Catabolite Repression
Enzyme Repression
Galactosidases
Repressor Proteins
Phosphoenolpyruvate Sugar Phosphotransferase System
The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
Gene Expression Regulation, Bacterial
Operon
Glucose
Carbon
Cyclic AMP Receptor Protein
A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.
Mutation
Succinates
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Tryptophanase
An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.
Histidine Ammonia-Lyase
Transcription, Genetic
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Allantoin
Base Sequence
Enzyme Induction
Lactose
Promoter Regions, Genetic
beta-Galactosidase
Gene Expression Regulation, Fungal
Glycerol
Genes, Regulator
DNA-Binding Proteins
Transcription Factors
Nitrogen
Urocanate Hydratase
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Lac Operon
Saccharomyces cerevisiae
Lyases
Pseudomonas putida
Cyclic AMP
Galactose
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Receptors, Cyclic AMP
Cell surface proteins that bind cyclic AMP with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized cyclic AMP receptors are those of the slime mold Dictyostelium discoideum. The transcription regulator CYCLIC AMP RECEPTOR PROTEIN of prokaryotes is not included nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.
Ammonia-Lyases
Carbohydrate Metabolism
Succinic Acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
GATA Transcription Factors
Plasmids
Genetics, Microbial
Maltose
Carbohydrate Epimerases
Cellobiose
beta-Fructofuranosidase
Amino Acid Sequence
Hexokinase
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
alpha-Amylases
Molecular Biology
Cloning, Molecular
Aspergillus nidulans
Acetoin Dehydrogenase
Fructose
Glucokinase
RNA, Bacterial
Regulon
Lactobacillus casei
Gene Expression Regulation
Acetate-CoA Ligase
Galactokinase
Operator Regions, Genetic
Recombinant Fusion Proteins
Genes
Gene Deletion
Binding Sites
Protein Binding
Gene Expression Regulation, Enzymologic
Saccharomyces cerevisiae Proteins
Artificial Gene Fusion
Protocatechuate-3,4-Dioxygenase
Carbon Isotopes
Leucine-Responsive Regulatory Protein
Anaerobiosis
alpha-Glucosidases
Genes, Reporter
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Suppression, Genetic
Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).
Aconitate Hydratase
Phosphotransferases (Nitrogenous Group Acceptor)
Xylosidases
A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 catalyzes the endo-hydrolysis of 1,4-beta-D-xylosidic linkages; EC 3.2.1.32 catalyzes the endo-hydrolysis of 1,3-beta-D-xylosidic linkages; EC 3.2.1.37 catalyzes the exo-hydrolysis of 1,4-beta-D-linkages from the non-reducing termini of xylans; and EC 3.2.1.72 catalyzes the exo-hydrolysis of 1,3-beta-D-linkages from the non-reducing termini of xylans. Other xylosidases have been identified that catalyze the hydrolysis of alpha-xylosidic bonds.
Glycerol Kinase
An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 2.7.1.30.
Regulatory Sequences, Nucleic Acid
Acetoin
Styrene
Acetates
Benzyl Alcohols
Genetic Complementation Test
Mutagenesis, Insertional
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Cell-Free System
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)
Chromosome Mapping
Phosphotransferases
Bacillus megaterium
Fermentation
Lac Repressors
Transduction, Genetic
Fructose-Bisphosphatase
Biodegradation, Environmental
Sugar Alcohol Dehydrogenases
Mutagenesis
Pseudomonas aeruginosa
Restriction Mapping
Thiogalactosides
Membrane Transport Proteins
Alcohol Oxidoreductases
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Endo-1,4-beta Xylanases
DNA Footprinting
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Trans-Activators
Hydro-Lyases
Proline
Sequence Homology, Amino Acid
Pectins
High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.
Transcriptional Activation
Agmatine
DNA Primers
Down-Regulation
Citric Acid Cycle
Electrophoretic Mobility Shift Assay
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
Zinc Fingers
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Glutamate-Ammonia Ligase
Cellulase
Biological Transport
Pseudomonas
Ketoglutaric Acids
Isomerases
Alkanes
Nuclear Proteins
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Blotting, Northern
Glutamates
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Streptococcus gordonii
Salmonella typhimurium
Pectobacterium chrysanthemi
Sorbitol
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
Carrier Proteins
Sequence Analysis, DNA
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Acetic Acid
Protein Biosynthesis
Models, Genetic
Models, Biological
Hydrolases
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
Sinorhizobium meliloti
Asparaginase
Phosphorylation
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Consensus Sequence
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Spores, Bacterial
Monosaccharide Transport Proteins
Transformation, Genetic
Streptococcus mutans
Gene Silencing
Phenotype
Epigenetic Repression
Mannitol
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Chromosomes, Bacterial
Carboxylic Acids
Mutagenesis, Site-Directed
Glycolysis
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
Gene Expression Profiling
Adenylate Cyclase
Extrachromosomal Inheritance
Integration Host Factors
Transcriptional analysis of differential carbohydrate utilization by Clostridium acetobutylicum. (1/31)
(+info)Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy. (2/31)
(+info)Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass. (3/31)
(+info)Escherichia coli mhpR gene expression is regulated by catabolite repression mediated by the cAMP-CRP complex. (4/31)
(+info)Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. (5/31)
(+info)Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria. (6/31)
(+info)cAMP receptor protein (CRP) positively regulates the yihU-yshA operon in Salmonella enterica serovar Typhi. (7/31)
(+info)Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus. (8/31)
(+info)
Go with your gut | PEP Inc.
Author: Wu, Yingmei / Publication Year: 2019 - PubAg Search Results
Soybean soluble polysaccharides enhance bioavailability of genistein and its prevention against obesity and metabolic syndrome...
Paul W. Hager , NC DOCKS (North Carolina Digital Online Collection of Knowledge and Scholarship)
URC Participates in 44th World Conference on Lung Health | URC
Partnership for HIV-Free Survival project report on Tanzania-Kenya knowledge exchange published | URC
Vinyasa power joga
Simultaneous consumption of cellobiose and xylose by Bacillus coagulans to circumvent glucose repression and identification of...
Carbon catabolite repression of type IV pilus-dependent gliding motility in the anaerobic pathogen Clostridium perfringens<...
ISC West 2017: Few CEDIA Smart-Home Brands Chasing Security Dealers - CE Pro
You Are Here
PEPFAR Country/Regional Operational Plans (COPs/ROPs) Database, amfAR, The Foundation for AIDS Research
URC launches resource to help renew community engagement as we emerge from the pandemic
Biotin-11-dUTP, 50 µl, 50 nmol | dNTPs | Nucleotides for PCR | PCR (Polymerase chain reaction) | Applications | Carl Roth -...
