Catalase: An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Acatalasia: A rare autosomal recessive disorder resulting from the absence of CATALASE activity. Though usually asymptomatic, a syndrome of oral ulcerations and gangrene may be present.Blotting, Southwestern: A method that is used to detect DNA-protein interactions. Proteins are separated by electrophoresis and blotted onto a nitrocellulose membrane similar to Western blotting (BLOTTING, WESTERN) but the proteins are identified when they bind labeled DNA PROBES (as with Southern blotting (BLOTTING, SOUTHERN)) instead of antibodies.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Staphylococcus lugdunensis: A species of gram-positive bacteria in the family STAPHYLOCOCCACEAE. It is responsible for skin and soft-tissue infections among others, and is part of the normal human skin flora.Gene Expression Regulation, Enzymologic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Superoxide Dismutase: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Gene Expression Regulation, Fungal: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Genes, Fungal: The functional hereditary units of FUNGI.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Genes, Bacterial: The functional hereditary units of BACTERIA.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Glutathione Peroxidase: An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.PeroxidasesReactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.LIM Domain Proteins: A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Recombinant Proteins: Proteins prepared by recombinant DNA technology.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Foot Dermatoses: Skin diseases of the foot, general or unspecified.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Chloramphenicol O-Acetyltransferase: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Cat Diseases: Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
"Entrez Gene: ACOX1 acyl-Coenzyme A oxidase 1, palmitoyl". Human ACOX1 genome location and ACOX1 gene details page in the UCSC ... 2001). "Catalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorder". J. Biol. Chem. 275 (47 ... Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene. The protein encoded by this ... Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very ...
Its 16S rRNA gene sequences were no more than 90% similar to any other Gammaproteobacteria 16S rRNA gene sequence, and thus ... Oxidase and catalase enzymes were present. Its principle fatty acids are monounsaturated, with principle fatty acids being C18: ... 16S ribosomal RNA gene clones identified as belonging to the genus Oleispira were found to be very commonly occurring in ... Based on sequencing of 16S ribosomal RNA genes conducted by Yakimov et al., phylogenetically, this organism is related most ...
It is catalase positive, oxidase positive, and exhibits strictly aerobic metabolism. Optimum growth temperature is 25-37 C. It ... This encodes 2639 protein coding genes. Parte, A.C. "Kytococcus". www.bacterio.net. "Kytococcus sedentarius". www.vumicro.com. ...
CAT, catalase. External IDs. HomoloGene: 55514 GeneCards: CAT Gene ontology. Molecular function. • homodimerisasi protein. • ... "Catalase". MadSci FAQ. madsci.org. Diakses tanggal 2009-03-05.. *. "Catalase and oxidase test video". Regnvm Prokaryotae. ... "Catalase Procedure". MicrobeID.com. Diakses tanggal 2009-04-22.. *. "Catalase Molecule of the Month". Protein Data Bank. ... catalase activity. • antioxidant activity. • heme binding. • NADP binding. • enzyme binding. • oxidoreductase activity. • ...
Welinder KG (1991). "Bacterial catalase-peroxidases are gene duplicated members of the plant peroxidase superfamily". Biochim. ... and bacterial catalase- peroxidases, exhibiting both peroxidase and catalase activities. It is thought that catalase-peroxidase ...
The semi-quantitative catalase activity of all isolates is reactive (>45 mm). Differential characteristics The nearest ... phylogenetic neighbours, according to 16S rRNA gene sequence similarity, are M. neworleansense and all M. porcinum isolates ...
Of the 1422 genes predicted, 1364 were protein-coding genes, and were 58 RNAs. The majority of the genome (78.5%) is made up of ... C. curutm also had negative results for indole, catalase, and urease tests. According to Mavrommatis and colleagues, the genome ... A 16S rRNA gene sequence analysis revealed that the two isolates represent a distinct lineage within the family ...
Its size is 4 million base pairs, with 3,959 genes; 40% of these genes have had their function characterised, with possible ... It is distinguished from other mycobacteria by its production of catalase and niacin. Other tests to confirm its identity ... Results reveal new relationships and drug resistance genes not previously associated and suggest some genes and intergenic ... M. tuberculosis can also grow on the lipid cholesterol as a sole source of carbon, and genes involved in the cholesterol use ...
... has been shown to interact with three proteins: Abl gene, catalase, and SORBS2. The protein Abl gene is also known as ... "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)". Nagy, Ádám; Pongor, ... Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene. ... The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer. The ABL2 gene product is expressed as two ...
