Catalepsy: A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)Dopamine Antagonists: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Thioxanthenes: Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.Flupenthixol: A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)Biperiden: A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.Clozapine: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.Stereotyped Behavior: Relatively invariant mode of behavior elicited or determined by a particular situation; may be verbal, postural, or expressive.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Serotonin 5-HT1 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.Anti-Dyskinesia Agents: Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias.Aprindine: A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.Phenmetrazine: A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.Dopamine Agonists: Drugs that bind to and activate dopamine receptors.Neurotensin: A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.Butyrophenones: Compounds containing phenyl-1-butanone.Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.Behavior, Animal: The observable response an animal makes to any situation.Receptors, Neurotensin: Cell surface proteins that bind neurotensin with high affinity and trigger intracellular changes which influence the behavior of cells. Neurotensin and neurotensin receptors are found in the central nervous system and in the periphery.Maternal-Fetal Relations: The bond or lack thereof between a pregnant woman and her FETUS.Raclopride: A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.Serotonin 5-HT1 Receptor Antagonists: Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.

Synergistic interactions between ampakines and antipsychotic drugs. (1/188)

Tests were made for interactions between antipsychotic drugs and compounds that enhance synaptic currents mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors ("ampakines"). Typical and atypical antipsychotic drugs decreased methamphetamine-induced hyperactivity in rats; the effects of near or even subthreshold doses of the antipsychotics were greatly enhanced by the ampakines. Interactions between the ampakine CX516 and low doses of different antipsychotics were generally additive and often synergistic. The ampakine did not exacerbate neuroleptic-induced catalepsy, indicating that the interaction between the different pharmacological classes was selective. These results suggest that positive modulators of cortical glutamatergic systems may be useful adjuncts in treating schizophrenia.  (+info)

Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. (2/188)

Atypical neuroleptics produce fewer extrapyramidal side-effects (EPS) than typical neuroleptics. The pharmacological profile of atypical neuroleptics is that they have equivalent or higher antagonist affinity for 5-HT2 than for dopamine D2 receptors. Our aim was to identify which 5-HT2 receptor contributed to the atypical profile. Catalepsy was defined as rats remaining immobile over a horizontal metal bar for at least 30 s, 90 min after dosing. Radioligand binding assays were carried out with homogenates of human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors expressed in Human Embryo Kidney (HEK293) cells. Haloperidol (1.13 mg kg(-1) i.p.) induced catalepsy in all experiments. The selective 5-HT2C/2B receptor antagonist, SB-228357 (0.32-10 mg kg(-1) p.o.) significantly reversed haloperidol-induced catalepsy whereas the 5-HT2A and 5-HT2B receptor antagonists, MDL-100907 (0.003-0.1 mg kg(-1) p.o.) and SB-215505 (0.1-3.2 mg kg(-1) p.o.) respectively did not reverse haloperidol-induced catalepsy. The data suggest a role for 5-HT2C receptors in the anticataleptic action of SB-228357.  (+info)

In vivo effects of new inhibitors of catechol-O-methyl transferase. (3/188)

1. The effects of two new synthetic compounds showing in vitro catechol-O-methyl transferase (COMT) inhibitor properties were studied in vivo and compared with the effects of nitecapone and Ro-41-0960. 2. QO IA (3-(3-hydroxy-4-methoxy-5-nitrobenzylidene)-2,4-pentanedione), QO IIR ([2-(3,4-dihydroxy-2-nitrophenyl)vinyl]phenyl ketone), nitecapone and Ro-41-0960 (30 mg kg(-1), i.p.) were given to reserpinized rats 1 h before the administration of L-DOPA/carbidopa (LD/CD, 50:50 mg kg(-1), i.p.). Locomotor activity was assessed 1 h later. All the COMT inhibitors (COMTI), with the exception of QO IA, markedly potentiated LD/CD reversal of reserpine-induced akinesia. Similar results were obtained when the COMTI were coadministered with LD/CD. The effect of compound QO IIR was dose-dependent (7.5-30 mg kg(-1), i.p.). 3. The COMTI (30 mg kg(-1), i.p.) potentiated LD/CD reversal of both catalepsy and hypothermia of reserpinized mice. 4. QO IIR, nitecapone and Ro-41-0960 (30 mg kg(-1), i.p.) reduced striatal 3-methyl-DOPA (3-OMD) levels and increased dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) levels. Compound QO IA was devoid of any effect on striatal amine levels. In contrast to the other inhibitors, Ro-41-0961 reduced HVA levels as well. The effect of QO IIR on striatal amine levels was dose-dependent (7.5-60 mg kg(-1), i.p.) 5. These results suggest that the new compound QO IIR is an effective peripherally acting COMT inhibitor in vivo.  (+info)

Effects of rubidium on behavioral responses to methamphetamine and tetrabenazine. (4/188)

Different groups of mice were injected subcutaneously every other day with rubidium chloride at three doses (0.41(50), 1.23(150) and 3.69(450) meq/kg (mg/kg)) or with saline as a control for a period of 2-3 weeks. Rubidium administered acutely did not affect spontaneous locomotor activities, while it tended to increase the activities when administered repeatedly though the increase was not statistically significant. The methamphetamine-induced hyperlocomotor activities were potentiated in the rubidium groups as compared with those in the saline group, this effect of ribidium being increased with prolongation of repeated administrations. Monotonic decreases in ambulation after tetrabenazine were not significantly affected in the rubidium-treated animals though the decreases were sometimes preceded by slight increases and recovery from the decrement tended to be more rapid. After tetrabenazine in the rubidium-treated groups, incidences of catalepsy were increased and jumping behavior and Straub tail responses occurred in a few cases. The results suggest that rubidium potentiates the excitatory action of methamphetamine on spontaneous locomotor activities, as contrasted with inhibitory influence of lithium.  (+info)

Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14. (5/188)

Previous studies have established that neuroleptic-induced catalepsy in mice is a highly heritable trait. The current study focuses on the detection of quantitative trait loci (QTL) for haloperidol-induced catalepsy in a BALB/cJ x LP/J F(2) intercross. One thousand thirty-seven F(2) animals were phenotyped and divided into four categories: very responsive (RR), responsive, nonresponsive, and very nonresponsive (NN). The RR and NN phenotypes comprised approximately 18% each of the total and differed in their haloperidol sensitivity by >10-fold. Sex differed significantly between the NN and RR groups (chi(2) = 14.0; p <.0002); females comprised 58% of the RR individuals but only 38% of the NN individuals. The difference between the extreme phenotypes in the number of piebald animals was highly significant (chi(2) = 30, p <. 00001). Eight percent of the RR individuals were piebald compared with 30% of the NN individuals. A genome wide scan confirmed the presence of a QTL (peak LOD = 6.4) on chromosome 14 near the piebald (Ednrb) and 5-hydroxytryptamine(2A) (Htr2a) loci. Although the parental BALB/cJ and LP/J strains differed significantly in striatal 5-hydroxytryptamine(2A) receptor binding, no marked differences were detected between the phenotypic extremes. A second QTL was detected on chromosome 14 (peak LOD = 6.9), which was located more proximally and included the Chat locus. No QTLs were detected on chromosomes 1 and 9, thus differentiating this cross from previous results obtained for a C57BL/6J x DBA/2J intercross.  (+info)

