Cartilage Oligomeric Matrix Protein: Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.Matrilin Proteins: PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Achondroplasia: An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)Research Support, U.S. Gov't, Non-P.H.S.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Research Support, U.S. Gov't, P.H.S.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Osteochondrodysplasias: Abnormal development of cartilage and bone.Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Synovitis: Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Wrist Joint: The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Collagen Type IX: A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.HandbooksManuals as Topic: Books designed to give factual information or instructions.BooksIn Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Cartoons as Topic: Images used to comment on such things as contemporary events, social habits, or political trends; usually executed in a broad or abbreviated manner.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Research Support, Non-U.S. Gov'tResearch Support, U.S. GovernmentResearch Support, American Recovery and Reinvestment ActResearch Support, N.I.H., ExtramuralResearch Support, N.I.H., IntramuralCamels: Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.Fibroblast Growth Factor 2: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).Fibroblast Growth Factors: A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.Receptors, Fibroblast Growth Factor: Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.Fibroblast Growth Factor 1: A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).Receptor, Fibroblast Growth Factor, Type 1: A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.Receptor, Fibroblast Growth Factor, Type 2: A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).Horses: Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Procollagen N-Endopeptidase: An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Thrombospondin 1: An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)25-Hydroxyvitamin D3 1-alpha-Hydroxylase: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. (1/201)

Cartilage matrix protein (CMP; also known as matrilin-1), one of the major noncollagenous proteins in most cartilages, binds to aggrecan and type II collagen. We examined the effect of CMP on the adhesion of chondrocytes and fibroblasts using CMP-coated dishes. The CMP coating at 10-20 micrograms/ml enhanced the adhesion and spreading of rabbit growth plate, resting and articular chondrocytes, and fibroblasts and human epiphyseal chondrocytes and MRC5 fibroblasts. The effect of CMP on the spreading of chondrocytes was synergistically increased by native, but not heated, type II collagen (gelatin). The monoclonal antibody to integrin alpha1 or beta1 abolished CMP-induced cell adhesion and spreading, whereas the antibody to integrin alpha2, alpha3, alpha5, beta2, alpha5beta1, or alphaVbeta5 had little effect on cell adhesion or spreading. The antibody to integrin alpha1, but not to other subunits, coprecipitated 125I-CMP that was added to MRC5 cell lysates, indicating the association of CMP with the integrin alpha1 subunit. Unlabeled CMP competed for the binding to integrin alpha1 with 125I-CMP. These findings suggest that CMP is a potent adhesion factor for chondrocytes, particularly in the presence of type II collagen, and that integrin alpha1beta1 is involved in CMP-mediated cell adhesion and spreading. Since CMP is expressed almost exclusively in cartilage, this adhesion factor, unlike fibronectin or laminin, may play a special role in the development and remodeling of cartilage.  (+info)

Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts. (2/201)

OBJECTIVE: Cartilage oligomeric matrix protein (COMP) is a large disulfide-linked pentameric protein. Each of its five subunits is approximately 100,000 Da in molecular weight. COMP was originally identified and characterized in cartilage and it has been considered a marker of cartilage metabolism because it is currently thought not to be present in other joint tissues, except for tendon. To confirm the tissue specificity of COMP expression we examined cultured human dermal fibroblasts, human foreskin fibroblasts, and normal human synovial cells for the synthesis of COMP in culture. METHOD: Normal synovial cells and normal human dermal foreskin fibroblasts were isolated from the corresponding tissues by sequential enzymatic digestions and cultured in media containing 10% fetal bovine serum until confluent. During the final 24 h of culture, the cells were labeled with 35S-methionine and 35S-cysteine in serum- and cysteine/methionine-free medium. The newly synthesized COMP molecules were immunoprecipitated from the culture media with a COMP-specific polyclonal antiserum, or with monoclonal antibodies or affinity-purified COMP antibodies. The immunoprecipitated COMP was analyzed by electrophoresis in 5.5% polyacrylamide gels. For other experiments, synovial cells cultured from the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were similarly examined. RESULTS: A comparison of the amounts of COMP produced by each cell type (corrected for the DNA content) revealed that synovial cells produced > or = 9 times more COMP than chondrocytes or dermal fibroblasts. COMP could be easily detected by immunoprecipitation in all cell types. Electrophoretic analysis revealed a distinct band with an apparent MW of 115-120 kDa in samples from each of the three cell types, regardless of the antibody used. COMP expression in cultures of synoviocytes derived from OA and RA patients showed that OA and RA synovial cells produced similar amounts of monomeric COMP of identical size to those COMP monomers produced by normal synovial cells. The addition of TGF-beta to these cultures resulted in an increase in COMP production in normal, OA and RA synovial cells (45, 116 and 115% respectively). CONCLUSION: These studies demonstrate that substantial amounts of COMP are produced by several mesenchymal cells including synoviocytes and dermal fibroblasts. These findings raise important concerns regarding the utility of measurements of COMP levels in serum or in synovial fluid as markers of articular cartilage degradation because of the likelihood that a substantial proportion of COMP or COMP fragments present in serum or synovial fluid may be produced by cells other than articular chondrocytes.  (+info)

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. (3/201)

OBJECTIVE: To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip and knee osteoarthritis (OA), and to examine the potential utility of COMP as a diagnostic biomarker for knee OA. METHODS: Serum samples and knee and hip radiographs were obtained at a baseline evaluation as part of the Johnston County Osteoarthritis Project, a population-based study of OA in rural North Carolina. A total of 291 Caucasian participants were randomly selected for COMP analysis, 143 patients with radiographic knee OA (Kellgren/Lawrence [K/L] grade > or = 2) and 148 controls with neither hip nor knee OA (K/L grade 0), evenly distributed by age and gender. COMP was quantified by competitive enzyme-linked immunosorbent assay with monoclonal antibody 17-C10. The natural log-transformed COMP data were analyzed using general linear models. RESULTS: Serum COMP levels were significantly elevated (P = 0.0001) in the age > or = 65 group (mean +/- SD 1,302.1 +/- 496.7 ng/ml) versus the age 45-54 and age 55-64 groups (1,058.1 +/- 432.4 and 1,038.6 +/- 313.3, respectively). Serum COMP levels of the OA group were significantly higher than those of the control group (1,208.57 +/- 487.47 ng/ml versus 1,061.83 +/- 370.58 ng/ml; P = 0.0093). Serum COMP levels also increased significantly with knee OA K/L grade (P = 0.0047), knee OA laterality (P = 0.0043), and number of knee and hip joints involved (P = 0.0001). There was no significant difference in serum COMP levels by gender or obesity. CONCLUSION: We demonstrate that in a population-based sample, serum COMP levels can distinguish an OA-affected subgroup from an unaffected subgroup and can reflect disease severity and multiple joint involvement in OA.  (+info)

