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Casein Kinase ICasein KinasesCasein Kinase IICasein Kinase IepsilonCaseinsProtein KinasesCasein Kinase IdeltaCasein Kinase IalphaPhosphorylationProtein-Serine-Threonine KinasesAmino Acid SequenceMolecular Sequence DataProtein Kinase InhibitorsSubstrate SpecificityPeptide MappingPhosphatidylinositol 3-KinasesSerineCalcium-Calmodulin-Dependent Protein KinasesCyclic GMP-Dependent Protein Kinase Type IPhosphopeptidesIsoenzymesMAP Kinase Signaling SystemPhosphoproteinsDopamine and cAMP-Regulated Phosphoprotein 32Period Circadian ProteinsKineticsCyclic GMP-Dependent Protein KinasesBase SequenceRecombinant ProteinsIsoquinolinesSequence Homology, Amino AcidThreonineSignal TransductionProtein BindingRabbitsAxin ProteinProtein Kinase CCattleCyclic AMP-Dependent Protein KinasesPhosphoprotein PhosphatasesChromatography, AgaroseBinding Sitessrc-Family KinasesCloning, MolecularElectrophoresis, Polyacrylamide GelMutationSaccharomyces cerevisiaeCell LineSaccharomyces cerevisiae ProteinsMolecular Weightp38 Mitogen-Activated Protein KinasesMutagenesis, Site-DirectedCircadian RhythmWnt ProteinsEnzyme ActivationProto-Oncogene ProteinsMitogen-Activated Protein Kinase 1Glycogen Synthase Kinase 3CDC2 Protein KinaseAdaptor Proteins, Signal TransducingNuclear ProteinsJNK Mitogen-Activated Protein KinasesDichlororibofuranosylbenzimidazoleTranscription FactorsProtein Processing, Post-Translationalp21-Activated KinasesProtein-Tyrosine KinasesMitogen-Activated Protein Kinase KinasesCyclin-Dependent KinasesHeparinCell MembraneMitogen-Activated Protein Kinase 3PhosphoserineGlycogen SynthaseRestriction MappingDNA PrimersRecombinant Fusion ProteinsChromatography, AffinityCreatine KinaseTransfectionMAP Kinase Kinase KinasesGenes, FungalBlotting, WesternProtein Structure, TertiaryZebrafish ProteinseIF-2 KinaseCyclic AMPCell NucleusRibosomal Protein S6 KinasesPrecipitin TestsPhosvitinPhosphothreoninePyruvate KinaseTestisMitogen-Activated Protein KinasesHeLa CellsCyclin-Dependent Kinase 5MAP Kinase Kinase 1Enzyme InhibitorsAdenosine Triphosphate
Casein Kinase I
A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.
Casein Kinases
A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.
Casein Kinase II
A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.
Casein Kinase Iepsilon
A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM.
Caseins
A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.
Protein Kinases
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
Casein Kinase Idelta
A casein kinase I isoenzyme that plays a regulatory role in a variety of cellular functions including vesicular transport, CHROMOSOME SEGREGATION; CYTOKINESIS, developmental processes, and the CIRCADIAN RHYTHM.
Casein Kinase Ialpha
A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING.
Phosphorylation
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Protein-Serine-Threonine Kinases
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Protein Kinase Inhibitors
Agents that inhibit PROTEIN KINASES.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Peptide Mapping
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Phosphatidylinositol 3-Kinases
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Serine
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Calcium-Calmodulin-Dependent Protein Kinases
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
Cyclic GMP-Dependent Protein Kinase Type I
A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA.
Phosphopeptides
Isoenzymes
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
MAP Kinase Signaling System
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Phosphoproteins
Dopamine and cAMP-Regulated Phosphoprotein 32
A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.
Period Circadian Proteins
Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.
Kinetics
The rate dynamics in chemical or physical systems.
Cyclic GMP-Dependent Protein Kinases
A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Isoquinolines
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Threonine
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Axin Protein
A scaffolding protein that is a critical component of the axin signaling complex which binds to ADENOMATOUS POLYPOSIS COLI PROTEIN; GLYCOGEN SYNTHASE KINASE 3; and CASEIN KINASE I.
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Cyclic AMP-Dependent Protein Kinases
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
Phosphoprotein Phosphatases
A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)
Chromatography, Agarose
A method of gel filtration chromatography using agarose, the non-ionic component of agar, for the separation of compounds with molecular weights up to several million.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
src-Family Kinases
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Saccharomyces cerevisiae
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Saccharomyces cerevisiae Proteins
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Molecular Weight
The sum of the weight of all the atoms in a molecule.
p38 Mitogen-Activated Protein Kinases
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Mutagenesis, Site-Directed
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Circadian Rhythm
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Wnt Proteins
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Enzyme Activation
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Mitogen-Activated Protein Kinase 1
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Glycogen Synthase Kinase 3
A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
CDC2 Protein Kinase
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Nuclear Proteins
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
JNK Mitogen-Activated Protein Kinases
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
Dichlororibofuranosylbenzimidazole
An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
p21-Activated Kinases
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
Protein-Tyrosine Kinases
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
Mitogen-Activated Protein Kinase Kinases
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Cyclin-Dependent Kinases
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Cell Membrane
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Mitogen-Activated Protein Kinase 3
A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.
Phosphoserine
The phosphoric acid ester of serine.
Glycogen Synthase
An enzyme that catalyzes the transfer of D-glucose from UDPglucose into 1,4-alpha-D-glucosyl chains. EC 2.4.1.11.
Restriction Mapping
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
DNA Primers
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Recombinant Fusion Proteins
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Chromatography, Affinity
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
MAP Kinase Kinase Kinases
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Genes, Fungal
The functional hereditary units of FUNGI.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Zebrafish Proteins
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
eIF-2 Kinase
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Cyclic AMP
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Ribosomal Protein S6 Kinases
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.
Precipitin Tests
Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.
Phosvitin
An egg yolk phosphoglycoprotein which contains about 90% of the yolk protein phosphorus. It is synthesized in the liver of the hen and transferred to the developing oocyte, where it is bound to lipoproteins within the yolk granules.
Phosphothreonine
The phosphoric acid ester of threonine. Used as an identifier in the analysis of peptides, proteins, and enzymes.
Pyruvate Kinase
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Testis
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
Mitogen-Activated Protein Kinases
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
HeLa Cells
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Cyclin-Dependent Kinase 5
A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation.
MAP Kinase Kinase 1
An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Adenosine Triphosphate
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Intracellular Signaling Peptides and Proteins
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Receptor Protein-Tyrosine Kinases
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
rho-Associated Kinases
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Thymidine Kinase
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
I-kappa B Kinase
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
Macromolecular Substances
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Calmodulin
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
Extracellular Signal-Regulated MAP Kinases
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
MAP Kinase Kinase 4
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
1-Phosphatidylinositol 4-Kinase
An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
Cytosol
Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.
Phosphotransferases (Alcohol Group Acceptor)
A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.
CDC2-CDC28 Kinases
A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE; S CEREVISIAE; and the CDC2 PROTEIN KINASE found in mammalian species.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
DNA, Complementary
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Aurora Kinases
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
Myosin-Light-Chain Kinase
An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
Immunoblotting
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
Protein Kinase C-delta
A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.
Protein Kinase C-alpha
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Glycogen Synthase Kinases
A class of protein-serine-threonine kinases that was originally found as one of the three types of kinases that phosphorylate GLYCOGEN SYNTHASE. Glycogen synthase kinases along with CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASES and CYCLIC AMP-DEPENDENT PROTEIN KINASES regulate glycogen synthase activity.
Tyrosine
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Proto-Oncogene Proteins c-akt
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Gene Expression Regulation, Enzymologic
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Carrier Proteins
Transport proteins that carry specific substances in the blood or across cell membranes.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Diacylglycerol Kinase
An enzyme of the transferase class that uses ATP to catalyze the phosphorylation of diacylglycerol to a phosphatidate. EC 2.7.1.107.
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Cytoplasm
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Phloroglucinol
A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Chromatography, Ion Exchange
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
Calcium-Calmodulin-Dependent Protein Kinase Type 4
A monomeric calcium-calmodulin-dependent protein kinase subtype that is primarily expressed in neuronal tissues; T-LYMPHOCYTES and TESTIS. The activity of this enzyme is regulated by its phosphorylation by CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE.
Cell Division
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Cyclic GMP
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Reticulocytes
Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.
Protein Transport
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Dietary Proteins
Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.
Focal Adhesion Kinase 1
A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Polylysine
A peptide which is a homopolymer of lysine.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

The Yck2 yeast casein kinase 1 isoform shows cell cycle-specific localization to sites of polarized growth and is required for proper septin organization. (1/189)

Casein kinase 1 protein kinases are ubiquitous and abundant Ser/Thr-specific protein kinases with activity on acidic substrates. In yeast, the products of the redundant YCK1 and YCK2 genes are together essential for cell viability. Mutants deficient for these proteins display defects in cellular morphogenesis, cytokinesis, and endocytosis. Yck1p and Yck2p are peripheral plasma membrane proteins, and we report here that the localization of Yck2p within the membrane is dynamic through the cell cycle. Using a functional green fluorescent protein (GFP) fusion, we have observed that Yck2p is concentrated at sites of polarized growth during bud morphogenesis. At cytokinesis, GFP-Yck2p becomes associated with a ring at the bud neck and then appears as a patch of fluorescence, apparently coincident with the dividing membranes. The bud neck association of Yck2p at cytokinesis does not require an intact septin ring, and septin assembly is altered in a Yck-deficient mutant. The sites of GFP-Yck2p concentration and the defects observed for Yck-deficient cells together suggest that Yck plays distinct roles in morphogenesis and cytokinesis that are effected by differential localization.  (+info)

Casein kinase I-dependent phosphorylation within a PEST sequence and ubiquitination at nearby lysines signal endocytosis of yeast uracil permease. (2/189)

Uracil uptake by Saccharomyces cerevisiae is mediated by the FUR4-encoded uracil permease. The modification of uracil permease by phosphorylation at the plasma membrane is a key mechanism for regulating endocytosis of this protein. This modification in turn facilitates its ubiquitination and internalization. Following endocytosis, the permease is targeted to the lysosome/vacuole for proteolysis. We have previously shown that uracil permease is phosphorylated at several serine residues within a well characterized N-terminal PEST sequence. In this report, we provide evidence that lysine residues 38 and 41, adjacent to the PEST sequence, are the target sites for ubiquitination of the permease. Conservative substitutions at both Lys(38) and Lys(41) give variant permeases that are phosphorylated but fail to internalize. The PEST sequence contains potential phosphorylation sites conforming to the consensus sequences for casein kinase 1. Casein kinase 1 (CK1) protein kinases, encoded by the redundant YCKI and YCK2 genes, are located at the plasma membrane. Either alone supports growth, but loss of function of both is lethal. Here, we show that in CK1-deficient cells, the permease is poorly phosphorylated and poorly ubiquitinated. Moreover, CK1 overproduction rescued the defective endocytosis of a mutant permease in which the serine phosphoacceptors were replaced by threonine (a less effective phosphoacceptor), which suggests that Yck activity may play a direct role in phosphorylating the permease. Permease internalization was not greatly affected in CK1-deficient cells, despite the low level of ubiquitination of the protein. This may be due to CK1 having a second counteracting role in endocytosis as shown by the higher turnover of variant permeases with unphosphorylatable versions of the PEST sequence.  (+info)

Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. (3/189)

In the Drosophila visual system, photoreceptor neurons (R cells) extend axons towards glial cells located at the posterior edge of the eye disc. In gilgamesh (gish) mutants, glial cells invade anterior regions of the eye disc prior to R cell differentiation and R cell axons extend anteriorly along these cells. gish encodes casein kinase Igamma. gish, sine oculis, eyeless, and hedgehog (hh) act in the posterior region of the eye disc to prevent precocious glial cell migration. Targeted expression of Hh in this region rescues the gish phenotype, though the glial cells do not require the canonical Hh signaling pathway to respond. We propose that the spatiotemporal control of glial cell migration plays a critical role in determining the directionality of R cell axon outgrowth.  (+info)

Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway function. (4/189)

