Casein Kinase Ialpha: A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING.Cyclic GMP-Dependent Protein Kinase Type I: A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA.Cyclic GMP-Dependent Protein Kinases: A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.Casein Kinases: A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.Casein Kinase II: A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.Caseins: A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.Casein Kinase I: A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.Casein Kinase Iepsilon: A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM.Casein Kinase Idelta: A casein kinase I isoenzyme that plays a regulatory role in a variety of cellular functions including vesicular transport, CHROMOSOME SEGREGATION; CYTOKINESIS, developmental processes, and the CIRCADIAN RHYTHM.

Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide. (1/41)

At low concentrations, hydrogen peroxide (H(2)O(2)) is a positive endogenous regulator of mammalian cell proliferation and survival; however, the signal transduction pathways involved in these processes are poorly understood. In primary human endothelial cells, low concentrations of H(2)O(2) stimulated the rapid phosphorylation of the acidic C-terminal domain (ACD) of heterogeneous nuclear ribonucleoprotein C (hnRNP-C), a nuclear restricted pre-mRNA-binding protein, at Ser(240) and at Ser(225)-Ser(228). A kinase activity was identified in mouse liver that phosphorylates the ACD of hnRNP-C at Ser(240) and at two sites at Ser(225)-Ser(228). The kinase was purified and identified by tandem mass spectrometry as protein kinase CK1alpha (formerly casein kinase 1alpha). Protein kinase CK1alpha immunoprecipitated from primary human endothelial cell nuclei also phosphorylated the ACD of hnRNP-C at these positions. Pretreatment of endothelial cells with the protein kinase CK1-specific inhibitor IC261 prevented the H(2)O(2)-stimulated phosphorylation of hnRNP-C. Utilizing phosphoserine-mimicking Ser-to-Glu point mutations, the effects of phosphorylation on hnRNP-C function were investigated by quantitative equilibrium fluorescence RNA binding analyses. Wild-type hnRNP-C1 and hnRNP-C1 modified at the basal sites of phosphorylation (S247E and S286E) both avidly bound RNA with similar binding constants. In contrast, hnRNP-C1 that was also modified at the CK1alpha phosphorylation sites exhibited a 14-500-fold decrease in binding affinity, demonstrating that CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C.  (+info)

Physiological role for casein kinase 1 in glutamatergic synaptic transmission. (2/41)

Casein kinase 1 (CK1) is a highly conserved serine/threonine kinase, present in virtually all cell types, in which it phosphorylates a wide variety of substrates. So far, no role has been found for this ubiquitous protein kinase in the physiology of nerve cells. In the present study, we show that CK1 regulates fast synaptic transmission mediated by glutamate, the major excitatory neurotransmitter in the brain. Through the use of CK1 inhibitors, we present evidence that activation of CK1 decreases NMDA receptor activity in the striatum via a mechanism that involves activation by this kinase of protein phosphatase 1 and/or 2A and resultant increased dephosphorylation of NMDA receptors. Indeed, inhibition of CK1 increases NMDA-mediated EPSCs in medium spiny striatal neurons. This effect is associated with an increased phosphorylation of the NR1 and NR2B subunits of the NMDA receptor and is occluded by the phosphatase inhibitor okadaic acid. The mGluR1, but not mGluR5, subclass of metabotropic glutamate receptors uses CK1 to inhibit NMDA-mediated synaptic currents. These results provide the first evidence for a role of CK1 in the regulation of synaptic transmission in the brain.  (+info)

Regulation of p53-MDMX interaction by casein kinase 1 alpha. (3/41)

MDMX is a homolog of MDM2 that is critical for regulating p53 function during mouse development. MDMX degradation is regulated by MDM2-mediated ubiquitination. Whether there are other mechanisms of MDMX regulation is largely unknown. We found that MDMX binds to the casein kinase 1 alpha isoform (CK1alpha) and is phosphorylated by CK1alpha. Expression of CK1alpha stimulates the ability of MDMX to bind to p53 and inhibit p53 transcriptional function. Regulation of MDMX-p53 interaction requires CK1alpha binding to the central region of MDMX and phosphorylation of MDMX on serine 289. Inhibition of CK1alpha expression by isoform-specific small interfering RNA (siRNA) activates p53 and further enhances p53 activity after ionizing irradiation. CK1alpha siRNA also cooperates with DNA damage to induce apoptosis. These results suggest that CK1alpha is a functionally relevant MDMX-binding protein and plays an important role in regulating p53 activity in the absence or presence of stress.  (+info)