Enhanced cortical dopamine output and antipsychotic-like effects of raclopride by alpha2 adrenoceptor blockade. (6/188)

Clozapine exerts superior clinical efficacy and markedly enhances cortical dopamine output compared with classical antipsychotic drugs. Here the alpha2 adrenoceptor antagonist idazoxan was administered to rats alone or in combination with the D2/3 dopamine receptor antagonist raclopride. Dopamine efflux in the medial prefrontal cortex and conditioned avoidance responding were analyzed. Idazoxan selectively potentiated the cortical output of dopamine and augmented the suppression of conditioned avoidance responding induced by raclopride. These results challenge basic assumptions underlying the dopamine hypothesis of schizophrenia and provide insight into clozapine's mode of action.  (+info)

Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice. (7/188)

The cataleptic behavior induced by the dopamine D1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the "repeated measures effect," a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D1 antagonists. In this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This "injection-conditioned catalepsy" was also observed after repeated treatment with the dopamine D2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect.  (+info)

Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. (8/188)

Acute blockade of dopamine D(2) receptors by the typical antipsychotic drug haloperidol leads to alterations in neuronal gene expression and behavior. In the dorsolateral striatum, the levels of mRNA for the immediate-early gene c-fos and the neuropeptide gene neurotensin/neuromedin N (NT/N) are significantly increased by haloperidol. An acute behavioral response to haloperidol is catalepsy, considered to be a rodent correlate of some of the immediate extrapyramidal motor side effects seen in humans. Several lines of evidence suggest a link between neurotensin induction in the dorsolateral striatum and catalepsy. We hypothesize that both striatal gene induction and catalepsy elicited by haloperidol arise from the combined effect of excitatory adenosinergic and glutamatergic inputs acting at adenosine A(2A) and N-methyl-D-aspartate (NMDA) receptors, respectively. In agreement with our previous reports, adenosine antagonists reduced haloperidol-induced c-fos and neurotensin gene expression as well as catalepsy. In agreement with other reports, the noncompetitive NMDA receptor antagonist MK-801 also reduced gene expression and catalepsy in response to haloperidol. The competitive NMDA receptor antagonist LY235959 decreased haloperidol-induced catalepsy. We show here that blocking both A(2A) and NMDA receptors simultaneously in conjunction with haloperidol resulted in a combined effect on gene expression and behavior that was greater than that for block of either receptor alone. Both c-fos and NT/N mRNA levels were reduced, and catalepsy was completely abolished. These results indicate that the haloperidol-induced increases in c-fos and NT gene expression in the dorsolateral striatum and catalepsy are driven largely by adenosine and glutamatergic inputs acting at A(2A) and NMDA receptors.  (+info)

*Catalepsy (band)

Catalepsy is an American deathcore band formed in 2004. They have released one EP, Godless, and two studio albums, Iniquity and ... Catalepsy was founded in 2004 as a thrash/metalcore three-piece. From August 2006 the band's sound moved towards deathcore. ... He was replaced by Rick Norman, formerly of In The Ruins, also a past member of Catalepsy. On December 3, 2010, the band ... Catalepsy disbanded in 2013 but re-formed in September 2014. Current lineup Andrew Carothers - vocals (2007-2008, 2010, 2014- ...

*Confesiones de Invierno

Neither catalepsy or anything. The song is pure poetic fantasy and it was done on a regular day. I was living with Maria Rosa ... Is it true you wrote "Rasguña las Piedras" in honor of a girlfriend who had catalepsy?" "I have no idea who came up with that. ...

*Demon

Examples include catalepsy, headache, epilepsy and nightmares. There also existed a demon of blindness, "Shabriri" (lit. " ...

*Tetrad test

Catalepsy is determined by the bar test. The mouse is placed on a bar oriented parallel to and approximately 1 inch off of the ... The four behavioral components of the tetrad are spontaneous activity, catalepsy, hypothermia, and analgesia. Common assays for ... catalepsy, hypothermia, and analgesia in rodents. Accordingly, all true "tetrad effects" are not observed following treatment ...

*UWA-101

"Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?". Neuroscience Letters. 330 (3): 251-4. doi:10.1016/s0304- ... 4-Methylenedioxymethamphetamine counteracts akinesia enantioselectively in rat rotational behavior and catalepsy". Synapse. 55 ...

*Hallucinogen

Dissociatives produce analgesia, amnesia and catalepsy at anesthetic doses. They also produce a sense of detachment from the ...

*Ghilianella borincana

It is highly cryptic, using catalepsis. Santiago-Blay, JA; Maldonado-Capriles, J (1988). "Observations on the true bugs Emesa ...

*Nuciferine

It induces sedation, hypothermia, ptosis, and (in higher doses) catalepsy; it inhibits spontaneous motor activity, conditioned ...

*Melanocyte-inhibiting factor

Chiu S, Mishra RK (January 1979). "Antagonism of morphine-induced catalepsy by L-prolyl-L-leucyl-glycinamide". European Journal ...

*5-HT2B receptor

Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (Feb 1999). "Attenuation of haloperidol-induced catalepsy by a 5-HT2C ...

*SB-215505

Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (February 1999). "Attenuation of haloperidol-induced catalepsy by a 5- ...

*Martha Hatfield

In April 1652, Hatfield became ill with a type of catalepsy. She became paralyzed, blind, deaf and mute. This lasted for ...

*La traición

His life crashes around him when he finds he suffers from catalepsy, an incurable condition marked by loss of voluntary motion ... Sergio Gonzalez .... Doctor Max - killed Daniel's father to find the cure to catalepsy. Tiberio Cruz .... Hercules - Arturo's ...

*Glossary of psychiatry

Catalepsy is the term for catatonic rigidity of the limbs which often results in abnormal posturing for long intervals. ... Catatonia involves a significant psychomotor disturbance, which can occur as catalepsy, stupor. excessive purposeless motor ...

*Henry Byng, 4th Earl of Strafford

A coroner's court was later told he had the nervous condition of catalepsy. The inquest jury - after considering several ...

*Dissociative

The characteristic features of dissociative anesthesia were described as catalepsy, amnesia and analgesia. According to Pender ... The effects of dissociatives can include sensory dissociation, hallucinations, mania, catalepsy, analgesia and amnesia. ...

