Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.
Transport proteins that carry specific substances in the blood or across cell membranes.
The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.
An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC
An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.
This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to generate malonyl-(acyl-carrier protein), which is an elongation substrate in FATTY ACIDS biosynthesis. It is an essential enzyme in the biosynthesis of FATTY ACIDS in all BACTERIA.
An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.
A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Proteins found in any species of bacterium.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. It has a preference for acyl derivatives with carbon chain length from 4 to 16.
Identification of genetic carriers for a given trait.
The rate dynamics in chemical or physical systems.
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The addition of an organic acid radical into a molecule.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred to this activity or to the activity of ACETYL-COA C-ACYLTRANSFERASE.
Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
An individual having different alleles at one or more loci regarding a specific character.
A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Proteins obtained from ESCHERICHIA COLI.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).
A class of enzymes that form a thioester bond to UBIQUITIN with the assistance of UBIQUITIN-ACTIVATING ENZYMES. They transfer ubiquitin to the LYSINE of a substrate protein with the assistance of UBIQUITIN-PROTEIN LIGASES.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
A symporter protein that couples the transport of FOLIC ACID with HYDROGEN IONS. The transporter functions most effectively under acidic conditions.
Proteins prepared by recombinant DNA technology.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
A family of organic anion transporters that specifically transport DICARBOXYLIC ACIDS such as alpha-ketoglutaric acid across cellular membranes.
Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some ANTINEOPLASTIC AGENTS and ANTI-OBESITY AGENTS and of some ANTI-INFECTIVE AGENTS which interfere with CELL WALL and CELL MEMBRANE formation.
An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.
Proteins that bind to and are involved in the metabolism of phosphate ions.
A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
The sum of the weight of all the atoms in a molecule.
Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Compounds that contain a 1-dimethylaminonaphthalene-5-sulfonyl group.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The functional hereditary units of BACTERIA.
A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)
Compounds containing the -SH radical.
The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The enzymatic synthesis of PEPTIDES without an RNA template by processes that do not use the ribosomal apparatus (RIBOSOMES).
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.
An enzyme that transfers acyl groups from acyl-CoA to glycerol-3-phosphate to form monoglyceride phosphates. It acts only with CoA derivatives of fatty acids of chain length above C-10. Also forms diglyceride phosphates. EC
The facilitation of biochemical reactions with the aid of naturally occurring catalysts such as ENZYMES.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A plant genus of the family Cruciferae. It contains many species and cultivars used as food including cabbage, cauliflower, broccoli, Brussel sprouts, kale, collard greens, MUSTARD PLANT; (B. alba, B. junica, and B. nigra), turnips (BRASSICA NAPUS) and rapeseed (BRASSICA RAPA).
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
A plant genus of the family ARALIACEAE. Members contain hederin (olean-12-ene) type TRITERPENES.
A family of proteins that are structurally-related to Ubiquitin. Ubiquitins and ubiquitin-like proteins participate in diverse cellular functions, such as protein degradation and HEAT-SHOCK RESPONSE, by conjugation to other proteins.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Incorporation of biotinyl groups into molecules.
Common name for Ricinus communis, a species in the family EUPHORBIACEAE. It is the source of CASTOR OIL.
Includes ortho-, meta-, and para-nitrophenylgalactosides.
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.
Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.
Any salt or ester of glycerophosphoric acid.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
A genus of VIBRIONACEAE, made up of short, slightly curved, motile, gram-negative rods. Various species produce cholera and other gastrointestinal disorders as well as abortion in sheep and cattle.
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
Polysaccharides found in bacteria and in capsules thereof.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
A LIPOIC ACID-containing protein that plays the pivotal role in the transfer of methylamine groups and reducing equivalents between the three enzymatic components of the glycine decarboxylase complex.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A species of STIGMATELLA usually isolated from rotting wood. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
A species of gram-negative bacteria in the genus NEORICKETTSIA, family ANAPLASMATACEAE, causing Sennetsu fever and found in the FAR EAST and SOUTHEAST ASIA.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
The removal of a carboxyl group, usually in the form of carbon dioxide, from a chemical compound.
Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.
Amino acid transporter systems capable of transporting acidic amino acids (AMINO ACIDS, ACIDIC).
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.
A cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
The protein components of enzyme complexes (HOLOENZYMES). An apoenzyme is the holoenzyme minus any cofactors (ENZYME COFACTORS) or prosthetic groups required for the enzymatic function.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Intracellular proteins that reversibly bind hydrophobic ligands including: saturated and unsaturated FATTY ACIDS; EICOSANOIDS; and RETINOIDS. They are considered a highly conserved and ubiquitously expressed family of proteins that may play a role in the metabolism of LIPIDS.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.
Those genes found in an organism which are necessary for its viability and normal function.
A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.
An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Self-replicating cytoplasmic organelles of plant and algal cells that contain pigments and may synthesize and accumulate various substances. PLASTID GENOMES are used in phylogenetic studies.
A red yeast-like mitosporic fungal genus generally regarded as nonpathogenic. It is cultured from numerous sources in human patients.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency.
Proteins involved in the transport of NUCLEOTIDES across cellular membranes.
The relationships of groups of organisms as reflected by their genetic makeup.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Plant cell inclusion bodies that contain the photosynthetic pigment CHLOROPHYLL, which is associated with the membrane of THYLAKOIDS. Chloroplasts occur in cells of leaves and young stems of plants. They are also found in some forms of PHYTOPLANKTON such as HAPTOPHYTA; DINOFLAGELLATES; DIATOMS; and CRYPTOPHYTA.
A carboxy-lyase that catalyzes the decarboxylation of (S)-2-Methyl-3-oxopropanoyl-CoA to propanoyl-CoA. In microorganisms the reaction can be coupled to the vectorial transport of SODIUM ions across the cytoplasmic membrane.
Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis.
Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. (1/44195)

BACKGROUND: The adaptor protein Gads is a Grb2-related protein originally identified on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein Shc. Gads protein expression is restricted to hematopoietic tissues and cell lines. Gads contains a Src homology 2 (SH2) domain, which has previously been shown to have a similar binding specificity to that of Grb2. Gads also possesses two SH3 domains, but these have a distinct binding specificity to those of Grb2, as Gads does not bind to known Grb2 SH3 domain targets. Here, we investigated whether Gads is involved in T-cell signaling. RESULTS: We found that Gads is highly expressed in T cells and that the SLP-76 adaptor protein is a major Gads-associated protein in vivo. The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76. Gads also coimmunoprecipitated the tyrosine-phosphorylated form of the linker for activated T cells (LAT) adaptor protein following cross-linking of the T-cell receptor; this interaction was mediated by the Gads SH2 domain. Overexpression of Gads and SLP-76 resulted in a synergistic augmentation of T-cell signaling, as measured by activation of nuclear factor of activated T cells (NFAT), and this cooperation required a functional Gads SH2 domain. CONCLUSIONS: These results demonstrate that Gads plays an important role in T-cell signaling via its association with SLP-76 and LAT. Gads may promote cross-talk between the LAT and SLP-76 signaling complexes, thereby coupling membrane-proximal events to downstream signaling pathways.  (+info)

