Cartilage oligomeric matrix protein. Medical search

Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.

PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.

Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).

An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

Abnormal development of cartilage and bone.

A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.

A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.

A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.

A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Polymorphic cells that form cartilage.

A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.

The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.

A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.

Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.

Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.

Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.

Injuries to the knee or the knee joint.

The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.

Glycoproteins which have a very high polysaccharide content.

The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.

A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Pathological processes involving the chondral tissue (CARTILAGE).

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. (1/201)

Cartilage matrix protein (CMP; also known as matrilin-1), one of the major noncollagenous proteins in most cartilages, binds to aggrecan and type II collagen. We examined the effect of CMP on the adhesion of chondrocytes and fibroblasts using CMP-coated dishes. The CMP coating at 10-20 micrograms/ml enhanced the adhesion and spreading of rabbit growth plate, resting and articular chondrocytes, and fibroblasts and human epiphyseal chondrocytes and MRC5 fibroblasts. The effect of CMP on the spreading of chondrocytes was synergistically increased by native, but not heated, type II collagen (gelatin). The monoclonal antibody to integrin alpha1 or beta1 abolished CMP-induced cell adhesion and spreading, whereas the antibody to integrin alpha2, alpha3, alpha5, beta2, alpha5beta1, or alphaVbeta5 had little effect on cell adhesion or spreading. The antibody to integrin alpha1, but not to other subunits, coprecipitated 125I-CMP that was added to MRC5 cell lysates, indicating the association of CMP with the integrin alpha1 subunit. Unlabeled CMP competed for the binding to integrin alpha1 with 125I-CMP. These findings suggest that CMP is a potent adhesion factor for chondrocytes, particularly in the presence of type II collagen, and that integrin alpha1beta1 is involved in CMP-mediated cell adhesion and spreading. Since CMP is expressed almost exclusively in cartilage, this adhesion factor, unlike fibronectin or laminin, may play a special role in the development and remodeling of cartilage. (+info)

Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts. (2/201)

OBJECTIVE: Cartilage oligomeric matrix protein (COMP) is a large disulfide-linked pentameric protein. Each of its five subunits is approximately 100,000 Da in molecular weight. COMP was originally identified and characterized in cartilage and it has been considered a marker of cartilage metabolism because it is currently thought not to be present in other joint tissues, except for tendon. To confirm the tissue specificity of COMP expression we examined cultured human dermal fibroblasts, human foreskin fibroblasts, and normal human synovial cells for the synthesis of COMP in culture. METHOD: Normal synovial cells and normal human dermal foreskin fibroblasts were isolated from the corresponding tissues by sequential enzymatic digestions and cultured in media containing 10% fetal bovine serum until confluent. During the final 24 h of culture, the cells were labeled with 35S-methionine and 35S-cysteine in serum- and cysteine/methionine-free medium. The newly synthesized COMP molecules were immunoprecipitated from the culture media with a COMP-specific polyclonal antiserum, or with monoclonal antibodies or affinity-purified COMP antibodies. The immunoprecipitated COMP was analyzed by electrophoresis in 5.5% polyacrylamide gels. For other experiments, synovial cells cultured from the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were similarly examined. RESULTS: A comparison of the amounts of COMP produced by each cell type (corrected for the DNA content) revealed that synovial cells produced > or = 9 times more COMP than chondrocytes or dermal fibroblasts. COMP could be easily detected by immunoprecipitation in all cell types. Electrophoretic analysis revealed a distinct band with an apparent MW of 115-120 kDa in samples from each of the three cell types, regardless of the antibody used. COMP expression in cultures of synoviocytes derived from OA and RA patients showed that OA and RA synovial cells produced similar amounts of monomeric COMP of identical size to those COMP monomers produced by normal synovial cells. The addition of TGF-beta to these cultures resulted in an increase in COMP production in normal, OA and RA synovial cells (45, 116 and 115% respectively). CONCLUSION: These studies demonstrate that substantial amounts of COMP are produced by several mesenchymal cells including synoviocytes and dermal fibroblasts. These findings raise important concerns regarding the utility of measurements of COMP levels in serum or in synovial fluid as markers of articular cartilage degradation because of the likelihood that a substantial proportion of COMP or COMP fragments present in serum or synovial fluid may be produced by cells other than articular chondrocytes. (+info)

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. (3/201)

OBJECTIVE: To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip and knee osteoarthritis (OA), and to examine the potential utility of COMP as a diagnostic biomarker for knee OA. METHODS: Serum samples and knee and hip radiographs were obtained at a baseline evaluation as part of the Johnston County Osteoarthritis Project, a population-based study of OA in rural North Carolina. A total of 291 Caucasian participants were randomly selected for COMP analysis, 143 patients with radiographic knee OA (Kellgren/Lawrence [K/L] grade > or = 2) and 148 controls with neither hip nor knee OA (K/L grade 0), evenly distributed by age and gender. COMP was quantified by competitive enzyme-linked immunosorbent assay with monoclonal antibody 17-C10. The natural log-transformed COMP data were analyzed using general linear models. RESULTS: Serum COMP levels were significantly elevated (P = 0.0001) in the age > or = 65 group (mean +/- SD 1,302.1 +/- 496.7 ng/ml) versus the age 45-54 and age 55-64 groups (1,058.1 +/- 432.4 and 1,038.6 +/- 313.3, respectively). Serum COMP levels of the OA group were significantly higher than those of the control group (1,208.57 +/- 487.47 ng/ml versus 1,061.83 +/- 370.58 ng/ml; P = 0.0093). Serum COMP levels also increased significantly with knee OA K/L grade (P = 0.0047), knee OA laterality (P = 0.0043), and number of knee and hip joints involved (P = 0.0001). There was no significant difference in serum COMP levels by gender or obesity. CONCLUSION: We demonstrate that in a population-based sample, serum COMP levels can distinguish an OA-affected subgroup from an unaffected subgroup and can reflect disease severity and multiple joint involvement in OA. (+info)

A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain. (4/201)

Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin family of extracellular matrix glycoproteins. All members of the family contain a highly conserved region of thrombospondin type 3 sequence repeats that bind calcium. A mutation in COMP previously identified in a patient with pseudoachondroplasia resulted in abnormal sequestration of COMP in distinctive rER vesicles. The mutation, Asp-446 --> Asn, is located in the type 3 repeats of the molecule. This region was expressed in a mammalian culture with and without the mutation to study the structural or functional properties associated with the mutation. The biophysical parameters of the mutant peptide were compared with those of the wild type and revealed the following difference: secondary structural analysis by circular dichroism showed more alpha-helix content in the wild-type peptides. The calcium binding properties of the two peptides were significantly different; there were 17 calcium ions bound/wild-type COMP3 peptide compared with 8/mutant peptide. In addition, wild-type COMP3 had a higher affinity for calcium and bound calcium more cooperatively. Calcium bound by the wild-type peptide was reflected in a structural change as indicted by velocity sedimentation. Thus, the effect of the COMP mutation appears to profoundly alter the calcium binding properties and may account for the difference observed in the structure of the type 3 domain. Furthermore, the highly cooperative binding of calcium to COMP3 suggests that these type 3 sequence repeats form a single protein domain, the thrombospondin type 3 domain. (+info)

