Catabolite repression. Medical search

Process by which micro-organisms adapt quickly to a preferred rapidly-metabolizable intermediate through the inhibition or repression of genes related to CATABOLISM of less preferred source(s).

The interference in synthesis of an enzyme due to the elevated level of an effector substance, usually a metabolite, whose presence would cause depression of the gene responsible for enzyme synthesis.

A family of galactoside hydrolases that hydrolyze compounds with an O-galactosyl linkage. EC 3.2.1.-.

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.

Proteins found in any species of bacterium.

A species of gram-positive bacteria that is a common soil and water saprophyte.

A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.

An enzyme that catalyzes the first step of histidine catabolism, forming UROCANIC ACID and AMMONIA from HISTIDINE. Deficiency of this enzyme is associated with elevated levels of serum histidine and is called histidinemia (AMINO ACID METABOLISM, INBORN ERRORS).

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A urea hydantoin that is found in URINE and PLANTS and is used in dermatological preparations.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.

Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

The functional hereditary units of BACTERIA.

An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.

An enzyme that catalyzes the conversion of 4,5-dihydro-4-oxo-5-imidazolepropanoate to urocanate and water. EC 4.2.1.49.

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.

The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.

A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.

An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.

Cell surface proteins that bind cyclic AMP with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized cyclic AMP receptors are those of the slime mold Dictyostelium discoideum. The transcription regulator CYCLIC AMP RECEPTOR PROTEIN of prokaryotes is not included nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.

Enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. EC 4.3.1.

Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.

A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)

A family of transcription factors that contain two ZINC FINGER MOTIFS and bind to the DNA sequence (A/T)GATA(A/G).

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.

A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)

Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.

The functional hereditary units of FUNGI.

A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.

A glycoside hydrolase found primarily in PLANTS and YEASTS. It has specificity for beta-D-fructofuranosides such as SUCROSE.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Proteins found in any species of fungus.

An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.

Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.

A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.

An enzyme that catalyzes the conversion of acetoin to diacetyl in the presence of NAD.

A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Proteins obtained from ESCHERICHIA COLI.

A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC 2.7.1.2.

Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.

In eukaryotes, a genetic unit consisting of a noncontiguous group of genes under the control of a single regulator gene. In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of several OPERONS.

A rod-shaped bacterium isolated from milk and cheese, dairy products and dairy environments, sour dough, cow dung, silage, and human mouth, human intestinal contents and stools, and the human vagina.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.

Enzymes that catalyze the interconversion of aldose and ketose compounds.

An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-galactose. Galactosamine can also act as the acceptor. A deficiency of this enzyme results in GALACTOSEMIA. EC 2.7.1.6.

The regulatory elements of an OPERON to which activators or repressors bind thereby effecting the transcription of GENES in the operon.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

The in vitro fusion of GENES by RECOMBINANT DNA techniques to analyze protein behavior or GENE EXPRESSION REGULATION, or to merge protein functions for specific medical or industrial uses.

An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.

Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.

A pentose active in biological systems usually in its D-form.

A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE.

The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

Enzymes that hydrolyze O-glucosyl-compounds. (Enzyme Nomenclature, 1992) EC 3.2.1.-.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).

An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.

A group of enzymes that catalyzes the transfer of a phosphate group onto a nitrogenous group acceptor. EC 2.7.3.

A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 catalyzes the endo-hydrolysis of 1,4-beta-D-xylosidic linkages; EC 3.2.1.32 catalyzes the endo-hydrolysis of 1,3-beta-D-xylosidic linkages; EC 3.2.1.37 catalyzes the exo-hydrolysis of 1,4-beta-D-linkages from the non-reducing termini of xylans; and EC 3.2.1.72 catalyzes the exo-hydrolysis of 1,3-beta-D-linkages from the non-reducing termini of xylans. Other xylosidases have been identified that catalyze the hydrolysis of alpha-xylosidic bonds.

An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 2.7.1.30.

Nucleic acid sequences involved in regulating the expression of genes.

A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.

A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.

Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.

Life or metabolic reactions occurring in an environment containing oxygen.

Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.

An enzyme in the tryptophan biosynthetic pathway. EC 4.1.1.48.

A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

An essential amino acid that is required for the production of HISTAMINE.

A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)

Any method used for determining the location of and relative distances between genes on a chromosome.

A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.

The rate dynamics in chemical or physical systems.

A species of bacteria whose spores vary from round to elongate. It is a common soil saprophyte.

A widely used industrial solvent.

Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.

Bacterial repressor proteins that bind to the LAC OPERON and thereby prevent the synthesis of proteins involved in catabolism of LACTOSE. When lactose levels are high lac repressors undergo an allosteric change that causes their release from the DNA and the resumption of lac operon transcription.

The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.

An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.

Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.

Deoxyribonucleic acid that makes up the genetic material of fungi.

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.

A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.

Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.

Galactosides in which the oxygen atom linking the sugar and aglycone is replaced by a sulfur atom.

Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.

A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).

Enzymes which catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in XYLANS.

A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.

A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.

An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.

An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.

An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.

Deletion of sequences of nucleic acids from the genetic material of an individual.

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.

A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.

A family of compounds containing an oxo group with the general structure of 1,5-pentanedioic acid. (From Lehninger, Principles of Biochemistry, 1982, p442)

A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.

The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.

A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that causes vascular wilts on a wide range of plant species. It was formerly named Erwinia chrysanthemi.

A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

Transport proteins that carry specific substances in the blood or across cell membranes.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)

The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.

A species of gram-negative, aerobic bacteria that causes formation of root nodules on some, but not all, types of sweet clover, MEDICAGO SATIVA, and fenugreek.

A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.

A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.

Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.

A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The turning off of GENETIC TRANSCRIPTION in certain regions of CHROMATIN without changes in the DNA sequence. Typically epigenetic repression is a way that developmental changes are programmed at the cellular level.

A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.

Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.

Vertical transmission of hereditary characters by DNA from cytoplasmic organelles such as MITOCHONDRIA; CHLOROPLASTS; and PLASTIDS, or from PLASMIDS or viral episomal DNA.

Bacterial proteins that are used by BACTERIOPHAGES to incorporate their DNA into the DNA of the "host" bacteria. They are DNA-binding proteins that function in genetic recombination as well as in transcriptional and translational regulation.

Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.

