Casein Kinase Ialpha
Cyclic GMP-Dependent Protein Kinase Type I
Cyclic GMP-Dependent Protein Kinases
Casein Kinases
A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.
Casein Kinase II
Caseins
Casein Kinase I
A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.
Casein Kinase Iepsilon
Casein Kinase Idelta
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Axin Protein
Glycogen Synthase Kinase 3
Publishing
Glaucoma Drainage Implants
Ethylenes
Plant Somatic Embryogenesis Techniques
Proto-Oncogene Proteins c-ets
Chromosome Mapping
Birefringence
Spermatocytes
Sex Chromosomes
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Diptera
An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, SARCOPHAGIDAE, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).
Anaphase
Orthoptera
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Dictyostelium
Cyclic AMP
Receptors, Cyclic AMP
Cell surface proteins that bind cyclic AMP with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized cyclic AMP receptors are those of the slime mold Dictyostelium discoideum. The transcription regulator CYCLIC AMP RECEPTOR PROTEIN of prokaryotes is not included nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.
Cyclic AMP Receptor Protein
A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.
Amoeba
Myxomycetes
Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide. (1/41)
At low concentrations, hydrogen peroxide (H(2)O(2)) is a positive endogenous regulator of mammalian cell proliferation and survival; however, the signal transduction pathways involved in these processes are poorly understood. In primary human endothelial cells, low concentrations of H(2)O(2) stimulated the rapid phosphorylation of the acidic C-terminal domain (ACD) of heterogeneous nuclear ribonucleoprotein C (hnRNP-C), a nuclear restricted pre-mRNA-binding protein, at Ser(240) and at Ser(225)-Ser(228). A kinase activity was identified in mouse liver that phosphorylates the ACD of hnRNP-C at Ser(240) and at two sites at Ser(225)-Ser(228). The kinase was purified and identified by tandem mass spectrometry as protein kinase CK1alpha (formerly casein kinase 1alpha). Protein kinase CK1alpha immunoprecipitated from primary human endothelial cell nuclei also phosphorylated the ACD of hnRNP-C at these positions. Pretreatment of endothelial cells with the protein kinase CK1-specific inhibitor IC261 prevented the H(2)O(2)-stimulated phosphorylation of hnRNP-C. Utilizing phosphoserine-mimicking Ser-to-Glu point mutations, the effects of phosphorylation on hnRNP-C function were investigated by quantitative equilibrium fluorescence RNA binding analyses. Wild-type hnRNP-C1 and hnRNP-C1 modified at the basal sites of phosphorylation (S247E and S286E) both avidly bound RNA with similar binding constants. In contrast, hnRNP-C1 that was also modified at the CK1alpha phosphorylation sites exhibited a 14-500-fold decrease in binding affinity, demonstrating that CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C. (+info)Physiological role for casein kinase 1 in glutamatergic synaptic transmission. (2/41)
Casein kinase 1 (CK1) is a highly conserved serine/threonine kinase, present in virtually all cell types, in which it phosphorylates a wide variety of substrates. So far, no role has been found for this ubiquitous protein kinase in the physiology of nerve cells. In the present study, we show that CK1 regulates fast synaptic transmission mediated by glutamate, the major excitatory neurotransmitter in the brain. Through the use of CK1 inhibitors, we present evidence that activation of CK1 decreases NMDA receptor activity in the striatum via a mechanism that involves activation by this kinase of protein phosphatase 1 and/or 2A and resultant increased dephosphorylation of NMDA receptors. Indeed, inhibition of CK1 increases NMDA-mediated EPSCs in medium spiny striatal neurons. This effect is associated with an increased phosphorylation of the NR1 and NR2B subunits of the NMDA receptor and is occluded by the phosphatase inhibitor okadaic acid. The mGluR1, but not mGluR5, subclass of metabotropic glutamate receptors uses CK1 to inhibit NMDA-mediated synaptic currents. These results provide the first evidence for a role of CK1 in the regulation of synaptic transmission in the brain. (+info)Regulation of p53-MDMX interaction by casein kinase 1 alpha. (3/41)