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. (5/201)

Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue-specific antigen. One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin-1. (+info)

Molecular cloning and expression patterns of mouse cartilage oligomeric matrix protein gene. (6/201)

OBJECTIVE: To develop transgenic mice harboring mutations in the COMP gene as animal models for pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), autosomal dominant disorders characterized by early onset osteoarthritis and epiphyseal abnormalities. As a first step in generating a mouse model for COMP mutations, we have cloned the cDNA of mouse COMP and examined its tissue expression pattern. DESIGN: Total mRNA was isolated from the skeletal tissues of newborn C57BL/6j mice and used as a template for oligo(dT) first-strand cDNA synthesis. The cDNA was used for PCR amplification of COMP using three oligonucleotide primer pairs designed from the published rat COMP cDNA sequence. Nested PCR was used to complete the sequence between the amplified fragments. The entire cDNA was sequenced and the expression pattern of the corresponding transcripts examined by Northern hybridizations. RESULTS: A full-length COMP cDNA was isolated. Analysis showed that the entire translated region of the mouse COMP gene is 2268 bp and the derived amino acid sequence shows 90% homology to human COMP. Of eight adult mouse non-cartilage tissues tested, COMP expression was detected only in testis. (+info)

Pseudoachondroplastic dysplasia: an Iowa review from human to mouse. (7/201)

Lamellar inclusions of the rough endoplasmic reticulum in growth plate chondrocytes, first identified (1972) in the Department of Orthopaedic Surgery, University of Iowa, has become the cytochemical hallmark for the pseudoachondroplastic dysplasia (PSACH) phenotype, linking an endoplasmic reticulum storage disorder with the osteochondrodysplasia. Since this original observation, great advances have been made, leading to the molecular understanding of this altered longitudinal bone growth anomaly. A PSACH canine model suggested that abatement of cumulative vertical growth of growth plate chondrocytes seen in PSACH results from (1) altered extracellular matrix constraints for horizontal growth and (2) uncoupling of endochondral and perichondral growth that causes metaphyseal flaring. PSACH, an autosomal dominant disease, is linked to mutation of the cartilage oligomeric matrix protein (COMP) gene. Amino acid substitutions, deletions, or additions is proposed to alter COMP structure that cause its retention in the rough endoplasmic reticulum of growth plate chondrocytes, leading to (1) compositional and structural change of the extracellular matrix, and (2) altered cellular proliferation and volume expansion. Normal growth and development occurs in COMP gene knockout mice that do not synthesis COMP, demonstrating that a mutant COMP, not absence of COMP, is required for the PSACH phenotype. The mechanism by which mutant COMP induces a PSACH phenotype remains to be elucidated. At the University of Iowa a cell culture system has been developed whereby mutant COMP transgenes are introduced into chondrocytes and the expressed product COMP is retained in the endoplasmic reticulum. This readily manipulated system makes it possible to decipher systematically the system's cellular secretory processing pathway, in order to clarify the mechanism(s) by which the mutant COMP is retained within the endoplasmic reticulum. Concurrent with this is the development of transgenic mice expressing the mutant COMP used in the cell culture system. This will make it possible to establish that expression of a human PSACH-linked mutant COMP will produce a PSACH phenotype. A PSACH animal model will provide a means to characterize the mechanism of altered longitudinal bone growth and to test gene therapy approaches for correcting the anomaly. (+info)

Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. (8/201)

Mutations in residues in the type 3 calcium-binding repeats and COOH-terminal globular region of cartilage oligomeric matrix protein (COMP) lead to two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia. It has been hypothesized that these mutations cause COMP to misfold and to be retained in the endoplasmic reticulum. However, this hypothesis is not supported by previous reports that COMP, when purified in the presence of EDTA, shows no obvious difference in electron microscopic appearance in the presence or absence of calcium ions. Since this discrepancy may be due to the removal of calcium during purification, we have expressed wild-type COMP and the most common mutant form found in pseudoachondroplasia, MUT3, using a mammalian expression system and have purified both proteins in the presence of calcium. Both proteins are expressed as pentamers. Direct calcium binding experiments demonstrate that wild-type COMP, when purified in the presence of calcium, is a calcium-binding protein. Rotary shadowing electron microscopy and limited trypsin digestion at various calcium concentrations show that there are conformational changes associated with calcium binding to COMP. Whereas COMP exists in a more compact conformation in the presence of calcium, it shows a more extended conformation when calcium is removed. MUT3, with a single aspartic acid deletion in the type 3 repeats, binds less calcium and presents an intermediate conformation between the calcium-replete and calcium-depleted forms of COMP. In conclusion, we show that a single mutation in the type 3 repeats of COMP causes the mutant protein to misfold. Our data demonstrate the importance of calcium binding to the structure of COMP and provide a plausible explanation for the observation that mutations in the type 3 repeats and COOH-terminal globular region lead to pseudoachondroplasia. (+info)

... (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ... "Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... "Entrez Gene: COMP cartilage oligomeric matrix protein". Paulsson M, Heinegård D (Aug 1981). "Purification and structural ... Rosenberg K, Olsson H, Mörgelin M, Heinegård D (Aug 1998). "Cartilage oligomeric matrix protein shows high affinity zinc- ...

https://en.wikipedia.org/wiki/Cartilage_oligomeric_matrix_protein

2002). "Cartilage oligomeric matrix protein-deficient mice have normal skeletal development". Mol Cell Biol. 22 (12): 4366-71. ... 1995). "Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene ... "COMP cartilage oligomeric matrix protein [ Homo sapiens (human) ]". "MATN3 matrilin 3 [ Homo sapiens (human) ]". d Briggs, ... Paulsson M, Heinegård D (1981). "Purification and structural characterization of a cartilage matrix protein". Biochem J. 197 (2 ...

https://en.wikipedia.org/wiki/Multiple_epiphyseal_dysplasia

The cartilage oligomeric matrix protein is 757 aa (OMIM 2008). COMP protein is found in the extracellular matrix, a complex web ... Pseudoachondroplasia is caused by a heterozygous mutation in the gene encoding cartilage oligomeric matrix protein (COMP). ... "Serum or plasma cartilage oligomeric matrix protein concentration as a diagnostic marker in pseudoachondroplasia: differential ... We do not yet fully understand the normal function of COMP protein, though it is believed to play a part in cellular growth, ...

https://en.wikipedia.org/wiki/Pseudoachondroplasia

2006). "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein". J. Biol. Chem. 281 (23): 15800-8. doi: ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ... Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ...

https://en.wikipedia.org/wiki/ADAMTS12

This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. ADAMTS7 has been associated ... a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein". FASEB Journal. 20 (7): 988-990. ... This 1686-amino acid protein belongs to the ADAMTS family and is one of 19 members known in humans. As an ADAMTS protein, ... participate in the protein's tight interaction with the extracellular matrix. ADAMTS7 was identified in a yeast two-hybrid ...

