Pathological processes involving the chondral tissue (CARTILAGE).
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
Polymorphic cells that form cartilage.
Hyaline cartilages in the nose. There are five major nasal cartilages including two lateral, two alar, and one septal.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.
A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; COSTAL CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
Glycoproteins which have a very high polysaccharide content.
Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.
The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
The area between the EPIPHYSIS and the DIAPHYSIS within which bone growth occurs.
Breaks in CARTILAGE.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.
The flat, triangular bone situated at the anterior part of the KNEE.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
The interarticular fibrocartilages of the superior surface of the tibia.
The partition separating the two NASAL CAVITIES in the midplane. It is formed by the SEPTAL NASAL CARTILAGE, parts of skull bones (ETHMOID BONE; VOMER), and membranous parts.
The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.
One of a pair of small pyramidal cartilages that articulate with the lamina of the CRICOID CARTILAGE. The corresponding VOCAL LIGAMENT and several muscles are attached to it.
The small thick cartilage that forms the lower and posterior parts of the laryngeal wall.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The largest cartilage of the larynx consisting of two laminae fusing anteriorly at an acute angle in the midline of the neck. The point of fusion forms a subcutaneous projection known as the Adam's apple.
Inflammation of a bone and its overlaying CARTILAGE.
A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is synthesized as an inactive precursor that is activated by the proteolytic cleavage of its N-terminal propeptide.
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)
The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Injuries to the knee or the knee joint.
The posterior process on the ramus of the mandible composed of two parts: a superior part, the articular portion, and an inferior part, the condylar neck.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
The application of LUBRICANTS to diminish FRICTION between two surfaces.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC
Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)
A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.
Surgical techniques used to correct or augment healing of chondral defects in the joints (CARTILAGE, ARTICULAR). These include abrasion, drilling, and microfracture of the subchondral bone to enhance chondral resurfacing via autografts, allografts, or cell transplantation.
An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.
A technique for maintaining or growing TISSUE in vitro, usually by DIFFUSION, perifusion, or PERFUSION. The tissue is cultured directly after removal from the host without being dispersed for cell culture.
Methods of delivering drugs into a joint space.
A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.
A set of twelve curved bones which connect to the vertebral column posteriorly, and terminate anteriorly as costal cartilage. Together, they form a protective cage around the internal thoracic organs.
A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.

A comparative chemical and histochemical study of the chondrodystrophoid and nonchondrodystrophoid canine intervertebral disc. (1/338)

The chemical composition of the intervertebral disc of 9-month-old chondrodystrophoid and nonchondrodystrophoid dogs was studied for collagen, noncollagenous protein and glycosaminoglycan. Content of these substances differed significantly between breeds. The differences were most marked in the nucleus pulposus; the noncollagenous protein content of the nonchondrodystrophoid breed was higher than in that of the chondrodystrophoid dogs. The total nitrogen value of the nonchondrodystrophoid nuclei pulposi was less than that of the corresponding chondrodystrophoid discs mainly because of the high collagen content of the latter discs. Histochemically, it was found that the nuclei pulposi of the nonchondrodystrophoid breed contains larger amounts of glycosaminoglycan than in the discs of the chondrodystrophoid breeds.  (+info)

Gender differences in knee cartilage volume as measured by magnetic resonance imaging. (2/338)

OBJECTIVE: The aim of this study was to analyze sex differences in knee cartilage volume. METHODS: Articulate cartilage volumes were determined by processing images acquired in the sagittal plane using T1-weighted fat saturation magnetic resonance on an independent work station. The knees of 28 subjects (17 male, 11 female) who underwent MRI for clinical indications (pain <3 months) but who had a normal X-ray and structurally normal MRI were examined. RESULTS: Males had significantly larger cartilage volumes than females, with difference in cartilage volume remaining statistically significant after adjusting for age, height, weight and bone volume. The differences for males relative to females were: femoral cartilage volume [4.1 ml 95% CI (2.0, 6.1)]; and patella cartilage volume [1.4 ml (0.2, 2.7)]. Although not statistically significant, the tibial cartilage volume also showed these sex differences. Exploratory analysis indicated an increasing gender difference with increasing age for patellar cartilage volume. CONCLUSION: Men have significantly larger knee cartilage volume than women, independent of body and bone size. The mechanisms for this will need to be determined.  (+info)

Immunohistochemical observations on the initial disorders of the epiphyseal growth plate in rats induced by high dose of vitamin A. (3/338)

The initial disorders of the epiphyseal growth plate cartilage were immunohistochemically examined in the proximal tibia of rats administered a high dose of vitamin A. Male Wistar rats were given 100,000 IU/100 g body weight/day of vitamin A for administration periods of 1 to 5 days (Day 1 to 5) from 4 weeks after birth or were given deionized water and used as control. They were sacrificed after 5-bromo-2'-deoxyuridine (BrdU) injection on Day 1 to Day 5 to remove the tibiae. The tibiae were processed for immunohistochemical examinations using antibodies against type I, II, X collagens and BrdU. BrdU-incorporated chondrocytes and type X collagen-negative area were reduced since Day 2 and type X collagen-positive area was reduced since Day 4. The cartilage matrix partially lost type II collagen and deposited type I collagen in the epiphyseal growth plate near the periosteum on Day 5. These findings suggest that a high dose of vitamin A initially disturbed the differentiation from resting to proliferating chondrocytes, subsequently inhibited the differentiation from proliferating to hypertrophic chondrocytes, caused the chondrocytes to deviate from the process of normal differentiation, and finally resulted in the deformation of the epiphyseal growth plate.  (+info)

Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? (4/338)

This article reviews the experimental and clinical strategies currently in use or under development for the treatment of articular cartilage lesions. The vast majority of protocols under investigation pertain to the treatment of full-thickness defects (i.e., those which penetrate the subchondral bone and trabecular-bone spaces) rather than partial-thickness ones (i.e., those which are confined to the substance of articular cartilage tissue itself). This bias probably reflects the circumstance that partial-thickness defects do not heal spontaneously whereas full-thickness ones below a critical size do, albeit transiently. And it is, of course, a seemingly easier task to manipulate a process which is readily set in train than it is to overcome an induction-problem which Nature herself has not solved. Indeed, the reasons for this inert state of partial-thickness defects have only recently been elucidated, and these are briefly discussed. However, the main body of this review deals with the various transplantation concepts implemented for the repair of full-thickness defects. These fall into two broad categories: tissue-based (entailing the grafting of perichondrial, periosteal, cartilage or bone-cartilage material) and cell-based (utilizing chondroblasts, chondrocytes, periochondrial cells or mesenchymal stem cells). Cell-based systems are further subdivided according to whether cells are transplanted within a matrix (biodegradable, non-biodegradable or synthetic) or free in suspension. Thus far, the application of cell suspensions has always been combined with the grafting of a periosteal flap. The strengths and weaknesses of each concept are discussed.  (+info)

Biomechanics of integrative cartilage repair. (5/338)

Cartilage repair is required in a number of orthopaedic conditions and rheumatic diseases. From a macroscopic viewpoint, the complete repair of an articular cartilage defect requires integration of opposing cartilage surfaces or the integration of repair tissue with the surrounding host cartilage. However, integrative cartilage repair does not occur readily or predictably in vivo. Consideration of the 'integrative cartilage repair process', at least in the relatively early stages, as the formation of a adhesive suggests several biomechanical approaches for characterizing the properties of the repair tissue. Both strength of materials and fracture mechanics approaches for characterizing adhesives have recently been applied to the study of integrative cartilage repair. Experimental configurations, such as the single-lap adhesive test, have been adapted to determine the strength of the biological repair that occurs between sections of bovine cartilage during explant culture, as well as the strength of adhesive materials that are applied to opposing cartilage surfaces. A variety of fracture mechanics test procedures, such as the (modified) single edge notch, 'T' peel, dynamic shear, and trouser tear tests, have been used to assess Mode I, II, and III fracture toughness values of normal articular cartilage and, in some cases, cartilaginous tissue undergoing integrative repair. The relationships between adhesive biomechanical properties and underlying cellular and molecular processes during integrative cartilage repair remain to be elucidated. The determination of such relationships may allow the design of tissue engineering procedures to stimulate integrative cartilage repair.  (+info)

Concerning the ultrastructural origin of large-scale swelling in articular cartilage. (6/338)

The swelling behaviour of the general matrix of both normal and abnormally softened articular cartilage was investigated in the context of its relationship to the underlying subchondral bone, the articular surface, and with respect to the primary structural directions represented in its strongly anisotropic collagenous architecture. Swelling behaviours were compared by subjecting tissue specimens under different modes of constraint to a high swelling bathing solution of distilled water and comparing structural changes imaged at the macroscopic, microscopic and ultrastructural levels of resolution. Near zero swelling was observed in the isolated normal general matrix with minimal structural change. By contrast the similarly isolated softened general matrix exhibited large-scale swelling in both the transverse and radial directions. This difference in dimensional stability was attributed to fundamentally different levels of fibril interconnectivity between the 2 matrices. A model of structural transformation is proposed to accommodate fibrillar rearrangements associated with the large-scale swelling in the radial and transverse directions in the softened general matrix.  (+info)

Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases. (7/338)

We report three cases of para-articular chondroma and osteochondroma in the region of infrapatellar fat pad. All three lesions were resected and examined histologically. Two of them were primarily cartilaginous with a lobular pattern internally, and one uniformly osseous with peripheral cartilage. We conclude that these lesions are not the same. The former should be designated para-articular chondroma after Jaffe and the latter, osteochondroma.  (+info)

Premature termination codon in the aggrecan gene of nanomelia and its influence on mRNA transport and stability. (8/338)

AIM: To analyze the influence of the premature termination codon on mRNA transport and stability METHODS: Chondrocyte mRNA was isolated from homozygous and heterozygous nanomelic 17-days old embryos and examined by RT-PCR analysis. To analyze aggrecan mRNA stability, mRNA synthesis was inhibited with DRB [5,6 dichloro-1-(-D-ribofuranosyl benzimidazole)], a specific inhibitor of RNA polymerase II. Visualization of the aggrecan alleles was performed by in situ hybridization. RESULTS: The level of mutant aggrecan mRNA within the nucleus was equal to that of the control, but no mutant mRNA was observed in the cytoplasm. RT-PCR revealed that the mutant transcript was only detectable in the nucleus, compared with house-keeping glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene or collagen type II. A restriction site induced by premature termination codon TAA allowed the distinction of normal and mutant transcripts in chondrocytes derived from embryos heterozygous for the nanomelic mutation. After the treatment with DRB, identical decay rates were demonstrated for both transcripts within the heterozygous nucleus. In situ hybridization showed no abnormal mRNA accumulation. CONCLUSION: This is the first evidence suggesting that the transcript of the mRNA with the premature termination codon within an exon does exit the nucleus.  (+info)

