Casein kinase iepsilon. Medical search

A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM.

A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.

A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING.

Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.

A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.

A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.

A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.

A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.

A casein kinase I isoenzyme that plays a regulatory role in a variety of cellular functions including vesicular transport, CHROMOSOME SEGREGATION; CYTOKINESIS, developmental processes, and the CIRCADIAN RHYTHM.

A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.

The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.

An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate. EC 5.4.2.1.

A belief or practice which lacks adequate basis for proof; an embodiment of fear of the unknown, magic, and ignorance.

A tube of ectodermal tissue in an embryo that will give rise to the CENTRAL NERVOUS SYSTEM, including the SPINAL CORD and the BRAIN. Lumen within the neural tube is called neural canal which gives rise to the central canal of the spinal cord and the ventricles of the brain. For malformation of the neural tube, see NEURAL TUBE DEFECTS.

Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.

The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.

The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.

Flies of the species Musca domestica (family MUSCIDAE), which infest human habitations throughout the world and often act as carriers of pathogenic organisms.

The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.

Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.

An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, SARCOPHAGIDAE, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).

The class Insecta, in the phylum ARTHROPODA, whose members are characterized by division into three parts: head, thorax, and abdomen. They are the dominant group of animals on earth; several hundred thousand different kinds having been described. Three orders, HEMIPTERA; DIPTERA; and SIPHONAPTERA; are of medical interest in that they cause disease in humans and animals. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p1)

Disciplines that apply sciences to law. Forensic sciences include a wide range of disciplines, such as FORENSIC TOXICOLOGY; FORENSIC ANTHROPOLOGY; FORENSIC MEDICINE; FORENSIC DENTISTRY; and others.

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.

Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.

Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.

A species of fruit fly much used in genetics because of the large size of its chromosomes.

The observable response an animal makes to any situation.

A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.

A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.

The absence of light.

A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.

A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.

Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.

The teaching staff and members of the administrative staff having academic rank in an educational institution.

Individuals enrolled in a school or formal educational program.

Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.

A genus of the family REOVIRIDAE infecting vertebrates only. Transmission is horizontal and infected species include humans, birds, cattle, monkeys, sheep, swine, baboons, and bats. MAMMALIAN ORTHOREOVIRUS is the type species.

A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

A species of nematode that is widely used in biological, biochemical, and genetic studies.

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

A notch receptor that plays an important role in CELL DIFFERENTIATION in a variety of cell types. It is the preferentially expressed notch receptor in mature B-LYMPHOCYTES.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

A notch receptor that interacts with a variety of ligands and regulates SIGNAL TRANSDUCTION PATHWAYS for multiple cellular processes. It is widely expressed during EMBRYOGENESIS and is essential for EMBRYONIC DEVELOPMENT.

A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.

Requirement of circadian genes for cocaine sensitization in Drosophila. (1/96)

The circadian clock consists of a feedback loop in which clock genes are rhythmically expressed, giving rise to cycling levels of RNA and proteins. Four of the five circadian genes identified to date influence responsiveness to freebase cocaine in the fruit fly, Drosophila melanogaster. Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for period, clock, cycle, and doubletime, but not in flies lacking the gene timeless. Flies that do not sensitize owing to lack of these genes do not show the induction of tyrosine decarboxylase normally seen after cocaine exposure. These findings indicate unexpected roles for these genes in regulating cocaine sensitization and indicate that they function as regulators of tyrosine decarboxylase. (+info)

double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. (2/96)

We have isolated the discs overgrown gene of Drosophila and shown that it encodes a homolog of the Casein kinase I(delta)/(epsilon) subfamily and is identical to the double-time gene. However, in contrast to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal discs. Analysis of their phenotypes and molecular lesions suggests that the Discs overgrown protein is a crucial component in the mechanism that links cell survival during proliferation to growth arrest in imaginal discs. This work provides the first analysis in a multicellular organism of Casein kinase I(delta)/(epsilon) functions necessary for survival. Since the amino acid sequences and three-dimensional structures of Casein kinase I(delta)/(epsilon) enzymes are highly conserved, the results suggest that these proteins may also function in controlling cell growth and survival in other organisms. (+info)

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. (3/96)

Phosphorylation is an important feature of pacemaker organization in Drosophila. Genetic and biochemical evidence suggests involvement of the casein kinase I homolog doubletime (dbt) in the Drosophila circadian pacemaker. We have characterized two novel dbt mutants. Both cause a lengthening of behavioral period and profoundly alter period (per) and timeless (tim) transcript and protein profiles. The PER profile shows a major difference from the wild-type program only during the morning hours, consistent with a prominent role for DBT during the PER monomer degradation phase. The transcript profiles are delayed, but there is little effect on the protein accumulation profiles, resulting in the elimination of the characteristic lag between the mRNA and protein profiles. These results and others indicate that light and post-transcriptional regulation play major roles in defining the temporal properties of the protein curves and suggest that this lag is unnecessary for the feedback regulation of per and tim protein on per and tim transcription. (+info)

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. (4/96)

