing that comes to mind are the motor disorders associated with it, said Siegel, who is also chief of neurobiology research at the Sepulveda Veterans Affairs Medical Center in Mission Hills, Calif. But sleep disruption is a major problem in Parkinsons, often more disturbing than its motor symptoms. And most Parkinsons patients have ...
https://www.emaxhealth.com/39/11759.html
narcolepsy Disease Ontology Browser - DOID:8986narcolepsy Disease Ontology Browser - DOID:8986
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: Narcolepsy, without cataplexy; paroxysmal sleep
http://www.informatics.jax.org/disease/DOID:8986
NarcolepsyNarcolepsy
Narcolepsy is a sleep disorder. It is a lifelong disease of the central nervous system. Narcolepsy causes excessive and overwhelming daytime sleepiness, even after getting plenty of nighttime sleep. If you have narcolepsy, you are likely to become drowsy or to fall asleep at inappropriate times and places. These sleep attacks may happen with or without warning.
https://healthlibrary.uwmedicine.org/Search/85,P01317
Narcolepsy Causes | Treatment for Narcolepsy
Narcolepsy is also called uncontrollable daytime sleepiness. Depressed mood and Inability to concentrate these are the main Symptoms of Narcolepsy
http://cpapbipapindia.com/sleeping-disorders/narcolepsy/
Narcolepsy | MedicalRecords.comNarcolepsy | MedicalRecords.com
Narcolepsy is a disabling sleep disorder that mixes the nervous systems messages about when to sleep and when to be awake. Narcolepsy usually starts during the teen years or early adulthood and continues throughout life. Narcolepsy may cause: Sudden sleep attacks. These may occur at any time during any type of...
https://www.medicalrecords.com/health-a-to-z/narcolepsy-symptom
The Medications For Narcolepsy Mount Vernon NY - Mount Vernon NY, narcolepsy symptoms, Mount Vernon NY narcolepsy cause, Mount...
Do you want to know more about the most effective and available medications for narcolepsy symptoms. Well, you have come to the right place. There are, in fact, a widely scattered group of medications that can be found on different online sites.
http://guides.wkbw.com/The_Medications_For_Narcolepsy_Mount_Vernon_NY-r989296-Mount_Vernon_NY.html
Causes of narcolepsy
Narcolepsy may be associated with damage to the amygdala. There is hereditary cause to the occurrence of narcolepsy. Gene that causes narcolepsy has been identified.
http://neurology.health-cares.net/narcolepsy-causes.php
Doi:10.1016/s0006-3223(02)01740-7
cord have been reported (van den Pol 1999), but even if Lower CSF hypocretin levels (hypocretin-1 levels Ͻ110 spinal release occurs, the cell bodies located in the lateral pg/mL) have been shown to be diagnostic for narcolepsy hypothalamic area are likely to be active during the active period. This would not explain the discrepancy between indicate that the time of day at which sampling is done is unlikely to interfere with this test. The data should be Hypocretins are uniquely positioned for involvement in considered preliminary because of the relatively small depression. Whereas hypocretin cell bodies are all local- number of patients and the differences in times of collec- ized within the perifornical area, extremely dense, almost tion initiation between control subjects and depressed invariably excitatory projections are noted in aminergic cell groups (e.g., adrenergic locus coeruleus, serotonergic Surprisingly, the direction of the hypocretin diurnal raphe´ nuclei, histaminergic ...
http://pdfdrug.com/g/geneqol-consortium.org1.html
GSK Flu Shot May Raise Adult Narcolepsy Risk Say Finnish Scientists | GSK : Licence To (K) ill (Documenting GSK And Seroxat)
http://www.reuters.com/article/2013/05/23/us-gsk-vaccine-narcolepsy-idUSBRE94M0FJ20130523 (Reuters) - GlaxoSmithKline Plcs H1N1 pandemic flu shot may put adults at higher risk of developing narcolepsy, not only children as previous studies found, Finlands National Institute for Health and Welfare said on Thursday. Growing evidence of a link between GSKs Pandemrix vaccine and an increase in narcolepsy, a rare sleep disorder, among children…
https://truthman30.wordpress.com/2013/05/23/gsk-flu-shot-may-raise-adult-narcolepsy-risk-say-finnish-scientists/
Epidemiology of Narcolepsy | SpringerLinkEpidemiology of Narcolepsy | SpringerLink
This chapter provides an overview of the epidemiology of narcolepsy. Narcolepsy is characterized by excessive sleepiness with episodic weakness often triggered by strong emotions. Due to difficulty...
https://link.springer.com/chapter/10.1007/978-1-4419-0854-4_4
Plus it
A 12 year old boy who developed narcolepsy and cataplexy after being vaccinated against swine flu at age 7 has been awarded £120 000 (€165 000; $186 000) in compensation, in a ruling that opens the way for dozens of similar awards from the United Kingdoms statutory vaccine damage compensation scheme.. Claims by the unnamed boy and dozens of others who developed the chronic neurological disorders after being given the vaccine Pandemrix during the swine flu outbreak in 2009-10 had … ...
http://www.bmj.com/content/350/bmj.h3205
Paul MacPaul Mac
In February 2019, Mac released a new single titled "Cataplexy" and confirmed a new album is coming soon. In April, Mac ... "Cataplexy - single". iTunes Australia. 15 February 2019. Retrieved 19 April 2019. "Flamenco - single". iTunes Australia. 12 ...
https://en.wikipedia.org/wiki/Paul_Mac
Idiopathic hypersomniaIdiopathic hypersomnia
Unlike narcolepsy with cataplexy, which has a known cause (autoimmune destruction of hypocretin-producing neurons), the cause ... The prevalence of narcolepsy (with cataplexy) is estimated between 1/3,300 and 1/5,000. Although the true prevalence of IH is ... This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with cataplexy, and ... "Narcolepsy-cataplexy". Retrieved 2014-08-14. "Idiopathic hypersomnia". Retrieved 2014-08-14. "Primary hypersomnia epidemiology ...