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. (2/44195)

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.  (+info)

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. (3/44195)

Previously we demonstrated the expression of the long form of the leptin receptor in rodent pancreatic beta-cells and an inhibition of insulin secretion by leptin via activation of ATP-sensitive potassium channels. Here we examine pancreatic islets isolated from pancreata of human donors for their responses to leptin. The presence of leptin receptors on islet beta-cells was demonstrated by double fluorescence confocal microscopy after binding of a fluorescent derivative of human leptin (Cy3-leptin). Leptin (6.25 nM) suppressed insulin secretion of normal islets by 20% at 5.6 mM glucose. Intracellular calcium responses to 16.7 mM glucose were rapidly reduced by leptin. Proinsulin messenger ribonucleic acid expression in islets was inhibited by leptin at 11.1 mM, but not at 5.6 mM glucose. Leptin also reduced proinsulin messenger ribonucleic acid levels that were increased in islets by treatment with 10 nM glucagon-like peptide-1 in the presence of either 5.6 or 11.1 mM glucose. These findings demonstrate direct suppressive effects of leptin on insulin-producing beta-cells in human islets at the levels of both stimulus-secretion coupling and gene expression. The findings also further indicate the existence of an adipoinsular axis in humans in which insulin stimulates leptin production in adipocytes and leptin inhibits the production of insulin in beta-cells. We suggest that dysregulation of the adipoinsular axis in obese individuals due to defective leptin reception by beta-cells may result in chronic hyperinsulinemia and may contribute to the pathogenesis of adipogenic diabetes.  (+info)

Evidence for F-actin-dependent and -independent mechanisms involved in assembly and stability of the medial actomyosin ring in fission yeast. (4/44195)

Cell division in a number of eukaryotes, including the fission yeast Schizosaccharomyces pombe, is achieved through a medially placed actomyosin-based contractile ring. Although several components of the actomyosin ring have been identified, the mechanisms regulating ring assembly are still not understood. Here, we show by biochemical and mutational studies that the S.pombe actomyosin ring component Cdc4p is a light chain associated with Myo2p, a myosin II heavy chain. Localization of Myo2p to the medial ring depended on Cdc4p function, whereas localization of Cdc4p at the division site was independent of Myo2p. Interestingly, the actin-binding and motor domains of Myo2p are not required for its accumulation at the division site although the motor activity of Myo2p is essential for assembly of a normal actomyosin ring. The initial assembly of Myo2p and Cdc4p at the division site requires a functional F-actin cytoskeleton. Once established, however, F-actin is not required for the maintenance of Cdc4p and Myo2p medial rings, suggesting that the attachment of Cdc4p and Myo2p to the division site involves proteins other than actin itself.  (+info)

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. (5/44195)

We have identified Socs1 as a downstream component of the Kit receptor tyrosine kinase signalling pathway. We show that the expression of Socs1 mRNA is rapidly increased in primary bone marrow-derived mast cells following exposure to Steel factor, and Socs1 inducibly binds to the Kit receptor tyrosine kinase via its Src homology 2 (SH2) domain. Previous studies have shown that Socs1 suppresses cytokine-mediated differentiation in M1 cells inhibiting Janus family kinases. In contrast, constitutive expression of Socs1 suppresses the mitogenic potential of Kit while maintaining Steel factor-dependent cell survival signals. Unlike Janus kinases, Socs1 does not inhibit the catalytic activity of the Kit tyrosine kinase. In order to define the mechanism by which Socs1-mediated suppression of Kit-dependent mitogenesis occurs, we demonstrate that Socs1 binds to the signalling proteins Grb-2 and the Rho-family guanine nucleotide exchange factors Vav. We show that Grb2 binds Socs1 via its SH3 domains to putative diproline determinants located in the N-terminus of Socs1, and Socs1 binds to the N-terminal regulatory region of Vav. These data suggest that Socs1 is an inducible switch which modulates proliferative signals in favour of cell survival signals and functions as an adaptor protein in receptor tyrosine kinase signalling pathways.  (+info)

The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. (6/44195)

The first appearance of G1 during Drosophila embryogenesis, at cell cycle 17, is accompanied by the down-regulation of E2F-dependent transcription. Mutant alleles of rbf were generated and analyzed to determine the role of RBF in this process. Embryos lacking both maternal and zygotic RBF products show constitutive expression of PCNA and RNR2, two E2F-regulated genes, indicating that RBF is required for their transcriptional repression. Despite the ubiquitous expression of E2F target genes, most epidermal cells enter G1 normally. Rather than pausing in G1 until the appropriate time for cell cycle progression, many of these cells enter an ectopic S-phase. These results indicate that the repression of E2F target genes by RBF is necessary for the maintenance but not the initiation of a G1 phase. The phenotype of RBF-deficient embryos suggests that rbf has a function that is complementary to the roles of dacapo and fizzy-related in the introduction of G1 during Drosophila embryogenesis.  (+info)

The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. (7/44195)

The cellular protein p32 was isolated originally as a protein tightly associated with the essential splicing factor ASF/SF2 during its purification from HeLa cells. ASF/SF2 is a member of the SR family of splicing factors, which stimulate constitutive splicing and regulate alternative RNA splicing in a positive or negative fashion, depending on where on the pre-mRNA they bind. Here we present evidence that p32 interacts with ASF/SF2 and SRp30c, another member of the SR protein family. We further show that p32 inhibits ASF/SF2 function as both a splicing enhancer and splicing repressor protein by preventing stable ASF/SF2 interaction with RNA, but p32 does not block SRp30c function. ASF/SF2 is highly phosphorylated in vivo, a modification required for stable RNA binding and protein-protein interaction during spliceosome formation, and this phosphorylation, either through HeLa nuclear extracts or through specific SR protein kinases, is inhibited by p32. Our results suggest that p32 functions as an ASF/SF2 inhibitory factor, regulating ASF/SF2 RNA binding and phosphorylation. These findings place p32 into a new group of proteins that control RNA splicing by sequestering an essential RNA splicing factor into an inhibitory complex.  (+info)

Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. (8/44195)

The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G0-G1-S progression by contributing to the phosphorylation and inactivation of the retinoblastoma gene product, pRB. Assembly of active cyclin D-CDK complexes in response to mitogenic signals is negatively regulated by INK4 family members. Here we show that although all four INK4 proteins associate with CDK4 and CDK6 in vitro, only p16(INK4a) can form stable, binary complexes with both CDK4 and CDK6 in proliferating cells. The other INK4 family members form stable complexes with CDK6 but associate only transiently with CDK4. Conversely, CDK4 stably associates with both p21(CIP1) and p27(KIP1) in cyclin-containing complexes, suggesting that CDK4 is in equilibrium between INK4 and p21(CIP1)- or p27(KIP1)-bound states. In agreement with this hypothesis, overexpression of p21(CIP1) in 293 cells, where CDK4 is bound to p16(INK4a), stimulates the formation of ternary cyclin D-CDK4-p21(CIP1) complexes. These data suggest that members of the p21 family of proteins promote the association of D-type cyclins with CDKs by counteracting the effects of INK4 molecules.  (+info)

cMyBP-C [cardiac (MyBP-C) myosin-binding protein-C)] is a sarcomeric protein involved both in thick filament structure and in the regulation of contractility. It is composed of eight IgI-like and three fibronectin-3-like domains (termed C0-C10). Mutations in the gene encoding cMyBP-C are a principal
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Myosin Binding Protein C, Slow Type (MYBPC1) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species ...
Compare WW domain binding protein 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Rabbit polyclonal WW domain binding protein 4 antibody validated for WB and tested in Human. Immunogen corresponding to synthetic peptide
In order to characterize expression of Homers in mouse brain and peripheral tissues we have developed a coupled reverse transcription (RT)-PCR/restriction digestion approach. This has allowed us to determine the molecular composition and relative levels of the constitutive expression of the Homer-1, -2 and -3 mRNAs across mouse tissues. We report here that mammalian brain constitutively expresses high levels of the Homer-1, -2 and -3 mRNAs. Expression of the Homer-1 mRNAs reaches 66% of the brain total Homer mRNAs expression, followed by Homer-3 mRNA (22%) and Homer-2 mRNAs (12%). Quantitative RT-PCR analysis and the Western blotting using pan-Homer antibody revealed that mouse heart, skeletal muscle and diaphragm constitutively express high levels of the Homer proteins and their mRNAs. We have shown that the molecular profile of expression of Homer-1, -2 and -3 mRNAs in muscle containing tissues resembles that obtained for mammalian brain.
Complete information for MYBPC3 gene (Protein Coding), Myosin Binding Protein C3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Mouse Monoclonal Anti-PGLYRP1/PGRP-S Antibody (188C424) [HRP]. Validated: WB, IHC, IHC-Fr. Tested Reactivity: Human, Mouse. 100% Guaranteed.
WBP11 antibody, N-term (WW domain binding protein 11) for IHC-P, IP, WB. Anti-WBP11 pAb (GTX46466) is tested in Human, Mouse samples. 100% Ab-Assurance.
Complete information for SH3BP5 gene (Protein Coding), SH3 Domain Binding Protein 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
SH3BP1 antibody, C-term (SH3-domain binding protein 1) for ICC/IF, IHC-P, WB. Anti-SH3BP1 pAb (GTX10103) is tested in Human samples. 100% Ab-Assurance.
Secretory Carrier Membrane Proteins (SCAMPs) are a group of tetraspanning integral membrane proteins evolutionarily conserved from insects to mammals and plants. Mammalian genomes contain five SCAMP genes SCAMP1-SCAMP5 that regulate membrane dynamics, most prominently membrane-depolarization and Ca2+-induced regulated secretion, a key mechanism for neuronal and neuroendocrine signaling. However, the biological role of SCAMPs has remained poorly understood primarily owing to the lack of appropriate model organisms and behavior assays. Here we generate Drosophila Scamp null mutants and show that they exhibit reduced lifespan and behavioral abnormalities including impaired climbing, deficiency in odor associated long-term memory, and a susceptibility to heat-induced seizures. Neuron-specific restoration of Drosophila Scamp rescues all Scamp behavioral phenotypes, indicating that the phenotypes are due to loss of neuronal Scamp. Remarkably, neuronal expression of human SCAMP genes rescues selected
Microsomal triglyceride transfer protein (MTP) is required for the assembly and cellular secretion of apolipoprotein B (apoB) -containing lipoproteins from the liver and intestine. The secretion pattern of apoB-containing lipoproteins is likely to influence the VLDL and LDL levels in plasma. By initial opportunistic screening for polymorphic sites in the regulatory region of the MTP gene by gene sequencing in 20 healthy male subjects, a common functional G/T polymorphism was detected 493 bp upstream from the transcriptional start point. There was differential binding of unique nuclear proteins at this site, as shown by electrophoretic mobility shift assay. The G variant seemed to bind two or three nuclear proteins that do not bind to the T variant. Expression studies with minimal promoter constructs linked to the chloramphenicol acetyltransferase reporter and transfected into HepG2 cells revealed marked enhancement of transcriptional activity with the T variant. The prevalence of the MTP promoter
Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA). Efficient phosphorylation requires that PKA be anchored close to its targets by A-kinase anchoring proteins (AKAPs). Cardiac Myosin Binding Protein-C (cMyBPC) and cardiac troponin I (cTNI) are hypertrophic cardiomyopathy (HCM)-causing sarcomeric proteins which regulate contractility in response to PKA phosphorylation. During a yeast 2-hybrid (Y2H) library screen using a trisphosphorylation mimic of the C1-C2 region of cMyBPC, we identified isoform 4 of myomegalin (MMGL) as an interactor of this N-terminal cMyBPC region. As MMGL has previously been shown to interact with phosphodiesterase 4D, we speculated that it may be a PKA-anchoring protein (AKAP). To investigate this possibility, we assessed the ability of MMGL isoform 4 to interact with PKA regulatory subunits R1A and R2A using Y2H-based direct protein-protein interaction assays. Additionally, to further
Heritable cardiomyopathy (HCM) is the leading cause of sudden cardiac arrest (SCA) in young people, affecting 1 in 500 individuals. HCM is chiefly caused by mutations in myofibrillar proteins of the cardiac sarcomere, and cardiac myosin binding protein-C (cMyBP-C, encoded by MYBPC3) is one of the most commonly affected. cMyBP-C, an accessory protein that binds tightly to myosin, has an important role in thick filament regulation. Mice with genetic ablation of MYBPC3 exhibit cardiac hypertrophy, reduced ejection fraction, and increased relaxation times in vivo. Experiments with explanted hearts from these mice exhibit greater susceptibility to arrhythmias compared to WT, suggesting derangement of Ca2+ handling. The molecular mechanisms underlying the progression of HCM are poorly understood, and are difficult to tease apart in constitutive knock out models due to potential compensatory changes that can mask important aspects of the disease phenotype. We used a tamoxifen-induced conditional MYBPC3 ...
