Autoimmune Lymphoproliferative Syndrome: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Lymphoproliferative Disorders: Disorders characterized by proliferation of lymphoid tissue, general or unspecified.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Antigens, CD95: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Caspase 10: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Caspase 8: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.Caspase 9: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.Colorimetry: Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Cysteine Proteases: A subclass of peptide hydrolases that depend on a CYSTEINE residue for their activity.Cysteine Endopeptidases: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Cysteine Proteinase Inhibitors: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Dominica: An island republic of the West Indies. Its capital is Roseau. It was discovered in 1493 by Columbus and held at different times by the French and the British in the 18th century. A member of the West Indies Federation, it achieved internal self-government in 1967 but became independent in 1978. It was named by Columbus who discovered it on Sunday, Domingo in Spanish, from the Latin Dominica dies, the Lord's Day. (From Webster's New Geographical Dictionary, 1988, p338 & Room, Brewer's Dictionary of Names, 1992, p151)Streptomycin: An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.New HampshireOleanolic Acid: A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Staurosporine: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)Schools, Medical: Educational institutions for individuals specializing in the field of medicine.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).PicratesLipid Peroxidation: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.Malondialdehyde: The dialdehyde of malonic acid.
Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10. (1/114)Caspase-10/a (Mch4) and caspase-10/b (FLICE2) are related death effector domain-containing cysteine aspartases presumed to be at or near the apex of apoptotic signaling pathways. We report the cloning and characterization of two novel proteins that are splice isoforms of the caspase-10 family. Caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo. Caspase-10/c mRNA is specifically up-regulated upon TNF stimulation, suggesting a potential role of this isoform in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is a hybrid of the known caspases Mch4 and FLICE2, as it is identical to FLICE2 except for the small (p12) catalytic subunit, which is identical to Mch4. Caspase-10/d is proteolytically active in vitro and also induces cell death in vivo, although it is less active than Mch4. The mRNAs for all known isoforms of caspase-10 are abundantly expressed in fetal lung, kidney, and skeletal muscle but are very poorly expressed or absent in these tissues in the adult, implying a possible role for the caspase-10 family in fetal development. (+info)
Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. (2/114)T-cell apoptosis in inflammatory demyelinating lesions of chronic myelin oligodendrocyte glycoprotein peptide35-55 induced autoimmune encephalomyelitis was studied in several different gene knockout mice as well as their wild-type counterparts. The gene deletions included tumor necrosis factor (TNF) alpha, lymphotoxin, TNF receptor 1 or 2, Fas-L, inducible nitric oxide synthase, perforin, and interleukin1beta-converting enzyme. Impairment of the TNF receptor 1 pathway led to a 50% reduction of T-cell apoptosis in the central nervous system lesions, whereas the other genetic deletions showed no significant effect. Our study thus identified the TNF receptor 1 signaling pathway as one mechanism responsible for the removal of T lymphocytes from inflammatory demyelinating lesions of the central nervous system. (+info)
Caspases in T-cell receptor-induced thymocyte apoptosis. (3/114)Apoptosis eliminates inappropriate or autoreactive T lymphocytes during thymic development. Intracellular mediators involved in T-cell receptor (TCR)-mediated apoptosis in developing thymocytes during negative selection are therefore of great interest. Caspases, cysteine proteases that mediate mature T-cell apoptosis, have been implicated in thymocyte cell death, but their regulation is not understood. We examined caspase activities in distinct thymocyte subpopulations that represent different stages of T-cell development. We found caspase activity in CD4+CD8+ double positive (DP) thymocytes, where selection involving apoptosis occurs. Earlier and later thymocyte stages exhibited no caspase activity. Only certain caspases, such as caspase-3 and caspase-8-like proteases, but not caspase-1, are active in DP thymocytes in vivo and can be activated when DP thymocytes are induced to undergo apoptosis in vitro by TCR-crosslinking. Thus, specific caspases appear to be developmentally regulated in thymocytes. (+info)
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. (4/114)Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor independent missense mutations in Caspase 10. These encode amino acid substitutions that decrease caspase activity and interfere with death receptor-induced apoptosis, particularly that stimulated by Fas ligand and TRAIL. These results provide evidence that inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II. (+info)
Structure, expression, and function of the Xenopus laevis caspase family. (5/114)Caspases, a family of cysteine proteases, have been recognized as the central executors of programmed cell death. Nonetheless, the information on the caspase family has been limited to mammals, Drosophila, and nematodes. To examine the structure and characterization of the Xenopus caspase family, we have cloned the cDNAs encoding caspase-2 and -6-10 in addition to caspase-1 and -3, which we characterized previously (Yaoita, Y., and Nakajima, K. (1997) J. Biol. Chem. 272, 5122-5127). First, the existence of these caspases in frog suggests that the caspase cascades clarified in mammals are conserved at least from Amphibia. Interestingly, Xenopus caspase-1, -8, and -10 (especially caspase-8) showed a lower degree of identity to human equivalents than the other caspases. Second, mRNAs of many caspases increased during the climax of metamorphosis in regressing organs, tail, and intestine, where programmed cell death occurs, but not in apoptotic tail-derived cultured cells (XLT-15-11) treated with thyroid hormone, showing that new RNA synthesis of caspases is dispensable to programmed cell death. Third, comparison of human and Xenopus caspase sequences implies that some proposed regulations of human caspases are not conserved in frog. (+info)