TY - CHAP. T1 - Pure cartilage-based repair modalities of focal cartilage lesions. AU - Bárdos, T.. PY - 2013/6/1. Y1 - 2013/6/1. N2 - Focal cartilage lesions in diarthrodial joints have a limited capacity to heal, and repair techniques used at present are still unable to provide a universal solution. Osteochondral auto- and allografts are accepted and successful methods for the treatment of these lesions, but occasionally the osseal incorporation is delayed or insufficient and graft integration might be unsuccessful. Failure at this level generates a large osseos crater and the consequences can prove challenging. Until just a few years ago, it was a generally accepted dogma that when cartilage is detached from the subchondral bone it would fail to reintegrate to its bed and its surrounding cartilage. Recently, innovative approaches have been established to repair cartilage defects using pure cartilage-based implants, and so far they seem to have had considerable success. One of the available ...
This is a 12 year old Asian female with insidious onset of left hip pain 4 months in duration. At one point, her pain was so severe she could not bear weight and had to be picked up from school. She denies trauma to the hip. She could not participate in sports secondary to pain and also developed a limp with apparent leg length discrepancy secondary to pelvic obliquity and local muscle spasm. She complains of no other joint symptomatology. Her previous medical history is negative. ...
The joints consist of bones, cartilages (connective tissue) and synovial fluid. The role of cartilage is to reduce friction and optimize joint movement. Reduced synovial fluid production and cartilage degeneration leads to gradual degeneration of joints, resulting in increased friction, inflammation and thus reduced mobility and pain. This situation is called chondropathy or otherwise chondromalacia.. Chondropathy can affect any joint of the body, but the most common position is in the knee. It usually starts as a small destroy of a small area of cartilage either in the knee joint (knee chondropathy) and less often to the femur.. ...
Dr Domb offers cartilage defects treatment in Des Plaines, Chicagoland and Chicago, IL.Cartilage defects may result chronic degeneration due to overuse of the hip joint.
The treatment of chondral defects of the leg can depend upon the area and size of the problem. In general, those that are about the end of the thigh bone, the femur, are those who are easiest to treat and have the best outcomes. Those around the tibia and kneecap (patella) are harder to treat and the results are not as reliable. Intended for those patients who have got a surface defect of the cartilage, with a flap or crack in it, a cleaning out collaflex zamiennik or shaving of a defect, called a chondroplasty, can be performed. This may be useful to alleviate the catching and painful symptoms from a cartilage flap, but they do not cure the underlying chondral defect. In effect, it is resurfacing the defect and that is important the sufferer end up being careful about returning to those activities which caused the cartilage flap in the first place or it could happen all over once again ...
Cartilage replacement helps relieve pain, restore normal function, and can delay or prevent the onset of arthritis. Dr. Keller offers chondral defects treatment in Rochester, MI.
Fall River, MA (PRWEB) October 6, 2010 -- New, ground breaking research shows promising advancements in the battle against articular cartilage disease. A new
Chondropathy ChondropathyClassification & external resources ICD-10 M91.-M94. ICD-9 732-733 MeSH D002357 In medicine, Chondropathy refers to a disease of the
Ardmore Orthopaedic Clinic provides diagnosis and treatment options for cartilage injury. Visit this page to find out more or call us at 9631-7637 for enquiries.
Goodrich LR, Chen AC, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR. Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair? J Bone Joint Surg Am. 2016 Jan 06; 98(1):23-34 ...
academy according acquisition anatomical articular assessed assessment bandwidth bearing beginning biochemical bone cartilage channel classification clear clinical coefficient coefficients coil collagen concentration consecutive content correlation deep defect defects defined degeneration density derangement detection determine determined disease display divided drugs early eight empower enhanced equal evaluate evaluated evaluation examination examinations females femoral femur forty furthermore good grade graded gradient gray healthy heterogeneous horn hospital in vivo inconclusive increasing institute internal joint knee lateral layer lesion lesions loaded localized looking loss males manually mapping maps materials matrix medial medical meniscus might minutes modifying morphological ongoing orthopedic particular parts patients pinker pixel posterior progressive promising proton quantifying quantitative radiology regarding related relationship reported resolution respective retrospectively ...
OA Text is an independent open-access scientific publisher showcases innovative research and ideas aimed at improving health by linking research and practice to the benefit of society.
The Junya Toguchida laboratory reports a new iPS cell system to study chondrodysplasias. Many types of gene mutations are known to negatively affect a...
Full-thickness chondral defects and early osteoarthritis continue to present major challenges for the patient and the orthopaedic surgeon as a result of the ...
TY - JOUR. T1 - Matrix assisted autologous chondrocyte transplantation for cartilage treatment. T2 - A systematic review. AU - Kon, E.. AU - Filardo, G.. AU - Di Matteo, B.. AU - Perdisa, F.. AU - Marcacci, M.. PY - 2013/2/1. Y1 - 2013/2/1. N2 - Objectives: Matrix-assisted autologous chondrocyte transplantation (MACT) has been developed and applied in the clinical practice in the last decade to overcome most of the disadvantages of the first generation procedures. The purpose of this systematic review is to document and analyse the available literature on the results of MACT in the treatment of chondral and osteochondral lesions of the knee. Methods: All studies published in English addressing MACT procedures were identified, including those that fulfilled the following criteria: 1) level I-IV evidence, 2) measures of functional or clinical outcome, 3) outcome related to cartilage lesions of the knee cartilage. Results: The literature analysis showed a progressively increasing number of articles ...
TY - JOUR. T1 - Chondromalacia of the knee. T2 - Evaluation with a fat-suppression three-dimensional SPGR imaging after intravenous contrast injection. AU - Suh, Jin Suck. AU - Cho, Jae Hyun. AU - Shin, Kyoo Ho. AU - Kim, Sung Jae. PY - 1996. Y1 - 1996. N2 - Twenty-one MRI studies with a fat-suppression three-dimensional spoiled gradient-recalled echo in a steady state (3D SPGR) pulse sequence after intravenous contrast injection were evaluated to assess the accuracy in depicting chondromalacia of the knee. On the basis of MR images, chondromalacia and its grade were determined in each of five articular cartilage regions (total, 105 regions) and then the results were compared to arthroscopic findings. The sensitivity, specificity, and accuracy of MRI were 70%, 99%, and 93%, respectively. MR images depicted 7 of 11 lesions of arthroscopic grade 1 or 2 chondromalacia, and seven of nine lesions of arthroscopic grade 3 or 4 chondromalacia. The cartilage abnormalities in all cases appeared as focal ...
The University of Virginia, Department of Orthopaedic Surgery, is seeking adults with articular cartilage defects in the knee. The purpose of this study is to show if using an investigational tissue graft is better than the standard method of microfracture for the treatment of articular cartilage defects. This study will also document changes in knee pain and function after either surgery is performed.. The standard of care for treating articular cartilage defects in the knee is microfracture. This study is being done to observe if a graft is an efficient and more superior treatment option. For eligible participants, the defect will be treated with either microfracture or by using an investigational tissue graft.. This study involves 12 follow up visits over a 5 year period following surgery.. Study related clinic visits, research x-rays and MRI scans are provided free of charge. The study will also cover the costs of physical therapy that are not covered by your insurance up to $4,000 ...
BACKGROUND: Articular cartilage repair in the knee is aimed at young patients with area(s) of cartilage loss and no deformity of the knee. These patients arent indicated for a knee replacement. Articular cartilage repair leads to improvement of symptoms of pain, locking and function. Traditionally, articular cartilage repair has always involved exposing the entire knee joint with an arthrotomy. This, though effective, would lead to a large scar, longer hospital stay, longer rehabilitation and its associated complications. Also, the use of Bone Marrow Aspirate Cells (BMAC) for the purpose of cartilage repair has long been debated with both sides having valid arguments and good surgical results.. RATIONALE: Both procedures in this study are performed in one stage, arthroscopically and as day case procedures, which offers minimal scarring and quicker recovery. This automatically confers a significant advantage over the traditional surgical techniques.. To correct the articular cartilage defect, ...
Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.. ...
Complex cartilage lesions of the knee including large cartilage defects, kissing lesions, and osteoarthritis (OA) represent a common problem in orthopaedic surgery and a challenging task for the orthopaedic surgeon. As there is only limited data, we performed a prospective clinical study to investigate the benefit of autologous chondrocyte implantation (ACI) for this demanding patient population. Fifty-one patients displaying at least one of the criteria were included in the present retrospective study: (1.) defect size larger than 10 cm2; (2.) multiple lesions; (3.) kissing lesions, cartilage lesions Outerbridge grade III-IV, and/or (4.) mild/moderate osteoarthritis (OA). For outcome measurements, the International Cartilage Societys International Knee Documentation Committees (IKDC) questionnaire, as well as the Cincinnati, Tegner, Lysholm and Noyes scores were used. Radiographic evaluation for OA was done using the Kellgren score. Patients age was 36 years (13-61), defects size 7.25 (3-17.5) cm2,
A gold standard treatment for articular cartilage injuries is yet to be found, and a cost-effective and predictable large animal model is needed to bridge the gap between in vitro studies and clinical studies. Ideally, the animal model should allow for testing of clinically relevant treatments and the biological response should be reproducible and comparable to humans. This allows for a reliable translation of results to clinical studies.This study aimed at verifying the Göttingen minipig as a pre-clinical model for articular cartilage repair by testing existing clinical cartilage repair techniques and evaluating the use of two defects per knee. Sixteen fully mature Göttingen minipigs were used. The minipigs received bilateral trochlear osteochondral drill-hole defects or chondral defects (Ø 6 mm), either one defect per knee or two defects per knee. The defects were treated with one of the following: Matrix-induced autologous chondrocyte implantation (MACI), microfracture (MFx), autologous-dual
Cartilage degradation would result in osteoarthritis (OA). p16INK4awas found in some age-related diseases. In this study, we aimed to determine the role of p16INK4a during OA and to investigate the underlying mechanisms. Enzyme-linked immunosorbent assay (ELISA) was performed to test the activity of senescence-associated secretory phenotype (SASP). Real-time PCR (RT-PCR) and Western blot were used to determine the expressions of target genes. The increased expressions of p16INK4a and E2F2 were accompanied with cartilage degradation induced by IL-1β. Over-expression of p16INK4a enhanced the secretion of SASP markers (TGFβ, IL-6, IL-8, IL-1α, MMP3 and MMP13), reduced the expression of type II procollagen (COL2A1).Thus, the over-expression of p16INK4a lead to cartilage injury. Moreover, we found that the expression of E2F2 was enhanced in p16INK4a over-expression group, and that cartilage injury caused by p16INK4a was alleviated by depleting E2F2. p16INK4a was up-regulated during the cartilage injury in
Postarthroscopic glenohumeral chondrolysis is a condition in which the cartilage located within the shoulder joint begins to deteriorate. This typically occurs after an individual has had surgery on the affected shoulder. The condition generally affects the glenohumeral joint, which is the joint at the end of the shoulder comprised of the socket of the shoulder blade and the ball of the arm bone. The cartilage between these two portions of the arm and shoulder is the site affected by postarthroscopic glenohumeral chondrolysis. As the cartilage begins to deteriorate due to the condition, the individual starts to experience the complications associated with the disorder.. Individuals diagnosed with postarthroscopic glenohumeral chondrolysis experience stiffness and pain in the shoulder that has been affected by the condition and in some cases, they can lose the ability to move or use the affected shoulder. The cartilage in the shoulder joint is what allows the joint to move freely and smoothly. As ...
Chondromalacia (otherwise known as chondromalacia patellae, anterior knee pain syndrome, patellofemoral disorder or runners knee) is caused by improper tracking of the kneecap over the femur. As a result, the cartilage under the kneecap becomes roughened and pain results when the knee is bent or straightened while bearing weight.
Chondromalacia of the hip - I have chondromalacia patella with a hip labral tear on one leg. I have been in a flare for a month (both issues). Does this warrant a doctors visit? Yes. A rheumatologist or an Orthopedic physician should evaluate you to further determine your pain symptoms! To discuss with you further eval with MRIs and determine the best treatment, adjust your melds, adding Physical therapy, or perhaps an injection!!
Chondromalacia grade 4 treatment - What is the treatment for chondromalacia patellae? Medication P Therapy. And possible surgery if the other ones do not work.
Discussion. Chondral cartilage lesions do not heal spontaneously and may progress to severe osteoarthritis. For cartilage repair, a variety of surgical techniques have been established over the years. Further research led to the development of current new one-step cell-free scaffold-assisted cartilage repair approaches based on the experience with scaffold materials in previous two-step autologous chondrocyte implantation procedures. Commercially available scaffold-based products for one-step chondral cartilage repair have been recently tested in first case series and showed promising clinical outcome in the short-term follow-up; however, medium- and long-term comparative studies are necessary to evaluate the regenerative potential of this new one-step cartilage repair procedure and to demonstrate its superiority over or adequacy to traditional approaches.. Conclusion. This critical review summarises the development from two-step cell-based autologous chondrocyte implantation procedures to new ...
Repair of cartilage damage with autologous chondrocyte transplantation (ACT) has become popular in clinical use during the past few years. Although clinical results have mostly been successful, several unanswered questions remain regarding the biological mechanism of the repair process. The aim of this study was to develop a goat model for ACT. The repair was not successful due to the graft delamination, but we characterize the subchondral changes seen after the procedure. A chondral lesion was created in 14 goat knees, operated on 1 month later with ACT, and covered with periosteum or a bioabsorbable poly-L/D-lactide scaffold. After 3 months, only two of the five lesions repaired with ACT showed partly hyaline-like repair tissue, and all lesions (n = 4) with the scaffold failed. Even though the lesions did not extend through the calcified cartilage, the bone volume and collagen organization of bone structure were decreased when assessed by quantitative polarized light microscopy. There was a ...