A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain. (4/201)

Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin family of extracellular matrix glycoproteins. All members of the family contain a highly conserved region of thrombospondin type 3 sequence repeats that bind calcium. A mutation in COMP previously identified in a patient with pseudoachondroplasia resulted in abnormal sequestration of COMP in distinctive rER vesicles. The mutation, Asp-446 --> Asn, is located in the type 3 repeats of the molecule. This region was expressed in a mammalian culture with and without the mutation to study the structural or functional properties associated with the mutation. The biophysical parameters of the mutant peptide were compared with those of the wild type and revealed the following difference: secondary structural analysis by circular dichroism showed more alpha-helix content in the wild-type peptides. The calcium binding properties of the two peptides were significantly different; there were 17 calcium ions bound/wild-type COMP3 peptide compared with 8/mutant peptide. In addition, wild-type COMP3 had a higher affinity for calcium and bound calcium more cooperatively. Calcium bound by the wild-type peptide was reflected in a structural change as indicted by velocity sedimentation. Thus, the effect of the COMP mutation appears to profoundly alter the calcium binding properties and may account for the difference observed in the structure of the type 3 domain. Furthermore, the highly cooperative binding of calcium to COMP3 suggests that these type 3 sequence repeats form a single protein domain, the thrombospondin type 3 domain.  (+info)

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. (5/201)

Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue-specific antigen. One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin-1.  (+info)

Molecular cloning and expression patterns of mouse cartilage oligomeric matrix protein gene. (6/201)

OBJECTIVE: To develop transgenic mice harboring mutations in the COMP gene as animal models for pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), autosomal dominant disorders characterized by early onset osteoarthritis and epiphyseal abnormalities. As a first step in generating a mouse model for COMP mutations, we have cloned the cDNA of mouse COMP and examined its tissue expression pattern. DESIGN: Total mRNA was isolated from the skeletal tissues of newborn C57BL/6j mice and used as a template for oligo(dT) first-strand cDNA synthesis. The cDNA was used for PCR amplification of COMP using three oligonucleotide primer pairs designed from the published rat COMP cDNA sequence. Nested PCR was used to complete the sequence between the amplified fragments. The entire cDNA was sequenced and the expression pattern of the corresponding transcripts examined by Northern hybridizations. RESULTS: A full-length COMP cDNA was isolated. Analysis showed that the entire translated region of the mouse COMP gene is 2268 bp and the derived amino acid sequence shows 90% homology to human COMP. Of eight adult mouse non-cartilage tissues tested, COMP expression was detected only in testis.  (+info)

Pseudoachondroplastic dysplasia: an Iowa review from human to mouse. (7/201)

Lamellar inclusions of the rough endoplasmic reticulum in growth plate chondrocytes, first identified (1972) in the Department of Orthopaedic Surgery, University of Iowa, has become the cytochemical hallmark for the pseudoachondroplastic dysplasia (PSACH) phenotype, linking an endoplasmic reticulum storage disorder with the osteochondrodysplasia. Since this original observation, great advances have been made, leading to the molecular understanding of this altered longitudinal bone growth anomaly. A PSACH canine model suggested that abatement of cumulative vertical growth of growth plate chondrocytes seen in PSACH results from (1) altered extracellular matrix constraints for horizontal growth and (2) uncoupling of endochondral and perichondral growth that causes metaphyseal flaring. PSACH, an autosomal dominant disease, is linked to mutation of the cartilage oligomeric matrix protein (COMP) gene. Amino acid substitutions, deletions, or additions is proposed to alter COMP structure that cause its retention in the rough endoplasmic reticulum of growth plate chondrocytes, leading to (1) compositional and structural change of the extracellular matrix, and (2) altered cellular proliferation and volume expansion. Normal growth and development occurs in COMP gene knockout mice that do not synthesis COMP, demonstrating that a mutant COMP, not absence of COMP, is required for the PSACH phenotype. The mechanism by which mutant COMP induces a PSACH phenotype remains to be elucidated. At the University of Iowa a cell culture system has been developed whereby mutant COMP transgenes are introduced into chondrocytes and the expressed product COMP is retained in the endoplasmic reticulum. This readily manipulated system makes it possible to decipher systematically the system's cellular secretory processing pathway, in order to clarify the mechanism(s) by which the mutant COMP is retained within the endoplasmic reticulum. Concurrent with this is the development of transgenic mice expressing the mutant COMP used in the cell culture system. This will make it possible to establish that expression of a human PSACH-linked mutant COMP will produce a PSACH phenotype. A PSACH animal model will provide a means to characterize the mechanism of altered longitudinal bone growth and to test gene therapy approaches for correcting the anomaly.  (+info)

Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. (8/201)

Mutations in residues in the type 3 calcium-binding repeats and COOH-terminal globular region of cartilage oligomeric matrix protein (COMP) lead to two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia. It has been hypothesized that these mutations cause COMP to misfold and to be retained in the endoplasmic reticulum. However, this hypothesis is not supported by previous reports that COMP, when purified in the presence of EDTA, shows no obvious difference in electron microscopic appearance in the presence or absence of calcium ions. Since this discrepancy may be due to the removal of calcium during purification, we have expressed wild-type COMP and the most common mutant form found in pseudoachondroplasia, MUT3, using a mammalian expression system and have purified both proteins in the presence of calcium. Both proteins are expressed as pentamers. Direct calcium binding experiments demonstrate that wild-type COMP, when purified in the presence of calcium, is a calcium-binding protein. Rotary shadowing electron microscopy and limited trypsin digestion at various calcium concentrations show that there are conformational changes associated with calcium binding to COMP. Whereas COMP exists in a more compact conformation in the presence of calcium, it shows a more extended conformation when calcium is removed. MUT3, with a single aspartic acid deletion in the type 3 repeats, binds less calcium and presents an intermediate conformation between the calcium-replete and calcium-depleted forms of COMP. In conclusion, we show that a single mutation in the type 3 repeats of COMP causes the mutant protein to misfold. Our data demonstrate the importance of calcium binding to the structure of COMP and provide a plausible explanation for the observation that mutations in the type 3 repeats and COOH-terminal globular region lead to pseudoachondroplasia.  (+info)

*Cartilage oligomeric matrix protein

... (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ... "Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... "Entrez Gene: COMP cartilage oligomeric matrix protein". Paulsson M, Heinegård D (Aug 1981). "Purification and structural ... Rosenberg K, Olsson H, Mörgelin M, Heinegård D (Aug 1998). "Cartilage oligomeric matrix protein shows high affinity zinc- ...