Activation of the NF-kappaB pathway by caspase 8 and its homologs. (6/114)Caspase 8 is the most proximal caspase in the caspase cascade and has been known for its role in the mediation of cell death by various death receptors belonging to the TNFR family. We have discovered that Caspase 8 can activate the NF-kappaB pathway independent of its activity as a pro-apoptotic protease. This property is localized to its N-terminal prodomain, which contains two homologous death effector domains (DEDs). Caspase 10 and MRIT, two DEDs-containing homologs of Caspase 8, can similarly activate the NF-kappaB pathway. Dominant-negative mutants of the Caspase 8 prodomain can block NF-kappaB induced by Caspase 8, FADD and several death receptors belonging to the TNFR family. Caspase 8 can interact with multiple proteins known to be involved in the activation of the NF-kappaB pathway, including the serine-threonine kinases RIP, NIK, IKK1 and IKK2. Thus, DEDs-containing caspases and caspase homolog(s) may have functions beyond their known role in the mediation of cell death. Oncogene (2000) 19, 4451 - 4460. (+info)
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. (7/114)Disruption of apoptotic pathways may be involved in tumor formation, regression, and treatment resistance of neuroblastoma (NB). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in cancer cell lines, whereas normal cells are not sensitive to TRAIL-mediated apoptosis. In this study we analyzed the expression and function of TRAIL and its agonistic and antagonistic receptors as well as expression of cellular FLICE-like inhibitory protein and caspase-2, -3, -8, -9, and -10 in 18 NB cell lines. Semiquantitative RT-PCR revealed that TRAIL-R2 and TRAIL-R3 are the main TRAIL-receptors used by NB cells. Sensitivity to TRAIL-induced apoptosis did not correlate with mRNA expression of TRAIL receptors or cellular FLICE-like inhibitory protein. Surprisingly, caspase-8 and caspase-10 mRNA expression was detected in only 5 of 18 NB cell lines. Interestingly, only these five NB cell lines were susceptible to TRAIL-induced apoptosis in a time- and dose-dependent manner. Treatment with 5-aza-2'-deoxycytidine restored mRNA and protein expression of caspase-8 and TRAIL sensitivity of resistant cell lines, suggesting that gene methylation is involved in caspase inactivation. The TRAIL system seems to be functional in NB cells expressing caspase-8 and/or caspase-10. Because many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB. (+info)
Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease. (8/114)BACKGROUND: Proliferative breast disease (PBD) may increase a woman's risk of developing breast cancer, perhaps by decreasing cellular sensitivity to apoptosis. To determine whether resistance to apoptosis develops during PBD, we investigated apoptosis initiated through the Fas pathway in a series of cell lines that recapitulates the morphologic changes of PBD in nude/beige mice. METHODS: The series of cell lines used was MCF-10A cells (parental preneoplastic human breast epithelial cells), MCF-10AT cells (transformed with T(24) Ha-ras), and MCF-10ATG3B cells (derivative cells that progress to carcinoma). Fas-mediated apoptosis, induced when a Fas monoclonal antibody bound to and activated the Fas receptor on these cells, was assessed morphologically and by flow cytometry. Levels of proteins involved in Fas-mediated apoptosis and cleavage of poly(adenosine diphosphate-ribose) polymerase (PARP), an end product of caspase activation, were determined by immunoblotting. Bcl-2 and Bax heterodimerization was examined by coimmunoprecipitation. All statistical tests were two-sided. RESULTS: Sensitivity to Fas-mediated apoptosis decreased with the tumorigenic potential of cells: MCF-10A cells were extremely susceptible, MCF-10AT cells were less susceptible, and MCF-10ATG3B cells were resistant. The percentage of apoptotic cells declined, from 24% to 8% to 6%, respectively. All lines produced Fas ligand (FasL) and had comparable levels of Fas receptor, FasL, Fas-associated death-domain protein, and caspases 3 and 6. Levels of caspase 8 were similar in MCF-10A and MCF-10AT cells but about 30% lower in MCF-10ATG3B cells (P>.01 but <.05). Levels of caspase 10 were about 20% lower in MCF-10AT cells (P>.005 but <.01) and about 59% lower in MCF-10ATG3B cells than in MCF-10A cells (P>.01 but <.05). PARP cleavage was detected in MCF-10A and MCF-10AT cells but not in MCF-10ATG3B cells. Levels of Bax, Bid, and Bak proteins were similar in all lines, but levels of Bcl-2 were lower in MCF-10AT and MCF-10ATG3B cells than in MCF-A cells, and Bcl-2-Bax heterodimerization progressively declined in the series. CONCLUSION: Resistance to Fas-mediated apoptosis appears to develop progressively in the MCF-10AT cell series. (+info)
Autoimmune lymphoproliferative syndrome
Van Der Werff Ten Bosch, Jutte; Schotte, Peter; Ferster, Alice; Azzi, Nadira; Boehler, Thomas; Laurey, Genevieve; Arola, Mikko ... Fas and Fas-ligand interact to trigger the caspase cascade, leading to cell apoptosis. Patients with ALPS have a defect in this ... CEDS: Caspase 8 deficiency state. No longer considered a subtype of ALPS but distinct disorder ... 186 (10): 6035-43. doi:10.4049/jimmunol.1100021. PMC 3725553 . PMID 21490157.. [unreliable medical source?] ...
... initiating the caspase cascade. The activated caspases can go on to cleave intracellular proteins such as inhibitor of caspase- ... Activated caspase 8 cleaves these kinases, inhibiting necroptosis. Since activation of caspase 8 requires FADD in order to ... Caspase 8 then cleaves RIPK1, leading to inhibition of this signalling, inhibiting cell death. FADD knockout in mouse embryos ... FADD binds to ATG5 in a complex which also contains ATG12, Caspase 8 and RIPK1. The formation of this complex is stimulated by ...
"Entrez Gene: CARD10 caspase recruitment domain family, member 10". Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S ... Caspase recruitment domain-containing protein 10 is an enzyme that in humans is encoded by the CARD10 gene. The caspase ... "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and ... Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane- ...