https://en.wikipedia.org/wiki/ADAMTS7

2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1- ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the ... "Entrez Gene: MMP19 matrix metallopeptidase 19". Murphy G, Knäuper V, Cowell S, et al. (1999). "Evaluation of some newer matrix ...

https://en.wikipedia.org/wiki/MMP19

2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1- ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... and contains more protein and water. In general, MMP-20 functions in enamel are to cleave enamel matrix proteins at specific ... "Entrez Gene: MMP20 matrix metallopeptidase 20 (enamelysin)". Moradian-Oldak J (2012). "Protein-mediated enamel mineralization ...

https://en.wikipedia.org/wiki/MMP20

... interaction with glycosaminoglycans and cartilage oligomeric matrix protein". J. Biol. Chem. 279 (23): 24265-73. doi:10.1074/ ... Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. This gene encodes one of the three alpha ... Wu JJ, Woods PE, Eyre DR (Dec 1992). "Identification of cross-linking sites in bovine cartilage type IX collagen reveals an ... Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule". Matrix Biol. 17 (3): 237-41. doi: ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_1

... is inherited in an autosomal dominant manner and is caused solely by mutations in the cartilage oligomeric matrix protein COMP ... Osteochondrodysplasia is a general term for a disorder of the development (dysplasia) of bone ("osteo") and cartilage ("chondro ... and Arthropathy in two unrelated children with matrix metalloproteinase 2 variants: Genetic-skeletal correlations". Bone ...

https://en.wikipedia.org/wiki/Osteochondrodysplasia

... interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. ... Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene. ZBTB7A has been ... ZBTB7A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) FactorBook ZBTB7A This article ... Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327-35. ...

https://en.wikipedia.org/wiki/ZBTB7A

... non-collagenous extracellular matrix components, including: 3% cartilage oligomeric matrix protein, 1-2% elastin, 1-5% ... Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as ... Collagenous Extracellular Matrix Proteins and Minor Collagens in Tendon". Journal of Orthopaedic Research. 38 (1): 23-35. doi: ... "Elasticity in extracellular matrix 'shape modules' of tendon, cartilage, etc. A sliding proteoglycan-filament model". Journal ...

https://en.wikipedia.org/wiki/Tendon

Kim HJ, Lee YH, Kim CK (2009). "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in ... The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein ... 2008). "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis". J. Mol. Biol. ... Li S, Bai JH, Park YD, Zhou HM (2006). "Capture of monomeric refolding intermediate of human muscle creatine kinase". Protein ...

https://en.wikipedia.org/wiki/CKM_(gene)

... cartilage oligomeric matrix protein, bone morphogenetic protein, and other anabolic gene candidates are among the candidate ... OA is mostly the result of natural aging of the joint due to biochemical changes in the cartilage extracellular matrix. ... Genes, which contribute to protect and restore the matrix of articular cartilage, are attracting the most attention. These ... 2005). "Transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage ...

https://en.wikipedia.org/wiki/Gene_therapy_for_osteoarthritis

... a type of school in the United Kingdom Cartilage oligomeric matrix protein, or COMP Comparettia, an orchid genus Comp cards, ...

https://en.wikipedia.org/wiki/Comp

... and serum cartilage oligomeric matrix protein (COMP) levels as a prognostic marker for incidence of both knee and hip ... a) cartilage erosion (b)cartilage ulceration (c)cartilage repair (d)osteophyte (bone spur) formation. Histopathology of ... The capsule and fluid protect the cartilage, muscles, and connective tissues. With osteoarthritis, the cartilage becomes worn ... the collagen matrix becomes more disorganized and there is a decrease in proteoglycan content within cartilage. The breakdown ...

https://en.wikipedia.org/wiki/Osteoarthritis

Cartilage oligomeric matrix protein. Gene map locus 19p13.1 NOTCH3: Notch homolog 3 (Drosophila): Gene map locus 19p13.1-p13.2 ... encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger ... encoding protein Zinc finger protein 180 ZNF208: encoding protein Zinc finger protein 208 ZNF224: encoding protein Zinc finger ... encoding protein Zinc finger protein 225 ZNF226: encoding protein Zinc finger protein 226 ZNF229: encoding protein Zinc finger ...

https://en.wikipedia.org/wiki/Chromosome_19

... also designated cartilage oligomeric protein or COMP). TSP-1 and TSP-2 are homotrimers, consisting of three identical subunits ... Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the ... "Matricellular proteins and biomaterials". Matrix Biology. 37: 183-191. doi:10.1016/j.matbio.2014.03.002. PMC 4167162. PMID ... As such, TSP-1 is designated a multifunctional protein. TSP-1 has multiple receptors, among which CD36, CD47 and integrins are ...

https://en.wikipedia.org/wiki/Thrombospondin

Other extracellular matrix components such as matrix metalloproteins and integrins are also frequently co-expressed with TN-C. ... These protein modules are lined up like beads on a string and give rise to long and extended molecules. At the N-terminus each ... Tenascin C is an oligomeric glycoprotein composed of individual polypeptides with molecular weights ranging from 180 to ~300kDa ... bone and cartilage. The human tenascin C gene, TN-C, is located on chromosome 9 with location of the cytogenic band at the 9q33 ...

https://en.wikipedia.org/wiki/Tenascin_C

Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of ... Concatamers are oligomeric products of ligating a single gene with itself. This will result in repeat segments of a gene, all ... ELP networks to promote cell growth may prove indispensable in the production of tissue scaffolds that promote cartilage ... In this linear state, the ELP-protein complex cannot easily be distinguished from the extraneous proteins in the solution. ...

https://en.wikipedia.org/wiki/Elastin-like_polypeptides

DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... Axin is then titrated away from its oligomeric assemblies - the β-catenin destruction complex - by Dsh. Once bound to the ... They also produce extracellular matrix components, such as type I collagen and fibronectin. Aberrant activation of the Wnt ... "Researchers Offer First Direct Proof of How Arthritis Destroys Cartilage" at rochester.edu Human CTNNB1 genome location and ...

https://en.wikipedia.org/wiki/Catenin_beta-1

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based ... T1 - Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community- ...

https://research-information.bris.ac.uk/en/publications/serum-cartilage-oligomeric-matrix-protein-and-development-of-radi

To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N- ... Cartilage Oligomeric Matrix Protein, Case-Control Studies, Collagen Type I, Disease Progression, Extracellular Matrix Proteins ... OBJECTIVE: To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum ... Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of ...

https://www.ndorms.ox.ac.uk/publications/107490?1dca9ff4-7097-11ed-853a-06764d77d490

The COMP gene provides the instructions for making the COMP protein. Learn about this gene and related health conditions. ... Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. J ... This protein is found in the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in ... Specifically, the COMP protein is located in the extracellular matrix surrounding the cells that make up ligaments and tendons ...