Circadian (24 hour) PERIOD (PER) protein oscillation is dependent on the double-time (dbt) gene, a casein kinase Ivarepsilon homolog [1-3]. Without dbt activity, hypophosphorylated PER proteins over-accumulate, indicating that dbt is required for PER phosphorylation and turnover [3,4]. There is evidence of a similar role for casein kinase Ivarepsilon in the mammalian circadian clock [5,6]. We have isolated a new dbt allele, dbt(ar), which causes arrhythmic locomotor activity in homozygous viable adults, as well as molecular arrhythmicity, with constitutively high levels of PER proteins, and low levels of TIMELESS (TIM) proteins. Short-period mutations of per, but not of tim, restore rhythmicity to dbt(ar) flies. This suppression is accompanied by a restoration of PER protein oscillations. Our results suggest that short-period per mutations, and mutations of dbt, affect the same molecular step that controls nuclear PER turnover. We conclude that, in wild-type flies, the previously defined PER'short domain' [7,8] may regulate the activity of DBT on PER. (+info)

Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. (5/96)

The clock gene double-time (dbt) encodes an ortholog of casein kinase Iepsilon that promotes phosphorylation and turnover of the PERIOD protein. Whereas the period (per), timeless (tim), and dClock (dClk) genes of Drosophila each contribute cycling mRNA and protein to a circadian clock, dbt RNA and DBT protein are constitutively expressed. Robust circadian changes in DBT subcellular localization are nevertheless observed in clock-containing cells of the fly head. These localization rhythms accompany formation of protein complexes that include PER, TIM, and DBT, and reflect periodic redistribution between the nucleus and the cytoplasm. Nuclear phosphorylation of PER is strongly enhanced when TIM is removed from PER/TIM/DBT complexes. The varying associations of PER, DBT and TIM appear to determine the onset and duration of nuclear PER function within the Drosophila clock. (+info)

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. (6/96)

The Drosophila double-time (dbt) gene, which encodes a protein similar to vertebrate epsilon and delta isoforms of casein kinase I, is essential for circadian rhythmicity because it regulates the phosphorylation and stability of period (per) protein. Here, the circadian phenotype of a short-period dbt mutant allele (dbt(S)) was examined. The circadian period of the dbt(S) locomotor activity rhythm varied little when tested at constant temperatures ranging from 20 to 29 degrees C. However, per(L);dbt(S) flies exhibited a lack of temperature compensation like that of the long-period mutant (per(L)) flies. Light-pulse phase-response curves were obtained for wild-type, the short-period (per(S)), and dbt(S) genotypes. For the per(S) and dbt(S) genotypes, phase changes were larger than those for wild-type flies, the transition period from delays to advances was shorter, and the light-insensitive period was shorter. Immunohistochemical analysis of per protein levels demonstrated that per protein accumulates in photoreceptor nuclei later in dbt(S) than in wild-type and per(S) flies, and that it declines to lower levels in nuclei of dbt(S) flies than in nuclei of wild-type flies. Immunoblot analysis of per protein levels demonstrated that total per protein accumulation in dbt(S) heads is neither delayed nor reduced, whereas RNase protection analysis demonstrated that per mRNA accumulates later and declines sooner in dbt(S) heads than in wild-type heads. These results suggest that dbt can regulate the feedback of per protein on its mRNA by delaying the time at which it is translocated to nuclei and altering the level of nuclear PER during the declining phase of the cycle. (+info)

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. (7/96)

In all genetically studied model organisms, a negative feedback loop of gene expression contributes to the circadian rhythm mechanism. In the Drosophila system, it has been proposed that the delay between the synthesis and function of clock proteins is due to phosphorylation-regulated nuclear entry. To test this hypothesis, we assayed the relationship between PER phosphorylation, nuclear localization, and transcriptional repression activity in cultured S2 cells. The results indicate that the two putative PER kinases DBT and CKII work together to phosphorylate PER and increase repression activity. Experiments combining kinase inhibition with inhibition of PER nuclear export suggest that phosphorylation directly affects PER repression activity and that PER nuclear localization is an indirect consequence of the association of active PER with DNA or chromatin. This interpretation suggests further that the circadian regulation of PER nuclear localization in flies reflects changes in PER transcriptional activity rather than in PER nuclear import or export activity. (+info)

Casein kinase Iepsilon modulates the signaling specificities of dishevelled. (8/96)

Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this pathway by transducing the signal from the Wnt receptor complex to the beta-catenin destruction complex. Dvl also plays a pivotal role in the planar cell polarity pathway that involves the c-Jun N-terminal kinase (JNK). How functions of Dvl are regulated in these two distinct pathways is not clear. We show that deleting the C-terminal two-thirds of Dvl, which includes the PDZ and DEP domains and is essential for Dvl-induced JNK activation, rendered the molecule a much more potent activator of the beta-catenin pathway. We also found that casein kinase Iepsilon (CKIepsilon), a previously identified positive regulator of Wnt signaling, stimulated Dvl activity in the Wnt pathway, but dramatically inhibited Dvl activity in the JNK pathway. Consistent with this, overexpression of CKIepsilon in Drosophila melanogaster stimulated Wnt signaling and disrupted planar cell polarity. We also observed a correlation between the localization and the signaling activity of Dvl in the beta-catenin pathway and the JNK pathway. Furthermore, by using RNA interference, we demonstrate that the Drosophila CKIepsilon homologue Double time positively regulates the beta-catenin pathway through Dvl and negatively regulates the Dvl-induced JNK pathway. We suggest that CKIepsilon functions as a molecular switch to direct Dvl from the JNK pathway to the beta-catenin pathway, possibly by altering the conformation of the C terminus of Dvl. (+info)

