Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.
PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Abnormal development of cartilage and bone.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Polymorphic cells that form cartilage.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.
Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.
Injuries to the knee or the knee joint.
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
Glycoproteins which have a very high polysaccharide content.
The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Pathological processes involving the chondral tissue (CARTILAGE).
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. (1/201)

Cartilage matrix protein (CMP; also known as matrilin-1), one of the major noncollagenous proteins in most cartilages, binds to aggrecan and type II collagen. We examined the effect of CMP on the adhesion of chondrocytes and fibroblasts using CMP-coated dishes. The CMP coating at 10-20 micrograms/ml enhanced the adhesion and spreading of rabbit growth plate, resting and articular chondrocytes, and fibroblasts and human epiphyseal chondrocytes and MRC5 fibroblasts. The effect of CMP on the spreading of chondrocytes was synergistically increased by native, but not heated, type II collagen (gelatin). The monoclonal antibody to integrin alpha1 or beta1 abolished CMP-induced cell adhesion and spreading, whereas the antibody to integrin alpha2, alpha3, alpha5, beta2, alpha5beta1, or alphaVbeta5 had little effect on cell adhesion or spreading. The antibody to integrin alpha1, but not to other subunits, coprecipitated 125I-CMP that was added to MRC5 cell lysates, indicating the association of CMP with the integrin alpha1 subunit. Unlabeled CMP competed for the binding to integrin alpha1 with 125I-CMP. These findings suggest that CMP is a potent adhesion factor for chondrocytes, particularly in the presence of type II collagen, and that integrin alpha1beta1 is involved in CMP-mediated cell adhesion and spreading. Since CMP is expressed almost exclusively in cartilage, this adhesion factor, unlike fibronectin or laminin, may play a special role in the development and remodeling of cartilage.  (+info)

Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts. (2/201)

OBJECTIVE: Cartilage oligomeric matrix protein (COMP) is a large disulfide-linked pentameric protein. Each of its five subunits is approximately 100,000 Da in molecular weight. COMP was originally identified and characterized in cartilage and it has been considered a marker of cartilage metabolism because it is currently thought not to be present in other joint tissues, except for tendon. To confirm the tissue specificity of COMP expression we examined cultured human dermal fibroblasts, human foreskin fibroblasts, and normal human synovial cells for the synthesis of COMP in culture. METHOD: Normal synovial cells and normal human dermal foreskin fibroblasts were isolated from the corresponding tissues by sequential enzymatic digestions and cultured in media containing 10% fetal bovine serum until confluent. During the final 24 h of culture, the cells were labeled with 35S-methionine and 35S-cysteine in serum- and cysteine/methionine-free medium. The newly synthesized COMP molecules were immunoprecipitated from the culture media with a COMP-specific polyclonal antiserum, or with monoclonal antibodies or affinity-purified COMP antibodies. The immunoprecipitated COMP was analyzed by electrophoresis in 5.5% polyacrylamide gels. For other experiments, synovial cells cultured from the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were similarly examined. RESULTS: A comparison of the amounts of COMP produced by each cell type (corrected for the DNA content) revealed that synovial cells produced > or = 9 times more COMP than chondrocytes or dermal fibroblasts. COMP could be easily detected by immunoprecipitation in all cell types. Electrophoretic analysis revealed a distinct band with an apparent MW of 115-120 kDa in samples from each of the three cell types, regardless of the antibody used. COMP expression in cultures of synoviocytes derived from OA and RA patients showed that OA and RA synovial cells produced similar amounts of monomeric COMP of identical size to those COMP monomers produced by normal synovial cells. The addition of TGF-beta to these cultures resulted in an increase in COMP production in normal, OA and RA synovial cells (45, 116 and 115% respectively). CONCLUSION: These studies demonstrate that substantial amounts of COMP are produced by several mesenchymal cells including synoviocytes and dermal fibroblasts. These findings raise important concerns regarding the utility of measurements of COMP levels in serum or in synovial fluid as markers of articular cartilage degradation because of the likelihood that a substantial proportion of COMP or COMP fragments present in serum or synovial fluid may be produced by cells other than articular chondrocytes.  (+info)

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. (3/201)

OBJECTIVE: To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip and knee osteoarthritis (OA), and to examine the potential utility of COMP as a diagnostic biomarker for knee OA. METHODS: Serum samples and knee and hip radiographs were obtained at a baseline evaluation as part of the Johnston County Osteoarthritis Project, a population-based study of OA in rural North Carolina. A total of 291 Caucasian participants were randomly selected for COMP analysis, 143 patients with radiographic knee OA (Kellgren/Lawrence [K/L] grade > or = 2) and 148 controls with neither hip nor knee OA (K/L grade 0), evenly distributed by age and gender. COMP was quantified by competitive enzyme-linked immunosorbent assay with monoclonal antibody 17-C10. The natural log-transformed COMP data were analyzed using general linear models. RESULTS: Serum COMP levels were significantly elevated (P = 0.0001) in the age > or = 65 group (mean +/- SD 1,302.1 +/- 496.7 ng/ml) versus the age 45-54 and age 55-64 groups (1,058.1 +/- 432.4 and 1,038.6 +/- 313.3, respectively). Serum COMP levels of the OA group were significantly higher than those of the control group (1,208.57 +/- 487.47 ng/ml versus 1,061.83 +/- 370.58 ng/ml; P = 0.0093). Serum COMP levels also increased significantly with knee OA K/L grade (P = 0.0047), knee OA laterality (P = 0.0043), and number of knee and hip joints involved (P = 0.0001). There was no significant difference in serum COMP levels by gender or obesity. CONCLUSION: We demonstrate that in a population-based sample, serum COMP levels can distinguish an OA-affected subgroup from an unaffected subgroup and can reflect disease severity and multiple joint involvement in OA.  (+info)

A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain. (4/201)

Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin family of extracellular matrix glycoproteins. All members of the family contain a highly conserved region of thrombospondin type 3 sequence repeats that bind calcium. A mutation in COMP previously identified in a patient with pseudoachondroplasia resulted in abnormal sequestration of COMP in distinctive rER vesicles. The mutation, Asp-446 --> Asn, is located in the type 3 repeats of the molecule. This region was expressed in a mammalian culture with and without the mutation to study the structural or functional properties associated with the mutation. The biophysical parameters of the mutant peptide were compared with those of the wild type and revealed the following difference: secondary structural analysis by circular dichroism showed more alpha-helix content in the wild-type peptides. The calcium binding properties of the two peptides were significantly different; there were 17 calcium ions bound/wild-type COMP3 peptide compared with 8/mutant peptide. In addition, wild-type COMP3 had a higher affinity for calcium and bound calcium more cooperatively. Calcium bound by the wild-type peptide was reflected in a structural change as indicted by velocity sedimentation. Thus, the effect of the COMP mutation appears to profoundly alter the calcium binding properties and may account for the difference observed in the structure of the type 3 domain. Furthermore, the highly cooperative binding of calcium to COMP3 suggests that these type 3 sequence repeats form a single protein domain, the thrombospondin type 3 domain.  (+info)

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. (5/201)

Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue-specific antigen. One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin-1.  (+info)

Molecular cloning and expression patterns of mouse cartilage oligomeric matrix protein gene. (6/201)

OBJECTIVE: To develop transgenic mice harboring mutations in the COMP gene as animal models for pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), autosomal dominant disorders characterized by early onset osteoarthritis and epiphyseal abnormalities. As a first step in generating a mouse model for COMP mutations, we have cloned the cDNA of mouse COMP and examined its tissue expression pattern. DESIGN: Total mRNA was isolated from the skeletal tissues of newborn C57BL/6j mice and used as a template for oligo(dT) first-strand cDNA synthesis. The cDNA was used for PCR amplification of COMP using three oligonucleotide primer pairs designed from the published rat COMP cDNA sequence. Nested PCR was used to complete the sequence between the amplified fragments. The entire cDNA was sequenced and the expression pattern of the corresponding transcripts examined by Northern hybridizations. RESULTS: A full-length COMP cDNA was isolated. Analysis showed that the entire translated region of the mouse COMP gene is 2268 bp and the derived amino acid sequence shows 90% homology to human COMP. Of eight adult mouse non-cartilage tissues tested, COMP expression was detected only in testis.  (+info)

Pseudoachondroplastic dysplasia: an Iowa review from human to mouse. (7/201)