Rationale: A stable 40 kD fragment is produced from cardiac myosin binding protein-C (cMyBP-C) when the heart is stressed, using a stimulus such as ischemia reperfusion injury. Elevated levels of the fragment can be detected in both the diseased mouse and human heart but its ability to interfere with normal cardiac function in the intact animal is unexplored. Objective: To understand the potential pathogenicity of the 40 kD fragment in vivo and to investigate the molecular pathways that could be targeted for potential therapeutic intervention. Methods and Results: We generated cardiac myocyte-specific transgenic mice (TG) using a Tet-Off inducible system to permit controlled expression of the 40 kD fragment in cardiomyocytes. When 40 kD protein expression is induced by crossing the responder animals with tetracycline transactivator (tTA) mice under conditions where substantial quantities approximating those observed in disease hearts are reached, the double TG (DTG) mice subsequently develop ...
The present invention relates to the use of fibroblast growth factor-binding protein (FGF-BP) polypeptides, and functional variants of these polypeptides, respectively, or of nucleic acids encoding th
TY - JOUR. T1 - Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C during Increased Pacing Frequency or β1-Adrenergic Stimulation. AU - Tong, Carl W.. AU - Wu, Xin. AU - Liu, Yang. AU - Rosas, Paola C.. AU - Sadayappan, Sakthivel. AU - Hudmon, Andy. AU - Muthuchamy, Mariappan. AU - Powers, Patricia A.. AU - Valdivia, Héctor H.. AU - Moss, Richard L.. PY - 2015/5/4. Y1 - 2015/5/4. N2 - Background-Mammalian hearts exhibit positive inotropic responses to β-adrenergic stimulation as a consequence of protein kinase A-mediated phosphorylation or as a result of increased beat frequency (the Bowditch effect). Several membrane and myofibrillar proteins are phosphorylated under these conditions, but the relative contributions of these to increased contractility are not known. Phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) by protein kinase A accelerates the kinetics of force development in permeabilized heart muscle, but its role in vivo is unknown. Such understanding is ...
Growth hormone-binding protein (GHBP) is a soluble carrier protein for growth hormone (GH). The function of GHBP is still unknown. Current research suggests that the protein is associated with regulation of the GH supply in the circulatory system as well as GH receptor function. In humans, GHBP is formed by post-translational modification after the complete transcription and translation of the growth hormone receptor (GHR) gene into the cell-surface receptor protein. The gene that codes for GHR (and inherently GHBP) is on Chromosome 5. A precursor messenger RNA (mRNA) from the complete gene first is transcribed and then spliced to encode the full receptor protein. This mature mRNA is composed of exons. Exons are peptide encoding regions of DNA genes that remain in the transcript after splicing and during the maturation of mRNA. The mRNA transcript encodes for a receptor protein that is made up of three distinct parts: an intracellular domain, a transmembrane domain, and an extracellular domain. ...
Myomegalin has been characterized as a protein with the properties of a scaffold or structural protein that is expressed at high levels in skeletal and cardiac tissue, suggesting an important function in muscle, and which interacts with a cAMP-specific phosphodiesterase [13]. However, the precise function and interactions of this protein, and its five isoforms, have been largely unknown. We here describe how the smallest MMGL isoform, isoform 4, binds to known and predicted PKA targets in the cardiac myocyte, including some sarcomeric proteins, viz. cMyBPC, cTNI, ENO1, ENO3, CARP and COMMD4 (Tables 1 and 2). Moreover, we show that MMGL isoform 4 interacts with two regulatory subunits of PKA (Figure 3). Together these results describe MMGL isoform 4 as a novel sarcomeric AKAP, which, like mAKAP [14], is involved in assembling a PKA/PDE cAMP signalling module.. In addition to interacting with both types of regulatory subunits, viz. RI and RII, which qualifies MMGL isoform 4 as a dual-specific AKAP ...
Browsing Doctoral Degrees (Molecular Biology and Human Genetics) by Title An investigation of myosin binding protein C mutations in South Africa and a search for ligands binding to myosin binding protein C ...
Cardiac myosin binding protein-C (cMyBPC) is a modular protein consisting of 11 domains whose precise function and sarcomeric arrangement are incompletely understood. Identification of hypertrophic cardiomyopathy (HCM)--causing missense mutations in cMyBPC has highlighted the significance of certain domains. Of particular interest is domain C5, an immunoglobulin-like domain with a cardiac-specific insert, which is of unknown function yet is the site of two HCM-causing missense mutations. To identify interactors with this region, a human cardiac cDNA library was screened in a yeast two-hybrid (Y2H) assay using the C5 sequence as bait. Screening |7x10(6) clones surprisingly revealed that domain C5 preferentially bound to clones encoding C-terminal fragments of cMyBPC; the interacting region was narrowed to domain C8 by deletion mapping. A surface plasmon resonance assay using purified recombinant cMyBPC domains was used to measure the affinity of C5 and C8 in vitro (K(a)=1x10(5) mol/L(-1)). This affinity
Mutations in the cardiac myosin binding protein C gene (MYBPC3) are common causes of hypertrophic cardiomyopathy (HCM) in humans. Even though the MYBPC3 E258K missense mutation is among the most prevalent HCM-causing mutations, the mechanism through which it causes disease remains unclear. We developed a novel neonatal murine 3D engineered cardiac tissue (ECT) model and previously presented data showing that Mybpc3 ablation (Mybpc3−/−) accelerates the kinetics of contraction and relaxation in the absence of hypertrophic remodeling in ECT. Furthermore, we showed that expression of wild type human MYBPC3 in Mybpc3−/− ECT (MYBPC3WT) restores contractile function. We hypothesized that adenoviral mediated expression of human E258K MYBPC3 in Mybpc3−/− ECT (MYBPC3E258K) would accelerate contractile kinetics and blunt the effect of dobutamine by abolishing phosphorylation-regulated inhibitory interactions between the C2-M-domain region of cMyBPC and myosin S2. The contractile characteristics ...