"The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon". The Journal of Biological ... Maywood ES, Chesham JE, Smyllie NJ, Hastings MH (April 2014). "The Tau mutation of casein kinase 1ε sets the period of the ... CLOCK/BMAL1 transactivation, is activated by phosphorylation by casein kinase 1ε and inhibited by phosphorylation by MAPK. ... is modulated in the cytoplasm by phosphorylation of PER proteins by casein kinase 1ε or δ (CK1 ε or CK1 δ), targeting these ...

https://en.wikipedia.org/wiki/ARNTL

"The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon". Cell. 94 (1): 97-107 ... Rivers A, Gietzen KF, Vielhaber E, Virshup DM (June 1998). "Regulation of casein kinase I epsilon and casein kinase I delta by ... Casein kinase 1 isoform epsilon Casein kinase 1 family GRCh38: Ensembl release 89: ENSG00000141551 - Ensembl, May 2017 GRCm38: ... "A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of ...

https://en.wikipedia.org/wiki/CSNK1D

August 2002). "The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and ... May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta ... "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent ... Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a ...

https://en.wikipedia.org/wiki/GSK3B

... casein kinase idelta MeSH D08.811.913.696.620.682.700.140.300.300 - casein kinase iepsilon MeSH D08.811.913.696.620.682.700.140 ... map kinase kinase kinase 1 MeSH D08.811.913.696.620.682.700.559.200 - map kinase kinase kinase 2 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 - map kinase kinase kinase 4 MeSH D08.811.913.696.620.682. ... casein kinases MeSH D08.811.913.696.620.682.700.140.300 - casein kinase i MeSH D08.811.913.696.620.682.700.140.300.100 - casein ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

... casein kinase idelta MeSH D12.644.360.150.300.300 - casein kinase iepsilon MeSH D12.644.360.150.600 - casein kinase ii MeSH ... map kinase kinase kinase 1 MeSH D12.644.360.400.200 - map kinase kinase kinase 2 MeSH D12.644.360.400.300 - map kinase kinase ... kinase 3 MeSH D12.644.360.400.400 - map kinase kinase kinase 4 MeSH D12.644.360.400.500 - map kinase kinase kinase 5 MeSH ... casein kinases MeSH D12.644.360.150.300 - casein kinase i MeSH D12.644.360.150.300.100 - casein kinase ialpha MeSH D12.644. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)

"The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon". Cell. 94 (1): 97-107 ... "casein kinase 1 alpha" and "casein kinase 1 epsilon". Casein kinase 1 epsilon has been suggested to play a role in ... Casein kinase 2 - a distinct protein kinase family Eide EJ, Virshup DM (May 2001). "Casein kinase I: another cog in the ... In humans there are three casein kinase 1 gamma enzymes. Xenopus casein kinase 1 gamma (CK1gamma) is associated with the cell ...

https://en.wikipedia.org/wiki/Casein_kinase_1

Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (October 1999). "Casein kinase iepsilon in the wnt pathway: regulation of ... The protein encoded by the casein kinase 1 epsilon gene is a serine/threonine protein kinase and a member of the casein kinase ... Casein kinase 1 epsilon, and related casein kinase 1 delta, is dephosphorylated in this pathway. Dephosphorylation of casein ... The current theory for how casein kinase 1 epsilon and/or casein kinase 1 delta function in this pathway is that both casein ...

https://en.wikipedia.org/wiki/Casein_kinase_1_isoform_epsilon

Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta- ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Selective PF-4800567 Non-selective PF-670462 (also inhibits CK1-δ) Casein kinase 1 isoform epsilon Casein kinase 1 family ... The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose ...

https://en.wikipedia.org/wiki/CSNK1E

The effect of the addition of the camel casein fraction on some physico-chemical properties of low fat camel milk cream was ... Casein Kinase Iepsilon. A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN ... Casein Kinase I. A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kD. ... Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I ...

https://www.bioportfolio.com/resources/pmarticle/2053481/Effect-of-casein-and-inulin-addition-on-physico-chemical-characteristics-of-low.html

2002) The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem 277(19): ... 2000) Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol 20(13): ... Furthermore, identification of kinases (28, 29) and ubiquitin ligases (30, 31) that modulate the activity and stability of the ...

https://www.pnas.org/content/113/41/E6072

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94, 97-107 (1998 ... Pharmacological inhibition of casein kinase 1 (CK1) increases period length in mammalian cell culture3,5,14, rodents5,15 and ... Casein kinase 1delta activity: a key element in the zebrafish circadian timing system. PLoS ONE 8, e54189 (2013). ... Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci USA 107, ...