[email protected]: Role of catabolite repression in sporulation of Bacillus subtilis
University Records Center choose Fujitsu Cloud - Fujitsu France
Catabolite repression - Wikipedia
EM in Cambodia - Ushas whirlwind of traveling and planning | Global Emergency Medicine
subject:(Iron Metabolism Genetic aspects) - OATD
pkgsrc 20009Q1 NetBSD 4.0/powerpc bulk build results 20090511.1545
The Macmillan Nurses Coffee Morning | The Comet
1YWU | Genus
NATROL VITAMINS BIOTIN-1000mcg, 5K mcg, 10K mcg, FAST DISSOLVE, MORE… - MedLancr
Co2crea Case | Travelcase
Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose...
The effect of CreA in glucose and xylose catabolism in Aspergillus nidulans - DTU Orbit
The Saccharomyces cerevisiae RTG2 Gene Is a Regulator of Aconitase Expression Under Catabolite Repression Conditions | Genetics
URC Learning » Topics
oliviamaria(nicolae)marcov: bucharest, romania: Tr : salut ! bonjour à tous, / le 6 août 2016 fête de la Transfiguration du...
Transcriptional Regulation Contributes to Prioritized Detoxification of Hydrogen Peroxide over Nitric Oxide. | Department of...
looking for gene clone review
Biotin-21-dUTP
URC WEB: Urine Pretreatment
Most recent papers with the keyword Ophthamology | Read by QxMD
Reconstruction of xylose utilization pathway and regulons in Firmicutes | Springer for Research & Development
MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION - Energy Innovation Portal
NAVER Academic | Penicillinamidohydrolase inEscherichia coli
Daily Ohio State journal (Columbus, Ohio : 1870), 1872-02-14, MORNING EDITION :: The Ohio State Journal
What is Positive Regulation of Lac Operon?
OPUS Würzburg | Search
URC tops nation for advanced degrees in medicine and biological science | MSUToday | Michigan State University
URC Daily Devotions Sunday Worship for 6th June 2021 - Kirsty-Ann Mabbott - St Andrews Church
Structure Cluster
- 1MO1: CRYSTAL STRUCTURE AT 1.8 ANGSTROMS OF SELENO METHIONYLED CRH, THE BACILLUS SUBTILIS...
Lyrads Random 10
Exogenous anthrahydroquinone-2,6-disulfonate specifically increases xylose utilization during mixed sugar fermentation by...
Cyclic AMP-Dependent Catabolite Repression Is the Dominant Control Mechanism of Metabolic Fluxes under Glucose Limitation in...
Technical Consultation
Sermon: Heart Rooted Tongues | Jason Helopoulos | URC
Amide Utilization in Aspergillus nidulans: Evidence for a Third Amidase Enzyme | Microbiology Society
Speakers - Licensing Executives Society (LES)
Delray Cerebral Palsy Victim Finds His Calling - tribunedigital-sunsentinel
Diauxie
CS1 maint: discouraged parameter (link) Stülke J, Hillen W. (1999). "Carbon catabolite repression in bacteria". Current Opinion ... is required for the catabolite activator protein (CAP) to bind to DNA and activate the transcription of the lac operon, which ...
Lac operon
Two puzzles of catabolite repression relate to how cAMP levels are coupled to the presence of glucose, and secondly, why the ... Catabolite repression Griffiths, Anthony J.F.; Wessler, Susan R.; Carroll, Sean B.; Doebley, John (2015). An Introduction to ... Görke B, Stülke J (August 2008). "Carbon catabolite repression in bacteria: many ways to make the most out of nutrients". ... Binding of RNA polymerase to the promoter is aided by the cAMP-bound catabolite activator protein (CAP, also known as the cAMP ...
Fed-batch culture
4. Catabolite repression[1] When a microorganism is provided with a rapidly metabolizable carbon-energy source such as glucose ... A powerful method of overcoming the catabolite repression in the enzyme biosynthesis is a fed-batch culture in which glucose ... This phenomenon is known as catabolite repression. Many enzymes, especially those involved in catabolic pathways, are subject ... Substrate limitation also allows the metabolic control, to avoid osmotic effects, catabolite repression and overflow metabolism ...
Streptomyces albaduncus
Harchand, R. K.; Singh, S (1994). "Catabolite repression of cellulase biosynthesis in Streptomyces albaduncus". Journal of ...
Ian A. Graham
Graham, I. A.; Denby, K. J.; Leaver, C. J. (1994). "Carbon Catabolite Repression Regulates Glyoxylate Cycle Gene Expression in ...
Mal regulon
malT is regulated by catabolite repression via the catabolite activator protein. Genes under the control of malT include ATP- ...
Thermotoga neapolitana
Vargas M; Noll KM (January 1996). "Catabolite repression in the hyperthermophilic bacterium Thermotoga neapolitana is ...
CrcZ
... is a small RNA found in Pseudomonas bacteria, which acts as a global regulator of carbon catabolite repression. In P. ... Sonnleitner E, Abdou L, Haas D (December 2009). "Small RNA as global regulator of carbon catabolite repression in Pseudomonas ... Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression ... and catabolite repression is high. In the presence of poor sources of carbon, such as mannitol, CrcZ expression is high, ...
Super Optimal Broth
... with Catabolite repression (SOC) is SOB with added glucose. (Figures in parentheses are the masses required ...
Clostridium difficile toxin A
Environmental stresses such as antibiotics and catabolite repression can influence toxin expression. The tcdA and tcdB genes ...
Crc (protein)
The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization ... Zhang L, Chiang WC, Gao Q, Givskov M, Tolker-Nielsen T, Yang L, Zhang G (December 2012). "The catabolite repression control ... Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression ... "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6): e1004440. doi ...
LacUV5
Some of them, including UV5, has lost catabolite repression at the CAP site. Development into cloning vectors is known since ... Silverstone, AE; Arditti, RR; Magasanik, B (July 1970). "Catabolite-insensitive revertants of lac promoter mutants". ...
Glycolysis
Examining Escherichia coli glycolytic pathways, catabolite repression, and metabolite channeling using Δ pfk mutants. ...
Agnes Ullmann
Later, she discovered another factor that boosts catabolite repression (catabolite modulator factor, or CMF). Ullmann ... In 1967 she showed that cAMP reverses catabolite repression in the bacterium E. coli. ...
MTOR
Peter GJ, Düring L, Ahmed A (March 2006). "Carbon catabolite repression regulates amino acid permeases in Saccharomyces ... "Sustained translational repression by eIF2α-P mediates prion neurodegeneration". Nature. 485 (7399): 507-11. Bibcode:2012Natur. ... "PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR". Nature. 442 (7104): 779-85. Bibcode: ...
Penicillium decumbens
"Transcription analysis of lignocellulolytic enzymes of Penicillium decumbens 114-2 and its catabolite-repression-resistant ...
Butanol fuel
Nakashima, Nobutaka; Tamura, Tomohiro (1 July 2012). "A new carbon catabolite repression mutation of Escherichia coli, mlc∗, ...
Sucrose phosphorylase
Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression. First ...
Walter Dobrogosz
Lee JH, Dobrogosz WJ (May 1983). "Effects of aerobic and anaerobic shock on catabolite repression in cyclic AMP suppressor ... In particular, his research focused on the phenomenon of catabolite repression, a regulatory system involving interactions of ... cyclic AMP, the catabolite repressor protein (CRP) complex, and the lac operon and other inducible systems in bacteria. The ...