Copines make up a multigene family of calcium-dependent, phospholipid-binding proteins. Copine proteins consists of two C2 domains at the N terminus followed by an A domain similar to the von Willebrand-Integrin A domain. Mutant studies of copines suggest that copines may be involved in signaling pathways and may play a significant role in cell differentiation, programmed cell death, and cell development. Copines need to be studied further to have a clear understanding of the function they play in organismal life processes. We are studying copine protein function in the model organism protozoan Dictyostelium discoideum. Previous research showed that the copine A (cpnA-) knockout strain of Dictyostelium exhibited normal growth rates, a slight cytokinesis defect, a developmental defect, and a defect in contractile vacuole function. Furthermore, real-time reverse transcription-PCR data suggested that all of the copine genes except cpnF may be important regulators of Dictyostelium development. To ...
We have reported studies characterizing small-molecule inhibitors that selectively inhibit PLTP activity and concomitantly reduce apoB secretion. In the present study, we identified small molecules that inhibit both PLTP and MTP activities, which are known to regulate apoB secretion. This is the first report to identify dual inhibitors for PLTP and MTP activities. The discovery was not expected based on the lack of homology of PLTP and MTP at protein sequence levels. Although CETP and PLTP have 40% homology and belong to the family of lipid transfer/lipopolysaccharide-binding proteins (Tollefson et al., 1988; Day et al., 1994), none of these compounds inhibit CETP activity (Luo et al., 2010). MTP and apoB belong to the vitellogenin family of lipid transfer proteins. Read et al. (2000) predicted the three-dimensional structure of the C-terminal lipid binding cavity of MTP based on the crystal structure of lipoviellin. The lipid cavity in MTP bears a resemblance to the lipid binding domain of ...
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability ...
Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the antioxidant thioredoxin, and a critical agent in the in vivo regulation of glucose. The well-described induction of TXNIP by high glucose may represent an important pathogenic trigger of complications arising in the diabetic environment, with sustained overexpression of TXNIP triggering the increased production of reactive oxygen species and collagen, both major contributors to the development of diabetic nephropathy (DN). To examine a possible therapeutic role for targeted TXNIP inhibition in DN, transgenic (mRen-2)27 rats were rendered diabetic with streptozotocin and then treated with 20 μ,smlcap,M,/smlcap, TXNIP deoxyribozyme (DNAzyme) delivered continuously over 12 weeks by an implanted osmotic mini-pump. Renal injury was measured using biochemical parameters of kidney function along with histological markers of damage. Catalytic activity of TXNIP DNAzyme was determined by TXNIP gene and peptide expression in the rat ...
Compare peptidoglycan recognition protein 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
lipid transfer protein: accelerates glycolipid exchange; catalyzes net transfer of glycosphingolipids from brush border membrane vesicles; also facilitates transfer of glucosyl-, galactosyl- & lactosylceramide from liposomal vesicles to red ghost cells; see also record for phospholipid exchange protein
Figure 3. Identification of cardiac myosin binding protein-C (cMyBP-C) as a cardiac myocyte-specific PKGIα anti-remodeling substrate through molecular screen for PKGIa-LZ binding proteins. From Thoonen et al, 2015. (A) Outline of screening strategy. GST-fusion proteins were generated containing the PKGIa LZ domain (PKG1-59), the PKGIα mutated LZ domain (PKGLZM), or GST alone. The separate bait proteins were incubated with left ventricular protein lysates, followed by SDS PAGE and Coomassie staining. Protein bands selectively precipitating with PKG1-59 were removed and identified by mass spectroscopy. (B) Representative Coomassie stain from left ventricular protein lysates incubated with GST-fusion proteins. The 150 kDa band visible only in PKG1-59 precipitate (denoted by arrow) was excised and subjected to mass spectroscopy, revealing cMyBP-C as the predominant species. The thick bands between 25 and 30 kDa represent GST fusion proteins. Representative of 3 independent experiments. (C) Model ...
Recombinant human HIPK1 (156-555) was expressed in Sf9 cells using an N-terminal GST tag. HIPK1 or homeodomain-interacting protein kinase 1 is a ser/thr protein kinase and a member of the HIPK family.
|strong|Goat anti Human TRIM5 alpha antibody|/strong| recognizes an epitope within the N-terminal (NT) region of human TRIM5alpha, otherwise known as RNF88 (RING finger protein 88), a cytoplasmic pro…
Jones Day represented Balderton Capital, as co-investor along with Ventech, in connection with their purchase of €7.5 million (US$10 million) of Series B Convertible B Preferred Stock in a private placement by Vestiaire de Copines, an online luxury resale store for second-hand fashion products.
Blotting techniques allow the transfer of proteins and nucleic acids (DNA, RNA) from polyacrylamide or agarose gels onto carrier membranes. Additional these techniques allow immobilization of those components from solutions onto carrier membranes. On the membrane the proteins and nucleic acids offer open access (compared to in-gel techniques) for detection methods for specific molecules (e. g. antibodies). ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
19. 1.Carrier Concept - According to this hypothesis the carrier protein picks up an ion from one side of the membrane and discharges it on the other side. The picking up and discharge of the ion requires energy. Energy is obtained by hydrolysis of ATP. - ATP changes into ADP and energy released is used to change the conformation of the carrier which may be ATPase itself, so that the ion is picked up on one side of the membrane and released on the other. - After discharge of an ion, carrier protein is reprimed to pick up an other ion. The carrier protein may carry one ion inwards and may exchange it with another ion at the inner surface of membrane, so that the other ion is carried by the same carrier outwards. ...
19. 1.Carrier Concept - According to this hypothesis the carrier protein picks up an ion from one side of the membrane and discharges it on the other side. The picking up and discharge of the ion requires energy. Energy is obtained by hydrolysis of ATP. - ATP changes into ADP and energy released is used to change the conformation of the carrier which may be ATPase itself, so that the ion is picked up on one side of the membrane and released on the other. - After discharge of an ion, carrier protein is reprimed to pick up an other ion. The carrier protein may carry one ion inwards and may exchange it with another ion at the inner surface of membrane, so that the other ion is carried by the same carrier outwards. ...
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Buy our Recombinant Human TRIM35 protein. Ab161529 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA. Abcam provides free…
Lola Collignon tait une gamine de 11 ans avec plein de lucioles dans la t te et des r ves de petite fille en devenir. Elle marchait avec trois de ses copines sur le macadam dun passage prot g de Thionville, le c ur gai et l ger lapproche des f tes de No l. Lola Collignon na pas crois le p re No l mais une voiture de pompiers d glingu e qui zigzaguait dangereusement, la fauchant mortellement et blessant gri vement ses amies...