Transcriptional analysis of differential carbohydrate utilization by Clostridium acetobutylicum. (1/31)

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Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy. (2/31)

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Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass. (3/31)

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Escherichia coli mhpR gene expression is regulated by catabolite repression mediated by the cAMP-CRP complex. (4/31)

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Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. (5/31)

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Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria. (6/31)

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cAMP receptor protein (CRP) positively regulates the yihU-yshA operon in Salmonella enterica serovar Typhi. (7/31)

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Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus. (8/31)

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CS1 maint: discouraged parameter (link) Stülke J, Hillen W. (1999). "Carbon catabolite repression in bacteria". Current Opinion ... is required for the catabolite activator protein (CAP) to bind to DNA and activate the transcription of the lac operon, which ...

https://en.wikipedia.org/wiki/Diauxie

Two puzzles of catabolite repression relate to how cAMP levels are coupled to the presence of glucose, and secondly, why the ... Catabolite repression Griffiths, Anthony J.F.; Wessler, Susan R.; Carroll, Sean B.; Doebley, John (2015). An Introduction to ... Görke B, Stülke J (August 2008). "Carbon catabolite repression in bacteria: many ways to make the most out of nutrients". ... Binding of RNA polymerase to the promoter is aided by the cAMP-bound catabolite activator protein (CAP, also known as the cAMP ...

https://en.wikipedia.org/wiki/Lac_operon

4. Catabolite repression[1] When a microorganism is provided with a rapidly metabolizable carbon-energy source such as glucose ... A powerful method of overcoming the catabolite repression in the enzyme biosynthesis is a fed-batch culture in which glucose ... This phenomenon is known as catabolite repression. Many enzymes, especially those involved in catabolic pathways, are subject ... Substrate limitation also allows the metabolic control, to avoid osmotic effects, catabolite repression and overflow metabolism ...

https://en.wikipedia.org/wiki/Fed-batch_culture

Harchand, R. K.; Singh, S (1994). "Catabolite repression of cellulase biosynthesis in Streptomyces albaduncus". Journal of ...

https://en.wikipedia.org/wiki/Streptomyces_albaduncus

Graham, I. A.; Denby, K. J.; Leaver, C. J. (1994). "Carbon Catabolite Repression Regulates Glyoxylate Cycle Gene Expression in ...

https://en.wikipedia.org/wiki/Ian_A._Graham

malT is regulated by catabolite repression via the catabolite activator protein. Genes under the control of malT include ATP- ...

https://en.wikipedia.org/wiki/Mal_regulon

Vargas M; Noll KM (January 1996). "Catabolite repression in the hyperthermophilic bacterium Thermotoga neapolitana is ...

https://en.wikipedia.org/wiki/Thermotoga_neapolitana

... is a small RNA found in Pseudomonas bacteria, which acts as a global regulator of carbon catabolite repression. In P. ... Sonnleitner E, Abdou L, Haas D (December 2009). "Small RNA as global regulator of carbon catabolite repression in Pseudomonas ... Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression ... and catabolite repression is high. In the presence of poor sources of carbon, such as mannitol, CrcZ expression is high, ...

https://en.wikipedia.org/wiki/CrcZ

... with Catabolite repression (SOC) is SOB with added glucose. (Figures in parentheses are the masses required ...

https://en.wikipedia.org/wiki/Super_Optimal_Broth

Environmental stresses such as antibiotics and catabolite repression can influence toxin expression. The tcdA and tcdB genes ...

https://en.wikipedia.org/wiki/Clostridium_difficile_toxin_A

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization ... Zhang L, Chiang WC, Gao Q, Givskov M, Tolker-Nielsen T, Yang L, Zhang G (December 2012). "The catabolite repression control ... Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression ... "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6): e1004440. doi ...

https://en.wikipedia.org/wiki/Crc_(protein)

Some of them, including UV5, has lost catabolite repression at the CAP site. Development into cloning vectors is known since ... Silverstone, AE; Arditti, RR; Magasanik, B (July 1970). "Catabolite-insensitive revertants of lac promoter mutants". ...

https://en.wikipedia.org/wiki/LacUV5

Examining Escherichia coli glycolytic pathways, catabolite repression, and metabolite channeling using Δ pfk mutants. ...

https://en.wikipedia.org/wiki/Glycolysis

Later, she discovered another factor that boosts catabolite repression (catabolite modulator factor, or CMF). Ullmann ... In 1967 she showed that cAMP reverses catabolite repression in the bacterium E. coli. ...

https://en.wikipedia.org/wiki/Agnes_Ullmann

Peter GJ, Düring L, Ahmed A (March 2006). "Carbon catabolite repression regulates amino acid permeases in Saccharomyces ... "Sustained translational repression by eIF2α-P mediates prion neurodegeneration". Nature. 485 (7399): 507-11. Bibcode:2012Natur. ... "PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR". Nature. 442 (7104): 779-85. Bibcode: ...

https://en.wikipedia.org/wiki/MTOR

"Transcription analysis of lignocellulolytic enzymes of Penicillium decumbens 114-2 and its catabolite-repression-resistant ...

https://en.wikipedia.org/wiki/Penicillium_decumbens

Nakashima, Nobutaka; Tamura, Tomohiro (1 July 2012). "A new carbon catabolite repression mutation of Escherichia coli, mlc∗, ...

https://en.wikipedia.org/wiki/Butanol_fuel

Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression. First ...

https://en.wikipedia.org/wiki/Sucrose_phosphorylase

Lee JH, Dobrogosz WJ (May 1983). "Effects of aerobic and anaerobic shock on catabolite repression in cyclic AMP suppressor ... In particular, his research focused on the phenomenon of catabolite repression, a regulatory system involving interactions of ... cyclic AMP, the catabolite repressor protein (CRP) complex, and the lac operon and other inducible systems in bacteria. The ...

https://en.wikipedia.org/wiki/Walter_Dobrogosz

Galactose is an alternate carbon source to the preferable glucose . The cAMP/CRP catabolite repression regulator is most likely ... 5. El Qaidi, S., Allemand, J.O., and Plumbridge, J. (2009). Repression of galP, the galactose transporter in Escherichia coli, ... so both of these proteins are required for repression (11). cAMP is what modulates CRP at the promoter. The cAMP-CRP complex ... a protein from the nagC gene which is responsible for N-acetylglucosamine repression (5). This study suspects that NagC ...

https://en.wikipedia.org/wiki/GalP_(protein)

Carbon Catabolite Repression-Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. ...

https://en.wikipedia.org/wiki/CCR4-Not

2004). "HPr kinase/phosphorylase, a Walker motif A-containing bifunctional sensor enzyme controlling catabolite repression in ...

https://en.wikipedia.org/wiki/Morpheein

... which results in thn gene repression in catabolite repression conditions. EcpR1 sRNA RcsR1 small RNA Corbino KA, Barrick JE, ... catabolite repression conditions). This phenotype is due to the release of the negative effect of suhB on ThnR translation. Hfq ... a small non-coding RNA involved in catabolite repression of tetralin degradation genes in Sphingopyxis granuli strain TFA". ...

https://en.wikipedia.org/wiki/SuhB

She found that the catabolite repression control protein, which regulates carbon metabolism, is essential for biofilm formation ...

https://en.wikipedia.org/wiki/Karine_A._Gibbs

"The Base-Pairing RNA Spot 42 Participates in a Multioutput Feedforward Loop to Help Enact Catabolite Repression in Escherichia ... The direct responsiveness of Spot 42 levels to glucose and cAMP is due to repression of spf expression by a cAMP-CRP (cAMP- ...

https://en.wikipedia.org/wiki/Spot_42_RNA

Vijay Kumar, N.; Rangarajan, P. N. (2011). "Catabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein ... Rabies vaccine Foot-and-mouth disease Plasmodium falciparum Catabolite repression India portal Medicine portal Long link - ...