https://medlineplus.gov/genetics/gene/comp/

Cartilage oligomeric matrix protein (COMP) may be a marker of cartilage destruction. C-reactive protein, hyaluronan, YKL-40, ... The defective genes are often coding for structural proteins of the extracellular matrix of the joint and collagen proteins. ... Autologous cartilage transplantation, where grafts of normal cartilage are taken from the edge of the diseased joint, cultured ... Guidance on the use of autologous cartilage transplantation for full thickness cartilage defects in knee joints. London: NICE, ...

https://pmj.bmj.com/content/79/933/377?ijkey=76b087856ac4917ebd8bece9bdc3b35c73fcb732&keytype2=tf_ipsecsha

Serum cartilage oligomeric matrix protein increases with signs and symptoms of potential pre-radiographic hip and knee ... Serum cartilage oligomeric matrix protein increases with signs and symptoms of potential pre-radiographic hip and knee ... Ethnic and sex differences in serum cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. Arthritis ... Ethnic and sex differences in serum cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. Arthritis ...

https://www.cdc.gov/arthritis/publications/topics.htm

Here, changes in cartilage oligomeric matrix protein (COMP), interleukin-6 (IL-6), and creatine phosphokinase (CPK) were ... Cartilage Oligomeric Matrix Protein; Creatine Phosphokinase; Static Trunk Loading ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&f1=TI&Startyear=&t1=1&s2=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=85&RecNo=841&View=f&

Mutations in the cartilage oligomeric matrix protein (COMP) gene in pseudoachondroplasia and multiple epiphyseal. In: Molecular ... Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a ... Trinucleotide expansion mutations in the cartilage oligomeric matrix protein (COMP) gene. Human Molecular Genetics 1999, 8(1), ... Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Nature ...

https://www.ncl.ac.uk/medical-sciences/people/profile/michaelbriggs.html

Cartilage Oligomeric Matrix Protein 100% * Angiopoietin-1 91% * Blood Vessels 21% * human ANGPT1 protein 18% ... Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, ...

https://pure.qub.ac.uk/en/persons/tim-curtis

Cartilage oligomeric matrix protein (COMP) is an impo ... Cartilage oligomeric matrix protein (COMP) is an important non- ... Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.. Authors * ... Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.. Source. Takada Lab ... collagenous cartilage protein that is essential for the structural integrity of the cartilage extracellular matrix. The ...

https://www.mysciencework.com/publication/show/enhanced-activity-transforming-growth-factor-1-tgf-1-bound-cartilage-oligomeric-matrix-protein-4ed06b10

Cartilage Oligomeric Matrix Protein Responses to a Mechanical Stimulus Associate with Ambulatory Loading in Individuals with ... The objective of the study was to test the hypothesis that serum levels of cartilage oligomeric matrix protein (COMP) would ... tibial and femoral cartilage thickness are associated with baseline ambulatory kinetics and cartilage oligomeric matrix protein ... characteristics that influence cartilage thickness are related to serum concentrations of cartilage oligomeric matrix protein ...

https://www.researchgate.net/profile/Thomas-Andriacchi

Cartilage oligomeric matrix protein. 2%. (14/643). L 2 Question Complexity E Question Importance ... codes for peripheral myelin protein 22 (PMP 22) expressed in Schwann cells (most common) ... OBQ10.129) The PMP22 (peripheral myelin protein 22) is found at the cytogenetic location found in Figure A. What pediatric ... Genetic mutations in axons or myelin protein leads to leg muscle atrophy, loss of sensation and proprioception in early ...

https://www.orthobullets.com/pediatrics/4086/charcot-marie-tooth-disease?expandLeftMenu=true

... cartilage oligomeric matrix protein (sCOMP), and systemic modification of the chondrocyte markers, suggesting a protective ... F. Berenbaum, "Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)," Osteoarthritis and Cartilage ... S. Bellometti, P. Richelmi, T. Tassoni, and F. Bertè, "Production of matrix metalloproteinases and their inhibitors in ... S. Benedetti, C. Canino, G. Tonti et al., "Biomarkers of oxidation, inflammation and cartilage degradation in osteoarthritis ...

https://www.hindawi.com/journals/bmri/2018/1042576/

... cartilage oligomeric matrix protein, and bone sialoprotein in each of the study participants. ... Tags: Ankylosing Spondylitis, Bone, Bone Health, Bone Morphogenetic Protein, Cartilage, Collagen, C-Reactive Protein, G-Protein ... show that levels of matrix metalloproteinase (MMP)3, bone-morphogenetic protein (BMP)2, procollagen type II N-propeptide (PIINP ... The researchers measured baseline levels of MMP3, BMP2, PIINP, VEGF, and OPG, as well as C-reactive protein (CRP), sclerostin, ...

https://www.news-medical.net/news/20120608/Biomarkers-predict-progressive-spinal-damage-in-ankylosing-spondylitis.aspx

Journal Article] 【関節炎マーカーの基礎と臨床】COMP(cartilage oligomeric matrix protein)2006. *. Author(s). 松本智子 ... Journal Article] 【関節炎マーカーの基礎と臨床】COMP (cartilage oligomeric matrix protein)2006. *. Author(s). 松本智子 ... IGF binding protein / Cartilage tissue / インターロイキン / osteoarthritis / interleukin-1β / 軟骨修復 / cartilage repair … More Except ... The interaction of IGF and IGF

https://nrid.nii.ac.jp/nrid/1000030239107/

Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein. Haudenschild, D. R., ... Engineering a thermostable protein with two dna-binding domains using the hyperthermophile protein sac7d. Yang, J. M. & Wang, A ... Liu, W. C., Lin, Y. S., Jeng, W. Y., Chen, J. H., Wang, A. H. J. & Shyur, L. F., Nov 2012, In: Protein Engineering, Design and ... Tsai, W. L., Forbes, J. G. & Wang, K., Oct 1 2012, In: Protein Expression and Purification. 85, 2, p. 187-199 13 p.. Research ...

https://tmu.pure.elsevier.com/en/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Fgood_health_and_well_being&format=&ordering=title&descending=false&page=304

A Mutation in Cartilage Oligomeric Matrix Protein (COMP) Causes Early-Onset Osteoarthritis in a Large Kindred Study. Mu, S. C. ... Amphetamine activate protein kinase C and calcium/calmodulin-dependent protein kinase via NMDA receptor in primary cultures of ...

https://tmu.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2016&publicationYear=2019&publicationYear=2020&format=&ordering=type&descending=true&nofollow=true&page=133

Cartilage oligomeric matrix protein. $5.00. USD Add to cart. * Cathepsin B. $5.00. USD Add to cart ... EF-hand domain-containing protein D2. $5.00. USD Add to cart. * EGF-containing fibulin-like extracellular matrix protein 1. $ ... Proline-rich acidic protein 1. $5.00. USD Add to cart. * Prolow-density lipoprotein receptor-related protein 1. $5.00. USD Add ... GTP-binding nuclear protein Ran. $5.00. USD Add to cart. * H-2 class I histocompatibility antigen, Q10 alpha chain. $5.00. USD ...