Lamellar inclusions of the rough endoplasmic reticulum in growth plate chondrocytes, first identified (1972) in the Department of Orthopaedic Surgery, University of Iowa, has become the cytochemical hallmark for the pseudoachondroplastic dysplasia (PSACH) phenotype, linking an endoplasmic reticulum storage disorder with the osteochondrodysplasia. Since this original observation, great advances have been made, leading to the molecular understanding of this altered longitudinal bone growth anomaly. A PSACH canine model suggested that abatement of cumulative vertical growth of growth plate chondrocytes seen in PSACH results from (1) altered extracellular matrix constraints for horizontal growth and (2) uncoupling of endochondral and perichondral growth that causes metaphyseal flaring. PSACH, an autosomal dominant disease, is linked to mutation of the cartilage oligomeric matrix protein (COMP) gene. Amino acid substitutions, deletions, or additions is proposed to alter COMP structure that cause its retention in the rough endoplasmic reticulum of growth plate chondrocytes, leading to (1) compositional and structural change of the extracellular matrix, and (2) altered cellular proliferation and volume expansion. Normal growth and development occurs in COMP gene knockout mice that do not synthesis COMP, demonstrating that a mutant COMP, not absence of COMP, is required for the PSACH phenotype. The mechanism by which mutant COMP induces a PSACH phenotype remains to be elucidated. At the University of Iowa a cell culture system has been developed whereby mutant COMP transgenes are introduced into chondrocytes and the expressed product COMP is retained in the endoplasmic reticulum. This readily manipulated system makes it possible to decipher systematically the system's cellular secretory processing pathway, in order to clarify the mechanism(s) by which the mutant COMP is retained within the endoplasmic reticulum. Concurrent with this is the development of transgenic mice expressing the mutant COMP used in the cell culture system. This will make it possible to establish that expression of a human PSACH-linked mutant COMP will produce a PSACH phenotype. A PSACH animal model will provide a means to characterize the mechanism of altered longitudinal bone growth and to test gene therapy approaches for correcting the anomaly.  (+info)

Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. (8/201)

Mutations in residues in the type 3 calcium-binding repeats and COOH-terminal globular region of cartilage oligomeric matrix protein (COMP) lead to two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia. It has been hypothesized that these mutations cause COMP to misfold and to be retained in the endoplasmic reticulum. However, this hypothesis is not supported by previous reports that COMP, when purified in the presence of EDTA, shows no obvious difference in electron microscopic appearance in the presence or absence of calcium ions. Since this discrepancy may be due to the removal of calcium during purification, we have expressed wild-type COMP and the most common mutant form found in pseudoachondroplasia, MUT3, using a mammalian expression system and have purified both proteins in the presence of calcium. Both proteins are expressed as pentamers. Direct calcium binding experiments demonstrate that wild-type COMP, when purified in the presence of calcium, is a calcium-binding protein. Rotary shadowing electron microscopy and limited trypsin digestion at various calcium concentrations show that there are conformational changes associated with calcium binding to COMP. Whereas COMP exists in a more compact conformation in the presence of calcium, it shows a more extended conformation when calcium is removed. MUT3, with a single aspartic acid deletion in the type 3 repeats, binds less calcium and presents an intermediate conformation between the calcium-replete and calcium-depleted forms of COMP. In conclusion, we show that a single mutation in the type 3 repeats of COMP causes the mutant protein to misfold. Our data demonstrate the importance of calcium binding to the structure of COMP and provide a plausible explanation for the observation that mutations in the type 3 repeats and COOH-terminal globular region lead to pseudoachondroplasia.  (+info)

