A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.
A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)
A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
Relatively invariant mode of behavior elicited or determined by a particular situation; may be verbal, postural, or expressive.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.
Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias.
A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.
Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.
Drugs that bind to and activate dopamine receptors.
A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
Compounds containing phenyl-1-butanone.
A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.
The observable response an animal makes to any situation.
Cell surface proteins that bind neurotensin with high affinity and trigger intracellular changes which influence the behavior of cells. Neurotensin and neurotensin receptors are found in the central nervous system and in the periphery.
The bond or lack thereof between a pregnant woman and her FETUS.
A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.
Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.
An island in Micronesia, east of the Philippines, the largest and southernmost of the Marianas. Its capital is Agana. It was discovered by Magellan in 1521 and occupied by Spain in 1565. They ceded it to the United States in 1898. It is an unincorporated territory of the United States, administered by the Department of the Interior since 1950. The derivation of the name Guam is in dispute. (From Webster's New Geographical Dictionary, 1988, p471)
A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
The rear surface of an upright primate from the shoulders to the hip, or the dorsal surface of tetrapods.
The state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)
That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.
General or unspecified injuries to the posterior part of the trunk. It includes injuries to the muscles of the back.
A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.
The etiologic agent of CHOLERA.
An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.
The fundamental tenet of modern medicine that certain diseases are caused by microorganisms. It was confirmed by the work of Pasteur, Lister, and Koch.
A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)
A genus of VIBRIONACEAE, made up of short, slightly curved, motile, gram-negative rods. Various species produce cholera and other gastrointestinal disorders as well as abortion in sheep and cattle.
Fabric or other material used to cover the body.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Synergistic interactions between ampakines and antipsychotic drugs. (1/188)

Tests were made for interactions between antipsychotic drugs and compounds that enhance synaptic currents mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors ("ampakines"). Typical and atypical antipsychotic drugs decreased methamphetamine-induced hyperactivity in rats; the effects of near or even subthreshold doses of the antipsychotics were greatly enhanced by the ampakines. Interactions between the ampakine CX516 and low doses of different antipsychotics were generally additive and often synergistic. The ampakine did not exacerbate neuroleptic-induced catalepsy, indicating that the interaction between the different pharmacological classes was selective. These results suggest that positive modulators of cortical glutamatergic systems may be useful adjuncts in treating schizophrenia.  (+info)

Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. (2/188)

Atypical neuroleptics produce fewer extrapyramidal side-effects (EPS) than typical neuroleptics. The pharmacological profile of atypical neuroleptics is that they have equivalent or higher antagonist affinity for 5-HT2 than for dopamine D2 receptors. Our aim was to identify which 5-HT2 receptor contributed to the atypical profile. Catalepsy was defined as rats remaining immobile over a horizontal metal bar for at least 30 s, 90 min after dosing. Radioligand binding assays were carried out with homogenates of human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors expressed in Human Embryo Kidney (HEK293) cells. Haloperidol (1.13 mg kg(-1) i.p.) induced catalepsy in all experiments. The selective 5-HT2C/2B receptor antagonist, SB-228357 (0.32-10 mg kg(-1) p.o.) significantly reversed haloperidol-induced catalepsy whereas the 5-HT2A and 5-HT2B receptor antagonists, MDL-100907 (0.003-0.1 mg kg(-1) p.o.) and SB-215505 (0.1-3.2 mg kg(-1) p.o.) respectively did not reverse haloperidol-induced catalepsy. The data suggest a role for 5-HT2C receptors in the anticataleptic action of SB-228357.  (+info)

In vivo effects of new inhibitors of catechol-O-methyl transferase. (3/188)

1. The effects of two new synthetic compounds showing in vitro catechol-O-methyl transferase (COMT) inhibitor properties were studied in vivo and compared with the effects of nitecapone and Ro-41-0960. 2. QO IA (3-(3-hydroxy-4-methoxy-5-nitrobenzylidene)-2,4-pentanedione), QO IIR ([2-(3,4-dihydroxy-2-nitrophenyl)vinyl]phenyl ketone), nitecapone and Ro-41-0960 (30 mg kg(-1), i.p.) were given to reserpinized rats 1 h before the administration of L-DOPA/carbidopa (LD/CD, 50:50 mg kg(-1), i.p.). Locomotor activity was assessed 1 h later. All the COMT inhibitors (COMTI), with the exception of QO IA, markedly potentiated LD/CD reversal of reserpine-induced akinesia. Similar results were obtained when the COMTI were coadministered with LD/CD. The effect of compound QO IIR was dose-dependent (7.5-30 mg kg(-1), i.p.). 3. The COMTI (30 mg kg(-1), i.p.) potentiated LD/CD reversal of both catalepsy and hypothermia of reserpinized mice. 4. QO IIR, nitecapone and Ro-41-0960 (30 mg kg(-1), i.p.) reduced striatal 3-methyl-DOPA (3-OMD) levels and increased dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) levels. Compound QO IA was devoid of any effect on striatal amine levels. In contrast to the other inhibitors, Ro-41-0961 reduced HVA levels as well. The effect of QO IIR on striatal amine levels was dose-dependent (7.5-60 mg kg(-1), i.p.) 5. These results suggest that the new compound QO IIR is an effective peripherally acting COMT inhibitor in vivo.  (+info)

Effects of rubidium on behavioral responses to methamphetamine and tetrabenazine. (4/188)

Different groups of mice were injected subcutaneously every other day with rubidium chloride at three doses (0.41(50), 1.23(150) and 3.69(450) meq/kg (mg/kg)) or with saline as a control for a period of 2-3 weeks. Rubidium administered acutely did not affect spontaneous locomotor activities, while it tended to increase the activities when administered repeatedly though the increase was not statistically significant. The methamphetamine-induced hyperlocomotor activities were potentiated in the rubidium groups as compared with those in the saline group, this effect of ribidium being increased with prolongation of repeated administrations. Monotonic decreases in ambulation after tetrabenazine were not significantly affected in the rubidium-treated animals though the decreases were sometimes preceded by slight increases and recovery from the decrement tended to be more rapid. After tetrabenazine in the rubidium-treated groups, incidences of catalepsy were increased and jumping behavior and Straub tail responses occurred in a few cases. The results suggest that rubidium potentiates the excitatory action of methamphetamine on spontaneous locomotor activities, as contrasted with inhibitory influence of lithium.  (+info)

Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14. (5/188)

Previous studies have established that neuroleptic-induced catalepsy in mice is a highly heritable trait. The current study focuses on the detection of quantitative trait loci (QTL) for haloperidol-induced catalepsy in a BALB/cJ x LP/J F(2) intercross. One thousand thirty-seven F(2) animals were phenotyped and divided into four categories: very responsive (RR), responsive, nonresponsive, and very nonresponsive (NN). The RR and NN phenotypes comprised approximately 18% each of the total and differed in their haloperidol sensitivity by >10-fold. Sex differed significantly between the NN and RR groups (chi(2) = 14.0; p <.0002); females comprised 58% of the RR individuals but only 38% of the NN individuals. The difference between the extreme phenotypes in the number of piebald animals was highly significant (chi(2) = 30, p <. 00001). Eight percent of the RR individuals were piebald compared with 30% of the NN individuals. A genome wide scan confirmed the presence of a QTL (peak LOD = 6.4) on chromosome 14 near the piebald (Ednrb) and 5-hydroxytryptamine(2A) (Htr2a) loci. Although the parental BALB/cJ and LP/J strains differed significantly in striatal 5-hydroxytryptamine(2A) receptor binding, no marked differences were detected between the phenotypic extremes. A second QTL was detected on chromosome 14 (peak LOD = 6.9), which was located more proximally and included the Chat locus. No QTLs were detected on chromosomes 1 and 9, thus differentiating this cross from previous results obtained for a C57BL/6J x DBA/2J intercross.  (+info)

Enhanced cortical dopamine output and antipsychotic-like effects of raclopride by alpha2 adrenoceptor blockade. (6/188)

Clozapine exerts superior clinical efficacy and markedly enhances cortical dopamine output compared with classical antipsychotic drugs. Here the alpha2 adrenoceptor antagonist idazoxan was administered to rats alone or in combination with the D2/3 dopamine receptor antagonist raclopride. Dopamine efflux in the medial prefrontal cortex and conditioned avoidance responding were analyzed. Idazoxan selectively potentiated the cortical output of dopamine and augmented the suppression of conditioned avoidance responding induced by raclopride. These results challenge basic assumptions underlying the dopamine hypothesis of schizophrenia and provide insight into clozapine's mode of action.  (+info)

Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice. (7/188)

The cataleptic behavior induced by the dopamine D1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the "repeated measures effect," a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D1 antagonists. In this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This "injection-conditioned catalepsy" was also observed after repeated treatment with the dopamine D2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect.  (+info)

Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. (8/188)

Acute blockade of dopamine D(2) receptors by the typical antipsychotic drug haloperidol leads to alterations in neuronal gene expression and behavior. In the dorsolateral striatum, the levels of mRNA for the immediate-early gene c-fos and the neuropeptide gene neurotensin/neuromedin N (NT/N) are significantly increased by haloperidol. An acute behavioral response to haloperidol is catalepsy, considered to be a rodent correlate of some of the immediate extrapyramidal motor side effects seen in humans. Several lines of evidence suggest a link between neurotensin induction in the dorsolateral striatum and catalepsy. We hypothesize that both striatal gene induction and catalepsy elicited by haloperidol arise from the combined effect of excitatory adenosinergic and glutamatergic inputs acting at adenosine A(2A) and N-methyl-D-aspartate (NMDA) receptors, respectively. In agreement with our previous reports, adenosine antagonists reduced haloperidol-induced c-fos and neurotensin gene expression as well as catalepsy. In agreement with other reports, the noncompetitive NMDA receptor antagonist MK-801 also reduced gene expression and catalepsy in response to haloperidol. The competitive NMDA receptor antagonist LY235959 decreased haloperidol-induced catalepsy. We show here that blocking both A(2A) and NMDA receptors simultaneously in conjunction with haloperidol resulted in a combined effect on gene expression and behavior that was greater than that for block of either receptor alone. Both c-fos and NT/N mRNA levels were reduced, and catalepsy was completely abolished. These results indicate that the haloperidol-induced increases in c-fos and NT gene expression in the dorsolateral striatum and catalepsy are driven largely by adenosine and glutamatergic inputs acting at A(2A) and NMDA receptors.  (+info)