https://www.nature.com/articles/s41598-019-48914-7?error=cookies_not_supported&code=98b8a824-0b5d-4ccb-bd2e-a70de35500ae

Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. Blood. 2004;103: 2997-3004. ... Casein kinase I ϵ (CKIϵ), a core component of the circadian system, regulates the stability of Per by phosphorylating these ... 32P-ATP by T4 polynucleotide kinase. Nuclear extracts from NIH 3T3 cells either untransfected or transfected with a C/EBPα ...

http://www.bloodjournal.org/content/106/8/2827?ijkey=8b2a850d6158556c29df0bafe263610dc49fd22c&keytype2=tf_ipsecsha&sso-checked=true

https://en.wikipedia.org/wiki/Casein_kinase_1_isoform_epsilon

https://en.wikipedia.org/wiki/Casein_kinase_1

2004a). Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol. Cell. Biol. 24, 2000-2011. doi: ... Casein kinase 2 (CK2), Protein Kinase C (PKC), Hypoxia-induced protein kinase (HIPK), Receptor-interacting protein kinase 4 ( ... and protein kinases such as Casein Kinase 1 (CK1) and Glycogen Synthase Kinase 3β (GSK3β; Niehrs, 2012; Schulte et al., 2010; ... 2001). Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. J. Biol. Chem. 276, 33147-33155. ...

http://dev.biologists.org/content/144/12/2234

1998 The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94: 97-107. ... or indeed other kinases such as casein kinase 2, which have been implicated with PER stability (J. M. Lin et al. 2002; Akten et ... Lin, J. M., V. L. Kilman, K. Keegan, B. Paddock, M. Emery-Le et al., 2002 A role for casein kinase 2α in the Drosophila ... Given PERs intimate association with the DBT kinase, which earmarks it for degradation (Kloss et al. 1998; Price et al. 1998 ...

https://www.genetics.org/content/177/3/1539

The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem. 2002;277(19): ... 80 Lipton et al indicated that hepatic BMAL1 is rhythmically phosphorylated by the mTOR-effector kinase S6K1 and associated ...

https://www.dovepress.com/the--skeletal-muscle-circadian-clock-current-insights-peer-reviewed-fulltext-article-CPT

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell (1998) 94:97-107 ... Casein kinase 1: complexity in the family. Int J Biochem Cell Biol (2011) 43:465-9. doi:10.1016/j.biocel.2010.12.004 ... Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Mol ... A role for casein kinase 2 in the mechanism underlying circadian temperature compensation. Cell (2009) 137:749-60. doi:10.1016/ ...

https://www.frontiersin.org/articles/10.3389/fneur.2017.00161/full

The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J. Biol. Chem. 277:17248- ... Members of the Leishmania casein kinase 1 (CK1) family represent promising therapeutic targets. Leishmania casein kinase 1 ... casein kinase 1 (CK1), a family of multifunctional Ser/Thr protein kinases that are characterized by a highly conserved kinase ... The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal. 17:675-689. doi:10.1016/j. ...

https://aac.asm.org/content/58/3/1501

Cong, F., Schweizer, L. and Varmus, H. (2004a). Casein kinase Iepsilon modulates the signaling specificities of dishevelled. ... Peters, J. M., McKay, R. M., McKay, J. P. and Graff, J. M. (1999). Casein kinase I transduces Wnt signals. Nature 401, 345-350. ... Hino, S., Michiue, T., Asashima, M. and Kikuchi, A. (2003). Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and ... Davidson, G., Wu, W., Shen, J., Bilic, J., Fenger, U., Stannek, P., Glinka, A. and Niehrs, C. (2005). Casein kinase 1g couples ...

http://jcs.biologists.org/content/119/3/395?ijkey=52a62947f4c595a881d932ac81a43f3f28ce184e&keytype2=tf_ipsecsha

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc. Natl. Acad. Sci. USA96:12548-12552. ... Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Curr. Biol.16:1329-1336. ... Casein kinase 1 (CK1) is a serine/threonine kinase that is evolutionarily conserved from yeast to mammals (for a review, see ... and protein kinase Cζ (PKCζ) and casein kinase 2 (CK2) proteins were obtained from Calbiochem. An active form of GSK-3β protein ...

https://mcb.asm.org/content/27/10/3804

1998). The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94, 97-107 ... Kim, E. Y., Ko, H. W., Yu, W., Hardin, P. E., and Edery, I. (2007). A DOUBLETIME kinase binding domain on the Drosophila PERIOD ... PER nuclear entry is controlled by multiple kinases, including CK2 (Helfrich-Forster, 2005; Chiu et al., 2008), SGG (Martinek ... et al., 2001), and probably a still unknown proline-directed kinase (Ko et al., 2010). PER phosphorylation by DBT promotes PER ...

https://www.frontiersin.org/articles/10.3389/fncel.2017.00317/full

1998). The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94, 97-107 ... The period of circadian cycle is also dependent upon the efficiency of a cocktail of kinases, which determine its day-to-day ... precision (Kloss et al., 1998; Price et al., 1998). In the light of the role of kinases involved in the molecular clockwork, it ...