There are two types of caspases: initiators and effectors. Initiator caspases cleave inactive forms of effector caspases. This ... 115 (10): 2610-7. doi:10.1172/JCI26321. PMC 1236695. PMID 16200193.. *^ a b c d e f g h i Caccamo D, et al. (2010). "Critical ... Pharmacological approaches involve inhibitors of caspase activity, and caspase inhibition might delay cell death in the ... This pathway controls the activation of caspase-9 by regulating the release of cytochrome c from the mitochondrial ...
Alcivar A, Hu S, Tang J, Yang X (Jan 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene. 22 (2 ... Alcivar A, Hu S, Tang J, Yang X (2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene. 22 (2): ... Schickling O, Stegh AH, Byrd J, Peter ME (2002). "Nuclear localization of DEDD leads to caspase-6 activation through its death ... DEDD has been shown to interact with: CFLAR, Caspase 8, and FADD. GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May ...
Death receptor 5
DR5 has been shown to interact with: Caspase 8, Caspase 10, FADD, and TRAIL. Monoclonal antibodies targeting DR5 have been ...
There are two types of caspases: initiators and effectors. Initiator caspases cleave inactive forms of effector caspases. This ... Pharmacological approaches involve inhibitors of caspase activity, and caspase inhibition might delay cell death in the ... This pathway controls the activation of caspase-9 by regulating the release of cytochrome c from the mitochondrial ... Caspases (cysteine-aspartic acid proteases) cleave at very specific amino acid residues. ...
... is a distinctive feature of DNA degraded by caspase-activated DNase (CAD), which is a key event during apoptosis ... Apoptotic DNA fragmentation Caspase-activated DNase Nicoletti assay TUNEL assay Wyllie AH (1980-04-10). "Glucocorticoid-induced ... caspase-3 activity by zinc supplementation in cultured HeLa cells". The Indian Journal of Medical Research. 129 (5): 579-586. ...
... has been shown to interact with: Abl gene, CBX2, Caspase 10, E2F2, E2F3, Mdm2, RING1, and YY1. "Human PubMed Reference ... 10 (2): 166-72. doi:10.1038/embor.2008.231. PMC 2637313 . PMID 19098711. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ...
There are two types of caspases: initiators and effectors. Initiator caspases cleave inactive forms of effector caspases. This ... 115 (10): 2610-7. doi:10.1172/JCI26321. PMC 1236695. PMID 16200193.. *^ a b c d e f g h i Caccamo D, et al. (2010). "Critical ... Pharmacological approaches involve inhibitors of caspase activity, and caspase inhibition might delay cell death in the ... This pathway controls the activation of caspase-9 by regulating the release of cytochrome c from the mitochondrial ...
It also selectively inhibits effector caspases 2, 3, 6, and 7 but not caspases 8 and 10. This compound has been shown to block ...
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ... 2005). "Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2". Structure. 12 (12): 2257-63. doi ... 15 (10): 4444-56. doi:10.1091/mbc.E04-04-0274. PMC 519139 . PMID 15229288. "Entrez Gene: RFFL ring finger and FYVE-like domain ...
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ... This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding ...
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ... 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375-81. doi:10.1038/nature02462 ...
He found mutations in the genes encoding Fas and Fas ligand, as well as caspase-10 and N-Ras, are associated with the disorder ... 10 (5): 115, PMC 2438277 , PMID 18596934 CS1 maint: Uses authors parameter (link) John F. Enders Lectureship, Infectious ...
Active caspase-8 is then released from the DISC into the cytosol, where it cleaves other effector caspases, eventually leading ... Caspase 8, Caspase 10, CFLAR, FADD, Fas ligand, PDCD6, and Small ubiquitin-related modifier 1. GRCh38: Ensembl release 89: ... In most cell types, caspase-8 catalyzes the cleavage of the pro-apoptotic BH3-only protein Bid into its truncated form, tBid. ... Shu HB, Halpin DR, Goeddel DV (June 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751- ...
Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results ... "Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ...
... caspase-dependent cell death, p53 dependent apoptosis, cell proliferation and autophagy as well as hypoxia, although there are ... "A genome-wide RNAi screen reveals multiple regulators of caspase activation". The Journal of Cell Biology. 179 (4): 619-26. doi ... 35 (10): 2244-53. doi:10.1093/carcin/bgu132. PMID 24925029. Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC (6 November 2009). " ... 7 (10): 3713-22. PMC 368027 . PMID 3316986. Rope AF, Wang K, Evjenth R, Xing J, Johnston JJ, Swensen JJ, Johnson WE, Moore B, ...
Caspase-independent apoptosis. The characterization of the caspases allowed the development of caspase inhibitors, which ... Caspases Caspases play the central role in the transduction of ER apoptotic signals. Caspases are proteins that are highly ... The apoptosome cleaves the pro-caspase to its active form of caspase-9, which in turn activates the effector caspase-3. ... There are two types of caspases: initiator caspases, caspase 2,8,9,10,11,12, and effector caspases, caspase 3,6,7. The ...
망막색소상피세포 - 위키백과, 우리 모두의 백과사전
Martinon F, Burns K, Tschopp J (2002). "The inflammasome: a molecular platform triggering activation of inflammatory caspases ... first 10=. (도움말); 지원되지 않는 변수 무시됨: ,last 13=. (도움말); 지원되지 않는 변수 무시됨: ,first 12=. (도움말); 지원되지 않는 변수 무시됨: ,first 15=. (도움말); 지원되지 ... last 10=. (도움말); 지원되지 않는 변수 무시됨: ,first 11=. (도움말) *↑ Ferrari S, Di Iorio E, Barbaro V, Ponzin D, Sorrentino FS, Parmeggiani F ... "DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration". 》PNAS》 111 (45): 16082 ...