MDMX is a homolog of MDM2 that is critical for regulating p53 function during mouse development. MDMX degradation is regulated by MDM2-mediated ubiquitination. Whether there are other mechanisms of MDMX regulation is largely unknown. We found that MDMX binds to the casein kinase 1 alpha isoform (CK1alpha) and is phosphorylated by CK1alpha. Expression of CK1alpha stimulates the ability of MDMX to bind to p53 and inhibit p53 transcriptional function. Regulation of MDMX-p53 interaction requires CK1alpha binding to the central region of MDMX and phosphorylation of MDMX on serine 289. Inhibition of CK1alpha expression by isoform-specific small interfering RNA (siRNA) activates p53 and further enhances p53 activity after ionizing irradiation. CK1alpha siRNA also cooperates with DNA damage to induce apoptosis. These results suggest that CK1alpha is a functionally relevant MDMX-binding protein and plays an important role in regulating p53 activity in the absence or presence of stress. (+info)Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. (4/41)
FADD is essential for death receptor (DR)-induced apoptosis. However, it is also critical for cell cycle progression and proliferation, activities that are regulated by phosphorylation of its C-terminal Ser194, which has also been implicated in sensitizing cancer cells to chemotherapeutic drugs and in regulating FADD's intracellular localization. We now demonstrate that casein kinase Ialpha (CKIalpha) phosphorylates FADD at Ser194 both in vitro and in vivo. FADD-CKIalpha association regulates the subcellular localization of FADD, and phosphorylated FADD was found to colocalize with CKIalpha on the spindle poles in metaphase. Inhibition of CKIalpha diminished FADD phosphorylation, prevented the ability of Taxol to arrest cells in mitosis, and blocked mitogen-induced proliferation of mouse splenocytes. In contrast, a low level of cycling splenocytes from mice expressing FADD with a mutated phosphorylation site was insensitive to CKI inhibition. These data suggest that phosphorylation of FADD by CKI is a crucial event during mitosis. (+info)Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. (5/41)
Hedgehog (Hh) proteins govern animal development by regulating the Gli/Ci family of transcription factors. In Drosophila, Hh signaling blocks proteolytic processing of full-length Ci to generate a truncated repressor form. Ci processing requires sequential phosphorylation by PKA, GSK3, and a casein kinase I (CKI) family member(s). Here we show that Double-time (DBT)/CKIepsilon and CKIalpha act in conjunction to promote Ci processing. CKI phosphorylates Ci at three clusters of serine residues primed by PKA and GSK3 phosphorylation. CKI phosphorylation of Ci confers binding to the F-box protein Slimb/beta-TRCP, the substrate recognition component of the SCF(Slimb/beta-TRCP) ubiquitin ligase required for Ci processing. CKI phosphorylation sites act cooperatively to promote Ci processing in vivo. Substitution of Ci phosphorylation clusters with a canonical Slimb/beta-TRCP recognition motif in beta-catenin renders Slimb/beta-TRCP binding and Ci processing independent of CKI. We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP). (+info)Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. (6/41)
Forkhead transcription factors play critical roles in the maintenance of immune homeostasis. In this study, we demonstrate that this regulation most likely involves intricate interactions between the forkhead family members and inflammatory transcription factors: the forkhead member Foxd1 coordinates the regulation of the activity of two key inflammatory transcription factors, NF-AT and NF-kappaB, with Foxd1 deficiency resulting in multiorgan, systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autologous MLRs. Foxd1-deficient T cells possess increased activity of both NF-AT and NF-kappaB: the former correlates with the ability of Foxd1 to regulate casein kinase 1, an NF-AT inhibitory kinase; the latter with the ability of Foxd1 to regulate Foxj1, which regulates the NF-kappaB inhibitory subunit IkappaB beta. Thus, Foxd1 modulates inflammatory reactions and prevents autoimmunity by directly regulating anti-inflammatory regulators of the NF-AT pathway, and by coordinating the suppression of the NF-kappaB pathway via Foxj1. These findings indicate the presence of a general network of forkhead proteins that enforce T cell quiescence. (+info)Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. (7/41)