CONTEXT AND OBJECTIVE: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women. MATERIALS AND METHODS: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up. RESULTS: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33-2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared. DISCUSSION AND CONCLUSION: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and
OBJECTIVE:,br /,To test the hypothesis that physiological cyclic loading during a 30-min walking exercise causes an increase in serum cartilage oligomeric matrix protein (COMP) concentration in a healthy population.,br /,METHODS:,br /,Blood samples (5 ml) were drawn from 10 physically active adults immediately before and after, and 0.5h, 1.5h, 3.5h and 5.5h after a 30-min walking exercise on a level outdoor walking track at self-selected normal speed. On a separate day, blood samples were drawn from the same 10 subjects during 6h while they were resting in a chair. Serum COMP concentrations were determined using a commercial enzyme-linked immunosorbent assay (COMP ELISA). An activity monitor was used to record basic time-distance measurements of gait. Serum COMP concentrations within the exercise protocol and within the resting protocol were compared using separate repeated measures analyses of variance (alpha=0.05).,br /,RESULTS:,br /,In the exercise protocol, a first increase (9.7%; P=0.003) ...
Chondrocytes and synovial cells synthesize Cartilage Oligomeric Matrix Protein (COMP) when activated by proinflammatory cytokines. The aim of this study was to analyze and compare ultrasound parameters of joint inflammation, effusion and synovitis with the levels of COMP in the serum of patients with primary osteoarthritis. Ultrasound was done and the concentration of COMP (ng/mL was examined in 88 patients. 75% of patients had effusion (size 10.13±4.35 mm), 62.5% had effusion in lateral recessus (LR), 28.4% (size 8.53±2.27 mm) in suprapatelar (SR), and 27.3% (size 11.38±4.44 mm) in medial (MR). 67% of patients had synovitis size 4.84±3.57 mm in SR, 3.15±1.86 mm in MR; and 6.09±2.80 mm in LR. 17.0% of patients had nodular type of synovitis, 30.7% had diffusive, and 19.3% nodular - diffusive. There was a significant link between the size of synovitis and effusion in SR (r=0.966, p=0.000), MR (r=0.812, p=0.009) and LR (r=0.886, p=0.003). The median of COMP concentration was 54 (44.5-58) ...
We demonstrate that in a population-based sample, serum COMP levels can distinguish an OA-affected subgroup from an unaffected subgroup and can reflect disease severity and multiple joint involvement in OA.
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Until now, nothing has been known about the role of COMP during human development. COMP has been shown to be located in porcine joints, where high levels were seen in the proliferating zones and low levels were seen in the hypertrophic zones [5], which differs from what we found for human embryonic development. During human bone development investigated here, the strongest staining for COMP was seen in areas where joint development had taken place. This differs from mouse development, in which COMP is seen mainly in the perichondrium, but is in line with the present results, which demonstrate COMP-positive hypertrophic cartilage zones also during human development [27]. We were able to show COMP-positive superficial cartilage zones, as already described for mice [24]. Additionally, we detected COMP in the middle zones and in deep cartilage zones near the tidemark. Furthermore, COMP was detected in the basement membrane zones of the AER, the earliest signs of limb bud formation, but not in the ...
Osteoarthritis Cartilage. 2011 Oct;19(10):1246-53. doi: 10.1016/j.joca.2011.07.011. Epub 2011 Jul 29. Research Support, Non-U.S. Govt
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Objectives: To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA). Participants: Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female). Setting: Southeast of England, UK. Design: Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet. Measurements: All participants completed an Arthritis Impact Measurement Scale (AIMS2) pre-, mid- and post- study period. A subset of participants attended a clinic at the start and end of the study for assessment of joint range of motion, ROM (DIET = 33, CON = 28), and to provide blood samples (DIET = 29, CON = 25) for biomarker analysis (including serum cartilage oligomeric matrix protein (sCOMP) (a marker of cartilage degradation) and a panel of other relevant biomarkers including pro- and anti-inflammatory ...
Results Clinical scores were significantly reduced after IL-18 blockade (rhIL-18BP 1 mg/kg, p , 0.001, n = 13; anti-IL18 IgG, 2 mg, p , 0.05, n = 9, Mann Whitney test, treated versus placebo groups). Histological examination showed cartilage protection (decrease erosion scores, p , 0.05) that was accompanied by significantly reduced levels of serum cartilage oligomeric matrix protein (an indicator of cartilage turnover) and VDIPEN expression (a neoepitope present after digestion by matrix metalloproteinases). X-ray analysis of joints provided evidence of reduced bone erosion. ...
Both GH and IGF-I stimulate bone growth, but the molecular mechanisms mediating their effects on the growth plate are not fully understood. We measured gene expression by microarray analysis in primary cultured human chondrocytes treated with either GH or IGF-I. One of the genes found to be up-regulated by both GH and IGF-I was that encoding cartilage oligomeric matrix protein (COMP). This protein is predominantly found in the extracellular matrix of cartilage. Mutations in the COMP gene have been associated with syndromes of short stature. To verify that COMP is regulated by GH in vivo, we measured COMP levels in serum in short children treated with GH. The study included 113 short prepubertal children (14 girls and 99 boys) with a mean (+/- sd) age of 8.84 +/- 2.76 yr, height sd score of -2.74 +/- 0.67, and IGF-I sd score of -1.21 +/- 1.07 at the start of GH administration. Serum levels of COMP were 1.58 +/- 0.28, 1.83 +/- 0.28 (P < 0.0001), 1.91 +/- 0.28 (P < 0.0001), 1.78 +/- 0.28 (P < ...
Complete information for COMP gene (Protein Coding), Cartilage Oligomeric Matrix Protein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint. Immunohistochemical analysis of human cartilage biopsies showed lubricin and COMP co-localise to the cartilage surface. COMP knockout mice, however, presented with a lubricin layer on the articular cartilage leading to the further investigation of additional lubricin binding mechanisms. Proximity ligation assays (PLA) on human cartilage biopsies was used to localise additional lubricin ...
Two distinct IL-18 neutralizing strategies, i.e. a rabbit polyclonal anti-mouse IL-18 IgG and a recombinant human IL-18 binding protein (rhIL-18BP), were used to treat collagen-induced-arthritic DBA/1 mice after clinical onset of disease. The therapeutic efficacy of neutralizing endogenous IL-18 was assessed using different pathological parameters of disease progression. The clinical severity in mice undergoing collagen-induced arthritis was significantly reduced after treatment with both IL-18 neutralizing agents compared to placebo treated mice. Attenuation of the disease was associated with reduced cartilage erosion evident on histology. The decreased cartilage degradation was further documented by a significant reduction in the levels of circulating cartilage oligomeric matrix protein (an indicator of cartilage turnover). Both strategies efficiently slowed disease progression, but only anti-IL-18 IgG treatment significantly decreased an established synovitis. Serum levels of IL-6 were ...
Objective: To investigate whether determination of a set of laboratory markers at baseline provides prognostic information on joint damage in hands and feet in rheumatoid arthritis.. Methods: 183 patients with early rheumatoid arthritis included in a prospective study were examined. Radiographic changes in hands and feet at 5 and 10 years after inclusion were evaluated (Larsen). The markers analysed were: erythrocyte sedimentation rate (ESR); HLA-DRB alleles typed by restriction fragment length polymorphism; and C reactive protein, cartilage oligomeric matrix protein (COMP), rheumatoid factor (RF) (IgG, IgA, and IgM subtypes), antibodies against cyclic citrullinated peptide (anti-CCP), and antibodies against interleukin 1α (anti-IL1α), analysed by immunoassays. Multiple linear regression with backward elimination was used to determine the prognostic value of the variables.. Results: 117/176 patients were positive for IgG RF, 138/176 for IgA RF, 139/176 for IgM RF, 140/176 for anti-CCP, and ...
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) is an enzyme that in humans is encoded by the ADAMTS7 gene on chromosome 15. It is ubiquitously expressed in many tissues and cell types. This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. ADAMTS7 has been associated with cancer and arthritis in multiple tissue types. The ADAMTS7 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. The ADAMTS7 gene resides on chromosome 15 at the band 15q24.2 and contains 25 exons. This 1686-amino acid protein belongs to the ADAMTS family and is one of 19 members known in humans. As an ADAMTS protein, ADAMTS7 contains a shared proteinase domain and an ancillary domain. The proteinase domain can be further divided into a signal peptide, a prodomain, a metalloproteinase domain, and a disintegrin-like domain. In particular, the metalloproteinase domain contains a cysteine-switch motif in its binding site ...
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
Background. Peritubular capillary injury induces chronic hypoxia in the renal tubulointerstitium, and renal peritubular capillary dysfunction is an early event that contributes to tubulointerstitial fibrosis. Cyclosporine A (CsA) is a potent immunosuppressant and improves survival of renal allografts. However, the limitation of CsA use is chronic nephrotoxicity. A soluble, stable and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1 has been developed. We investigated whether COMP-Ang1 ameliorates CsA-induced renal injury.. Methods. CsA-treated mice were injected with recombinant adenovirus expressing either COMP-Ang1 or LacZ. Histology, inflammatory, haemodynamic and fibrotic parameters, and signalling pathway were evaluated.. Results. Histologic examination showed that COMP-Ang1 significantly decreased CsA-induced tubular damage and tubulointerstitial fibrosis. CsA-induced increases in macrophage infiltration and expression of MCP-1 and ICAM-1 after CsA ...
article{a79f8280-0e9f-4f33-82c9-d5b574133dd0, abstract = {We present a novel animal model for rheumatoid arthritis induced with a well defined synthetic adjuvant oil, pristane. Two weeks after a single intradermal injection of 150 microliters of pristane, the rats developed severe and chronic arthritis. The inflammation was restricted to the joints and involved pannus formation, major histocompatibility complex (MHC) class II expression, and T lymphocyte infiltration. The initial development as well as the chronic stage of pristane-induced arthritis was ameliorated by treatment with antibodies to the alpha beta-T-cell receptor showing that the disease is T cell dependent. Increased levels of interleukin in serum was seen after pristane injection but not during the chronic stage of arthritis. Joint erosions were accompanied by elevated serum levels of cartilage oligomeric matrix protein. Comparison of MHC congenic LEW strains showed that the severity and chronicity of arthritis varied among the ...