Produces a low level of heatstable catalase and is negative for reduction of nitrates. Differential characteristics The 16S ... rRNA and hsp65 gene sequences of M. canariasense are unique. Most closely related to Mycobacterium diernhoferi and ...
Halaban R, Moellmann G (1990). "Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity ... Mutations in the mouse Tyrp1 gene are associated with brown pelage and in the human TYRP1 gene with oculocutaneous albinism ... Abbott C, Jackson IJ, Carritt B, Povey S (1991). "The human homolog of the mouse brown gene maps to the short arm of chromosome ... Tyrosinase-related protein 1, also known as TYRP1, is an enzyme which in humans is encoded by the TYRP1 gene. Tyrp1 is a ...
Examples include the transforming growth factor Beta receptor gene and the BAX gene. Each target leads to different phenotypes ... Additionally, catalase reduces mutations, whereas copper and nickel increase mutations by increasing reduction of peroxides. ... Duldulao, M. P.; Lee, W.; Le, M.; Chen, Z.; Li, W.; Wang, J.; Gao, H.; Li, H.; Kim, J.; Garcia-Aguilar, J. (2012). "Gene ... MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors ...
Oxygen-Dependent Regulation of the Expression of the Catalase Gene katA of Lactobacillus sakei LTH677. Christian Hertel, Gudrun ... In strain LTH681, the stress operon dnaK has been characterized in 1999 as a heat shock protein gene. There is only one gene ( ... It is composed of 1884661 nucleotides forming 1879 protein genes and 84 RNA genes. Bredholt, S.; Nesbakken, T.; Holck, A. (2001 ... there is an oxygen-dependent regulation of the expression of the catalase gene katA. ...
... inactivates catalase by reducing its gene's transcription as well as directly targeting the enzyme itself. ... MvfR is a gene which produces a transcription factor which activates phnAB genes. These genes produce the molecule quinolone ... Mutations in genes affecting V-ATPase synthesis and assembly, vesicle transport machinery, protein sorting machinery all confer ... When the lung is confronted with pyocyanin, an increased concentration of catalase and superoxide dismutase is seen in order to ...
It is urease and catalase positive. An obligate aerobe, M. luteus is found in soil, dust, water and air, and as part of the ... a contaminant in sick patients and is resistant by slowing of major metabolic processes and induction of unique genes. It is a ...
This is based, in part, on evidence in human and mouse that inherited deficiencies in DNA repair genes often cause accelerated ... The maximum life span of transgenic mice has been extended about 20% by overexpression of human catalase targeted to ... Friedman DB, Johnson TE (1 January 1988). "A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces ... Koubova J, Guarente L (2003). "How does calorie restriction work?". Genes & Development. 17 (3): 313-321. doi:10.1101/gad. ...
In 1997 it was described how ARF's bind to auxin-response gene elements in promoters of auxin regulated genes, generally ... IAA inhibits the photorespiratory-dependent cell death in photorespiratory catalase mutants. This suggests a role for auxin ... activating transcription of that gene when an Aux/IAA protein is not bound. ...
... the gene required for quorum sensing (QS) signal molecule AI-2 synthesis and E. corrodens can produce AI-2 signal for cell-to- ... catalase-negative, urease-negative, and indole-negative, and reduce nitrate to nitrite.[citation needed] In 2006, Azakami et al ...
2007). "Circadian control by the reduction/oxidation pathway: Catalase represses light-dependent clock gene expression in the ... There are specific genes that determine the regulation of circadian rhythm in conjunction with light. When light activates NMDA ... Genes also involved with entrainment are PER1 and PER2. Some important structures directly impacted by the light-sleep ... Yan, Lily (2009-09-24). "Expression of clock genes in the suprachiasmatic nucleus: Effect of environmental lighting conditions ...
Mutations in the katG gene make the enzyme catalase peroxidase unable to convert INH to its biologically active form. Hence, ... A gene probe for rpoB is available in some countries. This serves as a useful marker for MDR-TB, because isolated RMP ... Mutations in these genes allow the bacteria to have a higher overall mutation rate and to accumulate mutations that cause drug ... One example is a mutation in the rpoB gene, which encodes the beta subunit of the bacteria's RNA polymerase. In non-resistant ...