Similar to other caspases, caspase-1 starts off as an inactive precursor called zymogen. The caspase-1 enzymes become activated ... ASC contains a caspase activation and recruitment domain (CARD) that binds and facilitates activation of pro-caspase-1 through ... In contrast to apoptosis, pyroptosis requires the function of the enzyme caspase-1. Caspase-1 is activated during pyroptosis by ... Caspase-1 was known as an interleukin-1β converting enzyme, as it was first discovered in association with the cleavage of pro- ...
... and executioner caspases 3 and 7 which trigger apoptosis. Caspase 7 is the most sensitive to granzyme B and caspases 3, 8, and ... The caspase independent pathways of cell death are thought to have arisen to overcome viruses that can inhibit caspases and ... Once inside the target cell granzyme B can cleave and activate initiator caspases 8 and 10, ... into a 50 kDa fragment and then into an additional 60 kDa indirectly through the caspases it activates. Granzyme B can degrade ...
Paracaspase has been shown to have proteolytic activity through its caspase-like domain in T lymphocytes. Cysteine 464 and ... two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell. 6 (4): 961-7. doi: ... two central immunoglobulin-like domains involved in the binding to the B-cell lymphoma 10 (Bcl10) protein and a caspase-like ...
Early 35 kDa protein
P35 has been shown to be a caspase inhibitor with a very wide spectrum of activity both in regard to inhibited caspase types ... However, unlike other caspase substrate proteins, the fragments of P35 do not dissociate from the caspase after cleavage. ... "Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35". Journal of ... The mechanism of caspase inhibition was discovered by Guozhou Xu in the team of Hao Wu at the Department of Biochemistry at ...
TNF-related apoptosis-inducing ligand TRAIL activates Caspase 3 (CASP3), which in turn interacts with caspases 6, 7, 8, 9, and ... doi:10.1016/S1472-6483(10)61304-1. PMID 16102296. Manabe N, Matsuda-Minehata F, Goto Y, et al. (July 2008). "Role of cell death ... 10 to induce apoptosis in granulosa cells. In addition, two intracellular inhibitor proteins, cellular FLICE-like inhibitory ...
In one such pathway, caspase-independent apoptosis, the E3 ligase C-terminal of Hsc-70 interacting protein (CHIP), a regulator ... Lemarié A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L (Jun 2004). "Cadmium induces caspase-independent ... This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the ... Differential involvement of caspase-3 and endonuclease G". Journal of Neurovirology. 10 (3): 141-51. doi:10.1080/ ...
... of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase ... 4 (10): 1177-81. doi:10.1038/2673. PMID 9771752.. *^ Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, ... 10: 373-403. doi:10.1146/annurev.cb.10.110194.002105. PMID 7888181.. *^ Laudon H, Hansson EM, Melén K, Bergman A, Farmery MR, ... 10 (3): 563-8. doi:10.1097/00001756-199902250-00022. PMID 10208590.. *^ Zhang W, Han SW, McKeel DW, Goate A, Wu JY (February ...
Executioner Caspases (Caspase 3, Caspase 6 and Caspase 7). Once initiator caspases are activated, they produce a chain reaction ... Caspase-1, Caspase-4, Caspase-5 and Caspase-11 are considered 'Inflammatory Caspases'. ... Caspase-1, Caspase-4 and Caspase-5 in humans, and Caspase-1 and Caspase-11 in mice play important roles in inducing cell death ... or direct activation of Executioner Caspases (Caspase 3, Caspase 6 and Caspase 7) to degrade cellular components as shown in ...
Classzone Use this site to review the basics of this unit. Choose high school science, Kentucky and the green biology book for Kentucky. Although this site does not review all of the required information it does cover much of the basic information. ...
Mouse anti Human caspase-14, clone 4C9 recognizes human caspase-14, a 242 amino acid ~28 kDa non-apoptotic caspase which exists as a
Complete information for CASP5 gene (Protein Coding), Caspase 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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AID 513048 - Inhibition of human caspase-3-mediated apoptosis assessed as Ac-DEVD-7-amino-4-methylcoumarin cleavage product at...
BioAssay record AID 513048 submitted by ChEMBL: Inhibition of human caspase-3-mediated apoptosis assessed as Ac-DEVD-7-amino-4-methylcoumarin cleavage product at 100 uM by fluorescence assay.
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Autoimmune Lymphoproliferative Syndrome Clinical Presentation: History, Physical Examination, Complications
Autoimmune lymphoproliferative syndrome (ALPS) is characterized by nonmalignant lymphadenopathy, splenomegaly, and autoimmune cytopenias. In 1995, defective lymphocyte apoptosis secondary to mutations in the FAS gene was identified as a molecular basis for ALPS.
The purpose of the protocol is to allow for patients, and relatives of patients, who may have the newly described autoimmune lymphoproliferative syndrome, to be evaluated at the NIH Clinical Center. This evaluation will include blood and relevant tissue studies along with long-term clinical evaluations to define the biology, inheritance,clinical spectrum, and natural history of this syndrome. The aim of the research is to understand mechanisms involved in the development of expanded numbers of what is typically a rare population of immune cells (CD4-8-/TCRalpha/beta+ T cells, otherwise referred to as double negative T cells), and how these relate to the development of expanded numbers of immune cells and autoimmune (self against self) responses in patients with ALPS.. In some cases, we may proivide treatment related to ALPS. These treatments are consistent with standard medical practice.. Participants with ALPS will be invited to visit the NIH once a year or more frequently when clinically ...
Langan RC, Gill F, Raiji MT, Mullinax JE, Pittaluga S, Pandalai P, Davis J, Perkins K, Avital I, Rudloff U. Autoimmune pancreatitis in the autoimmune lymphoproliferative syndrome (ALPS): a sheep in wolves clothing? Pancreas. 2013 Mar; 42(2):363-6 ...