Uridine (15mg/kg/day, i.p.), haloperidol (1mg/kg/day, i.p.), uridine (15mg/kg/day, i.p.) plus haloperidol (1mg/kg/day, i.p.) or saline have been chronically administered to Sprague-Dawley male rats. Following 1 week of wash-out, the effects of these treatments on basal striatal dopamine (DA) release as well as on the DA release induced by an acute haloperidol challenge (2mg/kg, i.p.) were studied by means of intracerebral microdialysis. Behavioural tests such as haloperidol-induced catalepsy or apomorphine-induced stereotypics were also performed 4-7 days after drug withdrawal. The chronic treatment with uridine alone or associated with haloperidol markedly reduced DA release induced by an acute haloperidol challenge. The behavioural studies also indicated a change in DA-related behaviours in these conditions. The animals chronically treated with uridine showed significant increases in the stereotypy scores and in the catalepsy induced by an acute haloperidol challenge with respect to saline ...
Most behavioral, physiological and cellular effects of theneurotransmitter dopamine require concomitant activation of both D1 and D2 receptors, a phenomenon referred to as D1/D2 synergism. Since D1 and D2 receptors are located mostly on separate neurons, and since D1/D2 synergism occurs in the absence of action potentials, we have suggested that electrotonic coupling via gap junctions plays an important role in this phenomenon. A major constituent of gap junctions is connexin36 (Cx36), a protein that is abundant in neurons. The role Cx36 in D1/D2 synergism, as manifested behaviorally, was studied here in mice genetically engineered to express normal, reduced, or undetectable amounts of this protein. The results show that D1/D2 synergism and its breakdown were not affected by the presence or absence of Cx36. Unexpectedly, it was observed that the absence of Cx36 leads to resistance to the cataleptic effects of reserpine in a gene dosage-dependent manner.
Traducción de catalepsy | The term atypical was originally used to describe drugs that in animal models predict antipsychotic effects but do not
Noradrenergic involvement in dopamine-dependent stereotyped and cataleptic responses in the rat.: Two animal models were used to investigate the effect of lower
Populations from the Kii peninsula of Japan and Guam present a high incidence of amyotrophic lateral sclerosis and parkinsonism-dementia complex. It is thought that the low levels of calcium (Ca) and magnesium (Mg) in the drinking water are involved in the pathogenesis of these diseases. The present study aimed to test the hypothesis that catalepsy, a behavioral immobility and one of the Parkinsonian symptoms, may result from functionally impaired dopaminergic neurons in low Ca and Mg (LCa/Mg) fed mice. A group of mice fed with an LCa/Mg diet for 6 weeks was compared to a control group on a standard diet. Cataleptic symptoms such as akinesia and rigidity were measured using the bar test. The antiparkinsonian drugs dopamine (DA) precursor L-3, 4-dihydroxy phenylamine (L-DOPA), the selective DA receptor D2 agonist bromocriptine and the DA releaser amantadine were tested for their effects on the induced catalepsy. Mice developped catalepsy after 3 weeks on the LCa/Mg diet. LCa/Mg diet-induced catalepsy was
Dysphagia induces aspiration and causes aspiration pneumonia. There is no treatment for dysphagia fundamentally. Haloperidol reportedly induces dysphagia. In the present study, we established a haloperidol-induced dysphagia model in guinea pigs, and evaluated the effects of ginger, kikyoto, and a mixture of ginger and kikyoto on swallowing. Swallowing ability was evaluated using behavioral tests, computed tomography (CT), and videofluoroscopic examination of swallowing. To investigate the effect of ginger and kikyoto on swallowing, ginger, kikyoto, or a mixture of ginger and kikyoto was administered orally to guinea pigs with haloperidol-induced dysphagia. Effects of these compounds were evaluated with behavioral tests. Chronic administration of haloperidol reduced the number of swallows, as evaluated by the behavioral test and videofluoroscopic examination of swallowing. In our model, these compounds improved swallowing dysfunction. Our results suggest that this model might be useful in revealing the
Cyclohexamines work in a different manner than most other agents by stimulating the CNS rather than depressing it. This stimulation results in what is termed dissociative anesthesia or catalepsy, in which animals are in a trancelike state unaware of their surroundings. Stimulation of the CNS produces muscle rigidity characterized by extension of the front limbs and head and neck flexed back, increased reflexes such as the palpebral and pharyngeal, and sensitivity to light, sound, and touch. These effects can be diminished by using a benzodiazepine, opiate, or tranquilizer in combination with the cyclohexamine. Cyclohexamines typically do not cause cardiovascular depression. More often, tachycardia and increased blood pressure are seen after administration of a cyclohexamine due to indirect sympathetic stimulation. Because of this, they are not recommended for use in animals with known cardiac disease. Apneustic respirations are commonly seen. This is a particular type of breathing pattern in ...
EEG was registered in healthy volunteers before and after their entry into modeling (hypnotic) catalepsy. The brain activity recorded under standard electrode placement (the 10-20 international classification) was processed using a special computer program. The data obtained were digitally represented as sets of standard parameters of EEG patterns in 0,5-32 Hz diapason (alpha-, beta1-, beta2,-, theta-, delta-rythms). These parameters were compared under different functional tests particularly connected with the control of sensomotor brain activity ...
This letter interested me deeply, because the chief difficulty in the study of catalepsy is the rareness of the disease. You may believe, then, that I was in my consulting-room when, at the appointed hour, the page showed in the patient.. He was an elderly man, thin, demure, and commonplace - by no means the conception one forms of a Russian nobleman. I was much more struck by the appearance of his companion. This was a tall young man, surprisingly handsome, with a dark, fierce face, and the limbs and chest of a Hercules. He had his hand under the others arm as they entered, and helped him to a chair with a tenderness which one would hardly have expected from his appearance.. You will excuse my coming in, Doctor, said he to me, speaking English with a slight lisp. This is my father, and his health is a matter of the most overwhelming importance to me.. I was touched by this filial anxiety. You would, perhaps, care to remain during the consultation? said I.. Not for the world, he ...
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Looking for online definition of Extrapyramidal effect in the Medical Dictionary? Extrapyramidal effect explanation free. What is Extrapyramidal effect? Meaning of Extrapyramidal effect medical term. What does Extrapyramidal effect mean?
The primary objective of the study is to assess the safety and the anti-dyskinetic properties of sarizotan at various dosages for neuroleptic-induced TD.. The secondary objective of the study is to assess the effects of sarizotan on cognitive function in patients with neuroleptic-induced TD.. The diagnosis of neuroleptic-induced TD will be confirmed by history and physical examination. Patients will be evaluated at baseline, 2, 4, 8, and 12 weeks. Safety will be assessed by vital signs, ECG, routine blood tests, the ACTH stimulation test, and the clinicians and patients global impression of tolerability.. Procedures:. For efficacy, the primary outcome variable will be changes in the Abnormal Involuntary Movement Scale (AIMS), and a baseline score of ,3 (moderate) will be required for item 8 (Severity of Abnormal Movements). Quantitative evaluation of movements will be carried out in two ways. The first involves a series of instrumental and clinical measures that were developed as a battery ...
Umespirone (KC-9172) is a drug of the azapirone class which possesses anxiolytic and antipsychotic properties.[2][3][4][5] It behaves as a 5-HT1A receptor partial agonist (Ki = 15 nM), D2 receptor partial agonist (Ki = 23 nM), and α1-adrenoceptor receptor antagonist (Ki = 14 nM), and also has weak affinity for the sigma receptor (Ki = 558 nM).[2][6][7] Unlike many other anxiolytics and antipsychotics, umespirone produces minimal sedation, cognitive/memory impairment, catalepsy, and extrapyramidal symptoms.[1][5][6]. ...
bulbocapnine: was heading 1975-94 (Prov 1975-90); use APORPHINES to search BULBOCAPNINE 1975-94 (as Prov 1975-94); alkaloid from Corydalis cava and other plants; induces catalepsy probably due to its antagonism of DOPAMINE
Stress resistance can be lowered for some reason, it is not obvious to a person, and in this state, he is inclined to blame everything on himself.If the chorus of voices in his head be added and relatives to vote, the matter may even turn into a tragedy.Take care of your loved ones, be careful and lenient help a person regain confidence.. Disorders and Pathology apnea.Severe sleep disturbance, when a person during sleep may be interrupted breathing, he was afraid to fall asleep, waking up frequently during the night.Dream turns out defective, during the day there is a strong drowsiness.People with experience constant violation of lethargy during the day, can not concentrate, they complain of poor attention and memory.In this case, a person needs to pay attention to themselves and not to leave the sleep disorder without medical assistance.. There is such a disease as narcolepsy (catalepsy).People with this diagnosis acquire a disability as they can fall asleep suddenly, anywhere and in any ...
Haloperidol Teva is a medicine available in a number of countries worldwide. A list of US medications equivalent to Haloperidol Teva is available on the Drugs.com website.