GalP (protein)
Galactose is an alternate carbon source to the preferable glucose . The cAMP/CRP catabolite repression regulator is most likely ... 5. El Qaidi, S., Allemand, J.O., and Plumbridge, J. (2009). Repression of galP, the galactose transporter in Escherichia coli, ... so both of these proteins are required for repression (11). cAMP is what modulates CRP at the promoter. The cAMP-CRP complex ... a protein from the nagC gene which is responsible for N-acetylglucosamine repression (5). This study suspects that NagC ...
CCR4-Not
Carbon Catabolite Repression-Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. ...
Morpheein
2004). "HPr kinase/phosphorylase, a Walker motif A-containing bifunctional sensor enzyme controlling catabolite repression in ...
SuhB
... which results in thn gene repression in catabolite repression conditions. EcpR1 sRNA RcsR1 small RNA Corbino KA, Barrick JE, ... catabolite repression conditions). This phenotype is due to the release of the negative effect of suhB on ThnR translation. Hfq ... a small non-coding RNA involved in catabolite repression of tetralin degradation genes in Sphingopyxis granuli strain TFA". ...
Karine A. Gibbs
She found that the catabolite repression control protein, which regulates carbon metabolism, is essential for biofilm formation ...
Spot 42 RNA
"The Base-Pairing RNA Spot 42 Participates in a Multioutput Feedforward Loop to Help Enact Catabolite Repression in Escherichia ... The direct responsiveness of Spot 42 levels to glucose and cAMP is due to repression of spf expression by a cAMP-CRP (cAMP- ...
P. N. Rangarajan
Vijay Kumar, N.; Rangarajan, P. N. (2011). "Catabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein ... Rabies vaccine Foot-and-mouth disease Plasmodium falciparum Catabolite repression India portal Medicine portal Long link - ...
Quorum sensing
This explains why, when grown with glucose, E. coli will lose the ability to internalize AI-2 (because of catabolite repression ...
Changestat
... biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression ...
Expression vector
... most commonly used lac or lac-derived promoters are based on the lacUV5 mutant which is insensitive to catabolite repression. ... PMID 6337371.CS1 maint: multiple names: authors list (link) Silverstone AE, Arditti RR, Magasanik B (1970). "Catabolite- ...
Selman A. Waksman Award in Microbiology
Boris Magasanik (1993) For his contributions to our understanding of catabolite repression, amino acid metabolism, and ...
Farnesoid X receptor
nitrogen catabolite activation of transcription from RNA polymerase II promoter. • negative regulation of tumor necrosis factor ... "Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids". ...
Catabolite repression
... β-galactosidase is under repression due to the effect of catabolite repression caused by glucose. The catabolite repression in ... Carbon catabolite repression, or simply catabolite repression, is an important part of global control system of various ... Note that E. coli has a similar cAMP-independent catabolite repression mechanism that utilizes a protein called catabolite ... Catabolite repression was extensively studied in Escherichia coli. E. coli grows faster on glucose than on any other carbon ...
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing
... super optimal broth with catabolite repression), colonies were patched onto selective plates using a toothpick and incubated at ...
Thermomyces lanuginosus
... because the invertase is insensitive to catabolite repression by glucose, and because the activity of the glucose uptake system ...
Arabinose
... presence of glucose or reversed off by the addition of glucose in the culture medium which is a form of catabolite repression. ...
CCR
... a variation of Cardiopulmonary Resuscitation Carbon catabolite repression, part of the adaptive metabolic control system ...
Botryosphaeran
Catabolite repression, and the presence of β-glucan-hydrolyzing enzymes that attack botryosphaeran during the fermentation ...
Dcu family
... while it is repressed by nitrate and subject to CRP-mediated catabolite repression. DcuC family Zientz E, Six S, Unden G ( ...
Escherichia coli
Catabolite repression has also been observed in E.coli in the presence of other non-glucose sugars, such as arabinose and ... In E. coli, glucose catabolite repression is regulated by the phosphotransferase system, a multi-protein phosphorylation ... bacteria will often consume the sugars sequentially through a process known as catabolite repression. By repressing the ...
CRC
... catabolite repression control protein Criminal record check Cross Racing Championship Extreme 2005 (CRC 2005), a car-racing ...
Catabolite repression - Wikipedia
... β-galactosidase is under repression due to the effect of catabolite repression caused by glucose. The catabolite repression in ... Carbon catabolite repression, or simply catabolite repression, is an important part of global control system of various ... Note that E. coli has a similar cAMP-independent catabolite repression mechanism that utilizes a protein called catabolite ... Catabolite repression was extensively studied in Escherichia coli. E. coli grows faster on glucose than on any other carbon ...
Cyclic AMP-independent catabolite repression in bacteria
Two cyclic AMP-independent catabolite repression mechanisms are currently under study. One such mechanism, found … ... only one mechanism of catabolite repression in bacteria, a mechanism dependent on the cyclic AMP receptor protein of ... When catabolites bind to Cra, Cra dissociates from the DNA causing catabolite activation and catabolite repression, ... DNA binding of the complex in turn promotes catabolite repression or catabolite activation, depending on the target operon. The ...
Adenosine 3':5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli | PNAS
... in both catabolite repression and transient repression. These results, combined with extensive genetic and in vitro studies ... Adenosine 3:5-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. W Epstein, L B Rothman-Denes, ... Adenosine 3:5-cyclic monophosphate as mediator of catabolite repression in Escherichia coli ... Adenosine 3:5-cyclic monophosphate as mediator of catabolite repression in Escherichia coli ...
Regulatory exaptation of the catabolite repression protein (Crp)-cAMP system in Pseudomonas putida. - PubMed - NCBI
Mechanism of ultraviolet light induced catabolite repression of L-arabinose isomerase (Journal Article) | ETDEWEB
Unlike catabolite repression by glucose, no small molecular weight compound is involved in U.V. light induced inhibition of the ... Unlike catabolite repression by glucose, no small molecular weight compound is involved in U.V. light induced inhibition of the ... ETDEWEB / Search Results / Mechanism of ultraviolet light induced catabolite repression of L-arabinose isomerase ... An attempt has been made to find out how U.V. irradiation of E.coli B/r cells causes catabolite repression to inhibit L- ...
Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria. - PubMed - NCBI
The Saccharomyces cerevisiae RTG2 Gene Is a Regulator of Aconitase Expression Under Catabolite Repression Conditions | Genetics
This gene is subject to catabolite repression; the ACO1 mRNA level is further reduced when glutamate is supplied with glucose. ... We identified a gene required for wild-type expression of ACO1 only under catabolite repression conditions. Sequencing of the ... The Saccharomyces cerevisiae RTG2 Gene Is a Regulator of Aconitase Expression Under Catabolite Repression Conditions. Christian ... The Saccharomyces cerevisiae RTG2 Gene Is a Regulator of Aconitase Expression Under Catabolite Repression Conditions. Christian ...