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COMPcc, which stands for "cartilage oligomeric matrix protein coil coiled," is a pentamer arranged as five helixes that can ... "But with protein-derived macromolecules, we found that directionality controls assembly. ... In our particular case, we can ... Montclare says the advantage of using biological protein-based systems is that one has control over their three-dimensional ... Scientists at Polytechnic Institute of New York Universitys Protein Engineering and Molecular Design Lab are finding ...

https://engineering.nyu.edu/news/nyu-poly-researchers-find-secrets-smart-polymers

Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 ... The urine uric acid/creatinine ratio was higher in patients with cartilage degradation compared to those without cartilage ... Cartilage. Humans. Hypertrophy. Inflammation. Knee Joint. Knee*. Osteoarthritis. Osteoarthritis, Knee*. Osteophyte. Radiography ... Osteoarthritis Cartilage. 2013; 21:1452-1464. Article. 5. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E. ...

https://koreamed.org/SearchBasic.php?RID=2471962

Guinea pig cartilage oligomeric matrix protein,COMP ELISA KIT. 721€. Guinea pig Catalase (CAT)ELISA Kit. 721€ ... GOAT Chitinase-3-like Protein 1(YKL-40/CHI3L1)ELISA Kit. 721€ ... Goat Heat Shock Protein 90kDa Alpha A1(HSP90aA1)ELISA Kit. 721€ ...

http://usachinabio.com/catalogue/178339-bioassay?page=10

The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are ... Click on the protein counts, or double click on taxonomic names to display all proteins containing TSP1 domain in the selected ... We have shown previously that thrombospondin 1 (TSP1), a platelet alpha-granule and extracellular matrix protein, activates ... Crystal structure of circumsporozoite protein aTSR domain, R32 native form. 3vdk. Crystal structure of circumsporozoite protein ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=TSP1&START=667&END=742&E_VALUE=7.61e-10&TYPE=SMART&BLAST=WASWGSWSKCSNNCGGGVQSRRRSCENGNSCPGCGVVRSRGWGAGSGETYSPGGVGGSEATLTPKEFKTCNPEACP

3. Potential relevance of altered cartilage oligomeric matrix protein in psoriasis. Renata Bozó (HCEMM-USZ Skin Research Group) ... The study of the membrane microdomain localization of the prion-family proteins, prion and Shadoo and their interaction with ...

https://www.hcemm.eu/output/dissertations/

Cartilage Oligomeric Matrix Protein Entry term(s). COMP (Cartilage Oligomeric Matrix Protein) Protein, Thrombospondin 5 Protein ... Protéine oligomérique de la matrice du cartilage Entry term(s):. COMP (Cartilage Oligomeric Matrix Protein). Protein, ... Cartilage Oligomeric Matrix Protein - Preferred Concept UI. M0580485. Scope note. Major component of chondrocyte EXTRACELLULAR ... Protein, Thrombospondin-5. TSP5 (Thrombospondin-5). Thrombospondin 5 Protein. Thrombospondin-5 Protein. ...

https://decs.bvsalud.org/en/ths/resource/?id=55336&filter=ths_exact_term&q=PROTE%C3%8DNA+DE+LA+MATRIZ+OLIGOM%C3%89RICA+DEL+CART%C3%8DLAGO

Cartilage Oligomeric Matrix Protein Cathepsin K Club Cell Protein Clusterin Connective Tissue Growth Factor CXCL12 Cystatin C ... Angiopoietin-Like Protein 4 molecule Acylation-Stimulating Protein Adipocyte Fatty Acid Binding Protein Adiponectin Adipophilin ... Placental Protein 13 Procalcitonin Prolactin-Inducible Protein Prostaglandin D Synthase RANKL Regenerating Protein 1 alpha ... Agouti-Related Protein Allograft Inflammatory Factor 1 Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiostatin ...

https://www.biovendor.com/antibodies?molecule=Angiopoietin-Like+Protein+4&type=Polyclonal+Antibody&species=Human&application=ELISA

... serum cartilage oligomeric matrix protein and urinary Type II collagen telopeptides) were associated with knee OA progression, ... Estradiol receptors have been identified in normal and osteoarthritic cartilage, indicating that cartilage is sensitive to E2 [ ... for Treatment of Focual Cartilage Lesions," Osteoarthritis and Cartilage, Vol. 17, No. 11, 2009, pp. 1434-1439. doi:10.1016/j. ... M. Sharif, L. Shepstone, C. J. Elson, P. A. Dieppe and J. R. Kirwan, "Increased Serum C Reactive Protein May Reflect Events ...

https://file.scirp.org/Html/3-2040055_31386.htm

cartilage oligomeric matrix protein. 0.010. ACSL4. acyl-CoA synthetase long-chain family member 4. 0.010. ... Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian ...

http://imp.princeton.edu/predictions/process_ortho/fly-context-global/8055/?gene=139479

... human cartilage glycoprotein-39 (YKL-40), and cartilage oligomeric matrix protein (COMP) -- markers of endothelial injury, ... or between EPC levels and high values of C-reactive protein (,15) (P = 0.7). Swollen joint counts did not correlate with EPC ... there are areas of synovial hypoxia contributing to synovial and cartilage damage [4, 5]. Hypoxia is highly suggested to ...

https://arthritis-research.biomedcentral.com/articles/10.1186/ar2934

cartilage oligomeric matrix protein. U: 2. D: 3. CRADD. CASP2 and RIPK1 domain containing adaptor with death domain. U: 1 ...

https://senequest.net/search?type=go_term&search=protease%20binding

... common to extracellular matrix proteins. ADAMTS proteins have recently gained attention with the discovery of their role in a ... proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type ... Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and ... and ADAMTS4 was recently shown to cleave cartilage oligomeric matrix protein (TSP5) [35]. The ADAMTS2, -3, and -14 proteins ...