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Objective:A few case reports on the use of aripiprazole in neuroleptic-induced tardive dyskinesia have demonstrated positive effects. However its effectiveness in treatment of TD was still inconclusive. The aim of the present study was to investigate the efficacy of aripiprazole in management of pre-existing neuroleptic-induced tardive dyskinesia.. Method: Subjects with pre-existing neuroleptic-induced tardive dyskinesia were chosen from Taoyuan psychiatric center. Patients recruited would be treated with aripiprazole for cross-titration with previous antipsychotics in 8 weeks. We use AIMS, SAS, & BAS to assess the severity of TF and EPS. We record subjects age, sex, and other factors which have influence at the treatment response. Subjects are assessed every two weeks in the first month and then monthly until six months. ...
TY - JOUR. T1 - Neurotoxic effects of methamphetamine. AU - Thrash, Bessy. AU - Karuppagounder, Senthilkumar S.. AU - Uthayathas, Subramaniam. AU - Suppiramaniam, Vishnu. AU - Dhanasekaran, Muralikrishnan. N1 - Funding Information: Acknowledgments This study was supported by the Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL.. PY - 2010/1. Y1 - 2010/1. N2 - In Parkinsons disease, depletion of dopamine in the striatum leads to various symptoms such as tremor, rigidity and akinesia. Methamphetamine use has significantly increased in USA and around the world and there are several reports showing that its long-term use increases the risk for dopamine depletion. However, the toxic mechanisms of methamphetamine are not well understood. This study was undertaken to gain greater mechanistic understanding of the toxicity induced by methamphetamine. We evaluated the effect of methamphetamine on the generation of reactive oxygen species, mitochondrial ...
The abdominal finite element model was created to improve the abdominal part of the human body model ROBBY that should ensure the ability to predict the abdominal injury during various impact conditions. The abdominal model geometry was created on the basis of real anatomical human data. Tissue characteristics completing the organ geometry were obtained from public sources. The created abdominal model was consequently scaled and embedded into the ROBBY model representing a 50th percentile male. The updated ROBBY model was validated with a comparison of the simulation results during abdominal oblique impactor tests and abdominal frontal rigid bar tests with available cadaver experimental results. It was found that the updated ROBBY model with the new deformable abdominal model is able to predict the response of the human abdomen during various impact conditions very well ...
(a and b) Evaluations of stereotyped behaviors of experimental rats during an 8-week period. Data are expressed as the mean ± SEM. (n = 10 rats/group). The ini
Haloperidol is used in the treatment of schizophrenia.get complete information about haloperidol including usage, side effects, drug interaction, expert advice along with medicines associated with haloperidol at 1mg.com
Its generally dosed to occupy less than 60% of D2 receptors, for unknown reasons and under serious debate. Its pretty effective at 40-50% binding, whereas haloperidol is effective at 80% ...
Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.
Extrapyramidal side effects are symptoms that can occur if you're taking antipsychotic medications. Here's what they include and how they're treated.
CBD Oil For Dystonia - How CBD works with Dystonia and Dyskinesias? In studies with mice, the natural cannabinoid CBD attenuated catalepsy, characterized by muscular rigidity
Sleep paralysis or projective catalepsy is not an illness - even conventional scientists agree. As such, it is not something that necessitates cure. It is something, however, that can indeed be suppressed. Sometimes people evoke certain historic or mythical personalities to give them courage and the power of their own intent to stop their re-occurrence is not to be dismissed. Many people, due to religious or materialistic inculcation do end up suppressing their psi abilities, especially as children. I suppose this is better than suffering due to the misinformation they have been fed. However, the ideal is to learn that there is, in fact, nothing to fear. This frees one to see actually enjoy multidimensionality, to de-mystify the whole thing and to have their own, healthy, productive experiences. We speak from personal experience, hundreds of our colleagues have overcome these fears sparked by the religious status quo. It is not convenient for institutions that control minds for people to ...
OXON HILL, Md. - Forget the spelling. Victoria Allen was looking for a punch line.. I only want a sentence if its funny, the 14-year-old from Green River, Wyoming, said upon getting the word salaam on Wednesday at the Scripps National Spelling Bee.. Well, replied pronouncer Jacques Bailly, checking his computer screen. I dont think I have one.. Shame, said Victoria, looking a tad disappointed - even though she correctly spelled the word.. The Big Bang Theory doesnt have a monopoly on nerd TV humor, not the way the Bee is going. The preliminary rounds were just as memorable for comedic sentences as for any spellings or misspellings of words like catalepsy or mastodon.. Andre promised to regale his friends with tales of his entire odyssey, Bailly told one speller, but it turned out just to be a 45-minute story about the time he got lost in Costco for 35 minutes.. After the laughter subsided, Lillian Allingham of Hockessin, Delaware, completed that bit of spelling odyssey ...
Clopixol (Zuclopenthixolum, Zuclopenthixole, Klopiksol) is a drug with antipsychotic activity. The active substance refers to tioksantenoviy derivatives.
Zajdel, P.; Marciniec, K.; Maslankiewicz, A.; Grychowska, K.; Satala, G.; Duszynska, B.; Lenda, T.; Siwek, A.; Nowak, G.; Partyka, A.; Wrobel, D.; Jastrzebska-Wiesek, M.; Bojarski, A. J.; Wesolowska, A.; Pawlowski, M. Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT(1A)/5-HT(2A)/5-HT(7) and dopamine D(2)/D(3) receptors. Eur. J. Med. Chem. 2013, 60, 42-50 (http://www.ncbi.nlm.nih.gov/pubmed/23279866) ...
The dosage that haloperidol is administered at depends on several factors including patient age, body weight and the condition for which the drug is being prescribed. Some examples of the dosage schedule for haloperidol are described below.
extrapyramidal definition: associated with or involving neural paths situated outside or independent of the pyramidal tracts.; Of or pertaining to the neural pathways which are independent of the pyramidal…
Pill with imprint ACEON 2 SLV SLV is White, Capsule-shape and has been identified as Aceon 2 mg. It is supplied by Solvay Pharmaceuticals Inc..
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JL13 [5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5] benzoxazepine fumarate] is a substance with a close structural resemblance to clozapine. However, it is less sensitive to oxidation and may therefore have less hematological side effects. In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia. The paw test represents a screening model for antipsychotic drugs that can discriminate between drugs with extrapyramidal side effects and drugs without. Haloperidol increased both forelimb retraction time and hindlimb retraction time (HRT), whereas both clozapine and JL13 increased only HRT. In the prepulse inhibition paradigm, all three drugs reversed the apomorphine- and the amphetamine-induced disruption of prepulse inhibition. However, whereas haloperidol was equally effective against both dopaminergic drugs, JL13 and clozapine were more effective against amphetamine. Finally, only JL13 was able to increase prepulse inhibition in ...
The present study investigated the potential sex differences in repeated aripiprazole (ARI) treatment-induced behavioral sensitization from adolescence to adulthood, and to determine whether ARI sensitization can be transferred to olanzapine (OLZ) and/or clozapine (CLZ) using the conditioned avoidance response (CAR) and phencyclidine-induced (PCP) hyperlocomotion tests of antipsychotic activity. Male and female Sprague-Dawley adolescence rats (P46) were first treated with ARI (10 mg/kg) for 5 consecutive days (P46-50) and tested for avoidance response and ARI-induced inhibition of PCP-induced hyperlocomotion. After they became adults (|P68), rats were challenged with ARI (1.5 mg/kg, sc) (P70), OLZ (0.5 mg/kg, sc; P73), CLZ (5 mg/kg, sc; P76) and again with ARI (1.5 mg/kg, sc; P84) and tested for avoidance response and ARI-induced inhibition of PCP-induced hyperlocomotion again. During the drug treatment period in adolescence, repeated ARI treatment suppressed avoidance response, inhibited the PCP
In previous times, masturbation received widespread condemnation. For example, in the 18th century, numerous treatises were written describing thephysical and mental consequences of masturbation (see Caird & Wincze,1977; Gagnon, 1977). It was during this time that a particularly well-knownSwiss physician, Tissot (1766), published a volume titled Onania, or a Trea-tise upon the Disorders Produced by Masturbation. Among the many physicaland mental disorders purportedly caused by masturbation were failing eye-sight, consumption, gonorrhea, hemorrhoids, digestive disorders, melancholy,catalepsy, imbecility, loss of sensation, lethargy, pervasive weakness of thenervous system, impotence, and insanity! Eventually, because of the scientificwork of Kinsey and others, more enlightened views about masturbationemerged. Today, in stark contrast, masturbation is prescribed as therapy (e.g.,see LoPiccolo & Lobitz, 1972; Zilbergeld, 1999). In fact, it turns out that di-rected masturbation (see Chapter 7) is a ...
Looking for Extrapyramidal System? Find out information about Extrapyramidal System. Descending tracts of nerve fibers arising in the cortex and subcortical motor areas of the brain. a group of brain structures in the hemispheres and... Explanation of Extrapyramidal System