*Waxy flexibility

Catalepsy Ungvari GS, Goggins W, Leung SK, Lee E, Gerevich J (February 2009). "Schizophrenia with prominent catatonic features ...

*Clitoridectomy

On the Curability of Certain Forms of Insanity, Epilepsy, Catalepsy, and Hysteria in Females. Robert Hardwicke, 1866. Atoki, ...

*Eurycantha calcarata

Like other types of stick insects they use crypsis and catalepsy to evade predators. E. calcarata typically reproduce through ...

*William A. Hammond

He explained the behavior of mediums as symptoms of hypnosis, hysteria, catalepsy and ectasy. His book The Physics and ...

*Meclizine

... also is a dopamine antagonist at D1-like and D2-like receptors[citation needed], but does not cause catalepsy in mice ... "Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies". Drug ...

*Detente (band)

In 1987 Detente reformed under the name of Catalepsy with vocalist Veronica Ross from Canada. With Veronica writing the lyrics ...

*Homochlorcyclizine

dead link] Haraguchi K, Ito K, Kotaki H, Sawada Y, Iga T (June 1997). "Prediction of drug-induced catalepsy based on dopamine ...

*Trance

These involuntary experiences include uncontrolled bodily movements (fits, bodily exercises, falling as dead, catalepsy, ...