Occurrence of acatalasia is often the result of mutation in the CAT gene which codes for the enzyme catalase. Researchers ... He had spread hydrogen peroxide on the diseased part, but oxygen was not generated due to the lack of catalase. List of ... Takahara, S.; Miyamoto, H. Three cases of progressive oral gangrene due to lack of catalase in the blood. Nippon Jibi-Inkoka ... is an autosomal recessive peroxisomal disorder caused by low levels of the enzyme catalase. The disorder is relatively benign, ...
Nuclear gene expression depends on chloroplast-to-nucleus signalling and responds to photosynthetic signals, such as the ... Catalase Oxidative stress Peroxidase Peroxiredoxin classification index Reactive oxygen species Superoxide dismutase Rhee S, ...
... the genes for nitrogen fixation are in a large, contiguous cluster (under the control of multiple promoters), including genes ... In addition, the organisms produce peroxidases and catalases which help scavenge any oxygen left in the cell. The circadian ... Cyanothece has the genes for the use of a variety of sugar molecules; although glycerol is the only one that has been used ... Many of the genes that are unique to the genera have homologs in anaerobic bacteria, including those responsible for formate ...
Streptococci are catalase-negative. S. pyogenes can be cultured on blood agar plates. Under ideal conditions, it has an ... The name is derived from Greek words meaning chain(Strepto) of berries (coccus) and pus(pyo)-forming(genes), because ... Zimmer, Carl (2016-06-03). "Scientists Find Form of Crispr Gene Editing With New Capabilities". The New York Times. ISSN 0362- ... origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene ...
Deregulation of FOXO3a is involved in tumorigenesis, for example translocation of this gene with the MLL gene is associated ... It is thought that FOXO3a is also involved in protection from oxidative stress by upregulating antioxidants such as catalase ... "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily". Genomics. 47 (2): 187-99 ... "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily". Genomics. 47 (2): 187-99 ...
Genes[edit]. PEX genes encode the protein machinery ("peroxins") required for proper peroxisome assembly, as described above. ... catalase converts it to H2O through this reaction: 2. H. 2. O. 2. →. 2. H. 2. O. +. O. 2. {\displaystyle 2\mathrm {H} _{2}\ ... Genes that encode peroxin proteins include: PEX1, PEX2 (PXMP3), PEX3, PEX5, PEX6, PEX7, PEX10, PEX11A, PEX11B, PEX11G, PEX12, ... doi:10.1016/j.gene.2009.09.014. PMID 19818387.. *^ Gabaldón T, Capella-Gutiérrez S (Oct 2010). "Lack of phylogenetic support ...
Gene mutations Numerous assays for in vitro gene-mutations were performed and were predominantly negative. One study with E. ... The catalase activity of liver and kidney of the treated animals was inhibited by 50%, but the red cell catalase was unaltered ... 1981 mitotic gene S. cerevisiae 12.5 mg/ml ? negative Zimmermann conversion(*) D7 & Scheel, 1981 mitotic gene S. cerevisiae 300 ... Liver catalase activity was reduced at 250 and 1250 ppm in a dose-dependent manner (Bagdon et al., 1956; Annex I, reference 23 ...
The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.. Zhang Y1, Heym B, Allen B, Young D, Cole ... A single M. tuberculosis gene, katG, encoding both catalase and peroxidase, restored sensitivity to INH in a resistant mutant ... clinical isolates that are resistant to INH show reduced catalase activity and a relative lack of virulence in guinea-pigs. ...
IPR040333 Catalase_3. IPR024708 Catalase_AS. IPR024711 Catalase_clade1/3. IPR011614 Catalase_core. IPR037060 Catalase_core_sf. ... IPR040333 Catalase_3. IPR024708 Catalase_AS. IPR024711 Catalase_clade1/3. IPR011614 Catalase_core. IPR037060 Catalase_core_sf. ... IPR002226 Catalase_haem_BS. IPR010582 Catalase_immune_responsive. IPR020835 Catalase_sf. PANTHERi. PTHR11465 PTHR11465, 1 hit ... PS00437 CATALASE_1, 1 hit. PS00438 CATALASE_2, 1 hit. PS51402 CATALASE_3, 1 hit. ...
Exonuclease III and the catalase hydroperoxidase II in Escherichia coli are both regulated by the katF gene product. B D Sak, A ... Exonuclease III and the catalase hydroperoxidase II in Escherichia coli are both regulated by the katF gene product ... Exonuclease III and the catalase hydroperoxidase II in Escherichia coli are both regulated by the katF gene product ... Exonuclease III and the catalase hydroperoxidase II in Escherichia coli are both regulated by the katF gene product ...