Dystonic reactions are reversible extrapyramidal effects that can occur after administration of a neuroleptic drug. Symptoms may begin immediately or can be delayed hours to days. Although a wide vari... more
Higher affinity for D2 receptors (subsequently less blockade of 5-HT2), causing a greater effect on 'positive' symptoms' and a greater incidence of extrapyramidal side ...
Taking haloperidol can cause dangerous side effects or increase the risk of seizures in some people. This eMedTV resource discusses other precautions and warnings with haloperidol, including a list of people who should not take the drug at all.
(1-Benzyl-pyrrolidin-3-ylmethyl)-methyl-amine/ACM91189058 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
I was in the ED of my local hospital just the other day and the ER doc gave IV Benedryl and Phenergan at first(which didnt work) the he suggested that I give the Haldol a try. Well folks im here to tell you that it was the worse mistake I
Recite: Cover the note-taking column with a sheet of paper. Then, looking at the questions or cue-words in the question and cue column only, say aloud, in your own words, the answers to the questions, facts, or ideas indicated by the cue-words ...
TY - JOUR. T1 - Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra. AU - Bolden-Watson, Carolyn. AU - Watson, Michael A.. AU - Murray, Karl D. AU - Isackson, Paul J.. AU - Richelson, Elliott. PY - 1993/9. Y1 - 1993/9. N2 - We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels in the substantia nigra/ventral tegmental area (SN/ VTA) 110% over control levels (significant difference from the control, p , 0.05). In contrast, the same analysis applied to the sections from clozapine-treated animals showed no significant change in NTR mRNA levels compared with matched control sections (p , 0.05). Thus, chronic treatment with haloperidol but not clozapine resulted in elevated levels of NTR mRNA ...
Synonyms for stereotyped behavior at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
65).30 Honkaniemi et al compared haloperidol 5 mg in 500 mL NS IV to placebo/NS (500 mL) IV.31 Pain reduction (VAS) was greater with haloperidol (−55 vs −9; P < .001), with 80% of those receiving haloperidol reporting headache relief vs 15% of those given placebo (P < .001). Side effects of haloperidol included sedation. (53%) and akathisia (53%), with 16% unwilling to take haloperidol again (chiefly because of side effects). Table 2 shows the details of the studies on the butyrophenones. Metoclopramide is a neuroleptic/anti-emetic that is known to relieve gastroparesis and facilitate analgesic absorption.32 Common side effects include fluid retention (use with caution in patients with congestive heart failure and liver disease), lowered seizure threshold, hypertension, mild sedation, and extrapyramidal effects. Six studies compared metoclopramide 10 mg IV, 10 mg IM, or 20 mg PLX4032 PR as a single agent to placebo. Three studies showed metoclopramide to be superior to placebo. Tek et al ...
Rationale Clozapine and the atypical antipsychotics are less prone than neuroleptics to induce extrapyramidal motor effects, worsening of the negative symptoms of schizophrenia and dysphoria. This is paralleled by preclinical evidence showing reduced suppression of behaviours aimed at the pursuit of reward, with increased measures of reward efficacy. Serotonin 5-HT2 receptors seem to play a role in determining this profile ...
Disclaimer. Pallipedia does not endorse or recommend any commercial products, processes, or services; therefore, their mention cannot be construed as such. Pallipedia should not be used as guidance to treatment and its purpose is to provide users with information to help them better understand conditions and the current range of approaches related to palliative care. Pallipedia urges health care providers and patients to always consult other relevant and up-to-date experts.. Functional design and content: Roberto ...
The use of atypical antipsychotic drugs in kids (up to 18 years old) tipples the chances of getting type 2 diabetes later in life.
Haloperidol is a long-acting injection that is used to treat schizophrenia and other mental health problems. Haloperidol side effects and uses at Patient.
Jean-Martin Charcot made a similar distinction between stages which he named somnambulism, lethargy, and catalepsy. However, ... catalepsy). The Stanford, Harvard, HIP, and most other susceptibility scales convert numbers into an assessment of a person's ... catalepsy, regression to provable events in subjects' early lives and even into infantile reflexology. Erickson stated in his ... "; "catalepsy"; "ideomotor responsiveness"; "age regression"; "revivification"; "hyperamnesia"; "[automatic or suggested] ...
stupor: no psycho-motor activity; not actively relating to environment catalepsy: passive induction of a posture held against ... waxy flexibility/catalepsy, stereotypy (purposeless, repetitive movements), echolalia or echopraxia, verbigeration (repeat ... catalepsy; waxy flexibility; mutism; negativism; posturing; mannerisms; stereotypies; psychomotor agitation; grimacing; ...
On Catalepsy. Read before the medical section of the Manchester Royal Institution (Pamphlet). London: John Churchill & Sons. ...
Catalepsy often responds to Benzodiazepines (e.g., Lorazepam) in pill and I.V. form. Encephalitis is an inflammation of the ... Catalepsy is considered a symptom of serious diseases of the nervous system (e.g., Parkinson's disease, Epilepsy, etc.) rather ... Catalepsy is a nervous disorder characterized by immobility and muscular rigidity, along with a decreased sensitivity to pain. ... "What is Catalepsy? (with pictures)". wiseGEEK. "West Nile Virus". Medicinenet.com. Retrieved 2013-10-30. "How Serious Are ...
"CATALEPSY: 'Bleed' Video Released". Blabbermouth.net. June 7, 2011. Retrieved March 27, 2018. "Bury Your Dead Part Ways With ... He sang on "Chrono" on The Ghost Inside's album Returners and on the track "Goliath", on Catalepsy's album Bleed. More recently ...
Neither catalepsy or anything. The song is pure poetic fantasy and it was done on a regular day. I was living with Maria Rosa ... Is it true you wrote "Rasguña las Piedras" in honor of a girlfriend who had catalepsy?" "I have no idea who came up with that. ...
Examples include catalepsy, headache, epilepsy and nightmares. There also existed a demon of blindness, "Shabriri" (lit. " ...
Catalepsy is determined by the bar test. The mouse is placed on a bar oriented parallel to and approximately 1 inch off of the ... The four behavioral components of the tetrad are spontaneous activity, catalepsy, hypothermia, and analgesia. Common assays for ... catalepsy, hypothermia, and analgesia in rodents. Accordingly, all true "tetrad effects" are not observed following treatment ...
"Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?". Neuroscience Letters. 330 (3): 251-4. doi:10.1016/s0304- ... 4-Methylenedioxymethamphetamine counteracts akinesia enantioselectively in rat rotational behavior and catalepsy". Synapse. 55 ...
Dissociatives produce analgesia, amnesia and catalepsy at anesthetic doses. They also produce a sense of detachment from the ...
It is highly cryptic, using catalepsis. Santiago-Blay, JA; Maldonado-Capriles, J (1988). "Observations on the true bugs Emesa ...
His life crashes around him when he finds he suffers from catalepsy, an incurable condition marked by loss of voluntary motion ... Sirak, wants to find the medicine of catalepsy Tiberio Cruz .... Hercules - Arturo's ex-servant, in love with Margot. Villain, ...
Chiu S, Mishra RK (January 1979). "Antagonism of morphine-induced catalepsy by L-prolyl-L-leucyl-glycinamide". European Journal ...
Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (Feb 1999). "Attenuation of haloperidol-induced catalepsy by a 5-HT2C ...
Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (February 1999). "Attenuation of haloperidol-induced catalepsy by a 5- ...
In April 1652, Hatfield became ill with a type of catalepsy. She became paralyzed, blind, deaf and mute. This lasted for ...
"Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist". British Journal of Pharmacology. 126 (3): 572-4 ...
The longer you keep them in the state of catalepsy, the deeper they sink into the third state. I kept him for ten minutes in ... this state of catalepsy. He was in a state of extreme exhaustion. Sweat was on his face. Observing that even Bill [Sheriff ...
Charcot introduced three states of hypnosis: fatigue, catalepsy, and somnambulism, or sleepwalking; it was within this last ...
St Paul's Potion was intended to cure epilepsy, catalepsy and stomach problems. Many ingredients used in the potion had ...
Catalepsy (Narcolepsy). *Catatonia. *Catatonic schizophrenia. *Circadian rhythm sleep disorder. *Claustrophobia. *Clinical ...
Catalepsy had already self-funded recording an additional seven songs but, the time had passed, and the band members each went ... Catalepsy continued in the studios to record three more songs with Ross singing and writing "Under the Influence", "Who Can You ... In 1987, Hochheiser and Robinson formed Catalepsy with the Canadian vocalist Veronica Ross. With Ross, singing and recording ...
They are also used to cure people with seizure problems, epilepsy and catalepsy. Heat is also a property of Babalu-aye, like ...
A coroner's court was later told he had the nervous condition of catalepsy. The inquest jury - after considering several ...
Catalepsy Ungvari GS, Goggins W, Leung SK, Lee E, Gerevich J (February 2009). "Schizophrenia with prominent catatonic features ...
... as he was prone to catalepsy. The possibility of suicide was also considered. A finding of suicide would have had substantial ...
On the Curability of Certain Forms of Insanity, Epilepsy, Catalepsy, and Hysteria in Females. Robert Hardwicke, 1866. Atoki, ...
Like other types of stick insects they use crypsis and catalepsy to evade predators. Eurycantha calcarata typically reproduce ...
Madeline revives from her catalepsy, exits her coffin and returns to her shocked husband. Jean Debucourt as Roderick Usher ...