Articular cartilage defects in the knee have a poor intrinsic healing capacity and may lead to functional disability and osteoarthritis. Cartilage cell therapy using autologous chondrocyte implantation (ACI) has been established as the first advanced treatment therapy medicinal product. Although this technique has achieved good mid-term results, it is a costly and extensive two-stage procedure which is limited by the number of chondrocytes obtained by biopsy and the dedifferentiation resulting from the expansion phase. Therefore, there is a need for improvement. A new cartilage repair technique should aim at decreasing surgical trauma, lowering complexity, improving logistics and cost-effectiveness while retaining or improving clinical outcome. Direct contact between mesenchymal stromal cells (MSCs) and dedifferentiated articular chondrocytes in vitro showed improvement of the chondrogenic phenotype of dedifferentiated articular chondrocytes. In addition, preserving the pericellular matrix of ...
Functional assessment of strains around a full-thickness and critical sized articular cartilage defect under compressive loading using MRI Journal Article ...
Study on mechanical behaviors of articular cartilage defect repaired area under cyclic compression loading, Xi-Ge Ma, Hai-Ying Liu, Cheng-Fei Du, Wei Wang, Chun-Qiu Zhang
Tracy McGrady underwent season-ending Microfracture Surgery on Feb. 24, a treatment for Cartilage Injuries that is becoming more and more common among athletes., New Treatment Techniques for Athletes Suffering from Cartilage Injuries
Canine Perichondritis - Causes and Treatment Perichondritis is the inflammation of the perichondrium, Arden Grange Dog Food Puppy located in the auricular
Any cartilage damage to the glenohumeral joint should be avoided, as these damages may result in osteoarthritis of the shoulder. To understand the pathomechanism leading to shoulder cartilage damage, we conducted a systematic review on the subject of articular cartilage lesions caused by traumas where non impression fracture of the subchondral bone is present. PubMed (MEDLINE), ScienceDirect (EMBASE, BIOBASE, BIOSIS Previews) and the COCHRANE database of systematic reviews were systematically scanned using a defined search strategy to identify relevant articles in this field of research. First selection was done based on abstracts according to specific criteria, where the methodological quality in selected full text articles was assessed by two reviewers. Agreement between raters was investigated using percentage agreement and Cohens Kappa statistic. The traumatic events were divided into two categories: 1) acute trauma which refers to any single impact situation which directly damages the articular
Another option is using the patients own cells, either cartilage cells or bone marrow stem cells, to attempt to re-grow new cartilage in the ulcer. This technique is called Autologous Chondrocyte Implantation (ACI). Typically this requires 2 separate operations, the first to harvest the cells, and the second to implant them. Culturing the cells usually takes between 3 to 6 weeks. The picture to the right shows ACI performed on a 3 cm square cartilage defect.. The implantation surgery is usually open traditional surgery, in which the cells are impregnated in a collagen scaffolding (that looks like a piece of wet tissue paper), and this is pasted into the cartilage defect. ...
Chondromalacia can be divided into 4 grades by MRI, typically using fat saturated proton density sequences. This grading system is the modified Outerbridge grading system, which was devised for arthroscopy initially for assessment of chondromalac...
Direct gene transfer strategies are of promising value to treat articular cartilage defects. Here, we tested the ability of a recombinant adeno-associated virus (rAAV) SOX9 vector to enhance the repair of cartilage lesions in vivo. The candidate cons
A knee cartilage injury can occur through trauma, overuse or age related degeneration, ranging from softening of the cartilage to a tear.
One important injury-activated pathway involves the release of pericellular fibroblast growth factor-2 (FGF2) from the articular cartilage. Using a novel model of murine cartilage injury, and joints from surgically destabilized mice we examined the extent to which FGF2 contributes to the cellular gene response to injury. Femoral epiphyses from 5 week old wild type mice were avulsed into serum-free medium. Explant lysates were western blotted for phospho-ERK, phospho-p38 and phospho-JNK or were fixed for immunohistochemistry for nuclear translocation of p65 (indicative of NFκB activation). RNA was extracted from injured explants, rested explants stimulated with recombinant FGF2 or FGF18, or whole joints of either wild type or Fgf2-/- mice. RT-PCR was performed for a number of inflammatory response genes previously identified from a microarray analysis. Murine cartilage avulsion injury resulted in the rapid activation of the three mitogen activated kinase pathways as well as NFκB. Almost all ...
Dr Russell LaFrance offers cartilage restoration surgery and treatment for cartilage injuries in Hamilton, Rome, Utica and Syracuse. Navigate to learn more.
Do your knees ache when you run? If youre running with a heel strike, this is why! Find out how heel striking when running leads to knee cartilage injury.
Summary: Osteoarthritis is a highly prevalent disease in the United States population, with approximately 75% of persons over age 65 having radiographic e...
Cartilage is generally tough but can be damaged or degenerated. If this occurs, the cartilage injury of the knee joint can be painful and will affect mobility.
In this study, Chinese researchers developed icariin-conditioned serum (ICS) and determined its ability - when combined with hyaluronic acid (HA) - to repair a critical-sized osteochondral defect in rabbit knees. Their results were published in the journal BMC Complementary and Alternative Medicine. Osteochondral defects are mostly caused by trauma or articular degeneration. Because of articular cartilages poor regenerative ability, osteochondral […]
M94.229 is a billable code used to specify a medical diagnosis of chondromalacia, unspecified elbow. Code valid for the year 2020
Vidant Health - Cartilage injury or inflammation can cause pain, swelling and limited movement and can also lead to overall joint damage.
Southern California Orthopedic Institutes fellowship-trained sports medicine surgeon Dr. Richard Ferkel discusses cartilage injuries of the ankle.
Perichondritis is an outer ear infection caused by wounds, boils, or burns and deadly microorganism. If left untreated, prechondritis can damage the
The term chondropenia indicates the early stage of degenerative cartilage disease, and it has been identified by carefully monitoring early-stage osteoarthritis (OA). Not only is it the loss of articular cartilage volume, but it is also a rearrangement of biomechanical, ultrastructural, biochemical and molecular properties typical of healthy cartilage tissue. Diagnosing OA at an early stage or an advanced stage is valuable in terms of clinical and therapeutic outcome. In fact degenerative phenomena are supported by a complex biochemical cascade which unbalances the extracellular matrix homeostasis, closely regulated by chondrocytes. In the first stage an intense inflammatory reaction is triggered: pro-catabolic cytokines such as IL-1β and TNF-α triggering matrix metalloproteases and aggrecanase (ADAMT-4 and 5), responsible for the early loss of ultrastructural components, such as type II collagen and aggrecan. In addition nitric oxide and reactive oxygen species modulate the physiopathology ...
Dr. Robert G. Marx has published over 275 scientific articles about knee and shoulder anatomy, injuries, and treatments. Here is one.
Cartilage defects are also called osteochondral defects. Bone Marrow Concentrate stem cell treatment is offered at Orthobiologics Clinic in Macclesfield, Manchester and Cheshire, UK.
Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on cartilage repair should be well understood for precise treatment. Our previous study showed tha
that in the past decade had suffered 2-3 times a year from bilateral knee pain which resolved spontaneously. Last year he had episodes of ... effusion in the sub-quadriceps recess, chondropathy of the femoropatellar joint and lesion of the medial meniscus. The diagnosis of the .... ...
Dr Matthew Wilkinson in Lenah Valley, South Hobart and Hobart TAS treats chondral lesions. Chondral injuries can result from various hip conditions such as labral tears, posterior dislocation, dysplasia, osteonecrosis and degenerative arthritis.
The existence of many new and encouraging biological approaches to cartilage repair justifies the future investment of time and money in this research area, particularly given the extremely high socio-economic importance of such therapeutic strategies in the prevention and treatment of these common …
{use-layout:ORTHOSEC} Workshop held in November 2000, manuscripts published as a supplement to the October 2001 issue of Clinical Orthopaedics and Related Research® (CORR) Issue Table of Contents The Classic - Age Changes in Articular Cartilage Symptomati
After 8 weeks:static bike without resistance After 6 months:Light jogging. After 12 months:Skiing. After 12-18 months: contact sports. ...
Cartilage damage can occur as a result of arthritis or an ankle sprain. Treatment by a foot specialist is the best way to get you back on your feet.
© Springer International Publishing Switzerland 2017. Mechanical stress is an obligatory aetiological factor in the development of OA so understanding how tissues of the joint respond to mechanical injury is likely to inform our understanding of pathogenesis. Much is known about how vascular tissues respond to damage, a process that involves activation of platelets on the exposed endothelium and recruitment of leukocytes to the site of injury. The articular cartilage is avascular yet responds rapidly and strongly to a range of mechanical stresses including cutting, avulsion, impact loading and shearing. It does so by activating a number of mechanosensitive pathways mediated by release of molecules trapped within the pericellular matrix as well as by triggering mechanoreceptors at the cell surface. In this way injury drives a number of intracellular signalling pathways, leading to a broad range of cellular responses. These pathways appear to be relevant to the in vivo response to mechanical disruption
... refers to a disease of the cartilage. It is frequently divided into 5 grades, with 0-2 defined as normal and 3-4 ... Cartilage tumors Costochondritis: Inflammation of cartilage in the ribs, causing chest pain. Osteoarthritis: The cartilage ... Though articular cartilage damage is not life-threatening, it does strongly affect the quality of life. Articular cartilage ... Relapsing polychondritis: a destruction, probably autoimmune, of cartilage, especially of the nose and ears, causing ...
"Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells ... Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, Ohgushi H (2007). "Repair of articular cartilage defects in the patello- ... "Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells, platelate ... have reported high field MRI evidence of increased cartilage and meniscus volume in individual human clinical subjects as well ...
... disease of the cartilage) A bone disease is also called an "osteopathy", but because the term osteopathy is often used to ... Osteochondropathy refers to a disease ("-pathy") of the bone and cartilage. However, it is more common to refer to these ...
June 2 - British surgeon William Hunter presents his paper "Of the structure and diseases of articulating cartilages". Copley ... Hunter, William (1743). "Of the Structure and Diseases of Articulating Cartilages". Philosophical Transactions of the Royal ...
In 1743 he published the paper On the structure and diseases of articulating cartilages - which is often cited - especially the ... Hunter, William (1743). "Of the structure and diseases of articulating cartilages". Philosophical Transactions of the Royal ... that an ulcerated Cartilage is universally allowed to be a very troublesome Disease; that it admits of a Cure with more ... Dunn PM (January 1999). "Dr William Hunter (1718-83) and the gravid uterus". Archives of Disease in Childhood. 80 (1): F76-7. ...
Osteochondrosis is a disease that affects the bone and cartilage in the joints of growing horses. The joints most commonly ... Osteochondrosis lesions include tiny fractures, fluid buildup, loose flaps of cartilage, or chips of cartilage loose within the ... The last lesion is called osteochondrosis dissecans (OCD), and can develop further into degenerative joint disease, such as ... Osteochondrosis can also contribute to navicular syndrome and Wobbler disease. Because most horses, especially Hanoverians, ...
Cocaine may also increase risk for autoimmune disease and damage nasal cartilage. Abuse of methamphetamine produces similar ... Moderate coffee consumption may decrease the risk of cardiovascular disease, and it may somewhat reduce the risk of type 2 ... Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... Muriel P, Arauz J (2010). "Coffee and liver diseases". Fitoterapia. 81 (5): 297-305. doi:10.1016/j.fitote.2009.10.003. PMID ...
Because Sulfs were important in normal chondrogenesis, they were investigated in cartilage diseases. Expression patterns of ... Because of this role, Sulfs may have a direct role in diseases such as muscular dystrophy. QSulf1 was used as a tool to either ... Zhao W, Sala-Newby GB, Dhoot GK (December 2006). "Sulf1 expression pattern and its role in cartilage and joint development". ... Additionally, this emphasizes how small changes in HS sulfation patterns have major impacts in health and disease. The first ...
Inflammation of the cartilage of the ear is a specific symptom of the disease and affects most people.[3] It is present in ... Autoimmune diseases. Systemic lupus erythematosus,[5][15] Systemic scleroderma,[5] Mixed connective tissue disease,[5][15] ... Though any cartilage in the body may be affected in persons with relapsing polychondritis, in many cases the disease affects ... Cartilage inflammation (technically known as chondritis) that is relapsing is very characteristic of the disease and is ...
Hunter W (1743) "On the structure and diseases of articulating cartilages." Trans R Soc Lond 42B:514-21 Pridie K (1959) A ... Karli D Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal ... Michael Freeman Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous ... a cell-based articular cartilage repair procedure that aims to provide complete hyaline repair tissues for articular cartilage ...
Rheumatoid arthritis is a disease where the body attacks its own cartilage and destroys it. In each of these cases, cartilage ... has damaged or worn out cartilage. Normally the ends of the bone are covered with hyaline articular cartilage, a surface so ... glucosamine sulfate is an effective preserver of cartilage. Another way to prevent the further loss of cartilage would be to ... In arthritis, this cartilage is progressively lost, exposing the bone beneath. Shoulder arthritis is characterized by pain, ...
"Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells ... The main functions of adult stem cells are to replace cells that are at risk of possibly dying as a result of disease or injury ... Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, Ohgushi H (2007). "Repair of articular cartilage defects in the patello- ... "Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells, platelate ...