A fundamental biological question that remains largely unresolved concerns the mechanism by which binding of ligands to receptors on the cell surface causes transmission of a signal through the plasma membrane. One appealing explanation has been that ligand binding brings receptors together into multimeric complexes. Three reports describe cases in which the opposite approach is taken, and the receptors are bound and lie in wait for the ligand. Siegel et al. and Chan et al. have examined how the Fas and tumor necrosis factor (TNF) receptors signal. They define a protein interaction domain in these receptors that mediates assembly of the receptors into complexes in the absence of ligand. Such association is shown to be necessary for ligand binding and subsequent signaling. The results also explain how abnormal forms of Fas can dominantly prevent Fas-induced signaling in the human disease known as autoimmune lymphoproliferative syndrome. When bound to their cognate receptors, interferons (IFNs) ...
Programmed Death Ligand-1 (PD-L1) Expression in the Programmed Death Receptor-1 (PD-1)/PD-L1 Blockade: A Key Player Against...
Free Online Library: Programmed Death Ligand-1 (PD-L1) Expression in the Programmed Death Receptor-1 (PD-1)/PD-L1 Blockade: A Key Player Against Various Cancers.(Report) by Archives of Pathology & Laboratory Medicine; Health, general Apoptosis Research Gene expression
Treatment is most commonly directed at autoimmune disease and may be needed to treat bulky lymphoproliferation. First line therapies include corticosteroids (very active but toxic with chronic use), and IVIgG, which are not as effective as in other immune cytopenia syndromes. Second line therapies include: mycophenolate mofetil (cellcept) which inactivates inosine monophosphate, most studied in clinical trials with responses varying (relapse, resolution, partial response). It does not affect lymphoproliferation or reduce DNTs, with no drug-drug interactions. This treatment is commonly used agent in patients who require chronic treatment based on tolerance and efficacy. It may cause hypogammaglobulinemia (transient) requiring IVIgG replacement. Sirolimus (rapamycin, rapamune) which is a mTOR (mammalian target of rapamycin) inhibitor can be active in most patients and can in some cases lead to complete or near-complete resolution of autoimmune disease (,90%) With this treatment ...
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Covered on Genetics Home Reference: autoimmune lymphoproliferative syndromebreast cancerFrom NCBI Gene: Caspase-8 deficiencyHepatocellular carcinomaFamilial cancer of breastLung cancerFrom UniProt: Caspase-8 deficiency (CASP8D): Disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization. [MIM:607271] From NCBI Gene: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of ...
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B. The Proteolysis Map Caspase GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017 "Human PubMed ...
Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome - Tabular View - ClinicalTrials.gov
This study will evaluate the safety and effectiveness of an antibiotic called Fansidar on autoimmune lymphoproliferative syndrome (ALPS). Patients with ALPS have enlarged lymph glands, spleen and/or liver, abnormal blood cell counts and overactive immune function. Current treatments are aimed at suppressing the immune system and improving symptoms, such as anemia (low red blood cell count) and low white blood cell and platelet counts. These treatments, however, are only partially effective and may have complications. Fansidar is a combination of two drugs, sulfadoxine and pyrimethamine, that is used to treat or prevent parasitic infections such as malaria. Recently a child with ALPS who was treated with Fansidar for a different illness had a marked shrinkage of the lymph organs. This study will examine whether Fansidar can shrink the lymph glands or spleen in patients with ALPS.. Patients with ALPS between the ages of 4 and 70 years who have had lymph gland enlargement for at least 1 year and ...
Teachey DT, Manno CS, Axsom KM, et al: Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS). Blood 2005;105:2443-2448. Bader-Meunier B, Rieux-Laucat F, Croisille L, et al: Dyserythropoiesis associated with a fasdeficient condition in childhood. Br J Haematol 2000;108:300-304. Pensati L, Costanzo A, Ianni A, et al: Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis. Gastroenterology 1997;113: 1384-1389. Cell 1997;89:1067-1076. Stanger B, Leder P, Lee T, Kim E, Seed B: RIP: A novel protein containing a death domain that interacts with fas/APO-1(CD95) in yeast and causes cell death. Cell 1995;81:513-523. Chu K, Niu X, Williams LT: A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci USA 1995;92:11894-11898. Barnhart BC, Alappat EC, Peter ME: The CD95 type I/type II model. Semin Immunol 2003;15: 185-193. Siegel RM, Muppidi JR, Sarker M, ...
Human caspase 2 ELISA kit can be used for detecting in vitro quantitative levels of caspase-2 (CASP2) in human serum, cell culture supernatant, plasma, tissue
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Expression of CASP8 (Casp-8, FLICE, MACH, MCH5) in soft tissue 2 tissue. Antibody staining with HPA001302, HPA005688 and CAB002047 in immunohistochemistry.
zVAD-fmk does not totally abrogate FasL-triggered apoptosis in HeLa cells expressing caspase-10 at low level.A, B, Casp10+ and Casp10- HeLa cells were incubated
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Summary of CASP7 (CMH-1, ICE-LAP3, MCH3) expression in human tissue. General cytoplasmic with additional nuclear expression, most abundant in gastrointestinal tract.
This synthetic peptide sequence is selected from human CASP3 construct and is used as the immunogen for PAB2069. (P2577) - Products - Abnova
09:39, 30 April 2015 Homo sapiens:Apoptosis Modulation and Signaling (Corrected ID for AIFM1,CASP4,CASP2,CASP1,HSPA1A,PIDD,TP53,PRKD1,NAIP,XIAP,AIFM2,RIPK1 and PEA15 genes) ...