02/20/2008 0tbrewer None 1041:45 0:25 0:00 0:25 -- *CG 5stox1 u 0.04 55.61 d 1.15 106.13 u 0.45 47.12 d 0.03 50.35 u 0.68 23.58 *CG 5stox2 u 0.33 18.39 u 0.06 26.50 d 0.72 40.02 u 0.26 21.55 d 0.10 6.75 *CG 5stox3 u 0.60 49.48 u 0.06 25.91 u 0.33 13.04 u 1.54 74.47 u 0.09 20.99 *CG 5stox4 d 0.02 71.12 u 0.10 22.47 u 1.54 74.47 d 0.11 1.61 u 0.04 12.61 S BREAK-3 -- ...
CG amstox D 120.96 13110.05 D 25.81 2618.51 D 241.69 15154.61 *CG 6stox1 d 0.56 35.27 u 0.05 72.27 d 0.02 46.24 d 1.65 44.08 d 0.01 10.09 *CG 6stox2 d 1.19 34.26 d 1.34 37.71 u 0.13 90.68 d 0.70 38.31 d 0.41 26.84 *CG 6stox3 d 0.41 63.84 d 0.32 27.69 u 0.14 50.11 u 0.08 4.20 d 1.03 48.75 *CG 6stox4 d >> 2.20 68.70 d 0.48 43.04 d 2.07 40.28 d 0.31 46.20 d 0.44 81.16 ...
Does anyone use Trimus picks? Im curious to see peoples assessments. Also, does anyone use really round-edged picks (like mando-style picks)?
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TY - JOUR. T1 - Cross-species mechanical fingerprinting of cardiac myosin binding protein-C. AU - Karsai, Árpád. AU - Kellermayer, Miklós S Z. AU - Harris, Samantha P.. PY - 2013/6/4. Y1 - 2013/6/4. N2 - Cardiac myosin binding protein-C (cMyBP-C) is a member of the immunoglobulin (Ig) superfamily of proteins and consists of 8 Ig- and 3 fibronectin III (FNIII)-like domains along with a unique regulatory sequence referred to as the MyBP-C motif or M-domain. We previously used atomic force microscopy to investigate the mechanical properties of murine cMyBP-C expressed using a baculovirus/insect cell expression system. Here, we investigate whether the mechanical properties of cMyBP-C are conserved across species by using atomic force microscopy to manipulate recombinant human cMyBP-C and native cMyBP-C purified from bovine heart. Force versus extension data obtained in velocity-clamp experiments showed that the mechanical response of the human recombinant protein was remarkably similar to that of ...
Cardiac myosin binding protein C phosphorylation affects cross-bridge cycles elementary steps in a site-specific manner.: Based on our recent finding that card
Carnitine β-hydroxy-γ-(trimethylammonio)butyrate - a compound necessary in the peripheral tissues for a transfer of fatty acids for their oxidation within the cell, accumulates in the brain despite low β-oxidation in this organ. In order to enter the brain, carnitine has to cross the blood-brain barrier formed by capillary endothelial cells which are in close interaction with astrocytes. Previous studies, demonstrating expression of mRNA coding two carnitine transporters - organic cation/carnitine transporter 2 (OCTN2) and B|SUP|0,+|/SUP| in endothelial cells, did not give any information on carnitine transporters polarity in endothelium. Therefore more detailed experiments were performed on expression and localization of a high affinity carnitine transporter OCTN2 in an in vitro model of the blood-brain barrier by real-time PCR, western blot analysis, and immunocytochemistry. The amount of mRNA was comparable in endothelial cells and kidney, when referred to housekeeping genes, it was, however,
Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene. MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. Click on genes, proteins and metabolites below to link to respective articles. [[File: [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] ,px,alt=Statin Pathway edit]] The interactive pathway map can be edited at ...
Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.[1][2] MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.[2] Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. ...
It has been demonstrated previously that clinical phenotypes of HCM (hypertrophic cardiomyopathy) caused by mutations in the cardiac MyBP-C (myosin-binding protein C) gene show late onset, low penetrance and favourable clinical course. However, we have encountered severe phenotypes in several carriers of the MyBP-C gene mutations. The aim of the present study was to screen novel MyBP-C gene mutations in patients with HCM and to investigate the genetic differences in affected subjects with severe phenotypes. The MyBP-C gene was screened in 292 Japanese probands with HCM, and a novel c.2067+1G→A mutation was present in 15 subjects in five families. Clinical phenotypes of carriers of the c.2067+1G→A mutation were compared with those of a previously identified Arg820Gln (Arg820→Gln) mutation in the MyBP-C gene. The disease penetrance in subjects aged ≥30 years was 90% in carriers of the c.2067+1G→A mutation and 61% in carriers of the Arg820Gln mutation. Sudden death occurred in four ...
Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons
Abetalipoproteinemia (ABL) is an extremely rare autosomal recessive disorder, which is characterized by defective assembly and secretion of plasma apolipoprotein (apo) B-containing lipoproteins. ABL results from mutations in the gene encoding the microsomal triglyceride transfer protein (MTP). We se …
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
Although mutations in cMyBP‐C are one of the most frequent causes of hypertrophic cardiomyopathy on a per gene basis with ,150 individual mutations being documented, the majority of these mutations (≈60%) result not in a full‐length, mutated protein, but in a truncated peptide and these mutated alleles exhibit autosomal dominance.29, 30 We have shown that a truncated form of cMyBP‐C is produced from endogenous, normal cMyBP‐C as a result of ischemia-reperfusion injury and/or general cardiovascular stress and is generated from Ca2+ activated μ‐calpain activity.2 This fragment is stable, can be expressed inducibly in cardiomyocytes and causes cardiac disease, fibrosis, and eventually heart failure and death.4 This model displays pathology that is often seen in human cardiac fibrosis and myocardial disease: the hearts develop hypertrophy and show extensive interstitial fibrosis and perivascular fibrosis while maintaining systolic function. Thus, in terms of a fibrotic response, the ...
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Lipid-transfer proteins (LTP) are type of proteins, 9-kDa proteins present in high quantity as much as 4 percent of the total soluble protein in higher plants. Lipid-transfer proteins (LTP) are responsible for transfer (in vitro), of phospholipids between membranes as well as binds to acyl chains. Some important roles played by LTP are embryogenesis, participation in cutin formation, symbiosis, and the adaptation of plants to various environmental conditions and defense reactions against phytopathogens, though the validity of some these roles is needs to be determined. Recent studies show several important functions in the cell. Biosynthesis of many membrane lipids occurs at the (ER) endoplasmic reticulum, then they are dispensed by vesicular transport and lipid transfer proteins. Lysosomal lipid transfer proteins are types of proteins are multifunctional in nature. Though the mechanism and functions of most LTPs are yet to be determined, lipid transfer proteins in plants are involved in surface ...