... in both healthy cartilage and arthritic diseases. Her work focuses on the structure and function of the cartilage molecules, ... Her studies on cartilage biology and arthritic diseases will identify new target molecules and/or activities, for the ... She and her team have generated unique mice for evaluating cartilage damage in arthritic disease. Her work showing that ADAMTS- ... of Australia who has an established career researching arthritis and cartilage biology in health and disease. She is Professor ...
"Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells ... They can develop into various tissue types including skin, cartilage, cardiac tissue, nerves, muscle, and bone. The cells also ... Mahla RS (2016). "Stem cells application in regenerative medicine and disease threpeutics". International Journal of Cell ... where the cells prolonged survival of the animals by slowing down the progression of the disease. The same effect was observed ...
Primrose syndrome, a rare genetic disease in which cartilage becomes ossified.. ReferencesEdit. Wikimedia Commons has media ... Osteogenesis imperfecta, a juvenile bone disease. *Fibrodysplasia ossificans progressiva, an extremely rare genetic disease ... calcium-based minerals were stored in cartilage and bone was an exaptation development from this calcified cartilage.[3] ... Cartilage is progressively eroded and replaced by hardened bone, extending towards the epiphysis. A perichondrium layer ...
... is involved in the pathophysiology of several bone and cartilage diseases such as osteoarthritis, ... In Alzheimer's disease (AD), the expression of A1 and A2A receptors in the frontal cortex of the human brain is increased, ... Following tissue injury in patients with Graft-versus-host disease (GVHD), ATP is released into the pertioneal fluid. It binds ... Istradefylline - Antagonist of the adenosine A2A receptor, used in the treatment of Parkinson's disease as an adjunct to L-DOPA ...
"Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia". Cell. 104 (2): 195- ... The RMRP gene is untranslated, i.e., it encodes an RNA not a protein.[supplied by OMIM] It is associated with cartilage-hair ... Hermanns P, Tran A, Munivez E, Carter S, Zabel B, Lee B, Leroy JG (October 2006). "RMRP mutations in cartilage-hair hypoplasia ... Bonafé L, Schmitt K, Eich G, Giedion A, Superti-Furga A (February 2002). "RMRP gene sequence analysis confirms a cartilage-hair ...
... is linked to mutations in the RNA component of RNase MRP, which causes pleiotropic human disease cartilage-hair ... 26 January 2001). "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia". ... FAM221B has two consistent non-synonymous amino acid variations associated with the disease. In acute lymphoblastic leukemia ...
Mutations in the RNA component of RNase MRP cause cartilage-hair hypoplasia, a pleiotropic human disease. Responsible for this ... Mutations in the RNA component of RNase MRP cause cartilage-hair hypoplasia(CHH), a pleiotropic human disease. Two categories ... These two diseases do differ in that MDWH lacks immunodeficiency and other skeletal features found in CHH patients. AD is an ... RMRP was the first non-coding nuclear RNA gene found to cause disease. RNAase MRP and its role in pre-rRNA processing has been ...
Osteochondrodysplasia, a disorder related to the development of bone and cartilage, can also cause this disease.[citation ... such as in the case of elderly patients suffering from the degenerative disease of bones and cartilage. The primary objective ... Docti Posture MedEd at Loyola medicine/pulmonar/diseases/pul22.htm Bracing adolescents with idiopathic scoliosis; Journal of ... the disease is in progression stage, and the quality of life has degraded to an extent where conservative treatments can no ...
Mutations within RNase MRP have been shown to cause cartilage-hair hypoplasia, a disease associated with an array of symptoms ... "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia". Cell. 104 (2): 195- ... Non-coding RNAs are crucial in the development of several endocrine organs, as well as in endocrine diseases such as diabetes ... As with proteins, mutations or imbalances in the ncRNA repertoire within the body can cause a variety of diseases. Many ncRNAs ...
This was the first time this abnormal disease affecting cartilage and connective tissue was observed and characterised. His ... comparison of diseases common to humans and animals Virchow's disease, leontiasis ossea, now recognized as a symptom rather ... He went further and stated that the cell was the basic unit of the body that had to be studied to understand disease. Although ... He proposed that diseases came from abnormal activities inside the cells, not from outside pathogens. He believed that ...
... (WCS) is a disease of the airways where cartilage in the bronchi is defective. It is a form of ... Persistent cough Wheeze Impaired lung function It is thought to result from a deficiency of cartilage formation in the 4th to ... This was previously attempted in a patient with end-stage lung disease secondary to WCS. Although the patient did not have ... Williams HE, Landau LI, Phelan PD (June 1972). "Generalized bronchiectasis due to extensive deficiency of bronchial cartilage ...
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The ... 2001). "Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis ... which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal ... "Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with ...
... some physicians view costochondritis and Tietze's syndrome as separate disease states due to the absence of costal cartilage ... Costochondral cartilage. References[edit]. *^ a b c Mayo Clinic Staff (2012). "Costochondritis Definition". Mayo Clinic. ... Arthritis Associated with Systemic Disease, and Other Arthritides Harrison's principles of internal medicine (17th ed.). New ... and often temporary inflammation of the costal cartilage, the structure that connects each rib to the sternum at the ...
The inappropriate activity of aggrecanase is a mechanism by which cartilage degradation occurs in diseases such as arthritis. ... Aggrecanases act on large proteoglycans known as aggrecans, which are components of connective tissues such as cartilage. ...
... administration of glucosamine in German Shepherds have reduced symptoms of degenerative joint disease and accelerated cartilage ... a degenerative disease of the pancreas. It is estimated that 1% of the UK GSD population suffers from this disease.[65] ... "Von Willebrand's Disease (vWD): A Type of Hemophilia in Dogs". Drs. Foster & Smith, Inc. Retrieved 10 May 2009.. ... Glucosamine is an amino-monosaccharide that naturally occurs in all tissues, particularly in articular cartilage of joints and ...
Cocaine may also increase risk for autoimmune disease[17][18][19] and damage nasal cartilage. Abuse of methamphetamine produces ... Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... Muriel P, Arauz J (2010). "Coffee and liver diseases". Fitoterapia. 81 (5): 297-305. doi:10.1016/j.fitote.2009.10.003. PMID ... Abuse of cocaine, depending upon route of administration, increases risk of cardiorespiratory disease, stroke, and sepsis.[14] ...
Osteoarthritis is a degenerative disease marked by the breakdown of cartilage between joints resulting in painful bone-to-bone ... First, the joint is continually repairing itself and laying down new cartilage. However, cartilage repair is a relatively slow ... Reasonable exercise stimulates cartilage growth and reduces degeneration, and also regular walks taken in the early stages of ... While bones provide the strength necessary to support body weight, cartilage ensures a smooth fit and a wide range of motion. ...
... (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone ... Ehlers-Danlos syndrome Hemochromatosis and Wilson's disease Inflammatory diseases (such as Perthes' disease), (Lyme disease), ... a) cartilage erosion (b)cartilage ulceration (c)cartilage repair (d)osteophyte (bone spur) formation. Histopathology of ... Marfan syndrome Obesity Joint infection While osteoarthritis is a degenerative joint disease that may cause gross cartilage ...
... while imbalance results in disease. Such disease-inducing imbalances can be adjusted and balanced using traditional herbs, ... Examples include immuno-augmentation therapy, shark cartilage, bioresonance therapy, oxygen and ozone therapies, and insulin ... A belief that a substance that causes the symptoms of a disease in healthy people cures similar symptoms in sick people.[n 8] ... Treatments for severe diseases such as cancer and HIV infection have well-known, significant side-effects. Even low-risk ...
... (OA) is a teep o jynt disease that results frae brakdoun o jynt cartilage an unnerleein bane.[5] The maist ... "National Institute of Arthritis and Musculoskeletal and Skin Diseases. April 2015. Archived frae the oreeginal on 18 May 2015. ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545-602. doi:10.1016/S0140-6736(16) ...
Brian Keith Hall (2005). Bones and cartilage: developmental and evolutionary skeletal biology. Academic Press. pp. 150-. ISBN ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ... Chondrocytes are only present in cartilage where they will produce cartilaginous matrix to maintain the structure. Sox9, L-Sox5 ...
hyoid cartilage division: In cases without mature ossification of the hyoid bone, the non-fused cartilage portion can be ... Thyroid disease. *Persistent thyroglossal duct. *Thyroglossal cyst. *Congenital hypothyroidism *Thyroid dysgenesis. *Thyroid ...
Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[8] Other kinds ... "Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125-139. doi:10.1016/j.numecd.2006.10.005. PMC 4426988. PMID ... Congenital diseases include Marfan syndrome and Ehlers-Danlos Syndrome.. *Myxomatous degeneration - a pathological weakening of ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... The new section will however contain cartilage rather than bone, and will never grow to the same length as the original tail. ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ... a common skin disease in snakes and lizards, will occur when ecdysis, or shedding, fails.[94] There are numerous reasons why ...
Diseases treated[edit]. *Thymoma and Thymic carcinoma: These tumors which arise from the thymus gland in the upper part of the ... Low grade sarcomas: Sarcoma is a cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive ... The goal of surgical cytoreduction is to remove all gross disease including tumors that are in resectable areas of the lung or ... There are other intra-abdominal malignancies that may cross the diaphragm and cause disease in the chest that could be ...
"Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells ... or re-grow cartilage tissue to replace missing or damaged cartilage. One cell-based replacement technique is called autologous ... Once cartilage damage is assessed there are two methods to access the joint to proceed with the AMIC surgery. First is to ... Articular cartilage, most notably that which is found in the knee joint, is generally characterized by very low friction, high ...
... coronary heart disease, dimension, osteoporosis, eye disease, stroke cancer and rheumatoid arthritis and the influence of ... connective tissue and cartilage. Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other ... The Centers for Disease Control and Prevention (2014). Children eating more fruit, but fruit and vegetable intake still too low ... Development of chronic disease has become closely related to the consumption of fruits and vegetables throughout childhood ( ...
They also have an internal structure of cartilage-like tissue, to which certain muscle groups are attached.[4] ... Several mites are external parasites, and some of them are carriers of disease (vectors). ...
The Russian surgeon Nikolaj Bogoraz performed the first reconstruction of a total penis using rib cartilage in a reconstructed ... Loss of the phallus from either disease or blood supply issues. *Cephalic vein thrombosis (blood clot) ...
Add to these factors disease and cardiac and respiratory illness. Eccentric training enables the elderly, and those with the ... and the articular cartilage.[8] In an experiment performed on rat muscles after twenty sessions of treadmill low intensity ... Rooyackers, J. (2003). "Eccentric exercise training in patients with chronic obstructive pulmonary disease". Rehabilitation ... Journal of Chronic Obstructive Pulmonary Disease. 8 (4): 270-274. doi:10.3109/15412555.2011.579926. PMID 21728805. S2CID ...
Chronic granulomatous disease: autosomal (NCF1) Chronic granulomatous disease: autosomal (NCF2) IL-12 and IL-23 β1 chain ... cartilage-hair hypoplasia, Schimke syndrome Hermansky-Pudlak syndrome type 2 Hyper-IgE syndrome Chronic mucocutaneous ... Such donor T-cells often cause acute graft-versus-host disease (GVHD), a subject of ongoing investigation. VSTs have been ... 2014). "Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological ...
"Centers for Disease Control and Prevention. Retrieved 2014-03-24.. *^ Rae, K; Orchard, J (May 2007). "The Orchard Sports Injury ... a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117-71. doi:10.1016/S0140-6736(14)61682 ...
... which can mean any disease causing scaly skin) in the Septuagint. While the condition may sometimes be a symptom of the disease ... absorption of nasal cartilage, affliction of knees and elbows, difficult and hoarse respiration, as well as anaesthesia."[8] ... The word leprosy comes from ancient Greek Λέπρα [léprā], "a disease that makes the skin scaly", in turn, a nominal derivation ... The Disease of the Soul: Leprosy in Medieval Literature (Ithaca: Cornell Press, 1974). ...
Bohlender, Jörg (2013). "Diagnostic and therapeutic pitfalls in benign vocal fold diseases". GMS Current Topics in ... thyroid cartilage, or cricothyroid membrane.[23] After VFSI, patients are recommended to take 1 to 7 days of vocal rest.[23] ... Diagnostic and therapeutic pitfalls in benign vocal fold diseases". Gms Current Topics in Otorhinolaryngology, Head and Neck ...
Other diseases[edit]. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... and cartilage.[21] ... Cardiovascular disease[edit]. A 2013 meta-analysis found no ... "Journal of Alzheimer's Disease. 29 (4): 711-26. doi:10.3233/JAD-2012-111853. PMC 3727637. PMID 22366772.. ... The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747 ...
Mitochondria is involved in Parkinson's disease. In idiopathic Parkinson's disease, the disease is commonly caused by ... Autophagy is constantly activated in normal cartilage but it is compromised with age and precedes cartilage cell death and ... Parkinson disease[edit]. Parkinson disease is a neurodegenerative disorder partially caused by the cell death of brain and ... "Autophagy in Stress, Development & Disease, 2003, Gordon Research Conference".. *^ "Autophagy in Health and Disease (Z3), 2007 ...
a b c d e f g h i j k l Hawke, M. (2003) Chapter 1: Diseases of the Pinna. Ear Disease: A Clinical Guide. Hamilton, Ontario. ... Stahl's deformity, pointed pinna due to an extra fold of cartilage[4] ...
vascular disease or severe neurologic disorders;. *previous arthrodesis of the ipsilateral hip or knee or severe deformities of ... Cartilage. *Articular cartilage repair *Microfracture surgery. *Knee cartilage replacement therapy. *Autologous chondrocyte ...
Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease ... "Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen ...
Hyaline cartilage is present in the bronchi, surrounding the smooth muscle layer. In the main bronchi, the cartilage forms C- ... It can have multiple variations and, although usually asymptomatic, it can be the root cause of pulmonary disease such as a ... The cartilage and mucous membrane of the primary bronchi are similar to those in the trachea. They are lined with respiratory ... As the cartilage decreases, the amount of smooth muscle increases. The mucous membrane also undergoes a transition from ...