... we functionally analysed these three catalase-peroxidase genes and found that MgCatD-1, encoding a secreted catalase-peroxidase ... Functional analysis of catalase-peroxidase encoding genes in the fungal wheat pathogen Zymoseptoria tritici. ... Similar to many plant pathogens, Z. tritici possesses three catalase-peroxidase genes that are known to detoxify H2O2 ... These results show that secreted catalase-peroxidase is an important pathogenicity factor for successful pathogenesis of Z. ...
In this study, we have cloned katB, encoding one catalase gene of P. aeruginosa. The gene was cloned on a 5.4-kb EcoRI fragment ... Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: ... Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: ... Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: ...
Buy Catalase gene silencers from Santa Cruz. RNAi products available in siRNA, shRNA Plasmid and shRNA Lentiviral Particle ... Catalase gene silencers are available as Catalase siRNA, Catalase shRNA Plasmid, Catalase shRNA Lentiviral Particles. Gene ... Catalase siRNA, shRNA Plasmid and Lentiviral Particle Gene Silencers. Catalase siRNA, shRNA Plasmid and Lentiviral Particle ... Catalase Antibodies for analysis of cellular responses to Catalase si/shRNA Gene Silencers ...
Here we present the molecular characterization of its corresponding gene, demonstra … ... is a model system for studying gene regulation and development. The CAN5 cDNA is one of several clones isolated based on ... catA, a New Aspergillus Nidulans Gene Encoding a Developmentally Regulated Catalase Curr Genet. 1996 Mar;29(4):352-9. ... However, catA expression is not dependent on the developmental regulatory genes brlA, abaA and wetA. Direct catalase activity ...
The catalase (CAT) enzyme is involved in the repair of ROS. Therefore, we investigate the association between CAT gene ... Association Between Catalase Gene Polymorphisms and Risk of Chronic Hepatitis B, Hepatitis B Virus-Related Liver Cirrhosis and ... The polymerase chain reaction-restriction fragment length polymorphism strategy was used to detect CAT gene rs1001179, rs769217 ...
The structural gene for the catalase of Neisseria gonorrhoeae was cloned into a Kat- strain of that organism by using a ... Cloning and characterization of the catalase gene of Neisseria gonorrhoeae: use of the gonococcus as a host organism for ... Cloning and characterization of the catalase gene of Neisseria gonorrhoeae: use of the gonococcus as a host organism for ... Cloning and characterization of the catalase gene of Neisseria gonorrhoeae: use of the gonococcus as a host organism for ...
Roles of an Inactive Domain in Catalase-Peroxidase Catalysis: Modulation of Active Site Architecture and Function by Gene ... Catalase-peroxidases are unique heme proteins because they catalyze peroxide decomposition by two separate mechanisms, catalase ... In order to determine its role, we produced a variant of E. coli catalase-peroxidase (KatG) lacking its C-terminal domain ( ... A soluble, well-behaved KatGNterm, was produced; however, it had neither catalase nor peroxidase activity. Far-UV CD and UV- ...
On the contrary, Catalase (CAT) gene expression was the highest in the susceptible, cv. Spunta, and was the lowest in the ... Meanwhile, gene expression of related enzymes the RT-PCR was used. At zero time, the relatively highly resistant potato ... On the contrary, catalase showed the highest activity values in the susceptible, cv. Spunta, while, in relatively highly ... polyphenol oxidase and catalase. Peroxidase showed maximum activity 0.488 min-1·g-1 early at 12 h after pathogen ...
Recombinant Expression and Mutagenesis Studies of the Catalase with Oxidase Activity from Scytalidium Thermophilum ... Gene Product Annotation Gene Ontology Consortium Homepage. Chains. Polymer. Molecular Function. Biological Process. Cellular ... Crystal structure, recombinant expression and mutagenesis studies of the bifunctional catalase-phenol oxidase from Scytalidium ...
... gene is associated with the development of essential hypertension (EH). SUBJECTS AND METHODS The investigation enrolled 2,339 ... Association of the -844G,A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers].. * ... AIM To investigate whether the functionally relevant -844G,A promotor polymorphism in the catalase (CAT) gene is associated ... article{Bushueva2016AssociationOT, title={[Association of the -844G>A polymorphism in the catalase gene with the increased risk ...