https://jeb.biologists.org/content/215/20/3527

Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. J. Biol. Chem. 276,33147 -33155. ... Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5). ... Also known as cell adhesion kinase beta; focal adhesion kinase 2; protein tyrosine kinase 2 beta, cell adhsion kinase beta, ... Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J. Biol. Chem. 262,14042 - ...

http://jcs.biologists.org/content/116/7/1175?ijkey=aa5e6bf5983d0c651923d106d68885856536fc6a&keytype2=tf_ipsecsha

1999) Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc. Natl. Acad. Sci. USA 96, 12548- ... 1999) Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol 9 ... 1997) Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal ... 1992) c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in ...

https://dev.biologists.org/content/127/14/3141?ijkey=cb2ea148ad555d92de8a2beb6eea93ede230edfb&keytype2=tf_ipsecsha

The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.; PubMed Europe PMC ... In the cytosol the kinases CSNK1D (casein kinase I delta) and CSNK1E (casein kinase I epsilon) phosphorylate PER1, PER2, CRY1, ... CRY:PER:Kinase. Arrow. R-HSA-1856948 (Reactome) CRY:PER:Kinase. R-HSA-400382 (Reactome) CRY:PER:Kinase. mim-catalysis. R-HSA- ... p-CRY:p-PER:Kinase. Arrow. R-HSA-400382 (Reactome) p-CRY:p-PER:Kinase. Arrow. R-HSA-549385 (Reactome) p-CRY:p-PER:Kinase. R-HSA ...

https://www.wikipathways.org/index.php?title=Pathway:WP1797&oldid=101184

Sakanaka, Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. 1999, Pubmed, Xenbase Salic, Control ... Tcf3 is a substrate for both glycogen synthase kinase (GSK) 3 and casein kinase (CK) 1epsilon, and phosphorylation of Tcf3 by ... Peters, Casein kinase I transduces Wnt signals. 1999, Pubmed, Xenbase Playford, Insulin-like growth factor 1 regulates the ... Chijiwa, A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and ...

http://www.xenbase.org/literature/article.do?method=display&articleId=8496

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.. Cell (1998 Jul 10) ... A new role for an old kinase: CK2 and the circadian clock.. Nat Neurosci (2003 Mar) PMID: 12601377. Blau J ... The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.. J Neurosci (2005 ...

https://as.nyu.edu/faculty/justin-blau.html

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell. 1998;94:97-107 ... Maisonpierre P, Barrezueta N, Yancopoulos G. Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family ... Roselli Rehfuss L, Ye F, Lissemore J, Sullivan D. Structure and expression of the phosphoglycerate kinase (Pgk) gene of ... Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet. 2000;24:271- ...

http://www.labome.org/locale/united/experts-and-doctors-on-in-situ-hybridization-in-new-york--united-states-136634.html

The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. Kani, S., Oishi, I., Yamamoto, H ... We show that when expressed in mammalian cells, Ror2 associates with casein kinase Iepsilon (CKIepsilon), a crucial regulator ... We show that Ror2 (tyrosine kinase receptor) and BRI-b (serine/threonine kinase receptor) form a ligand independent heteromeric ... Synonyms: Neurotrophic tyrosine kinase, receptor-related 2, Ntrkr2, Tyrosine-protein kinase transmembrane receptor ROR2, mROR2 ...

https://www.wikigenes.org/e/gene/e/26564.html

Casein kinase Iepsilon colocalizes with dishevelled along actin fibers and in the perinuclear region, whereas axin and GSK-3 ... expression of kinase-inactive protein kinase D and low temperature incubation) cause accumulation of Sec6/8 on the TGN, ... Protein tyrosine kinases are one class of regulatory molecules that have been implicated in the modulation of these processes. ... Several protein tyrosine kinases co-localize with cell-cell (cadherin) and cell-ECM (integrin) adhesion molecules at specific ...

https://med.stanford.edu/profiles/pedrheumatology/w-james-nelson

https://med.stanford.edu/profiles/w-james-nelson

1998 The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94: 97-107. ... B0252.1 is a putative homolog of Cla4, a Cdc42-activated signal transducing kinase of the PAK (p21-activated kinase) family in ... In total, we tested 246 kinase genes and 167 phosphatase genes. All kinase and phosphatase RNAi clones were tested in ... the homologous kinases and phosphatases in Drosophila median neurosecretory cells showed that atypical protein kinase C kinase ...

http://www.g3journal.org/content/4/1/173

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I-epsilon. Cell 94: 97-107, [ ... except for the kinases and phosphatases that are involved in the molecular clockwork [70]. The kinases and phosphatases in ... The PER/CRY protein complex is phosphorylated in the cytoplasm by specific kinases, which then acts as inhibitor for their own ... The heterodimer of PER/TIM is phosphorylated in the cytoplasm in the presence of specific kinases, and the phosphorylated ...