... live in all of the oceans, particularly in tropical and warm subtropical waters. They are commonly found in the epipelagic zone, the top layer of the ocean to a depth of about 200 m (656 ft). Numerous morphological features give flying fish the ability to leap above the surface of the ocean. One such feature is fully broadened neural arches, which act as insertion sites for connective tissues and ligaments in a fish's skeleton. Fully broadened neural arches act as more stable and sturdier sites for these connections, creating a strong link between the vertebral column and cranium.[10] This ultimately allows a rigid and sturdy vertebral column (body) that is beneficial in flight. Having a rigid body during glided flight gives the flying fish aerodynamic advantages, increasing its speed and improving its aim.[10] Furthermore, flying fish have developed vertebral columns and ossified caudal complexes.[11] These features provide the majority of strength to the flying fish, allowing them ...
This was the first time this abnormal disease affecting cartilage and connective tissue was observed and analysed. His ... Anti-germ theory of diseasesEdit. Virchow did not believe in the germ theory of diseases, as advocated by Louis Pasteur and ... Virchow's disease, leontiasis ossea, now recognized as a symptom rather than a disease ... Murray, edited by Edward J. Huth, T. Jock (2006). Medicine in Quotations: Views of Health and Disease Through the Ages (2 ed ...
Mouth diseases include tongue diseases and salivary gland diseases. A common gum disease in the mouth is gingivitis which is ... The epiglottis is a flap of elastic cartilage attached to the entrance of the larynx. It is covered with a mucous membrane and ... It can also arise as a result of other gastrointestinal diseases such as coeliac disease. Coeliac disease is an autoimmune ... Crohn's disease is a common chronic inflammatory bowel disease (IBD), which can affect any part of the GI tract,[45] but it ...
Disease. Target antigen. Effects. Allergic contact dermatitis[1]. Environmental chemicals, like urushiol (from poison ivy and ... Chronic arthritis, inflammation, destruction of articular cartilage and bone. Tuberculin reaction (Mantoux test)[3]. Tuberculin ... Inflammatory bowel disease[1]. Enteric microbiota and/or self antigens. Hyperactivation of T-cells, cytokine release, ... Various, depending on underlying disease. Walled off lesion containing macrophages and other cells. ...
Adults with cerebral palsy may have ischemic heart disease, cerebrovascular disease, cancer, and trauma more often.[44] Obesity ... articular cartilage may atrophy,[21]:46 leading to narrowed joint spaces. Depending on the degree of spasticity, a person with ... Pediatric and Adult Nutrition in Chronic Diseases, Developmental Disabilities, and Hereditary Metabolic Disorders: Prevention, ... The spastic diplegia form of CP came to be known as Little's disease.[6] At around this time, a German surgeon was also working ...
"An Introduction to Proteins" from HOPES (Huntington's Disease Outreach Project for Education at Stanford) ... collagen and elastin are critical components of connective tissue such as cartilage, and keratin is found in hard or ... "Diet and skin disease in dogs and cats". The Journal of Nutrition. 128 (12 Suppl): 2783S-89S. doi:10.1093/jn/128.12.2783S ...
However, this disease highlights the importance of the thymus in prevention of autoimmunity. This disease is caused by ... that stretch from below the thyroid in the neck to as low as the cartilage of the fourth rib. It lies beneath the sternum, ... Patients with APECED develop an autoimmune disease that affects multiple endocrine tissues. A GVHD-like disease called thymoma- ... The end result is a disease virtually indistinguishable from GVHD. Myasthenia gravis is an autoimmune disease caused by ...
Pigmentation may be noted in the cartilage of the ear as well as other cartilage, and the sclera and corneal limbus of the eye ... Very occasionally the disease appears to be transmitted in an autosomal dominant fashion, where a single abnormal copy of HGD ... Valvular heart disease, mainly calcification and regurgitation of the aortic and mitral valves, may occur, and in severe and ... Alkaptonuria is a rare disease; it occurs in one in 250,000 people, but is more common in Slovakia and the Dominican Republic. ...
A deficiency or malfunction of any of the enzymes participating in cartilage proteoglycan metabolism may lead to severe disease ... Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a ... Metabolism of Cartilage Proteoglycans in Health and Disease. Demitrios H. Vynios1. 1Biochemistry, Biochemical Analysis and ... Metabolism of Cartilage Proteoglycans in Health and Disease,. BioMed Research International,. vol. 2014. ,. Article ID 452315 ...
Adverse Events of Adoptively Transferred CD8 T Cells Targeting NY-ESO-1+ Tumors Given Alone and in Combination with Antigen-Specific ...
... ground breaking research shows promising advancements in the battle against articular cartilage disease. A new ... Articular cartilage disease is a large and growing problem as the US population ages. Orthopedic surgeons are able to visibly ... Articular cartilage disease is a large and growing problem as the US population ages. Orthopedic surgeons are able to visibly ... New, ground breaking research shows promising advancements in the battle against articular cartilage disease. A new study, ...
span,,b,:,/b, Osteoarthritis and rheumatoid arthritis are common cartilage and joint diseases that globally affect more than ... Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases Int J Mol Sci. 2020 Feb 17;21(4 ... Osteoarthritis and rheumatoid arthritis are common cartilage and joint diseases that globally affect more than 200 million and ... In these ways, investigation of cartilage and chondrocyte diseases at molecular and cellular levels has enlightened the ...
Interaction of cartilage collagen fibrils and proteoglycans: Application of fluorescent labelling techniques for assay of ... Cartilage of the patella and its degeneration: Topographical variation of the glycosaminoglycan content ... Immunocytochemical and historical studies of a reversible transformation of chondrocytes in degraded cartilage matrix to a ... Effect of antiproteoglycan serum and Hyaluronidase on metabolic functions of calf cartilage cells in vitro ...
Cartilage metabolism--a response. Message subject: (Your Name) has forwarded a page to you from Annals of the Rheumatic ... Your Name) thought you would like to see this page from the Annals of the Rheumatic Diseases web site. ...
... and Hyogo College of Medicine scientists find a potential treatment for people suffering from currently incurable diseases. ... IPS study offers hope to those with rare bone, cartilage diseases. Sorry, but your browser needs Javascript to use this site. ... The scientists tried to turn the stem cells into cartilage, but confirmed that they could not make normal cartilage cells. ... a group of rare diseases that affect skeletal growth through abnormalities in bone and cartilage, particularly types known as ...
"Cartilage Diseases" by people in Harvard Catalyst Profiles by year, and whether "Cartilage Diseases" was a major or minor topic ... "Cartilage Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Cartilage Diseases" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Cartilage Diseases". ...
29 Studies found for: Recruiting, Not yet recruiting, Available Studies , Cartilage Diseases ...
Transplant of lab-grown cartilage is a first in joint-healing studies, says senior author Kyriacos Athanasiou, UCI ...
CIRM funds many projects seeking to better understand bone related diseases including osteoporosis, osteoarthritis and ... Home › Osteoporosis, Bone and Cartilage Disease Fact Sheet. Osteoporosis, Bone and Cartilage Disease Fact Sheet. CIRM funds ... CIRM Grants Targeting Bone & Cartilage Disease. Researcher name Institution Grant Title Grant Type Award Amount ... Osteoarthritis is a disease that affects the cartilage in joints. It is one of the most common forms of disability, effecting ...
... Publication Year: 2012 ... Skeletal Biology and Medicine II: Bone and cartilage homeostasis and bone disease. Description. This volume presents ... Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, ... Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, ...
Find out information about Cartilage diseases. flexible semiopaque connective tissue connective tissue, supportive tissue ... widely distributed in the body, characterized by large amounts of intercellular... Explanation of Cartilage diseases ... cartilage. (redirected from Cartilage diseases). Also found in: Dictionary, Thesaurus, Medical.. Related to Cartilage diseases ... Cartilage is modified in several ways. In elastic cartilage, elastic fibers in the matrix increase resilience, as in cartilages ...
Cartilage of the medial coronoid process (MCP) and humeral trochlea (HT) were scored on a 0-3 scale using anatomical MRI ... Cartilage of the medial coronoid process (MCP) and humeral trochlea were scored on a 0-3 scale using anatomical MRI sequences. ... Cartilage pathology was graded arthroscopically using a modified Outerbridge score (MOS) by a surgeon blinded to MRI assessment ... Cartilage pathology was graded arthroscopically using a modified Outerbridge score (MOS) by a surgeon blinded to MRI assessment ...
During follow up, seven disease related deaths were observed; the expected number was 0.8 (table 2), the disease mortality in ... METHODS The overall and cause specific disease mortality rates in patients with CHH, and the disease mortality rate in 194 ... 1980) Cartilage-hair hypoplasia. in Population structure and genetic disorders. eds Eriksson AW, Forsius H, Nevanlinna HR, ... 1992) Cartilage-hair hypoplasia in Finland: epidemiological and genetic aspects of 107 patients. J Med Genet 29:652-655. ...
... cartilage, disease, disorder, en, human, ligaments, organs, purpose, science , Glogster EDU - Interactive multimedia posters ... Diseases/DisordersOsteoporosis- the loss of bone tissue, particularly among the elderly. Bone loses calcium, becomes thinner, ... produce white and red blood cells Cartilage- an important connective tissue that supports the structure of many body parts and ...
Bone and Cartilage: from Development to Human Diseases. Suzhou, China. November 3-7,2014 Abstract Deadline extended to: ... We are pleased to announce the Cold Spring Harbor Asia conference on Bone and Cartilage: from Development to Human Diseases ... Abstract title:Imaging bone vessels for a better understanding of metabolic bone diseases. Natalie Sims, ST Vincents Institute ... Abstract title:Global cues orient planar cell polarity in the developing long bone cartilage ...
Temporal cartilage repair pattern following subchondral drilling. The outcome of articular cartilage repair was assessed at ... Subchondral drilling, a widely applied clinical technique to treat small cartilage defects, does not yield cartilage ... 2016b). Role of the subchondral bone in articular cartilage degeneration and repair. J. Am. Acad. Orthop. Surg. 24, e45-e46. ... 2012). The cartilage-bone interface. J. Knee Surg. 25, 85-97. doi:10.1055/s-0032-1319782. ...
Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage ... Macroscopic and histopathological evaluation of cartilage lesions and immunohistochemical analysis of cartilage to assess ... This study is the first to demonstrate that a therapeutic intervention that can inhibit PAR-2 is associated with a disease- ... Treatment with BCD extract exerts a positive effect on the prevention of cartilage lesions induced by joint instability, and ...
Studies on cartilage and bone disease in Mucopolysaccharidoses and Mucolipidoses. Publication. Publication. Studies over ... Oussoren, E. (2018, December 4). Studies on cartilage and bone disease in Mucopolysaccharidoses and Mucolipidoses. Erasmus ... Mucopolysaccharidosis, MPS, Mucolipidosis, ML, bones, cartilages, fetal origin, hip, acetabulum and craniosynostosis ... The aim of this thesis is to create a better understanding of the etiology and pathophysiology of cartilage and bone ...
... Lohmander, L. S ... articular cartilage, cartilage matrix, osteoarthritis, collagen type 2. in Journal of Anatomy. volume. 184. issue. 3. pages. 16 ... Articular cartilage and osteoarthrosis. The role of molecular markers to monitor breakdown, repair and disease}, volume = {184 ... article{4cf8d658-8dbe-46f0-bd27-4d094243136e, author = {Lohmander, L. S.}, issn = {0021-8782}, keyword = {articular cartilage, ...
... Show full item ... Immunodeficiency in cartilage-hair hypoplasia : correlation with pulmonary disease, infections and malignancy. ... and pulmonary disease (n = 4). Increased mortality was associated with severe short stature at birth, Hirschsprung disease, ... Infectious diseases Rights: This publication is copyrighted. You may download, display and print it for Your own personal use. ...
Annals of the Rheumatic Diseases}, title = {Cartilage macromolecules in knee synovial fluid. Markers of the disease course in ... Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis. Saxne, ... Annals of the Rheumatic Diseases. volume. 56. pages. 751 - 753. publisher. British Medical Association. ISSN. 1468-2060. ... Tore LU and Lindqvist, Elisabet LU (1997) In Annals of the Rheumatic Diseases 56. p.751-753 *Mark ...
Your Name) has sent you a message from Disease Models & Mechanisms Message Body (Your Name) thought you would like to see the ... Disease Models & Mechanisms 2018 11: dmm033092 doi: 10.1242/dmm.033092 Published 6 July 2018 ... Disease Models & Mechanisms 2018 11: dmm033092 doi: 10.1242/dmm.033092 Published 6 July 2018 ... Disease Models & Mechanisms 2018 11: dmm033092 doi: 10.1242/dmm.033092 Published 6 July 2018 ...
Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological ... Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological ... Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological ... Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological ...
Finally, before the compositional status of cartilage can be put to use as a biomarker for clinical trials involving disease- ... Compositional Magnetic Resonance Imaging Measures of Cartilage - Endpoints for Clinical Trials of Disease-modifying ... Compositional Magnetic Resonance Imaging Measures of Cartilage - Endpoints for Clinical Trials of Disease-modifying ... Compositional Magnetic Resonance Imaging Measures of Cartilage - Endpoints for Clinical Trials of Disease-modifying ...
Soft tissue surgery refers to any type of surgery for treatment of diseases which are not orthopaedic or neurologic. As such, ... Radiographic Arthrosis Correlate With Cartilage Pathology in Labrador Retrievers Affected by Medial Coronoid Process Disease?. ... Home , Research Centre , Does Radiographic Arthrosis Correlate With Cartilage Pathology in Labrador Retrievers Affected by ... The arthroscopic report was used to generate a composite cartilage score (CCS; 0 = normal, 1 = mild, 2 = moderate, 3 = severe) ...
Cartilage to bone transitions in health and disease. In: Journal of Endocrinology. 2013 ; Vol. 219, No. 2. pp. R1-R12. ... title = "Cartilage to bone transitions in health and disease",. author = "KA Staines and AS Pollard and IM McGonnell and C ... Cartilage to bone transitions in health and disease. / Staines, KA; Pollard, AS; McGonnell, IM; Farquharson, C; Pitsillides, AA ... 14796805 - Journal of Endocrinology] Cartilage to bone transitions in health and diseaseFinal published version, 347 KBLicence ...
cartilage disease. Model name. Publication. Status. Proctor2013 - Cartilage breakdown, interventions to reduce collagen release ... cartilage disease. Model name. Publication. Status. Proctor2013 - Cartilage breakdown, interventions to reduce collagen release ... Crohns disease. Model name. Publication. Status. Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6 Antibody (BIOMD0000000535) ... Crohns disease. Model name. Publication. Status. Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6 Antibody (BIOMD0000000535) ...