https://en.wikipedia.org/wiki/P._N._Rangarajan

This explains why, when grown with glucose, E. coli will lose the ability to internalize AI-2 (because of catabolite repression ...

https://en.wikipedia.org/wiki/Quorum_sensing

... biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression ...

https://en.wikipedia.org/wiki/Changestat

... most commonly used lac or lac-derived promoters are based on the lacUV5 mutant which is insensitive to catabolite repression. ... PMID 6337371.CS1 maint: multiple names: authors list (link) Silverstone AE, Arditti RR, Magasanik B (1970). "Catabolite- ...

https://en.wikipedia.org/wiki/Expression_vector

Boris Magasanik (1993) For his contributions to our understanding of catabolite repression, amino acid metabolism, and ...

https://en.wikipedia.org/wiki/Selman_A._Waksman_Award_in_Microbiology

nitrogen catabolite activation of transcription from RNA polymerase II promoter. • negative regulation of tumor necrosis factor ... "Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids". ...

https://en.wikipedia.org/wiki/Farnesoid_X_receptor

... β-galactosidase is under repression due to the effect of catabolite repression caused by glucose. The catabolite repression in ... Carbon catabolite repression, or simply catabolite repression, is an important part of global control system of various ... Note that E. coli has a similar cAMP-independent catabolite repression mechanism that utilizes a protein called catabolite ... Catabolite repression was extensively studied in Escherichia coli. E. coli grows faster on glucose than on any other carbon ...

https://en.wikipedia.org/wiki/Catabolite_repression

... super optimal broth with catabolite repression), colonies were patched onto selective plates using a toothpick and incubated at ...

https://en.wikipedia.org/wiki/No-SCAR_(Scarless_Cas9_Assisted_Recombineering)_Genome_Editing

... because the invertase is insensitive to catabolite repression by glucose, and because the activity of the glucose uptake system ...

https://en.wikipedia.org/wiki/Thermomyces_lanuginosus

... presence of glucose or reversed off by the addition of glucose in the culture medium which is a form of catabolite repression. ...

https://en.wikipedia.org/wiki/Arabinose

... a variation of Cardiopulmonary Resuscitation Carbon catabolite repression, part of the adaptive metabolic control system ...

https://en.wikipedia.org/wiki/CCR

Catabolite repression, and the presence of β-glucan-hydrolyzing enzymes that attack botryosphaeran during the fermentation ...

https://en.wikipedia.org/wiki/Botryosphaeran

... while it is repressed by nitrate and subject to CRP-mediated catabolite repression. DcuC family Zientz E, Six S, Unden G ( ...

https://en.wikipedia.org/wiki/Dcu_family

Catabolite repression has also been observed in E.coli in the presence of other non-glucose sugars, such as arabinose and ... In E. coli, glucose catabolite repression is regulated by the phosphotransferase system, a multi-protein phosphorylation ... bacteria will often consume the sugars sequentially through a process known as catabolite repression. By repressing the ...

https://en.wikipedia.org/wiki/Escherichia_coli

... catabolite repression control protein Criminal record check Cross Racing Championship Extreme 2005 (CRC 2005), a car-racing ...

https://en.wikipedia.org/wiki/CRC

https://en.wikipedia.org/wiki/Catabolite_repression

Two cyclic AMP-independent catabolite repression mechanisms are currently under study. One such mechanism, found … ... only one mechanism of catabolite repression in bacteria, a mechanism dependent on the cyclic AMP receptor protein of ... When catabolites bind to Cra, Cra dissociates from the DNA causing catabolite activation and catabolite repression, ... DNA binding of the complex in turn promotes catabolite repression or catabolite activation, depending on the target operon. The ...

https://pubmed.ncbi.nlm.nih.gov/9026456/?dopt=Abstract

... in both catabolite repression and transient repression. These results, combined with extensive genetic and in vitro studies ... Adenosine 3:5-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. W Epstein, L B Rothman-Denes, ... Adenosine 3:5-cyclic monophosphate as mediator of catabolite repression in Escherichia coli ... Adenosine 3:5-cyclic monophosphate as mediator of catabolite repression in Escherichia coli ...

https://www.pnas.org/content/72/6/2300?ijkey=6c121732e8c29764f247515f028986b3b9795145&keytype2=tf_ipsecsha

Regulatory exaptation of the catabolite repression protein (Crp)-cAMP system in Pseudomonas putida.. Milanesio P1, Arce- ... encoding the catabolite repression protein, Crp) and cyaA (adenylate cyclase) of Escherichia coli. The levels of cAMP formed by ...

https://www.ncbi.nlm.nih.gov/pubmed/21281420

Unlike catabolite repression by glucose, no small molecular weight compound is involved in U.V. light induced inhibition of the ... Unlike catabolite repression by glucose, no small molecular weight compound is involved in U.V. light induced inhibition of the ... ETDEWEB / Search Results / Mechanism of ultraviolet light induced catabolite repression of L-arabinose isomerase ... An attempt has been made to find out how U.V. irradiation of E.coli B/r cells causes catabolite repression to inhibit L- ...

https://www.osti.gov/etdeweb/biblio/6096134

One form of catabolite repression (CR) in the Gram-positive genus, Bacillus, is mediated by a cis-acting element (CRE). We use ... Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria.. Hueck CJ1, Hillen W, Saier MH Jr. ...

https://www.ncbi.nlm.nih.gov/pubmed/7855437?dopt=Abstract

This gene is subject to catabolite repression; the ACO1 mRNA level is further reduced when glutamate is supplied with glucose. ... We identified a gene required for wild-type expression of ACO1 only under catabolite repression conditions. Sequencing of the ... The Saccharomyces cerevisiae RTG2 Gene Is a Regulator of Aconitase Expression Under Catabolite Repression Conditions. Christian ... The Saccharomyces cerevisiae RTG2 Gene Is a Regulator of Aconitase Expression Under Catabolite Repression Conditions. Christian ...

http://www.genetics.org/content/144/3/893

Characterization of Escherichia coli Flagellar Mutants That are Insensitive to Catabolite Repression. Michael Silverman, Melvin ... Their synthesis was depressed in strains grown under conditions of catabolite repression. The presence of the cfs mutation ... In Escherichia coli, the synthesis of the flagellar organelle is sensitive to catabolite repression. Synthesis requires the ... Characterization of Escherichia coli Flagellar Mutants That are Insensitive to Catabolite Repression ...

https://jb.asm.org/content/120/3/1196?ijkey=5cbed8efef201ff4da737700950c8ab7607726d1&keytype2=tf_ipsecsha

Carbon catabolite repression (CCR) is a strategy to ensure optimal carbon metabolism. In this study, we employed Sulfolobus ... Mechanism of Catabolite Repression In The Archaeon Sulfolobus solfataricus. Yukari Maezato, University of Nebraska - Lincoln. ... Carbon catabolite repression (CCR) is a strategy to ensure optimal carbon metabolism. In this study, we employed Sulfolobus ... Maezato, Yukari, "Mechanism of Catabolite Repression In The Archaeon Sulfolobus solfataricus" (2012). ETD collection for ...