https://bmcecolevol.biomedcentral.com/articles/10.1186/1471-2148-5-11

OBJECTIVE: To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3 years of follow-up. (ox.ac.uk)
The COMP gene provides the instructions for making the COMP protein. (medlineplus.gov)
Specifically, the COMP protein is located in the extracellular matrix surrounding the cells that make up ligaments and tendons, and near cartilage-forming cells (chondrocytes). (medlineplus.gov)
The normal function of the COMP protein is not fully known. (medlineplus.gov)
Research has also shown that the COMP protein binds strongly to calcium. (medlineplus.gov)
Mutations in the COMP gene that cause dominant multiple epiphyseal dysplasia change one protein building block (amino acid) or result in small additions or deletions of amino acids in the COMP protein. (medlineplus.gov)
All identified mutations have occurred in two regions of the COMP protein, which are referred to as the type III and C-terminal domains. (medlineplus.gov)
COMP mutations lead to the improper folding of the COMP protein in the endoplasmic reticulum, a structure in the cell involved in protein processing and transport. (medlineplus.gov)
The abnormal COMP protein is unable to leave the endoplasmic reticulum, which causes this cellular structure to enlarge. (medlineplus.gov)
Researchers believe that the lack of COMP protein in the spaces between the chondrocytes leads to the formation of abnormal cartilage. (medlineplus.gov)
This mutation results in the deletion of a single amino acid, called aspartic acid, in the COMP protein. (medlineplus.gov)
Most other COMP gene mutations involve the substitution of one amino acid for another amino acid in the COMP protein. (medlineplus.gov)
Mutations in the COMP gene that cause pseudoachondroplasia also result in the buildup of COMP protein in the endoplasmic reticulum and eventual chondrocyte death. (medlineplus.gov)
Here, changes in cartilage oligomeric matrix protein (COMP), interleukin-6 (IL-6), and creatine phosphokinase (CPK) were monitored before and after 1hr of exposure to static axial trunk loading and again after 1hr of prone rest. (cdc.gov)
For example, cartilage oligomeric matrix protein (COMP) and matrilin-3 are expressed to the greatest extent by resting and proliferative chondrocytes, whilst type X collagen is expressed exclusively by hypertrophic chondrocytes. (ncl.ac.uk)
Cartilage oligomeric matrix protein (COMP) is an important non-collagenous cartilage protein that is essential for the structural integrity of the cartilage extracellular matrix. (mysciencework.com)
The repeated modular structure of COMP allows it to 'bridge' and assemble multiple cartilage extracellular matrix components such as collagens, matrilins, and proteoglycans. (mysciencework.com)
Our results demonstrate that mature COMP protein binds to multiple TGF-β1 molecules and that the peak binding occurs at slightly acidic pH. (mysciencework.com)
This study tested for associations between ambulatory joint loading (total joint moment, TJM, and vertical ground reaction force, vGRF) and changes in serum levels of cartilage oligomeric matrix protein (COMP) in respo. (researchgate.net)
They also found changes in the levels of a substance called cartilage oligomeric matrix protein (COMP) which builds up in the knees of individuals with arthritis or other joint problems. (undergroundhealthreporter.com)
Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis. (fou-spenshult.se)
Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in osteoarthrosis of the knee and hip joints. (cdc.gov)
ORF of cartilage oligomeric matrix protein (COMP) in pENTER vector with CMV promoter and C-terminal FLAG and His tags. (criver.com)
Cartilage oligomeric matrix protein (COMP), hyaluronan, soluble CD14 levels, and aggrecanase-1 (ADAMTS-4) activity in synovial fluid and COMP and hyaluronan in plasma were measured. (keele.ac.uk)
Serum CTX-II (collagen type II C-telopeptide) and COMP (cartilage oligomeric matrix protein) were reduced by 32% and 40%, respectively, on day 13 in NEM-treated rats. (nutraceuticalbusinessreview.com)
Moreover, the anti-RA activity of the optimized DH-TENV gel was assessed based on the RA-specific marker anti-cyclic cirtullinated peptide antibody (anti-CCP), the cartilage destruction marker cartilage oligomeric matrix protein (COMP) and the inflammatory marker interleukin-6 (IL-6). (amedicinecherry.com)

OA was defined as an articular disease resulting from loss of cartilage integrity in association with modifications of the adjoining bone tissue, due to an imbalance between catabolic phenomena and chondrocytic repair phenomena [ 7 ]. (hindawi.com)
Recent evidence suggests that the E 2 reductions occurring at menopause may mediate the degenerative changes of articular cartilage at the knee in women [4]. (scirp.org)
Adult methods such as increasing periosteal width or articular cartilage growth via microfractures may also be effective. (heightquest.com)
Articular cartilage growth is another one of the claims made by gainheight.com one of the Yoko height increasing sites. (heightquest.com)
As I said in my article on growing with articular cartilage that it is possible for articular cartilage growth but as a result of my microfractures which release bone marrow stem cells which stimulate articular cartilage growth(the bone marrow needs to be coupled with blood flow). (heightquest.com)
Osteoarthritis is a common, age-related disorder of the synovial joints, which primarily involves articular cartilage, synovium, and subchondral bones. (biomedcentral.com)
Pathologically, OA is characterized by focal loss of articular cartilage in weight-bearing areas and new bone formation at joint margins. (biomedcentral.com)
In articular cartilages, the composition of the matrix determines a structure with elastic and structural properties that facilitate the movements. (uchile.cl)
Small proteoglycans, as the fibromodulin and decorin, are differentially distributed in the articular cartilage sub-regions, suggesting a relation among the expression of those molecules and the presence of different biomechanical properties of the tissue. (uchile.cl)
According to that, this work was focused on the biochemical analysis of the extracellular matrix articular cartilages from scapular-humerus, ulnar-humerus and radial-humerus articulations of chicken, aiming to analyze small proteoglycans and identify the type of glycosaminoglycans present in each cartilage. (uchile.cl)

In the bones of the spine, hips, and limbs, the process of osteogenesis starts with the formation of cartilage, which is then converted into bone. (medlineplus.gov)
The disease manifests first as a molecular derangement (abnormal joint tissue metabolism) followed by anatomic, and/or physiologic derangements (characterized by cartilage degradation, bone remodeling, osteophyte formation, joint inflammation and loss of normal joint function), that can culminate in illness. (hindawi.com)
The findings, presented at the European League Against Rheumatism Annual Congress of Rheumatology in Berlin, Germany, show that levels of matrix metalloproteinase (MMP)3, bone-morphogenetic protein (BMP)2, procollagen type II N-propeptide (PIINP), vascular endothelial growth factor (VEGF), and osteoprotegerin (OPG) are associated with AS structural damage. (news-medical.net)
For example COMPcc can bind to Vitamin D, a non-dissolving molecule that happens to have profound implications for regenerative tissue and serves as a signaling hormone for the promotion of tissue differentiation into cartilage and bone. (nyu.edu)
5. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. (koreamed.org)
Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. (bvsalud.org)
It binds MATRILIN PROTEINS and is associated with development of cartilage and bone. (bvsalud.org)
Histopathologically, NEM-treated rats had significantly less inflammation, cartilage damage, bone resorption and pannus formation in both their ankle and knee joints compared with vehicle control animals. (nutraceuticalbusinessreview.com)
In vitro exposure of osteoblasts to EFMF supports cell differentiation and induces gene- and protein-expression patterns characteristic for endochondral ossification during bone fracture healing in vivo. (springeropen.com)
Mesenchymal cells in the fracture area undergo hypertrophy, differentiate and simultaneously secrete extracellular matrix (osteoid) mainly consisting of collagen type I. Chondroclasts remove the cartilage matrix, and differentiating osteoblasts use the remnants of cartilage matrix as scaffolds for the deposition of bone matrix [ 9 ]. (springeropen.com)
The initial step in osteogenesis is the differentiation of MSCs to osteoprogenitor cells, which is driven by wingless-type mouse mammary tumor virus (MMTV) integration site family members (WNTs) and bone morphogenetic proteins (BMPs) [ 58 ]. (springeropen.com)