The S. cerevisiae Yck2 protein is a plasma membrane-associated member of the casein kinase 1 protein kinase family that, with its homolog Yck1p, is required for bud morphogenesis, cytokinesis, endocytosis and other cellular processes. Membrane localization of Yckp is critical for its function, since soluble mutants do not provide sufficient biological activity to sustain normal growth. Yck2p has neither a predicted signal sequence nor obvious transmembrane domain to achieve its plasma membrane localization, but has a C-terminal -Cys-Cys sequence that is likely to be palmitoylated. We demonstrate here that Yck2p is targeted through association with vesicular intermediates of the classical secretory pathway. Yck2p lacking C-terminal Cys residues fails to associate with any membrane, whereas substitution of these residues with a farnesyl transferase signal sequence allows sec-dependent plasma membrane targeting and biological function, suggesting that modification is required for interaction with early secretory membranes but that targeting does not require a particular modification. Deletion analysis within the 185 residue C-terminus indicates that the final 28 residues are critical for membrane association, and additional sequences just upstream are required for proper plasma membrane targeting.  (+info)

Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I. (5/189)

Calcineurin is a Ca2+/calmodulin-regulated protein phosphatase required for Saccharomyces cerevisiae to respond to a variety of environmental stresses. Calcineurin promotes cell survival during stress by dephosphorylating and activating the Zn-finger transcription factor Crz1p/Tcn1p. Using a high-throughput assay, we screened 119 yeast kinases for their ability to phosphorylate Crz1p in vitro and identified the casein kinase I homolog Hrr25p. Here we show that Hrr25p negatively regulates Crz1p activity and nuclear localization in vivo. Hrr25p binds to and phosphorylates Crz1p in vitro and in vivo. Overexpression of Hrr25p decreases Crz1p-dependent transcription and antagonizes its Ca2+-induced nuclear accumulation. In the absence of Hrr25p, activation of Crz1p by Ca2+/calcineurin is potentiated. These findings represent the first identification of a negative regulator for Crz1p, and establish a novel physiological role for Hrr25p in antagonizing calcineurin signaling.  (+info)

The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXPhi adaptin sorting signal. (6/189)

Our previous work found the two yeast plasma membrane-localized casein kinases Yck1p and Yck2p to be palmitoylated on C-terminal Cys-Cys sequences by the palmitoyl transferase Akr1p. The present work examines a third casein kinase, Yck3p, which ends with the C-terminal sequence Cys-Cys-Cys-Cys-Phe-Cys-Cys-Cys. Yck3p is palmitoylated and localized to the vacuolar membrane. While the C-terminal cysteines are required for this palmitoylation, Akr1p is not. Palmitoylation requires the C-terminal Yck3p residues 463-524, whereas information for vacuolar sorting maps to the 409-462 interval. Vacuolar sorting is disrupted in cis through deletion of the 409-462 sequences and in trans through mutation of the AP-3 adaptin complex; both cis- and trans-mutations result in Yck3p missorting to the plasma membrane. This missorted Yck3p restores 37 degrees C viability to yck1Delta yck2-ts cells. yck1Delta yck2-ts suppressor mutations isolated within the YCK3 gene identify the Yck3p vacuolar sorting signal-the tetrapeptide YDSI, a perfect fit to the YXXPhi adaptin-binding consensus. Although YXXPhi signals have a well-appreciated role in the adaptin-mediated sorting of mammalian cells, this is the first signal of this class to be identified in yeast.  (+info)

D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. (7/189)

The protein kinase CK1 phosphorylates serine residues that are located close to another phosphoserine in the consensus pSer-Xaa-Xaa-Ser. This specificity generates regions in its target proteins containing two or more neighbouring phosphoserine residues, termed here multisite phosphorylation domains (MPDs). In this paper, we demonstrate that D4476 is a potent and rather selective inhibitor of CK1 in vitro and in cells. In H4IIE hepatoma cells, D4476 specifically inhibits the phosphorylation of endogenous forkhead box transcription factor O1a (FOXO1a) on Ser322 and Ser325 within its MPD, without affecting the phosphorylation of other sites. Our results indicate that these residues are targeted by CK1 in vivo and that the CK1-mediated phosphorylation of the MPD is required for accelerated nuclear exclusion of FOXO1a in response to IGF-1 and insulin. D4476 is much more potent and specific than IC261 or CKI-7, and is therefore the most useful CK1 inhibitor currently available for identifying physiological substrates of CK1.  (+info)

Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. (8/189)

The yeast Saccharomyces cerevisiae senses glucose through two transmembrane glucose sensors, Snf3 and Rgt2. Extracellular glucose causes these sensors to generate an intracellular signal that induces expression of HXT genes encoding glucose transporters by inhibiting the function of Rgt1, a transcriptional repressor of HXT genes. We present the following evidence that suggests that the glucose sensors are coupled to the membrane-associated protein kinase casein kinase I (Yck1). (i) Overexpression of Yck1 leads to constitutive HXT1 expression; (ii) Yck1 (or its paralogue Yck2) is required for glucose induction of HXT1 expression; (iii) Yck1 interacts with the Rgt2 glucose sensor; and (iv) attaching the C-terminal cytoplasmic tail of Rgt2 to Yck1 results in a constitutive glucose signal. The likely targets of Yck1 in this signal transduction pathway are Mth1 and Std1, which bind to and regulate function of the Rgt1 transcription factor and bind to the C-terminal cytoplasmic domain of glucose sensors. Potential casein kinase I phosphorylation sites in Mth1 and Std1 are required for normal glucose regulation of HXT1 expression, and Yck1 catalyzes phosphorylation of Mth1 and Std1 in vitro. These results support a model of glucose signaling in which glucose binding to the glucose sensors causes them to activate Yck1 in the cell membrane, which then phosphorylates Mth1 and Std1 bound to the cytoplasmic face of the glucose sensors, triggering their degradation and leading to the derepression of HXT gene expression. Our results add nutrient sensing to the growing list of processes in which casein kinase I is involved.  (+info)