*Multiple epiphyseal dysplasia

2002). "Cartilage oligomeric matrix protein-deficient mice have normal skeletal development". Mol Cell Biol. 22 (12): 4366-71. ... 1995). "Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene ... "COMP cartilage oligomeric matrix protein [ Homo sapiens (human) ]". "MATN3 matrilin 3 [ Homo sapiens (human) ]". d Briggs, ... Paulsson M, Heinegård D (1981). "Purification and structural characterization of a cartilage matrix protein". Biochem J. 197 (2 ...

*Pseudoachondroplasia

The cartilage oligomeric matrix protein is 757 aa (OMIM 2008). COMP protein is found in the extracellular matrix, a complex web ... Pseudoachondroplasia is caused by a heterozygous mutation in the gene encoding cartilage oligomeric matrix protein COMP. ... "Serum or plasma cartilage oligomeric matrix protein concentration as a diagnostic marker in pseudoachondroplasia: differential ... We do not yet fully understand the normal function of COMP protein, though it is believed to play a part in cellular growth, ...

*ADAMTS12

2006). "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein". J. Biol. Chem. 281 (23): 15800-8. doi: ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ... Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ...

*ADAMTS7

This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. ADAMTS7 has been associated ... a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein". FASEB journal: official ... This 1686-amino acid protein belongs to the ADAMTS family and is one of 19 members known in humans. As an ADAMTS protein, ... participate in the protein's tight interaction with the extracellular matrix. ADAMTS7 was identified in a yeast two-hybrid ...

*MMP19

2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1- ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the ... "Entrez Gene: MMP19 matrix metallopeptidase 19". Murphy G, Knäuper V, Cowell S, et al. (1999). "Evaluation of some newer matrix ...

*MMP20

2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1- ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... and contains more protein and water. In general, MMP-20 functions in enamel are to cleave enamel matrix proteins at specific ... "Entrez Gene: MMP20 matrix metallopeptidase 20 (enamelysin)". Moradian-Oldak J (2012). "Protein-mediated enamel mineralization ...

*Proteoglycan 4

"Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent interactions ... The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin". Journal of Colloid and Interface ... When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now ... Lubricins unglycosylated regions can interact cartilage proteins. This characteristic may aid in the molecule's boundary ...

*Collagen, type IX, alpha 1

... interaction with glycosaminoglycans and cartilage oligomeric matrix protein". J. Biol. Chem. 279 (23): 24265-73. doi:10.1074/ ... Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. This gene encodes one of the three alpha ... Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule". Matrix Biol. 17 (3): 237-41. doi: ... Diab M, Wu JJ, Eyre DR (1996). "Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking ...

*ZBTB7A

... interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. ... Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene. ZBTB7A has been ... ZBTB7A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) FactorBook ZBTB7A This article ... Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327-35. ...

*CKM (gene)

Kim HJ, Lee YH, Kim CK (2009). "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in ... The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein ... 2008). "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis". J. Mol. Biol. ... Li S, Bai JH, Park YD, Zhou HM (2006). "Capture of monomeric refolding intermediate of human muscle creatine kinase". Protein ...

*Gene therapy for osteoarthritis

... cartilage oligomeric matrix protein, bone morphogenetic protein, and other anabolic gene candidates are among the candidate ... OA is mostly the result of natural aging of the joint due to biochemical changes in the cartilage extracellular matrix. ... Genes, which contribute to protect and restore the matrix of articular cartilage, are attracting the most attention. These ... 2005). "Transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage ...

*Comp

... , COMP or Comps may refer to: Cartilage oligomeric matrix protein Comparettia, an orchid genus comp (command), a command in ...

*Chromosome 19 (human)

Cartilage oligomeric matrix protein. Gene map locus 19p13.1 NOTCH3: Notch homolog 3 (Drosophila): Gene map locus 19p13.1-p13.2 ... encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger ... encoding protein Zinc finger protein 180 ZNF208: encoding protein Zinc finger protein 208 ZNF224: encoding protein Zinc finger ... encoding protein Zinc finger protein 225 ZNF226: encoding protein Zinc finger protein 226 ZNF229: encoding protein Zinc finger ...

*Thrombospondin

... also designated cartilage oligomeric protein or COMP). TSP-1 and -2 are homotrimers, consisting of three identical subunits, ... Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the ... "Matricellular proteins and biomaterials". Matrix Biology. 37: 183-191. doi:10.1016/j.matbio.2014.03.002. PMC 4167162 . PMID ... As such, TSP-1 is designated a multifunctional protein. TSP-1 has multiple receptors, among which CD36, CD47 and integrins are ...

*Tenascin C

Other extracellular matrix components such as matrix metalloproteins and integrins are also frequently co-expressed with TN-C. ... These protein modules are lined up like beads on a string and give rise to long and extended molecules. At the N-terminus each ... Tenascin C is an oligomeric glycoprotein composed of individual polypeptides with molecular weights ranging from 180 to ~300kDa ... bone and cartilage. The human tenascin C gene, TN-C, is located on chromosome 9 with location of the cytogenic band at the 9q33 ...

*Elastin like polypeptides

Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of ... Concatamers are oligomeric products of ligating a single gene with itself. This will result in repeat segments of a gene, all ... ELP networks to promote cell growth may prove indispensable in the production of tissue scaffolds that promote cartilage ... ELPs can be engineered to recognize specific proteins in solution. The protein purification aspect of ELPs is supported by the ...

*Osteoarthritis

... as a prognostic marker for knee osteoarthritis progression and serum cartilage oligomeric protein (COMP) levels as a prognostic ... the collagen matrix becomes more disorganized and there is a decrease in proteoglycan content within cartilage. The breakdown ... a) cartilage erosion (b)cartilage ulceration (c)cartilage repair (d)osteophyte (bone spur) formation. Histopathology of ... The capsule and fluid protect the cartilage, muscles, and connective tissues. With osteoarthritis, the cartilage becomes worn ...