Members of the casein kinase I (CKI) family have been implicated in regulating canonical Wnt/Wingless (Wg) signaling by phosphorylating multiple pathway components. Overexpression of CKI in vertebrate embryos activates Wg signaling, and one target is thought to be the cytoplasmic effector Dishevelled (Dsh), which is an in vitro target of CKI phosphorylation. Phosphorylation of Dsh by CKI has also been suggested to switch its activity from noncanonical to canonical Wingless signaling. However, in vivo loss-of-function experiments have failed to identify a clear role for CKI in positive regulation of Wg signaling. By examining hypomorphic mutations of the Drosophila CKIepsilon homolog discs overgrown (dco)/double-time, we now show that it is an essential component of the noncanonical/planar cell polarity pathway. Genetic interactions indicate that dco acts positively in planar polarity signaling, demonstrating that it does not act as a switch between canonical and noncanonical pathways. Mutations in dco result in a reduced level of Dishevelled phosphorylation in vivo. Furthermore, in these mutants, Dishevelled fails to adopt its characteristic asymmetric subcellular localisation at the distal end of pupal wing cells, and the site of hair outgrowth is disrupted. Finally, we also find that dco function in polarity is partially redundant with CKIalpha. (+info)Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. (8/41)
Wnt-5a has been shown to influence the metastatic behavior of human breast cancer cells, and the loss of Wnt-5a expression is associated with metastatic disease. We show here that NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells. This activation was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway. The observation that inhibition of the Wnt-5a/Yes/Cdc42 signal prolonged the duration of ionomycin-induced NFAT1 activation revealed the general importance of this pathway. The Wnt-5a-induced inhibition of NFAT1 did not require glycogen synthase kinase 3beta, JNK, or Pak1 activity or modulation of the cytoskeleton. Instead, we observed that Wnt-5a induced a complex formation of NFAT1/casein kinase 1alpha, even upon treatment with ionomycin, which was blocked upon inhibition of the Wnt-5a/Yes/Cdc42 signaling pathway. Our results explain why Wnt-5a/Ca2+-induced NFAT activity is hard to detect and suggest a novel mechanism by which Wnt-5a can suppress tumor-specific, agonist-induced NFAT activity and thus the metastatic behavior of breast cancer cells. (+info)
Casein Kinase Ialpha
Summary Report | CureHunter
9 Mistakes In fake tan for pale skin reviews That allow you to Look Dumb | Guide for Sunless Home Tanning
Tissue expression of CSNK1A1 - Staining in soft tissue 2 - The Human Protein Atlas
Pfam: PRKG1 interact
Placental DEPTOR as a stress sensor during pregnancy.
GLIPR2 - PrimePCR Assay and Template | Life Science | Bio-Rad
GLIPR1 - PrimePCR Assay and Template | Life Science | Bio-Rad
Pyrvinium attenuates Hedgehog signaling downstream of smoothened. | Lee Lab
The American Journal of Tropical Medicine and Hygiene | A Case of Apparent Photosensitization Due to Pyrvinium Pamoate*
Casein Kinase Protein | CK2 | CSNK1 | CSNK2 | ProSpec
Gentaur Molecular :Jena Bio \ anti-hCK2, beta-subunit anti-human casein kinase 2, beta-subunitmurine, monoclonal \ ABD-020
Casein Kinase 1 delta肽(ab48070)|Abcam中国
Glipr1 - mouse gene knockout kit via CRISPR - KN306517 | acris-antibodies.com
GLIPR2 knockout cell line
DEPTOR ELISA & Assay Kits
MICELLAR CASEIN БЕЛКОВЫЙ ПОРОШОК С МИЦЕЛЯРНЫМ КАЗЕИНОМ, БЕЗ САХАРА, БЕЗ ГЛЮТЕНА, БЕЗ ЖИРА
CK2 alpha | casein kinase 2 subunit alpha
The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development
CK2 beta | casein kinase 2 subunit beta
Casein Protein | Casein Protein Powder | The Protein Works
Casein Kinase I epsilon and delta (CKI-epsilon and CKI-delta) from AMS Biotechnology (Archived Products) | SelectScience
Casein Paint - squint your eyes
Tissue expression of CSNK1E - Summary - The Human Protein Atlas
What is Casein Protein and its Benefits
사다 Pure En캡슐ulations 60 V캡슐을 실리마린 (silymarin) 한국
Casein kinase 2 and protein substrates are released from rat liver cells nuclei by DNase or RNase digestion<...