Catalase HPII. A, B, C, D. 753. Escherichia coli. Mutation(s): 1 Gene Names: katE. EC: 1.11.1.6. ... An electrical potential in the access channel of catalases enhances catalysis. Chelikani, P., Carpena, X., Fita, I., Loewen, P. ... Substrate H2O2 must gain access to the deeply buried active site of catalases through channels of 30-50 A in length. The most ... Substrate H2O2 must gain access to the deeply buried active site of catalases through channels of 30-50 A in length. The most ...
Catalase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Summaries for CAT Gene Entrez Gene Summary for CAT Gene. * This gene encodes catalase, a key antioxidant enzyme in the bodies ... Aliases for CAT Gene Aliases for CAT Gene. * Catalase 2 3 3 5 ... CAT Gene(Protein Coding) Catalase. GCID:. GC11P034460 GIFtS:. ... Domains & Families for CAT Gene Protein Domains for CAT Gene. InterPro:. * Catalase_immune_responsive ...
Catalase from bovine liver for your research needs. Find product specific information including CAS, MSDS, protocols and ... Catalase acts as a natural antioxidant to study the roles of reactive oxygen species in gene expression and apoptosis. It has ... Catalase from bovine liver aqueous suspension, 10,000-40,000 units/mg protein Synonym: H2O2:H2O2 oxidoreductase ... 1.11.1.6 Catalase, 1.x.x.x Oxidoreductases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates ...
... dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene ... Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings Microbiology. 1999 Nov;145 ( Pt 11): ... Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide ... increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 ...
Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility to ... Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility to ... Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility to ... T1 - Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility ...
In this study we investigate the mechanism by which OxyR finely regulates the catalase gene (kat) in Neisseria meningitidis. ... OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms.. Ieva R ... Detailed transcriptional analyses show that catalase is transcribed from a single promoter that is induced by H(2)O(2) in an ... This direct double-edged mechanism may ensure tight regulatory control of kat expression ensuring catalase is synthesized only ...
Real time PCR analysis showed different expression pattern for catalase and metallothionein encoded genes. Catalase gene ... In this research the gene expression pattern of Catalase and Metallothionein was studied in response to drought stress ... Whereas, Moghan cultivar showed most transcription for both genes at -8 bar treatment. Overall gene activities, content of ... Catalase and Metallothionein genes have a crucial role to mope the hydrogen peroxide (H2O2) resulting reducing oxidative damage ...
mRNA accumulation of two catalase genes, CAT2 and CAT3, in the higher plant, Arabidopsis thaliana, responds to organ-specific, ... Regulation of Arabidopsis Catalase Gene Expression by Light and the Circadian Clock A Thesis Submitted to the Faculty in ... Regulation of Arabidopsis Catalase Gene Expression by Light and the Circadian Clock A Thesis Submitted to the Faculty in ... Regulation of arabidopsis catalase gene expression by light and the circadian clock. ...
Two highly divergent genes, Cat1 and Cat2, were isolated and characterized. Cat1 codes for a putative 566-amino-acid catalase ... Cat2 codes for a putative catalase subunit of 745 amino acids and belongs to a different gene family coding for the large- ... Identification of two highly divergent catalase genes in the fungal tomato pathogen, Cladosporium fulvum. ... A search for an extracellular catalase was unproductive. The Cat1 and Cat2 genes showed differential expression, with the Cat1 ...
... revealed a close association between the occurrence of EHEC-haemolysin and the katP gene in Shiga-like-toxin-producing E. coli ... EHEC-specific catalase-peroxidase activity was detected primarily in the periplasm in strain EDL 933. The newly discovered ... EHEC catalase-peroxidase activities were investigated in cytoplasmic and periplasmic crude extracts as well as in culture ... This putative protein was found to be highly homologous to members of the bacterial bifunctional catalase-peroxidase family. ...
Mouse Monoclonal Anti-Catalase Antibody (OTI1B8) [Alexa Fluor® 647]. Validated: WB, Flow, ICC/IF, IHC. Tested Reactivity: Human ... Bioinformatics Tool for Catalase Antibody (NBP2-70342AF647). Discover related pathways, diseases and genes to Catalase Antibody ... Catalase Antibody (OTI1B8) [Alexa Fluor® 647] Summary. Immunogen. Full length recombinant protein of human Catalase (NP_111743 ... Blogs on Catalase. There are no specific blogs for Catalase, but you can read our latest blog posts. ...