*NMDA receptor antagonist

... s induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. Ketamine ...
Uridine (15mg/kg/day, i.p.), haloperidol (1mg/kg/day, i.p.), uridine (15mg/kg/day, i.p.) plus haloperidol (1mg/kg/day, i.p.) or saline have been chronically administered to Sprague-Dawley male rats. Following 1 week of wash-out, the effects of these treatments on basal striatal dopamine (DA) release as well as on the DA release induced by an acute haloperidol challenge (2mg/kg, i.p.) were studied by means of intracerebral microdialysis. Behavioural tests such as haloperidol-induced catalepsy or apomorphine-induced stereotypics were also performed 4-7 days after drug withdrawal. The chronic treatment with uridine alone or associated with haloperidol markedly reduced DA release induced by an acute haloperidol challenge. The behavioural studies also indicated a change in DA-related behaviours in these conditions. The animals chronically treated with uridine showed significant increases in the stereotypy scores and in the catalepsy induced by an acute haloperidol challenge with respect to saline ...
Most behavioral, physiological and cellular effects of theneurotransmitter dopamine require concomitant activation of both D1 and D2 receptors, a phenomenon referred to as D1/D2 synergism. Since D1 and D2 receptors are located mostly on separate neurons, and since D1/D2 synergism occurs in the absence of action potentials, we have suggested that electrotonic coupling via gap junctions plays an important role in this phenomenon. A major constituent of gap junctions is connexin36 (Cx36), a protein that is abundant in neurons. The role Cx36 in D1/D2 synergism, as manifested behaviorally, was studied here in mice genetically engineered to express normal, reduced, or undetectable amounts of this protein. The results show that D1/D2 synergism and its breakdown were not affected by the presence or absence of Cx36. Unexpectedly, it was observed that the absence of Cx36 leads to resistance to the cataleptic effects of reserpine in a gene dosage-dependent manner.
Traducción de catalepsy | The term atypical was originally used to describe drugs that in animal models predict antipsychotic effects but do not
Noradrenergic involvement in dopamine-dependent stereotyped and cataleptic responses in the rat.: Two animal models were used to investigate the effect of lower
Populations from the Kii peninsula of Japan and Guam present a high incidence of amyotrophic lateral sclerosis and parkinsonism-dementia complex. It is thought that the low levels of calcium (Ca) and magnesium (Mg) in the drinking water are involved in the pathogenesis of these diseases. The present study aimed to test the hypothesis that catalepsy, a behavioral immobility and one of the Parkinsonian symptoms, may result from functionally impaired dopaminergic neurons in low Ca and Mg (LCa/Mg) fed mice. A group of mice fed with an LCa/Mg diet for 6 weeks was compared to a control group on a standard diet. Cataleptic symptoms such as akinesia and rigidity were measured using the bar test. The antiparkinsonian drugs dopamine (DA) precursor L-3, 4-dihydroxy phenylamine (L-DOPA), the selective DA receptor D2 agonist bromocriptine and the DA releaser amantadine were tested for their effects on the induced catalepsy. Mice developped catalepsy after 3 weeks on the LCa/Mg diet. LCa/Mg diet-induced catalepsy was
Dysphagia induces aspiration and causes aspiration pneumonia. There is no treatment for dysphagia fundamentally. Haloperidol reportedly induces dysphagia. In the present study, we established a haloperidol-induced dysphagia model in guinea pigs, and evaluated the effects of ginger, kikyoto, and a mixture of ginger and kikyoto on swallowing. Swallowing ability was evaluated using behavioral tests, computed tomography (CT), and videofluoroscopic examination of swallowing. To investigate the effect of ginger and kikyoto on swallowing, ginger, kikyoto, or a mixture of ginger and kikyoto was administered orally to guinea pigs with haloperidol-induced dysphagia. Effects of these compounds were evaluated with behavioral tests. Chronic administration of haloperidol reduced the number of swallows, as evaluated by the behavioral test and videofluoroscopic examination of swallowing. In our model, these compounds improved swallowing dysfunction. Our results suggest that this model might be useful in revealing the
EEG was registered in healthy volunteers before and after their entry into modeling (hypnotic) catalepsy. The brain activity recorded under standard electrode placement (the 10-20 international classification) was processed using a special computer program. The data obtained were digitally represented as sets of standard parameters of EEG patterns in 0,5-32 Hz diapason (alpha-, beta1-, beta2,-, theta-, delta-rythms). These parameters were compared under different functional tests particularly connected with the control of sensomotor brain activity ...
This letter interested me deeply, because the chief difficulty in the study of catalepsy is the rareness of the disease. You may believe, then, that I was in my consulting-room when, at the appointed hour, the page showed in the patient.. "He was an elderly man, thin, demure, and commonplace - by no means the conception one forms of a Russian nobleman. I was much more struck by the appearance of his companion. This was a tall young man, surprisingly handsome, with a dark, fierce face, and the limbs and chest of a Hercules. He had his hand under the others arm as they entered, and helped him to a chair with a tenderness which one would hardly have expected from his appearance.. "You will excuse my coming in, Doctor, said he to me, speaking English with a slight lisp. This is my father, and his health is a matter of the most overwhelming importance to me.. "I was touched by this filial anxiety. You would, perhaps, care to remain during the consultation? said I.. "Not for the world, he ...
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Looking for online definition of Extrapyramidal effect in the Medical Dictionary? Extrapyramidal effect explanation free. What is Extrapyramidal effect? Meaning of Extrapyramidal effect medical term. What does Extrapyramidal effect mean?
The primary objective of the study is to assess the safety and the anti-dyskinetic properties of sarizotan at various dosages for neuroleptic-induced TD.. The secondary objective of the study is to assess the effects of sarizotan on cognitive function in patients with neuroleptic-induced TD.. The diagnosis of neuroleptic-induced TD will be confirmed by history and physical examination. Patients will be evaluated at baseline, 2, 4, 8, and 12 weeks. Safety will be assessed by vital signs, ECG, routine blood tests, the ACTH stimulation test, and the clinicians and patients global impression of tolerability.. Procedures:. For efficacy, the primary outcome variable will be changes in the Abnormal Involuntary Movement Scale (AIMS), and a baseline score of ,3 (moderate) will be required for item 8 (Severity of Abnormal Movements). Quantitative evaluation of movements will be carried out in two ways. The first involves a series of instrumental and clinical measures that were developed as a battery ...
Umespirone (KC-9172) is a drug of the azapirone class which possesses anxiolytic and antipsychotic properties.[2][3][4][5] It behaves as a 5-HT1A receptor partial agonist (Ki = 15 nM), D2 receptor partial agonist (Ki = 23 nM), and α1-adrenoceptor receptor antagonist (Ki = 14 nM), and also has weak affinity for the sigma receptor (Ki = 558 nM).[2][6][7] Unlike many other anxiolytics and antipsychotics, umespirone produces minimal sedation, cognitive/memory impairment, catalepsy, and extrapyramidal symptoms.[1][5][6]. ...
bulbocapnine: was heading 1975-94 (Prov 1975-90); use APORPHINES to search BULBOCAPNINE 1975-94 (as Prov 1975-94); alkaloid from Corydalis cava and other plants; induces catalepsy probably due to its antagonism of DOPAMINE
Stress resistance can be lowered for some reason, it is not obvious to a person, and in this state, he is inclined to blame everything on himself.If the chorus of voices in his head be added and relatives to vote, the matter may even turn into a tragedy.Take care of your loved ones, be careful and lenient help a person regain confidence.. Disorders and Pathology apnea.Severe sleep disturbance, when a person during sleep may be interrupted breathing, he was afraid to fall asleep, waking up frequently during the night.Dream turns out defective, during the day there is a strong drowsiness.People with experience constant violation of lethargy during the day, can not concentrate, they complain of poor attention and memory.In this case, a person needs to pay attention to themselves and not to leave the sleep disorder without medical assistance.. There is such a disease as narcolepsy (catalepsy).People with this diagnosis acquire a disability as they can fall asleep suddenly, anywhere and in any ...
Haloperidol Teva is a medicine available in a number of countries worldwide. A list of US medications equivalent to Haloperidol Teva is available on the Drugs.com website.
Objective:A few case reports on the use of aripiprazole in neuroleptic-induced tardive dyskinesia have demonstrated positive effects. However its effectiveness in treatment of TD was still inconclusive. The aim of the present study was to investigate the efficacy of aripiprazole in management of pre-existing neuroleptic-induced tardive dyskinesia.. Method: Subjects with pre-existing neuroleptic-induced tardive dyskinesia were chosen from Taoyuan psychiatric center. Patients recruited would be treated with aripiprazole for cross-titration with previous antipsychotics in 8 weeks. We use AIMS, SAS, & BAS to assess the severity of TF and EPS. We record subjects age, sex, and other factors which have influence at the treatment response. Subjects are assessed every two weeks in the first month and then monthly until six months. ...
The abdominal finite element model was created to improve the abdominal part of the human body model ROBBY that should ensure the ability to predict the abdominal injury during various impact conditions. The abdominal model geometry was created on the basis of real anatomical human data. Tissue characteristics completing the organ geometry were obtained from public sources. The created abdominal model was consequently scaled and embedded into the ROBBY model representing a 50th percentile male. The updated ROBBY model was validated with a comparison of the simulation results during abdominal oblique impactor tests and abdominal frontal rigid bar tests with available cadaver experimental results. It was found that the updated ROBBY model with the new deformable abdominal model is able to predict the response of the human abdomen during various impact conditions very well ...
(a and b) Evaluations of stereotyped behaviors of experimental rats during an 8-week period. Data are expressed as the mean ± SEM. (n = 10 rats/group). The ini
Haloperidol is used in the treatment of schizophrenia.get complete information about haloperidol including usage, side effects, drug interaction, expert advice along with medicines associated with haloperidol at 1mg.com
Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.
Extrapyramidal side effects are symptoms that can occur if you're taking antipsychotic medications. Here's what they include and how they're treated.
CBD Oil For Dystonia - How CBD works with Dystonia and Dyskinesias? In studies with mice, the natural cannabinoid CBD attenuated catalepsy, characterized by muscular rigidity
Sleep paralysis or projective catalepsy is not an illness - even conventional scientists agree. As such, it is not something that necessitates cure. It is something, however, that can indeed be suppressed. Sometimes people evoke certain historic or mythical personalities to give them courage and the power of their own intent to stop their re-occurrence is not to be dismissed. Many people, due to religious or materialistic inculcation do end up suppressing their psi abilities, especially as children. I suppose this is better than suffering due to the misinformation they have been fed. However, the ideal is to learn that there is, in fact, nothing to fear. This frees one to see actually enjoy multidimensionality, to de-mystify the whole thing and to have their own, healthy, productive experiences. We speak from personal experience, hundreds of our colleagues have overcome these fears sparked by the religious status quo. It is not convenient for institutions that control minds for people to ...