The effects of dissociatives can include sensory dissociation, hallucinations, mania, catalepsy, analgesia and amnesia. ...
Teresa endured intermittent attacks of catalepsy from then on. In the arts, catalepsy is often used for dramatic effect, ... such as catalepsy. St. Teresa of Avila experienced a prolonged bout of catalepsy that began in 1539. This episode was ... "Definition of Catalepsy". Sanberg PR, Bunsey MD, Giordano M, Norman AB (October 1988). "The catalepsy test: its ups and downs ... This is catalepsy!" In the second chapter of Álvares de Azevedos Noite na Taverna, character Solfieri rescues a woman who has ...
Catalepsy disbanded in 2013 but re-formed in September 2014 shortly. Catalepsy is now writing new material in 2021 for an ... Catalepsy at AllMusic Iniquity at AllMusic "Catalepsy Streaming New Track "Infernal"". Theprp.com. December 4, 2010. Official ... Catalepsy is an American deathcore band formed in 2004. They have released one EP, Godless, and two studio albums, Iniquity and ... Catalepsy was founded in 2004 as a thrash/metalcore three-piece. From August 2006 the bands sound moved towards deathcore. ...
This advanced hypnosis session will help you experience arm catalepsy in hypnosis, and more generally how hypnotic phenomena ... Catalepsy means becoming rigid, immobile and strong.. And as with all hypnotic phenomena catalepsy diminishes as trance ... What is happening with arm catalepsy in hypnosis?. During hypnotic phenomena such as arm catalepsy, the conscious mind sits ... Experience Arm Catalepsy in Hypnosis. Use this permissive, indirect hypnosis session to experience hypnotic phenomena ...
catalepsy: A condition characterized by lack of response to external stimuli and by muscular rigidity, so that the limbs remain ... If it is catalepsy he is suffering from, then it is a kind of catalepsy I never heard of. ... From cata- + -lepsy; ultimately from Ancient Greek κατάληψις (katalēpsis, "act of seizing"), from καταλαμβάνω (katalambanō, "I ... If a solar spectrum is suddenly brought into a dark room it may produce catalepsy, which is also produced by looking at the sun ...
Mice developped catalepsy after 3 weeks on the LCa/Mg diet. LCa/Mg diet-induced catalepsy was improved by the administration of ... The present study aimed to test the hypothesis that catalepsy, a behavioral immobility and one of the Parkinsonian symptoms, ... These results suggest that catalepsy in LCa/Mg mice might result from a hypofunction of dopaminergic neurons. Moreover, our ... DA receptor D2 agonist bromocriptine and the DA releaser amantadine were tested for their effects on the induced catalepsy. ...
... catalepsies explanation free. What is catalepsies? Meaning of catalepsies medical term. What does catalepsies mean? ... Looking for online definition of catalepsies in the Medical Dictionary? ... catalepsy. (redirected from catalepsies). Also found in: Dictionary, Thesaurus, Encyclopedia. catalepsy. [kat´ah-lep″se] a ... catalepsy. (kăt′l-ĕp′sē). n. pl. catalep·sies A condition characterized by lack of response to external stimuli and by muscular ...
As shown in Figure 1, acute administration of 40, 80, and 160 mg/kg EGb 761 did not induce catalepsy. Catalepsy time was ... induces catalepsy in a dose-dependent manner in mice (8). Furthermore, the acute effect of L-NOARG is additive with catalepsy ... 1988). The catalepsy test: its ups and downs. Behavioral Neuroscience, 102: 748-759. [ Links ]. 11. Chermat R, Brochet D, ... Catalepsy was considered to have ended when the forepaw touched the floor or when the mouse climbed the bar. Measurements were ...
... see Catalepsy (band)Catalepsy is a nervous condition characterized by muscular rigidity and fixity of posture regardless of ... Catalepsy. :This page is about the medical condition, for the deathcore band, see Catalepsy (band). Catalepsy is a nervous ... Catalepsy - Cat a*lep sy, ,,Catalepsis Cat a*lep sis, n. [NL. catalepsis, fr. Gr. ? a seizure, fr. ? to seize upon; kata down ... catalepsy - [kat′ə lep΄sē] n. [LL catalepsis < Gr katalēpsis, a seizing, grasping < katalambanein < kata , down + ...
Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy.. B Hitzemann, K Dains, S ... Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy.. B Hitzemann, K Dains, S ... Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy.. B Hitzemann, K Dains, S ... Previous data have suggested that the genetic variability in the sensitivity to haloperidol-induced catalepsy is associated ...
Compound was evaluated for inhibitory activity on haloperidol induced catalepsy (anti-cataleptic activity) in mice after ...
Relationship between mACh receptor occupancy and change in catalepsy was used as the measure of catalepsy-reducing effects of ... Prediction of Drug-Induced Catalepsy Based on Dopamine D1, D2, and Muscarinic Acetylcholine Receptor Occupancies. Kaori ... Intensities of catalepsy predicted with this dynamic model considering the interaction between D1 and D2 receptors ... Prediction of Drug-Induced Catalepsy Based on Dopamine D1, D2, and Muscarinic Acetylcholine Receptor Occupancies. Kaori ...
Morphine catatonia was more susceptible to inhibition by the amygdaloid lesions than the catalepsy/catatonia induced by the ... Therefore, in a attempt to differentiate the behavioural states termed catalepsy and catatonia, haloperidol and morphine were ... peromide and spiroxatrine catalepsy/catatonia. In contrast, morphine catatonia was only partially reduced by ablating the ... On catalepsy and catatonia and the predictability of the catalepsy test for neuroleptic activity. @article{Costall1974OnCA, ...
... - Cat a*lep sy, ,,Catalepsis Cat a*lep sis, n. [NL. catalepsis, fr. Gr. ? a seizure, fr. ? to seize upon; kata down ... Catalepsy - This page is about the medical condition, for the deathcore band, see Catalepsy (band)Catalepsy is a nervous ... catalepsy - [kat′ə lep΄sē] n. [LL catalepsis < Gr katalēpsis, a seizing, grasping < katalambanein < kata , down + ... catalepsy - n. rigid or trance like fit. ♦ cataleptic, a. ♦ cataleptiform, a. like catalepsy … Dictionary of difficult words ...
Be aware of portion sizes and use moderation when it comes to foods high in fat and sugar. If you do indulge, savor the food away from distractions like your phone. You may find you feel more satisfied and dont over-indulge.. ...
... which can include catalepsy and drug-induced parkinsonism (5). Haloperidol-induced catalepsy is thought to result from high ... Haloperidol-Induced Catalepsy.. Mice were injected with haloperidol (1.5 mg/kg i.p.) and returned to their home cage for 60 min ... Haloperidol-Induced Catalepsy Is Strongly Reduced in D32f/fD2RCre+ Mice.. First-generation antipsychotic drugs such as ... A and B) Mice were injected with 1.5 mg/kg haloperidol, and 60 min later catalepsy was assessed by measuring the latency until ...
Catalepsy in Insects. Experiments Showing how Insects Pass Periodically into a Trance ...
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CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion ... CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion ... Locomotor activity, vacuous chewing movements and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated ... Locomotor activity, vacuous chewing movements and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated ...
Hypothermia, catalepsy, and locked-in syndrome. One such condition is hypothermia, whereby the body experiences a sudden, ... Catalepsy and locked-in syndrome are examples of other conditions in which the living could be mistaken for dead. ... Catalepsy is characterized by a trance-like state, slowed breathing, reduced sensitivity, and complete immobility, which can ...
Traducción de catalepsy , The term atypical was originally used to describe drugs that in animal models predict antipsychotic ... A spokesperson for the cemetery told the newspaper: We want to be pioneers and avoid catalepsy cases, in which a person gets ... Stupor or catalepsy, mutism, posturing/grimacing/stereotypy, echolalia or echopraxia and excessive motor activity were the main ... Furthermore, high dose morphine is well reported as a cause of rigidity, catalepsy, akathisia, and myoclonus, which must add to ...
Catalepsy - Condition which causes Seizures/trances or unconsciousness. Catarrh - Inflammation of a mucous membrane, especially ... Ecstasy - A form of catalepsy characterixed by loss of reason. Edema - Nephrosis; swelling of tissues. see Dropsy. Edema of ...
Catalepsy.. Catalepsy was observed only at high doses of brexpiprazole and aripiprazole, with ED50 values of 20 and 42 mg/kg p. ... Catalepsy in Rats. Rats were fasted for 15 hours before administration of test compounds. Catalepsy was measured at 1, 2, 4, 6 ... Rats were forced to hang by their right forepaw on the upper edge of a steel can (diameter: 6 cm × height 10 cm). A catalepsy ... Brexpiprazole induced catalepsy (ED50 = 20) well above clinically relevant D2 receptor occupancies, suggesting a low risk for ...
Adolescent nicotine exposure is an increasing concern with the emergence of electronic cigarette devices (e.g. vaping), highlighting the importance of considering long-term behavioural consequences of adolescent exposure. Male Sprague-Dawley rats (n=16, 8/group) were treated daily with 1.0 mg/kg subcutaneous nicotine from post-natal days 28-42. Upon adulthood, rats underwent behavioural assessments: novel object preference as a measure of short- and long-term memory, conditioned avoidance response (CAR) as a measure of aversive behaviour acquisition and elevated plus maze as a measure of anxiety like behaviour. Adolescent nicotine-treated rats displayed a significant, but selective, impairment of short-term memory (5-minute delay). A significant within-animal delay by drug interaction (F(1,14)=4.748, p=0.047) was observed; between-group analyses showed that nicotine-treated animals displayed significantly decreased discrimination ratio compared to vehicle-treated animals (p=0.011). No group ...