https://digitalcommons.unl.edu/dissertations/AAI3512072/

Crystal Structure at 1.8 A of the Bacillus Subtil Catabolite Bacillus Subtilis Catabolite Repression Containing Protein (Crh) ... CRYSTAL STRUCTURE AT 1.8 ANGSTROMS OF SELENO METHIONYLED CRH, THE BACILLUS SUBTILIS CATABOLITE REPRESSION CONTAINING PROTEIN ...

http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1MO1

Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei María José ... 1997) Catabolite repression in Lactobacillus casei ATCC 393 is mediated by CcpA. J. Bacteriol. 179:6657-6664. ... Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei ... Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei ...

https://jb.asm.org/content/181/13/3928?ijkey=3624b93e6e38167df0de432dc41b623f3cbd4cb0&keytype2=tf_ipsecsha

Recombinant CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) Protein (His tag). Species: Xenopus laevis. Source: Yeast. Order ... CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) Background Recommended name: Nocturnin.. Alternative name(s): Rhythmic ... CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) show synonyms for this antigen * CCR4L ... CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) (AA 1-388) protein (His tag). Details for Product No. ABIN1477485 ...

https://www.antibodies-online.com/protein/1477485/CCR4+Carbon+Catabolite+Repression+4-Like+CCRN4L+AA+1-388+protein+His+tag/

... insensitive to catabolite repression, and (b) that transient repression is an exceptionally severe form of catabolite ... M. D. Yudkin; Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ... All of the 19 p−recombinants tested proved to suffer no transient repression, whereas all of the eight p+recombinants tested ...

https://portlandpress.com/biochemj/article-abstract/123/4/579/7217/Effect-of-point-mutations-in-the-lac-promoter-on?redirectedFrom=fulltext

Seidl, K; Bischoff, M; Berger-Bächi, B (2008). CcpA mediates the catabolite repression of tst in Staphylococcus aureus. ... We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst ... We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst ... whereas glucose repression was abolished in the corresponding DeltaccpA mutant. Stabilizing the pH ruled out a pH effect due to ...

http://www.zora.uzh.ch/id/eprint/3953/

Isolation of the MIG1 gene from Candida albicans and effects of its disruption on catabolite repression. ...

https://digital.csic.es/handle/10261/24308

One of the best characterized of these is the process by which the PTS regulates inducer uptake and catabolite repression. ... Although the PTS-mediated regulation of cyclic AMP synthesis (catabolite repression) is not as well defined from a mechanistic ... Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial ... Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial ...

https://mmbr.asm.org/content/53/1/109?ijkey=4356e417fd953522191ff0d474b94f9cabb733ce&keytype2=tf_ipsecsha

Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in ... Nitrogen catabolite repression (NCR) restrains the yeasts capacity to use poor nitrogen sources when rich ones are available. ... The Yeast GATA Factor Gat1 Occupies a Central Position in Nitrogen Catabolite Repression-Sensitive Gene Activation. Isabelle ... Saccharomyces cerevisiae GATA sequences function as TATA elements during nitrogen catabolite repression and when Gln3p is ...

https://mcb.asm.org/content/29/13/3803?ijkey=270c2d1718f84a70442d6ae98d74939520dadb9c&keytype2=tf_ipsecsha

Many microbial genes are subject to carbon catabolite repression (CCR), the repression in the presence of a preferred carbon ... The creC carbon catabolite repression gene of Aspergillus nidulans encodes a protein containing WD40 repeats. Richard B. Todd, ...

https://www.aspergillus.org.uk/content/crec-carbon-catabolite-repression-gene-aspergillus-nidulans-encodes-protein-containing-wd40

Catabolite repression was thoroughly studied in the bacterium Escherihia coli and, though not so well, in the yeast ... Yarrowia Lipolytica Yeast Possesses An Atypical Catabolite Repression. Catabolite repression was thoroughly studied in the ... Glucose Repression (Catabolite Repression) in Yeast. In: Yeast Sugar Metabolism. Biochemistry, Genetics, Biotechnology and ... but there are different circuits of repression for different groups of genes (2). Catabolite repression allows the respective ...

http://www.jbsdonline.com/c4304/c4306/iyarrowia-lipolytica-iyeast-possesses-atypical-catabolite-repression-p17970.html

The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli. J ... 1. The specific role of the lac repressor (i-gene product) in transient catabolite repression evoked by the introduction of ... The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli ... The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli ...

http://www.biochemj.org/content/106/2/339

Nitrogen catabolite repression (NCR) refers to this selection mechanism. All known nitrogen catabolite pathways are regulated ... Nitrogen catabolite repression (NCR) refers to this selection mechanism [1, 2]. More specifically, NCR inhibits the ... Yeast Gene Variable Selection Method Bioinformatics Study Good Nitrogen Source Nitrogen Catabolite Repression ... Machine learning techniques to identify putative genes involved in nitrogen catabolite repression in the yeast Saccharomyces ...

https://rd.springer.com/article/10.1186/1753-6561-2-s4-s5

... insensitive to catabolite repression, and (b) that transient repression is an exceptionally severe form of catabolite ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ...

http://www.biochemj.org/content/123/4/579

"Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae, Russian Journal of ... Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae. Padkina, M.; Tarasov ... Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae. Effect of the pho85 ... lp/springer_journal/effect-of-the-pho85-mutation-on-catabolite-repression-of-the-cit1-gene-6C0GSS0Klj ...

https://www.deepdyve.com/lp/springer_journal/effect-of-the-pho85-mutation-on-catabolite-repression-of-the-cit1-gene-6C0GSS0Klj

A constitutive catabolite repression mutant of a recombinant Saccharomyces cerevisiae strain improves xylose consumption during ... The aim of this work was to develop constitutive catabolite repression mutants in a xylose-utilising recombinant Saccharomyces ... Constitutive catabolite repressed strain YCR17 grew four-fold better on xylose in aerobic conditions than the control strain ... This study shows that a constitutive catabolite repressed mutant could be used to enhance the xylose consumption rate even in ...

http://scholar.sun.ac.za/handle/10019.1/11872

Repression in E. coli is partially relieved if cAMP is bound to the cAMP catabolite… 📐 📓 📒 📝 ... catabolite repression - catabolite repression. См. глюкозный эффект. (Источник: «Англо русский толковый словарь генетических ... Repression in E. coli is partially relieved if cAMP is bound to the cAMP-catabolite activator protein (cAMP receptor protein; ... catabolite repression. Inducible enzyme systems in some microorganisms (such as the lac operon) that are repressed when a more ...

https://enacademic.com/dic.nsf/en_molecular_biology/1110/catabolite

Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR. Proceedings of the ... Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR. / Sievert, Christian ... title = "Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR", ... T1 - Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR ...

https://asu.pure.elsevier.com/en/publications/experimental-evolution-reveals-an-effective-avenue-to-release-cat

"Catabolite Repression and Induction of Beta-galactosidase Synthesis Lab Report", n.d.). Catabolite Repression and Induction of ... Catabolite Repression and Induction of Beta-Galactosidase Synthesis Lab Report). Catabolite Repression and Induction of Beta- ... The paper "Catabolite Repression and Induction of Beta-galactosidase Synthesis" demonstrates both catabolite repression and ... Extract of sample "Catabolite Repression and Induction of Beta-galactosidase Synthesis". Download file to see previous pages ...