*Beta-catenin

DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... Axin is then titrated away from its oligomeric assemblies - the β-catenin destruction complex - by Dsh. Once bound to the ... They also produce extracellular matrix components, such as type I collagen and fibronectin. Aberrant activation of the Wnt ... "Researchers Offer First Direct Proof of How Arthritis Destroys Cartilage" at rochester.edu Human CTNNB1 genome location and ...
CONTEXT AND OBJECTIVE: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women. MATERIALS AND METHODS: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up. RESULTS: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33-2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared. DISCUSSION AND CONCLUSION: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and
OBJECTIVE:,br /,To test the hypothesis that physiological cyclic loading during a 30-min walking exercise causes an increase in serum cartilage oligomeric matrix protein (COMP) concentration in a healthy population.,br /,METHODS:,br /,Blood samples (5 ml) were drawn from 10 physically active adults immediately before and after, and 0.5h, 1.5h, 3.5h and 5.5h after a 30-min walking exercise on a level outdoor walking track at self-selected normal speed. On a separate day, blood samples were drawn from the same 10 subjects during 6h while they were resting in a chair. Serum COMP concentrations were determined using a commercial enzyme-linked immunosorbent assay (COMP ELISA). An activity monitor was used to record basic time-distance measurements of gait. Serum COMP concentrations within the exercise protocol and within the resting protocol were compared using separate repeated measures analyses of variance (alpha=0.05).,br /,RESULTS:,br /,In the exercise protocol, a first increase (9.7%; P=0.003) ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Until now, nothing has been known about the role of COMP during human development. COMP has been shown to be located in porcine joints, where high levels were seen in the proliferating zones and low levels were seen in the hypertrophic zones [5], which differs from what we found for human embryonic development. During human bone development investigated here, the strongest staining for COMP was seen in areas where joint development had taken place. This differs from mouse development, in which COMP is seen mainly in the perichondrium, but is in line with the present results, which demonstrate COMP-positive hypertrophic cartilage zones also during human development [27]. We were able to show COMP-positive superficial cartilage zones, as already described for mice [24]. Additionally, we detected COMP in the middle zones and in deep cartilage zones near the tidemark. Furthermore, COMP was detected in the basement membrane zones of the AER, the earliest signs of limb bud formation, but not in the ...
Osteoarthritis Cartilage. 2011 Oct;19(10):1246-53. doi: 10.1016/j.joca.2011.07.011. Epub 2011 Jul 29. Research Support, Non-U.S. Govt
Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
Results Clinical scores were significantly reduced after IL-18 blockade (rhIL-18BP 1 mg/kg, p , 0.001, n = 13; anti-IL18 IgG, 2 mg, p , 0.05, n = 9, Mann Whitney test, treated versus placebo groups). Histological examination showed cartilage protection (decrease erosion scores, p , 0.05) that was accompanied by significantly reduced levels of serum cartilage oligomeric matrix protein (an indicator of cartilage turnover) and VDIPEN expression (a neoepitope present after digestion by matrix metalloproteinases). X-ray analysis of joints provided evidence of reduced bone erosion. ...
Both GH and IGF-I stimulate bone growth, but the molecular mechanisms mediating their effects on the growth plate are not fully understood. We measured gene expression by microarray analysis in primary cultured human chondrocytes treated with either GH or IGF-I. One of the genes found to be up-regulated by both GH and IGF-I was that encoding cartilage oligomeric matrix protein (COMP). This protein is predominantly found in the extracellular matrix of cartilage. Mutations in the COMP gene have been associated with syndromes of short stature. To verify that COMP is regulated by GH in vivo, we measured COMP levels in serum in short children treated with GH. The study included 113 short prepubertal children (14 girls and 99 boys) with a mean (+/- sd) age of 8.84 +/- 2.76 yr, height sd score of -2.74 +/- 0.67, and IGF-I sd score of -1.21 +/- 1.07 at the start of GH administration. Serum levels of COMP were 1.58 +/- 0.28, 1.83 +/- 0.28 (P < 0.0001), 1.91 +/- 0.28 (P < 0.0001), 1.78 +/- 0.28 (P < ...
Complete information for COMP gene (Protein Coding), Cartilage Oligomeric Matrix Protein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint. Immunohistochemical analysis of human cartilage biopsies showed lubricin and COMP co-localise to the cartilage surface. COMP knockout mice, however, presented with a lubricin layer on the articular cartilage leading to the further investigation of additional lubricin binding mechanisms. Proximity ligation assays (PLA) on human cartilage biopsies was used to localise additional lubricin ...
Two distinct IL-18 neutralizing strategies, i.e. a rabbit polyclonal anti-mouse IL-18 IgG and a recombinant human IL-18 binding protein (rhIL-18BP), were used to treat collagen-induced-arthritic DBA/1 mice after clinical onset of disease. The therapeutic efficacy of neutralizing endogenous IL-18 was assessed using different pathological parameters of disease progression. The clinical severity in mice undergoing collagen-induced arthritis was significantly reduced after treatment with both IL-18 neutralizing agents compared to placebo treated mice. Attenuation of the disease was associated with reduced cartilage erosion evident on histology. The decreased cartilage degradation was further documented by a significant reduction in the levels of circulating cartilage oligomeric matrix protein (an indicator of cartilage turnover). Both strategies efficiently slowed disease progression, but only anti-IL-18 IgG treatment significantly decreased an established synovitis. Serum levels of IL-6 were ...
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) is an enzyme that in humans is encoded by the ADAMTS7 gene on chromosome 15. It is ubiquitously expressed in many tissues and cell types. This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. ADAMTS7 has been associated with cancer and arthritis in multiple tissue types. The ADAMTS7 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. The ADAMTS7 gene resides on chromosome 15 at the band 15q24.2 and contains 25 exons. This 1686-amino acid protein belongs to the ADAMTS family and is one of 19 members known in humans. As an ADAMTS protein, ADAMTS7 contains a shared proteinase domain and an ancillary domain. The proteinase domain can be further divided into a signal peptide, a prodomain, a metalloproteinase domain, and a disintegrin-like domain. In particular, the metalloproteinase domain contains a cysteine-switch motif in its binding site ...
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair ...