Pertwee, R. G., & Wickens, A. P. (1991). Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or ... Pertwee, Roger Guy ; Wickens, A P . / Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or ... They also provide evidence that cannabinoids can produce catalepsy by interacting with tissue in the vicinity of the globus ... They also provide evidence that cannabinoids can produce catalepsy by interacting with tissue in the vicinity of the globus ...
... catalepsy). Catalepsy induced by neuroleptics in animals has been used as a model for the extrapyramidal side effects ... catalepsy). Catalepsy induced by neuroleptics in animals has been used as a model for the extrapyramidal side effects ... catalepsy). Catalepsy induced by neuroleptics in animals has been used as a model for the extrapyramidal side effects ... catalepsy). Catalepsy induced by neuroleptics in animals has been used as a model for the extrapyramidal side effects ...
Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity. Wouter Koek, James H. Woods, Kenner C. Rice, ... Phencyclidine-induced catalepsy in pigeons : Specificity and stereoselectivity. / Koek, Wouter; Woods, James H.; Rice, Kenner C ... Koek, W., Woods, J. H., Rice, K. C., Jacobson, A. E., Huguenin, P. N., & Burke, T. R. (1984). Phencyclidine-induced catalepsy ... Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity. European Journal of Pharmacology. 1984 Nov 27; ...
Catalepsy (Narcolepsy). *Catatonia. *Catatonic schizophrenia. *Circadian rhythm sleep disorder. *Claustrophobia. *Clinical ...
... catalepsy •Basie, Casey, Gracie, lacy, OCasey, pace, pacy, precis, racy, spacey, Stacey, Sulawesi, Tracy •cadency • ...
... and catalepsy. Her mobility had deteriorated, with selective speech, mute episodes, and poor oral intake noted by medical staff ...
Catalepsy.. Mind.--Excessive loquacity; exuberance of spirits. Time seems too long; seconds seem ages; a few rods an immense ...
  • however, these drugs are often associated with extrapyramidal side effects including catalepsy, manifested as extreme hypolocomotion and rigid immobility ( 5 ). (pnas.org)
  • After the treatments, the animals were submitted to behavioral evaluation using the catalepsy test. (scielo.br)
  • Here we show that mice lacking the enzyme fatty acid amide hydrolase (FAAH −/− ) are severely impaired in their ability to degrade anandamide and when treated with this compound, exhibit an array of intense CB 1 -dependent behavioral responses, including hypomotility, analgesia, catalepsy, and hypothermia. (pnas.org)
  • The present study aimed to test the hypothesis that catalepsy, behavioral immobility and a Parkinsonian symptom results from functionally impaired dopaminergic neurons in mice fed low amounts of Ca and Mg (LCa/Mg). A group of mice fed a LCa/Mg diet for 6 weeks was compared to a control group on a standard diet. (sigmaaldrich.com)
  • Catalepsy (from Ancient Greek katálēpsis, κατάληψις, "seizing, grasping") is a nervous condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain. (wikipedia.org)
  • catalepsy - ► NOUN ▪ a medical condition in which a person suffers a trance or seizure with a loss of sensation and consciousness accompanied by rigidity of the body. (academic.ru)
  • Furthermore, high dose morphine is well reported as a cause of rigidity, catalepsy, akathisia, and myoclonus, which must add to the difficulty of interpreting pain on the basis of observation alone. (oxforddictionaries.com)
  • Catalepsy, a symptom of Parkinson's disease, epilepsy and other conditions and disorders affecting the central nervous system, causes rigidity of the muscles and slowing of the heart and respiration. (mentalfloss.com)
  • Catalepsy is marked by severe muscular rigidity and fixity of posture regardless of external stimuli. (eurekalert.org)
  • Catalepsy is a nervous disorder characterized by immobility and muscular rigidity, along with a decreased sensitivity to pain. (reference.com)
  • In the present study, we have attempted to evaluate the protective effect of Triphala on haloperidol induced catalepsy in mice. (elsevier.com)
  • Pretreatment of Triphala decreased haloperidol induced catalepsy in mice, which is comparable to that produced by the standard drug scopolamine. (elsevier.com)
  • Objective: In the present study, we evaluated the anticataleptic efficacy of Vitex negundo, a polyherbal formulation in haloperidol induced catalepsy in mice.Methods: Five groups (n=6) of male albino mice were used in the study. (who.int)
  • roots showed maximum cataleptic score 12.34�78, 14.43�43 and 15.43�67 min, respectively at 120 minutes in haloperidol treated animals.Conclusions: The present study indicates that the methanolic extract of Vitex negundo reduces haloperidol-induced catalepsy in mice. (who.int)
  • In the present study, we evaluated whether the ovarian sex hormones are involved in the cannabinoid-induced catalepsy and analgesia in ovarectomized (OVX) female mice. (biomedcentral.com)
  • 0.05) on catalepsy or analgesia induced by low dose WIN 55,212-2 in OVX mice. (biomedcentral.com)
  • The present data demonstrated for the first time that ovarian female hormone progesterone is involved in both cannabinoid-induced catalepsy and analgesia in female mice. (biomedcentral.com)
  • Haloperidol and NECA-induced mice pre-treated with PTTP at 10mg/kg showed attenuation in catalepsy and akinesia without significant neurotoxicity in rotarod test at 20mg/kg. (curehunter.com)
  • ASP5854 ameliorated A(2A) agonist 2-[p-(2-carboxyethyl) phenethylamino]-5'-N-ethylcarboxamidoadenosine (CGS21680)- and haloperidol-induced catalepsy in mice, with the minimum effective doses of 0.32 and 0.1 mg/kg, respectively, and it also improved haloperidol-induced catalepsy in rats at doses higher than 0.1 mg/kg. (curehunter.com)
  • Indeed, in mouse studies, the Borrelli team discovered that removing D2 receptors in nerve cells (cholinergic interneurons) did not result in catalepsy in the mice upon antipsychotic treatment. (eurekalert.org)
  • The mice developed catalepsy after 3 weeks on the LCa/Mg diet. (sigmaaldrich.com)
  • These results suggest that catalepsy in LCa/Mg mice results from hypofunction of the dopaminergic neurons. (sigmaaldrich.com)
  • Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most which are mediated by CB1 receptors. (biomedcentral.com)
  • Both the catalepsy and analgesia induced by different doses of synthetic cannabinoid WIN 55,212-2 (2 and 4 mg/kg, i.p.) were examined in three groups in the presence or absence of the CB1 antagonist AM251. (biomedcentral.com)
  • We also evaluated effects of estradiol and progesterone on catalepsy and analgesia induced by WIN 55,212-2 in OVX group. (biomedcentral.com)
  • Pretreatment with estradiol caused no effect on cannabinoid-induced catalepsy or analgesia in OVX group. (biomedcentral.com)
  • Dissociatives produce analgesia, amnesia and catalepsy at anesthetic doses. (wikipedia.org)
  • L G -nitro-arginine (L-NOARG), a nitric oxide synthase inhibitor, and haloperidol, a drug that blocks dopamine receptors, are both known to induce catalepsy in rodents. (scielo.br)
  • Atypicality' was initially defined as the inability to induce catalepsy in laboratory animals (as the old, 'typical', conventional agents can do). (oxforddictionaries.com)
  • Compound 16 not only failed to induce catalepsy in the rat but was quite effective in reversing the cataleptic effect of neuroleptic agents, thus indicating a low propensity for causing extrapyramidal side effects. (nih.gov)
  • Suggested or induced rigid catalepsy, of extended limbs or even the entire body, sometimes tested with heavy weights, has been a staple of stage hypnosis shows and even academic demonstrations of hypnotism since the late 18th century, as proof of extraordinary physical abilities possible in trance states. (wikipedia.org)
  • Catalepsy means becoming rigid, immobile and strong. (hypnosisdownloads.com)
  • Catalepsy is also a term used by hypnotists to refer to the state of making a hypnotised subject's arm, leg or back rigid. (academic.ru)
  • catalepsy - n. rigid or trance like fit. (academic.ru)
  • Admittedly, he suffers from a strange illness which doctors merely call catalepsy, when the muscles become stiff and rigid. (oxforddictionaries.com)
  • Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy. (aspetjournals.org)
  • Previous data have suggested that the genetic variability in the sensitivity to haloperidol-induced catalepsy is associated with the number of dopamine neurons in the substantia nigra zona compacta (SNZc). (aspetjournals.org)
  • In this study, the relationship between in vivo dopamine D 1 and D 2 receptor occupancies and catalepsy was investigated to predict the intensity of catalepsy induced by drugs that bind to D 1 and D 2 receptors nonselectively. (aspetjournals.org)
  • To examine the validity of this model, catalepsy and in vivo dopamine receptor occupancy were measured after administration of drugs that induce or have a possibility to induce parkinsonism (haloperidol, flunarizine, manidipine, oxatomide, hydroxyzine, meclizine, and homochlorcyclizine). (aspetjournals.org)
  • The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with the neuroleptic for the postsynaptic striatal dopamine receptor sites with resultant potentiation of the neuroleptic-induced catalepsy. (who.int)
  • It was studied in two independent experiments: (i) penetration of 3 H-labeled dopamine from its mixture with 10 −5 M H 2 O 2 into hypothalamus and striatum structures of intact rat brain, and (ii) effect of unlabeled dopamine from a mixture with H2O2 on the rat motor activity in a haloperidol catalepsy model. (chemweb.com)
  • It was shown that (i) at the third minute after nasal application of the dopamine + H 2 O 2 mixture, the dopamine level increases 45-fold in the hypothalamus and almost 30-fold in the striatum and (ii) motility of animals in the catalepsy haloperidol model is recovered 90 sec after intranasal introduction of dopamine. (chemweb.com)
  • The anti-parkinsonian drugs dopamine (DA) precursor L-3,4-dihydroxy phenylamine (L-DOPA), the selective DA receptor D(2) agonist bromocriptine, and the DA releaser amantadine were tested for their effects on induced catalepsy. (sigmaaldrich.com)