  • To counteract the potentially toxic effects of this compound, P. aeruginosa possesses two heme-containing catalases which detoxify hydrogen peroxide. (asm.org)
  • Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. (genecards.org)
  • The most prominent or main channel approaches the active site perpendicular to the plane of the heme and contains a number of residues that are conserved in all catalases. (rcsb.org)
  • Changes in Val169, 8 A from the heme in catalase HPII from Escherichia coli, introducing smaller, larger or polar side chains reduces the catalase activity. (rcsb.org)
  • The heme catalase was purified and characterized, and the encoding gene was cloned. (asm.org)
  • Of these, the Methanosarcinales appear to have the most metabolic capabilities, as evidenced by a larger genome with twice as many open reading frames as other methanogens (see below), by the ability to utilize a broader spectrum of substrates ( 4 ), and by the possession of cytochromes ( 10 , 13 , 19 ) and of other heme-containing proteins such as catalase ( 30 ). (asm.org)
  • Given that only methanogens of the Methanosarcinales are capable of synthesizing heme, it was quite a surprise when Leadbetter and Breznak ( 20 ) reported that they had found catalase-like activity in Methanobrevibacter species that colonize the peripheral microoxic region of the hindgut of termites. (asm.org)
  • This explanation was ruled out, however, by our finding, reported here, that catalase activity in M. arboriphilus strains was dependent on the presence of heme in the growth medium. (asm.org)
  • We present evidence that M. arboriphilus contains a heme catalase which is formed from apoprotein synthesized by the methanogen and hemin taken up from the medium. (asm.org)
  • While the complete mechanism of catalase is not currently known, the reaction is believed to occur in two stages: H2O2 + Fe(III)-E → H2O + O=Fe(IV)-E(.+) H2O2 + O=Fe(IV)-E(.+) → H2O + Fe(III)-E + O2 Here Fe()-E represents the iron center of the heme group attached to the enzyme. (wikipedia.org)
  • Turnover of catalase heme and apoprotein moieties in cotyledons of sunflower seedlings. (biomedsearch.com)
  • The turnover of catalase apoprotein and catalase heme was studied in cotyledons of sunflower (Helianthus annuus L.) seedlings by density labeling of apoprotein and radioactive labeling of heme moieties. (biomedsearch.com)
  • Following isopycnic centrifugation of catalase purified from cotyledons of 5-day-old seedlings, superimposition curve fitting was used to determine the amounts of radioactive heme moieties in native and density-labeled catalase. (biomedsearch.com)
  • Data from these determinations indicated that turnover of catalase heme and apoprotein essentially was coordinate. (biomedsearch.com)
  • It followed from these observations that degradation of catalase apoprotein was slightly faster than that of catalase heme. (biomedsearch.com)
  • A degradation constant for catalase apoprotein of 0.263 per day was determined from the data on heme recycling and the degradation constant of catalase heme determined previously to be 0.205 per day (R Eising, B Gerhardt Plant Physiol 84: 225-232). (biomedsearch.com)
  • mRNA accumulation of two catalase genes , CAT2 and CAT3 , in the higher plant , Arabidopsis thaliana , responds to organ-specific , developmental , temperature , and light signals , as well as to the circadian clock . (dartmouth.edu)
  • Most strikingly , the circadian phases of maximal mRNA abundance for the two CAT genes are distinct , with CAT2 mRNA most abundant in the morning and CAT3 mRNA peaking in the evening . (dartmouth.edu)
  • The Cat1 and Cat2 genes showed differential expression, with the Cat1 mRNA preferentially accumulating in spores and the Cat2 mRNA preferentially accumulating in response to external H2O2. (edu.au)
  • Genes related to pathogenesis varied in temporal expression pattern, mRNA level, and family size between the species. (biomedcentral.com)
  • Similarly, mRNA abundance of the three genes varies among organs. (plantphysiol.org)
  • To identify genes and miRNAs involved in drought-stress responses in tobacco, we performed both mRNA and small RNA sequencing on tobacco leaf samples from the following three treatments: untreated-control (CL), drought stress (DL), and re-watering (WL). (biomedcentral.com)
  • In addition, we observed significant SNP-SNP interactions with synergistic genetic effects in SOD2, SOD3 and CAT genes for Pv and in SOD2 and SOD3 genes for Pf. (elsevier.com)
  • Better diabetes control was found in patients with CC than with TT genotype of SOD2 gene. (beds.ac.uk)