Arabidopsis root morphology and its correlation with cortical microtubule rearrangements caused by specific inhibition of...Arabidopsis root morphology and its correlation with cortical microtubule rearrangements caused by specific inhibition of...
1. Gross, S.D. and Anderson, R.A., Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family, Cell Signal., 1998, vol. 10, pp. 699 711.. 2. Schittek, B. and Sinnberg, T., Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis, Mol. Cancer, 2014, vol. 13, no. 231. https://doi.org/10.1186/1476-4598-13-231 3. Robinson, L.C., Menold, M.M., Garrett, S., and Culbertson, M.R., Casein kinase I-like protein kinases encoded by YCK1 and YCK2 are required for yeast morphogenesis, Mol. Cell Biol., 1993, vol. 13, pp. 2870 2881.. 4. Kloss, B., Price, J.L., Saez, L., Blau, J., Rothenfluh, A., Wesley, C.S., and Young, M.W., The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Ie, Cell, 1998, vol. 94, pp. 97 107.. 5. Peters, J.M., McKay, R.M., McKay, J.P., and Graff, J.M., Casein kinase I transduces Wnt signals, Nature, 1999, vol. 401, pp. 345 350.. 6. Dhillon, N. and Hoekstra, M.F., Characterization of ...
http://www.cytgen.com/en/2019/_3-14N6V53.htm
The Epic of Gilgamesh Themes - eNotes.comThe Epic of Gilgamesh Themes - eNotes.com
Discussion of themes and motifs in The Epic of Gilgamesh. eNotes critical analyses help you gain a deeper understanding of The Epic of Gilgamesh so you can excel on your essay or test.
https://www.enotes.com/topics/epic-gilgamesh/themes
Ebook The Epic of Gilgamesh | Pdf/ePub downloads free
Ebook Download The Epic Of Gilgamesh, Find, Download, Read Books in Free Pdf / ePubThe Epic Of Gilgamesh Please Register your account, Easy and Fast!
https://mangacurmudgeon.com/the-epic-of-gilgamesh/
Electronic music | Elliott Grabill
Enkidu, for baritone saxophone and live electronics, was written for Tae Ho Hwang, and premiered at the Electroacoustic Barndance in February, 2018. My goal was to create a longer solo electroacoustic piece whose development is driven by motivic material. The design of the electronics of this movement resembles a telescope, beginning with little except a bit of reverb, but incrementally expanding the palate to include delay, looping, pitch shift, and the flanger.. Enkidu is the companion of King Gilgamesh of Uruk in the ancient, four thousand year old Epic of Gilgamesh. Enkidu and Gilgamesh become friends, and could be seen as two archetypes of humanity. Gilgamesh represents the city, civilization, and humanitys advancement; Enkidu represents the primative, nature, and humans origin. The third movement of the piece mirrors the emotions explored in the second half of the epic, where Gilgamesh struggles to come to grip with his own mortality after Enkidus death. The movement evokes scenes of ...
http://elliottgrabill.com/category/electronic-music
New Saccharomyces Sequences 05/06/00New Saccharomyces Sequences 05/06/00
Updated DNA Sequences ===================== SCE9781 U18916 L11119 L11120 U00092 U75972 68301bp DNA PLN 01-MAY-2000 Saccharomyces cerevisiae chromosome V cosmids 9781, 8198, 9115, 9981, and lambda clones 3955 and 6052. PAK1 (DNA polymerase alphaRSP5 (suppressor of mutations in SPT3); FLO8; Flo8p: transcriptional activator of FLO1; YER109c; Yer109p; KAP123; Kap123p: Karyopherin beta 4; SWI4; Swi4p: transcription factor; USS1; Uss1p: core protein of small nuclear ribonucleoprotein; YER113C; Yer113cp; BOI2; Boi2p; SPR6; Spr6p; YER116C; Yer116cp; RPL17B; Rpl17bp: Ribosomal protein, large subunit; SSU81; Ssu81p: Transmembrane osmosensor; YER119C; Yer119cp; YER119C-A; Yer119c-ap; SCS2; Scs2p; YER121W; Yer121wp; GLO3; Glo3p; YCK3; Yck3p: Plasma membrane-bound casein kinase I homolog; YER124C; Yer124cp; RSP5; Rsp5p; YER126C; Yer126cp; YER127W; Yer127wp; YER128W; Yer128wp; PAK1; Pak1p: DNA polymerase alpha suppressing protein kinase; YER130C; Yer130cp; RPS26B; Rps26bp; SNR4; YER132C; Yer132cp; GLC7; ...
http://bio.net/bionet/mm/yeast/2000-May/009388.html
RCSB PDB - Protein Feature View - Casein kinase I homolog 1 - P40233 (CKI1 SCHPO)RCSB PDB - Protein Feature View - Casein kinase I homolog 1 - P40233 (CKI1 SCHPO)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/protein/P40233
p.p1 of death was not his only motivator, but -Good Teaching Practice
p.p1 {margin: 0.0px 0.0px 10.0px 0.0px; text-indent: 36.0px; font: 11.0px Times New Roman; color: #000000; -webkit-text-stroke: #000000} p.p2 {margin: 0.0px 0.0px 10.0px 0.0px; text-indent: 36.0px; font: 11.0px Times New Roman; color: #000000; -webkit-text-stroke: #000000; min-height: 12.0px} span.s1 {font-kerning: none} Gilgamesh departed Uruk and went to seek out Ziusundra, a sage who had been alive since leading many animals into an ark before a deluge that murdered everyone on earth came. He was said to be the only human being who had survived the massive storm. He, for decades, wandered all through the deserts. The epic describes his movement during the journey as groveling along pathetically, and though a demigod; he was tasked with the same mission of all mere human beings, overcoming death (Kline, 2016). Klines statement highlights the fundamental desire of those humans who are omnipotent leaders, the desire for that power to live perpetually. He progressed in his journey with ...
https://careersuccessions.com/p-p1-of-death-was-not-his-only-motivator-but/
Download The Future Of Representative DemocracyDownload The Future Of Representative Democracy
This download the future of representative migrates both the free two years of this successful screen, and the woman in pdf. 34; and is the downloads doings. The download the of Gilgamesh s the earliest using RIEs of physical survey.
http://templartitan.com/intel-portal2/book/download-the-future-of-representative-democracy.htm
HEART[❤]SIGH -> IN THE DEVILS HANDS--...
humans were amazingly and utterly foolish. hed known this from the day he was created, born out of a thick black tarpit and given sentience and control to far surpass any mortal on that rolling little dirt ball in space. he lived and survived, thrived even, in the void of his dimension, a perfect predator and thing to be feared. as it was, gilgamesh hadnt encountered mortals other than through the occasional mirror-glimpse into their world. he didnt go there, mostly because hed never been fully summoned. some parts of him went, a conscious thought here and a breath of air there, but for the most part, hed always been tethered to his own dark void long enough to be sent back when he was no longer wanted. when humans playing with opening portals between worlds came to speak to spirits, he had an easy time fitting in as an unassuming ghoul, but that was only a small part of him. hed never had enough energy brought to him, given to him, to be able to stay for long, or to show his corporeal ...
http://heartsigh.net/index.php?showtopic=3269
Fate/kaleid liner PRISMA ILLYA 2wei Herz! #009: Kintaro Oe Went on to Have a VERY Strange Life - Reverse ThievesFate/kaleid liner PRISMA ILLYA 2wei Herz! #009: Kintaro Oe Went on to Have a VERY Strange Life - Reverse Thieves
If I were smart this posts title would continue to talk about Gilgamesh being naked as opposed to making references to a mostly forgotten saucy 90s OVA. But that is why this blog will always remain at its current popularity as it is as opposed to getting some sort of real attention. Im sorry Kate.…
https://reversethieves.com/2015/09/19/fatekaleid-liner-prisma-illya-2wei-herz-009-kintaro-oe-went-on-to-have-a-very-strange-life/
Casein kinase I isoform epsilonCasein kinase I isoform epsilon
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014 ...
https://pharos.nih.gov/idg/targets/P49674
Keys to unlock the doors of Milky Way Mythology
Without going now into the relevant comparative material it should be stressed that in those cases where kings are sitting in a wagon (Greek hamaxa), i.e., a four-wheeled truck, it is most of the time Charles Wain.. Alexander was a true myth builder, or rather, a true myth attracting magnet. He had a gift for attracting to his fabulous personality the manifold tradition that, once, had been coined for Gilgamesh.. But the time is not yet ripe either for Alexander or for Gilgamesh, nor for further statements about deities or heroes who could pull out pins, plugs and pillars. The next concern is with the decisive features of the mythical landscape and their possible localization, or their fixation in time. It is essential to know where and when the first whirlpool came into being once Grotte, Amlodhis Mill, had been destroyed. This is, however, a misleading expression because our terminology is still much too imprecise. It would be better to say the first exit from, or entrance to, the ...
http://native-science.net/MilkyWay.Mythology.Keys.htm
ED] Logs: September 2007ED] Logs: September 2007
Observations about obsessional love and compulsive sexual behaviors are not new. Since human beings began to express themselves on granite walls and clay scrolls, there has been a fascination with sexuality. Secular and religious literature, oral history, art and music were all replete with both overt and oblique references to the power sex holds. About 4,000 years ago, the Sumarians wrote about the sexual conquests of the warrior Gilgamesh in The Epic of Gilgamesh which describes his behavior and reputation: His lust leaves no virgin to her lover, neither the warriors daughter nor the wife of the nobleman. Forty centuries later the Internet burst upon the world and has given us yet another outlet for the expression of sexuality. Its potential seems infinite, frightening and wondrous all at the same time.. In May 1997, theWall Street Journal ran a story about a stripper, Danni Ashe, who was able to use her business skills to market sexually explicit images of herself and other models on the ...
http://edlogs.blogspot.com/2007/09/
Copy, Paste | Greenville University PapyrusCopy, Paste | Greenville University Papyrus
There are many creation stories from the Ancient Near East (ANE). You have some that begin ex nihilo, some out of chaos and some that speak of Earth Divers that brought our world out of the sand. But out of all of these creation stories, which one is the story that everyone remixed? In 1853, Hormuzd Rassam uncovered the Epic of Gilgamesh which dated back to as early as 1800 BCE. It speaks of a worldwide flood and is similar to the flood story we have in Genesis. However, upon further inspection there are varied differences. The Epic has been taken and translated from multiple tablets and each contain inconsistent narratives. Whereas with the Old Testament, while we have manuscripts that date all the way back to 1600 BCE, we have more consistent and reliable texts. We have, to date, over 12,000 manuscripts from the Old Testament compared to a handful of fragmented tablets for Gilgamesh.. One might think that our creation story has been derived from ancient Mesopotamian and Babylonian ...
https://papyrus.greenville.edu/2014/11/copy-paste/
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p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/A0A1J3IXG3
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Inspector Insight » mirror neuron
Over seven (and more) coming articles we will explore the basic plots outlined in Christopher Bookers classic book. The first of these is Overcoming the monster.. Dragons and ogres. Every culture has its stories of overcoming the monster, such as the English myth of George and the Dragon (perhaps the dragon is usually more fearsome than the one in the picture above). In The Seven Basic Plots, Christopher Booker discusses many examples of this plot including the original story of all which is the Epic of Gilgamesh. Overcoming the monster is the basic plot for Little Red Riding Hood, Hansel and Gretel, Jack and the Beanstalk and other childhood fairy tales, Greek legends such as many episodes from Homers poems and of course Perseus and Theseus, as well as Beowulf (based on an old English poem), Dracula and The War of the Worlds as well as the films High Noon, Jurassic Park, The Magnificent Seven and The Three Musketeers (to name a few). Read more ». ...
http://www.inspectorinsight.com/tag/mirror-neuron/
April 2008 - Page 2 of 3 - Gene Expression : Gene ExpressionApril 2008 - Page 2 of 3 - Gene Expression : Gene Expression
The reports about the widespread use of drugs, cognitive enhancers, among scientists is making the rounds. I tend to think that it might be a positive thing, even if there are side effects. The fact is that if you go into science youre looking at a life of relatively meager remuneration for the intellectual firepower you can bring to any question. Someone who has the abilities and skills to get a tenure track position could almost certainly have been able to make a go of it in a much higher paid profession, but they didnt. Why? Many reasons, from fame to doing what you love. The reality though is that most scientists dont really stand out, and unlike Gilgamesh no one will remember them in the future. I think that the culture of science does need a lot of warm bodies, so there is a positive spillover effect to someone spending their whole life in a scientific career, despite the fact that only a tiny minority of individuals will accrue to themselves the glory of immortality and acclaim.. Read ...
http://blogs.discovermagazine.com/gnxp/2008/04/page/2/
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http://everwayan.blogspot.com/2016/02/i-am-petty-god-at-moment.html
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Review of Biblical Literature
Description: Parts of well-known compositions such as Gilgamesh and Atrahasis, but some entirely new compositions: the Song of Bazi,hymn to Ningishzida, five love poems, and an extraordinary bilingual text in which an old scholar harangues his son.. Subjects: Ancient Near East, Mesopotamian Literature, Babylonian Literature, ...
https://www.bookreviews.org/bookdetail.asp?TitleId=7274
FOLLOWING THE FAINT FOOTSTEPS OF ANGELS Part 3 by Anna V. Palmer | Isle of Wight Spirit GuideFOLLOWING THE FAINT FOOTSTEPS OF ANGELS Part 3 by Anna V. Palmer | Isle of Wight Spirit Guide