Gentaur Molecular :Ray Biotech \ Recombinant Human Casein Kinase 2 beta, Active \ 228-10240-1
Casein Kinase 1 delta ELISA & Assay Kits
CSNK1A1 (CK1 α 1) Recombinant Human Protein
Universal Nutrition Casein Pro - Acacia World
How much protein is in Casein Protein Powder?
Casein Protein Powder - The Slow Digesting Protein
Micelar Casein 2000g - Extrifit | BestBody.sk
FAM83H抗体|Abcam中国|Anti-FAM83H抗体(ab121816)
Centaurin, alpha 1
"Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1-3): 167-71. doi:10.1016/s0014-5793( ... Casein kinase 1, alpha 1 Nucleolin, P110α, PRKCI, Protein kinase D1, and Protein kinase Mζ. Model organisms have been used in ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ...
ERF (gene)
Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners ... "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation". ...
PPP1R14A
Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ... "Association of CPI-17 with protein kinase C and casein kinase I". Biochem. Biophys. Res. Commun. 316 (1): 39-47. doi:10.1016/j. ... Multiple kinases are identified to phosphorylate CPI-17, such as PKC, ROCK, PKN, ZIPK, ILK, and PAK. Agonist stimulation of ... Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 ...
SYT9
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological ... "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological ...
AP3B1
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... Kim YM, Barak LS, Caron MG, Benovic JL (May 2002). "Regulation of arrestin-3 phosphorylation by casein kinase II". The Journal ...
HMGB2
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in ...
CHKA
Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ... Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat ... Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. The major pathway for the biosynthesis of ... 1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4 ...
AP3B2
"The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform". ...
List of MeSH codes (D08)
... casein kinase i MeSH D08.811.913.696.620.682.700.140.300.100 - casein kinase ialpha MeSH D08.811.913.696.620.682.700.140. ... map kinase kinase kinase 1 MeSH D08.811.913.696.620.682.700.559.200 - map kinase kinase kinase 2 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 - map kinase kinase kinase 4 MeSH D08.811.913.696.620.682. ... casein kinase idelta MeSH D08.811.913.696.620.682.700.140.300.300 - casein kinase iepsilon MeSH D08.811.913.696.620.682.700.140 ...
List of MeSH codes (D12.776.476)
... casein kinase ialpha MeSH D12.776.476.150.300.200 - casein kinase idelta MeSH D12.776.476.150.300.300 - casein kinase iepsilon ... cdc2 protein kinase MeSH D12.776.476.250.067.500 - cdc28 protein kinase, s cerevisiae MeSH D12.776.476.250.067.875 - cyclin- ... dependent kinase 5 MeSH D12.776.476.250.067.900 - cyclin-dependent kinase 9 MeSH D12.776.476.250.580.500 - cdc2 protein kinase ... mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 - mitogen-activated protein kinase 3 MeSH D12.776.476.450. ...
List of MeSH codes (D12.644)
... casein kinase i MeSH D12.644.360.150.300.100 - casein kinase ialpha MeSH D12.644.360.150.300.200 - casein kinase idelta MeSH ... map kinase kinase kinase 1 MeSH D12.644.360.400.200 - map kinase kinase kinase 2 MeSH D12.644.360.400.300 - map kinase kinase ... kinase 3 MeSH D12.644.360.400.400 - map kinase kinase kinase 4 MeSH D12.644.360.400.500 - map kinase kinase kinase 5 MeSH ... map kinase kinase 1 MeSH D12.644.360.440.200 - map kinase kinase 2 MeSH D12.644.360.440.300 - map kinase kinase 3 MeSH D12.644. ...
Casein kinase 1, alpha 1
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. Casein kinase 1, alpha 1 has been ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024576 ...
Casein Kinase Ialpha
Summary Report | CureHunter
In DROSOPHILA casein kinase Ialpha has been in regulation of Hedghog and Wingless signaling pathways. Multiple isoforms of ... casein kinase Ialpha exist and are due ALTERNATIVE SPLICING. ... A casein kinase I isoenzyme that plays a role in intracellular ... Protein Kinases: 9706*Protein-Serine-Threonine Kinases: 1353*Casein Kinases: 99*Casein Kinase I: 50*Casein Kinase Ialpha ... Casein Kinase Ialpha. Subscribe to New Research on Casein Kinase Ialpha A casein kinase I isoenzyme that plays a role in ...