  • Significantly different allele and genotype frequencies of SOD2 gene polymorphism were found among diabetic patients with macroangiopathy and those without it. (beds.ac.uk)
  • SOD2 and catalase combined were also effective. (harvard.edu)
  • Saccharomyces cerevisiae mutants deficient in superoxide dismutase genes ( sod1 D , sod2 D and sod1 D sod2 D mutants) in a stationary phase of growth under high aeration conditions were subjected to H 2 O 2 stress. (scielo.br)
  • The sod2 D mutant demonstrated a similar catalase activity to that of the wild-type without treatment, whilst decreased catalase activity was observed in conditions of low aeration. (scielo.br)
  • Untreated sod1 D sod2 D double mutant cells presented a lower catalase activity. (scielo.br)
  • Catalase levels were higher under high aeration conditions than under microaerophilic conditions, including in sod1 D sod2 D cells that contain less H 2 O 2 , since SOD catalyzes the cleavage of superoxide producing H 2 O 2 and oxygen. (scielo.br)
  • Saccharomyces cerevisiae deficientes nos genes da superóxido dismutase (mutantes sod1 D , sod2 D e sod1 D sod2 D ) cultivados em fase estacionária sob condições de alta aeração foram submetidos ao estresse com peróxido de hidrogênio (H 2 O 2 ). (scielo.br)
  • O mutante sod2 D demonstrou atividade da catalase similar a da cepa selvagem sem tratamento, enquanto foi observado que a atividade da catalase decresceu em condições de baixa aeração. (scielo.br)
  • O duplo mutante sod1 D sod2 D apresentou baixa atividade da catalase mesmo sem tratamento. (scielo.br)
  • Os níveis da catalase foram maiores em condições de alta aeração do que em condições microaerófilas, inclusive o duplo mutante sod1 D sod2 D contém menos H 2 O 2 , visto que, a SOD catalisa a clivagem do superóxido produzindo H 2 O 2 e oxigênio. (scielo.br)
  • The sequence of the promoter region of the gonococcal kat gene is unusual and may explain the extremely high, loosely regulated expression of the gene. (asm.org)
  • One SNP in the promoter region of the catalase gene, rs1001179, which is associated with higher enzyme expression, was significantly underrepresented (p = 0.01, OR 0.38) among patients with moderate to severe RSV bronchiolitis, suggesting a protective effect against disease severity. (utmb.edu)
  • To reduce the accumulation of lactic acid-induced ROS, cytosolic catalase ( CTT1 ) was overexpressed by replacing the native promoter with the strong constitutive TPI1 promoter. (asm.org)
  • Methods and compositions relating to chimeric genes containing (i) a tissue-specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e.g., bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. (freepatentsonline.com)
  • Hypoxic Induction of the Human Erythropoietin Gene: Cooperation between the Promoter and Enhancer, Each of Which Contains Steroid Receptor Response Elements" Molecular and Cellular Biology (1992) 12(12):5373. (freepatentsonline.com)
  • Through searches of the genome of the sea anemone Nematostella vectensis Stephenson, one catalase gene and six SOD family members were identified, including three copper/zinc-containing SODs (CuZnSODs), two manganese-containing SODs (MnSODs) and one copper chaperone of SOD (CCS). (biologists.org)
  • The results of PCR, Southern and Northern hybridization indicated that the bt, hsc70, sod62 and cat78 genes had been inserted into the genome of Chinese cabbage, and expressed. (core.ac.uk)
  • The coding genes have recently been shown to derive from a lateral gene transfer from a (proteo)bacterial genome followed by gene duplication and diversification. (biochemj.org)
  • Human ACOX1 genome location and ACOX1 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Consistent with the absence of peroxisomes in microsporidia, the recently completed genome of the microsporidian Encephalitozoon cuniculi lacks a gene for catalase, the major enzymatic marker for the organelle. (mendeley.com)
  • We show, however, that the genome of the microsporidian Nosema locustae, in contrast to that of E. cuniculi, encodes a group II large-subunit catalase. (mendeley.com)
  • The catalase gene is adjacent to a large region of the genome that appears to be far less compact than is typical of microsporidian genomes, a characteristic which may make this region more amenable to the insertion of foreign genes. (mendeley.com)
  • A novel protocol for full-length Mycobacterium tuberculosis gene analysis of first- and second-line drug resistance was developed using the Ion Torrent Personal Genome Machine (PGM). (asm.org)