SummaryThe main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.Methods1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.ResultsOne polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the ...
casSAR Dugability of A0AT31 | NLTP5 | Non-specific lipid-transfer protein 5 - Also known as NLTP5_LENCU, NLTP5. Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. MYBPC gene is linked to CMH4 and demonstrated a splice donor mutationin 1 family with familial hypertrophic cardiomyopathy and a duplication mutation in a second. Both mutations were predicted to disrupt the high-affinity, C-terminal myosin-binding domain of cardiac MyBP-C. Again, findings demonstrated that as in the case of the 3 forms that had been defined in molecular terms previously, familial hypertrophic cardiomyopathy is a disease of the sarcomere.
protease inhibitor/seed storage/lipid transfer protein (LTP) family protein; FUNCTIONS IN: lipid binding; INVOLVED IN: lipid transport; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Bifunctional inhibitor/plant lipid transfer protein/seed storage (InterPro:IPR016140), Plant lipid transfer protein/seed storage/trypsin-alpha amylase inhibitor (InterPro:IPR003612), Plant lipid transfer protein and hydrophobic protein, helical (InterPro:IPR013770); BEST Arabidopsis thaliana protein match is: protease inhibitor/seed storage/lipid transfer protein (LTP) family protein (TAIR:AT4G12510.1); Has 534 Blast hits to 530 proteins in 51 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 534; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink ...
TY - JOUR. T1 - Acyl-CoA binding protein is an essential protein in mammalian cell lines. AU - Knudsen, Jens. AU - Færgeman, Nils J.. PY - 2002/12/15. Y1 - 2002/12/15. N2 - In the present work, small interference RNA was used to knock-down acyl-CoA binding protein (ACBP) in HeLa, HepG2 and Chang cells. Transfection with ACBP-specific siRNA stopped growth, detached cells from the growth surface and blocked thymidine and acetate incorporation. The results show that depletion of ACBP in mammalian cells results in lethality, suggesting that ACBP is an essential protein.. AB - In the present work, small interference RNA was used to knock-down acyl-CoA binding protein (ACBP) in HeLa, HepG2 and Chang cells. Transfection with ACBP-specific siRNA stopped growth, detached cells from the growth surface and blocked thymidine and acetate incorporation. The results show that depletion of ACBP in mammalian cells results in lethality, suggesting that ACBP is an essential protein.. KW - Acetates. KW - ...
The aim of our study was to investigate the predictive value of the biomarkers interleukin 6 (IL-6), interleukin 10 (IL-10) and lipopolysaccharide-binding protein (LBP) compared with clinical CRB and CRB-65 severity scores in patients with community-acquired pneumonia (CAP). Samples and data were obtained from patients enrolled into the German CAPNETZ study group. Samples (blood, sputum and urine) were collected within 24 h of first presentation and inclusion in the CAPNETZ study, and CRB and CRB-65 scores were determined for all patients at the time of enrollment. The combined end point representative of a severe course of CAP was defined as mechanical ventilation, intensive care unit treatment and/or death within 30 days. Overall, a total of 1,000 patients were enrolled in the study. A severe course of CAP was observed in 105 (10.5%) patients. The highest IL-6, IL-10 and LBP concentrations were found in patients with CRB-65 scores of 3-4 or CRB scores of 2-3. IL-6 and LBP levels on enrollment in the
Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids exhibit both beneficial and toxic properties, their release from LDs must be controlled. Here we demonstrate that yeast Sfh3, an unusual Sec14-like phosphatidylinositol transfer protein, is an LD-associated protein that inhibits lipid mobilization from these particles. We further document a complex biochemical diversification of LDs during sporulation in which Sfh3 and select other LD proteins redistribute into discrete LD subpopulations. The data show that Sfh3 modulates the efficiency with which a neutral lipid hydrolase-rich LD subclass is consumed during biogenesis of specialized membrane envelopes that package replicated haploid meiotic genomes. These results present novel insights into the interface between phosphoinositide signaling and developmental regulation of LD metabolism and unveil meiosis-specific aspects of Sfh3 (and ...
TY - JOUR. T1 - Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy. AU - Brauch, Katharine M.. AU - Karst, Margaret L.. AU - Herron, Kathleen J.. AU - de Andrade, Mariza. AU - Pellikka, Patricia A.. AU - Rodeheffer, Richard J.. AU - Michels, Virginia V.. AU - Olson, Timothy M.. PY - 2009/9/1. Y1 - 2009/9/1. N2 - Objectives: We sought to identify a novel gene for dilated cardiomyopathy (DCM). Background: DCM is a heritable, genetically heterogeneous disorder that remains idiopathic in the majority of patients. Familial cases provide an opportunity to discover unsuspected molecular bases of DCM, enabling pre-clinical risk detection. Methods: Two large families with autosomal-dominant DCM were studied. Genome-wide linkage analysis was used to identify a disease locus, followed by fine mapping and positional candidate gene sequencing. Mutation scanning was then performed in 278 unrelated subjects with idiopathic DCM, prospectively identified at the Mayo Clinic. ...
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We have purified a 38 kDa protein from bovine brain which is cross-reactive with an affinity purified antibody against the 35 kDa phosphatidylino-sitol transfer protein from the same source. Controlled trypsinization of the 38 kDa protein yielded an immunoreactive protein of 35 kDa which displayed a 6-fold increase in phosphatidylinositol transfer activity and a IO-fold higher affinity for this phospholipid. The possibility that the 38 kDa protein is a precursor of the phosphatidylinositol transfer protein is discussed.(C) 1990 Elsevier Science B.V. All rights reserved ...
Read Comparative study of the genomic organization of DNA repeats within the 5′-flanking region of the natural resistance-associated macrophage protein gene (NRAMP1) between humans and great apes, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and post-translational modifications including phosphorylation and acetylation. Here we demonstrate that the human serine/threonine kinase homeodo …
Lipid Transfer Proteins (LTPs) are found in plants and foods that contain plants. Lipid Transfer Protein Syndrome is an allergy affecting people who have become sensitised to LTPs.
El Archivo Digital UPM alberga en formato digital la documentacion academica y cientifica (tesis, pfc, articulos, etc..) generada en la Universidad Politecnica de Madrid.Los documentos del Archivo Digital UPM son recuperables desde buscadores: Google, Google Academics, Yahoo, Scirus, etc y desde recolectores OAI: E-ciencia, DRRD, Recolecta (REBIUN-FECYT), Driver, Oaister, etc.
1FK0: Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
1FK7: Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
What is Ligand Binding Protein Gene? Definition of Ligand Binding Protein Gene. Ligand Binding Protein Gene FAQ. Learn more about Ligand Binding Protein Gene. Ligand Binding Protein Gene facts.