article{8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe, abstract = {OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms. ,br, ,br, METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation. ,br, ,br, RESULTS The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p<0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory ...
Antibodies binding to cartilage proteins are present in the blood and synovial fluid of early rheumatoid arthritis patients. In order to develop animal models mimicking the human disease, we have characterized the arthritogenic capacity of monoclonal antibodies directed towards different joint proteins in the cartilage. Purified antibodies specific to unmodified or citrullinated collagen type II (CII), collagen type XI (CXI), and cartilage oligomeric matrix protein (COMP) were produced as culture supernatant, affinity purified, pooled as antibody cocktails (Cab3 and Cab4), and injected intravenously into mice to induce arthritis. An adjuvant (lipopolysaccharide or mannan) was subsequently injected intraperitoneally on either day 5 or day 60 to enhance arthritis. Antibody binding and complement activation on the cartilage surface were analyzed by immunohistochemical methods. Bone erosions and joint deformations were analyzed by histological assessments, enzyme-linked immunosorbent assays, and micro-CT.
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Complete information for MATN4 gene (Protein Coding), Matrilin 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Workers comp is not a perfect system, and sometimes things can wrong or fall through the cracks. If an employee filed a valid claim, workers comp sh...
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Alciphron (Second Century). From a Mercenary Girl--Petala to Simalion. Warner, et al., comp. 1917. The Library of the Worlds Best Literature
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yeah so i installed a hardrive and my comp says the device is werking properly and all that, but it doesnt appear as a drive next to my old hardrive...
2002). "Cartilage oligomeric matrix protein-deficient mice have normal skeletal development". Mol Cell Biol. 22 (12): 4366-71. ... 1995). "Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene ... "COMP cartilage oligomeric matrix protein [ Homo sapiens (human) ]". "MATN3 matrilin 3 [ Homo sapiens (human) ]". d Briggs, ... Paulsson M, Heinegård D (1981). "Purification and structural characterization of a cartilage matrix protein". Biochem J. 197 (2 ...
The cartilage oligomeric matrix protein is 757 aa (OMIM 2008). COMP protein is found in the extracellular matrix, a complex web ... Pseudoachondroplasia is caused by a heterozygous mutation in the gene encoding cartilage oligomeric matrix protein (COMP). ... "Serum or plasma cartilage oligomeric matrix protein concentration as a diagnostic marker in pseudoachondroplasia: differential ... We do not yet fully understand the normal function of COMP protein, though it is believed to play a part in cellular growth, ...
2006). "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein". J. Biol. Chem. 281 (23): 15800-8. doi: ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ... Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ...
This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. ADAMTS7 has been associated ... a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein". FASEB Journal. 20 (7): 988-990. ... This 1686-amino acid protein belongs to the ADAMTS family and is one of 19 members known in humans. As an ADAMTS protein, ... participate in the protein's tight interaction with the extracellular matrix. ADAMTS7 was identified in a yeast two-hybrid ...
2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1- ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the ... "Entrez Gene: MMP19 matrix metallopeptidase 19". Murphy G, Knäuper V, Cowell S, et al. (1999). "Evaluation of some newer matrix ...
2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1- ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... and contains more protein and water. In general, MMP-20 functions in enamel are to cleave enamel matrix proteins at specific ... "Entrez Gene: MMP20 matrix metallopeptidase 20 (enamelysin)". Moradian-Oldak J (2012). "Protein-mediated enamel mineralization ...
... interaction with glycosaminoglycans and cartilage oligomeric matrix protein". J. Biol. Chem. 279 (23): 24265-73. doi:10.1074/ ... Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. This gene encodes one of the three alpha ... Wu JJ, Woods PE, Eyre DR (Dec 1992). "Identification of cross-linking sites in bovine cartilage type IX collagen reveals an ... Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule". Matrix Biol. 17 (3): 237-41. doi: ...
... is inherited in an autosomal dominant manner and is caused solely by mutations in the cartilage oligomeric matrix protein COMP ... Osteochondrodysplasia is a general term for a disorder of the development (dysplasia) of bone ("osteo") and cartilage ("chondro ...
... interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. ... Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene. ZBTB7A has been ... ZBTB7A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) FactorBook ZBTB7A This article ... Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327-35. ...
... non-collagenous extracellular matrix components, including: 3% cartilage oligomeric matrix protein, 1-2% elastin, 1-5% ... Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as ... Collagenous Extracellular Matrix Proteins and Minor Collagens in Tendon". Journal of Orthopaedic Research. 38 (1): 23-35. doi: ... signaling between the cell and the matrix. G-proteins, which induce intracellular signaling cascades, may also be important, ...
Kim HJ, Lee YH, Kim CK (2009). "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in ... The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein ... 2008). "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis". J. Mol. Biol. ... Li S, Bai JH, Park YD, Zhou HM (2006). "Capture of monomeric refolding intermediate of human muscle creatine kinase". Protein ...
... cartilage oligomeric matrix protein, bone morphogenetic protein, and other anabolic gene candidates are among the candidate ... OA is mostly the result of natural aging of the joint due to biochemical changes in the cartilage extracellular matrix. ... Genes, which contribute to protect and restore the matrix of articular cartilage, are attracting the most attention. These ... 2005). "Transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage ...
... a type of school in the United Kingdom Cartilage oligomeric matrix protein, or COMP Comparettia, an orchid genus Comp cards, ...
... (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ... "Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... "Entrez Gene: COMP cartilage oligomeric matrix protein". Paulsson M, Heinegård D (Aug 1981). "Purification and structural ... Rosenberg K, Olsson H, Mörgelin M, Heinegård D (Aug 1998). "Cartilage oligomeric matrix protein shows high affinity zinc- ...
... and serum cartilage oligomeric matrix protein (COMP) levels as a prognostic marker for incidence of both knee and hip ... a) cartilage erosion (b)cartilage ulceration (c)cartilage repair (d)osteophyte (bone spur) formation. Histopathology of ... The capsule and fluid protect the cartilage, muscles, and connective tissues. With osteoarthritis, the cartilage becomes worn ... the collagen matrix becomes more disorganized and there is a decrease in proteoglycan content within cartilage. The breakdown ...
Cartilage oligomeric matrix protein. This protein-related article is a stub. You can help Wikipedia by expanding it.. *v ...
Cartilage oligomeric matrix protein. Retrieved from "https://en.wikipedia.org/w/index.php?title=Elastin&oldid=866153192" ... extracellular matrix structural constituent. • protein binding. Cellular component. • proteinaceous extracellular matrix. • ... extracellular matrix. • collagen-containing extracellular matrix. Biological process. • animal organ morphogenesis. • cell ... extracellular matrix disassembly. • extracellular matrix organization. • blood circulation. • respiratory gaseous exchange. ...
Cartilage oligomeric matrix protein. *v. *t. *e. Proteases: metalloendopeptidases (EC 3.4.24) ...
Cartilage oligomeric matrix protein. Retrieved from "https://en.wikipedia.org/w/index.php?title=Cytokeratin&oldid=795752665" ... The term "cytokeratin" began to be used in the late 1970s, when the protein subunits of keratin intermediate filaments inside ... Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue. They are an important ... Numerous accessory proteins are involved in the genesis and maintenance of such structure. ...
Cartilage oligomeric matrix protein. Retrieved from "https://en.wikipedia.org/w/index.php?title=Laminin,_alpha_4&oldid= ... extracellular matrix structural constituent. • protein binding. Cellular component. • proteinaceous extracellular matrix. • ... "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Archivum ... extracellular matrix. • collagen-containing extracellular matrix. Biological process. • regulation of cell adhesion. • cell ...
Cartilage oligomeric matrix protein. Retrieved from "https://en.wikipedia.org/w/index.php?title=Collagen,_type_XX,_alpha_1& ...
In fact, collagen is the most abundant protein in the human body[15][16] and accounts for 90% of bone matrix protein content.[ ... Chondrocytes are found in cartilage and produce the cartilaginous matrix. Osteoblasts are responsible for bone formation. ... Extracellular matrix. Illustration depicting extracellular matrix (basement membrane and interstitial matrix) in relation to ... The animal extracellular matrix includes the interstitial matrix and the basement membrane.[5] Interstitial matrix is present ...
Cartilage oligomeric matrix protein. This protein-related article is a stub. You can help Wikipedia by expanding it.. *v ... The roles of such proteins include protection and support, forming connective tissue, tendons, bone matrices, and muscle fiber ... Scleroproteins or fibrous proteins[1] constitute one of the three main types of proteins (alongside globular and membrane ... Scleroproteins are structural proteins or storage proteins that are typically inert and water-insoluble. A scleroprotein occurs ...
... also designated cartilage oligomeric protein or COMP). TSP-1 and -2 are homotrimers, consisting of three identical subunits, ... Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the ... "Matricellular proteins and biomaterials". Matrix Biology. 37: 183-191. doi:10.1016/j.matbio.2014.03.002. PMC 4167162. PMID ... As such, TSP-1 is designated a multifunctional protein. TSP-1 has multiple receptors, among which CD36, CD47 and integrins are ...
Cartilage oligomeric matrix protein. Gene map locus 19p13.1 NOTCH3: Notch homolog 3 (Drosophila): Gene map locus 19p13.1-p13.2 ... encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger ... encoding protein Zinc finger protein 180 ZNF208: encoding protein Zinc finger protein 208 ZNF224: encoding protein Zinc finger ... encoding protein Zinc finger protein 225 ZNF226: encoding protein Zinc finger protein 226 ZNF229: encoding protein Zinc finger ...