https://studentshare.org/biology/1685209-writers-choice

Catabolite repression and virulence gene expression in Listeria monocytogenes. / Gilbreth, Stefanie Evans; Benson, Andrew K.; ... Catabolite repression and virulence gene expression in Listeria monocytogenes. Stefanie Evans Gilbreth, Andrew K. Benson, ... Gilbreth, S. E., Benson, A. K., & Hutkins, R. W. (2004). Catabolite repression and virulence gene expression in Listeria ... Catabolite repression and virulence gene expression in Listeria monocytogenes. Current Microbiology. 2004 Aug;49(2):95-98. ...

https://experts.nebraska.edu/en/publications/catabolite-repression-and-virulence-gene-expression-in-listeria-m

We report the initial characterization of the carbon catabolite repression system in this organism. We find that sugar ... Jankovic I, Bruckner R: Carbon catabolite repression by the catabolite control protein CcpA in Staphylococcus xylosus . J Mol ... Carbon catabolite repression in Bacillus subtilis: quantitative analysis of repression exerted by different carbon sources. J ... Gorke B, Stulke J: Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol ...

https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/1754-6834-5-85

Catabolite repression was extensively studied in Escherichia coli . (wikipedia.org)
Until recently, only one mechanism of catabolite repression in bacteria, a mechanism dependent on the cyclic AMP receptor protein of Escherichia coli, was understood in molecular detail. (nih.gov)
The genome of the soil bacterium Pseudomonas putida KT2440 encodes singular orthologues of genes crp (encoding the catabolite repression protein, Crp) and cyaA (adenylate cyclase) of Escherichia coli. (nih.gov)
In Escherichia coli , the synthesis of the flagellar organelle is sensitive to catabolite repression. (asm.org)
1. The specific role of the lac repressor (i-gene product) in transient catabolite repression evoked by the introduction of glucose into the medium has been investigated in Escherichia coli by using mutants of the i-gene. (biochemj.org)
Relaxation of catabolite repression in streptomycin-dependent Escherichia coli. (thefreedictionary.com)
A quantitative approach to catabolite repression in Escherichia coli . (springer.com)

The transcriptome appeared to be regulated by carbon catabolite repression. (pnas.org)

Catabolite repression is considered to be a part of global control system and therefore it affects more genes rather than just lactose gene transcription. (wikipedia.org)
We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst transcription may be regulated by the catabolite control protein CcpA. (uzh.ch)
By introducing tst-genes under their native promoter or tst-promoter-reporter gene fusions in wild type strain Newman, we showed that glucose was able to repress tst transcription and TSST-1 production, whereas glucose repression was abolished in the corresponding DeltaccpA mutant. (uzh.ch)
Many microbial genes are subject to carbon catabolite repression (CCR), the repression in the presence of a preferred carbon source (e.g. glucose, sucrose) of the genes required for growth in the presence of less favourable carbon sources (e.g. acetamide, proline, quinate). (aspergillus.org.uk)
The different sugars produce signals which modify the conformation of certain proteins that, in turn, directly or through a regulatory cascade affect the expression of the genes subject to catabolite repression. (jbsdonline.com)
These genes are not all controlled by a single set of regulatory proteins (3, 4), but there are different circuits of repression for different groups of genes (2). (jbsdonline.com)
Since the expression of major catabolite repression-related genes did not show significant differences between MCD4 and AK46, these results showed that the higher maltose fermentative ability of MCD4 is due to the activation of MAL genes encoding two maltose permeases and two α-glucosidases. (mdpi.com)
Abstract Expression of pectinolytic genes is regulated by catabolic repression limiting the production of pectin lyase (PL) if the natural inducer, pectin , is missing from the growth medium. (bvsalud.org)
In our previous study, QU25 exhibited apparent CCR in a glucose-xylose mixture phenotypically, and transcriptional repression of the xylose operon encoding initial xylose metabolism genes, likely occurred in a CcpA-dependent manner. (elsevier.com)
Hence, the metabolism of xylose in the presence of cellobiose by QU25 may have been due to 1) sufficient amounts of proteins encoded by the xylose operon genes for xylose metabolism despite of the slight repression of the operon, and 2) bypassing of the pentose-phosphate pathway without the TalC activity. (elsevier.com)
The inhibition of gliding development in the presence of glucose was due, at least in part, to the repression of the genes pilT and pilD, whose products are essential for TFP-dependent gliding proficiency. (okstate.edu)
The presence of preferred carbon sources often prevents the utilization of secondary substrates by the regulatory mechanisms, including transcription activation or repression of certain genes concerned with the use of alternative carbon sources, which is called carbon catabolite repression (CCR) [ 11 , 12 ]. (biomedcentral.com)
On the other hand, Cra generally regulates carbon flux through by repression of genes encoding glycolytic pathway enzymes, or by activating key genes involved in the Krebs cycle, glyoxylate shunt, gluconeogenic pathways and electron transfer [ 16 ]. (biomedcentral.com)
When the cell is exposed to carbohydrate mixtures, the PTS prevents the expression of catabolic genes and activity of non-PTS sugars transport systems by carbon catabolite repression (CCR). (nih.gov)
cAMP, in turn, is required for the catabolite activator protein (CAP) to bind to DNA and activate the transcription of the lac operon, which includes genes necessary for lactose metabolism. (wikipedia.org)
Mig1 is a Cys2-His2 zinc finger protein that mediates glucose repression of several genes by binding to their promoters and recruiting the general repression complex Ssn6-Tup1. (semanticscholar.org)
Genes subject to glucose repression were mainly involved in the metabolism of alternative carbon sources including the control of glycerol uptake and metabolism. (biomedcentral.com)
Peroxisomal and methanol utilization genes were confirmed to be subject to carbon substrate repression in excess glucose or glycerol, but were found to be strongly de-repressed in limiting glucose-conditions (as are often applied in fed batch cultivations) in addition to induction by methanol. (biomedcentral.com)
In contrast, mutants impaired in the glucose-mediated repression of genes were 2DG resistant because glucose availability transcriptionally repressed DOG2 by inhibiting signaling mediated by the AMPK ortholog Snf1. (sciencemag.org)

Gram positive bacteria such as Bacillus subtilis have a cAMP -independent catabolite repression mechanism controlled by catabolite control protein A ( CcpA ). (wikipedia.org)
The second such mechanism, found in Bacillus subtilis, involves a catabolite-activated, ATP-dependent protein kinase that phosphorylates a specific seryl residue in the small phosphocarrier protein, HPr, of the phosphotransferase system. (nih.gov)
One form of catabolite repression (CR) in the Gram-positive genus, Bacillus, is mediated by a cis-acting element (CRE). (nih.gov)
The overcoming of catabolite repression, in bioinsecticides production by sporeless Bacillus thuringiensisstrain S22 was investigated into fully controlled 3 L fermenter, using glucose based medium. (edu.qa)
Saoussen Ben Khedher, Samir Jaoua, and Nabil Zouari, "Overcome of Carbon Catabolite Repression of Bioinsecticides Production by Sporeless Bacillus thuringiensis through Adequate Fermentation Technology," Biotechnology Research International, vol. 2014, Article ID 698587, 8 pages, 2014. (edu.qa)
Insertional mutagenesis was conducted on Bacillus subtilis cells to screen for mutants resistant to catabolite repression. (elsevierpure.com)
Catabolite repression in Bacillus subtilis: a global regulatory mechanism for the gram-positive bacteria? (psu.edu)
Rapoport G: Two different mechanisms mediate catabolite repression of the Bacillus subtilis levanase operon - Martin-Verstraete, Stülke, et al. (psu.edu)