OXON HILL, Md. - Forget the spelling. Victoria Allen was looking for a punch line.. "I only want a sentence if its funny," the 14-year-old from Green River, Wyoming, said upon getting the word "salaam" on Wednesday at the Scripps National Spelling Bee.. "Well," replied pronouncer Jacques Bailly, checking his computer screen. "I dont think I have one.". "Shame," said Victoria, looking a tad disappointed - even though she correctly spelled the word.. "The Big Bang Theory" doesnt have a monopoly on nerd TV humor, not the way the Bee is going. The preliminary rounds were just as memorable for comedic sentences as for any spellings or misspellings of words like "catalepsy" or "mastodon.". "Andre promised to regale his friends with tales of his entire odyssey," Bailly told one speller, "but it turned out just to be a 45-minute story about the time he got lost in Costco for 35 minutes.". After the laughter subsided, Lillian Allingham of Hockessin, Delaware, completed that bit of spelling "odyssey" ...
Zajdel, P.; Marciniec, K.; Maslankiewicz, A.; Grychowska, K.; Satala, G.; Duszynska, B.; Lenda, T.; Siwek, A.; Nowak, G.; Partyka, A.; Wrobel, D.; Jastrzebska-Wiesek, M.; Bojarski, A. J.; Wesolowska, A.; Pawlowski, M. Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT(1A)/5-HT(2A)/5-HT(7) and dopamine D(2)/D(3) receptors. Eur. J. Med. Chem. 2013, 60, 42-50 (http://www.ncbi.nlm.nih.gov/pubmed/23279866) ...
The dosage that haloperidol is administered at depends on several factors including patient age, body weight and the condition for which the drug is being prescribed. Some examples of the dosage schedule for haloperidol are described below.
extrapyramidal definition: associated with or involving neural paths situated outside or independent of the pyramidal tracts.; Of or pertaining to the neural pathways which are independent of the pyramidal…
JL13 [5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5] benzoxazepine fumarate] is a substance with a close structural resemblance to clozapine. However, it is less sensitive to oxidation and may therefore have less hematological side effects. In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia. The paw test represents a screening model for antipsychotic drugs that can discriminate between drugs with extrapyramidal side effects and drugs without. Haloperidol increased both forelimb retraction time and hindlimb retraction time (HRT), whereas both clozapine and JL13 increased only HRT. In the prepulse inhibition paradigm, all three drugs reversed the apomorphine- and the amphetamine-induced disruption of prepulse inhibition. However, whereas haloperidol was equally effective against both dopaminergic drugs, JL13 and clozapine were more effective against amphetamine. Finally, only JL13 was able to increase prepulse inhibition in ...
In previous times, masturbation received widespread condemnation. For example, in the 18th century, numerous treatises were written describing thephysical and mental consequences of masturbation (see Caird & Wincze,1977; Gagnon, 1977). It was during this time that a particularly well-knownSwiss physician, Tissot (1766), published a volume titled Onania, or a Trea-tise upon the Disorders Produced by Masturbation. Among the many physicaland mental disorders purportedly caused by masturbation were failing eye-sight, consumption, gonorrhea, hemorrhoids, digestive disorders, melancholy,catalepsy, imbecility, loss of sensation, lethargy, pervasive weakness of thenervous system, impotence, and insanity! Eventually, because of the scientificwork of Kinsey and others, more enlightened views about masturbationemerged. Today, in stark contrast, masturbation is prescribed as therapy (e.g.,see LoPiccolo & Lobitz, 1972; Zilbergeld, 1999). In fact, it turns out that di-rected masturbation (see Chapter 7) is a ...
Looking for Extrapyramidal System? Find out information about Extrapyramidal System. Descending tracts of nerve fibers arising in the cortex and subcortical motor areas of the brain. a group of brain structures in the hemispheres and... Explanation of Extrapyramidal System
Dystonic reactions are reversible extrapyramidal effects that can occur after administration of a neuroleptic drug. Symptoms may begin immediately or can be delayed hours to days. Although a wide vari... more
Higher affinity for D2 receptors (subsequently less blockade of 5-HT2), causing a greater effect on 'positive' symptoms' and a greater incidence of extrapyramidal side ...
Taking haloperidol can cause dangerous side effects or increase the risk of seizures in some people. This eMedTV resource discusses other precautions and warnings with haloperidol, including a list of people who should not take the drug at all.
8 Answers - Posted in: migraine, haloperidol - Answer: I cannot believe your doctor was going to give you Haldol for a migraine. ...
(1-Benzyl-pyrrolidin-3-ylmethyl)-methyl-amine/ACM91189058 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
I was in the ED of my local hospital just the other day and the ER doc gave IV Benedryl and Phenergan at first(which didnt work) the he suggested that I give the Haldol a try. Well folks im here to tell you that it was the worse mistake I
Recite: Cover the note-taking column with a sheet of paper. Then, looking at the questions or cue-words in the question and cue column only, say aloud, in your own words, the answers to the questions, facts, or ideas indicated by the cue-words ...
TY - JOUR. T1 - Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra. AU - Bolden-Watson, Carolyn. AU - Watson, Michael A.. AU - Murray, Karl D. AU - Isackson, Paul J.. AU - Richelson, Elliott. PY - 1993/9. Y1 - 1993/9. N2 - We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels in the substantia nigra/ventral tegmental area (SN/ VTA) 110% over control levels (significant difference from the control, p , 0.05). In contrast, the same analysis applied to the sections from clozapine-treated animals showed no significant change in NTR mRNA levels compared with matched control sections (p , 0.05). Thus, chronic treatment with haloperidol but not clozapine resulted in elevated levels of NTR mRNA ...
Synonyms for stereotyped behavior at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
Rationale Clozapine and the "atypical" antipsychotics are less prone than neuroleptics to induce extrapyramidal motor effects, worsening of the negative symptoms of schizophrenia and dysphoria. This is paralleled by preclinical evidence showing reduced suppression of behaviours aimed at the pursuit of reward, with increased measures of reward efficacy. Serotonin 5-HT2 receptors seem to play a role in determining this profile ...
Disclaimer. Pallipedia does not endorse or recommend any commercial products, processes, or services; therefore, their mention cannot be construed as such. Pallipedia should not be used as guidance to treatment and its purpose is to provide users with information to help them better understand conditions and the current range of approaches related to palliative care. Pallipedia urges health care providers and patients to always consult other relevant and up-to-date experts.. Functional design and content: Roberto ...
The use of atypical antipsychotic drugs in kids (up to 18 years old) tipples the chances of getting type 2 diabetes later in life.
Haloperidol is a long-acting injection that is used to treat schizophrenia and other mental health problems. Haloperidol side effects and uses at Patient.
N-Arachidonoyl dopamine (NADA) is an endocannabinoid that acts as an agonist of the CB1 receptor and the transient receptor potential V1 (TRPV1) ion channel. NADA was first described as a putative endocannabinoid (agonist for the CB1 receptor) in 2000 and was subsequently identified as an endovanilloid (agonist for TRPV1) in 2002. NADA is an endogenous arachidonic acid based lipid found in the brain of rats, with especially high concentrations in the hippocampus, cerebellum, and striatum. It activates the TRPV1 channel with an EC50 of approximately of 50nM which makes it the putative endogenous TRPV1 agonist. In mice, NADA was shown to induce the tetrad of physiological paradigms associated with cannabinoids: hypothermia, hypo-locomotion, catalepsy, and analgesia. NADA has been found to play a regulatory role in both the peripheral and central nervous systems, and displays antioxidant and neuroprotectant properties. NADA has also been implicated in smooth muscle contraction and vasorelaxation in ...
Clotiapine (Entumine) is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970. Some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related.Despite its profile of a relatively high incidence of extrapyramidal side effects it has demonstrated efficacy in treatment-resistant schizophrenic patients according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too. ...
Metabotropic glutamate receptors (mGluRs) couple the actions of glutamate to intracellular second messenger systems through G-proteins. The mGluRs play an important role in the regulation of basal ganglia function. Ligand binding studies have revealed that the basal ganglia contain at least two pharmacological types of metabotropic binding sites. Agonists of mGluRs can affect both in vitro electrophysiologic responses of striatal neurons and motor behavior in vivo. Recently, cDNAs encoding five mGluRs have been cloned, each with distinct structural and pharmacological properties. In order to elucidate the function of these receptors in the biology of the extrapyramidal motor system, we have used in situ hybridization to examine the regional and cellular expression patterns of mGluR1-mGluR5 in the adult rat basal ganglia. In the striatum, all of these mGluRs were present in widely varying relative densities and cellular patterns. MGluR5 was particularly prominent, and exhibited a heterogeneous ...
Get information, facts, and pictures about Haloperidol at Encyclopedia.com. Make research projects and school reports about Haloperidol easy with credible articles from our FREE, online encyclopedia and dictionary.
The extrapyramidal system is the part of the motor system involved in modulation and regulation of movement. As its name suggests, it is distinct from the motor fibres that are relayed through the pyramids of the medulla oblongata (corticospinal ...
Buy Clozapine (CAS 5786-21-0), an atypical antipsychotic. Join researchers using high quality Clozapine from Abcam and achieve your mission, faster.
Expression of PPP1R8 (ard-1, ARD1, NIPP-1, NIPP1, PRO2047) in vagina tissue. Antibody staining with HPA027406, HPA027417 and HPA027452 in immunohistochemistry.
The review by Kennedy et al provides useful information on the effectiveness of risperidone compared with conventional neuroleptics (mainly haloperidol) in patients with chronic schizophrenia. The reviewers increased the robustness of their conclusions by including only randomised controlled trials. One of the main contributions of the review is to highlight the clear limitations of the primary studies. Most of the trials studied patients for ,12 weeks and all but 1 trial randomised only patients with chronic schizophrenia and used a cut off of 20% in rating scales (BPRS and PANSS) to measure improvement. No suitable information regarding clinically meaningful outcomes such as relapse, hospitalisation, quality of life, social functioning, or employment status of the patients was provided by the original trials. The absence of cost data precluded an analysis of the cost effectiveness of risperidone. Additionally, although risperidone seems to cause fewer EPS, this medication was compared with a ...
Is Extrapyramidal Disorder a common side effect of Abilify? View Extrapyramidal Disorder Abilify side effect risks. Female, 48 years of age, was diagnosed with bipolar ii disorder, depression and took Abilify . Patient was hospitalized.
The dose of HALDOL Decanoate 50 or HALDOL Decanoate 100 should be expressed in terms of its haloperidol content. The starting dose of haloperidol decanoate should be based on the patients age, clinical history, physical condition, and response to
Alopecia - hypogonadism - extrapyramidal disorder information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
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May cause CNS depression; may impair ability to operate heavy machinery or driving. Safety of prolonged administration of 100 mg/day PO not established. Leukopenia/neutropenia and agranulocytosis reported; possible risk factors. Tags: action, mechanism, haloperidol. ...
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Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis | The BMJAtypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis | The BMJ