Characterization of Escherichia coli Flagellar Mutants That are Insensitive to Catabolite Repression | Journal of Bacteriology
Characterization of Escherichia coli Flagellar Mutants That are Insensitive to Catabolite Repression. Michael Silverman, Melvin ... Their synthesis was depressed in strains grown under conditions of catabolite repression. The presence of the cfs mutation ... In Escherichia coli, the synthesis of the flagellar organelle is sensitive to catabolite repression. Synthesis requires the ... Characterization of Escherichia coli Flagellar Mutants That are Insensitive to Catabolite Repression ...
"Mechanism of Catabolite Repression In The Archaeon Sulfolobus solfatar" by Yukari Maezato
Carbon catabolite repression (CCR) is a strategy to ensure optimal carbon metabolism. In this study, we employed Sulfolobus ... Mechanism of Catabolite Repression In The Archaeon Sulfolobus solfataricus. Yukari Maezato, University of Nebraska - Lincoln. ... Carbon catabolite repression (CCR) is a strategy to ensure optimal carbon metabolism. In this study, we employed Sulfolobus ... Maezato, Yukari, "Mechanism of Catabolite Repression In The Archaeon Sulfolobus solfataricus" (2012). ETD collection for ...
Structure Cluster
- 1MO1: CRYSTAL STRUCTURE AT 1.8 ANGSTROMS OF SELENO METHIONYLED CRH, THE BACILLUS SUBTILIS...
Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei | Journal of...
Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei María José ... 1997) Catabolite repression in Lactobacillus casei ATCC 393 is mediated by CcpA. J. Bacteriol. 179:6657-6664. ... Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei ... Elements Involved in Catabolite Repression and Substrate Induction of the Lactose Operon in Lactobacillus casei ...
CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) (AA 1-388) protein (His tag)</span...
Recombinant CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) Protein (His tag). Species: Xenopus laevis. Source: Yeast. Order ... CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) Background Recommended name: Nocturnin.. Alternative name(s): Rhythmic ... CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) show synonyms for this antigen * CCR4L ... CCR4 Carbon Catabolite Repression 4-Like (CCRN4L) (AA 1-388) protein (His tag). Details for Product No. ABIN1477485 ...
Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia...
... insensitive to catabolite repression, and (b) that transient repression is an exceptionally severe form of catabolite ... M. D. Yudkin; Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ... All of the 19 p−recombinants tested proved to suffer no transient repression, whereas all of the eight p+recombinants tested ...
CcpA mediates the catabolite repression of tst in Staphylococcus aureus - Zurich Open Repository and Archive
Seidl, K; Bischoff, M; Berger-Bächi, B (2008). CcpA mediates the catabolite repression of tst in Staphylococcus aureus. ... We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst ... We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst ... whereas glucose repression was abolished in the corresponding DeltaccpA mutant. Stabilizing the pH ruled out a pH effect due to ...
DIGITAL.CSIC: Isolation of the MIG1 gene from Candida albicans and effects of its disruption on catabolite repression
Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial...
One of the best characterized of these is the process by which the PTS regulates inducer uptake and catabolite repression. ... Although the PTS-mediated regulation of cyclic AMP synthesis (catabolite repression) is not as well defined from a mechanistic ... Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial ... Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial ...
The Yeast GATA Factor Gat1 Occupies a Central Position in Nitrogen Catabolite Repression-Sensitive Gene Activation | Molecular...
Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in ... Nitrogen catabolite repression (NCR) restrains the yeasts capacity to use poor nitrogen sources when rich ones are available. ... The Yeast GATA Factor Gat1 Occupies a Central Position in Nitrogen Catabolite Repression-Sensitive Gene Activation. Isabelle ... Saccharomyces cerevisiae GATA sequences function as TATA elements during nitrogen catabolite repression and when Gln3p is ...
The creC carbon catabolite repression gene of Aspergillus nidulans encodes a protein containing WD40 repeats. | Aspergillus &...
Yarrowia Lipolytica Yeast Possesses An Atypical Catabolite Repression
Catabolite repression was thoroughly studied in the bacterium Escherihia coli and, though not so well, in the yeast ... Yarrowia Lipolytica Yeast Possesses An Atypical Catabolite Repression. Catabolite repression was thoroughly studied in the ... Glucose Repression (Catabolite Repression) in Yeast. In: Yeast Sugar Metabolism. Biochemistry, Genetics, Biotechnology and ... but there are different circuits of repression for different groups of genes (2). Catabolite repression allows the respective ...
The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli |...
The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli. J ... 1. The specific role of the lac repressor (i-gene product) in transient catabolite repression evoked by the introduction of ... The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli ... The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli ...
Machine learning techniques to identify putative genes involved in nitrogen catabolite repression in the yeast Saccharomyces...
Nitrogen catabolite repression (NCR) refers to this selection mechanism. All known nitrogen catabolite pathways are regulated ... Nitrogen catabolite repression (NCR) refers to this selection mechanism [1, 2]. More specifically, NCR inhibits the ... Yeast Gene Variable Selection Method Bioinformatics Study Good Nitrogen Source Nitrogen Catabolite Repression ... Machine learning techniques to identify putative genes involved in nitrogen catabolite repression in the yeast Saccharomyces ...
Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia...
... insensitive to catabolite repression, and (b) that transient repression is an exceptionally severe form of catabolite ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ... Effect of point mutations in the lac promoter on transient and severe catabolite repression of the lac operon of Escherichia ...
Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae, Russian Journal of...
"Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae, Russian Journal of ... Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae. Padkina, M.; Tarasov ... Effect of the pho85 Mutation on Catabolite Repression of the CIT1 Gene in Yeasts Saccharomyces cerevisiae. Effect of the pho85 ... lp/springer_journal/effect-of-the-pho85-mutation-on-catabolite-repression-of-the-cit1-gene-6C0GSS0Klj ...
A constitutive catabolite repression mutant of a recombinant Saccharomyces cerevisiae strain improves xylose consumption during...
A constitutive catabolite repression mutant of a recombinant Saccharomyces cerevisiae strain improves xylose consumption during ... The aim of this work was to develop constitutive catabolite repression mutants in a xylose-utilising recombinant Saccharomyces ... Constitutive catabolite repressed strain YCR17 grew four-fold better on xylose in aerobic conditions than the control strain ... This study shows that a constitutive catabolite repressed mutant could be used to enhance the xylose consumption rate even in ...
catabolite repression
Repression in E. coli is partially relieved if cAMP is bound to the cAMP catabolite… 📐 📓 📒 📝 ... catabolite repression - catabolite repression. См. глюкозный эффект. (Источник: «Англо русский толковый словарь генетических ... Repression in E. coli is partially relieved if cAMP is bound to the cAMP-catabolite activator protein (cAMP receptor protein; ... catabolite repression. Inducible enzyme systems in some microorganisms (such as the lac operon) that are repressed when a more ...
Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR<...
Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR. Proceedings of the ... Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR. / Sievert, Christian ... title = "Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR", ... T1 - Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR ...