Osteoarthritis is low-grade inflammatory disease of synovial joints and is now defined as "a disorder involving movable joints characterized by cell stress and extracellular matrix degradation initiated by micro- and macro-injury that activates maladaptive repair responses including pro-inflammatory pathways of innate immunity. (hindawi.com)
Serum uric acid was significantly associated with synovial hypertrophy thickness (r=0.375, p=0.018) but not with cartilage thickness after adjusting for age and body mass index. (koreamed.org)
Figure 3 Multivariate analysis for correlation of uric acid with synovial hypertrophy and cartilage thickness in knee osteoarthritis. (koreamed.org)
To identify potential biomarkers in synovial fluid and plasma that can be used in the preoperative setting to help optimize patient selection for cell-based cartilage repair strategies. (keele.ac.uk)
The absence of ADAMTS-4 activity in the synovial fluid of joints with cartilage defects may be used in conjunction with known demographic risk factors in the development of an ACI treatment algorithm to help inform the preclinical decision. (keele.ac.uk)

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. (bris.ac.uk)
We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. (bris.ac.uk)
Dive into the research topics of 'Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. (bris.ac.uk)
Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis. (ox.ac.uk)
Thus, as serum E 2 concentrations decrease with menopause, a receptor-based mechanism may decrease the anabolic chondrocyte activity typical of premenopause, adversely affecting cartilage homeostasis [13]. (scirp.org)

6. Hao HQ, Zhang JF, He QQ, Wang Z. Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis. (koreamed.org)
Dose-response relationship of in vivo ambulatory load and mechanosensitive cartilage biomarkers-The role of age, tissue health and inflammation: A study protocol. (unibas.ch)

While the metalloprotease domain of ADAM proteins is followed by a disintegrin domain which binds integrins at a conserved X(D/E)ECD site [ 16 , 17 ], the corresponding amino acids in the disintegrin-like domain of ADAMTS proteins are not well conserved. (biomedcentral.com)

It was found in the thrombospondin protein where it is repeated 3 times. (embl.de)
The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. (biomedcentral.com)
ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins have homology with the metalloprotease region of the ADAM proteases, but also have at least one of the Thrombospondin type 1 Sequence Repeat (TSR) motifs that are common in extracellular matrix proteins. (biomedcentral.com)
On molecular level EFMF exposure led to a significant decreased thrombospondin 1 (THBS1) mRNA- (0.81) and protein- (0.54) expression, which in turn reduced the TGFß1-dependent mRNA- (0.68) and protein- (0.5) expression of transforming growth factor beta induced (ßIG-H3) significantly, an inhibitor of endochondral ossification. (springeropen.com)

Cartilage is made of water (70%) and a type II collagen framework with proteoglycans and glycosaminoglycans (consisting mainly of aggrecan and also chondroitin), produced by chondrocytes. (bmj.com)
1],[5] These factors can supposedly increase the rate of collagen deposition, angiogenesis, fibroblast proliferation, extra cellular matrix synthesis relevant to wound healing and soft tissue regeneration. (internationalshoulderjournal.org)
As investigated in in vitro cell culture studies at the level of human fibroblast cultures, exposure to electromagnetic fields has the potential to stimulate terminal differentiation of fibroblasts into functioning, highly collagen producing fibrocytes predominantly through modulation of Ca 2+ -influx and activation of protein kinase A [ 31 , 40 ]. (springeropen.com)
The physiological role of cartilage depends on the integrity of the matrix, made mainly by type 11 collagen fibers, proteoglycans and non collagen glycoproteins. (uchile.cl)

costochondritis is an inflammation of the cartilage connecting the rib cage to the sternum. (acorntravels.lk)

The biochemical analysis of extracellular matrix components has been carried out in several species, but it is scarce in avian. (uchile.cl)

The symptoms characteristic of this syndrome (short stature, brachydactyly, joint stiffness, and anomalies of the eye lenses), together with its expression patterns, suggest a role for the gene encoded by this protein in normal growth and in skin, eye, and heart development. (biomedcentral.com)

Connective tissues including ligaments, tendons, and cartilage. (acorntravels.lk)

Ultrasonographic abnormalities in knee OA includedsynovial hypertrophy, suprapatellar effusion, cartilage degradation, and osteophyte formation. (koreamed.org)
The urine uric acid/creatinine ratio was higher in patients with cartilage degradation compared to those without cartilage degradation (p=0.022). (koreamed.org)

And tissues in and around joints such as ligaments, tendons and cartilage. (acorntravels.lk)
Soft tissues in and around joints (cartilage, tendons, ligaments) can tear. (acorntravels.lk)
Abstract: The extracellular matrix is present in every tissue, but it is specially abundant in tendons and cartilages. (uchile.cl)

The expression of mutant forms of these cartilage structural proteins causes endoplasmic reticulum (ER) stress and induces an unfolded protein response (UPR). (ncl.ac.uk)

Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. (keele.ac.uk)

Immunoassays using anti-fibromodulin and anti-decorin, indicated that the components with 57 kDa and 70-90 kDa found in matrix of each joint analyzed are the small proteoglycans fibromodulin and decorin. (uchile.cl)

Of many muscles and ligaments attached to the cartilages of the voice box. (acorntravels.lk)

Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. (embl.de)

OBJECTIVE:To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes. (ox.ac.uk)

So you can envision loading them with drugs and delivering them in vivo, or using them as scaffolding for tissue engineering because they are protein-based and therefore suitable for the body without risk of eliciting an immune response. (nyu.edu)
ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue and blood disorders, cancer, osteoarthritis, Alzheimer's and the genetic syndromes Weill-Marchesani syndrome (ADAMTS10), thrombotic thrombocytopenic purpura (ADAMTS13), and Ehlers-Danlos syndrome type VIIC (ADAMTS2) in humans and belted white-spotting mutation in mice ( ADAMTS20 ). (biomedcentral.com)
Finally, this tissue un-dergoes remodeling due to extracellular matrix turnover mediated by matrixmetalloproteinases (MMPs). (2medicalcare.com)

At each stage of maturation in the growth plate, chondrocytes synthesise and secrete specific structural proteins that are incorporated into the extracellular matrix (ECM). (ncl.ac.uk)

Osteocytes are enriched in proteins that confer resistance to hypoxia, which is essential for their embedded location and restricted oxygen supply [ 11 ]. (springeropen.com)

Osteoarthritis is a chronic degenerative disorder characterised by cartilage loss. (bmj.com)

The cartilages obtained from proximal humerus, distal humerus in contact with the radius and distal humerus in contact with the ulna, presented higher content of uronic acid and sulfated glycosaminoglycans, when compared with cartilages obtained from proximal ulna and proximal radius. (uchile.cl)

Growth Factors for Rotator Cuff Repair Growth factors play an important role in cell chemotaxis, proliferation, matrix synthesis, and cell differentiation. (2medicalcare.com)

This abnormal cartilage probably breaks down easily, which results in early-onset osteoarthritis. (medlineplus.gov)
Charcot-Marie-Tooth Disease, also known as peroneal muscular atrophy, is a common autosomal dominant hereditary motor sensory neuropathy, caused by abnormal peripheral myelin protein, that presents with muscles weakness and sensory changes which can lead to cavovarus feet, scoliosis, and claw foot deformities. (orthobullets.com)