Other extracellular matrix components such as matrix metalloproteins and integrins are also frequently co-expressed with TN-C. ... These protein modules are lined up like beads on a string and give rise to long and extended molecules. At the N-terminus each ... Tenascin C is an oligomeric glycoprotein composed of individual polypeptides with molecular weights ranging from 180 to ~300kDa ... bone and cartilage. The human tenascin C gene, TN-C, is located on chromosome 9 with location of the cytogenic band at the 9q33 ...
Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of ... Concatamers are oligomeric products of ligating a single gene with itself. This will result in repeat segments of a gene, all ... ELP networks to promote cell growth may prove indispensable in the production of tissue scaffolds that promote cartilage ... In this linear state, the ELP-protein complex cannot easily be distinguished from the extraneous proteins in the solution. ...
DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... Axin is then titrated away from its oligomeric assemblies - the β-catenin destruction complex - by Dsh. Once bound to the ... They also produce extracellular matrix components, such as type I collagen and fibronectin. Aberrant activation of the Wnt ... "Researchers Offer First Direct Proof of How Arthritis Destroys Cartilage" at rochester.edu Human CTNNB1 genome location and ...
Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ... "Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... "Entrez Gene: COMP cartilage oligomeric matrix protein". Paulsson M, Heinegård D (Aug 1981). "Purification and structural ... Rosenberg K, Olsson H, Mörgelin M, Heinegård D (Aug 1998). "Cartilage oligomeric matrix protein shows high affinity zinc- ...
ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN. *DOI: 10.2210/pdb1VDF/pdb. *Classification: EXTRACELLULAR MATRIX ... Crystallization and Preliminary Crystallographic Study of the Pentamerizing Domain from Cartilage Oligomeric Matrix Protein: A ... constituting the oligomerization domain in the cartilage oligomeric matrix protein (COMP), was determined at 2.05 angstroms ... constituting the oligomerization domain in the cartilage oligomeric matrix protein (COMP), was determine ... ...
Osteoarthritis Cartilage. 2011 Oct;19(10):1246-53. doi: 10.1016/j.joca.2011.07.011. Epub 2011 Jul 29. Research Support, Non-U.S ... Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene. ... Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene ... Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene ...
... vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage ... Assembly domain of cartilage oligomeric matrix protein Assembly domain of cartilage oligomeric matrix protein Assembly domain ... Assembly domain of cartilage oligomeric matrix protein Assembly domain of cartilage oligomeric matrix protein Assembly domain ... Assembly domain of cartilage oligomeric matrix protein Assembly domain of cartilage oligomeric matrix protein Assembly domain ...
Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen ... Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen ... Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen ... Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Englund, E LU ; Bartoschek ...
Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: A one year prospective ... Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: A one year prospective ... Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: A one year prospective ...
We suggest that cartilage oligomeric matrix protein (COMP) is one of the biomolecules that promotes anchoring of lubricin in a ... Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... We suggest that our findings can be extrapolated to cartilage surfaces, where co-localization of COMP and lubricin has been ...
Hedbom E, Antonsson P, Hjerpe A. Cartilge matrix proteins. An Acidic oligomeric protein (COMP) detected only in cartilage. J ... Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage ... Cartilage oligomeric matrix protein (COMP): A biomarker of arthritis. Biomarker Insight. 2009;4:33-44. [PMC free article] [ ... The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Current Drug Targets. 2008;9(10):869-77. [PubMed] ...
Cartilage Oligomeric Matrix Protein. By Technical Data. Cartilage Oligomeric Matrix Protein - Antibodies. Cartilage Oligomeric ... Cartilage Oligomeric Matrix Protein - Antibodies. Cartilage Oligomeric Matrix Protein - from Mouse - Antibodies. Cartilage ... Cartilage Oligomeric Matrix Protein - for Immunohistochemistry - Antibodies. Cartilage Oligomeric Matrix Protein - Antigene ... Bone and cartilage metabolism. Summary. Cartilage oligomeric matrix protein (COMP), also designated thrombospondin 5 (TSP 5), ...
We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti- ... Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course ... Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course ... Cartilage Oligomeric Matrix Protein Associates Differentially with Erosions and Synovitis and Has a Different Temporal Course ...
Objective. To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in ... High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with ... High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with ... High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with ...
Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α7β ... Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α7β ... Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α7β ... Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With ...
... von Chondrodysplasie-assoziierten Mutationen auf die Struktur und Funktion des Cartilage Oligomeric Matrix Proteins. PhD thesis ... von Chondrodysplasie-assoziierten Mutationen auf die Struktur und Funktion des Cartilage Oligomeric Matrix Proteins ...
Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis ... Objective: To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically ...
Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis. Biomark Insights. 2009;4:33-44. PubMedPubMedCentral ... Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology ... Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and ... Meanwhile, cartilage oligomeric matrix protein (COMP) and neopterin (NPT) levels in all samples were measured simultaneously ...
Cartilage Oligomeric Matrix Protein CHO , Rec. Prot. \ RGB002 for more molecular products just contact us ... Cartilage Oligomeric Matrix Protein CHO , Rec. Prot.. Related products : Human, Cartilage Oligomeric Matrix Protein CHO , Rec. ... Cartilage Oligomeric Matrix Protein CHO , Rec. Prot. / Product Detail : RGB002 Human, Cartilage Oligomeric Matrix Protein CHO ... Cartilage oligomeric matrix protein (COMP), also designated thrombospondin 5 (TSP 5), is non-collagenous glycoprotein and is a ...
... degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from ... RESULTS IL-1alpha stimulation of cartilage resulted in a fragmentation of COMP, which was inhibited by MMP inhibitors CGS ... METHODS COMP fragments were generated in vitro by treating (a) bovine articular cartilage with interleukin-1alpha (IL-1alpha ... Isolated, recombinant MMPs rapidly degraded purified COMP, as well as COMP residing in cartilage. Several COMP fragments ...
"Cartilage Oligomeric Matrix Protein" by people in this website by year, and whether "Cartilage Oligomeric Matrix Protein" was a ... "Cartilage Oligomeric Matrix Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Cartilage Oligomeric Matrix Protein*Cartilage Oligomeric Matrix Protein. *Thrombospondin 5 Protein. *Protein, Thrombospondin 5 ... Below are the most recent publications written about "Cartilage Oligomeric Matrix Protein" by people in Profiles. ...
... bound to cartilage oligomeric matrix protein. Together they form a unique fingerprint. * Cartilage Oligomeric Matrix Protein ... bound to cartilage oligomeric matrix protein",. abstract = "Cartilage oligomeric matrix protein (COMP) is an important non- ... N2 - Cartilage oligomeric matrix protein (COMP) is an important non-collagenous cartilage protein that is essential for the ... AB - Cartilage oligomeric matrix protein (COMP) is an important non-collagenous cartilage protein that is essential for the ...
HEK Protein from Prospec cat# pro-132. ProteoGenix provides you the best Recombinant proteins. Shop now from our 200 000 + ... Buy online Recombinant Human Cartilage Oligomeric Matrix Protein, ... More info about Recombinant Human Cartilage Oligomeric Matrix Protein, HEK Protein. Catalog#: pro-132. ... Data sheet of Recombinant Human Cartilage Oligomeric Matrix Protein, HEK Protein. Brand. Prospec. ...
We speculate these increases were an increase in cartilage turnover and an interesting observation related to increases in ... The primary objective of this study was to measure serum cartilage oligomeric matrix protein (sCOMP) levels weekly in a group ... Serum Cartilage Oligomeric Matrix Protein Levels in Collegiate Soccer Athletes over the Duration of an Athletic Season: A Pilot ... OBJECTIVE: The primary objective of this study was to measure serum cartilage oligomeric matrix protein (sCOMP) levels weekly ...
... Monoclonal antibody. Background. COMP - Cartilage oligomeric matrix protein is ... HOME / CONTENTS / Antibodies / Research Antibodies / Bone-Related Research / Anti COMP (Cartilage Oligomeric Matrix Protein) ... Anti COMP (Cartilage Oligomeric Matrix Protein) monoclonal antibody [CAC-PRPG-CP-M01] ... Fragments of COMP have been detected in the diseased cartilage, synovial fluid, and serum of patients with knee injuries, post- ...
1 Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin-4 (TSP-4) and type I and III Collagens in tendon An ... Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin-4 (TSP-4) and type I and III Collagens in tendon An ... Hyaline: support and flexibility Articular cartilage Costal cartilage Laryngeal cartilage Tracheal cartilage Nasal cartilage ... Cartilage Oligomeric Matrix Protein (COMP), Thrombospondin-4 (TSP-4) and type I and III Collagens in tendon ...
Protein Coding), Cartilage Oligomeric Matrix Protein, including: function, proteins, disorders, pathways, orthologs, and ... Protein Symbol:. P49747-COMP_HUMAN. Recommended name:. Cartilage oligomeric matrix protein Protein Accession:. P49747. ... Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. ( ... COMP (Cartilage Oligomeric Matrix Protein) is a Protein Coding gene. Diseases associated with COMP include Pseudoachondroplasia ...
Serum cartilage oligomeric matrix protein (COMP) and serum Hyaluronic acid (HA) are the two diagnostic biomarkers which are ... Li H, Wang D, Wu ZQ, Zhong JM, Yuan YJ (2012) Serum levels of cartilage oligomeric matrix protein in the diagnosis of knee ... 2011) Cartilage oligomeric matrix protein - inflammation biomarker in knee osteoarthritis. Bosn J Basic Med Sci 11(1): 27-32. ... Aims & Objectives: The aim of the study is to assess role of serum Cartilage oligomeric matrix protein (COMP) and serum ...
... Login ... Correlacoes clinico-radiologicas da COMP(cartilage oligomeric matrix protein) em individuos com osteoartrite de joelhos. ... Clinical-radiological correlations of COMP( cartilage oligomeric matrix protein) in knee osteoadthritis. ... cartilage oligomeric matrix protein) com o quadro clinico e radiologico de pacientes com osteoartrite (OA) isolada de joelhos e ...