  • When cloned into a catalase-deficient mutant of Escherichia coli (UM255), the recombinant P. aeruginosa KatB was expressed (229 U/mg) and afforded this strain resistance to hydrogen peroxide nearly equivalent to that of the wild-type E. coli strain (HB101). (asm.org)
  • The kat gene was then successfully subcloned into both pUC8 and pGB2, transformed into Escherichia coli, and shown to complement the E. coli katE mutants UM2 and UMRl. (asm.org)
  • Its similarity to prokaryotic catalases is greater than to other fungal catalases. (nih.gov)
  • Homology-based screens were performed to identify catalase genes in the fungal tomato pathogen Cladosporium fulvum. (edu.au)
  • Surprisingly, phylogenetic analyses indicate that the N. locustae catalase is not specifically related to fungal homologs, as one would expect, but is instead closely related to proteobacterial sequences. (mendeley.com)
  • Catalase from bovine liver is a tetramer consisting of 4 equal subunits each with a 60 kDa molecular weight. (sigmaaldrich.com)
  • Catalase and Metallothionein genes expression analysis in wheat cultivars under drought stress condition', Journal of Plant Molecular Breeding , 1(2), pp. 54-68. (jpmb-gabit.ir)
  • Catalase in turn converts hydrogen peroxide to molecular oxygen and water. (biologists.org)
  • In 1937 catalase from beef liver was crystallised by James B. Sumner and Alexander Dounce and the molecular weight was found in 1938. (wikipedia.org)
  • In this report, we have made use of a transgenic mouse model in which catalase is overexpressed and targeted to mitochondria (mCAT) to clearly define cardiac aging phenotypes in a murine model of aging and investigate their plausible molecular mechanisms, to investigate the impact of reductions in mitochondrial ROS on cardiac aging, and to investigate the impact of cardiac aging on all-cause mortality. (ahajournals.org)
  • Understanding the molecular basis of plant-pathogen interactions increases our ability to deploy selected plant resistance genes from virtually any plant. (apsnet.org)
  • Hypoxia-Regulatory Elements of the Human Vascular Endothelial Growth Factor Gene," Cellular and Molecular Biology Research 40(1):35-39 (1994). (freepatentsonline.com)
  • Corpus-, document-, and word-level LDA parameters were combined with terms from the Gene Ontology to enhance the explanatory value of the CGC LDA model, and to suggest additional candidates for age-related genes. (biomedcentral.com)
  • Recent data suggest that at low concentrations hydrogen peroxide acts as a cellular messenger in insulin signaling, whereas at high concentrations it is toxic, particularly in pancreatic cells, which are catalase poor. (diabetesjournals.org)
  • Hypoxic conditions also increased the amounts of cellular procaspase-3 and catalase as well as phosphorylation of the pro-survival kinase Akt, but not Erk1/2 or STAT5. (biologists.org)
  • Cat2 codes for a putative catalase subunit of 745 amino acids and belongs to a different gene family coding for the large-subunit catalases similar to ones found in bacteria and filamentous fungi. (edu.au)
  • Abstract We report the first description of a rare catalase -negative strain of Staphylococcus aureus in Chile . (bvsalud.org)
  • one catalase molecule can convert millions of hydrogen peroxide molecules to water and oxygen each second. (wikipedia.org)
  • These genes produce the molecule quinolone which then regulates operons 1 and 2 of phzRABCDEFG which are key to the synthesis of phenazine. (wikipedia.org)
  • Ideally a plant could be engineered to show an incompatible reaction with an invading pathogen that leads to localized cell death through HR by transforming it with an appropriate plant resistance gene or an elicitor molecule. (apsnet.org)
  • Whole transcriptome sequencing of Symbiodinium cells on days 4, 19, and 28 were used to identify differentially expressed genes under thermal stress. (frontiersin.org)
  • Consistent with previous studies of Symbiodinium gene expression, fold changes across the transcriptome were low, with 92.49% differentially expressed genes at ≤2-fold change. (frontiersin.org)
  • In total, we identified 798 differentially expressed genes (DEGs) between the DL and CL (DL vs. CL) treatments and identified 571 DEGs between the WL and DL (WL vs. DL) treatments. (biomedcentral.com)
  • RNA sequencing analyses showed that flies reared on an SD induced significant changes in the expression levels of genes associated with specific metabolic as well as cell growth and death pathways. (biomedcentral.com)
  • The structural gene for the catalase of Neisseria gonorrhoeae was cloned into a Kat- strain of that organism by using a recombinant vector derived from one of the beta-lactamase-specifying plasmids found in that organism. (asm.org)