Background. Peritubular capillary injury induces chronic hypoxia in the renal tubulointerstitium, and renal peritubular capillary dysfunction is an early event that contributes to tubulointerstitial fibrosis. Cyclosporine A (CsA) is a potent immunosuppressant and improves survival of renal allografts. However, the limitation of CsA use is chronic nephrotoxicity. A soluble, stable and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1 has been developed. We investigated whether COMP-Ang1 ameliorates CsA-induced renal injury.. Methods. CsA-treated mice were injected with recombinant adenovirus expressing either COMP-Ang1 or LacZ. Histology, inflammatory, haemodynamic and fibrotic parameters, and signalling pathway were evaluated.. Results. Histologic examination showed that COMP-Ang1 significantly decreased CsA-induced tubular damage and tubulointerstitial fibrosis. CsA-induced increases in macrophage infiltration and expression of MCP-1 and ICAM-1 after CsA ...
article{a79f8280-0e9f-4f33-82c9-d5b574133dd0, abstract = {We present a novel animal model for rheumatoid arthritis induced with a well defined synthetic adjuvant oil, pristane. Two weeks after a single intradermal injection of 150 microliters of pristane, the rats developed severe and chronic arthritis. The inflammation was restricted to the joints and involved pannus formation, major histocompatibility complex (MHC) class II expression, and T lymphocyte infiltration. The initial development as well as the chronic stage of pristane-induced arthritis was ameliorated by treatment with antibodies to the alpha beta-T-cell receptor showing that the disease is T cell dependent. Increased levels of interleukin in serum was seen after pristane injection but not during the chronic stage of arthritis. Joint erosions were accompanied by elevated serum levels of cartilage oligomeric matrix protein. Comparison of MHC congenic LEW strains showed that the severity and chronicity of arthritis varied among the ...
article{8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe, abstract = {OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms. ,br, ,br, METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation. ,br, ,br, RESULTS The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p<0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory ...
Complete information for MATN4 gene (Protein Coding), Matrilin 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Ashfaq UA, Javed T, Rehman S, Nawaz Z, RiazuddinS. Lysosomotropic agents as HCV entry inhibitors. Virol J. 2011; 8: 163-68. Brondello JM, Philipot D, Djouad F, Jorgensen C, Noël D. Cellular senescence is a common characteristic shared by preneoplasic and osteo-arthritic tissue. Open Rheumatol J. 2010; 4: 10-14. Cawston T, Billington C, Cleaver C, Elliott S, Hui W, Koshy P, Shingleton B, Rowan A. The regulation of MMPs and TIMPs in cartilage turnover. Ann NY Acad Sci. 1999; 878: 120-29. Costedoat-Chalumeau N, Leroux G, Piette J-P, AmouraZ. Why all systemic lupus erythematosus patients should begiven hydroxychloroquine treatment? Joint Bone Spine. 2010; 77: 4-5. Eyre D. Collagen of articular cartilage. Arthritis Res. 2002; 4: 30-35. Gentili C, Cancedda R. Cartilage and bone extracellular matrix. Curr Pharm Des 2009; 15: 1334-48. Guzman-Morales J, Lafantaisie-Favreau CH, Chen G, Hoemann CD. Subchondral chitosan/blood implant-guided bone plate resorption and woven bone repair is coupled to hya-line ...
Up to now, COMP is the only gene known to be associated with pseudoachondroplasia. COMP mutations and pathological consequences have been extensively studied in Caucasians, but a few in the Chinese population. Besides the c.815C→T in exon 8 [19] and the c.1447-1455del [20] in exon 13 of COMP gene reported lately in Chinese PSACH patients, we identified the c. 1352_1353insTGTCCCTGG within exon 13 of COMP that contributes to severe PSACH phenotype in a Han Chinese pedigree. This novel trinucleotide expansion was located in the region coding the sixth CLR (p. 451V_452PinsVPG) and expands the knowledge of COMP mutations leading to PSACH.. PSACH mutations are located in exons 8-14 of COMP gene encoding the type III CLRs of COMP protein [3, 18, 28]. The most frequent mutation, present in one third of PSACH patients, is the deletion of GAC (c.1405-1419delGAC) in a very short triplet repeat (GAC5), which encodes five consecutive aspartic acid residues within the CLR7 of the protein, usually referred ...
Individuals affected with pseudoachondroplasia are similar in height as those with achondroplasia, but their head size is the same as that of average-sized people. They also lack the facial features of patients with achondroplasia. It usually goes undiagnosed until the child is 2 to 3 years old.
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The ever-growing energy consumption in mobile networks stimulated by the expected growth in data tra ffic has provided the impetus for mobile operators to refocus network design, planning and deployment towards reducing the cost per bit, whilst at the same time providing a signifi cant step towards reducing their operational expenditure. As a step towards incorporating cost-eff ective mobile system, 3GPP LTE-Advanced has adopted the coordinated multi-point (CoMP) transmission technique due to its ability to mitigate and manage inter-cell interference (ICI). Using CoMP the cell average and cell edge throughput are boosted. However, there is room for reducing energy consumption further by exploiting the inherent exibility of dynamic resource allocation protocols. To this end packet scheduler plays the central role in determining the overall performance of the 3GPP longterm evolution (LTE) based on packet-switching operation and provide a potential research playground for optimizing energy ...
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slow comp - posted in Virus, Spyware, Malware Removal: my comp keeps goin slow i run ad-aware scan which i will post it gives it puts the nasties in quarantine do i delete these or is it just best to leave them ArchiveData(auto-quarantine- 2005-10-20 20-36-31.bckp) Referencefile : SE1R71 19.10.2005 ====================================================== MRU LIST obj[0...
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Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to…
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IDENTIFICATION DIVISION. PROGRAM-ID. COMPARE. ENVIRONMENT DIVISION. DATA DIVISION. WORKING-STORAGE SECTION. 01 USERID PIC X(11) VALUES "SAMP/SAMP". 01 BLOB1 SQL-BLOB. 01 BLOB2 SQL-BLOB. 01 BUFFER2 PIC X(32767) VARYING. 01 RET PIC S9(9) COMP. 01 AMT PIC S9(9) COMP. 01 POS PIC S9(9) COMP VALUE 1024. 01 OFFSET PIC S9(9) COMP VALUE 1. EXEC SQL VAR BUFFER2 IS VARRAW(32767) END-EXEC. EXEC SQL INCLUDE SQLCA END-EXEC. PROCEDURE DIVISION. COMPARE-BLOB. EXEC SQL WHENEVER SQLERROR DO PERFORM SQL-ERROR END-EXEC. EXEC SQL CONNECT :USERID END-EXEC. * Allocate and initialize the BLOB locators: EXEC SQL ALLOCATE :BLOB1 END-EXEC. EXEC SQL ALLOCATE :BLOB2 END-EXEC. EXEC SQL WHENEVER NOT FOUND GOTO END-OF-BLOB END-EXEC. EXEC SQL SELECT FRAME INTO :BLOB1 FROM MULTIMEDIA_TAB M WHERE M.CLIP_ID = 1 END-EXEC. EXEC SQL SELECT FRAME INTO :BLOB2 FROM MULTIMEDIA_TAB M WHERE M.CLIP_ID = 2 END-EXEC. * Open the BLOBs for READ ONLY: EXEC SQL LOB OPEN :BLOB1 READ ONLY END-EXEC. EXEC SQL LOB OPEN :BLOB2 READ ONLY END-EXEC. * ...