... was originally used to describe drugs that in animal models predict antipsychotic effects but do not produce catalepsy - most ...
more infohttps://www.bmj.com/content/321/7273/1371

Effects of chronic treatment with uridine on striatal dopamine release and dopamine related behaviours in absence or presence...Effects of chronic treatment with uridine on striatal dopamine release and dopamine related behaviours in absence or presence...

The animals chronically treated with uridine showed significant increases in the stereotypy scores and in the catalepsy induced ... The animals chronically treated with uridine showed significant increases in the stereotypy scores and in the catalepsy induced ... Behavioural tests such as haloperidol-induced catalepsy or apomorphine-induced stereotypics were also performed 4-7 days after ... Behavioural tests such as haloperidol-induced catalepsy or apomorphine-induced stereotypics were also performed 4-7 days after ...
more infohttps://iris.univr.it/handle/11562/14705

catalepsy - definition and meaningcatalepsy - definition and meaning

catalepsy: A condition characterized by lack of response to external stimuli and by muscular rigidity, so that the limbs remain ... If it is catalepsy he is suffering from, then it is a kind of catalepsy I never heard of. ... From cata- + -lepsy; ultimately from Ancient Greek κατάληψις (katalēpsis, "act of seizing"), from καταλαμβάνω (katalambanō, "I ... If a solar spectrum is suddenly brought into a dark room it may produce catalepsy, which is also produced by looking at the sun ...
more infohttps://www.wordnik.com/words/catalepsy

Catalepsy (band) - WikipediaCatalepsy (band) - Wikipedia

Catalepsy is an American deathcore band formed in 2004. They have released one EP, Godless, and two studio albums, Iniquity and ... Catalepsy was founded in 2004 as a thrash/metalcore three-piece. From August 2006 the bands sound moved towards deathcore. ... He was replaced by Rick Norman, formerly of In The Ruins, also a past member of Catalepsy. On December 3, 2010, the band ... Catalepsy disbanded in 2013 but re-formed in September 2014. Current lineup Andrew Carothers - vocals (2007-2008, 2010, 2014- ...
more infohttps://en.wikipedia.org/wiki/Catalepsy_(band)

Catalepsies | definition of catalepsies by Medical dictionaryCatalepsies | definition of catalepsies by Medical dictionary

... catalepsies explanation free. What is catalepsies? Meaning of catalepsies medical term. What does catalepsies mean? ... Looking for online definition of catalepsies in the Medical Dictionary? ... catalepsy. (redirected from catalepsies). Also found in: Dictionary, Thesaurus, Encyclopedia. catalepsy. [kat´ah-lep″se] a ... catalepsy. (kăt′l-ĕp′sē). n. pl. catalep·sies A condition characterized by lack of response to external stimuli and by muscular ...
more infohttp://medical-dictionary.thefreedictionary.com/catalepsies

Pharmacological evaluation of catalepsy in low calcium and/or magnesium deficient feeding micePharmacological evaluation of catalepsy in low calcium and/or magnesium deficient feeding mice

Mice developped catalepsy after 3 weeks on the LCa/Mg diet. LCa/Mg diet-induced catalepsy was improved by the administration of ... The present study aimed to test the hypothesis that catalepsy, a behavioral immobility and one of the Parkinsonian symptoms, ... These results suggest that catalepsy in LCa/Mg mice might result from a hypofunction of dopaminergic neurons. Moreover, our ... DA receptor D2 agonist bromocriptine and the DA releaser amantadine were tested for their effects on the induced catalepsy. ...
more infohttp://www.scirp.org/journal/PaperDownLaodReport.aspx?PaperID=24973

Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy. | Journal of Pharmacology...Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy. | Journal of Pharmacology...

Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy.. B Hitzemann, K Dains, S ... Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy.. B Hitzemann, K Dains, S ... Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy.. B Hitzemann, K Dains, S ... Previous data have suggested that the genetic variability in the sensitivity to haloperidol-induced catalepsy is associated ...
more infohttp://jpet.aspetjournals.org/content/271/2/969?ijkey=01a01c7426e235ec20fa9298d2f158251a122450&keytype2=tf_ipsecsha

AID 129986 - Compound was evaluated for inhibitory activity on haloperidol induced catalepsy (anti-cataleptic activity) in mice...AID 129986 - Compound was evaluated for inhibitory activity on haloperidol induced catalepsy (anti-cataleptic activity) in mice...

Compound was evaluated for inhibitory activity on haloperidol induced catalepsy (anti-cataleptic activity) in mice after ...
more infohttps://pubchem.ncbi.nlm.nih.gov/bioassay/129986

On catalepsy and catatonia and the predictability of the catalepsy test for neuroleptic activity - Semantic ScholarOn catalepsy and catatonia and the predictability of the catalepsy test for neuroleptic activity - Semantic Scholar

Morphine catatonia was more susceptible to inhibition by the amygdaloid lesions than the catalepsy/catatonia induced by the ... Therefore, in a attempt to differentiate the behavioural states termed catalepsy and catatonia, haloperidol and morphine were ... peromide and spiroxatrine catalepsy/catatonia. In contrast, morphine catatonia was only partially reduced by ablating the ... On catalepsy and catatonia and the predictability of the catalepsy test for neuroleptic activity. @article{Costall1974OnCA, ...
more infohttps://www.semanticscholar.org/paper/On-catalepsy-and-catatonia-and-the-predictability-Costall-Naylor/2488f0507fa266d5f2c72284ff44c57854fbc04d

catalepsy | Traducción de inglés a Español - Oxford Dicitionariescatalepsy | Traducción de inglés a Español - Oxford Dicitionaries

Traducción de catalepsy , The term atypical was originally used to describe drugs that in animal models predict antipsychotic ... A spokesperson for the cemetery told the newspaper: We want to be pioneers and avoid catalepsy cases, in which a person gets ... Stupor or catalepsy, mutism, posturing/grimacing/stereotypy, echolalia or echopraxia and excessive motor activity were the main ... Furthermore, high dose morphine is well reported as a cause of rigidity, catalepsy, akathisia, and myoclonus, which must add to ...
more infohttps://es.oxforddictionaries.com/traducir/ingles-espanol/catalepsy

Change in hypothermia and catalepsy induced by cannabinoids or morphine in mice tolerant to these substances<...Change in hypothermia and catalepsy induced by cannabinoids or morphine in mice tolerant to these substances<...

Narimatsu S, Yamamoto I, Watanabe K, Yoshimura H. Change in hypothermia and catalepsy induced by cannabinoids or morphine in ... Change in hypothermia and catalepsy induced by cannabinoids or morphine in mice tolerant to these substances. In: European ... Change in hypothermia and catalepsy induced by cannabinoids or morphine in mice tolerant to these substances. / Narimatsu, ... Narimatsu, S, Yamamoto, I, Watanabe, K & Yoshimura, H 1987, Change in hypothermia and catalepsy induced by cannabinoids or ...
more infohttps://okayama.pure.elsevier.com/en/publications/change-in-hypothermia-and-catalepsy-induced-by-cannabinoids-or-mo

Involvement of female sex hormones in the cannabinoid-induced catalepsy and analgesia in ovarectomized mice | Annals of General...Involvement of female sex hormones in the cannabinoid-induced catalepsy and analgesia in ovarectomized mice | Annals of General...

Both the catalepsy and analgesia induced by different doses of synthetic cannabinoid WIN 55,212-2 (2 and 4 mg/kg, i.p.) were ... WIN 55,212-2 caused (P,0.001) catalepsy and analgesia in three groups in a dose-dependent manner which was inhibited by AM251 ( ... However, progesterone exerted a strong enhancing effect (P,0.05) on catalepsy or analgesia induced by low dose WIN 55,212-2 in ... Field E.F., Whishaw I.Q., Pellis S.M.: Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in ...
more infohttps://annals-general-psychiatry.biomedcentral.com/articles/10.1186/1744-859X-7-S1-S263

Effects of Estrogen and Progesterone on Catalepsy and
Motor and Balance Impairment Classified as
Haloperidol-induced...Effects of Estrogen and Progesterone on Catalepsy and Motor and Balance Impairment Classified as Haloperidol-induced...

The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment ... Aims Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of ... The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment ... Aims Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of ...
more infohttp://jogcr.com/browse.php?a_id=26&slc_lang=fa

Rotarod test and Catalepsy bar test: behavioral testing and neuromodulation of Aloe vera in MPTP induced Parkinsons disease...Rotarod test and Catalepsy bar test: behavioral testing and neuromodulation of Aloe vera in MPTP induced Parkinson's disease...

Rotarod test and Catalepsy bar test: behavioral testing and neuromodulation of Aloe vera in MPTP induced Parkinsons disease ...
more infohttps://www.ijbcp.com/index.php/ijbcp/article/view/2283/1834

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors | PNASDistinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors | PNAS

... which can include catalepsy and drug-induced parkinsonism (5). Haloperidol-induced catalepsy is thought to result from high ... Haloperidol-Induced Catalepsy.. Mice were injected with haloperidol (1.5 mg/kg i.p.) and returned to their home cage for 60 min ... Haloperidol-Induced Catalepsy Is Strongly Reduced in D32f/fD2RCre+ Mice.. First-generation antipsychotic drugs such as ... A and B) Mice were injected with 1.5 mg/kg haloperidol, and 60 min later catalepsy was assessed by measuring the latency until ...
more infohttps://www.pnas.org/content/107/33/14845?ijkey=99186383769486ddcd5cfd7bf4ebfc99bbb0df7b&keytype2=tf_ipsecsha

Stories by Percy Collins - Scientific AmericanStories by Percy Collins - Scientific American

Catalepsy in Insects. Experiments Showing how Insects Pass Periodically into a Trance ...
more infohttps://www.scientificamerican.com/author/percy-collins/

Frontiers | Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats | PharmacologyFrontiers | Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats | Pharmacology

CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion ... CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion ... Locomotor activity, vacuous chewing movements and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated ... Locomotor activity, vacuous chewing movements and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated ...
more infohttps://www.frontiersin.org/articles/10.3389/fphar.2016.00343/full