Catabolite Repression and Induction of Beta-galactosidase Synthesis Lab Report
"Catabolite Repression and Induction of Beta-galactosidase Synthesis Lab Report", n.d.). Catabolite Repression and Induction of ... Catabolite Repression and Induction of Beta-Galactosidase Synthesis Lab Report). Catabolite Repression and Induction of Beta- ... The paper "Catabolite Repression and Induction of Beta-galactosidase Synthesis" demonstrates both catabolite repression and ... Extract of sample "Catabolite Repression and Induction of Beta-galactosidase Synthesis". Download file to see previous pages ...
Catabolite repression and virulence gene expression in Listeria monocytogenes<...
Catabolite repression and virulence gene expression in Listeria monocytogenes. / Gilbreth, Stefanie Evans; Benson, Andrew K.; ... Catabolite repression and virulence gene expression in Listeria monocytogenes. Stefanie Evans Gilbreth, Andrew K. Benson, ... Gilbreth, S. E., Benson, A. K., & Hutkins, R. W. (2004). Catabolite repression and virulence gene expression in Listeria ... Catabolite repression and virulence gene expression in Listeria monocytogenes. Current Microbiology. 2004 Aug;49(2):95-98. ...
Carbon catabolite repression in Thermoanaerobacterium saccharolyticum | Biotechnology for Biofuels | Full Text
We report the initial characterization of the carbon catabolite repression system in this organism. We find that sugar ... Jankovic I, Bruckner R: Carbon catabolite repression by the catabolite control protein CcpA in Staphylococcus xylosus . J Mol ... Carbon catabolite repression in Bacillus subtilis: quantitative analysis of repression exerted by different carbon sources. J ... Gorke B, Stulke J: Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol ...
EscherichiaRegulated by carbon catabolite repressionGenesBacillusSynthesisRepressor activatorSaccharomycesForm of catabolite repressionMechanism of catabolite repressionPhenomenon of catabolite repressionBacteriaPathwaysRegulatoryCcpATransient repressionColiYeastCatabolicOperonRegulationRegulatorPhosphotransferase systemMetabolismRegulatesGlucose-mediatedAcetyl-CoA synthethasePathwayOperonsTranscriptionCarbon sourcesPromoterGene expressionCharacterizationAspergillusPseudomonasXyloseDegradationControlMicroorganismsStrainsSugarsConstitutiveUptakeBind
Escherichia7
- Catabolite repression was extensively studied in Escherichia coli . (wikipedia.org)
- Until recently, only one mechanism of catabolite repression in bacteria, a mechanism dependent on the cyclic AMP receptor protein of Escherichia coli, was understood in molecular detail. (nih.gov)
- The genome of the soil bacterium Pseudomonas putida KT2440 encodes singular orthologues of genes crp (encoding the catabolite repression protein, Crp) and cyaA (adenylate cyclase) of Escherichia coli. (nih.gov)
- In Escherichia coli , the synthesis of the flagellar organelle is sensitive to catabolite repression. (asm.org)
- 1. The specific role of the lac repressor (i-gene product) in transient catabolite repression evoked by the introduction of glucose into the medium has been investigated in Escherichia coli by using mutants of the i-gene. (biochemj.org)
- Relaxation of catabolite repression in streptomycin-dependent Escherichia coli. (thefreedictionary.com)
- A quantitative approach to catabolite repression in Escherichia coli . (springer.com)
Regulated by carbon catabolite repression1
- The transcriptome appeared to be regulated by carbon catabolite repression. (pnas.org)
Genes19
- Catabolite repression is considered to be a part of global control system and therefore it affects more genes rather than just lactose gene transcription. (wikipedia.org)
- We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst transcription may be regulated by the catabolite control protein CcpA. (uzh.ch)
- By introducing tst-genes under their native promoter or tst-promoter-reporter gene fusions in wild type strain Newman, we showed that glucose was able to repress tst transcription and TSST-1 production, whereas glucose repression was abolished in the corresponding DeltaccpA mutant. (uzh.ch)
- Many microbial genes are subject to carbon catabolite repression (CCR), the repression in the presence of a preferred carbon source (e.g. glucose, sucrose) of the genes required for growth in the presence of less favourable carbon sources (e.g. acetamide, proline, quinate). (aspergillus.org.uk)
- The different sugars produce signals which modify the conformation of certain proteins that, in turn, directly or through a regulatory cascade affect the expression of the genes subject to catabolite repression. (jbsdonline.com)
- These genes are not all controlled by a single set of regulatory proteins (3, 4), but there are different circuits of repression for different groups of genes (2). (jbsdonline.com)
- Since the expression of major catabolite repression-related genes did not show significant differences between MCD4 and AK46, these results showed that the higher maltose fermentative ability of MCD4 is due to the activation of MAL genes encoding two maltose permeases and two α-glucosidases. (mdpi.com)
- Abstract Expression of pectinolytic genes is regulated by catabolic repression limiting the production of pectin lyase (PL) if the natural inducer, pectin , is missing from the growth medium. (bvsalud.org)
- In our previous study, QU25 exhibited apparent CCR in a glucose-xylose mixture phenotypically, and transcriptional repression of the xylose operon encoding initial xylose metabolism genes, likely occurred in a CcpA-dependent manner. (elsevier.com)
- Hence, the metabolism of xylose in the presence of cellobiose by QU25 may have been due to 1) sufficient amounts of proteins encoded by the xylose operon genes for xylose metabolism despite of the slight repression of the operon, and 2) bypassing of the pentose-phosphate pathway without the TalC activity. (elsevier.com)
- The inhibition of gliding development in the presence of glucose was due, at least in part, to the repression of the genes pilT and pilD, whose products are essential for TFP-dependent gliding proficiency. (okstate.edu)
- The presence of preferred carbon sources often prevents the utilization of secondary substrates by the regulatory mechanisms, including transcription activation or repression of certain genes concerned with the use of alternative carbon sources, which is called carbon catabolite repression (CCR) [ 11 , 12 ]. (biomedcentral.com)
- On the other hand, Cra generally regulates carbon flux through by repression of genes encoding glycolytic pathway enzymes, or by activating key genes involved in the Krebs cycle, glyoxylate shunt, gluconeogenic pathways and electron transfer [ 16 ]. (biomedcentral.com)
- When the cell is exposed to carbohydrate mixtures, the PTS prevents the expression of catabolic genes and activity of non-PTS sugars transport systems by carbon catabolite repression (CCR). (nih.gov)
- cAMP, in turn, is required for the catabolite activator protein (CAP) to bind to DNA and activate the transcription of the lac operon, which includes genes necessary for lactose metabolism. (wikipedia.org)
- Mig1 is a Cys2-His2 zinc finger protein that mediates glucose repression of several genes by binding to their promoters and recruiting the general repression complex Ssn6-Tup1. (semanticscholar.org)
- Genes subject to glucose repression were mainly involved in the metabolism of alternative carbon sources including the control of glycerol uptake and metabolism. (biomedcentral.com)