Cartilage Oligomeric Matrix Protein Abstract. Chondrocytes and synovial cells synthesize Cartilage Oligomeric Matrix Protein ( ... Cartilage Oligomeric Matrix Protein - inflammation biomarker in knee osteoarthritis * Sandra Živanović Health Center Kragujevac ... Živanović S, Petrović Rackov L, Živanović A, Jevtić M, Nikolić S, Kocić S. Cartilage Oligomeric Matrix Protein - inflammation ... Cartilage oligomeric matrix protein has a moderate significance in the assessment of disturbance of the metabolism of synovial ...
The crystal structure of the signature domain of cartilage oligomeric matrix protein. ... The crystal structure of the signature domain of cartilage oligomeric matrix protein.. Coordinates. PDB Format Method. X-RAY ... Tan, K. et al., The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen ... Cartilage oligomeric matrix protein: A. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ...
Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ... Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ... Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ... Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy ...
Enhanced concentration of COMP (cartilage oligomeric matrix protein) in osteochondral fractures from racing Thoroughbreds ... cartilage oligomeric matrix protein) in osteochondral fractures from racing Thoroughbreds. JOURNAL OF ORTHOPAEDIC RESEARCH, 23 ...
  • Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. (wikipedia.org)
  • The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. (wikipedia.org)
  • The same structure probably occurs in two other extracellular matrix proteins, thrombospondins 3 and 4. (rcsb.org)
  • This study aims to investigate the regulation of expression of Cartilage oligomeric matrix protein (COMP), which is predominately expressed by chondrocytes and functions to organize the extracellular matrix. (nih.gov)
  • The amounts of COMP and Col2a1 proteins recovered from cells and their associated extracellular matrix were detected by Western blot. (nih.gov)
  • Cartilage oligomeric matrix protein (COMP), also designated thrombospondin 5 (TSP 5), is non-collagenous glycoprotein and is a member of the thrombospondin family of extracellular proteins. (biovendor.com)
  • 500kDa) present in the extracellular matrix of articular, nasal and tracheal cartilage. (biovendor.com)
  • Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases. (semanticscholar.org)
  • Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. (rush.edu)
  • Cartilage oligomeric matrix protein (COMP) is an important non-collagenous cartilage protein that is essential for the structural integrity of the cartilage extracellular matrix. (elsevier.com)
  • The repeated modular structure of COMP allows it to "bridge" and assemble multiple cartilage extracellular matrix components such as collagens, matrilins, and proteoglycans. (elsevier.com)
  • Degeneration to the tendon extracellular matrix (ECM) often precedes rupture and a high cyclic load is most likely an important factor explaining its high incidence in racing horses. (vdocuments.mx)
  • The heterooligomers of COMP and TSP-4 and the immunolocalization of TSP-4 indicate a function as an adhesion and/or signal molecule between the cell membrane and the extracellular matrix. (vdocuments.mx)
  • Among its related pathways are Focal Adhesion and Degradation of the extracellular matrix . (genecards.org)
  • May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. (genecards.org)
  • Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. (genecards.org)
  • This protein is found in the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells. (medlineplus.gov)
  • Specifically, the COMP protein is located in the extracellular matrix surrounding the cells that make up ligaments and tendons, and near cartilage-forming cells (chondrocytes). (medlineplus.gov)
  • The interplay network in the degradation of extracellular matrix mediated by ADAMTS-12 in arthritis. (nih.gov)
  • Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). (hindawi.com)
  • In biology, the extracellular matrix (ECM) is the extracellular part of multicellular structure (e.g., organisms, tissues, and biofilms) that typically provides structural and biochemical support to the surrounding cells [ 1 ]. (hindawi.com)
  • Integrins are transmembrane receptors that mediate the attachment between a cell and its surroundings, such as other cells or the extracellular matrix (ECM). (hindawi.com)
  • This protein is predominantly found in the extracellular matrix of cartilage. (gu.se)
  • Thus, extracellular matrix (ECM) components play a very important role in maintaining cell survival and behavior, and alterations in the ECM composition can lead to different pathologies. (frontiersin.org)
  • The extracellular matrix (ECM) is a complex three-dimensional network of proteins and carbohydrates that serves as a support for cells and tissues ( 1 ). (frontiersin.org)
  • At each stage of maturation in the growth plate, chondrocytes synthesise and secrete specific structural proteins that are incorporated into the extracellular matrix (ECM). (ncl.ac.uk)
  • The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. (portlandpress.com)
  • COMP (Cartilage Oligomeric Matrix Protein), also known as Thrombospondin-5, is a multidomain calcium binding protein that associates with other extracellular matrix molecules. (rndsystems.com)
  • The following testing regime has been recommended by the European Skeletal Dysplasia Network:[citation needed] Level 1: COMP (exons 10-15) and MATN3 (exon 2) Level 2: COMP (exons 8 & 9 and 16-19) Level 3: COL9A1 (exon 8), COL9A2 and COL9A3 (exon 3) All those genes are involved in the production of the extracellular matrix (ECM). (wikipedia.org)
  • It should play a role in the structural integrity of cartilage by its interaction with other extracellular matrix proteins and can be part of the interaction of the chondrocytes with the matrix and it is also a potent suppressor of apoptosis in chondrocytes. (wikipedia.org)
  • MATN3 protein may play a role in the formation of the extracellular filamentous networks and in the development and homeostasis of cartilage and bone. (wikipedia.org)
  • The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. (genecards.org)
  • Among its related pathways are ECM proteoglycans and Articular Cartilage Extracellular Matrix Pathway . (genecards.org)
  • Major component of the extracellular matrix of cartilage. (genecards.org)
  • In bone engineering, the adhesion, proliferation and differentiation of mesenchymal stromal cells rely on signaling from chemico-physical structure of the substrate, therefore prompting the design of mimetic "extracellular matrix"-like scaffolds. (mdpi.com)
  • Using an "extracellular matrix" (ECM)-like resorbable scaffold that cells can attach to, proliferate into, and migrate across, the damaged tissue may be replaced by the construct, which in turn is slowly resorbed and substituted by new functional tissue [ 3 ]. (mdpi.com)
  • Matrilin 3 plays a key role in the cartilage extracellular matrix. (encyclopedia.com)
  • Cartilage oligomeric matrix protein (COMP) and matrilin-3 (MATN3) are thought to bridge extracellular matrix proteins. (medscape.com)
  • Collagens, components of the extracellular matrix important for tissue architecture and function, undergo a complex series of processing events before and after secretion. (sciencemag.org)
  • however, treatment of HDFs with KGHR-containing, TSP1-binding, triple-helical peptides disrupted the collagen-TSP1 association, perturbed the collagen extracellular matrix, and increased myofibroblastic differentiation in a manner that depended on TGF-β receptor 1. (sciencemag.org)
  • The thrombospondins (TSPs) are a family of five extracellular calcium-binding proteins that bind to cell surface receptors including integrins and proteoglycans. (bidmc.org)
  • Through the interaction with extracellular matrix proteins and proteases, TSP-1 and -2 have been shown to regulate matrix structure. (bidmc.org)
  • It also affects extracellular matrix structure through interactions with collagens, matrilines, and proteoglycans. (bidmc.org)
  • Llano E, Pendás AM, Aza-Blanc P, Kornberg TB, López-Otín, C. Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodelling during neural development. (cicancer.org)
  • The cells in tissue are in contact with secreted extracellular macromolecules referred to as the extracellular matrix . (humpath.com)
  • Bosman FT, Stamenkovic I. Functional structure and composition of the extracellular matrix. (humpath.com)
  • Schenk S, Quaranta V. Tales from the crypt[ic] sites of the extracellular matrix. (humpath.com)
  • Results have demonstrated an association of increasing serum COMP levels with progressive destruction of articular cartilage monitored radiographically. (biovendor.com)
  • Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid. (semanticscholar.org)
  • COMP - Cartilage oligomeric matrix protein is a prominent multidomain glycoprotein of cartilage, accounting for up to 1% of the wet weight of articular tissues and having an approximate Mr of 97 kDa. (cosmobio.com)
  • Although the function of COMP is not completely elucidated, it appears to mediate chondrocyte attachment via integrins and to stabilize the articular cartilage ECM via specific cation-dependent interactions with collagen types II and IX, aggrecan, fibronectin, and ECM protein 1. (cosmobio.com)
  • Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. (hindawi.com)
  • The ECM of articular cartilage is a unique environment. (hindawi.com)
  • Microgravity during long-term space flights induces degeneration of articular cartilage. (dshs-koeln.de)
  • Osteoarthrosis (OA) is a common cause of musculoskeletal disability characterized by late-onset degeneration of articular cartilage. (cdc.gov)
  • Osteoarthritis (OA), the most common form of joint disease and cause of musculoskeletal disability in elderly people, is a disease affecting articular cartilage, bone, and soft tissue leading to joint destruction and severe impairment of mobility ( Felson and Zhang, 1998 ). (frontiersin.org)
  • Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. (gu.se)
  • COMP knockout mice, however, presented with a lubricin layer on the articular cartilage leading to the further investigation of additional lubricin binding mechanisms. (gu.se)
  • Overall, COMP, fibronectin and collagen II bind lubricin, exposed on the articular cartilage surface suggesting they may be involved in maintaining essential boundary lubrication. (gu.se)
  • Laborator Synevo Informatii generale si recomandari pentru determinarea COMP CARTILAJ OLIGOMERIC MATRIX PROTEIN (COMP) reprezinta un marker serologic specific care evalueaza gradul de degradare a cartilajului articular si turn-over-ul acestuia. (lamedic.ro)
  • Osteoarthritis is a chronic, degenerative disorder of unknown cause characterised by gradual loss of articular cartilage. (bmj.com)
  • Cartilage Oligomeric Matrix Protein (COMP) is a non-collagen protein in the matrix of articular cartilage (1). (pacbio.com)
  • Altered enchondral ossification may be associated with changes in the articular cartilage. (medscape.com)
  • The resultant articular cartilage is deficient in underlying osseous support and fails to withstand normal cyclical loading. (medscape.com)
  • Relapsing polychondritis (RP) is an autoimmune disease that affects extra-articular cartilage. (biomedcentral.com)
  • Serum cartilage oligomeric matrix protein reflects osteoarthritis presence andseverity: the Johnston County Osteoarthritis Project. (biovendor.com)