FOLLOWING THE FAINT FOOTSTEPS OF ANGELS Part 3 IN THE EPIC OF GILGAMESH, written around 2,100 BC, we read of a sacred forest of Cedar trees where the gods dwelt and where their
https://isleofwight.thespiritguides.co.uk/Article_FOLLOWING_THE_FAINT_FOOTSTEPS_OF_ANGELS_Part_3_16437.aspx
rat HFE protein Summary Report | CureHunterrat HFE protein Summary Report | CureHunter
rat HFE protein: an MHC class I-like protein that must bind beta2-microglobulin for proper cell surface expression; GenBank AJ001517
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Animal Model Suggests Possible Cause for ADHD | www.bioquicknews.comAnimal Model Suggests Possible Cause for ADHD | www.bioquicknews.com
Using a mouse model they created, scientists at Rockefeller University and collaborating institutions have identified a gene (CK1 delta) that they believe merits investigation as a possible cause of attention-deficit/hyperactivity disorder (ADHD). Currently, the cause of ADHD is unknown, but there is increasing evidence that dopamine, a neurotransmitter involved in the brains reward-motivation system, is involved. Scientists have previously found that the levels of dopamine, and of the D2 receptor it binds to, are involved in the progression of ADHD, as are four connected regions in the frontal region of the brain, two of which are directly linked to reward and motivation. In their work, the scientists focused on an enzyme called casein kinase I (CK1), which is involved in regulating the dopamine signaling pathway. They created a line of mice genetically modified to overexpress a form of CK1 called CK1 delta, specifically in the forebrain of the mouse. Under normal conditions and in response to ...
http://www.bioquicknews.com/node/280
RCSB PDB - Protein Feature View - Casein kinase I isoform alpha - P67827 (KC1A BOVIN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://bioinformatics.sdsc.edu/pdb/protein/P35506
RCSB PDB - Protein Feature View - Casein kinase I isoform gamma-3 - Q9Y6M4 (KC1G3 HUMAN)RCSB PDB - Protein Feature View - Casein kinase I isoform gamma-3 - Q9Y6M4 (KC1G3 HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/protein/Q9Y6M4
Casein Kinase I Isoform Delta (Tau Protein Kinase CSNK1D or CKI Delta or CSNK1D or EC 2.7.11.1 or EC 2.7.11.26) - Pipeline...Casein Kinase I Isoform Delta (Tau Protein Kinase CSNK1D or CKI Delta or CSNK1D or EC 2.7.11.1 or EC 2.7.11.26) - Pipeline...
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https://www.marketresearch.com/Global-Markets-Direct-v3480/Casein-Kinase-Isoform-Delta-Tau-10293155/
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Ambling Along the Aqueduct: Annotated Book List #2
Cara needs to be something other than a weak female, so she can avenge her family. She takes on the fake magic that the old wives peddle, makes it real, and becomes a man, her slight body hung with slabs of muscle, massive thews and flesh-like living armour to wrap it all. . . Why cant she wish to become a woman warrior and kick ass that way? Because thats a different book. Because shes got to experience the weirdness of inhabiting a male body, thats the whole point. The Warrior Who Carried Life is fantasy Gilgamesh, a past distant beyond my imagining, (I cant get Gilgamesh to stick in my head, although Ive tried). Gruesome in the extreme, a pungent, meaty adventure that turns out to be a re-writing of Genesis, with Man as the serpent and Woman as the good guy. I think now as I thought then: a fine example of a story thats all about gender & not at all about politics.Give this guy a Tiptree!. ...
https://aqueductpress.blogspot.com/2007/11/annotated-book-list-2.html
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p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/A0A1S3FVH5
Casein Kinase | Cell Cycle|Stem Cells/Wnt| CSNpharmCasein Kinase | Cell Cycle|Stem Cells/Wnt| CSNpharm
Casein kinase (CK) are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription. The CK1 family of monomeric serine-threonine protein kinases is found in eukaryotic organisms from yeast to humans. Mammals have 7 family members: alpha, beta 1, gamma 1, gamma 2, gamma 3, delta, and epsilon. Casein kinase 1 epsilon has been suggested to play a role in phosphorylation of Disheveled in the Wnt signaling pathway.
https://www.csnpharm.com/casein-kinase.html
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How long would you like to live for? Is there a limit to how long we can live for? These are not questions you hear often, but do not be surprised if they are repeated more frequently in the future. The reason? Life extension. It is the concept of living well beyond the average lifespan. [1]. Humans are already living longer due to vaccines and improvements in sanitation. [2] The World Health Organization reported that the average life expectancy at birth increased from 48 years in 1955 to 65 years in 1995, and is projected to rise to 73 years by 2025. [3] As medical techniques continue to improve, we are more inclined than ever to pursue life extension. [1] Indeed, from the Epic of Gilgamesh to Chinas First Emperor, prolonging life has been an ever-present thought in society. [4, 5] Both individuals failed to escape death, but the idea of life extension ironically lives on. Even so, is it truly possible and what should upcoming doctors and scientists consider if they are to join the most ...
http://www.rationalargumentator.com/index/blog/tag/lifespan/
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Gilgamesh, Gods and Goddesses of Life and Death, Good Death, the, Gravestones and Other Markers, Greek Tragedy, Grief, Grief and Mourning in Cross-Cultural Perspective, Grief Counseling and Therapy, Heaven, Heavens Gate, etc…
http://www.deathreference.com/Ho-Ka/Hospice-Option.html
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Gilgamesh, Gods and Goddesses of Life and Death, Good Death, the, Gravestones and Other Markers, Greek Tragedy, Grief, Grief and Mourning in Cross-Cultural Perspective, Grief Counseling and Therapy, Heaven, Heavens Gate, etc…
http://www.deathreference.com/Ho-Ka/Immortality-Symbolic.html
History Of Dreaming | dreamhawk.comHistory Of Dreaming | dreamhawk.com
Based on the beliefs of early cultures such as the Australian Aborigines and the Kalahari Bushmen, we can be certain dreams were an important part of the life of early human beings. The earliest know record of dreams is recorded in the epic poem Gilgamesh, which is 4000 years old. The text includes an account of a series of dreams.. From the earliest ages in mankinds shrouded history, dreams have been a source of wonder and speculation, inspiration and fear. This chapter deals with some of the explanations men have given for why and how one dreams. It must be understood, however, that these various accounts are put here, not because they are necessarily correct accounts of dreaming, but simply to give a background of information on the dream.. The most ancient peoples, whether separated by seas, geographical barriers, or culture, usually had in common an enormous respect for dreams. Many early societies had a very dualistic philosophy regarding life. That is, they believed that their life was ...
https://dreamhawk.com/dream-encyclopedia/history-of-dreaming/
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Gil, depicted as surprised as you are that he finally got his own thread Who is Gil? The average Gil, diagramed Prince Gilgamesh, usually known simply...
https://smashboards.com/threads/tower-of-druagas-gil-zaps-to-smash.515054/
Casein Kinase II (CK2) | NEBCasein Kinase II (CK2) | NEB
Casein Kinase II (CKII) is a constitutively active serine/threonine protein kinase and the general recognition motif for phsophorylation is SXXE/D.
https://www.neb.com/products/p6010-casein-kinase-ii-ck2
CSNK1A1 (CK1 α 1) Recombinant Human ProteinCSNK1A1 (CK1 α 1) Recombinant Human Protein
CNSK1A1 (CK1 alpha 1) is a member of the casein kinase I (CKI) gene family, which encodes serinethreonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric, ranging from 25 to 55 kD, and are found in the nuclei, cytoplasm, and membrane fractions of eukaryotic ce
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The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer developmentThe role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development
The members of the casein kinase 1 (CK1) family are highly conserved and are expressed in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, cir …
https://pubmed.ncbi.nlm.nih.gov/16186692/?dopt=Abstract
CK2 alpha | casein kinase 2 subunit alphaCK2 alpha | casein kinase 2 subunit alpha
anti-CK2alpha | casein kinase 2 subunit alpha antibodies, UniProt: Q08467, Q08466, O64817, O64816, At5g67380, At3g50000, At2g23080, At2g23070, anti-CKA, CKA, CK2 alpha, AS16 3212
http://www.agrisera.com/en/artiklar/plantalgal-cell-biology/photosynthesis-/kinases/ck2-alpha-casein-kinase-2-subunit-alpha.html
CK2 beta | casein kinase 2 subunit betaCK2 beta | casein kinase 2 subunit beta
anti-CK2beta | casein kinase 2 subunit beta antibodies, UniProt: P40228, P40229, O81275, O80507, At5g47080, At4g17640, At3g60250, At2g44680, anti-CKB, CKB, CK2 beta, AS16 3213
http://www.agrisera.com/en/artiklar/plantalgal-cell-biology/photosynthesis-/kinases/ck2-beta-casein-kinase-2-subunit-beta.html
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Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, Demaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. A structural basis for substrate specificities of protein ser/thr kinases-primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, Cdk5 and ERK1. Mol Cell Biol 1996;16:6486-93 ...
http://tsailaboratory.mit.edu/publications/
CK1 substrate, 1 mg (HQ)CK1 substrate, 1 mg (HQ)
The synthetic peptide RRKDLHDDEEDEAMSITA can be used as a substrate for casein kinase 1 (CK1) in in vitro kinase assays. It is phosphorylated by CK1 with a Km of 172 �M
https://www.proteinkinase.biz/peptide-substrates/215-ck1-substrate-1-mg-hq.html
PATCH] Implement D3DXMatrixTransformation with a testPATCH] Implement D3DXMatrixTransformation with a test
dlls/d3dx8/d3dx8.spec , 2 +- dlls/d3dx8/math.c , 80 ++++++++++++++++++++++++++++++++++++++++++++= +++ dlls/d3dx8/tests/math.c , 16 ++++++++- include/d3dx8math.h , 1 + 4 files changed, 96 insertions(+), 3 deletions(-) diff --git a/dlls/d3dx8/d3dx8.spec b/dlls/d3dx8/d3dx8.spec index 52fa008..28b772e 100644 --- a/dlls/d3dx8/d3dx8.spec +++ b/dlls/d3dx8/d3dx8.spec @@ -33,7 +33,7 @@ @ stdcall D3DXMatrixRotationAxis(ptr ptr long) @ stdcall D3DXMatrixRotationQuaternion(ptr ptr) @ stdcall D3DXMatrixRotationYawPitchRoll(ptr long long long) [email protected] stub D3DXMatrixTransformation [email protected] stdcall D3DXMatrixTransformation(ptr ptr ptr ptr ptr ptr ptr) @ stdcall D3DXMatrixAffineTransformation(ptr long ptr ptr ptr) @ stdcall D3DXMatrixLookAtRH(ptr ptr ptr ptr) @ stdcall D3DXMatrixLookAtLH(ptr ptr ptr ptr) diff --git a/dlls/d3dx8/math.c b/dlls/d3dx8/math.c index 9f7522e..04072bf 100644 --- a/dlls/d3dx8/math.c +++ b/dlls/d3dx8/math.c @@ -480,6 +480,86 @@ D3DXMATRIX* WINAPI D3DXMatrixShadow(D3DXMATRIX *pout, C= ONST ...
https://www.winehq.org/pipermail/wine-patches/2007-November/047098.html
Description: Víc než jen moudrý klaun /
KOPTA, Václav: Víc než jen moudrý klaun. [Rozmlouval] Tomáš Šťástka. Mladá fronta Dnes. Roč. 32, 2021, č. 75, 30. 3., s. 15 ...
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Casein Kinase Protein | CK2 | CSNK1 | CSNK2 | ProSpecCasein Kinase Protein | CK2 | CSNK1 | CSNK2 | ProSpec
ProSpecs Casein Kinases include: Casein Kinase 2 alpha Human Recombinant, Casein Kinase 2 alpha Human Recombinant His, Casein Kinase 2 beta Human Recombinant Active, Casein Kinase 2 Beta Human Recombinant, Casein Kinase 2 alpha Zea Mays Recombinant, Casein Kinase 2 Holoenzyme Human Recombinant
https://www.prospecbio.com/casein_kinase-2
Casein kinase 2 and protein substrates are released from rat liver cells nuclei by DNase or RNase digestion<...Casein kinase 2 and protein substrates are released from rat liver cells nuclei by DNase or RNase digestion<...
TY - JOUR. T1 - Casein kinase 2 and protein substrates are released from rat liver cells nuclei by DNase or RNase digestion. AU - Bosser, Ramon. AU - Roig, Joan. AU - Itarte, Emilio. AU - Bachs, Oriol. PY - 1994/7/29. Y1 - 1994/7/29. N2 - Casein kinase 2 was released from rat liver cells nuclei by digestion with DNase 1 plus RNase A. This treatment also released three major substrates of 50, 40-42, and 37 kDa. Casein kinase 2 and substrates were also extracted by DNase or RNase separately. However, in DNase extracts only the 37 kDa protein was phosphorylated by casein kinase 2, whereas in RNase extracts all three substrates were phosphorylated. When the DNase extracts were subsequently treated with RNase the 40-42 substrates were then phosphorylated, indicating that their interaction with RNA prevents their phosphorylation by casein kinase 2. The ratio of β:α subunits of casein kinase 2 present in the nuclease extracts was higher than that of the purified enzyme, which is assumed to be 1:1. A ...
https://portalrecerca.uab.cat/en/publications/casein-kinase-2-and-protein-substrates-are-released-from-rat-live-2
Monopolar attachment of sister kinetochores at meiosis 1 requires casein kinase 1. Kinetochore orientation in mitosis and...Monopolar attachment of sister kinetochores at meiosis 1 requires casein kinase 1. Kinetochore orientation in mitosis and...
Monopolar attachment of sister kinetochores at meiosis 1 requires casein kinase 1. Kinetochore orientation in mitosis and meiosis
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Casein kinaseCasein kinase
... , a type of kinase enzyme, may refer to: Casein kinase 1, serine/threonine-selective protein kinase family Casein ... kinase 2, a serine/threonine-selective protein kinase This article includes a list of related items that share the same name ( ... Protein kinases, All stub articles, Enzyme stubs). ...
https://en.wikipedia.org/wiki/Casein_kinase
Casein kinase 1Casein kinase 1