- Peroxisomal and methanol utilization genes were confirmed to be subject to carbon substrate repression in excess glucose or glycerol, but were found to be strongly de-repressed in limiting glucose-conditions (as are often applied in fed batch cultivations) in addition to induction by methanol. (biomedcentral.com)
- In contrast, mutants impaired in the glucose-mediated repression of genes were 2DG resistant because glucose availability transcriptionally repressed DOG2 by inhibiting signaling mediated by the AMPK ortholog Snf1. (sciencemag.org)
Bacillus8
- Gram positive bacteria such as Bacillus subtilis have a cAMP -independent catabolite repression mechanism controlled by catabolite control protein A ( CcpA ). (wikipedia.org)
- The second such mechanism, found in Bacillus subtilis, involves a catabolite-activated, ATP-dependent protein kinase that phosphorylates a specific seryl residue in the small phosphocarrier protein, HPr, of the phosphotransferase system. (nih.gov)
- One form of catabolite repression (CR) in the Gram-positive genus, Bacillus, is mediated by a cis-acting element (CRE). (nih.gov)
- The overcoming of catabolite repression, in bioinsecticides production by sporeless Bacillus thuringiensisstrain S22 was investigated into fully controlled 3 L fermenter, using glucose based medium. (edu.qa)
- Saoussen Ben Khedher, Samir Jaoua, and Nabil Zouari, "Overcome of Carbon Catabolite Repression of Bioinsecticides Production by Sporeless Bacillus thuringiensis through Adequate Fermentation Technology," Biotechnology Research International, vol. 2014, Article ID 698587, 8 pages, 2014. (edu.qa)
- Insertional mutagenesis was conducted on Bacillus subtilis cells to screen for mutants resistant to catabolite repression. (elsevierpure.com)
- Catabolite repression in Bacillus subtilis: a global regulatory mechanism for the gram-positive bacteria? (psu.edu)
- Rapoport G: Two different mechanisms mediate catabolite repression of the Bacillus subtilis levanase operon - Martin-Verstraete, Stülke, et al. (psu.edu)
Synthesis17
- When glucose is available in the environment, the synthesis of β-galactosidase is under repression due to the effect of catabolite repression caused by glucose. (wikipedia.org)
- Measurements of intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentrations in E. coli under a variety of conditions show that levels of this nucleotide are well correlated with the rate of synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) in both catabolite repression and transient repression. (pnas.org)
- These results, combined with extensive genetic and in vitro studies from a number of laboratories on the role of cAMP in E. coli, provide strong support for the concept that intracellular cAMP levels mediate the effects of catabolite and transient repression on rates on enzyme synthesis. (pnas.org)
- An attempt has been made to find out how U.V. irradiation of E.coli B/r cells causes catabolite repression to inhibit L-arabinose isomerase synthesis. (osti.gov)
- misc{etde_6096134, title = {Mechanism of ultraviolet light induced catabolite repression of L-arabinose isomerase} author = {Bhatnagar, D, and Bhattacharya, A K} abstractNote = {An attempt has been made to find out how U.V. irradiation of E.coli B/r cells causes catabolite repression to inhibit L-arabinose isomerase synthesis. (osti.gov)
- The presence of the mutation resulted in flagella synthesis in Cya and Crp strains as well as in the wild type grown under conditions of catabolite repression. (asm.org)
- Their synthesis was depressed in strains grown under conditions of catabolite repression. (asm.org)
- We suggest that the formation of the flaI gene product is the step in flagellar synthesis that is catabolite sensitive and requires cAMP. (asm.org)
- In this diploid the synthesis of thiogalactoside transacetylase suffered transient repression but the synthesis of β-galactosidase did not. (portlandpress.com)
- Although the PTS-mediated regulation of cyclic AMP synthesis (catabolite repression) is not as well defined from a mechanistic standpoint, a model involving allosteric activation of adenylate cyclase by phospho-IIIGlc, together with the evidence supporting it, is presented. (asm.org)
- Download file to see previous pages Apart from induction, synthesis rate is determined by catabolite repression, whereby it slows down the synthesis of beta-galactosidase especially in the presence of a better carbon (and energy) source, such as glucose. (studentshare.org)
- Apart from induction, synthesis of β-galactosidase is also influenced by catabolite repression. (studentshare.org)
- Catabolite Repression and Induction of Beta-Galactosidase Synthesis Lab Report", n.d. https://studentshare.org/biology/1685209-writers-choice. (studentshare.org)
- In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. (microbiologyresearch.org)
- This was indicated by acetate synthesis pathways PTA-ACKA and POXB component expression down-regulation before the overflow switch at μ = 0.27 ± 0.02 h -1 with concurrent 5-fold stronger repression of acetate-consuming Acs. (biomedcentral.com)
- Effect of specific growth rate on acetate synthesis and utilization pathways, selected TCA cycle and carbon catabolite repressed gene and protein expression levels in E. coli A-stat experiments . (biomedcentral.com)
- Biotrophy may also depend on additional controls, such as catabolite repression of CWDE synthesis resulting from the characteristic influx of photosynthates to infected areas (Cooper, 1983). (thefreedictionary.com)
Repressor activator4
- Note that E. coli has a similar cAMP-independent catabolite repression mechanism that utilizes a protein called catabolite repressor activator (Cra). (wikipedia.org)
- One such mechanism, found in E. coli, involves the catabolite repressor/activator (Cra) protein (formerly designated the fructose repressor FruR) which represses sugar catabolic systems and activates sugar anabolic systems. (nih.gov)
- The gene encoding catabolite repressor/activator (Cra) was deleted in the genome of E. aerogenes to increase the fructose consumption rate. (biomedcentral.com)
- In enteric bacteria, two dominant CCR mechanisms involve transcriptional regulation by cyclic AMP receptor protein (Crp) and by catabolite repressor/activator (Cra) [ 13 ]. (biomedcentral.com)
Saccharomyces2
- Catabolite repression was thoroughly studied in the bacterium Escherihia coli and, though not so well, in the yeast Saccharomyces cerevisiae (1, 2). (jbsdonline.com)
- The aim of this work was to develop constitutive catabolite repression mutants in a xylose-utilising recombinant Saccharomyces cerevisiae strain and evaluate the differences in xylose consumption under fermentation conditions. (sun.ac.za)
Form of catabolite repression1
- 6. These and previously reported results can be explained by assuming ( a ) that both mutations L8 and L29 render the lac promoter partially, but not completely, insensitive to catabolite repression, and ( b ) that transient repression is an exceptionally severe form of catabolite repression. (portlandpress.com)
Mechanism of catabolite repression1
- It is therefore concluded that the mechanism of catabolite repression induced by U.V. appears to be different from that of the catabolite repression by glucose. (osti.gov)
Phenomenon of catabolite repression2
- The phenomenon of catabolite repression in Yarrowia lipolytica yeast is poorly studied. (jbsdonline.com)
- We conclude that B. subtilis possesses at least two distinct routes of glucose entry, both of which contribute to the phenomenon of catabolite repression. (elsevierpure.com)
Bacteria7
- Carbon catabolite repression , or simply catabolite repression , is an important part of global control system of various bacteria and other micro-organisms. (wikipedia.org)