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. - PubMed - NCBI
This "priming" kinase is casein kinase Ialpha (CKIalpha). Depletion of CKIalpha inhibits beta-catenin phosphorylation and ... Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.. Liu C1, Li Y, Semenov M, Han C, Baeg GH, Tan Y ... which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and ... adnomatous polyposis coli (APC). Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin ...
Effect of casein and inulin addition on physico-chemical characteristics of low fat camel dairy cream.
The effect of the addition of the camel casein fraction on some physico-chemical properties of low fat camel milk cream was ... Casein Kinase Ialpha. A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the CELL ... Casein Kinase I. A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kD. ... Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I ...
Casein kinase 1, alpha 1 - Wikipedia
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. Casein kinase 1, alpha 1 has been ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024576 ...
Centaurin, alpha 1 - Wikipedia
"Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1-3): 167-71. doi:10.1016/s0014-5793( ... Casein kinase 1, alpha 1 Nucleolin, P110α, PRKCI, Protein kinase D1, and Protein kinase Mζ. Model organisms have been used in ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ...
Active Human Casein Kinase 1, alpha 1 (CSNK1A1) Protein (GST tag), Recombinant | ABIN2003196
Recombinant Casein Kinase 1, alpha 1 (CSNK1A1) Protein (GST tag). Spezies: Human. Quelle: Baculovirus infected Insect Cells. ... casein kinase 1 alpha 1 L homeolog * Casein kinase Ialpha * CSNK1A1 * KRT1 ... Casein Kinase 1, alpha 1 (CSNK1A1) (AA 1-337), (full length) (Active) protein (GST tag). Details zu Produkt Nr. ABIN2003196, ... Casein Kinase 1, alpha 1 (CSNK1A1) Synonyme für dieses Antigen anzeigen * CK1 ...
ERF (gene) - wikidoc
Serine 235 Is the Primary NS5A Hyperphosphorylation Site Responsible for Hepatitis C Virus Replication | Journal of Virology
Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity ... Casein kinase Iα was responsible for S235 and S238 phosphorylation.The lipid kinase PI4KIIIα (23, 31-34) and the protein kinase ... Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-alpha in infectious virus production. J ... Phosphate groups as substrate determinants for casein kinase I action. J Biol Chem265:14264-14269. ...
IMP: Integrative Multi-species Prediction
Adaptor protein complexes and intracellular transport | Bioscience Reports
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. - PubMed - NCBI
Casein Kinase I/genetics. *Casein Kinase I/metabolism. *Casein Kinase Ialpha/metabolism* ... family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase ... Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.. Thorne CA1, Hanson AJ, Schneider J, Tahinci ... Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α ...
IMP: Integrative Multi-species Prediction
DeCS
Casein Kinase Ialpha Entry term(s):. Casein Kinase I alpha. Casein Kinase IalphaL. Casein Kinase IalphaLS. Casein Kinase ... Casein Kinase Ialpha - Preferred Concept UI. M0072784. Scope note. A casein kinase I isoenzyme that plays a role in ... A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL ... Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING. ...
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
This priming kinase is casein kinase Ialpha (CKIalpha). Depletion of CKIalpha inhibits beta-catenin phosphorylation and ... which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and ... adnomatous polyposis coli (APC). Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin ... This "priming" kinase is casein kinase Ialpha (CKIalpha). Depletion of CKIalpha inhibits beta-catenin phosphorylation and ...
Robust hepatitis C virus infection in vitro | PNAS
Casein Kinase I | Profiles RNS
Casein Kinase I. *Casein Kinase Ialpha. *Casein Kinase Idelta. *Casein Kinase Iepsilon ... Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I ... "Casein Kinase I" by people in this website by year, and whether "Casein Kinase I" was a major or minor topic of these ... "Casein Kinase I" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
Sex-chromosome anaphase movements in crane-fly spermatocytes are coordinated: ultraviolet microbeam irradiation of one...