https://en.wikipedia.org/wiki/Idiopathic_hypersomnia
NarcolepsyNarcolepsy
The attacks of cataplexy in dogs can involve partial or full collapse. Narcolepsy with cataplexy was identified in a few breeds ... Narcolepsy paired with cataplexy is evidenced to be an autoimmune disorder. These experiences of cataplexy can be brought on by ... The antidepressant class is used mainly for the treatment of cataplexy, for people with narcolepsy without cataplexy these are ... differentiates between narcolepsy with cataplexy (type 1) and narcolepsy without cataplexy (type 2), while the fifth edition of ...
https://en.wikipedia.org/wiki/Narcolepsy
Gamma-Hydroxybutyric acidGamma-Hydroxybutyric acid
GHB has been used in the medical setting as a general anesthetic and as treatment for cataplexy, narcolepsy, and alcoholism. It ... "FDA Approval Letter for Xyrem; Indication: Cataplexy associated with narcolepsy; 17 July 2002" (PDF). Archived (PDF) from the ... Food and Drug Administration for the treatment of cataplexy associated with narcolepsy and excessive daytime sleepiness (EDS) ...
https://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid
Death from laughterDeath from laughter
See also laughter-induced syncope, cataplexy, and Bezold-Jarisch reflex. Gelastic seizures can be due to focal lesions to the ... Totah AR, Benbadis SR (January 2002). "Gelastic syncope mistaken for cataplexy". Sleep Med. 3 (1): 77-78. doi:10.1016/S1389- ... "Anomalous hypothalamic responses to humor in cataplexy". PLOS ONE. 3 (5): e2225. Bibcode:2008PLoSO...3.2225R. doi:10.1371/ ...
https://en.wikipedia.org/wiki/Death_from_laughter
Laughter-induced syncopeLaughter-induced syncope
Unlike syncope, there is no loss of consciousness in cataplexy, which affects 65-75% of patients with narcolepsy. To date there ... Laughter-induced syncope should not be confused with cataplexy, a sudden loss of muscle tone triggered by strong emotions, ... "Characterizing the Emotions That Trigger Cataplexy". Journal of Neuropsychiatry and Clinical Neurosciences. American ...
https://en.wikipedia.org/wiki/Laughter-induced_syncope
ClomipramineClomipramine
Body dysmorphic disorder Cataplexy associated with narcolepsy. Which is a TGA and MHRA-labeled indication for clomipramine. ...
https://en.wikipedia.org/wiki/Clomipramine
Norrie diseaseNorrie disease
Vossler DG, Wyler AR, Wilkus RJ, Gardner-Walker G, Vlcek BW (May 1996). "Cataplexy and monoamine oxidase deficiency in Norrie ...
https://en.wikipedia.org/wiki/Norrie_disease
Sodium oxybateSodium oxybate
Kane N (May 2017). "Sodium oxybate for the treatment of narcolepsy with cataplexy in adults" (PDF). NHS Regional Drug & ... Reviews of sodium oxybate concluded that it is well tolerated and associated with "significant reductions in cataplexy and ... "Narcolepsy with or without cataplexy in adults: pitolisant , Guidance and guidelines: Other Treatments". NICE. March 2017. ... cataplexy, weakness, nervousness or anxiety, depressed mood, nightmares or abnormal dreams, sleep paralysis, sleepwalking, or ...
https://en.wikipedia.org/wiki/Sodium_oxybate
ZimelidineZimelidine
... was reported by Montplaisir and Godbout to be very effective for cataplexy in 1986, back when this was usually ... Zimelidine was able to improve cataplexy without causing daytime sleepiness. Most often reported were: Dry mouth, dryness of ... Godbout R, Montplaisir J (1986). "The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness ...
https://en.wikipedia.org/wiki/Zimelidine
SuvorexantSuvorexant
Narcolepsy with cataplexy, also known as type 1 narcolepsy, is thought to be caused by loss of orexin-producing neurons in the ... Similarly, narcolepsy with cataplexy in dogs is caused by a mutation in the gene encoding the OX2 receptor, and knockout mice ... In addition, little to no cataplexy has been observed even with high doses of orexin receptor antagonists in animals and humans ... Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, and ...
https://en.wikipedia.org/wiki/Suvorexant
H3 receptor antagonistH3 receptor antagonist
Cataplexy, hypnagogic hallucinations and sleep paralysis can also be present in narcolepsy. H3R antagonism leads to histamine ...
https://en.wikipedia.org/wiki/H3_receptor_antagonist
The Mysterious Benedict Society (TV series)The Mysterious Benedict Society (TV series)
He has type 1 narcolepsy with cataplexy and faints when experiencing intense emotions. Assisted by his trusty associates, ...
https://en.wikipedia.org/wiki/The_Mysterious_Benedict_Society_(TV_series)
Prader-Willi syndromePrader-Willi syndrome
"Case Study: Cataplexy and SOREMPs Without Excessive Daytime Sleepiness in Prader Willi Syndrome. Is This the Beginning of ...
https://en.wikipedia.org/wiki/Prader–Willi_syndrome
ViloxazineViloxazine
In narcolepsy, viloxazine has been shown to suppress auxiliary symptoms such as cataplexy and also abnormal sleep-onset REM ... In 1984, the FDA granted the medication an orphan designation for treatment of cataplexy and narcolepsy with the tentative ... In a cross-over trial (56 participants) viloxazine significantly reduced EDS and cataplexy. Viloxazine has also been studied ...
https://en.wikipedia.org/wiki/Viloxazine
Genetics of obesityGenetics of obesity
"Case Study: Cataplexy and SOREMPs Without Excessive Daytime Sleepiness in Prader Willi Syndrome. Is This the Beginning of ...