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. (4/41)

FADD is essential for death receptor (DR)-induced apoptosis. However, it is also critical for cell cycle progression and proliferation, activities that are regulated by phosphorylation of its C-terminal Ser194, which has also been implicated in sensitizing cancer cells to chemotherapeutic drugs and in regulating FADD's intracellular localization. We now demonstrate that casein kinase Ialpha (CKIalpha) phosphorylates FADD at Ser194 both in vitro and in vivo. FADD-CKIalpha association regulates the subcellular localization of FADD, and phosphorylated FADD was found to colocalize with CKIalpha on the spindle poles in metaphase. Inhibition of CKIalpha diminished FADD phosphorylation, prevented the ability of Taxol to arrest cells in mitosis, and blocked mitogen-induced proliferation of mouse splenocytes. In contrast, a low level of cycling splenocytes from mice expressing FADD with a mutated phosphorylation site was insensitive to CKI inhibition. These data suggest that phosphorylation of FADD by CKI is a crucial event during mitosis.  (+info)

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. (5/41)

Hedgehog (Hh) proteins govern animal development by regulating the Gli/Ci family of transcription factors. In Drosophila, Hh signaling blocks proteolytic processing of full-length Ci to generate a truncated repressor form. Ci processing requires sequential phosphorylation by PKA, GSK3, and a casein kinase I (CKI) family member(s). Here we show that Double-time (DBT)/CKIepsilon and CKIalpha act in conjunction to promote Ci processing. CKI phosphorylates Ci at three clusters of serine residues primed by PKA and GSK3 phosphorylation. CKI phosphorylation of Ci confers binding to the F-box protein Slimb/beta-TRCP, the substrate recognition component of the SCF(Slimb/beta-TRCP) ubiquitin ligase required for Ci processing. CKI phosphorylation sites act cooperatively to promote Ci processing in vivo. Substitution of Ci phosphorylation clusters with a canonical Slimb/beta-TRCP recognition motif in beta-catenin renders Slimb/beta-TRCP binding and Ci processing independent of CKI. We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP).  (+info)

Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. (6/41)

Forkhead transcription factors play critical roles in the maintenance of immune homeostasis. In this study, we demonstrate that this regulation most likely involves intricate interactions between the forkhead family members and inflammatory transcription factors: the forkhead member Foxd1 coordinates the regulation of the activity of two key inflammatory transcription factors, NF-AT and NF-kappaB, with Foxd1 deficiency resulting in multiorgan, systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autologous MLRs. Foxd1-deficient T cells possess increased activity of both NF-AT and NF-kappaB: the former correlates with the ability of Foxd1 to regulate casein kinase 1, an NF-AT inhibitory kinase; the latter with the ability of Foxd1 to regulate Foxj1, which regulates the NF-kappaB inhibitory subunit IkappaB beta. Thus, Foxd1 modulates inflammatory reactions and prevents autoimmunity by directly regulating anti-inflammatory regulators of the NF-AT pathway, and by coordinating the suppression of the NF-kappaB pathway via Foxj1. These findings indicate the presence of a general network of forkhead proteins that enforce T cell quiescence.  (+info)

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. (7/41)

Members of the casein kinase I (CKI) family have been implicated in regulating canonical Wnt/Wingless (Wg) signaling by phosphorylating multiple pathway components. Overexpression of CKI in vertebrate embryos activates Wg signaling, and one target is thought to be the cytoplasmic effector Dishevelled (Dsh), which is an in vitro target of CKI phosphorylation. Phosphorylation of Dsh by CKI has also been suggested to switch its activity from noncanonical to canonical Wingless signaling. However, in vivo loss-of-function experiments have failed to identify a clear role for CKI in positive regulation of Wg signaling. By examining hypomorphic mutations of the Drosophila CKIepsilon homolog discs overgrown (dco)/double-time, we now show that it is an essential component of the noncanonical/planar cell polarity pathway. Genetic interactions indicate that dco acts positively in planar polarity signaling, demonstrating that it does not act as a switch between canonical and noncanonical pathways. Mutations in dco result in a reduced level of Dishevelled phosphorylation in vivo. Furthermore, in these mutants, Dishevelled fails to adopt its characteristic asymmetric subcellular localisation at the distal end of pupal wing cells, and the site of hair outgrowth is disrupted. Finally, we also find that dco function in polarity is partially redundant with CKIalpha.  (+info)

Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. (8/41)

Wnt-5a has been shown to influence the metastatic behavior of human breast cancer cells, and the loss of Wnt-5a expression is associated with metastatic disease. We show here that NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells. This activation was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway. The observation that inhibition of the Wnt-5a/Yes/Cdc42 signal prolonged the duration of ionomycin-induced NFAT1 activation revealed the general importance of this pathway. The Wnt-5a-induced inhibition of NFAT1 did not require glycogen synthase kinase 3beta, JNK, or Pak1 activity or modulation of the cytoskeleton. Instead, we observed that Wnt-5a induced a complex formation of NFAT1/casein kinase 1alpha, even upon treatment with ionomycin, which was blocked upon inhibition of the Wnt-5a/Yes/Cdc42 signaling pathway. Our results explain why Wnt-5a/Ca2+-induced NFAT activity is hard to detect and suggest a novel mechanism by which Wnt-5a can suppress tumor-specific, agonist-induced NFAT activity and thus the metastatic behavior of breast cancer cells.  (+info)

*Centaurin, alpha 1

"Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1-3): 167-71. doi:10.1016/s0014-5793( ... Casein kinase 1, alpha 1 Nucleolin, P110α, PRKCI, Protein kinase D1, and Protein kinase Mζ. Model organisms have been used in ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ...

*ERF (gene)

Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners ... "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation". ...

*PPP1R14A

Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ... "Association of CPI-17 with protein kinase C and casein kinase I". Biochem. Biophys. Res. Commun. 316 (1): 39-47. doi:10.1016/j. ... Multiple kinases are identified to phosphorylate CPI-17, such as PKC, ROCK, PKN, ZIPK, ILK, and PAK. Agonist stimulation of ... Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 ...

*SYT9

Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological ... "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological ...

*AP3B1

Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... Kim YM, Barak LS, Caron MG, Benovic JL (May 2002). "Regulation of arrestin-3 phosphorylation by casein kinase II". The Journal ...

*HMGB2

Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in ...

*AP3B2

"The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform". ...

*List of MeSH codes (D08)

... casein kinase i MeSH D08.811.913.696.620.682.700.140.300.100 --- casein kinase ialpha MeSH D08.811.913.696.620.682.700.140. ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ... map kinase kinase kinase 4 MeSH D08.811.913.696.620.682.700.559.500 --- map kinase kinase kinase 5 MeSH D08.811.913.696.620.682 ...

*List of MeSH codes (D12.776.476)

... casein kinase ialpha MeSH D12.776.476.150.300.200 -- casein kinase idelta MeSH D12.776.476.150.300.300 -- casein kinase ... cdc2 protein kinase MeSH D12.776.476.250.067.500 -- cdc28 protein kinase, s cerevisiae MeSH D12.776.476.250.067.875 -- cyclin- ... dependent kinase 5 MeSH D12.776.476.250.067.900 -- cyclin-dependent kinase 9 MeSH D12.776.476.250.580.500 -- cdc2 protein ... mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 -- mitogen-activated protein kinase 3 MeSH D12.776.476.450. ...

*List of MeSH codes (D12.644)

... casein kinase i MeSH D12.644.360.150.300.100 --- casein kinase ialpha MeSH D12.644.360.150.300.200 --- casein kinase idelta ... map kinase kinase kinase 1 MeSH D12.644.360.400.200 --- map kinase kinase kinase 2 MeSH D12.644.360.400.300 --- map kinase ... kinase kinase 3 MeSH D12.644.360.400.400 --- map kinase kinase kinase 4 MeSH D12.644.360.400.500 --- map kinase kinase kinase 5 ... map kinase kinase 1 MeSH D12.644.360.440.200 --- map kinase kinase 2 MeSH D12.644.360.440.300 --- map kinase kinase 3 MeSH ...

*Casein kinase 1, alpha 1

Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. Casein kinase 1, alpha 1 has been ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024576 ...