  • Serum cartilage oligomeric matrix protein and clinicalsigns and symptoms of potential pre-radiographic hip and knee pathology.Osteoarthritis Cartilage. (biovendor.com)
  • To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in patients with early-stage rheumatoid arthritis (RA) in relation to other serologic variables and magnetic resonance imaging (MRI) features. (jrheum.org)
  • To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip and knee osteoarthritis (OA), and to examine the potential utility of COMP as a diagnostic biomarker for knee OA. (nih.gov)
  • Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. (springermedizin.de)
  • Serum Cartilage Oligomeric Matrix Protein Levels in Collegiate Soccer " by Jessica L. Mateer, Johanna M. Hoch et al. (uky.edu)
  • OBJECTIVE: The primary objective of this study was to measure serum cartilage oligomeric matrix protein (sCOMP) levels weekly in a group of collegiate soccer athletes over the duration of a spring soccer season and 2 weeks following the conclusion of the season while documenting minutes of exercise participation as a measure of exercise intensity. (uky.edu)
  • The aim of the study is to assess role of serum Cartilage oligomeric matrix protein (COMP) and serum Hyaluronic acid (HA) levels as diagnostic biomarker and burden of disease biomarker in primary knee osteoarthritis. (medcraveonline.com)
  • Serum cartilage oligomeric matrix protein (COMP) and serum Hyaluronic acid (HA) are the two diagnostic biomarkers which are most often used [3,4]. (medcraveonline.com)
  • To test the hypothesis that physiological cyclic loading during a 30-min walking exercise causes an increase in serum cartilage oligomeric matrix protein (COMP) concentration in a healthy population. (uni-konstanz.de)
  • Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. (ox.ac.uk)
  • CONTEXT AND OBJECTIVE: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women. (ox.ac.uk)
  • These changes were accompanied by reduced osteoclast number and lowered levels of serum cartilage oligomeric matrix protein, a marker of cartilage breakdown. (aspetjournals.org)
  • Crnkic M, Mansson B, Larsson L, Geborek P, Heinegard D, Saxne T (2003) Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept. (springer.com)
  • It binds MATRILIN PROTEINS and is associated with development of cartilage and bone. (rush.edu)
  • Cartilage and bone metabolism in rheumatoid arthritis. (wikipedia.org)
  • Conclusion Our study provides additional evidence for the existence of different disease pathways in anti-CCP-positive and anti-CCP-negative subsets of RA, and evidence that anti-CCP antibodies may be implicated in the disease process by modifying cartilage metabolism. (jrheum.org)
  • The purpose of this study was to investigate the effect of different types of impact loading under normal and artificial gravity conditions on serum concentrations of cartilage oligomeric matrix protein (COMP), a biomarker of cartilage metabolism. (dshs-koeln.de)
  • In conclusion, both the amplitude and the number of the impacts contribute to inducing higher COMP responses and are therefore likely important factors affecting cartilage metabolism. (dshs-koeln.de)
  • In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). (plos.org)
  • An axial pore is formed by the coiled coil assembly and binds vitamin D3 which is involved in bone and cartilage metabolism. (rndsystems.com)
  • Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle. (kegg.jp)
  • In addition COMP may have a storage and delivery function for hydrophobic cellsignaling molecules such as vitamin D. The significance of COMP for normal development and function of cartilage has been underscored by the discovery that mutations of the COMP gene result in pseudoachondro-plasia and some forms of multiple epiphyseal dysplasia. (biovendor.com)
  • Mutations in the COMP gene that cause dominant multiple epiphyseal dysplasia change one protein building block (amino acid) or result in small additions or deletions of amino acids in the COMP protein. (medlineplus.gov)
  • All identified mutations have occurred in two regions of the COMP protein, which are referred to as the type III and C-terminal domains. (medlineplus.gov)
  • COMP mutations lead to the improper folding of the COMP protein in the endoplasmic reticulum, a structure in the cell involved in protein processing and transport. (medlineplus.gov)
  • Most other COMP gene mutations involve the substitution of one amino acid for another amino acid in the COMP protein. (medlineplus.gov)
  • Mutations in the COMP gene that cause pseudoachondroplasia also result in the buildup of COMP protein in the endoplasmic reticulum and eventual chondrocyte death. (medlineplus.gov)
  • Among them are pseudoachondroplasia and multiple epiphyseal dysplasia, both of which are caused by mutations in the cartilage oligomeric matrix protein (COMP) gene. (cdc.gov)
  • Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia. (ox.ac.uk)
  • Pseudoachondroplasia (PSACH) is an autosomal-dominant osteochondrodysplasia due to mutations in the gene encoding cartilage oligomeric matrix protein (COMP). (bvsalud.org)
  • The current study described the clinical and radiographic observations of six Chinese patients with PSACH, and identified two de novo novel missense mutations [p.Asp326Asn (c.976G>A) and c.1585A>G (p.Thr529Ala)] in cartilage oligomeric matrix protein (COMP) in the patients. (spandidos-publications.com)
  • EDM1 is caused by mutations in the COMP gene , which codes for the cartilage oligomeric matrix protein. (encyclopedia.com)
  • EDM2 and EDM3 result from mutations in two of the three genes that code for the protein chains of type IX collagen. (encyclopedia.com)
  • Defects in the matrilin 3 protein, caused by mutations in the MATN3 gene, lead to a diagnosis of EDM5. (encyclopedia.com)
  • The importance of COMP to cartilage synthesis and function is underscored by findings that COMP mutations lead to pseudoachondroplasia and a subgroup of multiple epiphyseal dysplasia designated EDM1. (bidmc.org)
  • Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene. (nih.gov)
  • COMP (Cartilage Oligomeric Matrix Protein) is a Protein Coding gene. (genecards.org)
  • The COMP gene provides the instructions for making the COMP protein. (medlineplus.gov)
  • Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in osteoarthrosis of the knee. (cdc.gov)
  • We measured gene expression by microarray analysis in primary cultured human chondrocytes treated with either GH or IGF-I. One of the genes found to be up-regulated by both GH and IGF-I was that encoding cartilage oligomeric matrix protein (COMP). (gu.se)
  • In micro-masses stimulated with SF, histological staining as well as gene expression analysis of typical chondrogenic marker genes showed that SF from ND and OA induced the chondrogenic marker genes aggrecan, types II and IX collagen, cartilage oligomeric matrix protein (COMP) and link protein, compared to controls not treated with SF. (nih.gov)
  • This gene encodes a member of von Willebrand factor A domain-containing protein family. (genecards.org)
  • MATN4 (Matrilin 4) is a Protein Coding gene. (genecards.org)
  • Cartilage oligomeric matrix protein (COMP) is the fifth member of the TSP gene family. (bidmc.org)
  • OBJECTIVE: To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M). (ox.ac.uk)
  • We can perform an assay validation of customer-selected biomarkers or adapt assays to special biological matrices like BALF, Synovial or Cerebrospinal fluids. (bioclinica.com)
  • Objetivo: Avaliar a correlacao entre os niveis sericos do marcador de degradacao de cartilagem COMP (cartilage oligomeric matrix protein) com o quadro clinico e radiologico de pacientes com osteoartrite (OA) isolada de joelhos e individuos assintomaticos em uma amostra da populacao brasileira. (unifesp.br)
  • Chondrocytes and synovial cells synthesize Cartilage Oligomeric Matrix Protein (COMP) when activated by proinflammatory cytokines. (bjbms.org)
  • Researchers believe that the lack of COMP protein in the spaces between the chondrocytes leads to the formation of abnormal cartilage. (medlineplus.gov)
  • For example, cartilage oligomeric matrix protein (COMP) and matrilin-3 are expressed to the greatest extent by resting and proliferative chondrocytes, whilst type X collagen is expressed exclusively by hypertrophic chondrocytes. (ncl.ac.uk)
  • Cartilage is made of water (70%) and a type II collagen framework with proteoglycans and glycosaminoglycans (consisting mainly of aggrecan and also chondroitin), produced by chondrocytes. (bmj.com)
  • In PSACH, a genetic mutation leads to abnormal retention of cartilage oligomeric matrix protein (COMP) within the endoplasmic reticulum (ER) of cartilage-producing cells (chondrocytes), which interferes with function and cell viability. (news-medical.net)
  • This is the first study linking ER stress to midline 1 protein (MID1), a microtubule stabilizer that increases mammalian target of rapamycin complex 1 (mTORC1) signaling in chondrocytes and other cell types. (news-medical.net)
  • In the current study, the researchers showed increased levels of MID1 protein in chondrocytes from the mutant dwarf mice as well as in cells from human PSACH patients. (news-medical.net)
  • Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis. (springermedizin.de)
  • Živanović S, Petrović Rackov L, Živanović A, Jevtić M, Nikolić S, Kocić S. Cartilage Oligomeric Matrix Protein - inflammation biomarker in knee osteoarthritis. (bjbms.org)
  • Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. (echosensclinicallibrary.com)
  • Other matrix molecules include type III collagen, proteoglycans, glycoproteins (COMP and TSP-4). (vdocuments.mx)
  • It is important for sulfation of proteoglycans and matrix organization. (wikipedia.org)
  • Joint cartilage is composed of a type II collagen-based fibrillar network complexed to proteoglycans. (pacbio.com)
  • A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying cells such as endothelial cells and epithelial cells . (humpath.com)
  • polysccharide chains of the class called glycosaminoglycans (GAG) which are usually found covalently linked to proteins in the form of proteoglycans. (humpath.com)
  • Multiple epiphyseal dysplasia (MED) is a hereditary disorder characterized by abnormal epiphyses (bone extremities) that lead to early-onset joint pain and recurrent inflammation of cartilage and bone. (encyclopedia.com)
  • Multiple epiphyseal dysplasia (MED) is a hereditary condition characterized by abnormal development of cartilage and bone. (encyclopedia.com)
  • The aim of this study is to assess the role of COMP (biochemical marker for cartilage degradation) and HA (biochemical marker for synovial inflammation) in early diagnosis of knee osteoarthritis (KOA). (medcraveonline.com)
  • The results of this work show that MID1, mTORC1 signaling, the microtubule network, protein synthesis, inflammation, and autophagy form a complex multifaceted response to protein accumulation in the ER when clearance efforts fail and MID1 may act as a pro-survival factor. (news-medical.net)
  • Chronic inflammation leads to destruction of joint cartilage and periarticular bone, as well as the development of generalized bone loss. (biomedcentral.com)
  • In conclusion, MHC genes, as well as non-MHC genes, are important for MIRP induction, and IL-10 plays a major suppressive role in cartilage inflammation of the respiratory tract. (biomedcentral.com)