- The characterization of these novel mechanisms establishes that cyclic AMP-independent catabolite control is operative in bacteria, and that multiple mechanisms of catabolite control evolved independently of each other. (nih.gov)
- Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria. (nih.gov)
- Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. (microbiologyresearch.org)
- Generally, Firmicutes bacteria show preferential consumption of sugar (usually glucose), termed carbon catabolite repression (CCR), while hampering the catabolism of other sugars. (elsevier.com)
- A novel protein kinase that controls carbon catabolite repression in bacteria. (ebi.ac.uk)
- Catabolite repression and inducer control in Gram-positive bacteria. (psu.edu)
Pathways7
- All known nitrogen catabolite pathways are regulated by four regulators. (springer.com)
- The ultimate goal is to infer the complete nitrogen catabolite pathways. (springer.com)
- Crc (catabolite repression control) protein of Pseudomonas aeruginosa has shown to be involved in carbon regulation of several pathways. (ecu.edu)
- The presence of protocatechuate caused transcriptional repression of the vanA , B - and hca -encoded funnelling pathways (vertical regulation). (microbiologyresearch.org)
- However, the sugar mixture in sugarcane molasses is not consumed as efficiently as glucose in microbial fermentation due to complex interactions among their utilizing pathways, such as carbon catabolite repression (CCR). (biomedcentral.com)
- Glucose exerts its dramatic effects upon S. cerevisiae physiology via signaling pathways that include the glucose repression (Snf1 AMP kinase) pathway, cyclic AMP (cAMP)-protein kinase A signaling, and the sugar receptor repressor (Snf3-Rgt2) pathway (for reviews, see references 7 to 12 ). (asm.org)
- Moreover, in the case of yeast, D-xylose may provide a better feedstock for the production of bioproducts other than ethanol, because the relevant pathways are not subject to glucose-dependent repression. (springer.com)
Regulatory7
- Regulatory exaptation of the catabolite repression protein (Crp)-cAMP system in Pseudomonas putida. (nih.gov)
- Garcia, Preston Philip, "Control of succinate-mediated catabolite repression through a two-component regulatory system in Sinorhizobium meliloti" (2008). (uconn.edu)
- Our results demonstrate that carbon catabolite regulation constitutes an important physiological regulatory mechanism that reduces the proficiencies of the gliding motilities of a large number of unrelated human- and animal-derived pathogenic C. perfringens strains. (okstate.edu)
- The inhibitory effects of glucose on pilT and pilD expression were under the control of the key regulatory protein CcpA (catabolite control protein A). The deficiency in CcpA activity of a ccpA knockout C. perfringens mutant strain restored the expressions of pilT and pilD and gliding proficiency in the presence of 1% glucose. (okstate.edu)
- IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. (thefreedictionary.com)
- Hfq of the opportunistic pathogen inhibits translation of target transcripts by forming a regulatory complex with the catabolite repression protein Crc. (pdbj.org)
- RT "CreA mediates repression of the regulatory gene xlnR which controls RT the production of xylanolytic enzymes in Aspergillus nidulans. (genome.jp)
CcpA6
- Full expression of lacTEGF was found only in a man ccpA double mutant, indicating that PTS elements are involved in the CcpA-independent catabolite repression mechanism probably via LacT. (asm.org)
- The catabolite control protein CcpA binds to P mga and influences expression of the virulence regulator Mga in the Group A streptococcus. (microbiologyresearch.org)
- The carbon catabolite repression of the gliding motility of the ccpA mutant strain was restored after the introduction of a complementing plasmid harboring a wild-type copy of ccpA. (okstate.edu)
- These results point to a central role for CcpA in orchestrating the negative effect of carbon catabolite regulation on C. perfringens gliding motility. (okstate.edu)
- Furthermore, we discovered a novel positive role for CcpA in pilT and pilD expression and gliding proficiency in the absence of catabolite regulation. (okstate.edu)
- Carbon catabolite repression of gliding motility and the dual role of CcpA, either as repressor or as activator of gliding, are analyzed in the context of the different social behaviors and diseases produced by C. perfringens. (okstate.edu)
Transient repression3
- 1. Experiments were devised to show whether the point mutations L8 and L29 in the lac promoter alleviate transient repression. (portlandpress.com)
- All of the 19 p − recombinants tested proved to suffer no transient repression, whereas all of the eight p + recombinants tested suffered prolonged transient repression. (portlandpress.com)
- 4. Insertion of Flaci + into this strain restores both inducibility and transient repression. (biochemj.org)
Coli3
- The two amino acid substitutions in XylR enhance xylose utilization and release glucose-induced repression in different E. coli hosts, including wild type, suggesting its potential wide application in industrial E. coli biocatalysts. (elsevier.com)
- Inhibition de l'adaptation Enzymatique chez B. Coli en Présence de 2-4 Dinitrophénol. (elsevier.com)
- The dual-layered catabolite repression was identified and successfully removed in the engineered E. coli , and the compound ( R )-3-hydroxybutyric acid was produced from simultaneous assimilation of glucose, xylose and arabinose. (diva-portal.org)
Yeast2
- Catabolite repression (of the respiratory system) is seen in yeast in high glucose concentrations, though the mechanism is different. (enacademic.com)
- Yeast carbon catabolite repression. (semanticscholar.org)
Catabolic1
- Identified XylR variants (R121C and P363S) have a higher affinity to their DNA binding sites, leading to a xylose catabolic activation independent of catabolite repression control. (elsevier.com)
Operon3
- cAMP binds to catabolite activator protein (CAP) and together they will bind to a promoter sequence on the lac operon . (wikipedia.org)
- DNA binding of the complex in turn promotes catabolite repression or catabolite activation, depending on the target operon. (nih.gov)
- It has previously been reported ( 22 , 34 ) that the expression of the lac operon in L. casei ATCC 393[pLZ15 − ] is subject to dual regulation: carbon catabolite repression (CR) and induction by lactose through transcriptional antitermination. (asm.org)
Regulation6
- Since carbon catabolite regulation has been implicated in the control of different bacterial behaviors, we investigated the effects of glucose and other readily metabolized carbohydrates on C. perfringens gliding motility. (okstate.edu)
- Enzyme production regulation is influenced by catabolite repression. (thefreedictionary.com)
- We do not imply that catabolite regulation is the sole basis for this effect, but rather that catabolite regulation may be indirect, since the major evolutionary benefit derived from catabolite repressive mechanism may have resulted in enhancing the endophyte's ability to efficiently scavenge nutrients from such a nutrient poor location, thereby avoiding the usual cellular invasive, destructive mode for obtaining nutrient used by most biotrophic pathogenic fungi. (thefreedictionary.com)
- The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. (genecards.org)
- Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. (genecards.org)
- Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression . (wikipedia.org)
Regulator3