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease | Haematologica
Although ALPS is frequently caused by mutations in known genes, such as FAS, FASLG or CASP10, in 20-30% of cases the defect is still unknown. It is highly likely that defects in or overexpression of regulators of these genes such as miR-146a22 could result in an ALPS-like phenotype and account for a not yet defined percentage of ALPS-U cases. In the present study we identified an IL12RB1 mutation and the IL12 signaling pathway as such an alternative cause of an ALPS-like phenotype through regulation of FasL expression. Previously it was shown that activation of T and NK cells by IL12 results in upregulation of FasL.23-26,28,42 For instance, Yu et al. showed that dendritic cell-derived IL12 is involved in upregulation of FasL on NK cells leading to cell death.25 Moreover, in the absence of antigen, IL12 induces apoptosis of T cells via upregulation of FasL which can be blocked by anti-FasL antibodies.26 In line with this, we found that primary human T cells deficient in FasL expression were ...
Complete information for CASP8AP2 gene (Protein Coding), Caspase 8 Associated Protein 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Antho 50 induces caspase 3 activation and UHRF1 down-regulation independently of p53 and p73.B CLL cells were incubated with Antho 50 at 75 μg/mL for the ind
Autoimmune Lymphoproliferative Syndrome Clinical Presentation: History, Physical Examination, Complications
Mutations have been identified in each of the genes coding for Fas, Fas-ligand (FasL), caspase-8, and caspase-10. This figure ... Caspase-8 deficiency state (CEDS). Autosomal recessive/ LOF mutation in CASP8 gene (2q33.1). Recurrent sinopulmonary infections ... Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 2002 Sep 26 ... Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) ...https://emedicine.medscape.com/article/1663330-clinical
Caspase 10 - Wikipedia
Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene ... Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B. The Proteolysis Map Caspase GRCh38: Ensembl release 89: ENSG00000003400 ... Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. This gene encodes a protein that is a member of the ...https://en.wikipedia.org/wiki/Caspase_10
Caspase-10 - Wikipedia
... as are caspase-2 (EC 220.127.116.11), caspase-8 (EC 18.104.22.168) and caspase-9 (EC 22.214.171.124). Chang, H.Y.; Yang, X. (2000). " ... Shikama, Y.; Yamada, M.; Miyashita, T. (2003). "Caspase-8 and caspase-10 activate NF-κB through RIP, NIK and IKKα kinases". Eur ... Fischer, U.; Stroh, C.; Schulze-Osthoff, K. (2006). "Unique and overlapping substrate specificities of caspase-8 and caspase-10 ... Caspase-10 (EC 126.96.36.199, FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death ...https://en.wikipedia.org/wiki/Caspase-10
CASP10 - Caspase-10 precursor - Homo sapiens (Human) - CASP10 gene & protein
Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-,-AMC and ... Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors ... PS01122 CASPASE_CYS, 1 hit. PS01121 CASPASE_HIS, 1 hit. PS50207 CASPASE_P10, 1 hit. PS50208 CASPASE_P20, 1 hit. PS50168 ... PS01122 CASPASE_CYS, 1 hit. PS01121 CASPASE_HIS, 1 hit. PS50207 CASPASE_P10, 1 hit. PS50208 CASPASE_P20, 1 hit. PS50168 ...https://www.uniprot.org/uniprot/Q92851
Caspase-10 | definition of caspase-10 by Medical dictionary
What is caspase-10? Meaning of caspase-10 medical term. What does caspase-10 mean? ... Looking for online definition of caspase-10 in the Medical Dictionary? caspase-10 explanation free. ... that activates the caspase-8 or caspase-10 initiator, and subsequently, the caspases effectors -3, -7 and possibly -6.. ... following the activation of caspase initiator caspase-10 and effector caspase-7.. Taiwanin A inhibits MCF-7 cancer cell ...https://medical-dictionary.thefreedictionary.com/caspase-10
Anti-Caspase-9 antibody [10-1-87] (ab115792) | Abcam
Mouse monoclonal Caspase-9 antibody [10-1-87] validated for WB and tested in Human. Immunogen corresponding to recombinant full ... Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically ... Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be ... All lanes : Anti-Caspase-9 antibody [10-1-87] (ab115792) at 1 µg/ml. Lane 1 : Jurkat cell lysate. Lane 2 : Jurkat cell lysate, ...http://www.abcam.com/caspase-9-antibody-10-1-87-ab115792.html
caspase recruitment domain family member 10 ELISA Kits | Biocompare.com
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BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.https://www.biovision.com/products/apoptosis-related-products/caspases/caspase-10/caspase-10-inhibitors.html
CARD10 (caspase recruitment domain family, member 10)
... caspase recruitment domain family, member 10), Authors: Gamze Ayaz, Mesut Muyan. Published in: Atlas Genet Cytogenet Oncol ... The structural domains of CARD10 protein are shown in different color boxes. CARD, caspase-recruitment domain; PDZ, PSD95, DLGA ... Caspase recruitment domain family, member 10, CARD10 (also known as CARMA3 or Bimp1), is a member of the membrane-associated ... CARD10 (caspase recruitment domain family, member 10). Written. 2014-08. Gamze Ayaz, Mesut Muyan. ...http://atlasgeneticsoncology.org/Genes/CARD10ID43187ch22q13.html
caspase-10 Inhibitors | SCBT - Santa Cruz Biotechnology
These inhibit caspase-10 and may affect a variety of other apoptosis and tumor related proteins. ... Caspase-3 Inhibitor I, Cell Permeable An inhibitor of caspase-3, caspase-6, caspase-7, caspase-8, and caspase-10 sc-3074 1 mg. ... Caspase-3 Inhibitor An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10 210344-95-9. sc-3075 0.5 mg. $100.00 30 ... An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10 210344-95-9. sc-311558 sc-311558A 1 mg. 5 mg. $228.00 $970.00 ...https://www.scbt.com/scbt/browse/caspase-10-Inhibitors/_/N-youecm