When glucose is available in the environment, the synthesis of β-galactosidase is under repression due to the effect of catabolite repression caused by glucose. (wikipedia.org)
Measurements of intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentrations in E. coli under a variety of conditions show that levels of this nucleotide are well correlated with the rate of synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) in both catabolite repression and transient repression. (pnas.org)
These results, combined with extensive genetic and in vitro studies from a number of laboratories on the role of cAMP in E. coli, provide strong support for the concept that intracellular cAMP levels mediate the effects of catabolite and transient repression on rates on enzyme synthesis. (pnas.org)
An attempt has been made to find out how U.V. irradiation of E.coli B/r cells causes catabolite repression to inhibit L-arabinose isomerase synthesis. (osti.gov)
misc{etde_6096134, title = {Mechanism of ultraviolet light induced catabolite repression of L-arabinose isomerase} author = {Bhatnagar, D, and Bhattacharya, A K} abstractNote = {An attempt has been made to find out how U.V. irradiation of E.coli B/r cells causes catabolite repression to inhibit L-arabinose isomerase synthesis. (osti.gov)
The presence of the mutation resulted in flagella synthesis in Cya and Crp strains as well as in the wild type grown under conditions of catabolite repression. (asm.org)
Their synthesis was depressed in strains grown under conditions of catabolite repression. (asm.org)
We suggest that the formation of the flaI gene product is the step in flagellar synthesis that is catabolite sensitive and requires cAMP. (asm.org)
In this diploid the synthesis of thiogalactoside transacetylase suffered transient repression but the synthesis of β-galactosidase did not. (portlandpress.com)
Although the PTS-mediated regulation of cyclic AMP synthesis (catabolite repression) is not as well defined from a mechanistic standpoint, a model involving allosteric activation of adenylate cyclase by phospho-IIIGlc, together with the evidence supporting it, is presented. (asm.org)
Download file to see previous pages Apart from induction, synthesis rate is determined by catabolite repression, whereby it slows down the synthesis of beta-galactosidase especially in the presence of a better carbon (and energy) source, such as glucose. (studentshare.org)
Apart from induction, synthesis of β-galactosidase is also influenced by catabolite repression. (studentshare.org)
Catabolite Repression and Induction of Beta-Galactosidase Synthesis Lab Report", n.d. https://studentshare.org/biology/1685209-writers-choice. (studentshare.org)
In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. (microbiologyresearch.org)
This was indicated by acetate synthesis pathways PTA-ACKA and POXB component expression down-regulation before the overflow switch at μ = 0.27 ± 0.02 h -1 with concurrent 5-fold stronger repression of acetate-consuming Acs. (biomedcentral.com)
Effect of specific growth rate on acetate synthesis and utilization pathways, selected TCA cycle and carbon catabolite repressed gene and protein expression levels in E. coli A-stat experiments . (biomedcentral.com)
Biotrophy may also depend on additional controls, such as catabolite repression of CWDE synthesis resulting from the characteristic influx of photosynthates to infected areas (Cooper, 1983). (thefreedictionary.com)

Note that E. coli has a similar cAMP-independent catabolite repression mechanism that utilizes a protein called catabolite repressor activator (Cra). (wikipedia.org)
One such mechanism, found in E. coli, involves the catabolite repressor/activator (Cra) protein (formerly designated the fructose repressor FruR) which represses sugar catabolic systems and activates sugar anabolic systems. (nih.gov)
The gene encoding catabolite repressor/activator (Cra) was deleted in the genome of E. aerogenes to increase the fructose consumption rate. (biomedcentral.com)
In enteric bacteria, two dominant CCR mechanisms involve transcriptional regulation by cyclic AMP receptor protein (Crp) and by catabolite repressor/activator (Cra) [ 13 ]. (biomedcentral.com)

Catabolite repression was thoroughly studied in the bacterium Escherihia coli and, though not so well, in the yeast Saccharomyces cerevisiae (1, 2). (jbsdonline.com)
The aim of this work was to develop constitutive catabolite repression mutants in a xylose-utilising recombinant Saccharomyces cerevisiae strain and evaluate the differences in xylose consumption under fermentation conditions. (sun.ac.za)

6. These and previously reported results can be explained by assuming ( a ) that both mutations L8 and L29 render the lac promoter partially, but not completely, insensitive to catabolite repression, and ( b ) that transient repression is an exceptionally severe form of catabolite repression. (portlandpress.com)

It is therefore concluded that the mechanism of catabolite repression induced by U.V. appears to be different from that of the catabolite repression by glucose. (osti.gov)

The phenomenon of catabolite repression in Yarrowia lipolytica yeast is poorly studied. (jbsdonline.com)
We conclude that B. subtilis possesses at least two distinct routes of glucose entry, both of which contribute to the phenomenon of catabolite repression. (elsevierpure.com)

Carbon catabolite repression , or simply catabolite repression , is an important part of global control system of various bacteria and other micro-organisms. (wikipedia.org)
The characterization of these novel mechanisms establishes that cyclic AMP-independent catabolite control is operative in bacteria, and that multiple mechanisms of catabolite control evolved independently of each other. (nih.gov)
Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria. (nih.gov)
Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. (microbiologyresearch.org)
Generally, Firmicutes bacteria show preferential consumption of sugar (usually glucose), termed carbon catabolite repression (CCR), while hampering the catabolism of other sugars. (elsevier.com)
A novel protein kinase that controls carbon catabolite repression in bacteria. (ebi.ac.uk)
Catabolite repression and inducer control in Gram-positive bacteria. (psu.edu)

All known nitrogen catabolite pathways are regulated by four regulators. (springer.com)
The ultimate goal is to infer the complete nitrogen catabolite pathways. (springer.com)
Crc (catabolite repression control) protein of Pseudomonas aeruginosa has shown to be involved in carbon regulation of several pathways. (ecu.edu)
The presence of protocatechuate caused transcriptional repression of the vanA , B - and hca -encoded funnelling pathways (vertical regulation). (microbiologyresearch.org)
However, the sugar mixture in sugarcane molasses is not consumed as efficiently as glucose in microbial fermentation due to complex interactions among their utilizing pathways, such as carbon catabolite repression (CCR). (biomedcentral.com)
Glucose exerts its dramatic effects upon S. cerevisiae physiology via signaling pathways that include the glucose repression (Snf1 AMP kinase) pathway, cyclic AMP (cAMP)-protein kinase A signaling, and the sugar receptor repressor (Snf3-Rgt2) pathway (for reviews, see references 7 to 12 ). (asm.org)
Moreover, in the case of yeast, D-xylose may provide a better feedstock for the production of bioproducts other than ethanol, because the relevant pathways are not subject to glucose-dependent repression. (springer.com)