https://en.wikipedia.org/wiki/Genetics_of_obesity
Autosomal dominant cerebellar ataxia, deafness, and narcolepsyAutosomal dominant cerebellar ataxia, deafness, and narcolepsy
January 2020). "Cataplexy and ataxia: red flags for the diagnosis of DNA methyltransferase 1 mutation". Journal of Clinical ... Usually, people with this disorder have ataxia, mild-moderate sensorineural hearing loss, narcolepsy, and cataplexy. These ... narcolepsy with cataplexy, and dementia later in life. People with this disorder usually start showing symptoms when they are ...
https://en.wikipedia.org/wiki/Autosomal_dominant_cerebellar_ataxia,_deafness,_and_narcolepsy
Eugenia Martínez VallejoEugenia Martínez Vallejo
"Case Study: Cataplexy and SOREMPs Without Excessive Daytime Sleepiness in Prader Willi Syndrome. Is This the Beginning of ...
https://en.wikipedia.org/wiki/Eugenia_Martínez_Vallejo
ObesityObesity
"Case Study: Cataplexy and SOREMPs Without Excessive Daytime Sleepiness in Prader Willi Syndrome. Is This the Beginning of ...
https://en.wikipedia.org/wiki/Obesity
XywavXywav
... is indicated for the treatment of cataplexy in people aged seven years of age and older with narcolepsy. In August 2021, ... Xywav, is a medication used to treat cataplexy or excessive daytime sleepiness (EDS). It contains a mixture of oxybate salts, ... Oral Solution for Cataplexy or Excessive Daytime Sleepiness Associated with Narcolepsy". Retrieved 20 September 2022. Portal: ...
https://en.wikipedia.org/wiki/Xywav
HLA B7-DR15-DQ6HLA B7-DR15-DQ6
... narcolepsy-cataplexy Hypocretin ligand deficiency in the brain and cerebrospinal fluid is also link to narcolepsy-cataplexy. ... Nishino S, Kanbayashi T (August 2005). "Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the ...
https://en.wikipedia.org/wiki/HLA_B7-DR15-DQ6
Clinical neurochemistryClinical neurochemistry
Cataplexy, on the other hand, is an involuntary loss of muscle tone during wakefulness. The mechanism of narcolepsy is unknown ...
https://en.wikipedia.org/wiki/Clinical_neurochemistry
Out-of-body experienceOut-of-body experience
Other scientists have also linked OBEs to cases of hypnagogia and sleep paralysis (cataplexy). In case studies fantasy ...
https://en.wikipedia.org/wiki/Out-of-body_experience
Human leukocyte antigenHuman leukocyte antigen
March 2001). "Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups". American Journal ...
https://en.wikipedia.org/wiki/Human_leukocyte_antigen
Carl Friedrich Otto WestphalCarl Friedrich Otto Westphal
"English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th ... He was the first physician to provide a clinical description of narcolepsy and cataplexy (1877). French physician Jean-Baptiste ...
https://en.wikipedia.org/wiki/Carl_Friedrich_Otto_Westphal
Penfield mood organPenfield mood organ
... as a weapon for inducing cataplexy. The name of the device is a reference to the neurosurgeon Wilder Penfield. Dick also ...
https://en.wikipedia.org/wiki/Penfield_mood_organ
Dorsal raphe nucleusDorsal raphe nucleus
Cataplexy is the symptom of narcolepsy when full awareness of the environment is maintained, but all muscle tone is lost. This ... "Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs". J. Physiol. 554 (Pt 1 ...
https://en.wikipedia.org/wiki/Dorsal_raphe_nucleus
Niemann-Pick diseaseNiemann-Pick disease
Gelastic cataplexy, the sudden loss of muscle tone when the affected patient laughs, is also seen.[citation needed] Mutations ...
https://en.wikipedia.org/wiki/Niemann–Pick_disease
Mesencephalic locomotor regionMesencephalic locomotor region
... cataplexy, and Parkinsonism". Frontiers in Neurology. 6 (140): 140. doi:10.3389/fneur.2015.00140. PMC 4478394. PMID 26157418. ... cataplexy, and Parkinsonism". Frontiers in Neurology. 6 (140): 140. doi:10.3389/fneur.2015.00140. PMC 4478394. PMID 26157418. ...
https://en.wikipedia.org/wiki/Mesencephalic_locomotor_region
FluoxetineFluoxetine
It has also been used for cataplexy, obesity, and alcohol dependence, as well as binge eating disorder. Fluoxetine seems to be ...
https://en.wikipedia.org/wiki/Fluoxetine
Presentation of Cataplexy in Patients With NarcolepsyPresentation of Cataplexy in Patients With Narcolepsy
... experts in sleep medicine provide insight on ways cataplexy can present in patients with narcolepsy. ... Haramandeep Singh, MD: When we talk about classic cataplexy, we know that cataplexy generally doesnt present in this manner. ... Cataplexy is a symptom where if they say no, then I say, "I want you to think about this. I want you to ask the people around ... Cataplexy is any muscle weakness with a strong emotion. It can occur with laughter and anger, which are the most common. But it ...
https://www.psychiatrictimes.com/view/presentation-of-cataplexy-in-patients-with-narcolepsy
Isolated Cataplexy in the Differential Diagnosis of Drop Attacks: A Case of Successful Clinical Diagnosis and TreatmentIsolated Cataplexy in the Differential Diagnosis of Drop Attacks: A Case of Successful Clinical Diagnosis and Treatment
We report a patient with the rare condition of cataplexy without associated narcolepsy (isolated cataplexy). Isolated cataplexy ... Cataplexy, which is usually associated with narcolepsy, is one of the causes of drop attacks. ... We report a patient with the rare condition of cataplexy without associated narcolepsy (isolated cataplexy). Isolated cataplexy ... A. V. Bueno, J. C. Castello, and R. J. Baos, "Hereditary cataplexy: is it primary cataplexy?" Waking and Sleeping, vol. 2, no. ...