Plus itPlus it

Catalepsy.. Catalepsy was observed only at high doses of brexpiprazole and aripiprazole, with ED50 values of 20 and 42 mg/kg p. ... Catalepsy in Rats. Rats were fasted for 15 hours before administration of test compounds. Catalepsy was measured at 1, 2, 4, 6 ... Rats were forced to hang by their right forepaw on the upper edge of a steel can (diameter: 6 cm × height 10 cm). A catalepsy ... Brexpiprazole induced catalepsy (ED50 = 20) well above clinically relevant D2 receptor occupancies, suggesting a low risk for ...
more infohttp://jpet.aspetjournals.org/content/350/3/605

November 27, 1880 - Scientific AmericanNovember 27, 1880 - Scientific American

Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
more infohttps://www.scientificamerican.com/magazine/supplements/1880/11-27/

Diseases - Runnels County TXGenWebDiseases - Runnels County TXGenWeb

Catalepsy - Condition which causes Seizures/trances or unconsciousness. Catarrh - Inflammation of a mucous membrane, especially ... Ecstasy - A form of catalepsy characterixed by loss of reason. Edema - Nephrosis; swelling of tissues. see Dropsy. Edema of ...
more infohttps://sites.google.com/site/runnelscountytxgenweb/general-research-links/diseases

Oscar Trejo Jr, Author at Ground ReportOscar Trejo Jr, Author at Ground Report

A Look at Catalepsy. Oct 19, 2008. , Health & Science, Lifestyle. Catalepsy is a condition in which a person loses their desire ... A patient with catalepsy is said to be in a catatonic state. He […] ...
more infohttps://www.groundreport.com/author/flames22/

Systematic protein-protein interaction mapping for clinically relevant human GPCRs | Molecular Systems BiologySystematic protein-protein interaction mapping for clinically relevant human GPCRs | Molecular Systems Biology

Catalepsy score.. Catalepsy behavior was induced by the D2R antagonist haloperidol (1.5 mg/kg, i.p.), as previously described ( ... Interestingly, our results showed that in the GPR37−/− mice the catalepsy scores were significantly lower (P , 0.01) than in ... Catalepsy testing was performed under dim (16 lux) light conditions. The sample size was initially set as five determinations ... The influence of systemic injection of ADORA2A antagonist SCH 58261 (1 mg/kg, i.p.) on the catalepsy induced by haloperidol ( ...
more infohttp://msb.embopress.org/content/13/3/918

Anesthetics Flashcards by J Irc | BrainscapeAnesthetics Flashcards by J Irc | Brainscape

dissoc anesthesia; catalepsy; incr secretions. analgesic. postop dysphoria (hallucinations for days after: one reason not to ...
more infohttps://www.brainscape.com/flashcards/anesthetics-3292409/packs/5061469

pace facts, information, pictures | Encyclopedia.com articles about pacepace facts, information, pictures | Encyclopedia.com articles about pace

... catalepsy •Basie, Casey, Gracie, lacy, OCasey, pace, pacy, precis, racy, spacey, Stacey, Sulawesi, Tracy •cadency • ...
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Acute Catatonia on Medical Wards: A Case SeriesAcute Catatonia on Medical Wards: A Case Series

... and catalepsy. Her mobility had deteriorated, with selective speech, mute episodes, and poor oral intake noted by medical staff ...
more infohttps://www.medscape.com/viewarticle/900165_3
  • The animals chronically treated with uridine showed significant increases in the stereotypy scores and in the catalepsy induced by an acute haloperidol challenge with respect to saline treated rats. (univr.it)
  • In the present study, we evaluated whether the ovarian sex hormones are involved in the cannabinoid-induced catalepsy and analgesia in ovarectomized (OVX) female mice. (biomedcentral.com)
  • Both the catalepsy and analgesia induced by different doses of synthetic cannabinoid WIN 55,212-2 (2 and 4 mg/kg, i.p.) were examined in three groups in the presence or absence of the CB1 antagonist AM251. (biomedcentral.com)
  • Pretreatment with estradiol caused no effect on cannabinoid-induced catalepsy or analgesia in OVX group. (biomedcentral.com)
  • The present data demonstrated for the first time that ovarian female hormone progesterone is involved in both cannabinoid-induced catalepsy and analgesia in female mice. (biomedcentral.com)
  • Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most which are mediated by CB1 receptors. (biomedcentral.com)
  • On examination she presented with waxy flexibility, negativism, new onset increased tone of her left arm, posturing, and catalepsy. (medscape.com)
  • Findings One to 7-day treatment with estrogen had a protective effect on haloperidol-induced extrapyramidal disorders such that it significantly improved catalepsy and motor impairment in the rats and restored and normalized their motor levels. (jogcr.com)
  • Brexpiprazole induced catalepsy (ED 50 = 20) well above clinically relevant D 2 receptor occupancies, suggesting a low risk for extrapyramidal side effects. (aspetjournals.org)
  • The hysterics' observable disorders, such as catalepsy, as well as their visual experiences, including hallucination and delirium, were deemed manifest content and, as such, not to be taken at face value. (oxforddictionaries.com)
  • The magicians of Egypt in modern times have been long celebrated adepts in charming serpents, and particularly by pressing the nape of the neck, they throw them into a kind of catalepsy , which renders them stiff and immovable -- thus seeming to change them into a rod. (wordnik.com)
  • Admittedly, he suffers from a strange illness which doctors merely call catalepsy, when the muscles become stiff and rigid. (oxforddictionaries.com)
  • A person who has exhibited symptoms as severe as catalepsy is very ill and will need continued and long-term care to facilitate recovery from serious emotional problems. (thefreedictionary.com)
  • For several years I had been subject to attacks of the singular disorder which physicians have agreed to term catalepsy , in default of a more definitive title. (wordnik.com)
  • The co-administration of flutamide significantly reduced the protective effect of estrogen on catalepsy and motor balance impairment induced by haloperidol. (jogcr.com)
  • It acts in a peculiar manner upon the nervous centers, occasioning that strange condition of the nervous system called catalepsy , in which the limbs of the unconscious patient remain stationary in whatever position they may be placed. (wordnik.com)
  • It can only have been the condition that is called catalepsy ," said Challenger. (wordnik.com)
  • Catalepsy is a condition in which a person loses their desire to move. (groundreport.com)
  • If a solar spectrum is suddenly brought into a dark room it may produce catalepsy , which is also produced by looking at the sun, or a lime light, or an electric light. (wordnik.com)
  • A spokesperson for the cemetery told the newspaper: 'We want to be pioneers and avoid catalepsy cases, in which a person gets completely paralysed for a few hours and ends up buried as if they were dead. (oxforddictionaries.com)