Pharmacological evidence for a role for cyclic AMP signalling in Dictyostelium discoideum slug behaviour | Journal of Cell...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.476.150.299 Casein Kinase Ialpha D12.644.360.150.300.100 D5.500.117.750.100 D12.776.476.150.300.100 D12.776.476.81. ... D12.776.476.150.299.300 Casein Kinase II D12.644.360.150.600 Casein Kinases D12.644.360.150 CD4 Lymphocyte Count E1.450.375.107 ... D2.33.755.624.698.207 Casein Kinase I D12.644.360.150.300 D5.500.117.750 D12.776.476.150.300 D12.776.476.81.750 ... D12.776.476.150.299.200 Casein Kinase Iepsilon D12.644.360.150.300.300 D5.500.117.750.300 D12.776.476.150.300.300 D12.776. ...
Casein kinase
... in the largest biology dictionary online. Free learning resources for students covering all major areas of ... gbf1 kinase, t-antigen kinase, orb5 gene product, protein kinase ck1, protein kinase cki, casein kinase ialpha, casein kinase ... Synonym: casein kinase i, casein kinase ts, casein g kinase, kappa casein kinase, g-box binding factor 1 kinase, ... casein kinase igamma, yck1 protein, yck2 protein, yck3 gene product, casein kinase 1 epsilon, casein kinase 1 delta ...
DeCS 2005 - New terms
Casein Kinase II Caseína Quinase II Quinasa de la Caseína II Casein Kinase Ialpha Caseína Quinase Ialfa Quinasa Ialpha de la ... Casein Kinase Iepsilon Caseína Quinase Iépsilon Quinasa Iépsilon de la Caseína Casein Kinases Caseína Quinases Quinasas de la ... MAP Kinase Kinase Kinase 1 MAP Quinase Quinase Quinase 1 Quinasa 1 de Qinasa de Quinasa MAP ... MAP Kinase Kinase Kinase 2 MAP Quinase Quinase Quinase 2 Quinasa 2 de Qinasa de Quinasa MAP ...
Labnodes - The Vanderbilt Research Network
Connections to Casein Kinase Ialpha are shown below. Double-click or tap a node for more information. ... If you expected more, please view all publication matches for Casein Kinase Ialpha. ... Casein Kinase 1α as a Regulator of Wnt-Driven Cancer.. Shen C, Nayak A, Melendez RA, Wynn DT, Jackson J, Lee E, Ahmed Y, ... Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.. Thorne CA, Hanson AJ, Schneider J, Tahinci ...
Protein4
- Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications. (wikipedia.org)
- Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C. The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. (umassmed.edu)
- Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. (yale.edu)
- ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). (yale.edu)
Isoforms2
- Multiple isoforms of casein kinase Ialpha exist and are due ALTERNATIVE SPLICING. (curehunter.com)
- Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING. (bvsalud.org)
CSNK1A11
- Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. (wikipedia.org)
CKIalpha1
- This "priming" kinase is casein kinase Ialpha (CKIalpha). (nih.gov)
Enzyme1
- A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kD. (bioportfolio.com)
MESH1
- Casein Kinase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Centaurin1
- Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1 and AXIN1. (wikipedia.org)
Phosphorylation4
- Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (nih.gov)
- beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). (nih.gov)
- Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin precedes and is required for subsequent GSK-3 phosphorylation of beta-catenin. (nih.gov)
- S238 is likely phosphorylated by casein kinase Iα, which requires a priming phosphorylation at S235. (asm.org)
Regulation1
- In DROSOPHILA casein kinase Ialpha has been in regulation of Hedghog and Wingless signaling pathways. (curehunter.com)
Activity3
- Modification of IgE binding to α-casein by proteolytic activity of Enterococcus faecium isolated from Iranian camel milk samples. (bioportfolio.com)
- The specific activity was determined to be 30 nmol/min/mg using casein as substrate. (antikoerper-online.de)
- We show pyrvinium binds all casein kinase 1 (CK1) family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase activity. (nih.gov)
Separate2
- Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. (umassmed.edu)
- there is a separate record for casein kinase II registry number: EC 2.7.1. (biologyonline.com)
Shown1
- Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION. (umassmed.edu)
Effect2
- Effect of casein and inulin addition on physico-chemical characteristics of low fat camel dairy cream. (bioportfolio.com)
- Effect of high intensity ultrasound pretreatment on functional and structural properties of micellar casein concentrates. (bioportfolio.com)
Role1
- A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the CELL CYCLE, membrane trafficking, and RNA processing. (curehunter.com)