https://www.hindawi.com/journals/crinm/2012/757586/
Cataplexy Overview: Definition, Symptoms, and Causes - 2022 - MasterClassCataplexy Overview: Definition, Symptoms, and Causes - 2022 - MasterClass
Cataplexy is a symptom common among people with narcolepsy; its clinical features include a sudden loss of muscle tone and ... Cataplexy is a symptom common among people with narcolepsy; its clinical features include a sudden loss of muscle tone and ...
https://www.masterclass.com/articles/cataplexy
cataplexy | The Addi and Cassi Fund - Niemann Pick Type Ccataplexy | The Addi and Cassi Fund - Niemann Pick Type C
You are here: Home / Archives for cataplexy. A Little Girl From Beirut. July 4, 2008 by Chris Hempel Filed under NPC Family ...
https://addiandcassi.com/tag/cataplexy/
Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy | Clinical Research Trial Listing (...Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy | Clinical Research Trial Listing (...
Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy ... Clinical trial for Cataplexy , Excessive Daytime Sleepiness , Narcolepsy , ... They must discontinue all anti cataplexy drugs. Yes for They must discontinue all anti cataplexy drugs inclusion criteria 9 ... Yes for For NT1 only, current continuing presence of cataplexy as defined by subject report for the last 3 months inclusion ...
https://www.centerwatch.com/clinical-trials/listings/90063/excessive-daytime-sleepiness-sodium-oxybate-treatment-excessive/?page=4&query=Torento&featured=true&rnk=32&us_intern=international&con_state=Canada
Narcolepsy and Cataplexy: Information for Adults and Families : Renfrew County, ON : eMentalHealth.ca
For cataplexy, medications can be used such as: *Sodium oxybate (sodium salt of gamma hydroxybutyrate, GHB), which is felt to ... Cataplexy is thought to be related to the muscle paralysis of REM sleep intruding abnormally in wakefulness. Up to 70% of those ... Cataplexy: Sudden brief episodes of muscle weakness that occur with a strong emotional trigger. Triggers include laughter, ... These people, however, will not have cataplexy.. As a result, narcolepsy can cause significant problems with all aspects of ...
https://www.ementalhealth.ca/Prescott-and-Russell-County/Narcolepsy-and-Cataplexy/index.php?m=article&ID=60970&r=renfrew
Jazz Pharmaceuticals Announces First Patient Enrolled in Phase 3 Clinical Study Evaluating JZP-258 for the Treatment of...Jazz Pharmaceuticals Announces First Patient Enrolled in Phase 3 Clinical Study Evaluating JZP-258 for the Treatment of...
Activity of putative orexin neurons during cataplexy | Molecular Brain | Full TextActivity of putative orexin neurons during cataplexy | Molecular Brain | Full Text
... show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy- ... during the cataplexy-like episode. We propose that the activity of orexin neurons during cataplexy is moderately inhibited by ... The absence of cataplexy in wild-type mice may be explained by basal or residual activity-induced orexin release, and emotional ... To test this hypothesis, we measured the activity of putative orexin neurons in orexin-knockout mice during cataplexy episodes ...
https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-022-00907-w
Narcolepsy Clinical Presentation: History, Physical ExaminationNarcolepsy Clinical Presentation: History, Physical Examination
... cataplexy, hypnagogic hallucinations, and sleep paralysis. Narcolepsy is thought to result from genetic predisposition, ... Cataplexy. Cataplexy is a brief and sudden loss of muscle tone and represents REM sleep intrusion during wakefulness. If severe ... Cataplexy is seen in about 70% of patients with narcolepsy. Its presence in conjunction with EDS strongly suggests the ... Cataplexy and monoamine oxidase deficiency in Norrie disease. Neurology. 1996 May. 46(5):1258-61. [QxMD MEDLINE Link]. ...
http://emedicine.medscape.com/article/1188433-clinical
Cataplexy - ACPNCataplexy - ACPN
Cataplexy may make your head nod or make it hard for you to speak. Muscle weakness also may make your knees weak or cause you ... Cataplexy. This condition causes loss of muscle tone while youre awake. Muscle weakness occurs in certain parts of your body ... Cataplexy may make your head nod or make it hard for you to speak. Muscle weakness also may make your knees weak or cause you ... Cataplexy may occur weeks to years after you first start to have extreme daytime sleepiness. ...
https://americancenteruae.com/health-education/cataplexy/
Cataplexy - Sleepy TeensCataplexy - Sleepy Teens
Category: Cataplexy. Cataplexy and Panic Attacks. Im the type of Narcoleptic that needs more intense emotion to experience ... Cataplexy and Rollercoasters. I get the weirdest Cataplexy episodes when I ride rollercoasters. At this point, I find it ... What is Cataplexy?. Cataplexy occurs when someone is experiencing some type of strong emotion; like excitement, anger, or ... Everybody is different, and so some people can get Cataplexy from a normal amount of emotion, or an extreme amount. Then again ...
http://sleepyteens.org/category/cataplexy/
Day4NAPs - Narcolepsy, Cataplexy, Sleep DisordersDay4NAPs - Narcolepsy, Cataplexy, Sleep Disorders
Day4Naps is a clearinghouse for global narcolepsy awareness projects/events. Tell us about your project so that we can share it with the narcolepsy community.
https://day4naps.org/
Narcolepsy: MedlinePlus Medical EncyclopediaNarcolepsy: MedlinePlus Medical Encyclopedia
CATAPLEXY *During these attacks, you cant control your muscles and cant move. Strong emotions, such as laughter or anger, can ... Most people with narcolepsy have daytime sleepiness and cataplexy. Not everyone has all these symptoms. Surprisingly, despite ... Type 2 involves having excessive daytime sleepiness, but no cataplexy, and a normal level of hypocretin. ... Sodium oxybate (Xyrem) works well to control cataplexy. It can also help control daytime sleepiness. ...