*CHKA

Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ... Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat ... Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. The major pathway for the biosynthesis of ... 1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4 ...
Casein Kinase Ialpha: A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the CELL CYCLE, membrane trafficking, and RNA processing. In DROSOPHILA casein kinase Ialpha has been in regulation of Hedghog and Wingless signaling pathways. Multiple isoforms of casein kinase Ialpha exist and are due ALTERNATIVE SPLICING.
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Expression of CSNK1A1 (CK1, CK1a, CK1alpha, CKIa, CKIalpha) in soft tissue 2 tissue. Antibody staining with CAB016680 in immunohistochemistry.
GF ID PRKG1_interact #=GF AC PF15898.5 #=GF DE cGMP-dependent protein kinase interacting domain #=GF AU Eberhardt R;0000-0001-6152-1369 #=GF SE Jackhmmer:A8JNT6 #=GF GA 32.40 32.40; #=GF TC 33.30 32.50; #=GF NC 32.30 32.30; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 12873707 #=GF RT Dimerization of cGMP-dependent protein kinase 1alpha and the #=GF RT myosin-binding subunit of myosin phosphatase: role of leucine #=GF RT zipper domains. #=GF RA Surks HK, Mendelsohn ME; #=GF RL Cell Signal. 2003;15:937-944. #=GF RN [2] #=GF RM 10567269 #=GF RT Regulation of myosin phosphatase by a specific interaction with #=GF RT cGMP- dependent protein kinase Ialpha. #=GF RA Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, #=GF RA Lincoln TM, Mendelsohn ME; #=GF RL Science. 1999;286:1583-1587. #=GF DR INTERPRO; IPR031775; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This domain is found at the C-terminus ...
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The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a large number of human cancers. The pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), a key signaling effector of the HH pathway that regulates the levels and activity of the Gli family of transcription factors. Although one of these compounds, vismodegib, is now FDA-approved for patients with advanced basal cell carcinoma, acquired mutations in Smo can result in rapid relapse. Furthermore, many cancers also exhibit a Smo-independent activation of Gli proteins, an observation that may underlie the limited efficacy of Smo inhibitors in clinical trials against other types of cancer. Thus, there remains a critical need for HH inhibitors with different mechanisms of action, particularly those that act downstream of Smo. Recently, we identified the FDA-approved anti-pinworm compound pyrvinium as ...
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Summary of CSNK1E (CKIE, CKIepsilon, HCKIE) expression in human tissue. Mainly cytoplasmic and nuclear expression in several tissues.
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Casein Kinase Ialpha
     Summary Report | CureHunterCasein Kinase Ialpha Summary Report | CureHunter

In DROSOPHILA casein kinase Ialpha has been in regulation of Hedghog and Wingless signaling pathways. Multiple isoforms of ... casein kinase Ialpha exist and are due ALTERNATIVE SPLICING. ... A casein kinase I isoenzyme that plays a role in intracellular ... Protein Kinases: 9706*Protein-Serine-Threonine Kinases: 1353*Casein Kinases: 99*Casein Kinase I: 50*Casein Kinase Ialpha ... Casein Kinase Ialpha. Subscribe to New Research on Casein Kinase Ialpha A casein kinase I isoenzyme that plays a role in ...
more infohttp://www.curehunter.com/public/keywordSummaryD048128-Casein-Kinase-Ialpha.do

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.  - PubMed - NCBIControl of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. - PubMed - NCBI

This "priming" kinase is casein kinase Ialpha (CKIalpha). Depletion of CKIalpha inhibits beta-catenin phosphorylation and ... Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.. Liu C1, Li Y, Semenov M, Han C, Baeg GH, Tan Y ... which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and ... adnomatous polyposis coli (APC). Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/11955436?dopt=Abstract

Effect of casein and inulin addition on physico-chemical characteristics of low fat camel dairy cream.Effect of casein and inulin addition on physico-chemical characteristics of low fat camel dairy cream.

The effect of the addition of the camel casein fraction on some physico-chemical properties of low fat camel milk cream was ... Casein Kinase Ialpha. A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the CELL ... Casein Kinase I. A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kD. ... Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2053481/Effect-of-casein-and-inulin-addition-on-physico-chemical-characteristics-of-low.html

Casein kinase 1, alpha 1 - WikipediaCasein kinase 1, alpha 1 - Wikipedia

Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. Casein kinase 1, alpha 1 has been ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024576 ...
more infohttps://en.wikipedia.org/wiki/Casein_kinase_1,_alpha_1

Centaurin, alpha 1 - WikipediaCentaurin, alpha 1 - Wikipedia

"Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1-3): 167-71. doi:10.1016/s0014-5793( ... Casein kinase 1, alpha 1 Nucleolin, P110α, PRKCI, Protein kinase D1, and Protein kinase Mζ. Model organisms have been used in ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ...
more infohttps://en.wikipedia.org/wiki/Centaurin,_alpha_1