https://www.jcircadianrhythms.com/articles/10.1186/1740-3391-3-7/

Using expression cloning to identify novel components of the Wnt pathway, casein kinase Iepsilon (CKIepsilon) has been ... and several kinases, such as protein kinase C, mitogen-activated protein kinase-activated protein kinase-1 [p90(Rsk)], p70( ... This region harbors several putative casein kinase II (CKII) and glycogen synthase kinase-3ß (GSK-3ß) phosphorylation sites and ... Evidence that glycogen synthase kinase 3ß (GSK-3ß) and extracellular signal-regulated kinase mitogen-activated protein kinase ( ...

http://www.sdbonline.org/sites/fly/segment/shaggy2c.htm

Casein Kinase Iepsilon * Systems Integration * Suprachiasmatic Nucleus Planning an Evaluation of After School Matters. Hirsch, ...

https://www.scholars.northwestern.edu/en/projects/?format=&page=811

Casein Kinase Iepsilon * Systems Integration * Suprachiasmatic Nucleus Consortium for Mouse Genetics of Addition, Project 1. ...

https://www.scholars.northwestern.edu/en/organisations/cscb-center-for-sleep-and-circadian-biology/projects/?status=FINISHED&ordering=title&descending=false

2008 Inhibition of casein kinase I-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 9, R92. ... they both honed in on the gene CSNKe coding for protein kinase casein kinase 2 epsilon. Among its many multiple targets for ... 2010 Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134. doi:10.1016/j.cell.2010.06.011 (doi:10.1016/j.cell. ... A key mediator of cellular response to falling ATP levels is the AMP-dependent protein kinase AMPK, which in times of ...

http://rsob.royalsocietypublishing.org/content/3/1/120144.full

Like other casein kinase 1 protein family members, casein kinase 1 epsilon recognizes the Ser(p)XXSer/Thr motif for phosphorylation. (wikipedia.org)
Casein has been used as a substrate since the earliest days of research on protein phosphorylation. (wikipedia.org)
Casein kinase 1 epsilon has been suggested to play a role in phosphorylation of Disheveled in the Wnt signaling pathway. (wikipedia.org)
Casein kinase 1 alpha (CK1α) binds to and phosphorylates β‑catenin In plants the phosphorylation of protein Jade-1 is regulated by casein kinase 1. (wikipedia.org)
Various kinases have been described that regulate and modulate Wnt signaling through phosphorylation of Dishevelled. (biologists.org)
Receptor activation triggers phosphorylation of Lrp5/6 and the recruitment of Axin, Dvl, casein kinases and GSK3β to the receptor complex. (biologists.org)
Phosphorylation of CRY1 by Adenosine monophosphate-activated kinase (AMPK) enhances degradation of CRY1. (wikipathways.org)
Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. (wikipathways.org)
Tcf3 is a substrate for both glycogen synthase kinase (GSK) 3 and casein kinase (CK) 1epsilon, and phosphorylation of Tcf3 by CKIepsilon stimulates its binding to beta-catenin, an effect reversed by GSK3 . (xenbase.org)
Experiments combining kinase inhibition with inhibition of PER nuclear export suggest that phosphorylation directly affects PER repression activity and that PER nuclear localization is an indirect consequence of the association of active PER with DNA or chromatin. (nih.gov)
Shen B, Manley J. Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube. (labome.org)
In humans, a point mutation in a putative CKIε phosphorylation site within the kinase binding domain of human PER2 is sufficient to substantially shorten the free-running period ( 44 ). (asm.org)
PER and TIM proteins form a complex with the casein kinase 1ε ortholog DOUBLETIME (DBT), in which TIM helps protect PER from destabilization by DBT-mediated phosphorylation [10] - [12] . (prolekarniky.cz)
Casein kinases Idelta and Iepsilon (CKIdelta/epsilon) can regulate temporal abundance/activity of PER by phosphorylation-mediated degradation and cellular localization. (fsu.edu)
When CKIepsilon activity was disrupted by the DN-CKIepsilon in the mutant MEFs, circadian bioluminescence rhythms were eliminated and rhythms in endogenous PER abundance and phosphorylation were severely compromised, demonstrating that CKIdelta/epsilon are indeed essential kinases for the clockwork. (fsu.edu)

The protein encoded by the casein kinase 1 epsilon gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. (wikipedia.org)
By the late 1960s, cyclic AMP-dependent protein kinase had been purified, and most attention was centered on kinases and phosphatases that could regulate the activity of important enzymes. (wikipedia.org)
Protein kinase inhibitors have emerged as new drugs in various therapeutic areas, including leishmaniasis, an important parasitic disease. (asm.org)
Functional analysis of the homologous kinases and phosphatases in Drosophila median neurosecretory cells showed that atypical protein kinase C kinase and phosphatase PP2A regulate exocyst-dependent, insulin-like peptide secretion. (g3journal.org)