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There seems to be a theme building for our success. If things are stressful and break the routine, then we tend to do pretty good. This last competition was no exception. This past weekend we competed in Orion, IL and was suppose to be a pretty relaxing comp. It was scheduled in a way that we…
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COMP Full-Length MS Protein Standard (NP_000086), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
List of AI-related FAQs from Carnegie-Mellon Note that comp.ai is now moderated so your post may not show up for a while and if it doesnt fit the moderators idea of what is appropriate it will not show up at all. Its a fact of life that many people interested in AI do not like philosophical discussions because such discussions never settle anything and in fact comp.ai.philosophy was created so that those discussions would not clutter up comp.ai. Since posters did not voluntarily follow the guidelines the readers of comp.ai voted to moderate the group to keep out off-topic and frivolous posts. For the most part comp.ai.philosophy considers the original goal of AI, technical details of systems are few and the discussion centers around definitions of terms, the means that will be required for producing a general purpose intelligence like a human being and even whether or not it can be done at all. Also dont forget that Dejanews lists discussions from all newsgroups, if its an answer you want it ...
Methods Meta-analysis of genome-wide association studies was applied to standardised residuals of sCOMP (N=3316) and uCTX-II (N=4654) levels available in 6 and 7 studies, respectively, from TreatOA. Effects were estimated using a fixed-effects model. Six promising signals were followed up by de novo genotyping in the Cohort Hip and Cohort Knee study (N=964). Subsequently, their role in OA susceptibility was investigated in large-scale genome-wide association studies meta-analyses for OA. Differential expression of annotated genes was assessed in cartilage.. ...
The aggrecan concentrations as well as the aggrecan/COMP ratios decreased during progression of the destruction in the destructive group, which corroborates previous results from cross sectional studies.17 18 Thus we find striking changes in the release of aggrecan during development of destruction, whereas the COMP levels seem to vary little. This contrasts findings in a cross sectional study, where slightly, but significantly, lower concentrations of COMP were seen in patients with advanced destruction.19 The reasons for this discrepancy is at present unclear. The BSP concentrations in the destructive group increased during progression of destruction, which corroborates and extends the observations from our previous cross sectional study.22 It should be noted that the concentrations of BSP did not differ between the groups at initiation of the study and no clinical usefulness of BSP in predicting individual susceptibility is therefore apparent.. The longitudinal changes of the synovial fluid ...
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The present study was conducted to assess the anti-rheumatic therapeutic potential of IL-18 neutralization, by investigating the effect of blocking endogenous IL-18 in an experimental model of rheumatoid arthritis. Two distinct IL-18 neutralizing reagents were administered therapeutically to mice with CIA. Our results clearly demonstrate that blocking endogenous IL-18 after disease onset significantly decreases the clinical symptoms of arthritis, and, more importantly, that this therapeutic approach protects joints from further destruction. The disease-modifying property of the treatment was demonstrated by a significant decrease in cartilage erosion scores and reduction of the levels of COMP in the serum. Neutralization of IL-18 with the antibody, at the single concentration investigated, consistently and significantly reduced all parameters studied, i.e., visual clinical scores, paw swelling, cartilage degradation, levels of serum COMP, and IL-6.. A dose-finding study using rhIL-18BP revealed ...
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Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. {ECO:0000269,PubMed:11084047, ECO:0000269,PubMed:11565064, ECO:0000269,PubMed:21922596, ECO:0000269,PubMed:7670472, ECO:0000269,PubMed:9021009, ECO:0000269,PubMed:9184241, ...
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Quantikine® ELISA kit for human COMP/Thrombospondin-5 (Cat#DCMP0). 0.036 ng/mL detection sensitivity. View COMP/Thrombospondin-5 ELISA kit details.
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A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Multiple epiphyseal dysplasia 6
Author: Armeanu, S. et al.; Genre: Journal Article; Published in Print: 2005-10-15; Title: Severe impairment of dendritic cell allostimulatory activity by Sendai virus vectors is overcome by matrix protein gene deletion
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Al-Gazali and Bakalinova (1998) described a multiply consanguineous Omani family in the UAE, in which four out of the 13 children presented with symptoms of macrocephaly, frontal lobe atrophy, and distinctive facial appearance. The first case was a boy. CT scan of his brain in his few months showed slightly dilated lateral ventricles. He had a squint in the left eye, which was operated upon. His developmental milestones were delayed, and by the age of 10-years, he showed increased swelling of the upper and lower limbs, particularly around the elbows, macrocephaly with frontal bossing, hypertelorism, flat malar regions, low set ears, short neck, and slight pectus excavatum. All joints were prominent, and there was non-pitting edema of lower limbs. Both testes were undescended. Skeletal survey showed a big skull with dysplasia of the epiphyses of the long bones. The patients sister showed the same dysmorphic features. Non-pitting edema in her case involved the entire lower limbs, including the ...
In the present investigation we show that CHAD, a relatively abundant noncollagenous protein in cartilage extracellular matrix, interacts with β1 integrins on bovine chondrocytes. This interesting finding identifies CHAD as a candidate for mediating signals between the chondrocytes and the cartilage matrix.. CHAD is a member of the LRR protein family (35). Among other members in this family are the small cartilage proteoglycans biglycan, decorin, fibromodulin, and lumican. These proteoglycans are all known to interact with collagen (18, 41, 47), but it is not known if CHAD interacts with collagen or other matrix molecules.. Chondrocyte adhesion to CHAD was partially inhibited by a rat polyclonal antibody against β1 integrin. Species differences between cells and antibodies may explain why the inhibition was not total. Alternatively, other receptors than β1 integrins may also be involved in the adhesion to CHAD. We found that adhesion of chondrocytes to CHAD was dependent on Mg2+ or Mn2+ but ...