Active Human Casein Kinase 1, alpha 1 (CSNK1A1) Protein (GST tag), Recombinant | ABIN2003196Active Human Casein Kinase 1, alpha 1 (CSNK1A1) Protein (GST tag), Recombinant | ABIN2003196

Recombinant Casein Kinase 1, alpha 1 (CSNK1A1) Protein (GST tag). Spezies: Human. Quelle: Baculovirus infected Insect Cells. ... casein kinase 1 alpha 1 L homeolog * Casein kinase Ialpha * CSNK1A1 * KRT1 ... Casein Kinase 1, alpha 1 (CSNK1A1) (AA 1-337), (full length) (Active) protein (GST tag). Details zu Produkt Nr. ABIN2003196, ... Casein Kinase 1, alpha 1 (CSNK1A1) Synonyme für dieses Antigen anzeigen * CK1 ...
more infohttps://www.antikoerper-online.de/protein/2003196/Casein+Kinase+1,+alpha+1+CSNK1A1+AA+1-337,+full+length+Active+protein+GST+tag/

ERF (gene) - wikidocERF (gene) - wikidoc

Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners ... "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation" ...
more infohttps://www.wikidoc.org/index.php?title=ERF_

IMP: Integrative Multi-species PredictionIMP: Integrative Multi-species Prediction

Casein kinase Ialpha. 0.027. pigeon. CG10739 gene product from transcript CG10739-RB. 0.026. ...
more infohttp://imp.princeton.edu/predictions/process/fly-context-global/14865/?gene=140213

Adaptor protein complexes and intracellular transport | Bioscience ReportsAdaptor protein complexes and intracellular transport | Bioscience Reports

2000) The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like ... 2003) ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type ...
more infohttp://www.bioscirep.org/content/34/4/e00123?ijkey=c1433340857899c20224106c47a08b1eeee5d846&keytype2=tf_ipsecsha

IMP: Integrative Multi-species PredictionIMP: Integrative Multi-species Prediction

Casein kinase Ialpha. 0.032. luna. CG33473 gene product from transcript CG33473-RB. 0.032. ...
more infohttp://imp.princeton.edu/predictions/process/fly-context-global/6714/?gene=149998

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.  - PubMed - NCBISmall-molecule inhibition of Wnt signaling through activation of casein kinase 1α. - PubMed - NCBI

Casein Kinase I/genetics. *Casein Kinase I/metabolism. *Casein Kinase Ialpha/metabolism* ... family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase ... Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.. Thorne CA1, Hanson AJ, Schneider J, Tahinci ... Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/20890287

Robust hepatitis C virus infection in vitro | PNASRobust hepatitis C virus infection in vitro | PNAS

Involvement of Hepatitis C Virus NS5A Hyperphosphorylation Mediated by Casein Kinase I-{alpha} in Infectious Virus Production ...
more infohttps://www.pnas.org/content/102/26/9294.full

Casein Kinase I | Profiles RNSCasein Kinase I | Profiles RNS

Casein Kinase I. *Casein Kinase Ialpha. *Casein Kinase Idelta. *Casein Kinase Iepsilon ... Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I ... "Casein Kinase I" by people in this website by year, and whether "Casein Kinase I" was a major or minor topic of these ... "Casein Kinase I" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
more infohttps://profiles.umassmed.edu/display/121053

Sex-chromosome anaphase movements in crane-fly spermatocytes are coordinated: ultraviolet microbeam irradiation of one...Sex-chromosome anaphase movements in crane-fly spermatocytes are coordinated: ultraviolet microbeam irradiation of one...

The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA ...
more infohttp://jcs.biologists.org/content/88/4/441

Pharmacological evidence for a role for cyclic AMP signalling in Dictyostelium discoideum slug behaviour | Journal of Cell...Pharmacological evidence for a role for cyclic AMP signalling in Dictyostelium discoideum slug behaviour | Journal of Cell...

The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA ...
more infohttp://jcs.biologists.org/content/96/4/661

Angus Clark Nairn, PhD > Psychiatry | Yale School of...Angus Clark Nairn, PhD > Psychiatry | Yale School of...

Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 2001 ... and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent ... by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Eur J Biochem. 1990 Sep 11 ... calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. J Biol Chem. 1998 ...
more infohttp://medicine.yale.edu/psychiatry/people/angus_nairn-2.profile

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Casein Kinase Ialpha - genetics , Glycogen Synthase Kinase 3 beta , Thalidomide - pharmacology , Wnt Proteins - metabolism , ... SYNTHASE KINASE 3 , Casein Kinase Ialpha - biosynthesis , Cyclin D1 - metabolism , Gene Expression Regulation, Enzymologic - ... Glycogen Synthase Kinase 3 beta , Ribosomal Protein S6 Kinases, 70-kDa - physiology , MAP Kinase Kinase 1 - physiology , ... Phosphatidylinositol-3-kinase , Infarct size , Protein kinase C , Akt , PERMEABILITY TRANSITION PORE , PROTEIN-KINASE-C , ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Glycogen%20Synthase%20Kinase%203%20-%20biosynthesis

Biological sciencesBiological sciences

Abstracts: Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Monoallelically expressed ... The structure of the G protein Heterotrimer G(sub i-alpha)-beta(sub 1)-gamma (sub 2) ... Abstracts: Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock. The death domain kinase RIP has ... Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development ...
more infohttp://www.faqs.org/abstracts/Biological-sciences/p-56-Abstracts.html

Role of cyclic GMP-dependent protein kinase type II in the brain - UBC Library Open CollectionsRole of cyclic GMP-dependent protein kinase type II in the brain - UBC Library Open Collections

... and cGMP-dependent protein kinases, protein kinase C , calmodulin-dependent protein kinase U and casein kinase LT. Eur J ... Identification of the amino acid sequences responsible for high affinity activation of c G M P kinase Ialpha. J Biol Chem. 272: ... Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. Faseb J. ... Regulation of myosin phosphatase by a specific interaction with c G M P - dependent protein kinase Ialpha. Science. 286:1583-7 ...
more infohttps://open.library.ubc.ca/cIRcle/collections/ubctheses/831/items/1.0092443

Lee, Mol Vis 2003; 9:624-634.Lee, Mol Vis 2003; 9:624-634.

Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. J Biol ... Trichostatin A inhibits beta-casein expression in mammary epithelial cells. J Cell Biochem 2001; 83:660-70. ... were used to block PI 3-kinase, Rho, Rho associated kinase, extracellular signal regulated kinase, or FGF-2 pathways. ... These were LY294002 (PI 3-kinase, 20 μM), PD98059 (extracellular signal regulated kinase, ERK, 10 μM), C3 exoenzyme (Rho, 5 μg/ ...
more infohttp://www.molvis.org/molvis/v9/a76/

anti-CSNK1A1 antibody (Casein Kinase 1, alpha 1)  (Biotin)</span...anti-CSNK1A1 antibody (Casein Kinase 1, alpha 1) (Biotin)</span...

anti-CSNK1A1 antibody (Casein Kinase 1, alpha 1) (Biotin) CSNK1A1 antibody (Casein Kinase 1, alpha 1) (Biotin). Details for ... Casein Kinase 1, alpha 1 (CSNK1A1) show synonyms for this antigen * CK1 ... casein kinase 2 alpha 1 * Casein kinase Ialpha * CSNK1A1 * Csnk1a1 * csnk1a1 * KRT1 ... anti-Casein Kinase 2, alpha 1 Polypeptide Antibodies * anti-Casein Kinase 2, alpha Prime Polypeptide Antibodies ...
more infohttps://www.antibodies-online.com/antibody/6868096/anti-Casein+Kinase+1,+alpha+1+CSNK1A1+antibody+Biotin/

CAMP-dependent protein kinase | definition of cAMP-dependent protein kinase by Medical dictionaryCAMP-dependent protein kinase | definition of cAMP-dependent protein kinase by Medical dictionary

... cAMP-dependent protein kinase explanation free. What is cAMP-dependent protein kinase? Meaning of cAMP-dependent protein kinase ... Looking for online definition of cAMP-dependent protein kinase in the Medical Dictionary? ... which is not phosphorylated by either cAMP-dependent protein kinase (PKA), casein kinases I and II, [Ca.. Settlement and ... cAMP-dependent protein kinase type-I-alpha regulatory chain. *cAMP-dependent protein kinase type-I-alpha regulatory subunit ...
more infohttps://medical-dictionary.thefreedictionary.com/cAMP-dependent+protein+kinase
  • beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). (nih.gov)
  • Casein Kinase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the CELL CYCLE, membrane trafficking, and RNA processing. (curehunter.com)