https://medlineplus.gov/ency/article/000802.htm
Primary Hypersomnia Clinical Presentation: History, Physical ExaminationPrimary Hypersomnia Clinical Presentation: History, Physical Examination
... but without cataplexy, sleep paralysis, or sleep-onset rapid eye movement (REM), should not be considered narcoleptic. In 1972 ... Montplaisir J, Poirier G. HLA in disorders of excessive sleepiness without cataplexy in Canada. Honda Y, Juti T. HLA in ... A comparison of idiopathic hypersomnia and narcolepsy-cataplexy using self report measures and sleep diary data. J Neurol ... Nishino S, Kanbayashi T. Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic ...
https://www.medscape.com/answers/291699-190748/which-clinical-history-findings-are-characteristic-of-primary-hypersomnia
Narcolepsy Awareness Video 5: Communicating about Cataplexy - Julie Flygare
Narcolepsy Awareness Video 5: Communicating about Cataplexy By julie , December 7, 2012 , 13 ... Posted in Blog, Cataplexy, Communicating Narcolepsy, Narcolepsy, Narcolepsy Awareness, Narcolepsy Blog, News/Media, REM Runner ... Heres my latest awareness video offering tips on communicating about cataplexy. Make sure to view in 1080p HD. Watch on ... Watch Video #4: What is Cataplexy?. Watch Video #3: Communicating Invisible Symptoms. Watch Video #2: Excessive Daytime ...
https://julieflygare.com/narcolepsy-awareness-video-5-communicating-cataplexy/
Sexual Health and Narcolepsy With Cataplexy: A Male PerspectiveSexual Health and Narcolepsy With Cataplexy: A Male Perspective
The intense physical and emotional aspects of sex and orgasm can trigger cataplexy in people with type 1 narcolepsy. An ...
https://narcolepsy.sleep-disorders.net/living/sexual-health-male-perspective
Cataplexy Versus Pseudoseizure by Sammar Atassi and Katherine Atassi"Cataplexy Versus Pseudoseizure" by Sammar Atassi and Katherine Atassi
This case study about a young patient shows the necessary steps needed to accurately diagnose and treat cataplexy as well as ... Cataplexy is frequently misdiagnosed as pseudo seizures. This case study about a young patient shows the necessary steps needed ... Atassi S, Atassi K. Cataplexy versus Pseudoseizure : A Case Study. MJM. 6(4): 19 DOI: https://doi.org/10.33470/2379-9536.1268. ... to accurately diagnose and treat cataplexy as well as understand the differences between narcolepsy Type I and Type II. ...
https://mds.marshall.edu/mjm/vol6/iss4/5/
Suppression of Motor Evoked Potential and H-reflex during Cataplexy in NarcolepsySuppression of Motor Evoked Potential and H-reflex during Cataplexy in Narcolepsy
Conclusion: Suppression of both MEP and H-reflex during cataplexy indicates that postsynaptic spinal motor neuron inhibition is ... the main pathomechanism underlying cataplexy. Keywords: Narcolepsy , Cataplexy , Transcranial magnetic stimulation , Motor ... Objectives: To investigate the electrophysiologic mechanism of cataplexy, the authors measured motor evoked potential (MEP) and ... Suppression of Motor Evoked Potential and H-reflex during Cataplexy in Narcolepsy. ...
https://www.e-jsm.org/journal/view.php?number=62
6 Steps for Setting a Consistent Sleep Schedule6 Steps for Setting a Consistent Sleep Schedule
Cienna is living with narcolepsy with cataplexy and a pan hypothalamic disorder. In this piece, she talks about the importance ...
https://www.healthline.com/health/daytime-sleepiness/set-a-consistent-sleep-schedule?utm_source=ReadNext
How Epilepsy is DiagnosedHow Epilepsy is Diagnosed
Narcolepsy With Cataplexy Narcolepsy is a sleep disorder that causes episodes of extreme sleepiness in which you may fall ... One way to differentiate between the two is that cataplexy usually occurs after youve experienced a strong emotion, like ... When you have narcolepsy with cataplexy, called type 1 narcolepsy, you also experience sudden partial or complete loss of ...
https://www.verywellhealth.com/diagnosis-of-epilepsy-1745309
Caldwell AB - Search Results - PubMedCaldwell AB - Search Results - PubMed
Narcolepsy-cataplexy. II. Psychosocial consequences and associated psychopathology. Kales A, Soldatos CR, Bixler EO, Caldwell A ...
https://pubmed.ncbi.nlm.nih.gov/?term=Caldwell+AB&cauthor_id=7447621
Excuse Me Waiter - Theres a Fly in My Vaccine Soup! - SaneVax, Inc.Excuse Me Waiter - There's a Fly in My Vaccine Soup! - SaneVax, Inc.
Narcolepsy and Cataplexy after Gardasil?. Categories. Categories. Select Category. Citizens Speak (73). Cervical Cancer Debate ...
https://sanevax.org/excuse-me-waiter-theres-a-fly-in-my-vaccine-soup/
Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy - Full Text View...Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy - Full Text View...