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based...Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based...

We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... CONTEXT AND OBJECTIVE: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 ...
more infohttps://oacentre.kennedy.ox.ac.uk/publications/599383

Cartilage oligomeric matrix protein - WikipediaCartilage oligomeric matrix protein - Wikipedia

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ... "Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... "Entrez Gene: COMP cartilage oligomeric matrix protein". Paulsson M, Heinegård D (Aug 1981). "Purification and structural ... Rosenberg K, Olsson H, Mörgelin M, Heinegård D (Aug 1998). "Cartilage oligomeric matrix protein shows high affinity zinc- ...
more infohttps://en.wikipedia.org/wiki/Cartilage_oligomeric_matrix_protein

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancerCartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen ... Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen ... Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen ... Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Englund, E LU ; Bartoschek ...
more infohttps://lup.lub.lu.se/search/publication/ee475f9a-8fab-4cbf-9d82-1bdbe6637f2d

RCSB PDB 









- 1FBM: ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN IN COMPLEX WITH ALL-TRANS RETINOL...RCSB PDB - 1FBM: ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN IN COMPLEX WITH ALL-TRANS RETINOL...

... vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage ... Assembly domain of cartilage oligomeric matrix protein Assembly domain of cartilage oligomeric matrix protein Assembly domain ... Assembly domain of cartilage oligomeric matrix protein Assembly domain of cartilage oligomeric matrix protein Assembly domain ... Assembly domain of cartilage oligomeric matrix protein Assembly domain of cartilage oligomeric matrix protein Assembly domain ...
more infohttp://www.rcsb.org/pdb/explore/derivedData.do?structureId=1FBM

Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene....Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene....

Osteoarthritis Cartilage. 2011 Oct;19(10):1246-53. doi: 10.1016/j.joca.2011.07.011. Epub 2011 Jul 29. Research Support, Non-U.S ... Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene. ... Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene ... Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/21843649

Value of Entheseal Ultrasonography and Serum Cartilage Oligomeric Matrix Protein in the Preclinical Diagnosis of Psoriatic...Value of Entheseal Ultrasonography and Serum Cartilage Oligomeric Matrix Protein in the Preclinical Diagnosis of Psoriatic...

Hedbom E, Antonsson P, Hjerpe A. Cartilge matrix proteins. An Acidic oligomeric protein (COMP) detected only in cartilage. J ... Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... Cartilage oligomeric matrix protein (COMP): A biomarker of arthritis. Biomarker Insight. 2009;4:33-44. [PMC free article] [ ... The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Current Drug Targets. 2008;9(10):869-77. [PubMed] ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC2989640/

Molecular synergy in biolubrication : The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricinMolecular synergy in biolubrication : The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin

We suggest that cartilage oligomeric matrix protein (COMP) is one of the biomolecules that promotes anchoring of lubricin in a ... Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... We suggest that our findings can be extrapolated to cartilage surfaces, where co-localization of COMP and lubricin has been ...
more infohttp://kth.diva-portal.org/smash/record.jsf?pid=diva2:1090546

Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With...Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With...

Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α7β ... Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α7β ... Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α7β ... Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With ...
more infohttp://circres.ahajournals.org/content/early/2009/12/17/CIRCRESAHA.109.202762

High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with...High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with...

Objective. To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in ... High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with ... High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with ... High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with ...
more infohttp://www.jrheum.org/content/36/6/1126

Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course...Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course...

We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti- ... Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course ... Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course ... Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course ...
more infohttp://www.jrheum.org/content/early/2011/05/12/jrheum.101241

The early diagnostic value of serum neopterin and cartilage oligomeric matrix protein for osteoarticular changes among...The early diagnostic value of serum neopterin and cartilage oligomeric matrix protein for osteoarticular changes among...

Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis. Biomark Insights. 2009;4:33-44. PubMedPubMedCentral ... Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology ... Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and ... Meanwhile, cartilage oligomeric matrix protein (COMP) and neopterin (NPT) levels in all samples were measured simultaneously ...
more infohttps://www.springermedizin.de/the-early-diagnostic-value-of-serum-neopterin-and-cartilage-olig/16097056

Gentaur Molecular :Biovend \ Human, Cartilage Oligomeric Matrix Protein CHO , Rec. Prot. \ RGB002Gentaur Molecular :Biovend \ Human, Cartilage Oligomeric Matrix Protein CHO , Rec. Prot. \ RGB002

Cartilage Oligomeric Matrix Protein CHO , Rec. Prot. \ RGB002 for more molecular products just contact us ... Cartilage Oligomeric Matrix Protein CHO , Rec. Prot.. Related products : Human, Cartilage Oligomeric Matrix Protein CHO , Rec. ... Cartilage Oligomeric Matrix Protein CHO , Rec. Prot. / Product Detail : RGB002 Human, Cartilage Oligomeric Matrix Protein CHO ... Cartilage oligomeric matrix protein (COMP), also designated thrombospondin 5 (TSP 5), is non-collagenous glycoprotein and is a ...
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Buy Recombinant Human Cartilage Oligomeric Matrix Protein, HEK ProteinBuy Recombinant Human Cartilage Oligomeric Matrix Protein, HEK Protein

HEK Protein from Prospec cat# pro-132. ProteoGenix provides you the best Recombinant proteins. Shop now from our 200 000 + ... Buy online Recombinant Human Cartilage Oligomeric Matrix Protein, ... More info about Recombinant Human Cartilage Oligomeric Matrix Protein, HEK Protein. Catalog#: pro-132. ... Data sheet of Recombinant Human Cartilage Oligomeric Matrix Protein, HEK Protein. Brand. Prospec. ...
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Anti COMP (Cartilage Oligomeric Matrix Protein)Anti COMP (Cartilage Oligomeric Matrix Protein)

... Monoclonal antibody. Background. COMP - Cartilage oligomeric matrix protein is ... HOME / CONTENTS / Antibodies / Research Antibodies / Bone-Related Research / Anti COMP (Cartilage Oligomeric Matrix Protein) ... Anti COMP (Cartilage Oligomeric Matrix Protein) monoclonal antibody [CAC-PRPG-CP-M01] ... Fragments of COMP have been detected in the diseased cartilage, synovial fluid, and serum of patients with knee injuries, post- ...
more infohttps://www.cosmobio.com/contents/cac_20111026.html

Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin ... ? Cartilage Oligomeric Matrix Protein - [PDF Document]Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin ... ? Cartilage Oligomeric Matrix Protein - [PDF Document]

1 Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin-4 (TSP-4) and type I and III Collagens in tendon An ... Chondrocytes Cartilage Matrix In vivo Chondrocytes Cartilage Matrix In vitro Chondrocytes Cartilage Matrix NatureNumico Model ... Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin-4 (TSP-4) and type I and III Collagens in tendon An ... Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin-4 (TSP-4) and type I and III Collagens in tendon ...
more infohttps://vdocuments.mx/cartilage-oligomeric-matrix-protein-comp-thrombospondin-cartilage-oligomeric.html

Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by...Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by...

... degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from ... RESULTS IL-1alpha stimulation of cartilage resulted in a fragmentation of COMP, which was inhibited by MMP inhibitors CGS ... METHODS COMP fragments were generated in vitro by treating (a) bovine articular cartilage with interleukin-1alpha (IL-1alpha ... Isolated, recombinant MMPs rapidly degraded purified COMP, as well as COMP residing in cartilage. Several COMP fragments ...
more infohttps://www.semanticscholar.org/paper/Inhibition-of-interleukin-1alpha-induced-cartilage-Ganu-Goldberg/47e2a0c79e28f167c6d8fa6605924d88f5c10d24

Cartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee OsteoarthritisCartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee Osteoarthritis

Serum cartilage oligomeric matrix protein (COMP) and serum Hyaluronic acid (HA) are the two diagnostic biomarkers which are ... Li H, Wang D, Wu ZQ, Zhong JM, Yuan YJ (2012) Serum levels of cartilage oligomeric matrix protein in the diagnosis of knee ... 2011) Cartilage oligomeric matrix protein - inflammation biomarker in knee osteoarthritis. Bosn J Basic Med Sci 11(1): 27-32. ... Aims & Objectives: The aim of the study is to assess role of serum Cartilage oligomeric matrix protein (COMP) and serum ...
more infohttps://medcraveonline.com/MOJOR/MOJOR-02-00044

Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adultsSerum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ... Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ... Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ... Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ...
more infohttps://kops.uni-konstanz.de/handle/123456789/17895

Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C | bdd | ENCartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C | bdd | EN

Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C Andreasson K., ... Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we ...
more infohttp://www.echosensclinicallibrary.com/cartilage-oligomeric-matrix-protein-a-new-promising-biomarker-of-liver-fibrosis-in-chronic-hepatitis-c

Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in...Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in...

Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in ... both of which are caused by mutations in the cartilage oligomeric matrix protein (COMP) gene. Therefore, COMP may be a ... is a common cause of musculoskeletal disability characterized by late-onset degeneration of articular cartilage. Although ... Cartilage/chemistry*. *Cartilage Oligomeric Matrix Protein. *Cross-Sectional Studies. *Extracellular Matrix Proteins/genetics* ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=1934

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based...Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based...

We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ...
more infohttps://www.kennedy.ox.ac.uk/publications/599383

COMP Gene - GeneCards | COMP Protein | COMP AntibodyCOMP Gene - GeneCards | COMP Protein | COMP Antibody

Protein Coding), Cartilage Oligomeric Matrix Protein, including: function, proteins, disorders, pathways, orthologs, and ... Protein Symbol:. P49747-COMP_HUMAN. Recommended name:. Cartilage oligomeric matrix protein Protein Accession:. P49747. ... Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. ( ... COMP (Cartilage Oligomeric Matrix Protein) is a Protein Coding gene. Diseases associated with COMP include Pseudoachondroplasia ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=COMP

Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas - 1st EditionHandbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas - 1st Edition

Cartilage Oligomeric Matrix Protein CDKN2A Cyclooxygenase-2 Cysteine-Rich Secretory Protein-. Cystic Fibrosis Transmembrane ... Protein Block Buffer Detergent Wash Buffer Methods Immunohistochemistry for Bcl-2 and Hepatocyte Protein Materials Preparation ... Inhibitor of Differentiation and DNA Binding Protein LKB1 Gene Metastatic Tumor Antigen1 Mitogen-Activated Protein Kinase 17p ... Id Protein Integrin Interleukin-8 KOC K-ras Gene Maspin Metastasis-Associated Gene 1 Microvascular Density Mucins Neurokinin-1 ...
more infohttps://www.elsevier.com/books/handbook-of-immunohistochemistry-and-in-situ-hybridization-of-human-carcinomas/hayat/978-0-12-088404-9

Biomarker Menu - Pacific BiomarkersBiomarker Menu - Pacific Biomarkers

COMP (Cartilage Oligomeric Matrix Protein). Analyte: Cartilage Oligomeric Matrix Protein. Specimen Type: Serum,EDTA Plasma ... Cartilage Oligomeric Matrix Protein (COMP) is a non-collagen protein in the matrix of articular cartilage (1). COMP has a ... HMGB1 (high mobility group box1 protein) is an approximately 30 kDa protein that is the major component of the non-histone ... Biomarker Category: Cartilage Diseases and Arthritis. Anti-CCP (Anti-Cyclic Citrullinated Peptide). Analyte: Anti-Cyclic ...
more infohttps://pacbio.com/biomarker/category/21/
  • Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene. (nih.gov)
  • Cartilage and bone metabolism in rheumatoid arthritis. (wikipedia.org)
  • Conclusion Our study provides additional evidence for the existence of different disease pathways in anti-CCP-positive and anti-CCP-negative subsets of RA, and evidence that anti-CCP antibodies may be implicated in the disease process by modifying cartilage metabolism. (jrheum.org)
  • In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). (plos.org)
  • Increased serum levels of cartilage oligomeric matrix protein in patients with psoriasis vulgaris: a marker for unknown peripheral joint involvement? (semanticscholar.org)
  • Degeneration to the tendon extracellular matrix (ECM) often precedes rupture and a high cyclic load is most likely an important factor explaining its high incidence in racing horses. (vdocuments.mx)
  • The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. (jrheum.org)
  • Pregnancy-Associated Plasma Protein-A and its Role in Cardiovascular Disease. (benthamscience.com)
  • Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). (genecards.org)