Caspase-10 Assay Kits
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anti-Caspase 10 antibody | GeneTex
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CASP10 / Caspase 10 - LSBio
... caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases ... This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene ... CASP10 / Caspase 10. caspase 10, apoptosis-related cysteine peptidase. CASP10 / Caspase 10 is a protein which is a member of ... CASP10, ALPS2, Caspase-10, Caspase 10, CASP-10, FADD-like ICE2, FLICE2, MCH4, ICE-like apoptotic protease 4, Apoptotic protease ...https://www.lsbio.com/targets/casp10-caspase-10/g870
Caspase-10 Assay Kit (Colorimetric) - (KA0730) - Products - Abnova
... is used for detecting the activity of caspases that recognize the sequence AEVD using colorimetric method. (KA0730) - Products ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene ... Caspase-10 Assay Kit (Colorimetric) is used for detecting the activity of caspases that recognize the sequence AEVD using ...http://www.abnova.com/products/products_detail.asp?catalog_id=KA0730
Research tested and proven Caspase-10/b-Flice 2 antibody. Antibody is guaranteed to work in western blot applications and is ... frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4 ... caspase-3, -6, and -7).. Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of ... Caspase 10/b Immunoblotting of SDS-extracts from 2 x 105 human Jurkat cells. Extracts were electrophoresed on 20% gels and ...https://www.neuromics.com/RA15047
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Genetic polymorphisms of caspase 8 and 10 genes and risk of non hodgkin s lymphoma for Mona Hazem Elnagdy Saleh
Genetic polymorphisms of caspase 8 and 10 genes and risk of non hodgkin s lymphoma for Mona Hazem Elnagdy Saleh ... Genetic polymorphisms of caspase 8 and 10 genes and risk of non hodgkin s lymphoma for Mona Hazem Elnagdy Saleh * ... Genetic polymorphisms of caspase 8 and 10 genes and risk of non hodgkin s lymphoma for Mona Hazem Elnagdy Saleh. Author(S). ... Genetic polymorphisms of caspase 8 and 10 genes and risk of non hodgkin s lymphoma for Mona Hazem Elnagdy Saleh ...http://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/141890-engb-141890
Caspase-10 Inhibitor Drug Screening Kit (Fluorometric) Kit-2327 - Creative BioMart
Caspase-10 Inhibitor Drug Screening Kit (Fluorometric) can be used for research. ... Purified Caspase-10 Inhibitor Drug Screening Kit (Fluorometric) from Creative Biomart. ... 2X Reaction Buffer; Caspase Substrate AEVD-AFC (1 mM); DTT (1 M); Active Caspase-10 (Lyophilized); Caspase Inhibitor, Z-VAD-FMK ... Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts. The Caspase-10 Inhibitor ...https://www.creativebiomart.net/caspase-10-inhibitor-drug-screening-kit-fluorometric-501048.htm
The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells - Semantic Scholar
Flunarizine-induced DNA fragmentation was inhibited by the caspase-3 inhibitor z-DEVD-fmk, the caspase-8/caspase-10 inhibitor z ... but was not reduced in caspase-8-deficient Jurkat cells, indicating the involvement of caspase-10 upstream of caspase-3 ... Treatment of Jurkat cells with flunarizine resulted in caspase-3 activation, poly (ADP-ribose) polymerase cleavage, and ... and caspase-9 activation, although none of these events were necessary for apoptosis induction. Collectively, these findings ...https://www.semanticscholar.org/paper/The-Ca2%2B-channel-blocker-flunarizine-induces-in-Conrad-Furlong/69c943bb30f67303a617e83b537ede2040e725cd
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... biovis-caspase-10-inhibitor-aevd , Biovis \ Caspase-10 Inhibitor AEVD-FMK \ 1112-20C for more molecular products just contact ... Caspase-8 subunit p10]. [csp-1 Y48E1B.13] Caspase A (EC 188.8.131.52) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14] ... Caspase-3 subunit p12]. [CASP3] Caspase-3 (CASP-3) (EC 184.108.40.206) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] ... Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 ...https://www.antibody-antibodies.com/product1772503/biovis-caspase-10-inhibitor-aevd-fmk.html
Gentaur Molecular :Biovis \ Caspase 10 b, human recombinant \ 1090B-25
... biovis-caspase-10-b-human , Biovis \ Caspase_10_b, human recombinant \ 1090B-25 for more molecular products just contact us ... Caspase-10b (also known as FLICE 2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase ... Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 ... Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 ...https://www.antibody-antibodies.com/product374846/biovis-caspase-10-b-human-recombinant.html
Gentaur Molecular :Biovis \ Caspase-10 Inhibitor AEVD-FMK ; Appearance Liquid \ 1112-20C
Caspase-10 Inhibitor AEVD-FMK ; Appearance Liquid \ 1112-20C for more molecular products just contact us ... 15301743] Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway..  Involvement of caspase-10 in ... 1112-20C Caspase-10 Inhibitor AEVD-FMK ; Appearance Liquid Ask technical file . ... We recommend using 1000X dilutions for inhibiting caspase-10 and related caspase activity (e.g., Add 1 μl to 1 ml of culture ...http://antibody-antibodies.com/product1988522-search-Caspase_10%20Inhibitor%20AEVD_FMK%20
Anti-Caspase-10 抗体 (ab27525) | アブカム
"ウサギ・ポリクローナル抗体 ab27525 交差種: Hu 適用: IHC-P…Caspase-10抗体一覧…画像、プロトコール、文献などWeb上の情報 ... Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-. -AMC and ... Synthetic peptide within Human Caspase-10 aa 450 to the C-terminus (N terminal). The exact sequence is proprietary.. Database ... Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- andhttps://www.abcam.co.jp/Caspase-10-antibody-ab27525.html