Narcolepsy Excessive Daytime Sleepiness Cataplexy Narcolepsy Drug: mazindol extended release Drug: Placebo Phase 2 ... Use of any medications that could affect the evaluation of cataplexy. *Received an investigational drug in the past 30 days or ... Cataplexy. Sleepiness. Sleep Disorders, Intrinsic. Dyssomnias. Sleep Wake Disorders. Nervous System Diseases. Mental Disorders ...
https://clinicaltrials.gov/ct2/show/NCT04923594
David Kemlink - NeL.eduDavid Kemlink - NeL.edu
Journal Article 2006; 27(1-2): 174-176 PubMed PMID: 16648807 Keywords: Adolescent, Adult, Aged, Cataplexy:complications, ... Cataplexy treated with escitalopram--clinical experience.. Sonka K, Kemlink D, Pretl M. ... BACKGROUND: Narcolepsy with cataplexy is a debilitating sleep disease of which some symptoms can be treated with ... Sonka K, Kemlink D, Pretl M. Cataplexy treated with escitalopram--clinical experience. Neuro Endocrinol Lett. 2006 Apr; 27(1-2 ...
https://www.nel.edu/kemlink-8552/?vp-page=2
Dr. Mutaz Tabbaa, MD - Neurology Specialist in Panama City, FL | HealthgradesDr. Mutaz Tabbaa, MD - Neurology Specialist in Panama City, FL | Healthgrades
Narcolepsy and Cataplexy. *Nausea. *Neck Strain (incl. Whiplash Injury). *Nerve Conduction Studies ...
https://www.healthgrades.com/physician/dr-mutaz-tabbaa-ysfxs
Dr. Richard Schumann Jr, MD | Neurology in San Diego, CA | Healthline FindCareDr. Richard Schumann Jr, MD | Neurology in San Diego, CA | Healthline FindCare
What a Narcoleptic Dog Can Teach Us About Sleep | KQEDWhat a Narcoleptic Dog Can Teach Us About Sleep | KQED
Thats called cataplexy. Its a symptom thats classic of narcolepsy.. Like going on the beach. We often go to the beach and he ... You make this cataplexy sound cute and charming. But is it painful for him, or stressful? ... But another symptom is cataplexy, right?. Yes. When Watson gets excited sometimes he becomes completely paralyzed. That happens ...
https://www.kqed.org/science/27145/what-a-narcoleptic-dog-can-teach-us-about-sleep
Another simple introduction to Narcolepsy and Cataplexy to help explain to children and young people - General - Living with...Another simple introduction to Narcolepsy and Cataplexy to help explain to children and young people - General - Living with...
Another simple introduction to Narcolepsy and Cataplexy to help explain to children and young people General ...
https://forum.livingwithnarcolepsy.org/t/another-simple-introduction-to-narcolepsy-and-cataplexy-to-help-explain-to-children-and-young-people/300
SymptomSymptomsParalysisSleepinessTreat cataplexyTrigger cataplexyEpisodesNarcolepsy awarenessOnsetDisorderPsychosocialAttacksClinicallyAssociated with narcolepsyHypocretinSudden loss of muscle toneLaughterEmotionsSodium OxybateSeizuresCharacteristicAwarenessOrexinPeopleEmotionMechanismInhibitionCollapseTreatmentConditionTypeMuscle toneTermRarelyConsciousnessExperienceStartPatients
Symptom5
  • Cataplexy is a symptom where if they say no, then I say, "I want you to think about this. (psychiatrictimes.com)
  • Sometimes you've got to get third-party history to get the symptom of cataplexy. (psychiatrictimes.com)
  • The International Classification of Sleep Disorders-2 considers cataplexy as the hallmark symptom of the narcolepsy syndrome [ 3 ]. (hindawi.com)
  • Excessive daytime sleepiness is usually (but not always) the first symptom to appear, while cataplexy may be delayed in onset 1-30 years. (hindawi.com)
  • But another symptom is cataplexy, right? (kqed.org)
Symptoms5
  • Narcolepsy with cataplexy is a debilitating sleep disease of which some symptoms can be treated with antidepressants. (nel.edu)
  • I had it with just sleepiness during the day and what looked like insomnia at night for probably about 15-20 years before I ended up with more serious symptoms of narcolepsy that actually included cataplexy (random muscle weakness that can either be isolated, or widespread). (medhelp.org)
  • In other words, the more cardio you do, the less sleepy you might feel during the day and the less likely you are to experience cataplexy, one of narcolepsy's common symptoms . (psychcentral.com)
  • Medicines are available to control or relieve many symptoms such as cataplexy and seizures. (ssa.gov)
  • She was diagnosed with type 2 narcolepsy without cataplexy at age 24, but lived with symptoms for many years before that. (project-sleep.com)
Paralysis6
  • Cataplexy is most often associated with narcolepsy (excessive daytime sleepiness) as a major component of the narcolepsy tetrad that also includes sleep paralysis and hypnagogic hallucinations. (hindawi.com)
  • Cataplexy is thought to be related to the muscle paralysis of REM sleep intruding abnormally in wakefulness. (ementalhealth.ca)
  • The classic tetrad of narcolepsy consists of excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, and sleep paralysis. (medscape.com)
  • Antidepressant medicines can help reduce episodes of cataplexy, sleep paralysis, and hallucinations. (medlineplus.gov)
  • Features of narcolepsy include daytime sleepiness, sleep attacks, cataplexy (in narcolepsy type 1), sleep paralysis, and sleep-related hallucinations. (ccjm.org)
  • Cataplexy, sleep paralysis, and hypnagogic or hypnopompic hallucinations can also be present, 2 , 3 but they are not necessary for diagnosis. (ccjm.org)
Sleepiness8
  • The purpose of this study is to determine whether FT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy in subjects with narcolepsy. (centerwatch.com)
  • Up to 70% of those with narcolepsy have cataplexy, which can manifest together with daytime sleepiness, or develop later, even 5-10 years after sleepiness occurs. (ementalhealth.ca)
  • Cataplexy may occur weeks to years after you first start to have extreme daytime sleepiness. (americancenteruae.com)
  • Most people with narcolepsy have daytime sleepiness and cataplexy. (medlineplus.gov)
  • Type 1 involves having excessive daytime sleepiness, cataplexy, and a low level of hypocretin. (medlineplus.gov)
  • Modafinil, methylphenidate, and amphetamines are used to manage daytime sleepiness, and sodium oxybate and antidepressants are used for cataplexy. (ccjm.org)