In the repair phase, several growth factors are upregu-lated that induce cellular proliferation and matrix deposition. (2medicalcare.com)
The following reorganization of the extracellular matrix is prerequisite for matrix mineralization and is characterised by increased Ca 2+ deposition (1.44). (springeropen.com)

Three steps are considered to be involved: 1) persistent and repeated bouts of injury to endothelial cells, 2) activation of innate and adaptive immunity and 3) fibroblast recruitment/activation, which results in accumulation of extracellular matrix and scarring [ 8 ]. (ersjournals.com)

It is therefore no surprise that New York University's College of Dentistry and NYU's Hospital for Joint Diseases are also involved with the NYU-Poly lab in developing new applications including cartilage repair. (nyu.edu)
The extent of cartilage loss can be estimated by measuring joint space width (JSW) on radiographs obtained in weight-bearing positions. (biomedcentral.com)

But with protein-derived macromolecules, we found that directionality controls assembly. (nyu.edu)

This protein is found in the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells. (medlineplus.gov)

Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. (qub.ac.uk)

Protein Expression and Purification. (elsevier.com)
mRNA- and protein-expressions were assessed during a time interval of 21 days and compared with expression data obtained from control osteoblasts. (springeropen.com)
The initial proliferative phase was characterized by a constitutively high mRNA expression of extracellular matrix proteins. (springeropen.com)

The complete taxonomic breakdown of all proteins with TSP1 domain is also avaliable . (embl.de)
Genetic: a genetic defect may promote breakdown of the protective architecture of cartilage. (acorntravels.lk)

The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. (embl.de)
Taxonomic distribution of proteins containing TSP1 domain. (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing TSP1 domain in the selected taxonomic class. (embl.de)
ADAMTS proteins are characterized by a pro-domain, a metalloprotease domain, the so-called disintegrin-like and spacer domains, and a tail of TSR repeats. (biomedcentral.com)
On the basis of this combined evidence, it is commonly believed that furin cleavage of the pro-domain might occur for all ADAMTS proteins. (biomedcentral.com)
The metalloprotease domain of ADAMTS proteins is shared with the related ADAM proteins, and the catalytic Zn2+-binding motif HEXGHXXXXXHD [ 15 ] is well conserved, shown at amino acid positions 761-772 [ Additional File 2 ]. (biomedcentral.com)

Concurrent EFMF exposure resulted in significanly increased cell proliferation (fold change: 1.25) and reduced mRNA-expressions of matrix components (0.5-0.75). (springeropen.com)

Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein. (mysciencework.com)
Anecdotal data indicate that PRP enhances the early wound-healing cascade by the interactions of activated platelet-released growth factors with the extra cellular matrix with potential potent anabolic affects. (internationalshoulderjournal.org)
Growth factors are expressed during the repair phase, because they promote cell prolifera-tion and matrix production. (2medicalcare.com)

Scientists at Polytechnic Institute of New York University's Protein Engineering and Molecular Design Lab are finding remarkable ways in which bioengineered paired macromolecules called block copolymers can be made to do these kinds of "smart" nano-acrobatics in both directions and then biodegrade when they've finished their work. (nyu.edu)

Spinal cord injury causing chronic paralysis affects the body's energy and protein requirements. (ijnpnd.com)

Anatomy10

Organisms1

Diseases9

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes6

Disciplines and Occupations1

Information Science2

Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. (1/201)

Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts. (2/201)

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. (3/201)

A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain. (4/201)

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. (5/201)

Molecular cloning and expression patterns of mouse cartilage oligomeric matrix protein gene. (6/201)

Pseudoachondroplastic dysplasia: an Iowa review from human to mouse. (7/201)

Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. (8/201)

Cartilage Oligomeric Matrix Protein

Matrilin Proteins

Extracellular Matrix Proteins

Achondroplasia

Glycoproteins

Osteochondrodysplasias

Cartilage

Collagen Type IX

Cartilage, Articular

Osteoarthritis

Chondrocytes

Collagen Type II

Synovial Fluid

Integrin-Binding Sialoprotein

Aggrecans

Biological Markers

Thrombospondins

Knee Joint

Osteoarthritis, Knee

Collagen Type XII

Extracellular Matrix

Chondrosarcoma

Collagen

Arthritis, Rheumatoid

Hyaluronic Acid

Chondrogenesis

Sialoglycoproteins

Collagen Type I

Enzyme-Linked Immunosorbent Assay

Tendons

Knee Injuries

Weight-Bearing

Proteoglycans

Synovial Membrane

Bone and Bones

Cells, Cultured

Immunohistochemistry

Mutation

Protein Binding

Amino Acid Sequence

Disease Progression

Microscopy, Electron

Molecular Sequence Data

Cattle

Cartilage Diseases

Protein Structure, Tertiary

Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. (1/201)

Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts. (2/201)

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. (3/201)

A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain. (4/201)

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. (5/201)

Molecular cloning and expression patterns of mouse cartilage oligomeric matrix protein gene. (6/201)

Pseudoachondroplastic dysplasia: an Iowa review from human to mouse. (7/201)

Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. (8/201)

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based...

Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Cartilage Oligomeric Matrix Protein - inflammation biomarker in knee osteoarthritis | Bosnian Journal of Basic Medical...

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis...

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based...

Value of Entheseal Ultrasonography and Serum Cartilage Oligomeric Matrix Protein in the Preclinical Diagnosis of Psoriatic...

Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis | Arthritis...

Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene....

Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With...

RCSB PDB - 1VDF: ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN

Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis -...

OP0010 Neutralisation of il-18 activity is a disease-modifying therapy in the murine collagen-induced arthritis model | Annals...

Cartilage oligomeric matr… - Göteborgs universitet

COMP Gene - GeneCards | COMP Protein | COMP Antibody

Lubricin binds cartilage … - Göteborgs universitet

JCI - Volume 108, Issue 12

Prognostic laboratory markers of joint damage in rheumatoid arthritis | Annals of the Rheumatic Diseases

ADAMTS7 - Wikipedia

Thrombospondins | Profiles RNS

Die Auswirkungen von Chondrodysplasie-assoziierten Mutationen auf die Struktur und Funktion des Cartilage Oligomeric Matrix...

Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice : Nephrology Dialysis Transplantation - oi

Pristance-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by MHC and...

Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis

Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis | Arthritis Research & Therapy |...

ModelDB: Cell splitting in neural networks extends strong scaling (Hines et al. 2008)

Comp Talks

$Gentaur Molecular :Kamiya \ COMP ELISA, Mouse and Rat \ KT-183$ Gentaur Molecular :Kamiya \ COMP ELISA, Mouse and Rat \ KT-183

$Gentaur Molecular :Kamiya \ COMP Clone 490D11 \ MC-1010$ Gentaur Molecular :Kamiya \ COMP Clone 490D11 \ MC-1010