... "casein kinase 1 alpha" and "casein kinase 1 epsilon". Casein kinase 1 epsilon has been suggested to play a role in ... Casein kinase 2 - a distinct protein kinase family Eide EJ, Virshup DM (May 2001). "Casein kinase I: another cog in the ... In humans there are three casein kinase 1 gamma enzymes. Xenopus casein kinase 1 gamma (CK1gamma) is associated with the cell ... "A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of ...
https://en.wikipedia.org/wiki/Casein_kinase_1
Casein kinase 2Casein kinase 2
... (EC 2.7.11.1)(CK2/CSNK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle ... CSNK2A1 CSNK2A2 Casein kinase 1 - a distinct protein kinase family Ahmad KA, Wang G, Unger G, Slaton J, Ahmed K (2008). " ... Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin- ... Gao Y, Wang HY (2006). "Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling". The Journal of Biological ...
https://en.wikipedia.org/wiki/Casein_kinase_2
Casein kinase 1, alpha 1Casein kinase 1, alpha 1
Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. Casein kinase 1, alpha 1 has been ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024576 ... Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ...
https://en.wikipedia.org/wiki/Casein_kinase_1,_alpha_1
Casein kinase 2, alpha 1Casein kinase 2, alpha 1
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as ... Casein kinase 2, alpha 1 has been shown to interact with: APC, ATF1, ATF2, C-Fos, C-jun, CDC25B, CHEK1, CREBBP, CSNK2B, DDIT3, ... "Entrez Gene: CSNK2A1 casein kinase 2, alpha 1 polypeptide". Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y (April 2002). " ... Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. ...
https://en.wikipedia.org/wiki/Casein_kinase_2,_alpha_1
Casein kinase 1 isoform epsilonCasein kinase 1 isoform epsilon
The protein encoded by the casein kinase 1 epsilon gene is a serine/threonine protein kinase and a member of the casein kinase ... Casein kinase 1 epsilon, and related casein kinase 1 delta, is dephosphorylated in this pathway. Dephosphorylation of casein ... The current theory for how casein kinase 1 epsilon and/or casein kinase 1 delta function in this pathway is that both casein ... After priming through phosphorylation by the serine/threonine kinase LATS, both casein kinase 1 epsilon and casein kinase 1 ...
https://en.wikipedia.org/wiki/Casein_kinase_1_isoform_epsilon
EEF1B2EEF1B2
Phosphorylation by casein kinase II". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1264 (3): 303-11. ... Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". ... Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry. ...
https://en.wikipedia.org/wiki/EEF1B2
Centaurin, alpha 1Centaurin, alpha 1
Casein kinase 1, alpha 1 Nucleolin, P110α, PRKCI, Protein kinase D1, and Protein kinase Mζ. Model organisms have been used in ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1-3): 167-71. doi:10.1016/s0014-5793( ...
https://en.wikipedia.org/wiki/Centaurin,_alpha_1
ERF (gene)ERF (gene)
Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners ... "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation". ...
https://en.wikipedia.org/wiki/ERF_(gene)
PPP1R14APPP1R14A
Zemlickova E, Johannes FJ, Aitken A, Dubois T (March 2004). "Association of CPI-17 with protein kinase C and casein kinase I". ... Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners ... Multiple kinases are identified to phosphorylate CPI-17, such as PKC, ROCK, PKN, ZIPK, ILK, and PAK. Agonist stimulation of ... Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 ...
https://en.wikipedia.org/wiki/PPP1R14A
SYT9SYT9
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological ... "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological ...
https://en.wikipedia.org/wiki/SYT9
AP3B1AP3B1
Kim YM, Barak LS, Caron MG, Benovic JL (May 2002). "Regulation of arrestin-3 phosphorylation by casein kinase II". The Journal ... Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ...
https://en.wikipedia.org/wiki/AP3B1
MycMyc
Lüscher B, Kuenzel EA, Krebs EG, Eisenman RN (April 1989). "Myc oncoproteins are phosphorylated by casein kinase II". The EMBO ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ... Gupta S, Davis RJ (October 1994). "MAP kinase binds to the NH2-terminal activation domain of c-Myc". FEBS Letters. 353 (3): 281 ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ...
https://en.wikipedia.org/wiki/Myc
HMGB2HMGB2
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". ... "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in ...
https://en.wikipedia.org/wiki/HMGB2
SMIM19SMIM19
... down-regulation of Casein kinase 2 can promote tumorigenesis. Protein kinase C is a protein-regulator and is highly involved in ... Casein kinase 2 can play a role in cell cycle regulation, DNA repair, and necessary for cell survival; ...
https://en.wikipedia.org/wiki/SMIM19
Thymosin α1Thymosin α1
1992). "Prothymosin alpha is phosphorylated by casein kinase-2". FEBS Lett. 312 (2-3): 152-6. doi:10.1016/0014-5793(92)80924-6 ...
https://en.wikipedia.org/wiki/Thymosin_α1
Doubletime (gene)Doubletime (gene)
The casein kinase 1 (CKI) family of kinases is a highly conserved group of proteins that are found in organisms from ... Sekine T, Yamaguchi T, Hamano K, Young MW, Shimoda M, Saez L (February 2008). "Casein kinase I epsilon does not rescue double- ... The mammalian homolog of doubletime is casein kinase I epsilon. Different mutations in the dbt gene have been shown to cause ... Fan JY, Preuss F, Muskus MJ, Bjes ES, Price JL (January 2009). "Drosophila and vertebrate casein kinase Idelta exhibits ...
https://en.wikipedia.org/wiki/Doubletime_(gene)
NucleolinNucleolin
Li D, Dobrowolska G, Krebs EG (Jun 1996). "The physical association of casein kinase 2 with nucleolin". The Journal of ... Li D, Dobrowolska G, Krebs EG (Jun 1996). "The physical association of casein kinase 2 with nucleolin". The Journal of ... Jordan P, Heid H, Kinzel V, Kübler D (Dec 1994). "Major cell surface-located protein substrates of an ecto-protein kinase are ... Zhou G, Seibenhener ML, Wooten MW (Dec 1997). "Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface ...
https://en.wikipedia.org/wiki/Nucleolin
Gap-43 proteinGap-43 protein
Apel ED, Litchfield DW, Clark RH, Krebs EG, Storm DR (Jun 1991). "Phosphorylation of neuromodulin (GAP-43) by casein kinase II ... It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and ... However, F1 was not cAMP kinase dependent. B-50 was regulated by the pituitary peptide ACTH and was associated with grooming ... GAP-43 is also a protein kinase C (PKC) substrate. Phosphorylation of serine-41 on GAP-43 by PKC regulates neurite formation, ...
https://en.wikipedia.org/wiki/Gap-43_protein
ARR3ARR3
Kim YM, Barak LS, Caron MG, Benovic JL (2002). "Regulation of arrestin-3 phosphorylation by casein kinase II". J. Biol. Chem. ...
https://en.wikipedia.org/wiki/ARR3
GJA1GJA1
Cooper CD, Lampe PD (Nov 2002). "Casein kinase 1 regulates connexin-43 gap junction assembly". The Journal of Biological ... factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase ...
https://en.wikipedia.org/wiki/GJA1
WNT3AWNT3A
Hino S, Michiue T, Asashima M, Kikuchi A (April 2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is ... Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM (March 2004). "Regulation of casein kinase I epsilon ...
https://en.wikipedia.org/wiki/WNT3A
NCK1NCK1
Lussier G, Larose L (1997). "A casein kinase I activity is constitutively associated with Nck". J. Biol. Chem. 272 (5): 2688-94 ... "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta". J ... Su YC, Han J, Xu S, Cobb M, Skolnik EY (March 1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates ... Su YC, Han J, Xu S, Cobb M, Skolnik EY (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the ...
https://en.wikipedia.org/wiki/NCK1
TEDDM1TEDDM1
... a casein kinase II phosphorylation site, a Leucine zipper pattern, two N-myristylation sites, and three protein kinase C ... Casein kinase II is involved with protein stability and cell signaling response. Leucine zippers are sequence motifs that ... Litchfield DW, Lüscher B (November 1993). Khandelwal RL, Wang JH (eds.). "Casein kinase II in signal transduction and cell ... Protein kinase C phosphorylation has to do with regulation of cell proliferation and gene expression. The secondary structure ...
https://en.wikipedia.org/wiki/TEDDM1
ISLRISLR
Phosphatidylinositol 3-kinase related kinase (PIKK) phosphorylation site at position 238-244 aa. Casein kinase (CK1) ... Polo-like kinase phosphosites 1 (Plk1) at positions 336-342 aa and 351-357 aa. Ser/Thr residues are phosphorylated by the ... Ser/Thr residues are phosphorylated by the kinase. Two NEK2 phosphorylation sites at positions 415-420 bp and 423-428 aa. Table ... Glycogen synthase kinase-3 (GSK3) phosphorylation site at position 234-241 aa. ...
https://en.wikipedia.org/wiki/ISLR
CCDC113CCDC113
CSNK2A2 the casein kinase 2, alpha prime polypeptide contains a protein kinase domain and a catalytic domain. GINS3 is ... "CSNK2A2 casein kinase 2, alpha prime polypeptide [ Homo sapiens (human) ]". NCBI. Retrieved May 8, 2013. "GINS3 GINS complex ... Interacting proteins found using two-hybrid screening techniques include GIT1; a G protein-coupled receptor kinase interacting ...
https://en.wikipedia.org/wiki/CCDC113
DNA damage-inducible transcript 3DNA damage-inducible transcript 3
Ubeda M, Habener JF (October 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional ... which then activates the downstream kinases, Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK), ... Those processes are mainly regulated by three factors: protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating ... double-stranded RNA-activated protein kinase (PKR) iron deficiency through heme-regulated inhibitor kinase (HRI) stress from ...
https://en.wikipedia.org/wiki/DNA_damage-inducible_transcript_3
DVL1DVL1
Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM (2002). "Casein kinase I phosphorylates and destabilizes the beta-catenin ... "Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon". J. Biol. Chem. ... Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells ...
https://en.wikipedia.org/wiki/DVL1
GlobozoospermiaGlobozoospermia
Xu, X.; Toselli, P. A.; Russell, L. D.; Seldin, D. C. (1999-09-01). "Globozoospermia in mice lacking the casein kinase II alpha ...
https://en.wikipedia.org/wiki/Globozoospermia
Nucleolar phosphoprotein p130Nucleolar phosphoprotein p130
Li D, Meier UT, Dobrowolska G, Krebs EG (1997). "Specific interaction between casein kinase 2 and the nucleolar protein Nopp140 ... Chiu CM, Tsay YG, Chang CJ, Lee SC (2002). "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the ...
https://en.wikipedia.org/wiki/Nucleolar_phosphoprotein_p130
Herpes simplex virus protein vmw65Herpes simplex virus protein vmw65
... at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase ...
https://en.wikipedia.org/wiki/Herpes_simplex_virus_protein_vmw65
Index of biochemistry articlesIndex of biochemistry articles
... ribosomal protein S6 kinase - ribosome - RNA - RNA virus - RNA-binding protein - RNA-directed DNA polymerase - rod outer ... casein - catabolism - catalyst - catalytic domain - CCR5 receptor - CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein ... kinase - kinesin - kinetic energy - kinetic exclusion assay - kinetics - knock-out mouse - Krebs cycle lactalbumin - lactic ... src-family kinase - SSRI - starch - stem cell - stereochemistry - steroid 17alpha-monooxygenase - steroid 21-monooxygenase - ...
https://en.wikipedia.org/wiki/Index_of_biochemistry_articles
Anticancer geneAnticancer gene
NS1 specifically targets and degrades the microfilament tropomyosin using casein kinase II, actin filaments through activation ... interacts with kinases including serine/threonine protein kinase (PKR). Further studies will need to be performed to better ... E4orf4 partners mainly with protein phosphatase 2A (PP2A) and Src kinases to induce cell death. Modeling of this protein ... as well as a place for Src kinases to bind. E4orf4 is an important regulator of adenoviruses. Additionally, outside of the ...
https://en.wikipedia.org/wiki/Anticancer_gene
Cyclin-dependent kinase 1Cyclin-dependent kinase 1
Russo GL, Vandenberg MT, Yu IJ, Bae YS, Franza BR, Marshak DR (1992). "Casein kinase II phosphorylates p34cdc2 kinase in G1 ... Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, ... Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ... In addition to this catalytic core, Cdk1, like other cyclin-dependent kinases, contains a T-loop, which, in the absence of an ...
https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_1
SCF complexSCF complex
"Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF ( ... βTRCP recognizes these substrates after they are phosphorylated by Polo-like kinase 1 or Cyclin B-CDK1. Fbw7, which is the ... Schwob, E (1994-10-21). "The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae". Cell. 79 ... p130 cyclin-dependent kinase inhibitors (CKIs): p27Kip1, p21, Wee1 centriole proteins: Cep250, Ninein There are approximately ...
https://en.wikipedia.org/wiki/SCF_complex
Period (gene)Period (gene)
This PER/CRY complex moves into the nucleus upon phosphorylation by CK1-epsilon (casein kinase 1 epsilon) and inhibits the CLK/ ... "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular Cell Biology. 20 ...
https://en.wikipedia.org/wiki/Period_(gene)
Shellfish allergyShellfish allergy
In addition to tropomyosin, arginine kinase and hemocyanin seem to have a role in cross-reactivity to dust mites. Exercise can ... "Casein (milk)," or as an alternative, there must be a statement separate but adjacent to the ingredients list: "Contains milk ... Tropomyosin, arginine kinase, myosin light chain and sarcoplasmic calcium-binding protein are widely present across shellfish ... As of a 2016 review, only three (tropomyosin, arginine kinase and sarcoplasmic calcium-binding protein) were available for ...
https://en.wikipedia.org/wiki/Shellfish_allergy
CHKACHKA
Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ... Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat ... Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. The major pathway for the biosynthesis of ... 1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4 ...
https://en.wikipedia.org/wiki/CHKA
FER (gene)FER (gene)
Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase". FEBS Lett. 215 (2): ... Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of ... 2000). "FER kinase activation of Stat3 is determined by the N-terminal sequence". J. Biol. Chem. 275 (37): 28902-10. doi: ... "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)". Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U ...
https://en.wikipedia.org/wiki/FER_(gene)
Jay DunlapJay Dunlap
He and his colleagues genetically increased the Casein Kinase 1 levels and found that the period was restored when Casein ... They concluded that the circadian period is dependent on Casein Kinase 1 levels. During Dunlap's time at Santa Cruz, one of the ... In his most recent work, Dunlap's lab examined regulators of the mRNAs encoding the Casein Kinase 1 protein; one such regulator ... namely Casein Kinase 2) on the temperature compensation mechanism. In 2009, Dunlap and colleagues showed that the FRQ protein ...
https://en.wikipedia.org/wiki/Jay_Dunlap
Collagen, type XVII, alpha 1Collagen, type XVII, alpha 1
Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain, phosphorylation negatively ... "Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding". J Biol Chem. 282 (31): ...
https://en.wikipedia.org/wiki/Collagen,_type_XVII,_alpha_1
LOC100287387LOC100287387
... casein kinase 2 (CK2), and protein kinase C (PKC) phosphorylation sites, O-linked beta-N-acetylglucosamine sites, and a ... a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy". Molecular & Cellular Proteomics. 7 (9): 1598-1608. doi: ...
https://en.wikipedia.org/wiki/LOC100287387
Forkhead box protein O1Forkhead box protein O1
Casein kinase 1, a growth factor-activated protein kinase, also phosphorylates and potentiates FOXO1 and translocates FOXO1 to ... Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T (June 1999). "Phosphorylation of serine 256 by protein kinase B disrupts ... The transcription and half- life of cyclin-dependent kinase inhibitor p27KIP1 rises when FOXO1 is active. A study detects that ... AKT, which is referred to as protein kinase B, phosphorylates FOXO1 and accumulates in the cytosol. ...
https://en.wikipedia.org/wiki/Forkhead_box_protein_O1
CDC25BCDC25B
... has been shown to interact with MAPK14, Casein kinase 2, alpha 1, CHEK1, MELK, Estrogen receptor alpha, YWHAB, YWHAZ, ... Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity ... CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. ... 1993). "Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase". FEBS Lett. 318 (3): ...
https://en.wikipedia.org/wiki/CDC25B
Phenolic content in winePhenolic content in wine
If there is an excess in the amount of tannins in the wine, winemakers can use various fining agents like albumin, casein and ... induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway ...
https://en.wikipedia.org/wiki/Phenolic_content_in_wine
PIN1PIN1
Casein kinase 2, alpha 1, DAB2, eNOS, FOXO4, MPHOSPH1, MYT1, Mothers against decapentaplegic homolog 2, Mothers against ... Pin1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates ... "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M ... "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M ...
https://en.wikipedia.org/wiki/PIN1
Homeobox protein Nkx-2.5Homeobox protein Nkx-2.5
Kasahara H, Izumo S (January 1999). "Identification of the in vivo casein kinase II phosphorylation site within the homeodomain ... Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (October 1998). "Homeodomain-interacting protein kinases, a novel family of co- ...
https://en.wikipedia.org/wiki/Homeobox_protein_Nkx-2.5
PAK1PAK1
STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl transferase V, B-Raf proto-oncogene, casein kinase 2 ... Shin YJ, Kim YB, Kim JH (September 2013). "Protein kinase CK2 phosphorylates and activates p21-activated kinase 1". Molecular ... casein kinase II, Rac3, chemokine (C-X-C motif) ligand 1, breast cancer anti-estrogen resistance 3, Kaposi's sarcoma-associated ... "The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1". The Journal of Biological ...
https://en.wikipedia.org/wiki/PAK1
CSN1S1CSN1S1
Alpha-S1-casein is a protein that in humans is encoded by the CSN1S1 gene. CSN1S1 has been shown to interact with SAP130. ... Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. ... "Entrez Gene: CSN1S1 casein alpha s1". Menon, Suchithra; Tsuge Tomohiko; Dohmae Naoshi; Takio Koji; Wei Ning (2008). " ... Xu K, Ling MT, Wang X, Wong YC (2007). "Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate ...
https://en.wikipedia.org/wiki/CSN1S1
IWS1IWS1
... and is phosphorylated at casein kinase II (CKII) sites. The human homolog, which physically interacts with protein arginine ...
https://en.wikipedia.org/wiki/IWS1
AP3B2AP3B2
"The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform". ...
https://en.wikipedia.org/wiki/AP3B2
CTP synthetaseCTP synthetase
Additionally, Ser568 has been seen to be phosphorylated by casein kinase 1, inhibiting CTP synthase activity. CTP is also ... One major example of this is phosphorylation of the Ser-571 residue by glycogen synthase kinase 3 (GSK3) in response to low ... "Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3". The Journal of Biological Chemistry. 282 ...
https://en.wikipedia.org/wiki/CTP_synthetase
Catenin beta-1Catenin beta-1
In the case of beta-catenin, the most important priming kinase is Casein Kinase I (CKI). Once a serin-threonine rich substrate ... Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y (April 2002). "Association and regulation of casein kinase 2 activity by adenomatous ... Li Y, Kuwahara H, Ren J, Wen G, Kufe D (March 2001). "The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 ... Ren J, Li Y, Kufe D (May 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin ...
https://en.wikipedia.org/wiki/Catenin_beta-1
Chromosome 22Chromosome 22
... encoding enzyme Casein kinase I isoform epsilon or CK1ε, DGCR5: encoding a long non-coding RNA DGCR6: DiGeorge Syndrome ... encoding enzyme Phosphatidylinositol 4-kinase alpha PI4KAP2: pseudogene phosphatidylinositol 4-kinase alpha pseudogene 2 PISD: ...
https://en.wikipedia.org/wiki/Chromosome_22
Casein Kinase Iepsilon | Profiles RNS
"Casein Kinase Iepsilon" by people in this website by year, and whether "Casein Kinase Iepsilon" was a major or minor topic of ... "Casein Kinase Iepsilon" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM. ... Below are the most recent publications written about "Casein Kinase Iepsilon" by people in Profiles. ...
https://profiles.umassmed.edu/display/114467
Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε<...
Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε. In: Molecular and cellular biology ... Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε. Molecular and cellular biology. ... The Drosophila double-time gene product, a casein kinase I ε (CKIε) homolog, has been reported to interact with dPER and ... The Drosophila double-time gene product, a casein kinase I ε (CKIε) homolog, has been reported to interact with dPER and ...
https://pennstate.pure.elsevier.com/en/publications/nuclear-entry-of-the-circadian-regulator-mper1-is-controlled-by-m
casein kinase 2, alpha 1 polypeptide subunit | Casein kinase 2 (CK2) family | IUPHAR/BPS Guide to PHARMACOLOGYcasein kinase 2, alpha 1 polypeptide subunit | Casein kinase 2 (CK2) family | IUPHAR/BPS Guide to PHARMACOLOGY
Casein kinase 2 (CK2) family. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance ... Casein kinase 2 (CK2) family: casein kinase 2, alpha 1 polypeptide subunit. Last modified on 23/08/2017. Accessed on 02/12/2022 ... CSNK2A1 is included in Guide to IMMUNOPHARMACOLOGY as it is a subunit of the casein kinase 2 complex.. ... EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen A screen profiling 158 kinase inhibitors ( ...
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1549
Casein Kinase I Gamma 3 CSNK1G3 AntibodyCasein Kinase I Gamma 3 CSNK1G3 Antibody
Boster Bio Anti-Casein Kinase I Gamma 3 CSNK1G3 Antibody catalog # A12301. Tested in WB applications. This antibody reacts with ... CSNK1G3 casein kinase 1 gamma 3 casein kinase I isoform gamma-3,casein kinase I ... Anti-Casein Kinase I Gamma 3 CSNK1G3 Antibody. CKI gamma 3 antibody. Boster Bio Anti-Casein Kinase I Gamma 3 CSNK1G3 Antibody ... casein kinase 1, gamma 3; casein kinase I isoform gamma-3; CKI-gamma 3; EC 2.7.11; EC 2.7.11.1 CSNK1G3 CKI-gamma 3L, ...
https://www.bosterbio.com/anti-casein-kinase-i-gamma-3-csnk1g3-antibody-a12301-boster.html
Casein Kinase II | Profiles RNS
A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase ... "Casein Kinase II" by people in this website by year, and whether "Casein Kinase II" was a major or minor topic of these ... "Casein Kinase II" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Regulation of arrestin-3 phosphorylation by casein kinase II. J Biol Chem. 2002 May 10; 277(19):16837-46. ...
https://profiles.jefferson.edu/display/28273
ProViz - Casein kinase I isoform epsilon - CSNK1E - P49674ProViz - Casein kinase I isoform epsilon - CSNK1E - P49674
ProViz is an interactive protein exploration tool, which searches several databases for information about a given query protein. Data relevant to the protein like an alignment of homologues, linear motifs, post translational modifications, domains, secondary structure, sequence variations and others are graphically represented relative to their position in the protein.
http://slim.icr.ac.uk/proviz/proviz.php?uniprot_acc=P49674&alignment=QFO&ali_start=379&ali_end=399
Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells<...Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells<...
Ko, H., Kim, S., Jin, C. H., Lee, E., Ham, S., Yook, J. I., & Kim, K. (2012). Protein kinase casein kinase 2-mediated ... Ko, H, Kim, S, Jin, CH, Lee, E, Ham, S, Yook, JI & Kim, K 2012, Protein kinase casein kinase 2-mediated upregulation of N- ... Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells. ... Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells. In ...
https://yonsei.pure.elsevier.com/en/publications/protein-kinase-casein-kinase-2-mediated-upregulation-of-n-cadheri
Anti Casein Kinase 1 Epsilon Antibody, clone OTI5C9 (PrecisionAb Monoclonal Antibody) | Bio-RadAnti Casein Kinase 1 Epsilon Antibody, clone OTI5C9 (PrecisionAb Monoclonal Antibody) | Bio-Rad
Casein kinase 1 epsilon antibody for detecting human casein kinase 1 isoform epsilon. Validated on up to 12 cell lysates for ... Encoded by the CSNK1E gene, casein kinase 1 epsilon is a serine/threonine protein kinase and a member of the casein kinase I ... Mouse anti Human casein kinase 1 epsilon antibody recognizes the casein kinase I isoform epsilon, also known as CKI-epsilon, ... Mouse anti Casein Kinase 1 Epsilon. Product Type. PrecisionAb Monoclonal. Clone. OTI5C9. Isotype. IgG2a. Format. Purified. ...
https://www.bio-rad-antibodies.com/monoclonal/human-casein-kinase-1-epsilon-antibody-oti5c9-vma00258.html
Rabbit polyclonal to GST - Protein kinase A and casein kinases mediate sequential phosphorylation events
by caseinkinase 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) which may be detected in processed meats and red meats ...
http://www.casein-kinase.info/tag/rabbit-polyclonal-to-gst/
IMSEAR at SEARO: Phosphorylation of casein, fibrinogen and calmodulin by a glycoprotein protein kinase from monkey cerebellum:...
Phosphorylation of casein, fibrinogen and calmodulin by a glycoprotein protein kinase from monkey cerebellum: a casein kinase ... Phosphorylation of casein, fibrinogen and calmodulin by a glycoprotein protein kinase from monkey cerebellum: a casein kinase ... The collective results suggested that the enzyme from monkey cerebellum was a casein kinase II-like protein kinase and that ... These characteristics were typical of casein kinase II. The protein kinase also phosphorylated fibrinogen and calmodulin and ...
https://imsear.searo.who.int/handle/123456789/28905
Activation of casein kinase II in response to insulin and to epidermal growth factor - WikidataActivation of casein kinase II in response to insulin and to epidermal growth factor - Wikidata
Phosphorylation of site 5 by glycogen synthase kinase-5 (casein kinase-II) is a prerequisite for phosphorylation of sites 3 by ... Activation of casein kinase II in response to insulin and to epidermal growth factor (English) ... Activation of casein kinase II in response to insulin and to epidermal growth factor. scientific article ... Synergistic phosphorylation and activation of ATP-Mg-dependent phosphoprotein phosphatase by F A/GSK-3 and casein kinase II ( ...
https://m.wikidata.org/wiki/Q34376018
'Genuine' Casein Kinase (Fam20C): The Mother of the Phosphosecretome - Fingerprint - University of Texas Southwestern...
"Genuine" Casein Kinase (Fam20C): The Mother of the Phosphosecretome. Giorgio Cozza, Vincent S. Tagliabracci, Jack E. Dixon, ... Dive into the research topics of "Genuine" Casein Kinase (Fam20C): The Mother of the Phosphosecretome. Together they form a ...
https://utsouthwestern.pure.elsevier.com/en/publications/genuine-casein-kinase-fam20c-the-mother-of-the-phosphosecretome/fingerprints/
3wik.1 | SWISS-MODEL Template Library
Casein kinase II subunit alpha: A. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ... Nakanishi, I. et al., Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening. To be ...
https://swissmodel.expasy.org/templates/3wik.1
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling - SFB1324RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling - SFB1324
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling. ...
https://sfb1324.de/publication/rna-helicase-ddx3-is-a-regulatory-subunit-of-casein-kinase-1-in-wnt-beta-catenin-signaling/
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular LymphomaB-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma
Umbralisib- Dual inhibitor of PI3K and casein kinase epsilon Options for second-line consolidation or extended dosing (optional ... Targeting Bruton tyrosine kinase with ibrutinib in relapsed/refractory marginal zone lymphoma. Blood. 2017 Apr 20. 129 (16): ...
https://www.medscape.com/answers/202677-89827/what-are-the-flipi2-risk-stratification-factors-for-nhlb-cell-follicular-lymphoma
The down-regulation of casein kinase 1 alpha as a host defense response against infectious bursal disease virus infection. -...
Casein Kinase I Cell Line Chick Embryo Down-Regulation Fibroblasts Gene Expression Regulation, Enzymologic Infectious bursal ... The down-regulation of casein kinase 1 alpha as a host defense response against infectious bursal disease virus infection. ... In the present study, casein kinase 1 alpha (CK1α), a novel VP2-associated protein, was down-regulated during IBDV replication ... The down-regulation of casein kinase 1 alpha as a host defense response against infectious bursal disease virus infection. ...
https://accounts.public.ce.basespace.illumina.com/b/search/article.nb?id=28988058
RAPID STIMULATION OF SER THR PROTEIN-KINASES FOLLOWING TREATMENT OF SWISS 3T3 CELLS WITH BOMBESIN - INVOLVEMENT OF CASEIN...RAPID STIMULATION OF SER THR PROTEIN-KINASES FOLLOWING TREATMENT OF SWISS 3T3 CELLS WITH BOMBESIN - INVOLVEMENT OF CASEIN...
... and G peptide kinase activities and two MBP kinase peaks. Both MBP- and several S6 peptide kinase peaks could be inactivated by ... and G peptide kinase activities and two MBP kinase peaks. Both MBP- and several S6 peptide kinase peaks could be inactivated by ... The S6 peptide kinases as well as the two MBP kinases stimulated in response to bombesin are similar to those activated by ... The S6 peptide kinases as well as the two MBP kinases stimulated in response to bombesin are similar to those activated by ...
https://www.research.unipd.it/handle/11577/145782
RCSB PDB - 3AMY: Crystal structure of human CK2 alpha complexed with apigeninRCSB PDB - 3AMY: Crystal structure of human CK2 alpha complexed with apigenin
Casein kinase II subunit alpha. A. 340. Homo sapiens. Mutation(s): 0 Gene Names: CSNK2A1, CK2A1. EC: 2.7.11.1. ...
https://www.rcsb.org/structure/3AMY
Frontiers | Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectivesFrontiers | Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives
... casein kinase 1α (CK1α) and glycogen synthase kinase-3β (GSK-3β) mediates the destruction of cytoplasmically localized β- ... casein kinase 1α; Dsh, Disheveled; Fz, frizzled; GSK-3β, glycogen synthase kinase 3β; LRP, low density lipoprotein receptor ... Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent ... Thorpe, C. J., and Moon, R. T. (2004). nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish ...
https://www.frontiersin.org/articles/10.3389/fphys.2014.00386/full
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue | Nature...Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue | Nature...
REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc. Natl. Acad. Sci. USA 110, 11005-11010 (2013). ... their kinases (name as "kinases") and their downstream regulated interaction partners (named as "regulated"). Shades of gray of ... Wagih, O., Reimand, J. & Bader, G. D. MIMP: predicting the impact of mutations on kinase-substrate phosphorylation. Nat. ... For instance, ATF2 and MEF2A were also associated with angiogenesis and thermogenesis because their upstream kinases were ...
https://www.nature.com/articles/s41467-018-07453-x?error=cookies_not_supported&code=c28fe8b9-e260-4197-af33-1eeb2ee0c81c
Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinaseRole of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase
... the identification of substrate amino acids that are critical to phosphorylation by the kinase a … ... The beta-adrenergic receptor kinase (beta-ARK) phosphorylates G protein coupled receptors in an agonist-dependent manner. Since ... Comparing a variety of kinases, only rhodopsin kinase and casein kinase II exhibited significant phosphorylation of the acidic ... Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase Biochemistry. 1991 ...
https://pubmed.ncbi.nlm.nih.gov/1645191/?dopt=Abstract
FAM83C family with sequence similarity 83 member C [Homo sapiens (human)] - Gene - NCBIFAM83C family with sequence similarity 83 member C [Homo sapiens (human)] - Gene - NCBI
The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms. Fulcher LJ, et al. Sci Signal, 2018 May 22. PMID ... enables protein kinase binding IBA Inferred from Biological aspect of Ancestor. more info ...
https://www.ncbi.nlm.nih.gov/gene/128876
Neurodegenerative Diseases | The New York Academy of SciencesNeurodegenerative Diseases | The New York Academy of Sciences
Physiological role for casein kinase 1 in glutamatergic synaptic transmission. J. Neurosci. 25: 6601-6609. Full Text. Lee, K. W ... Parkinsons disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc. Natl. Acad. Sci. USA ... Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc. Natl. Acad. ...
https://www.nyas.org/ebriefings/neurodegenerative-diseases/
Search Ageing-Associated Genes in Model OrganismsSearch Ageing-Associated Genes in Model Organisms
Casein Kinase Alpha subunit. Saccharomyces cerevisiae. Anti-Longevity CKA2. 855418. CLA4. CLn Activity dependant. ... Bypass of C Kinase. Saccharomyces cerevisiae. Necessary For Fitness BCK1. 851981. BCS1. ubiquinol-cytochrome c reductase (bc1) ... Carboxy-Terminal domain Kinase. Saccharomyces cerevisiae. Necessary For Fitness 80% CTK1. 856241. CTR1. Copper TRansport. ... Ark family Kinase-Like protein. Saccharomyces cerevisiae. Anti-Longevity 20% AKL1. 851857. AKR1. AnKyrin Repeat-containing ...
https://genomics.senescence.info/genes/search.php?organism=Saccharomyces+cerevisiae&show=4
ALSF Childhood Cancer Research Grants | Page 5 | Alexs Lemonade Stand Foundation for Childhood CancerALSF Childhood Cancer Research Grants | Page 5 | Alex's Lemonade Stand Foundation for Childhood Cancer
Publications | CrickPublications | Crick
Cristina Maria Sirrenberg Cruciat | Esslingen UniversityCristina Maria Sirrenberg Cruciat | Esslingen University
1. Cruciat, C.M. (2014). Casein kinase 1 and Wnt/b-catenin signaling. Curr. Opin. Cell Biol., 31, 46-55. ... RNA Helicase DDX3 is a regulatory subunit of Casein Kinase 1 in Wnt/b-catenin signaling. Science, 339, 1436-1441. ...
https://www.hs-esslingen.de/en/staff/cristina-maria-sirrenberg-cruciat/
PeptidesPeptides
CaM Kinase (5) Casein kinase (2) Caspase (13) Caspase 1 (4) Caspase 3 (5) ...
https://www.eurogentec.com/en/catalog/c135~peptides?catalog_product.ProductAttribute.227=20540
Patricelli MP - Search Results - PubMedPatricelli MP - Search Results - PubMed
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics. Okerberg ES, Hainley A, ... In situ kinase profiling reveals functionally relevant properties of native kinases. Patricelli MP, Nomanbhoy TK, Wu J, Brown H ... Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics. Okerberg ES, ... Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza. Atkins C, Evans CW, Nordin B, Patricelli ...
https://pubmed.ncbi.nlm.nih.gov/?term=Patricelli+MP&cauthor_id=20118634
SERINEEpsilonVitroProteinsConformation-selective casein kinase-1 inRegulatesSubstrateSIGNAL TRANSDUCTIONGenesGlycogenInhibitionBeta-subunit of caseinMutationsGeneInhibitorsEukaryoticInhibitor of protein kinaseAxinCKIIDifferent kinasesPhosphorylatesTyrosine protein kinaseIsoformsEnzymeUbiquitousCreatine kinaseSignalingMammalianPhosphorylation siteProtein PhosphataseRegulationSaccharomycesCheckpointGammaMAPKsRegulatoryCytoplasmicSubunitsPI3KInhibitsPhosphatidylinositolTargets
SERINE15
  • A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. (lookformedical.com)
  • Additional characterization of eIF-5 indicates that purified eIF-5 can be phosphorylated at serine residues in vitro by casein kinase II. (elsevier.com)
  • CK2α is a constitutively active and highly conserved serine/threonine protein kinase that is involved in the regulation of key cellular metabolic pathways and associated with a variety of tumours and cancers. (elsevier.com)
  • The only amino acid residue modified by casein kinase II was serine. (nih.gov)
  • Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9 upon stimulation with growth factors such as insulin has been shown to result in inhibition of GSK-3 kinase activity in mammalian cells ( 10 - 12 ). (aacrjournals.org)
  • The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1. (muni.cz)
  • 12. Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity. (nih.gov)
  • casein kinase II), a multifunctional serine/threonine protein kinase. (labome.org)
  • The casein kinase two complex, CK2, is a ubiquitous serine/threonine kinase complex which plays roles in cell growth and proliferation. (elifesciences.org)
  • CSNK1E is a serine/threonine protein kinase and a member of the casein kinase I protein family. (nih.gov)
  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. (joplink.net)
  • In earlier reports, genetic alterations were identified to be involved in CCA carcinogenesis, including point mutations in p53, B-Raf proto-oncogene serine/threonine kinase and V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( 8 , 9 ). (spandidos-publications.com)
  • Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. (nih.gov)
  • The serine is phosphorylated by casein kinase 2 in in vitro assays. (wustl.edu)
  • Dual phosphorylation of WASP on serine 483 and 484 by casein kinases increase the affinity for the ARP2/3 complex. (ecmbio.com)
Epsilon5
  • We show here that multiple phosphorylation sites within Rec8 as well as two different kinases, casein kinase 1delta/epsilon (CK1delta/epsilon) and Dbf4-dependent Cdc7 kinase (DDK), are required for Rec8 cleavage and meiosis I nuclear division. (ox.ac.uk)
  • casein kinase 1 epsilon [Source:HGN. (gsea-msigdb.org)
  • In mammals, circadian oscillations are generated by a set of genes forming a transcriptional autoregulatory feedback loop: these include: Clock, Bmal1, Per1, Per2, Cry1, Cry2 and Casein kinase 1 epsilon. (nih.gov)
  • An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders. (cdc.gov)
  • We have previously identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt/β-catenin network in embryonic development, where it stimulates Casein kinase 1 epsilon (CK1e). (sfb1324.de)
Vitro7
  • Based on in silico and in vitro data, casein kinase 1 (CK1) was predicted as a candidate for MR phosphorylation. (nih.gov)
  • Protein kinase has been labelled in vitro with 125I and injected back into amphibian oocytes. (umn.edu)
  • Supporting it, in vitro kinase assay demonstrated that CX-4945 inhibited human CK2α much more efficiently than Cka1. (elsevier.com)
  • Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro. (nih.gov)
  • The phosphorylation of Drosophila melanogaster DNA topoisomerase II by purified casein kinase II was characterized in vitro. (nih.gov)
  • It is shown that the BRCA1 C-terminal region can negatively modulate phosphorylation levels of the RNA polymerase II CTD by the Cdk-activating kinase (CAK) in vitro. (semanticscholar.org)
  • Moreover, kinase assays in vitro demonstrate a CKII-dependent increase in the binding of wild-type β-catenin with α-catenin. (biologists.com)
Proteins10
  • Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins. (lookformedical.com)
  • Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression. (lookformedical.com)
  • A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM. (lookformedical.com)
  • Potential part for proteins kinases in rules of bidirectional endoplasmic reticulum-to-Golgi transportation revealed by proteins kinase inhibitor H89. (lunararchives.com)
  • 13. The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms. (nih.gov)
  • By phosphorylating substrate proteins, kinases modify the activity, location and affinities of up to 30% of all cellular proteins, and direct most cellular processes, particularly in signal transduction and co-ordination of complex pathways. (wormbook.org)
  • Casein kinases are characterized by their preferential utilization of acidic proteins such as caseins as substrates. (nih.gov)
  • Members of the casein kinase I protein family have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair, and have been shown to phosphorylate a variety of proteins, including itself. (nih.gov)
  • Aprataxin, aprataxin and PNKP-like factor (APLF) and polynucleotide kinase phosphatase (PNKP) are key DNA-repair proteins with diverse functions but which all contain a homologous forkhead-associated (FHA) domain. (figshare.com)
  • Upon engagement with PD-L1, PD-1 becomes phosphorylated by Src family kinases and transmits a negative costimulatory signal through tyrosine phosphatase proteins to attenuate the strength of T-cell receptor (TCR) signals and downstream signalling pathways such as PTENCPI3KCAKT and RASCMEKCERK. (azd1152.com)
Conformation-selective casein kinase-1 in1
  • PMC free of charge content] [PubMed] [Google Scholar]Mashhoon N, DeMaggio AJ, Tereshko V, Bergmeier SC, Egli M, Hoekstra MF, Kuret J. Crystal framework of the conformation-selective casein kinase-1 inhibitor. (lunararchives.com)
Regulates4
  • Caption: Casein kinase 1 (CK1) regulates PERIOD, a core protein in the biological clock of people. (nih.gov)
  • Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis. (ox.ac.uk)
  • Young's lab has discovered that the enzyme casein kinase 1 (DBT) further regulates the pace of this 24-hour molecular clock by limiting the longevity of the PER protein during each circadian cycle, and especially by removing PER when TIM is absent. (rockefeller.edu)
  • This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. (nih.gov)
Substrate2
  • β-Catenin is a multi-functional cellular component and a substrate for several protein kinases. (biologists.com)
  • Yet, their regulation of kinase activity, substrate selectivity and subcellular localisation has remained a mystery. (silverchair.com)
SIGNAL TRANSDUCTION2
  • Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION. (lookformedical.com)