  • Cataplexy usually has its onset at about the same time as the sleepiness associated with narcolepsy, but it can arise even years later. (ccjm.org)
  • Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities. (pinterest.com)
Treat cataplexy1
  • This case study about a young patient shows the necessary steps needed to accurately diagnose and treat cataplexy as well as understand the differences between narcolepsy Type I and Type II. (marshall.edu)
Trigger cataplexy2
  • Strong emotions, such as laughter or anger, can trigger cataplexy. (medlineplus.gov)
  • A range of emotions can trigger cataplexy, but typically the emotion is a positive one such as laughter or excitement. (ccjm.org)
Episodes6
  • Cataplexy: Sudden brief episodes of muscle weakness that occur with a strong emotional trigger. (ementalhealth.ca)
  • To test this hypothesis, we measured the activity of putative orexin neurons in orexin-knockout mice during cataplexy episodes using fiber photometry. (biomedcentral.com)
  • Although these observations fit the above hypothesis well, excitation of orexinergic neurons during cataplexy episodes in a time resolution of seconds has never been observed. (biomedcentral.com)
  • I get the weirdest Cataplexy episodes when I ride rollercoasters. (sleepyteens.org)
  • Cataplexy can worsen with stress and insufficient sleep, occasionally with "status cataplecticus," in which repeated, persistent episodes of cataplexy occur over several hours. (ccjm.org)
  • The cataplexy manifested first in my face, as what looked like episodes of Bells Palsy that came and went when I was tired, stressed, or even when I was happy and smiling. (medhelp.org)
Narcolepsy awareness1
Onset2
  • The activity of these putative orexin neurons increased immediately before the onset of cataplexy-like behavior but decreased (approximately − 20% of the baseline) during the cataplexy-like episode. (biomedcentral.com)
  • At disease onset, children with narcolepsy and cataplexy may display a wide range of motor disturbances that do not meet the classic definition of cataplexy. (medscape.com)
Disorder1
  • The sleep disorders screening tool was the major part of the Baseline survey, and included screening for obstructive sleep apnea, insomnia, restless leg syndrome, shift work disorder, and narcolepsy with cataplexy. (cdc.gov)
Psychosocial1
  • Narcolepsy-cataplexy psychosocial consequences and associatedpsychopathology. (bvsalud.org)
Attacks4
  • Cataplexy, which is usually associated with narcolepsy, is one of the causes of drop attacks. (hindawi.com)
  • Isolated cataplexy should be included in the differential diagnosis when a patient presents with recurrent drop attacks and normal diagnostic test results. (hindawi.com)
  • Sleep attacks," in which patients with narcolepsy may fall asleep suddenly, drowsiness, and cataplexy (sudden loss of muscle control) can lead to motor vehicle accidents. (rxlist.com)
  • [ 54 ] Whereas modafinil improved the quality of life in narcoleptic patients as compared with placebo, it did not diminish the number of attacks of cataplexy. (medscape.com)
Clinically2
  • The following case describes pitfalls in the diagnosis and management of a patient with clinically defined isolated cataplexy. (hindawi.com)
  • 9 Deep tendon reflexes disappear in cataplexy, so checking reflexes during a witnessed episode can be clinically valuable. (ccjm.org)
Associated with narcolepsy1
  • Cataplexy is frequently associated with NARCOLEPSY . (bvsalud.org)
Hypocretin1
  • Most people with narcolepsy along with cataplexy (sudden loss of muscle control) have very low levels of a naturally occurring chemical called hypocretin (also called orexin), that helps regulate wakefulness and sleep. (rxlist.com)
Sudden loss of muscle tone1
  • Cataplexy is a brief and sudden loss of muscle tone and represents REM sleep intrusion during wakefulness. (medscape.com)
Laughter1
  • The most characteristic feature of cataplexy is that it usually is triggered by emotions (especially laughter and anger). (medscape.com)
Emotions1
Sodium Oxybate1
Seizures1
  • Cataplexy is frequently misdiagnosed as pseudo seizures. (marshall.edu)
Characteristic1
  • Recurrent 'Bells Palsy' is actually very characteristic of narcolepsy with cataplexy. (medhelp.org)
Awareness1
  • Here's my latest awareness video offering tips on communicating about cataplexy. (julieflygare.com)
Orexin11
  • It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. (biomedcentral.com)
  • The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons. (biomedcentral.com)
  • We propose that the activity of orexin neurons during cataplexy is moderately inhibited by an unknown mechanism. (biomedcentral.com)
  • The absence of cataplexy in wild-type mice may be explained by basal or residual activity-induced orexin release, and emotional stimulus-induced counter activation of orexin neurons may not be necessary. (biomedcentral.com)
  • It is unclear why the absence of orexin neuronal transmission results in cataplexy. (biomedcentral.com)
  • An increase in orexin levels in the amygdala reduces cataplexy [ 5 ], indicating a cataplexy-inhibiting role for orexin neurons. (biomedcentral.com)
  • Lesion or inactivation of the amygdala in orexin-deficient mice reduced cataplexy [ 4 , 6 ], indicating a cataplexy-inducing role for amygdala neurons. (biomedcentral.com)
  • Therefore, changes in the heart rate during cataplexy may be a good indicator of the activity of orexin neurons. (biomedcentral.com)
  • In this context, a decrease in heart rate during cataplexy has been reported in narcolepsy patients [ 12 ] and narcolepsy dogs [ 13 ], indicating the inhibition of orexin neuronal activity during cataplexy, which is in contrast to the abovementioned counterbalance activation hypothesis. (biomedcentral.com)
  • As an extension of the system, we hypothesized that it would be possible to assess putative orexin neuronal activity in orexin-knockout mice during cataplexy. (biomedcentral.com)