  • The most common is hyaline cartilage, which composes the pre-skeletal model and is found in adults at the joints, in the nose, and in several internal organs. (
  • Where cartilage joins bones tightly at certain joints with limited mobility, for example, at the pubic symphysis and between vertebrae, the matrix of fibrocartilage contains prominent collagen fibers and has less proteoglycan than the typical hyaline variety. (
  • At sites of calcification, invading cells destroy the cartilage and mostly replace it by bone, leaving permanent hyaline cartilage only at the joint or articular surfaces, in some ribs, and, until maturity, at growth plates set back from the joints and perpendicular to the long axis of limb bones. (
  • There are three main types of cartilage in the body, hyaline, fibro, and elastic. (
  • Hyaline (or articular) cartilage surrounds the outer surface of the bones at the joint sites. (
  • This is a very common procedure and has good results however the new cartilage lacks some of the biomechanical properties of hyaline cartilage, especially its ability to withstand load. (
  • This seem to be the choice of treatment for larger defects and italso seem to provide a more hyaline type cartilage which is more durable. (
  • Our aim i s to demonstrate that engineered cartilage will support viability and matrix production from mammalian chondrocytes using a young bovine source, establish tissue growth which will be qualitatively similar to that produced from avian cells under comparable conditions, and establish maintenance of the hyaline phenotype. (
  • Cartilage is found in many places in the body and is classified as either "hyaline," "elastic," or "fibrous" cartilage. (
  • In hyaline cartilage, type II collagen makes up 40 percent of its dry weight and is arranged in cross-striated fibers, 15-45 nanometers in diameter that do not assemble into large bundles. (
  • Fibrous cartilage contains more collagen than hyaline cartilage, and elastic cartilage, as its name implies, contains elastic fibers, which lend it a greater deal of flexibility. (
  • Hyaline cartilage is the most abundant type of cartilage. (
  • It is avascular hyaline cartilage that is made predominantly of type II collagen. (
  • Hyaline cartilage is found lining bones in joints (articular cartilage or, commonly, gristle) and is also present inside bones, serving as a center of ossification, or bone growth. (
  • In addition, hyaline cartilage forms most of the embryonic skeleton. (
  • 2 parts by weight of dexamethasone for the treatment, prevention, or alleviation of hyaline cartilage disease or injury. (
  • Osteoarthrithis is a multifactorial and heterogeneous disease associated with a progressive loss of hyaline articular cartilage. (
  • The nasal cartilages are made up of a flexible material called hyaline cartilage (packed collagen) in the distal portion of the nose. (
  • The septal nasal cartilage is a flat, quadrilateral piece of hyaline cartilage that separates both nasal cavities from one another. (
  • Like the septal nasal cartilage, the lateral nasal cartilage is composed of hyaline cartilage. (
  • Hyaline cartilage provides form and flexibility within a specific structure. (
  • Composed of hyaline cartilage, these structures are very thin and folded to form the lateral and medial crus. (
  • Cartilage is classified in three types, elastic cartilage, hyaline cartilage and fibrocartilage, which differ in relative amounts of collagen and proteoglycan. (
  • Also, because hyaline cartilage does not have a blood supply, the deposition of new matrix is slow. (
  • For optimal joint function, it is important to beat inflammation wherever possible-inflammation is the primary source of collagen and, by extension, cartilage breakdown. (
  • It is known that the composition of cartilage is crucial for its function and forming the complex matrix network: This matrix consists primarily of collagen and acidic polysaccharides (the glycosaminoglycans) that form in combination with proteins the so-called proteoglycans. (
  • Cartilage is composed of collagen (type II) and elastic fibers. (
  • This molecule fills all the spaces between the collagen fibers and holds water, thus plumping out the extracellular matrix and giving articular cartilage its resistance to compression and its resilience (ability to spring back into shape after load). (
  • On LM, 69% of all cartilage canals were surrounded by a ring of matrix that stained intensely eosinophilic and consisted of collagen fibres on TEM that were confirmed to be collagen type I by immunohistochemistry. (
  • While cartilage is made up of proteoglycans and type II collagen, tendon and bone are composed primarily of type I collagen. (
  • Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondroblasts and begins secreting the molecules (aggrecan and collagen type II) that form the extracellular matrix. (
  • A deficiency or malfunction of any of the enzymes participating in cartilage proteoglycan metabolism may lead to severe disease state. (
  • According to this, the main proteoglycan in cartilage was termed aggrecan, since it can form aggregates with hyaluronan and link protein. (
  • Another technique, dGEMRIC, is sensitive to cartilage proteoglycan GAG content and may predict the development of OA 11 . (
  • In human osteoarthritis and animal models of degenerative joint disease, damage to the structure of cartilage proteoglycan is a central event. (
  • Objectives To identify changes in the expression patterns of enzymes involved in chondroitin sulfate (CS) glycosaminoglycan (GAG) metabolism in articular cartilage proteoglycan (PG) isolated from adolescent patients with Kashin-Beck disease (KBD). (
  • Cartilage is composed of specialized cells called chondrocytes that produce a large amount of collagenous extracellular matrix, abundant ground substance that is rich in proteoglycan and elastin fibers. (
  • The main proteoglycan in cartilage is aggrecan, which, as its name suggests, forms large aggregates with hyaluronan. (
  • This non-ablative technology now allows us to selectively target and remove damaged tissue without causing necrosis in the contiguous cartilage tissue surrounding the lesion. (
  • Temporary cartilage makes up the skeletal system of the fetus and the infant, forming a model for later replacement by bone bone, hard tissue that forms the skeleton of the body in vertebrate animals. (
  • Diseases/DisordersOsteoporosis- the loss of bone tissue, particularly among the elderly. (
  • Defects of the articular cartilage, the gliding tissue that covers the ends of articulating bones in all joints, do not heal. (
  • Soft tissue surgery refers to any type of surgery for treatment of diseases which are not orthopaedic or neurologic. (
  • Pathological processes involving the chondral tissue (CARTILAGE). (
  • cartilage to bone transitions in health and disease Considered a connective tissue, cartilage is a flexible, white substance that's similar. (
  • Cartilage is a tough, flexible connective tissue, that reduces friction between joints, holds bones together, and helps support weight. (
  • Most people associate cartilage with their earlobes or nose, but this soft, flexible tissue is found all throughout the body. (
  • Cartilage has practically zero regenerative potential in adulthood, so once it's injured or gone, what we can do for patients has been very limited," said assistant professor of surgery Charles K.F. Chan, PhD. "It's extremely gratifying to find a way to help the body regrow this important tissue. (
  • This is because the cartilage tissue is a different and tougher tissue to pierce through than an earlobe, so it is a bit more painful as a result. (
  • Cartilage covers the ends of the bones acting as a weight bearing, low friction, wear resistant tissue. (
  • Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. (
  • Cartilage is a type of dense connective tissue found in vertebrates , as well as such invertebrates as horseshoe crabs, marine snails , and cephalopods . (
  • Much like other connective tissue , cartilage is composed of cells , fibers, and a matrix. (
  • During embryonic development, cartilage is enclosed in a dense connective tissue called the perichondrium, which also contains the cartilage cell precursors ( chondroblasts ). (
  • Solidification of a chitosan-glycerol phosphate/blood implant in microfracture defects improved cartilage repair compared with microfracture alone by increasing the amount of tissue and improving its biochemical composition and cellular organization. (
  • Our understanding of the pathogenesis of human diseases such as diabetes, multiple sclerosis, retinopathy of prematurity and osteoporosis has been advanced because of such experiments, and better drug treatment of disorders such as osteoarthritis has been made possible with the use of human fetal tissue. (
  • Polychondrosis is a disease in which cartilage - the tissue that protects bones and joints - becomes inflamed. (
  • Biomedical engineers at the University of California, Davis, have created a lab-grown tissue similar to natural cartilage by giving it a bit of a stretch. (
  • The tissue, grown under tension but without a supporting scaffold, shows similar mechanical and biochemical properties to natural cartilage. (
  • These flaps of cartilage rub against underlying tissue, causing pain, lameness, and eventually degenerative joint disease. (
  • The body will often attempt to compensate for the damaged cartilage by forming scar tissue or adding bone to the affected area. (
  • Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. (
  • This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engineering and regenerative medicine. (
  • Cartilage (cartilaginous tissue) is a resilient and smooth elastic tissue, rubber-like padding that covers and protects the ends of long bones at the joints and nerves, and is a structural component of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components. (
  • Just by removing senescent cells, you could stimulate new tissue production," says Jennifer Elisseeff, senior author of the cartilage paper and a biomedical engineer at Johns Hopkins University in Baltimore, Maryland. (
  • Cartilage is a specialized type of tissue found in joints and areas that two bones come together. (
  • Surgery can repair and sometimes generate regrowth of some cartilage repair tissue. (
  • Cartilage is a soft tissue that surrounds the ends of some bones and forms both sides of a joint. (
  • What are effects of disease on connective tissue 2(cartilage)? (
  • It is a kind of elastic, gristly, smooth and shiny material made of connective tissue, whose purpose is to allow movement without friction, When the cartilage has been 'eaten away' by constant and precocious wear and tear, its surface becomes dull and roughened. (
  • Articular cartilage defects may initiate osteoarthritis. (
  • Subchondral drilling, a widely applied clinical technique to treat small cartilage defects, does not yield cartilage regeneration. (
  • Subchondral drilling led to improved repair outcome compared with defects that were untreated or treated with abrasion arthroplasty for cartilage repair in multiple translational models. (
  • These results have important implications for future investigations aimed at an enhanced translation into clinical settings for the treatment of cartilage defects, highlighting the importance of considering specific aspects of modifiable variables such as improvements in the design and reporting of preclinical studies, together with the need to better understand the underlying mechanisms of cartilage repair following subchondral drilling. (
  • Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis. (
  • The clinical applications of stem cell therapy is still at an early stage, but shows much promise, particularly in the management of cartilage defects. (
  • Microfracture is a surgical procedure that is used to treat focal articular cartilage defects. (
  • Abnormalities or defects in the nasal cartilages affect airflow through the nasal cavity, resulting in respiratory issues. (
  • Cartilage defects, the most common disease of joints, can cause swelling, pain, and subsequent loss of joint function [ 1 ]. (
  • Autologous chondrocyte implantation (ACI) has been applied widely with confirmed clinical effects in terms of repairing cartilage defects [ 5 , 6 ]. (
  • Following a meticulous removal of the calcified cartilage layer, the exposed subchondral bone plate on the base of the defect is penetrated by the custom-made cutting tip of the instrument to a certain depth at a high speed of approximately 10,000 to 400,000 rpm ( Fincham and Jaeblon, 2011 ). (
  • In the MIA in vivo OA model, administered orally at 500 mg/kg, UP1306 resulted in reductions of 17.5%, 29.0%, 34.4%, 33.5%, and 40.9% through week 1-5 in pain sensitivity, statistically significant improvements in articular cartilage matrix integrity, and minimal subchondral bone damage. (
  • Articular cartilage, subchondral bone, synovium, and infrapatellar fat pad (IPFP) are joint tissues that may harbor senescent cells and secrete a senescence-associated secretory phenotype (SASP) induced by aging or trauma. (
  • Examples are the various mucopolysaccharidoses (MPS), which constitute a family of lysosomal storage diseases characterized by deficiencies in lysosomal hydrolases responsible for the degradation of GAGs (mucopolysaccharides) [ 8 ]. (
  • Osteoarthritis is the most common joint disorder, characterized by an imbalance between synthesis and degradation of the articular cartilage with destruction of the joint [ 1 ]. (
  • Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive articular cartilage degradation manifested with significant functional impairment in consort with signs and symptoms of inflammation, stiffness, and loss of mobility. (
  • Our study is the first to demonstrate that human chondrocyte cells are permissive to RRV infection, support the production of infectious virus, and produce soluble factors including HPSE, which may contribute to joint degradation and the pathogenesis of disease. (
  • To determine whether assessment of morphological MRI sequences or delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) would have strong correlations with arthroscopic assessment of cartilage pathology in dogs with naturally occurring medial compartment pathology of the elbow. (
  • Cartilage pathology was graded arthroscopically using a modified Outerbridge score (MOS) by a surgeon blinded to MRI assessment. (
  • There is great variability in the character and severity of pathology affecting dogs with medial compartment disease of the elbow. (
  • This is clinically relevant because approximately 50% of dogs with medial coronoid disease have some pathology of cartilage on the HT and there are a growing number of surgical options available for treating dogs when pathology is not limited solely to the MCP ( 3 - 7 ). (
  • Of these, only arthroscopy provides an ability to assess the articular cartilage and is generally considered the gold standard for assessment of pathology in the canine elbow in dogs with MCP disease ( 2 , 9 , 10 ). (
  • Does Radiographic Arthrosis Correlate With Cartilage Pathology in Labrador Retrievers Affected by Medial Coronoid Process Disease? (
  • To compare radiographic elbow arthrosis with arthroscopic cartilage pathology in Labrador retrievers with elbow osteoarthritis secondary to medial coronoid process (MCP) disease. (
  • NO in addition has long been regarded as a catabolic aspect that plays a part in the OA disease pathology by mediating several procedures, including apoptosis, and perpetuating the appearance of proinflammatory cytokines [1]. (
  • The morphology and pathology of hand joint cartilage were examined by histochemical staining. (
  • The Gordon Research Seminar on Cartilage Biology and Pathology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. (