Autoimmune diseasesInitiator caspaseCASP10InhibitorsSubstrate AEVD-AFCFluorometricMch4Related caspase activityActivatesMember 10Apoptosis executionProteasesAntibodiesCleavageProcaspase-10ResiduesSubunitsSubstratesEffectorBufferSynthetic peptideCell differentiationRecombinantTriggersAspartateHumanEnzymeCellularProductsFamilyActivitySignals
- This enzyme catalyses the following chemical reaction Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly Caspase-10 is an initiator caspase, as are caspase-2 (EC 220.127.116.11), caspase-8 (EC 18.104.22.168) and caspase-9 (EC 22.214.171.124). (wikipedia.org)
- Together with caspase-10 it belongs to the so-called initiator caspase group, and is important effector activation competent. (thefreedictionary.com)
- FasL expression was up-regulated by taiwanin A at both the transcriptional and translational levels, following the activation of caspase initiator caspase-10 and effector caspase-7. (thefreedictionary.com)
- Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. (wikipedia.org)
- CASP10 is an initiator-type caspase which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein-protein interaction domains. (thefreedictionary.com)
- CASP10 / Caspase 10 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. (lsbio.com)
- Santa Cruz Biotechnology now offers a broad range of caspase-10 Inhibitors. (scbt.com)
- Caspase-10 Inhibitors offered by Santa Cruz inhibit caspase-10 and, in some cases, other apoptosis and tumor related proteins. (scbt.com)
- Cell-permeable and irreversible peptide inhibitors are also available for different caspases. (neuromics.com)
- The Caspase-10 Inhibitor Drug Screening Kit provides an effective means for screening caspase inhibitors using fluorometric methods. (creativebiomart.net)
- Compounds to be screened can directly be added to the reaction and the level of inhibition of caspase-10 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors. (creativebiomart.net)
- Effective means for screening caspase inhibitors using fluorometric methods. (creativebiomart.net)
- Inhibition of caspase-10 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors. (creativebiomart.net)
- Active caspase10/b is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays. (antibody-antibodies.com)
- It cleaves and activates caspase-3, -4, -6, -7, -8 and -9, is recruited to Fas- and TNFR-1 receptors in a FADD-dependent manner, and may participate in the granzyme B apoptotic pathways. (thefreedictionary.com)
- In the extrinsic way, the apoptotic signal begins by the union of extra cellular ligands to the surface of cell receptors, resulting in a recruitment of the cytosolic adapter of proteins, that activates the caspase-8 or caspase-10 initiator, and subsequently, the caspases effectors -3, -7 and possibly -6. (thefreedictionary.com)
- Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. (abcam.com)
- Your search returned 13 caspase recruitment domain family member 10 ELISA ELISA Kit across 1 supplier. (biocompare.com)
- Caspase recruitment domain family, member 10, CARD10 (also known as CARMA3 or Bimp1), is a member of the membrane-associated guanylate kinase (MAGUK) superfamily proteins that act to organize signaling at the plasma membrane. (atlasgeneticsoncology.org)
- Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. (semanticscholar.org)
- Activation involves dimerization and often oligomerisation of pro-caspases, followed by cleavage into a small subunit and large subunit. (wikipedia.org)
- CAD release from ICAD inhibition is achieved by cleavage of ICAD at these Asp residues by the caspase-3. (wikipedia.org)
- During apoptosis procaspase-10 is processed at aspartate residues to form active caspase-10 which consists of two large (18 kDa) and two small (11 kDa) subunits in a heterotetramer form. (antibody-antibodies.com)
- FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC). (rug.nl)
- Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. (wikipedia.org)
- DFFA is encoded by an alternatively encrypted mRNAs originating two distinct forms: short (ICAD-S) and long (ICAD-L), which act like a specific chaperone ensuring the correct CAD's folding Besides, it contains two aspartic acid residues (Asp117 and Asp224) where CAD is identified and, consequently, it stays bounded until Caspase-3 splits this union. (wikipedia.org)
- Please read carefully the data sheet of the Caspase_10_b, human recombinant. (antibody-antibodies.com)
- Caspase_10_b, human recombinant Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
- One unit of the recombinant caspase-10/b is the enzyme activity that cleaves 1 nmol of the caspase substrate IETD-pNA (pNA: pnitroanaline) per hour at 37°C in a reaction solution containing 50 mM Hepes, pH 7.2, 50 mM NaCl, 0.1% Chaps, 10 mM EDTA, 5% Glycerol, and 10 mM DTT. (antibody-antibodies.com)
- The recombinant active human caspase-10/b was expressed in E. coli. (antibody-antibodies.com)
- Caspase 10/b Immunoblotting of SDS-extracts from 2 x 105 human Jurkat cells. (neuromics.com)
- The tertiary structure of the domain has been described from the crystallization of caspase 8 in the human. (rug.nl)
- Structure of caspase-1 (CASP1), originally called interleukin-1 beta-converting enzyme (ICE), the first human caspase to be identified. (wikipedia.org)
- The lyophilized caspase-10/b is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease. (antibody-antibodies.com)
- The active enzyme often exists as a heterotetramer in the biological environment, where a pro-caspase dimer is cleaved together to form a heterotetramer. (wikipedia.org)
- Caspase-10 Assay Kit (Colorimetric) is used for detecting the activity of caspases that recognize the sequence AEVD using colorimetric method. (abnova.com)
- 8. Fold-increase in AEVD-dependent caspase activity can be determined by comparing these results with the level of the uninduced control. (antibody-antibodies.com)
- We recommend using 1 unit/assay for analyzing caspase activity. (antibody-antibodies.com)