Regulatory exaptation of the catabolite repression protein (Crp)-cAMP system in Pseudomonas putida. (nih.gov)
Garcia, Preston Philip, "Control of succinate-mediated catabolite repression through a two-component regulatory system in Sinorhizobium meliloti" (2008). (uconn.edu)
Our results demonstrate that carbon catabolite regulation constitutes an important physiological regulatory mechanism that reduces the proficiencies of the gliding motilities of a large number of unrelated human- and animal-derived pathogenic C. perfringens strains. (okstate.edu)
The inhibitory effects of glucose on pilT and pilD expression were under the control of the key regulatory protein CcpA (catabolite control protein A). The deficiency in CcpA activity of a ccpA knockout C. perfringens mutant strain restored the expressions of pilT and pilD and gliding proficiency in the presence of 1% glucose. (okstate.edu)
IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. (thefreedictionary.com)
Hfq of the opportunistic pathogen inhibits translation of target transcripts by forming a regulatory complex with the catabolite repression protein Crc. (pdbj.org)
RT "CreA mediates repression of the regulatory gene xlnR which controls RT the production of xylanolytic enzymes in Aspergillus nidulans. (genome.jp)

Full expression of lacTEGF was found only in a man ccpA double mutant, indicating that PTS elements are involved in the CcpA-independent catabolite repression mechanism probably via LacT. (asm.org)
The catabolite control protein CcpA binds to P mga and influences expression of the virulence regulator Mga in the Group A streptococcus. (microbiologyresearch.org)
The carbon catabolite repression of the gliding motility of the ccpA mutant strain was restored after the introduction of a complementing plasmid harboring a wild-type copy of ccpA. (okstate.edu)
These results point to a central role for CcpA in orchestrating the negative effect of carbon catabolite regulation on C. perfringens gliding motility. (okstate.edu)
Furthermore, we discovered a novel positive role for CcpA in pilT and pilD expression and gliding proficiency in the absence of catabolite regulation. (okstate.edu)
Carbon catabolite repression of gliding motility and the dual role of CcpA, either as repressor or as activator of gliding, are analyzed in the context of the different social behaviors and diseases produced by C. perfringens. (okstate.edu)

1. Experiments were devised to show whether the point mutations L8 and L29 in the lac promoter alleviate transient repression. (portlandpress.com)
All of the 19 p − recombinants tested proved to suffer no transient repression, whereas all of the eight p + recombinants tested suffered prolonged transient repression. (portlandpress.com)
4. Insertion of Flaci + into this strain restores both inducibility and transient repression. (biochemj.org)

The two amino acid substitutions in XylR enhance xylose utilization and release glucose-induced repression in different E. coli hosts, including wild type, suggesting its potential wide application in industrial E. coli biocatalysts. (elsevier.com)
Inhibition de l'adaptation Enzymatique chez B. Coli en Présence de 2-4 Dinitrophénol. (elsevier.com)
The dual-layered catabolite repression was identified and successfully removed in the engineered E. coli , and the compound ( R )-3-hydroxybutyric acid was produced from simultaneous assimilation of glucose, xylose and arabinose. (diva-portal.org)

Catabolite repression (of the respiratory system) is seen in yeast in high glucose concentrations, though the mechanism is different. (enacademic.com)
Yeast carbon catabolite repression. (semanticscholar.org)

Identified XylR variants (R121C and P363S) have a higher affinity to their DNA binding sites, leading to a xylose catabolic activation independent of catabolite repression control. (elsevier.com)

cAMP binds to catabolite activator protein (CAP) and together they will bind to a promoter sequence on the lac operon . (wikipedia.org)
DNA binding of the complex in turn promotes catabolite repression or catabolite activation, depending on the target operon. (nih.gov)
It has previously been reported ( 22 , 34 ) that the expression of the lac operon in L. casei ATCC 393[pLZ15 − ] is subject to dual regulation: carbon catabolite repression (CR) and induction by lactose through transcriptional antitermination. (asm.org)

Since carbon catabolite regulation has been implicated in the control of different bacterial behaviors, we investigated the effects of glucose and other readily metabolized carbohydrates on C. perfringens gliding motility. (okstate.edu)
Enzyme production regulation is influenced by catabolite repression. (thefreedictionary.com)
We do not imply that catabolite regulation is the sole basis for this effect, but rather that catabolite regulation may be indirect, since the major evolutionary benefit derived from catabolite repressive mechanism may have resulted in enhancing the endophyte's ability to efficiently scavenge nutrients from such a nutrient poor location, thereby avoiding the usual cellular invasive, destructive mode for obtaining nutrient used by most biotrophic pathogenic fungi. (thefreedictionary.com)
The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. (genecards.org)
Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. (genecards.org)
Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression . (wikipedia.org)

To determine whether virulence gene expression was also influenced by catabolite repression, we performed primer extension experiments, using primers for hly and prfA, which encode for a hemolysin and the regulator protein PrfA, respectively. (nebraska.edu)
SIP1 is a Catabolite Repression-Specific Negative Regulator of GAL Gen" by Larry M. Mylin, V. L. Bushman et al. (messiah.edu)
These studies show that SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. (messiah.edu)

The catabolite repression in this case is achieved through the utilization of phosphotransferase system . (wikipedia.org)
Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system. (asm.org)

Carbon catabolite repression (CCR) is a strategy to ensure optimal carbon metabolism. (unl.edu)
We believe that this two component system may use sensory information about redox levels or energy state gathered from the PAS domains of Sma0113 to modulate electron flow and metabolism by catabolite repression. (uconn.edu)
Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. (illumina.com)

One of the best characterized of these is the process by which the PTS regulates inducer uptake and catabolite repression. (asm.org)
Crc regulates the expression of branched-chain keto acid dehydrogenase, glucose-6-phosphate dehydrogenase, and amidase in both species but not urocanase, although the carbon sources responsible for catabolite repression in the two species differ. (ecu.edu)
These findings suggest a model in which the Snf1 kinase positively regulates Flo11-dependent developmental events by antagonizing Nrg-mediated repression of the FLO11 gene. (asm.org)

The endo-acting [beta]-glucanase secretion is controlled by glucose-mediated catabolite repression and induced mainly by media containing cell-wall materials. (thefreedictionary.com)

The first step in acetate overflow switch (at μ = 0.27 ± 0.02 h -1 ) is the repression of acetyl-CoA synthethase (Acs) activity triggered by carbon catabolite repression resulting in decreased assimilation of acetate produced by phosphotransacetylase (Pta), and disruption of the PTA-ACS node. (biomedcentral.com)
As Schizochytrium is a slow growing heterotroph consuming glucose at a slow rate, wai cultivation in a non carbon catabolite repression condition or in an increased acetyl-CoA synthethase state gives rise to higher growth and glucose consumption rates (27). (thefreedictionary.com)