  • The primary focus of this student run and organized meeting is to bring together young investigators from a variety of geographic and scientific backgrounds to further our understand of cartilage biology from the perspective of development, normal physiology, and pathology. (
  • Over recent years, the link between cartilage/bone development and cartilage pathology has been reinforced by numerous groups. (
  • This GRS will be held in conjunction with the "Cartilage Biology and Pathology" Gordon Research Conference (GRC). (
  • KYOTO - Scientists from Kyoto University and Hyogo College of Medicine have found that cholesterol-fighting statins might help treat people with rare bone and cartilage diseases via iPS cells made from their own bodies. (
  • Although the same genes are mutated, the symptoms widely range with the patient, making study and treatment difficult," explained Toguchida, who is also an orthopedic surgeon using iPS cell technology to study many bone and cartilage diseases. (
  • The present invention provides pharmaceutical compositions, and methods of preparation and use for the treatment, prevention or alleviation of bone and cartilage diseases or injuries and hair loss. (
  • Here, we performed a systematic review of the outcome of subchondral drilling for knee cartilage repair in translational animal models. (
  • Can knee cartilage regrow? (
  • Can Glucosamine Supplements Protect My Knee Cartilage from Osteoarthritis? (
  • A tear of the meniscus of the knee cartilage can often be surgically trimmed to reduce problems. (
  • Osteoarthritis is a disease that affects the cartilage in joints. (
  • Cartilage is also present at the joints joint, in anatomy, juncture between two bones. (
  • Some joints are immovable, e.g., those that connect the bones of the skull, which are separated merely by short, tough fibers of cartilage. (
  • The precarious physiological balance between chondrocytes and matrix materials in the heavily loaded articular cartilage breaks down in old age or in inflamed joints. (
  • Congenital arthrogryposis, a disease whose causes are still poorly understood, is a pathological disorders of the joints. (
  • Perhaps most importantly, cartilage serves as the protective cushion between bones and joints. (
  • Your joints and cartilages help you move around so easily that you do not even realize how big of a blessing they are. (
  • The TargetCaRe consortium aims to develop treatments for joint and intervertebral disc diseases by combining advanced drug delivery carriers with dedicated targeting tools, state of the art imaging techniques and expertise in biology of stem cells and joints. (
  • These diseases affect primarily the cartilage of the larger joints and destroy its macromolecular constituents. (
  • Cartilage neither heals nor regenerates after damage, so artificial cartilage could help many people with joints damaged by wear, injury or disease. (
  • Articular cartilage provides a smooth surface for our joints to move, but it can be damaged by trauma, disease or overuse. (
  • Artificial cartilage that could be implanted into damaged joints would have great potential to help people regain mobility. (
  • The irreversible destruction of the cartilage, tendon, and bone that comprise synovial joints is the hallmark of both rheumatoid arthritis (RA) and osteoarthritis (OA). (
  • MMP-1 is produced primarily by the synovial cells that line the joints, and MMP-13 is a product of the chondrocytes that reside in the cartilage. (
  • The mechanical properties of articular cartilage in load-bearing joints such as the knee and hip have been studied extensively at macro, micro, and nano-scales. (
  • Healthy cartilage helps decrease friction in joints, absorbs shock and protects the ends of the bone. (
  • Cartilage is the smooth substance lining most joints. (
  • Some of our joints are more prone than others to this disease, the more vulnerable being the hip, knee, and thumb joints. (
  • Relapsing polychondritis is a rare autoimmune rheumatic disorder characterized by episodes of painful, destructive inflammation of the cartilage and other connective tissues in many organs. (
  • The presence of so many varieties of tissues, connective tissues, and cartilage, all providing different functions and working together harmoniously-and with some cartilage needed by embryos to even give rise to bones in adults-reflects the intricacy and complex coordination in living organisms. (
  • Compared to other connective tissues, cartilage has a very slow turnover of its extracellular matrix and is documented to repair at only a very slow rate relative to other tissues. (
  • Macroscopic and histopathological evaluation of cartilage lesions and immunohistochemical analysis of cartilage to assess levels of inducible nitric oxide synthase (iNOS), matrix metalloprotease 13 (MMP-13) and protease activated receptor 2 (PAR-2) were done. (
  • 0.02) of osteoarthritis cartilage lesions. (
  • Treatment with BCD extract exerts a positive effect on the prevention of cartilage lesions induced by joint instability, and improves joint function. (
  • One study suggested that addition of a T2 mapping sequence to a routine MRI protocol at 3.0 T improved sensitivity in the detection of cartilage lesions in the knee joint, with only a slight reduction in specificity 5 . (
  • McCormick F, Harris JD, Abrams GD, Frank R, Gupta A, Hussey K, Wilson H, Bach B, Cole B. Trends in the surgical treatment of articular cartilage lesions in the United States: an analysis of a large private-payer database over a period of 8 years. (
  • Sensitivities were relatively low at all grades, particularly for grade 3 cartilage lesions. (
  • Because cartilage provides a protective gliding layer between the bones in a joint, when it is injured and lesions form, it can cause pits and abrasions in the bone. (
  • OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms. (
  • CONCLUSIONS The synovial fluid content of aggrecan is a potential tool in acute arthritis for distinguishing patients with a benign disease course from those who will develop a chronic joint disorder. (
  • The most common types of GAGs in cartilage are chondroitin sulfate and keratan sulfate, both of which are found in aggrecan. (
  • Disruption and excess of these signaling pathways cause genetic disorders in cartilage and skeletal tissues. (
  • The aim of this thesis is to create a better understanding of the etiology and pathophysiology of cartilage and bone development in patients with mucopolysaccharidosis and mucolipidosis, the clinical course and therapeutic challenges of skeletal disease in these disorders. (
  • Although the result is deformed or underdeveloped bones, many of these skeletal abnormalities are due to disorders of the cartilage. (
  • Chondrodysplasia is a general term for hereditary cartilage disorders that lead to skeletal malformations. (
  • A tendency to underestimate cartilage disorders on MR images was not noticed. (
  • Therefore, a reliable non-invasive visualization of cartilage disorders becomes important and may be an additional support in the decision, which therapeutic options should be suggested. (
  • This simplification mostly does not correspond to surgeons' demands of an exact staging of cartilage disorders. (
  • In addition to treating trauma to the musculoskeletal system, these doctors also deal with sports injuries, degenerative diseases, infections, tumors and congenital disorders. (
  • Some disorders are hereditary, involving production and structure of the cartilage. (
  • How will I know if I have cartilage disorders? (
  • Is there one best test to diagnose cartilage disorders? (
  • What is the definition or description of: Cartilage disorders? (
  • How did our ancestors on the prairie treat cartilage disorders? (
  • Are there official recommendations for treating cartilage disorders? (
  • There are of advances in treating cartilage disorders , some already been used (medications, special exercise , agua ) cartilage grafts , from the person himself or from donors. (
  • Maybe I worry too much, but I want to know how cartilage disorders will affect my child's overall health. (
  • Causes of cartilage problems include tears and injuries, such as sports injuries , genetic factors other disorders, such as some types of arthritis .So you see some stuff you help with and some you have no control at. (
  • provides long list of bone & cartilage disorders with links from each one for further information. (
  • Fractures, bone tumours, periodontal diseases, and degenerative cartilage disorders disrupt daily activities of people. (
  • Cartilage macromolecules in knee synovial fluid. (
  • The disease is accompanied by a reduction of synovial (joint) fluid, pain and restricted mobility. (
  • If cartilage does not properly calcify, it thickens and prevents synovial fluid from reaching cartilage cells beneath it. (
  • cartilage absorbs supplements mainly from the synovial fluid. (
  • Lubricin, a glycoprotein abundant in cartilage and synovial fluid, plays a major role in bio-lubrication and wear protection of cartilage. (
  • Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a variable number of glycosaminoglycan chains are attached. (
  • Proteoglycans of articular cartilage: changes in aging and in joint disease. (
  • Osteonecrosis is a disease that decreases blood circulation to bones causing them to weaken and eventually die. (
  • Skeletal abnormalities are common in MPS and ML patients and originate from intralysosomal storage in cells of the cartilage, bones and ligaments. (
  • The existing therapies for these diseases are unable to fully correct or prevent the abnormalities occurring in bones and cartilage. (
  • Osteomalacia is a disease involving softening of the bones. (
  • Your cartilage to bone transitions in health and disease bones: You might not transitions think of them much until something starts to go wrong. (
  • Healthy cartilage helps you move by allowing your bones to glide over each other. (
  • Cartilage serves several functions, including providing a framework upon which bone deposition can begin and supplying smooth surfaces for the movement of articulating bones. (
  • Articular cartilage is responsible for the almost friction-free movement of our bones against one another. (
  • The nasal cartilages associate with other cartilage structures of the nose or with bones of the facial skeleton. (
  • The septal nasal cartilage fits in a place between the perpendicular plate of the ethmoid and vomer bones while also being covered by an internal mucous membrane. (
  • The superior portion of the septal nasal cartilage attaches to the nasal bones, while the inferior portion attaches to the alar cartilages via fibrous tissues. (
  • The lateral nasal cartilage lies inferiorly to the nasal bones while sitting superiorly to the major alar cartilage, separated by a narrow fissure. (
  • A skeletal disease of the elderly with chronic inflammation of bones, causing long bones to thicken and soften. (
  • A fragment of bone or cartilage becoming trapped between the bones. (
  • Their research, published Wednesday in the online edition of the British science journal Nature, could help people with skeletal dysplasia, a group of rare diseases that affect skeletal growth through abnormalities in bone and cartilage, particularly types known as thanatophoric dysplasia and achondroplasia. (
  • The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. (
  • To enable development of new therapies it is crucial to understand the processes involved in abnormal cartilage and bone development as observed in MPS and ML and relate them to normal skeletal development. (
  • In these years and due to limitations in methodology, the studies focused mainly on tissues of high PG content, that is, cartilage, aorta, and skin. (
  • Relapsing polychondritis is an autoimmune disease in which the body's immune system begins to attack and destroy the cartilage tissues in the body. (
  • Osteoarthritis (OA) is a degenerative disease involving chondrocytes, cartilage and other joint tissues, and has a number of underlying causes, including both biochemical and mechanical factors. (
  • Damage to any of these tissues or structures can come from chronic orthopedic diseases or from an injury. (
  • The lateral nasal cartilage and major alar cartilage curl up upon interaction with one another, forming a tight connection through fibrous tissues. (
  • Superiorly, the major alar cartilages are connected to the lateral nasal cartilage via fibrous tissues. (
  • Osteoarthritis: Osteoarthritis is a disease of the whole joint, however, one of the most affected tissues is the articular cartilage. (
  • It begins usually in the fourth or fifth decade and is marked by recurrent periods of inflammation of the cartilage of various tissues of the body, lasting several weeks to months. (
  • Small cell lung cancer is a disease in which the cells of the lung tissues grow uncontrollably and form tumors. (
  • Osteoarthritis and rheumatoid arthritis are common cartilage and joint diseases that globally affect more than 200 million and 20 million people, respectively. (
  • Eventually, at the end stage of arthritis, the articular cartilage wears away completely and bone on bone contact occurs. (
  • Orthopedists are surgeons who address bone and joint diseases and injuries, such as arthritis, osteoarthritis, and body trauma. (
  • Degenerative joint diseases (e.g. rheumatoid arthritis or osteoarthritis) represent a major cause of disability and early retirements in the industrialised countries. (
  • However, it is generally accepted that once articular cartilage is injured, its ability to regenerate is limited and that injury progresses to arthritis with time . (
  • Disease, injury, and worn cartilage can all lead to arthritis. (
  • The prognosis for tarsal or hock osteochondrosis is more guarded because most dogs with this form of the disease already have significant arthritis. (
  • The initial manifestation is local, usually partial necrosis but the disease has the potential to progress to complete destruction of the femoral head with development of end-stage hip arthritis, and then requires joint replacement. (
  • This also justifies the non-coding RNAs' contribution in various cartilage-dependent pathological conditions such as arthritis, and so on. (
  • cartilage is called arthritis. (
  • In arthritis the cartilage is often worn away and not replaced. (
  • Rheumatoid arthritis is an autoimmune disease and also can affect cartilage. (
  • management of arthritis can include medication, physical or occupational therapy, patient education, weight loss, The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the US Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (
  • Your Name ) thought you would like to see this page from the Annals of the Rheumatic Diseases web site. (
  • Cartilage comprises a firm extracellular matrix synthesized by large, ovoid cells (chondrocytes) located in holes called lacunae. (
  • Because compositional magnetic resonance imaging (MRI) techniques enable detection of biochemical and microstructural changes in the cartilage extracellular matrix before gross morphological changes occur, they may be useful as outcome measures for clinical trials focusing on early and potentially reversible disease stages 1 . (
  • In both diseases, inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) stimulate the production of matrix metalloproteinases (MMPs), enzymes that can degrade all components of the extracellular matrix. (
  • The articular cartilage function is dependent on the molecular composition of the extracellular matrix (ECM). (
  • Cartilage growth thus refers to the matrix deposition, but can also refer to both the growth and remodeling of the extracellular matrix. (
  • The artificial cartilage that we engineer is fully biological with a structure akin to real cartilage. (