The Casein kinase 1 epsilon protein is part of the mammalian oscillator, a group of proteins that keep cells on a roughly 24-hour schedule. (wikipedia.org)
In order to perform experiments that would allow isolation and characterization of the enzymes involved in attaching and removing phosphate from proteins, there was a need for convenient substrates for protein kinases and protein phosphatases. (wikipedia.org)
Leishmania casein kinase 1 isoform 2 (CK1.2) has been identified as an exokinase capable of phosphorylating host proteins, thus exerting a potential immune-suppressive action on infected host cells. (asm.org)
PER and CRY proteins form complexes in the cytosol and these are bound by either CSNK1D or CSNK1E kinases which phosphorylate PER and CRY. (wikipathways.org)
In contrast, RNAi of the kinase par-1 caused reduced intracellular green fluorescent protein signal for the same proteins. (g3journal.org)
After Wnt activates signaling, CK1epsilon, CKII, PKCalpha , or Par-1 kinases hyperphosphorylate Dvl proteins on serine/threonine residues (Yanagawa et al. (atlasgeneticsoncology.org)
A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM. (bvsalud.org)
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (uniprot.org)
Genetic studies have identified CKIε (casein kinase Iε) as a key regulator of metazoan circadian rhythm and both genetic and biochemical studies suggest that the PER proteins are important substrates (reviewed in reference 10 ). (asm.org)
Structural and biophysical analyses revealed that Edo alters the packing of the highly conserved interdomain linker of the PER2 PAS core such that, although PER2(Edo) complexes with clock proteins, its vulnerability to degradation mediated by casein kinase 1ε (CSNK1E) is increased. (ox.ac.uk)
In vitro studies with chimeric proteins suggest that the inability of mPER3 to support circadian clock function results in part from lack of direct and stable interaction with casein kinase Iepsilon (CKIepsilon). (umassmed.edu)

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. (nih.gov)

Casein kinase I isoform epsilon or CK1ε, is an enzyme that is encoded by the CSNK1E gene in humans. (wikipedia.org)

Activation of Fz-LRP promotes the stability and nuclear localization of β-catenin by compromising the ability of a multiprotein complex containing axin, adenomatosis polyposis coli (APC) and glycogen synthase kinase 3 (GSK3) to target it for degradation and block its nuclear import. (biologists.org)
Glycogen synthase kinase 3 (GSK-3) is a multifunctional serine/threonine kinase found in all eukaryotes. (biologists.org)
The microtubule stabilizing function of DVL-1 is mimicked by lithium-mediated inhibition of glycogen synthase kinase-3ß (GSK-3ß) and blocked by expression of GSK-3ß. (sdbonline.org)

Additional, conflicting data concern the role of the atypical receptor tyrosine kinase Ryk, which might mediate Wnt signaling independently of Fz and/or function as a Fz co-receptor in some cells. (biologists.org)
Finally, we explore work implicating the kinase Ryk as a Wnt receptor and/or Fz co-receptor. (biologists.org)
The enzyme is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation. (biologists.org)
receptor tyrosine kinase-like orphan. (wikigenes.org)

Thus, this CKI consensus site requires priming by another kinase. (wikipedia.org)
Another peculiarity compared with other protein kinases is its preference for primed substrates, that is, substrates previously phosphorylated by another kinase. (biologists.org)

therefore, this kinase is very similar to other members of the casein kinase 1 family, of which there are seven mammalian isoforms (α, β, γ1, γ2, γ3, δ and ε). (wikipedia.org)
The identification of differences in structure and inhibition profiles compared to those of mammalian CK1 kinases opens new opportunities for Leishmania CK1.2 antileishmanial drug development. (asm.org)
Despite their potentially crucial effects on PER, it has not been demonstrated in a mammalian system that these kinases play essential roles in circadian rhythm generation as. (fsu.edu)

CKIε (casein kinase Iε) has been postulated to prime PER2 for degradation. (asm.org)

To identify regulators for exocyst function, we performed a targeted RNA interference (RNAi) screen in Caenorhabditis elegans to uncover kinases and phosphatases that genetically interact with the exocyst. (g3journal.org)
Collectively, these results characterize kinases and phosphatases implicated in the regulation of exocyst function, and suggest the possibility for interplay between the par-1 and pkc-3 kinases and the PP2A phosphatase regulatory subunit sur-6 in this process. (g3journal.org)

We identified seven kinase and seven phosphatase genes that display enhanced phenotypes when combined with hypomorphic alleles of exoc-7 ( exo70 ), exoc-8 ( exo84 ), or an exoc-7;exoc-8 double mutant. (g3journal.org)
Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. (umassmed.edu)

The results indicate that the two putative PER kinases DBT and CKII work together to phosphorylate PER and increase repression activity. (nih.gov)

The Casein kinase 1 family (EC 2.7.11.1) of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. (wikipedia.org)
The CK1 family of monomeric serine-threonine protein kinases is found in eukaryotic organisms from yeast to humans. (wikipedia.org)

The core β-Catenin destruction complex consists of β-Catenin, Adenomatous Polyposis Coli protein (APC), Axin, the kinases CK1 and GSK3β and the Ubiquitin ligase βTrCP. (biologists.org)

miR-9-5p in nephrectomy specimens is a potential predictor of primary resistance to first-line treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma. (mdc-berlin.de)

Casein Kinase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

These results underline the potential role of CK1 kinases in intracellular survival. (asm.org)
Our report provides the first chemical validation of Leishmania CK1 protein kinases, required for amastigote intracellular survival, as therapeutic targets. (asm.org)
Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION. (umassmed.edu)