Multiple operons feeding into the β -ketoadipate pathway are controlled by carbon catabolite repression (CCR) caused by succinate plus acetate. (microbiologyresearch.org)
Thickness of red arrows denotes level of ACS and PTA-ACKA pathway repression (thick line represents stronger repression). (biomedcentral.com)

The bkd operons of P. putida and P. aeruginosa encode the inducible multienzyme complex branched-chain keto acid dehydrogenase, which is regulated in both species by catabolite repression. (ecu.edu)
The Crc ( c atabolite r epression c ontrol) protein is involved in repression of all operons (except for catA ), as demonstrated by the analysis of respective crc strains. (microbiologyresearch.org)

Dal80-dependent repression of NCR-sensitive gene expression occurred at three possible levels: Dal80 represses GAT1 expression, it competes with Gat1 for binding, and it directly represses NCR gene transcription. (asm.org)

However, the term "glucose effect" is actually a misnomer since other carbon sources are known to induce catabolite repression. (wikipedia.org)
The phenomenon of using succinate as the sole carbon source in the presence of secondary carbon sources is termed Succinate Mediated Catabolite Repression (SMCR). (uconn.edu)

A low-molecular-weight (about 34 kDa) protein was identified and shown to interact with a region of the CIT1gene promoter (from -367 to -348 bp), which controls the glucose repression. (deepdyve.com)

We have isolated the SIP1 gene as a multicopy suppressor of the gal83-associated defect in glucose repression of GAL gene expression. (messiah.edu)

We report the initial characterization of the carbon catabolite repression system in this organism. (biomedcentral.com)

The creC carbon catabolite repression gene of Aspergillus nidulans encodes a protein containing WD40 repeats. (aspergillus.org.uk)
Nuclear export-dependent degradation of the carbon catabolite repressor CreA is regulated by a region located near the C-terminus in Aspergillus oryzae. (semanticscholar.org)
RT "Carbon catabolite repression of the Aspergillus nidulans xlnA gene. (genome.jp)

In this study, the role of Crc in catabolite repression control has been studied in Pseudomonas putida. (ecu.edu)

Constitutive catabolite repressed strain YCR17 grew four-fold better on xylose in aerobic conditions than the control strain YUSM. (sun.ac.za)
This study shows that a constitutive catabolite repressed mutant could be used to enhance the xylose consumption rate even in the presence of high glucose in the fermentation medium. (sun.ac.za)
Three of these strains were catabolite repression mutants (ptsG**-) that have the ability to simultaneously ferment glucose and xylose. (usda.gov)

However, when expressed in C. albicans , S. cerevisiae Icl1 (ScIcl1) is subjected to glucose-accelerated degradation, indicating that like S. cerevisiae , this pathogen has the molecular apparatus required to execute ubiquitin-dependent catabolite inactivation. (asm.org)

These mutants suggested that catabolite repression in pseudomonads might, in part, involve control of BkdR levels. (ecu.edu)

Catabolite repression allows microorganisms to adapt quickly to a preferred (rapidly metabolizable) carbon and energy source first. (wikipedia.org)
Catabolite repression allows the respective microorganisms effectively use carbohydrate substrates, which first assimilate one of the two available substrates (commonly, a carbohydrate), whereas the assimilation of the other substrate starts only after the first substrate is fully consumed from the medium. (jbsdonline.com)
The degree of catabolite repression varies very significantly in microorganisms. (jbsdonline.com)

5. The same diploid strains were used in experiments to show whether mutations L8 and L29 alleviate the severe catabolite repression caused by growth in glucose plus gluconate. (portlandpress.com)

Only when glucose was consumed were these sugars fermented, indicating that catabolite repression by glucose had occurred. (nebraska.edu)
The order in which sugars are utilized is frequently determined by a mechanism known as carbon catabolite repression (CCR) [ 1 ]. (biomedcentral.com)

At 42° it is about 20% constitutive and transient catabolite repression is abolished. (biochemj.org)
3. A strain carrying an amber suppressor-sensitive mutation in the i-gene is phenotypically constitutive and also fails to show transient catabolite repression. (biochemj.org)

Tn10 mutation (i) partially but specifically relieved glucose- and sucrose-promoted catabolite repression, (ii) reduced the growth rate in minimal glucose medium, and (iii) reduced rates of [ 14 C]glucose and [ 14 C]methyl α-glucoside uptake. (elsevierpure.com)
It may be the only lactate uptake porter and is subject to glucose catabolite repression. (tcdb.org)

When catabolites bind to Cra, Cra dissociates from the DNA causing catabolite activation and catabolite repression, respectively. (nih.gov)

Anatomy5

Organisms23

Diseases1

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes67

Disciplines and Occupations2

Information Science3

Health Care1

Transcriptional analysis of differential carbohydrate utilization by Clostridium acetobutylicum. (1/31)

Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy. (2/31)

Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass. (3/31)

Escherichia coli mhpR gene expression is regulated by catabolite repression mediated by the cAMP-CRP complex. (4/31)

Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. (5/31)

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria. (6/31)

cAMP receptor protein (CRP) positively regulates the yihU-yshA operon in Salmonella enterica serovar Typhi. (7/31)

Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus. (8/31)

Catabolite Repression

Enzyme Repression

Galactosidases

Repressor Proteins

Phosphoenolpyruvate Sugar Phosphotransferase System

Gene Expression Regulation, Bacterial

Operon

Gluconates

Glucose

Carbon

Bacterial Proteins

Bacillus subtilis

Cyclic AMP Receptor Protein

Mutation

Succinates

Escherichia coli

Tryptophanase

Histidine Ammonia-Lyase

Transcription, Genetic

Molecular Sequence Data

Allantoin

Base Sequence

Enzyme Induction

Lactose

Xylose

Promoter Regions, Genetic

Arabinose

beta-Galactosidase

Gene Expression Regulation, Fungal

Glycerol

Genes, Regulator

DNA-Binding Proteins

Transcription Factors

Genes, Bacterial

Nitrogen

Urocanate Hydratase

Culture Media

Lac Operon

Saccharomyces cerevisiae

Lyases

Glycoside Hydrolases

Pseudomonas putida

Cyclic AMP

Galactose

Receptors, Cyclic AMP

Ammonia-Lyases

Carbohydrate Metabolism

Succinic Acid

GATA Transcription Factors

Plasmids

Genetics, Microbial

Maltose

Carbohydrate Epimerases

Genes, Fungal

Cellobiose

beta-Fructofuranosidase

Amino Acid Sequence

Fungal Proteins

Hexokinase

alpha-Amylases

Molecular Biology

Cloning, Molecular

Aspergillus nidulans

Acetoin Dehydrogenase

Arbutin

Fructose

DNA, Bacterial

Escherichia coli Proteins

Glucokinase

RNA, Bacterial

Regulon

Lactobacillus casei

Gene Expression Regulation

Acetate-CoA Ligase

Aldose-Ketose Isomerases

Galactokinase

Operator Regions, Genetic

Recombinant Fusion Proteins

Genes

Gene Deletion