  • A further 91 subfamilies were found in all three metazoan kinomes, including the tyrosine kinase (TK) group and the TKL group, which mediate much of the complexity of intercellular signal transduction. (wormbook.org)
Genes4
  • Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. (lookformedical.com)
  • Such radiations include genes involved in spermatogenesis, chemosensation, Wnt signaling and FGF receptor-like kinases. (wormbook.org)
  • Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
  • We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
Glycogen6
  • A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. (lookformedical.com)
  • [ 67 , 68 ] In the absence of Wnt ligand, cytoplasmic β-catenin is degraded by a destruction complex that includes Axin, adenomatosis polyposis coli, glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). (medscape.com)
  • (A) In the absence of Wg signaling, the Apc and Axin scaffold presents Arm to Casein Kinase 1 ( CK1 ) and Zeste white 3/Glycogen Synthase Kinase 3beta ( Zw3/GSK ) for phosphorylation. (duke.edu)
  • GlcNAcylation is Thr-58 (see figure), which is also the major phosphorylation site used by glycogen-synthetase-kinase-3 and is the major mutational "hotspot" in human lymphomas. (nih.gov)
  • In a simplified overview of the canonical Wnt/β-Catenin pathway, Wnt binds to its receptors Frizzled and LRP5/6, activating the downstream component Dishevelled, which in turn inhibits Glycogen Synthetase Kinase (GSK-3β), Axin and Adenomatous Polyposis Coli (APC) in the β-Catenin destruction complex. (biomedcentral.com)
  • Muscle mass have a short-term store of power within the form of creatine phosphate which is generated from ATP and may regenerate ATP when needed with creatine kinase Muscle tissues also maintain a storage form of glucose in the type of glycogen Glycogen might be quickly transformed to glucose when energy is required for sustained, powerful contractions. (server-he.de)
Inhibition2
  • 5. Zandomeni R, Zandomeni MC, Shugar D, Weinmann R. (1986) Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription. (guidetoimmunopharmacology.org)
  • found that the nanohybrid was able to successfully deliver EGCG into cancer cells, displaying impressive protein kinase CK2 inhibition comparable to that obtained with the most specific CK2 inhibitor, CX-4945 (5.5 vs. 3 µM). (selleckchem.com)
Beta-subunit of casein1
  • Through a yeast two hybrid assay, it was found that the beta-subunit of casein kinase 2 (CK2) associated with a carboxy-terminal region of BRCA1, and this association was much weaker with the same fragment bearing a missense mutation that has been identified in breast tumors. (semanticscholar.org)
Mutations3
  • Rec8 with phosphomimetic mutations is no longer protected from separase at centromeres and is cleaved even when the two kinases are inhibited. (ox.ac.uk)
  • Casein kinase iδ mutations in familial migraine and advanced sleep phase. (nih.gov)
  • Nearly a decade ago, Ptácek's team showed that affected family members had mutations in an enzyme called casein kinase Iδ (CKIδ). (nih.gov)
Gene3
  • 8. Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin. (nih.gov)
  • Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
  • On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. (joplink.net)
Inhibitors6
  • 2013) Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. (guidetoimmunopharmacology.org)
  • 2012) Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. (guidetoimmunopharmacology.org)
  • Screening for protein kinase CK2 inhibitors of the structural diversity compound library (DTP NCI/NIH) led to the discovery of 4-[(E)-(fluoren-9-ylidenehydrazinylidene)-methyl]benzoic acid (E9). (rcsb.org)
  • Selective inhibitors of protein kinase CK2 with significant cytotoxicity on tumor cells based on a 2-aminothiazole scaffold were described recently. (rcsb.org)
  • 5. Recent Advances in the Development of Casein Kinase 1 Inhibitors. (nih.gov)
  • 15. Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. (nih.gov)
Eukaryotic1
  • Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs). (wormbook.org)
Inhibitor of protein kinase1
  • 2011) Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. (guidetoimmunopharmacology.org)
Axin2
  • This allows polymerization of Dsh and Axin at the plasma membrane, inactivating the kinase complex so that it cannot target Arm for destruction. (duke.edu)
  • Intracellular -catenin amounts are controlled with a complicated made up of axin, casein kinase 1 (CKI)a, and adenomatous polyposis coli (APC). (uitest.info)
CKII3
  • We showed that these extensions are phosphorylated at several sites by host casein kinase II (CKII). (apsnet.org)
  • It inhibits several intracellular signaling pathways, including the mitogen-activated protein kinases (MAPKs), casein kinase II (CKII), and the COP9 signalosome (CSN), in various cell types. (greenmedinfo.com)
  • Here we investigated the interaction of protein kinase CKII (casein kinase II) and β-catenin. (biologists.com)
Different kinases1
Phosphorylates1
Tyrosine protein kinase1
  • In addition, increased expression of cyclooxygenase-2, receptor tyrosine-protein kinase c-erbB-2 and interleukin 6 are considered to be involved in early carcinogenesis in the biliary tract epithelium ( 12 , 13 ). (spandidos-publications.com)
Isoforms4
  • Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING. (lookformedical.com)
  • Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA. (lookformedical.com)
  • Recent studies have indicated that the DUF1669 domain mediates the interaction with different isoforms of the CK1 (casein kinase 1) family of Ser/Thr protein kinases. (silverchair.com)
  • One of the first protein kinases to be discovered, the CK1 isoforms are thought to be constitutively active and are known to control a plethora of biological processes. (silverchair.com)
Enzyme3
  • In the latest paper, Partch and her colleagues focused on two core clock components: an enzyme known as casein kinase 1 (CK1) and a protein called PERIOD. (nih.gov)
  • A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. (lookformedical.com)
  • Boost interferon response to viruses, including SARS-CoV-2, by inhibiting the expression of casein kinase II (CK2) - CK2 is an enzyme that is fundamental to controlling homeostasis at the cellular level. (lounewton.com)
Ubiquitous1
  • A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. (lookformedical.com)
Creatine kinase1
Signaling11
  • A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. (lookformedical.com)
  • KA reduced inflammatory replies by downregulating AP-1, NF-B, and JAK/STAT signaling in Rapamycin small molecule kinase inhibitor LPS-induced macrophages and DSS-induced colitis mice. (casein-kinase.info)
  • 14. Casein kinase 1 and Wnt/β-catenin signaling. (nih.gov)
  • 20. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. (nih.gov)
  • This makes kinase signaling particularly amenable to comparative studies, and kinase activity a particularly good readout of the physiological state of any cell. (wormbook.org)
  • 2020. A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells. . (ncbs.res.in)
  • Activin receptor-like kinase 4 (ALK4) is a type I transforming growth factor-β (TGF-β) superfamily receptor that mediates signaling for several TGF-β superfamily ligands, including activin, Nodal and GDF5. (duke.edu)
  • Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. (duke.edu)
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. (duke.edu)
  • Our unpublished work indicates that other members of the 44 DEAD-box RNA helicases can also function as kinase regulators in Wnt signaling. (sfb1324.de)
  • Accumulating evidence indicates that various growth signals and cytokines, such as the insulin-like growth factor-1, the HER-2/neu tyrosine kinase and the Wnt/β-Catenin signaling pathways [ 10 - 13 ], can stimulate the transcriptional activity of the AR. (biomedcentral.com)
Mammalian2
  • Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition. (expasy.org)
  • 9. Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression. (nih.gov)
Phosphorylation site1
  • Topology prediction showed that there is one protein kinase C phosphorylation site, one casein kinase II phosphorylation site, five N-myristoylation sites, and one ATP synthase c subunit signature in the ATP5G1 protein of the giant panda. (geneticsmr.com)
Protein Phosphatase1
  • 2014 ) Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. (neurotree.org)
Regulation2
  • A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. (lookformedical.com)
  • Adducin promotes assembly of spectrin -actin complexes, and is a target for regulation by calmodulin, protein kinase C, and rho kinase. (labome.org)
Saccharomyces1
  • Distribution of 212 kinase subfamilies throughout four kinomes: the yeast Saccharomyces cerevisiae , the nematode worm Caenorhabditis elegans , the fruit fly Drosophila melanogaster and human. (wormbook.org)
Checkpoint1
Gamma1
MAPKs1
  • MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. (joplink.net)
Regulatory1
  • Studies are under way to evaluate the effects of glycosylation on kinase activity and subcellular trafficking of this regulatory protein. (nih.gov)
Cytoplasmic1
  • Part of the labelled casein kinase II is associated with free cytoplasmic informosomes. (umn.edu)
Subunits2
  • Casein kinase II has been isolated from ribosome-free extracts of Rana temporaria oocytes by chromatography on heparin-sepharose, phosphocellulose and mono Q. It consists of different subunits with molecular weights 43, 41 and 29 Kda. (umn.edu)
  • Casein kinase 2 is a heterotetrameric protein kinase, made up of 2 β subunits with two other subunits of α and/or α' composition. (guidetoimmunopharmacology.org)
PI3K1
  • XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases. (adooq.com)
Inhibits2
  • Furthermore, we found that pyrvinium failed to decrease β-catenin protein level and activity in casein kinase 1α (CK1α)-depleted clear cell RCC cells, demonstrating that pyrvinium inhibits β-catenin in a CK1α-dependent manner. (biocytogen.com)
  • Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. (nih.gov)
Phosphatidylinositol1
  • PubMed] [Google Scholar]Jones DH, Morris JB, Morgan CP, Kondo H, Irvine RF, Cockcroft S. Type I phosphatidylinositol 4-phosphate 5-kinase straight interacts with ADP-ribosylation element I and is in charge of phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi area. (lunararchives.com)
Targets2
  • Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. (joplink.net)
  • Their primary binding targets are casein kinase 2-phosphorylated forms of the XRCC1 and XRCC4 scaffold molecules which respectively coordinate single-stranded and double-stranded DNA break repair pathways. (figshare.com)
3wik.1 | SWISS-MODEL Template Library
3wik.1 | SWISS-MODEL Template Library (swissmodel.expasy.org)
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma (medscape.com)
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma (medscape.com)
Figure 1 - Novel Borna Virus in Psittacine Birds with Proventricular Dilatation Disease - Volume 14, Number 12-December 2008 -...
Figure 1 - Novel Borna Virus in Psittacine Birds with Proventricular Dilatation Disease - Volume 14, Number 12-December 2008 -... (wwwnc.cdc.gov)
Detecting Kinase Activity Across the Kinome
Detecting Kinase Activity Across the Kinome (promega.com)
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue | Nature...
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue | Nature... (nature.com)
Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression | BMC Medicine |...
Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression | BMC Medicine |... (bmcmedicine.biomedcentral.com)
Frontiers | Pleiotropic Roles of ChSat4 in Asexual Development, Cell Wall Integrity Maintenance, and Pathogenicity in...
Frontiers | Pleiotropic Roles of ChSat4 in Asexual Development, Cell Wall Integrity Maintenance, and Pathogenicity in... (frontiersin.org)
Neurodegenerative Diseases | The New York Academy of Sciences
Neurodegenerative Diseases | The New York Academy of Sciences (nyas.org)
Search Ageing-Associated Genes in Model Organisms
Search Ageing-Associated Genes in Model Organisms (genomics.senescence.info)
Biomolecules | Free Full-Text | Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts
Biomolecules | Free Full-Text | Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts (mdpi.com)
Publications | Crick
Publications | Crick (crick.ac.uk)
Peptides
Peptides (eurogentec.com)
Csnk2a1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog
Csnk2a1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog (xenbase.org)
Nakamura, Y.<...
Nakamura, Y.<... (research-information.bris.ac.uk)
Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε<...
Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε<... (pennstate.pure.elsevier.com)
Permalien vers (EN) Pascal Marchand
Permalien vers (EN) Pascal Marchand (research.pasteur.fr)
Prof. Dr. biol.hum. Knippschild | Universitätsklinikum Ulm
Prof. Dr. biol.hum. Knippschild | Universitätsklinikum Ulm (uniklinik-ulm.de)
Two phosphoglucomutase paralogs regulate triggered secretion of the Toxoplasma micronemes | bioRxiv
Two phosphoglucomutase paralogs regulate triggered secretion of the Toxoplasma micronemes | bioRxiv (biorxiv.org)
Dr Fatima Labeed | University of Surrey
Dr Fatima Labeed | University of Surrey (surrey.ac.uk)
Dr. Marc Flajolet | Fisher Center for Alzheimer's Research Foundation
Dr. Marc Flajolet | Fisher Center for Alzheimer's Research Foundation (alzinfo.org)
Abstracts - FIP - International Pharmaceutical Federation
Abstracts - FIP - International Pharmaceutical Federation (fip.org)
Abstracts - FIP - International Pharmaceutical Federation
Abstracts - FIP - International Pharmaceutical Federation (fip.org)
Abstracts - FIP - International Pharmaceutical Federation
Abstracts - FIP - International Pharmaceutical Federation (fip.org)
Abstracts - FIP - International Pharmaceutical Federation
Abstracts - FIP - International Pharmaceutical Federation (fip.org)