Although highly homologous within their kinase domains (98% identity), the two gene products share only 36% identity in the last 76 C-terminal residues ( Woodgett, 1990 ). (biologists.org)

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. (labome.org)

Effect of high intensity ultrasound pretreatment on functional and structural properties of micellar casein concentrates. (bioportfolio.com)
This work investigated the impact of high intensity ultrasound (HIUS) pretreatment on the functional properties and structural characteristics of micellar casein concentrate (MCC). (bioportfolio.com)
In this paper, we report a novel functional role of casein kinase 1 (CK1) in the regulation of cell-cell contacts. (asm.org)

A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kD. (bioportfolio.com)

Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. (wikipedia.org)
In humans there are three casein kinase 1 gamma enzymes. (wikipedia.org)

Members of the Leishmania casein kinase 1 (CK1) family represent promising therapeutic targets. (asm.org)

The phosphorylated PER:CRY:kinase complex is translocated into the nucleus due to the nuclear localization signal of PER and CRY. (wikipathways.org)

Certain kinase-related structural motifs were subsequently confirmed, such as a β-strand-turn-β-strand motif that anchors ATP, a DFG motif that orients ATP's phosphates, a catalytic loop that resembles that of PKA, and major substrate recognition sites in the C-terminal domain. (wikipedia.org)
Hamsters with a semidominant mutation in the substrate recognition domain of CKIε exhibit shortened behavioral rhythms in vivo and decreased kinase activity in vitro ( 28 ). (asm.org)

Modification of IgE binding to α-casein by proteolytic activity of Enterococcus faecium isolated from Iranian camel milk samples. (bioportfolio.com)
This autophosphorylation occurs in the protein's C-Terminal domain, a region believed to behave as a pseudosubstrate, and inhibits kinase activity. (wikipedia.org)
Casein kinase activity associated with the endoplasmic reticulum of mammary glands was first characterized in 1974, and its activity was shown to not depend on cyclic AMP. (wikipedia.org)

The peripheral clocks can also be entrained independently by different factors such as external nutritional, hormonal and chemical cues that in many cases come from ligand modulation of nuclear receptors and kinase activators. (omicsonline.org)

Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C. The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. (umassmed.edu)

The family members have the highest homology in their kinase domains (53%-98% identical) and differ from most other protein kinases by the presence of the sequence S-I-N instead of A-P-E in kinase domain VIII. (wikipedia.org)
The glycine-rich N-terminal domain unique to GSK-3α and the conserved kinase domain shared by both isoforms are highlighted. (biologists.org)

It was officially identified as an isoform of the casein kinase 1 family. (wikipedia.org)

Protein kinases represent one of the most important groups of drug targets currently in development and are the targets of several Food and Drug Administration (FDA)-approved drugs against cancer ( 3 ). (asm.org)

Cream containing 2% (w/w) casein had better stability. (bioportfolio.com)

Our studies have shown that casein kinase I-epsilon (CKIe), a Wnt pathway protein, is significantly overexpressed in ovarian cancer tissues and is associated with poor survival. (edu.hk)

Anatomy2

Organisms8

Diseases2

Chemicals and Drugs12

Psychiatry and Psychology3

Phenomena and Processes9

Anthropology, Education, Sociology and Social Phenomena6

Named Groups2

Requirement of circadian genes for cocaine sensitization in Drosophila. (1/96)

double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. (2/96)

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. (3/96)

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. (4/96)

Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. (5/96)

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. (6/96)

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. (7/96)

Casein kinase Iepsilon modulates the signaling specificities of dishevelled. (8/96)

Casein Kinase Iepsilon

Casein Kinases

Casein Kinase Ialpha

Period Circadian Proteins

Casein Kinase II

Protein Kinases

Caseins

Casein Kinase I

Casein Kinase Idelta

Protein-Serine-Threonine Kinases

Body Patterning

Phosphoglycerate Mutase

Superstitions

Neural Tube

Wnt Proteins

Xenopus laevis

Embryo, Nonmammalian

Houseflies

Circadian Rhythm

Circadian Clocks

Diptera

Insects

Forensic Sciences

CLOCK Proteins

Biological Clocks

Cryptochromes

Nuclear Localization Signals

Drosophila melanogaster

Behavior, Animal

Sleep

Wakefulness

Darkness

Nelson Syndrome

Williams Syndrome

Education, Graduate

Faculty

Students

Education, Pharmacy, Graduate

Orthoreovirus

Vesicular Transport Proteins

Phosphorylation

Caenorhabditis elegans

Receptors, Notch

Drosophila

Receptor, Notch2

Drosophila Proteins

Receptor, Notch1

Glycogen Synthase Kinase 3

Requirement of circadian genes for cocaine sensitization in Drosophila. (1/96)

double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. (2/96)

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. (3/96)

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. (4/96)

Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. (5/96)

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. (6/96)

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. (7/96)

Casein kinase Iepsilon modulates the signaling specificities of dishevelled. (8/96)

Casein Kinase I epsilon and delta (CKI-epsilon and CKI-delta) from AMS Biotechnology (Archived Products) | SelectScience

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