  • Biological engineering techniques are being developed to generate new cartilage, using a cellular "scaffolding" material and cultured cells to grow artificial cartilage. (
  • Cartilage regeneration is a procedure that attempts to restore damaged cartilage by harnessing the body's cells to regrow or replace lost cartilage. (
  • Much research has examined cartilage regeneration utilizing stem cells. (
  • Transplant of lab-grown cartilage is a first in joint-healing studies, says senior author Kyriacos Athanasiou, UCI Distinguished Professor of biomedical engineering. (
  • Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: the ECHODIAH cohort. (
  • A longitudinal study showed that lower baseline T1Gd values using dGEMRIC in medial and lateral femoral cartilage were associated with a higher grade of joint space narrowing after 11 years, and also with development of osteophytes 13 . (
  • The loose bone and cartilage might remain in place, or they can move into the joint area, which causes the joint to become unsteady. (
  • The rest of the joint may be normal or there may be additional cartilage damage, including OCD or severe full-thickness cartilage loss. (
  • 7Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan. (
  • Alternatively, repetitive micro-trauma and excessive loading of one joint or one part of the joint in particular can cause cartilage damage. (
  • In order to diagnose a cartilage problem a sports physician or physiotherapist would take a detailed subjective history first followed by a thorough clinical examination of the joint involved. (
  • The locking is often due to a loose fragment of cartilage being wedged into the joint space. (
  • This is the least invasive form of surgery, and involves removing any unstable parts of cartilage and also cleaning out the joint with a special solution. (
  • This informative article briefly testimonials the books explaining a catabolic function for NO in chondrocytes and cartilage, and summarizes existing research that may recommend alternative jobs for NO in the joint. (
  • In this study, we describe the effect of UP1306, a composition containing a proprietary blend of two standardized extracts from the heartwood of Acacia catechu and the root bark of Morus alba, in maintaining joint structural integrity and alleviating OA associated symptoms in monosodium-iodoacetate (MIA)-induced rat OA disease model. (
  • Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. (
  • The next step, Hu said, is to put the lab-grown cartilage into a load-bearing joint, to see if it remains durable under stress. (
  • The abnormally thickened cartilage is unable to receive a normal supply of nutrients from the joint fluid. (
  • It is a form of osteochondrosis that occurs when a weakened layer of cartilage becomes elevated because of joint fluid between it and surrounding cartilage and bone. (
  • These pieces not only interfere with movement, they can become wedged inside the joint, further eroding cartilage and causing severe pain. (
  • Conservative treatment for mild cases may include, a 6-8 week period of confinement, reduction of weight to reduce stress on the joint, non‑steroidal anti‑inflammatory medications to reduce pain and inflammation, nutraceuticals (dietary supplements that purport to have health benefits but are not regulated as drugs) such as chondroitin sulfate and glucosamine are often recommended to decrease inflammation, promote the development of new cartilage, strengthen existing cartilage. (
  • There is a surgical treatment for OCD that involves opening up the affected joint to expose the lesion, removing or reshaping the abnormal cartilage, and exposing blood vessels. (
  • Due to the great stress on the patellofemoral joint during resisted knee extension, the articular cartilage of the patella is among the thickest in the human body. (
  • Over the last years, surgeons and scientists have elaborated a series of cartilage repair procedures that help to postpone the need for joint replacement. (
  • Osteoarthritis is a disease of joint cartilage. (
  • The lower limbs, being weight-bearing, are usually affected more often by this joint disease than the upper limbs. (
  • The scientists tried to turn the stem cells into cartilage, but confirmed that they could not make normal cartilage cells. (
  • In experiments using mice, however, the scientists found that adding statins, widely used to treat people with high cholesterol levels, led to the formation of normal cartilage cells, and that transgenic mice given statins grew in height and weight. (
  • It has been suggested that T1rho imaging may be more sensitive than T2 mapping for differentiating between normal cartilage and early stage OA 9 . (
  • BACKGROUND Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia with severe growth failure and impaired immunity. (
  • Cartilage-hair hypoplasia (CHH) is a homogeneous autosomal recessive metaphyseal chondrodysplasia characterised by severe short limbed short stature (adult height 110-135 cm) and hypoplastic hair. (
  • Cartilage-hair hypoplasia (CHH) is a rare chondrodysplasia with short stature, hair hypoplasia, variable degree of immunodeficiency and increased risk of malignancy. (
  • Cartilage-hair hypoplasia is caused by mutations in the RMRP gene and is inherited in an autosomal recessive fashion. (
  • Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia. (
  • The recessively inherited developmental disorder, cartilage-hair hypoplasia (CHH) is highly pleiotropic with manifestations including short stature, defective cellular immunity, and predisposition to several cancers. (
  • Cartilage metabolism--a response. (
  • However, the staining for all of these GAG metabolism enzymes were hardly observed in the deep zones of KBD cartilage, suggesting that significant cell death and necrosis had occurred in this region. (
  • Conclusions Our results indicate that alterations of enzymes involved in articular cartilage CS GAG metabolism on PGs in the articular cartilage play an important role in the onset and pathogenesis of KBD in adolescent children. (
  • In patients with osteoarthritis, a detailed assessment of degenerative cartilage disease is important to recommend adequate treatment. (
  • Increased mortality was associated with severe short stature at birth, Hirschsprung disease, pneumonia, autoimmunity and symptoms of combined immunodeficiency. (
  • The clinical symptoms of the disease occur depending on the localization of education. (
  • Cogan's syndrome is defined as a chronic inflammatory disease of unknown origin, an autoimmune disease, characterized by bilateral sensorineural hearing loss, vestibular symptoms, inflammatory ocular manifestations with variable risk of developing into a systemic disease. (
  • While children may still be growing, the evidence of symptoms indicates that cartilage cells, or chondrocytes, have already become pathological. (
  • This table lists symptoms that people with this disease may have. (
  • For most diseases, symptoms will vary from person to person. (
  • People with the same disease may not have all the symptoms listed. (
  • Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. (
  • Do you have more information about symptoms of this disease? (
  • Monarch's tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. (
  • This rare disease is also called relapsing polychondrosis, and symptoms can range from mild to severe. (
  • Corticosteroid medications are administered to moderate the symptoms of the disease, but the effects on the cartilage cannot be reversed. (
  • In contrast, in patients with endstage knee OA who had total knee arthroplasty, T2* values of knee articular cartilage decreased with increasing histologic cartilage degeneration 8 . (
  • T1rho and dGEMRIC mapping seemed to be more sensitive to early stages of cartilage degeneration than quantitative T2 10 . (
  • The role of T2 mapping in different stages of cartilage degeneration is still not well defined. (
  • Much more common are problems like osteoarthritis - a degeneration of the cartilage due to wear and tear, obesity , etc. (
  • It is characterized by inflammation and degeneration of cartilage and can result in deformities such as floppy ear and saddle nose. (
  • Elastic cartilage is found in several parts of the ear and in the epiglottis, and is the most pliable type of cartilage. (
  • In elastic cartilage, elastic fibers in the matrix increase resilience, as in cartilages supporting the Eustachian tube, mammalian external ear, and parts of the larynx. (
  • The compression of the articular cartilage or flexion of the elastic cartilage generates fluid flow, which assists the diffusion of nutrients to the chondrocytes. (
  • We wish to apply mechanical stimulation of chondrocytes and cartilage by application of pulsed low-intensity ultrasound (PLIUS) so as to increase expression of matrix-related mRNA and corresponding matrix production, the goal being to upregulate repair processes in an animal model of osteoarthritis (OA). (
  • Such variability includes varying degrees and distribution of cartilage damage on the medial coronoid process (MCP) or humeral trochlea (HT) with some dogs having arthroscopically normal or near normal articular cartilage in the medial compartment while other dogs have complete loss of articular cartilage throughout the medial compartment ( 1 , 2 ). (
  • While the damage may be small, cartilage will wear faster with weak spots. (
  • of Chronic Lyme Sufferers do get permanent damage in the cartilage of their ears. (
  • My pain is constant, I believe that the spirochetes have done permanent damage to the cartilage in my ears. (
  • An acute traumatic episode, such as a twisting or heavy impact injury of the knee can cause cartilage damage. (
  • MRI scans are the best form of scan as they will show both the extent of the cartilage damage and also the involvement of the underlying bone surfaces. (
  • Such stimuli lead to cell microenvironment damage, non-resolving inflammation and disease. (
  • Current OA management is inadequate due to the lack of nominal therapies proven to be effective in hampering disease progression where symptomatic therapy focused intervention masks the primary etiology leading to irreversible structural damage. (
  • FAI is a common cause of hip pain and can lead to acetabular cartilage damage and osteoarthritis. (
  • For other patients, however, surgery is contraindicated because significant cartilage damage has already occurred. (
  • In this paper, we describe the pairing of T2* mapping data (an investigational, objective MRI sequence) and a spatial proportional odds model for surgically obtained ordinal outcomes (Beck's scale of cartilage damage). (
  • Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo. (
  • Therefore, cartilage damage is difficult to heal. (
  • Further, the degree of the changes in the cell morphology correlated well with the amount of change in the gene expressions of the cells, which could help explain why the severity is so variable for the two diseases. (
  • Our findings suggest we can recapitulate the phenotype severity of the disease and explore drug targets. (
  • The severity of a cartilage injury depends on the depth of the lesion. (
  • In clinical practice, a detailed assessment of disease severity includes an exact grading of the cartilage. (
  • The treatment of Legg-Calve-Perthes disease depends on its severity. (
  • No correlation between the severity or location of the cartilage changes and the operative effect was found. (
  • Non-traumatic femoral head necrosis (osteonecrosis) in adults is an acquired ischemic disease of the femoral head characterized by a multifactorial etiology. (
  • An acquired disease of unknown etiology, chronic course, and tendency to recur. (
  • Dogs tentatively diagnosed with medial coronoid disease had evaluation of their affected elbows using radiography, morphological MRI sequences, and dGEMRIC MRI evaluation prior to arthroscopy. (
  • Even if the practical benefit of MRI in pretreatment diagnostics is unequivocal, a diagnostic arthroscopy is of outstanding value when a grading of the cartilage is crucial for a definitive decision regarding therapeutic options in patients with osteoarthritis. (
  • Techniques comprise relaxometry measurements (T2, T2* and T1rho mapping) including T2* mapping with ultrashort echo-time imaging, sodium imaging, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), magnetization transfer contrast and glycosaminoglycan (GAG)-specific chemical exchange saturation transfer (gagCEST), diffusion-weighted imaging, and diffusion tensor imaging. (
  • Learn about how CIRM-funded stem cell research could generate treatments for many chronic diseases and injuries. (
  • Bone diseases are generally cartilage to bone transitions in health and disease present at birth or the result of nutritional deficiencies or injuries. (
  • Orthopedic conditions are injuries and diseases that affect the musculoskeletal system. (
  • The present invention discloses a method and a pharmaceutical composition comprising mesenchymal stem cells, platelets, activating factors and scaffolding materials for the treatment, prevention, or alleviation of bone diseases, bone injuries or hair loss, and a method and a pharmaceutical composition further comprising dexamethasone for the treatment, prevention, or alleviation of cartilage diseases or injuries. (
  • Certain cartilage injuries can be rebuilt with cartilage transplants or a microfracture technique. (
  • Loss of cartilage in the respiratory tract can lead to respiratory obstruction. (
  • The disease also damages the synovium, the joint's lubricating mechanism. (
  • Therefore compositional MRI techniques have rarely been applied in clinical trials 2 , but they have been used with increasing frequency in OA research for "premorphologic" evaluation of cartilage. (
  • The matrix component of cartilage contains collagenous fibers, and/or elastin fibers, and cells called "chondrocytes. (
  • This procedure works by inducing degree of trauma to the bone which initiates a healing process and subsequently the cartilage defect is replaced by fibrocartilage. (
  • It is one aim to prove that besides classical methods of biochemistry, biophysical techniques are also useful to study cartilage structure and function. (
  • is a disease that affects cartilage formation. (
  • Relapsing polychondritis is a rare inflammatory disease that primarily affects cartilage. (
  • Does Prior Cartilage Restoration Impact Outcomes Following Knee Arthroplasty? (
  • Projects include creating new cartilage from donor stem cells as well as developing a drug to drive a person's own stem cells to do a better job of repair. (
  • Researchers at the California Institute for Biomedical Research (CALIBR) have been awarded $8.447 million to test KA34, a drug that, in preclinical tests, recruits stem cells to create new cartilage in areas damaged by osteoarthritis. (
  • CIRM funded the research that developed this technology and now this Phase 1 trial will test this stem cell directed treatment in people with osteoarthritis of the knee, hopefully slowing down or even halting the progression of the disease. (
  • In particular, it focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies and approaches involving stem cells that have been used in cartilage repair and clinical studies. (
  • When it is healthy, cartilage surfaces glide smoothly over each other. (
  • C-type natriuretic peptide is currently the most promising therapy for achondroplasia and related autosomal genetic diseases that manifest severe dwarfism. (
  • Therefore, traumatic articular cartilage injury and early osteoarthritis (OA) cause pain, accelerate arthrosis, and cause severe dysfunction. (
  • Since i got my injury (multi disc disease and cut in shoulder cartilage)due to heavy lifting, im facing severe depression as i can no longer go to gym? (
  • OCD is generally though to be a hereditary disease, however there is growing evidence that onset of the condition can in some cases be related to diet or injury. (