  • Stupor or catalepsy, mutism, posturing/grimacing/stereotypy, echolalia or echopraxia and excessive motor activity were the main catatonic features. (oxforddictionaries.com)
  • A patient with catalepsy is said to be in a catatonic state. (groundreport.com)
  • Is catalepsy in schizophrenia always followed with catatonic stupor? (steadyhealth.com)
  • Catatonic (rare) - Symptoms: withdrawal & catalepsy. (bartleby.com)
  • Pertwee, RG & Wickens, AP 1991, ' Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoids ', Neuropharmacology , vol. 30, no. 3, pp. 237-244. (elsevier.com)
  • Field E.F., Whishaw I.Q., Pellis S.M.: Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats. (biomedcentral.com)
  • Findings One to 7-day treatment with estrogen had a protective effect on haloperidol-induced extrapyramidal disorders such that it significantly improved catalepsy and motor impairment in the rats and restored and normalized their motor levels. (jogcr.com)
  • As expected, reserpinetreated rats showed progressively increased duration of catalepsy together with short-term memory deficits in the object recognition test. (omicsonline.org)
  • showed in rats that the reduction of neuroleptic-induced catalepsy by ritanserin was independent of changes in DA dynamics suggesting that the anti-cataleptic effects of ritanserin may involve non-dopaminergic targets, possibly glutamatergic. (frontiersin.org)
  • The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment classified as haloperidol-induced extrapyramidal disorders. (jogcr.com)
  • Sabahi M, Amiahmadi S, Haddadi R. Effects of Estrogen and Progesterone on Catalepsy and Motor and Balance Impairment Classified as Haloperidol-induced Extrapyramidal Disorders. (jogcr.com)
  • The neuroleptic agents peromide and spiroxatrine induced an immobility in the rat which, in appearance, more resembled morphine catatonia than haloperidol catalepsy. (semanticscholar.org)
  • Therefore, in a attempt to differentiate the behavioural states termed catalepsy and catatonia, haloperidol and morphine were closely compared using drug interaction and brain lesion studies. (semanticscholar.org)
  • Since the catalepsy test has predictive value regarding extrapyramidal effects, the possibility of pharmacological interactions between haloperidol and Ginkgo biloba extracts should be further investigated in clinical studies. (scielo.br)
  • Brexpiprazole induced catalepsy (ED 50 = 20) well above clinically relevant D 2 receptor occupancies, suggesting a low risk for extrapyramidal side effects. (aspetjournals.org)
  • Neuroleptics that are commonly used in the treatment of schizophrenia and other affective disorders are often associated with distressing extrapyramidal side effects (catalepsy). (elsevier.com)
  • Catalepsy induced by neuroleptics in animals has been used as a model for the extrapyramidal side effects associated with antipsychotic agents in human beings. (elsevier.com)
  • Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. (who.int)
  • Catalepsy is an American deathcore band formed in 2004. (wikipedia.org)
  • It acts in a peculiar manner upon the nervous centers, occasioning that strange condition of the nervous system called catalepsy , in which the limbs of the unconscious patient remain stationary in whatever position they may be placed. (wordnik.com)
  • Catalepsy is also a characteristic symptom of cocaine withdrawal, and of schizophrenia treatment with typical anti-psychotics. (academic.ru)
  • Catalepsy - The state of persisting in unusual postures or facial expressions, regardless of outside stimuli, as is seen in schizophrenia and some other diseases of the nervous system. (academic.ru)
  • On examination she presented with waxy flexibility, negativism, new onset increased tone of her left arm, posturing, and catalepsy. (medscape.com)
  • Download Experience Arm Catalepsy in hypnosis now and start to unlock your hypnotic potential. (hypnosisdownloads.com)
  • Due to its advanced nature, Experience Arm Catalepsy is recommended only for practicing hypnotherapists or those experienced in using hypnosis. (hypnosisdownloads.com)
  • catalepsy - cataleptic, adj. (academic.ru)
  • The degree of catalepsy (cataleptic score) was measured as the time the animal maintained an imposed posture. (who.int)
  • Catalepsy is a symptom of certain nervous disorders or conditions such as Parkinson's disease and epilepsy. (wikipedia.org)
  • Catalepsy is considered a symptom of serious diseases of the nervous system (e.g. (reference.com)
  • And hypnotic phenomena, such as arm catalepsy, are an excellent way to discover and explore the conscious / unconscious split. (hypnosisdownloads.com)
  • And as with all hypnotic phenomena catalepsy diminishes as trance lightens, then disappears once you come out of trance. (hypnosisdownloads.com)
  • During hypnotic phenomena such as arm catalepsy, the conscious mind 'sits back' and observe what the unconscious mind is doing. (hypnosisdownloads.com)
  • The term 'atypical' was originally used to describe drugs that in animal models predict antipsychotic effects but do not produce catalepsy, most notably clozapine. (oxforddictionaries.com)
  • The hysterics' observable disorders, such as catalepsy, as well as their visual experiences, including hallucination and delirium, were deemed manifest content and, as such, not to be taken at face value. (oxforddictionaries.com)
  • CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion - induced by reserpine. (frontiersin.org)
  • The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. (hindawi.com)
  • They also provide evidence that cannabinoids can produce catalepsy by interacting with tissue in the vicinity of the globus pallidus and that the ability to interact in this way depends on the conformation of the cannabinoid molecule. (elsevier.com)
  • Unsuggested waxy catalepsy, sometimes accompanied by spontaneous anesthesia, is seen as an indicator of hypnotic trance. (wikipedia.org)
  • Arm catalepsy" is often a pre-hypnotic test performed prior to an induction into a full trance. (academic.ru)
  • Catalepsy , or being in a trance-like state. (medicalnewstoday.com)
  • Because muscarinic acetylcholine (mACh) receptor antagonists inhibit the induction of catalepsy, the anticholinergic activities of the drugs were investigated. (aspetjournals.org)
  • In Edgar Allan Poe 's " The Premature Burial ," the narrator suffers from catalepsy. (academic.ru)
  • It is known that catalepsy serves as an experimental animal model of parkinsonism. (aspetjournals.org)
  • Blockade of D2 receptor in these neurons increases neurotransmitter signaling (acetylcholine) above threshold on neighbor neurons leading to motor abnormalities in rodents (catalepsy) and in humans (parkinsonism). (eurekalert.org)
  • Acute treatment with 80 mg/kg EGb did not modify the catalepsy induced by L-NOARG but, the dose of 40 mg/kg significantly enhanced haloperidol-induced catalepsy measured at the 10th min of the test. (scielo.br)
  • Methanolic extract of Vitex negundo (50, 100, 200 mg/kg, i.p.) significantly potentiated haloperidol induced catalepsy at each time interval, in a dose dependent manner. (who.int)
  • The effects of estrogen and progesterone on haloperidol-induced catalepsy and motor impairment were assessed by a bar test and a rotarod performance test, respectively. (jogcr.com)
  • Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. (frontiersin.org)
  • Aims Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of stimuli. (jogcr.com)
  • Neuroleptic and non-neuroleptic catalepsy. (semanticscholar.org)
  • Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of rat brain. (semanticscholar.org)
  • Cholinergic- and neuroleptic-induced catalepsy: modification by lesions in the caudate-putamen. (semanticscholar.org)
  • IMSEAR at SEARO: Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat. (who.int)
  • If a solar spectrum is suddenly brought into a dark room it may produce catalepsy , which is also produced by looking at the sun, or a lime light, or an electric light. (wordnik.com)
  • In conclusion, the dynamic model considering D 1 , D 2 , and mACh receptor occupancies and synergism between D 1 and D 2 receptors may be useful for quantitative prediction of drug-induced catalepsy. (aspetjournals.org)
  • In some cases acute mania and convulsive attacks have been developed and in the natives of India catalepsy has been observed. (hpathy.com)
  • Catalepsy was determined by the standard bar test after 30 minutes of haloperidol administration and was scored as described by Ahtee and Benumbe. (elsevier.com)
  • The magicians of Egypt in modern times have been long celebrated adepts in charming serpents, and particularly by pressing the nape of the neck, they throw them into a kind of catalepsy , which renders them stiff and immovable -- thus seeming to change them into a rod. (wordnik.com)
  • Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and α-dioxadrol. (uthscsa.edu)
  • Relationship between mACh receptor occupancy and change in catalepsy was used as the measure of catalepsy-reducing effects of the drugs. (aspetjournals.org)
  • The co-administration of flutamide significantly reduced the protective effect of estrogen on catalepsy and motor balance impairment induced by haloperidol. (jogcr.com)
  • In Alexandre Dumas, père's novel The Count of Monte Cristo, the Abbé Faria has fits of catalepsy from time to time, before eventually dying from one. (wikipedia.org)
  • Auntie's piety was not of the niggerish kind, even Zoe, "The Octoroon," or any other woman or man in whose veins courses the blood of Ham four times diluted, knows that I mean it was not that glory-hallelujah variety of cunning or delusion, compounded of laziness and catalepsy , which is popular among the shouting, shirt-tearing sects of plantation darkies, who "git relijin" and fits twelve times a year. (wordnik.com)
  • In Alexandre Dumas, père 's novel " The Count of Monte Cristo ", the Abbé Faria suffered from fits of catalepsy from time to time. (academic.ru)