  • The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. (jrheum.org)
  • and C reactive protein, cartilage oligomeric matrix protein (COMP), rheumatoid factor (RF) (IgG, IgA, and IgM subtypes), antibodies against cyclic citrullinated peptide (anti-CCP), and antibodies against interleukin 1α (anti-IL1α), analysed by immunoassays. (bmj.com)
  • Psoriatic arthritis damages cartilage, synovium and bone of the joints causing pain, impairment and disability making early recognition and intervention important. (pubmedcentralcanada.ca)
  • These studies describe that serum COMP level correlated with cartilage degradation and is a potential prognostic marker in inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). (biovendor.com)
  • OBJECTIVE To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. (semanticscholar.org)
  • Fragments of COMP have been detected in the diseased cartilage, synovial fluid, and serum of patients with knee injuries, post-traumatic and primary osteoarthritis and rheumatoid arthritis and have proposed to diagnostic/prognostic of degenerative cartilage diseases. (cosmobio.com)
  • Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. (gu.se)
  • Destruction of cartilage and bone is a poorly managed hallmark of human rheumatoid arthritis (RA). (aspetjournals.org)
  • Thus, in a model of experimental arthritis associated with significant osteolysis, p38α MAPK inhibition not only attenuates disease progression but also reverses cartilage and bone destruction in mice with advanced CIA disease. (aspetjournals.org)
  • The widespread argument generally follows the lines that running will slowly wear away the cartilage that cushions the bones in the joint and cause arthritis. (nytimes.com)
  • Cartilaginous ECM is remodeled continuously by a combination of production, degradation by matrix metalloproteinases (MMPs), and inhibition of MMPs activity by tissue inhibitors of MMPs [ 4 ]. (hindawi.com)
  • The crystal structure of the signature domain of cartilage oligomeric matrix protein. (expasy.org)
  • All-trans retinol, vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage oligomeric matrix protein. (cathdb.info)
  • Proximity ligation assays (PLA) on human cartilage biopsies was used to localise additional lubricin binding partners and demonstrated that lubricin bound COMP, but also fibronectin and collagen II on the cartilage surface. (gu.se)
  • Thrombospondin-1 (TSP1) plays an indirect role in collagen homeostasis through interactions with matrix metalloproteinases and transforming growth factor-β1 (TGF-β1). (sciencemag.org)
  • In that regard, a molecule known as thrombospondin-1 (TSP-1) is important because it is the first naturally occurring protein inhibitor of angiogenesis to be identified. (bidmc.org)
  • The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. (semanticscholar.org)
  • The abnormal COMP protein is unable to leave the endoplasmic reticulum, which causes this cellular structure to enlarge. (medlineplus.gov)
  • The expression of mutant forms of these cartilage structural proteins causes endoplasmic reticulum (ER) stress and induces an unfolded protein response (UPR). (ncl.ac.uk)
  • In general, the main components of the ECM are macromolecules and fibrous proteins as well as a wide variety of enzymes, including proteases, which are involved in processes such as the maturation, assembly, and renewal of ECM components. (frontiersin.org)
  • fibrous proteins of two functional types which have structural and adhesive types. (humpath.com)
  • Andersson ML, Thorstensson CA, Roos EM, Petersson IF, Heinegard D, Saxne T (2006) Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis. (springer.com)
  • Gentaur Molecular :Biovend \ Human, Cartilage Oligomeric Matrix Protein CHO , Rec. (antibody-antibodies.com)
  • their genotyping in conjunction with the assessment of classical protein molecular markers is recommended. (frontiersin.org)
  • In fact, members of both of these families of secreted multidomain proteins can interact with numerous other ECM components and thus shape or regulate the molecular environment. (frontiersin.org)
  • Investigador postdoctoral en el laboratorio del Dr. Carlos López-Otín en el departamento de Bioquímica y Biología molecular de la Universidad de Oviedo. (cicancer.org)
  • COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins. (semanticscholar.org)
  • In mice with early disease, SD-282 treatment significantly improved clinical severity scores, reduced bone and cartilage loss, and reduced mRNA levels of proinflammatory genes in paw tissue, including IL-1β, IL-6, and cyclooxygenase-2. (aspetjournals.org)
  • COL9A1, COL9A2, COL9A3 are genes coding for collagen type IX, that is a component of hyaline cartilage. (wikipedia.org)
  • Para ello, se abordará el análisis funcional mediante el desarrollo de mutantes murinos condicionales de genes implicados en esta ruta así como mediante el empleo de métodos de Screening genético directo en células ES. (cicancer.org)
  • De esta forma se dispondrá de nuevos modelos animales donde poder comprobar in vivo el papel que la alteración transitoria de esta actividad proteolítica tiene en la progresión tumoral así como la identificación funcional de nuevos genes implicados en estos procesos. (cicancer.org)
  • COMP is a marker of cartilage turnover. (wikipedia.org)
  • We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti-CCP-positive and anti-CCP-negative RA, and to study the temporal pattern of COMP through 4 years of treatment, including the relationship to imaging and clinical findings. (jrheum.org)
  • Increased serum levels of cartilage oligomeric matrix protein in patients with psoriasis vulgaris: a marker for unknown peripheral joint involvement? (semanticscholar.org)
  • They orchestrate cell-cell and cell-matrix adhesive interactions from embryonic development to mature tissue function. (hindawi.com)
  • In microfracture, subchondral mesenchymal cortico-spongious progenitor cells (CSP) enter the defect and form cartilage repair tissue. (nih.gov)
  • Llano E, Adam G, Pendas AM, Quesada V, Sánchez LM, Santamaría I, Noselli S, López-Otín C. Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. (cicancer.org)
  • The extra-cellualr matrix (ECM) forms a significant proportion of the volume of any tissue. (humpath.com)
  • The interstitial matrix is present in spaces between epithelial, endothelial, and smooth muscle cells and in connective tissue . (humpath.com)
  • Autoimmune diseases that affect cartilage tissue are widespread in the population. (biomedcentral.com)
  • p38 Mitogen-activated protein kinase (MAPK) has been shown to regulate key proinflammatory pathways in RA, including tumor necrosis factor α, interleukin (IL)-1β, and cyclooxygenase-2, as well as the process of osteoclast differentiation. (aspetjournals.org)
  • Ethnic and sex differences in serum levels of cartilageoligomeric matrix protein: the Johnston County Osteoarthritis Project. (biovendor.com)
  • COMP is not only cartilage-derived but was found widely in other tissues, including synovium and tendon. (biovendor.com)
  • Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage. (rush.edu)
  • Because OA affects mainly bone, cartilage, and the synovium, structural molecules derived from these tissues could be candidate biological markers for OA. (frontiersin.org)
  • B) COMP protein is detected earlier than Col2a1 during chondrogenesis. (nih.gov)
  • The major signaling pathways that regulate chondrogenesis have been identified as wnt signal, nitric oxide (NO) signal, protein kinase C (PKC), and retinoic acid (RA) signal. (hindawi.com)
  • In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis. (hindawi.com)
  • We suggest that cartilage oligomeric matrix protein (COMP) is one of the biomolecules that promotes anchoring of lubricin in a fashion that facilitates lubrication. (diva-portal.org)
  • We suggest that our findings can be extrapolated to cartilage surfaces, where co-localization of COMP and lubricin has been demonstrated. (diva-portal.org)
  • This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint. (gu.se)
  • Immunohistochemical analysis of human cartilage biopsies showed lubricin and COMP co-localise to the cartilage surface. (gu.se)
  • We suggest that cartilage oligomeric matrix protein (COMP) is one of the biomolecules that promotes anchoring of lubricin in a fashion that facilitates lubrication.Weakly hydrophobic poly(methyl methacrylate) (PMMA) surfaces were coated by COMP and lubricin, individually and in combinations. (gu.se)
  • Furthermore, macrophages and CD4 + T cells were the most prominent cell types in inflammatory infiltrates of the tracheal cartilage. (biomedcentral.com)
  • Folgueras A, Pendás AM, Sanchez LM, López-Otín C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. (cicancer.org)
  • Meanwhile, cartilage oligomeric matrix protein (COMP) and neopterin (NPT) levels in all samples were measured simultaneously with ELISA. (springermedizin.de)
  • Serum COMP concentrations of 4 patients and age-compatible control group of 20 unrelated healthy subjects were analyzed on the basis of an ELISA Kit for human cartilage oligomeric matrix protein . (bvsalud.org)
  • Product Detail : RGB002 Human, Cartilage Oligomeric Matrix Protein CHO , Rec. (antibody-antibodies.com)
  • We have also other products like : Human, Cartilage Oligomeric Matrix Protein CHO , Rec. (antibody-antibodies.com)
  • In previous studies, Dr. Posey and her colleagues have investigated chondrocyte pathology in the growth plates of dwarf mice that express MT-COMP, in cultured rat chondrosarcoma (RCS) cells that express human MT-COMP, as well as in cultured cartilage nodules from PSACH patients. (news-medical.net)
  • Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. (portlandpress.com)
  • Our results demonstrate that mature COMP protein binds to multiple TGF-β1 molecules and that the peak binding occurs at slightly acidic pH. (elsevier.com)
  • We are currently working to identify signaling molecules and other membrane proteins that collaborate with CD36 to inhibit endothelial cell function. (bidmc.org)
  • In contrast, the supplementation with SF from RA donors decreased the expression of aggrecan, type II collagen, COMP and link protein, compared to CSP treated with SF from ND or OA. (nih.gov)
  • Skeletal dysplasias, also known as osteochondrodysplasias, are a heterogeneous group of heritable disorders characterized by abnormalities of cartilage and bone growth, resulting in abnormal shape and size of the skeleton and disproportion of the long bones, spine, and head. (medscape.com)
  • In the ECM, especially the basement membrane, the multidomain proteins perlecan, agrin, and COLXVIII are the main proteins to which heparan sulfate attaches [ 7 ]. (hindawi.com)
  • Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). (genecards.org)
  • Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. (medlineplus.gov)
  • This observation was confirmed in vitro as COMP-expressing cells showed better survival as well as a higher rate of protein synthesis when treated with brefeldin A, compared with control cells. (lu.se)
  • This finding has significant implications for cellular functions including autophagy, protein synthesis, and potentially cellular viability. (news-medical.net)
  • Rough ER, the portion of ER displaying ribosomes, is the network of membranous tubules within cells associated with protein and lipid synthesis and export. (news-medical.net)