  • Therefore, in this study, we measured putative orexin neuronal activity in two orexin-knockout mice models during cataplexy given that both activation and inhibition can be predicted from available circumstantial evidence. (biomedcentral.com)
People2
  • For other people, listening to music that's very moving to them can cause some cataplexy. (psychiatrictimes.com)
  • Everybody is different, and so some people can get Cataplexy from a normal amount of emotion, or an extreme amount. (sleepyteens.org)
Emotion4
  • Cataplexy is any muscle weakness with a strong emotion. (psychiatrictimes.com)
  • Any strong emotion that causes the muscle weakness is cataplexy. (psychiatrictimes.com)
  • I'm the type of Narcoleptic that needs more intense emotion to experience Cataplexy (not all Narcoleptics also have Cataplexy). (sleepyteens.org)
  • Cataplexy-transient muscle weakness triggered by emotion-is a specific feature of narcolepsy type 1. (ccjm.org)
Mechanism1
  • To investigate the electrophysiologic mechanism of cataplexy, the authors measured motor evoked potential (MEP) and H-reflex during asymptomatic, cataplectic and post-cataplectic periods in a narcolepsy patient. (e-jsm.org)
Inhibition1
  • Suppression of both MEP and H-reflex during cataplexy indicates that postsynaptic spinal motor neuron inhibition is the main pathomechanism underlying cataplexy. (e-jsm.org)
Collapse1
  • Cataplexy is an emotionally triggered loss of muscle strength and postural collapse threatening daily life of narcolepsy patients. (biomedcentral.com)
Treatment3
  • This study will serve as a basis for better treatment of cataplexy in narcolepsy patients. (biomedcentral.com)
  • [ 57 , 58 ] is the only treatment for cataplexy that has been approved by the US Food and Drug Administration (FDA). (medscape.com)
  • But if I wasn't on a good treatment plan, I'd probably I have a cataplexy attack every day. (woolcock.org.au)
Condition3
  • We report a patient with the rare condition of cataplexy without associated narcolepsy (isolated cataplexy). (hindawi.com)
  • The condition may also be categorized as mild, moderate, or severe on the basis of cataplexy frequency, urge to nap, and nocturnal sleep disturbance. (medscape.com)
  • Cataplexy is also a part of my condition. (woolcock.org.au)
Type3
  • 4 Narcolepsy is divided into type 1 (with cataplexy) and type 2 (without cataplexy). (ccjm.org)
  • She was diagnosed with type 1 narcolepsy with cataplexy in 2010 while living in Japan. (project-sleep.com)
  • He was diagnosed with type 1 narcolepsy with cataplexy at 20 years old. (project-sleep.com)
Muscle tone1
  • Cataplexy is a sudden and complete loss of muscle tone and strength. (epnet.com)
Term2
  • The term cataplexy is derived from the Latin word cataplessa (to strike down with fear or the like) and Greek kata-plexis (down-stroke). (hindawi.com)
  • Cataplexy is the term used to describe when your muscles go limp or feel weak without warning. (psychcentral.com)
Rarely1
  • Cataplexy is very specific to narcolepsy -- it is rarely seen in those without narcolepsy. (ementalhealth.ca)
Consciousness1
  • A patient presenting with acute recurrent falls without alteration of consciousness and with unremarkable cardiac, neurological, and electrophysiological testing should prompt consideration of cataplexy and narcolepsy. (hindawi.com)
Experience2
  • Cataplexy treated with escitalopram--clinical experience. (nel.edu)
  • Sonka K, Kemlink D, Pretl M. Cataplexy treated with escitalopram--clinical experience. (nel.edu)
Start2
Patients5
  • In this custom video series, experts in sleep medicine provide insight on ways cataplexy can present in patients with narcolepsy. (psychiatrictimes.com)
  • The other thing that's important to note is patients sometimes aren't the best historians about cataplexy. (psychiatrictimes.com)
  • When I talk to my patients, I'll ask them about cataplexy starting from the head and working my way down. (psychiatrictimes.com)
  • It's really important to get that history and document, with a detailed idea of what your patients are going through on a day-to-day basis in whatever aspect of their life that they're focused on, whether it's work or they have an incident of cataplexy at home. (psychiatrictimes.com)
  • Cataplexy is seen in about 70% of patients with narcolepsy. (medscape.com)
Narcolepsy: MedlinePlus Medical Encyclopedia
Narcolepsy: MedlinePlus Medical Encyclopedia (medlineplus.gov)
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Narcolepsy: Diagnosis and management | Cleveland Clinic Journal of Medicine
Narcolepsy: Diagnosis and management | Cleveland Clinic Journal of Medicine (ccjm.org)
Fibromyalgia Treatment & Management: Approach Considerations, Treatment of Children and Adolescents, Managing Flare-ups
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Modafinil Clinical Research Trials | CenterWatch (centerwatch.com)
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Neurologic Disease and Pregnancy: Overview, General Considerations, New-Onset Neurologic Complications (medscape.com)
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Fast Five Quiz: Narcolepsy (medscape.com)
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Stephen H Sheldon - Research Output - Northwestern Scholars (scholars.northwestern.edu)
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DailyMed - WAKIX- pitolisant hydrochloride tablet, film coated (dailymed.nlm.nih.gov)
These highlights do not include all the information needed to use WAKIX® safely and effectively. See full prescribing...
These highlights do not include all the information needed to use WAKIX® safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)
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Narcolepsy - About the Disease - Genetic and Rare Diseases Information Center (rarediseases.info.nih.gov)
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These highlights do not include all the information needed to use BELSOMRA safely and effectively. See full prescribing...
These highlights do not include all the information needed to use BELSOMRA safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)
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