- To determine whether virulence gene expression was also influenced by catabolite repression, we performed primer extension experiments, using primers for hly and prfA, which encode for a hemolysin and the regulator protein PrfA, respectively. (nebraska.edu)
- SIP1 is a Catabolite Repression-Specific Negative Regulator of GAL Gen" by Larry M. Mylin, V. L. Bushman et al. (messiah.edu)
- These studies show that SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. (messiah.edu)
Phosphotransferase system2
- The catabolite repression in this case is achieved through the utilization of phosphotransferase system . (wikipedia.org)
- Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system. (asm.org)
Metabolism3
- Carbon catabolite repression (CCR) is a strategy to ensure optimal carbon metabolism. (unl.edu)
- We believe that this two component system may use sensory information about redox levels or energy state gathered from the PAS domains of Sma0113 to modulate electron flow and metabolism by catabolite repression. (uconn.edu)
- Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. (illumina.com)
Regulates3
- One of the best characterized of these is the process by which the PTS regulates inducer uptake and catabolite repression. (asm.org)
- Crc regulates the expression of branched-chain keto acid dehydrogenase, glucose-6-phosphate dehydrogenase, and amidase in both species but not urocanase, although the carbon sources responsible for catabolite repression in the two species differ. (ecu.edu)
- These findings suggest a model in which the Snf1 kinase positively regulates Flo11-dependent developmental events by antagonizing Nrg-mediated repression of the FLO11 gene. (asm.org)
Glucose-mediated1
- The endo-acting [beta]-glucanase secretion is controlled by glucose-mediated catabolite repression and induced mainly by media containing cell-wall materials. (thefreedictionary.com)
Acetyl-CoA synthethase2
- The first step in acetate overflow switch (at μ = 0.27 ± 0.02 h -1 ) is the repression of acetyl-CoA synthethase (Acs) activity triggered by carbon catabolite repression resulting in decreased assimilation of acetate produced by phosphotransacetylase (Pta), and disruption of the PTA-ACS node. (biomedcentral.com)
- As Schizochytrium is a slow growing heterotroph consuming glucose at a slow rate, wai cultivation in a non carbon catabolite repression condition or in an increased acetyl-CoA synthethase state gives rise to higher growth and glucose consumption rates (27). (thefreedictionary.com)
Pathway2
- Multiple operons feeding into the β -ketoadipate pathway are controlled by carbon catabolite repression (CCR) caused by succinate plus acetate. (microbiologyresearch.org)
- Thickness of red arrows denotes level of ACS and PTA-ACKA pathway repression (thick line represents stronger repression). (biomedcentral.com)
Operons2
- The bkd operons of P. putida and P. aeruginosa encode the inducible multienzyme complex branched-chain keto acid dehydrogenase, which is regulated in both species by catabolite repression. (ecu.edu)
- The Crc ( c atabolite r epression c ontrol) protein is involved in repression of all operons (except for catA ), as demonstrated by the analysis of respective crc strains. (microbiologyresearch.org)
Transcription1
- Dal80-dependent repression of NCR-sensitive gene expression occurred at three possible levels: Dal80 represses GAT1 expression, it competes with Gat1 for binding, and it directly represses NCR gene transcription. (asm.org)
Carbon sources2
- However, the term "glucose effect" is actually a misnomer since other carbon sources are known to induce catabolite repression. (wikipedia.org)
- The phenomenon of using succinate as the sole carbon source in the presence of secondary carbon sources is termed Succinate Mediated Catabolite Repression (SMCR). (uconn.edu)
Promoter1
- A low-molecular-weight (about 34 kDa) protein was identified and shown to interact with a region of the CIT1gene promoter (from -367 to -348 bp), which controls the glucose repression. (deepdyve.com)
Gene expression1
- We have isolated the SIP1 gene as a multicopy suppressor of the gal83-associated defect in glucose repression of GAL gene expression. (messiah.edu)
Characterization1
- We report the initial characterization of the carbon catabolite repression system in this organism. (biomedcentral.com)
Aspergillus3
- The creC carbon catabolite repression gene of Aspergillus nidulans encodes a protein containing WD40 repeats. (aspergillus.org.uk)
- Nuclear export-dependent degradation of the carbon catabolite repressor CreA is regulated by a region located near the C-terminus in Aspergillus oryzae. (semanticscholar.org)
- RT "Carbon catabolite repression of the Aspergillus nidulans xlnA gene. (genome.jp)
Pseudomonas1
- In this study, the role of Crc in catabolite repression control has been studied in Pseudomonas putida. (ecu.edu)
Xylose3
- Constitutive catabolite repressed strain YCR17 grew four-fold better on xylose in aerobic conditions than the control strain YUSM. (sun.ac.za)
- This study shows that a constitutive catabolite repressed mutant could be used to enhance the xylose consumption rate even in the presence of high glucose in the fermentation medium. (sun.ac.za)
- Three of these strains were catabolite repression mutants (ptsG**-) that have the ability to simultaneously ferment glucose and xylose. (usda.gov)
Degradation1
- However, when expressed in C. albicans , S. cerevisiae Icl1 (ScIcl1) is subjected to glucose-accelerated degradation, indicating that like S. cerevisiae , this pathogen has the molecular apparatus required to execute ubiquitin-dependent catabolite inactivation. (asm.org)
Control1
- These mutants suggested that catabolite repression in pseudomonads might, in part, involve control of BkdR levels. (ecu.edu)
Microorganisms3
- Catabolite repression allows microorganisms to adapt quickly to a preferred (rapidly metabolizable) carbon and energy source first. (wikipedia.org)
- Catabolite repression allows the respective microorganisms effectively use carbohydrate substrates, which first assimilate one of the two available substrates (commonly, a carbohydrate), whereas the assimilation of the other substrate starts only after the first substrate is fully consumed from the medium. (jbsdonline.com)
- The degree of catabolite repression varies very significantly in microorganisms. (jbsdonline.com)
Strains1
- 5. The same diploid strains were used in experiments to show whether mutations L8 and L29 alleviate the severe catabolite repression caused by growth in glucose plus gluconate. (portlandpress.com)
Sugars2
- Only when glucose was consumed were these sugars fermented, indicating that catabolite repression by glucose had occurred. (nebraska.edu)
- The order in which sugars are utilized is frequently determined by a mechanism known as carbon catabolite repression (CCR) [ 1 ]. (biomedcentral.com)
Constitutive2
- At 42° it is about 20% constitutive and transient catabolite repression is abolished. (biochemj.org)
- 3. A strain carrying an amber suppressor-sensitive mutation in the i-gene is phenotypically constitutive and also fails to show transient catabolite repression. (biochemj.org)
Uptake2
- Tn10 mutation (i) partially but specifically relieved glucose- and sucrose-promoted catabolite repression, (ii) reduced the growth rate in minimal glucose medium, and (iii) reduced rates of [ 14 C]glucose and [ 14 C]methyl α-glucoside uptake. (elsevierpure.com)
- It may be the only lactate uptake porter and is subject to glucose catabolite repression. (tcdb.org)
Bind1
- When catabolites bind to Cra, Cra dissociates from the DNA causing catabolite activation and catabolite repression, respectively. (nih.gov)