Monte S. Willis, MD, PhD - $50,000 Familial hypertrophic cardiomyopathies (FHC) are the most common underlying cause of sudden death in children and young adults, which result from mutations primarily in proteins responsible for heart contraction. It has been identified that the cardiac specific protein MuRF1 (Muscle Ring Finger-1), mediates the degradation of one of these proteins, the cardiac Myosin Binding Protein-C (cMyBP-c). Since cMyBP-c is the most commonly mutated protein in patients with FHC, and cMyBP-c is degraded very rapidly by heart cells in these patients, this study proposes that MuRF1 may be a key regulator of this degradation as a mechanism to clear damaged proteins. Moreover, it has been identified that MURF1 regulates the turnover of proteins that transport energy (ATP) throughout the cell, and that MuRF1 inhibits increases in muscle size (cardiomyocyte hypertrophy). Therefore, the assumption is that MuRF1 is a unifying mechanism for the major underlying defects in FHC. The ...
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MAYWOOD, Ill. - A new blood test can detect heart attacks hours faster than the current gold-standard blood test, according to a study led by Loyola University Chicago Stritch School of Medicine researchers.. The new test measures a protein that is released to the bloodstream by dying heart muscle. The protein is called cardiac myosin binding protein-C (cMyBP-C). The study found that cMyBP-C is released to the blood within just 15 minutes of cardiac damage, and rises to significant levels in three hours.. This is a potential ultra-early biomarker that could confirm whether a patient has had a heart attack, leading to faster and more effective treatment, said Sakthivel Sadayappan, PhD, senior author of the study, published Dec. 13, 2013 in the American Journal of Physiology - Heart and Circulatory Physiology.. Between 60 and 70 percent of all patients who complain of chest pain do not have heart attacks. Many of these patients are admitted to the hospital, at considerable time and expense, ...
In the present work, small interference RNA was used to knock-down acyl-CoA binding protein (ACBP) in HeLa, HepG2 and Chang cells. Transfection with ACBP-specific siRNA stopped growth, detached cells from the growth surface and blocked thymidine and acetate incorporation. The results show that depletion of ACBP in mammalian cells results in lethality, suggesting that ACBP is an essential protein.. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Signaling through the Hippo-Salvador-Warts (Wts) kinase cascade inhibits cell proliferation and promotes apoptosis by preventing nuclear accumulation of the transcriptional coactivator Yorkie (Yki in the fruit fly) or Yap (in vertebrates). Hippo-dependent phosphorylation of Yki by Wts prevents nuclear accumulation of Yki. In the nucleus, Yki cooperates with its partner Scalloped to promote expression of several target genes that inhibit apoptosis and promote mitosis. Two studies report that the serine-threonine kinase homeodomain-interacting protein kinase (Hipk) promotes Yki activity. Studies by Chen and Verheyen and by Poon et al. both demonstrate that, like overexpresison of yki or knockdown of wts, overexpresison of hipk in fly imaginal discs caused excessive cell proliferation, leading to tissue overgrowth, and stimulation of endogenous Yki transcriptional targets and reporter constructs. Reducing Hipk activity by mutation or RNA interference (RNAi) reduced both tissue size and expression ...
LBP [LPS (lipopolysaccharide)-binding protein] was discovered approximately 25 years ago. Since then, substantial progress has been made towards our understanding of its function in health and disease. Furthermore, the discovery of a large protein family sharing functional and structural attributes has helped in our knowledge. Still, key questions are unresolved, and here an overview on the old and new findings on LBP is given. LBP is an acute-phase protein of the liver, but is also synthesized in other cells of the organism. While LBP is named after the ability to bind to LPS of Gram-negative bacteria, it also can recognize other bacterial compounds, such as lipopeptides. It has been shown that LBP is needed to combat infections; however, the main mechanism of action is still not clear. New findings on natural genetic variations of LBP leading to functional consequences may help in further elucidating the mechanism of LBP and its role in innate immunity and disease. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Protein features are: Cellular retinaldehyde binding/alpha-tocopherol transport; Cellular retinaldehyde-binding/triple function, C-terminal; Phosphatidylinositol transfer protein-like, N-terminal ...
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Integral membrane proteins (SCAMPs), tetraspan vesicle membrane proteins) that act as carriers, recycling proteins to the cell surface. At least three members of the family have been identified in humans: SCAMP1 (338 aa), SCAMP2 (329 aa), and SCAMP3 (347 aa). ...
DBI - DBI (untagged)-Human diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) (DBI), transcript variant 1 available for purchase from OriGene - Your Gene Company.
Recombinant GRB2-Related Adaptor Protein (GRAP) Protein (Myc-DYKDDDDK Tag). Species: Human. Source: HEK-293 Cells. Order product ABIN2722222.
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP ...
4'-Phosphopantetheine is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty ... the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). Cronan ... Acyl Carrier Protein at the US National Library of Medicine Medical Subject Headings (MeSH) (Proteins). ... The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most ...
A homologous protein, which can be rendered ineffective by the antibody to pure chicken riboflavin carrier protein, has been ... Riboflavin carrier proteins (RFCPs) together with human serum albumin transport flavin mononucleotide (FMN) in the blood ... Studies from India have identified a riboflavin carrier protein (RCP) present in bird (e.g., chicken) eggs, which is considered ... Karande, Anjali A.; Sridhar, Lakshmi; Gopinath, K. S.; Adiga, P. Radhakantha (2001). "Riboflavin carrier protein: A serum and ...
Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and ... The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of ... Sterol carrier proteins in SCOP SCP-2 sterol transfer family in Pfam UMich Orientation of Proteins in Membranes families/ ... These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of ...
Haem or Heme carrier protein 1 (HCP1) was originally identified as mediating heme-Fe transport although it later emerged that ... v t e (Human proteins, All stub articles, Protein stubs). ... of human proton-coupled folate transporter/heme carrier protein ...
... is a protein that in humans is encoded by the SLC25A3 gene. The encoded protein is a ... "SLC25A3 - Phosphate carrier protein, mitochondrial precursor - Homo sapiens (Human) - SLC25A46 gene & protein". ... "SLC25A3 - Phosphate carrier protein, mitochondrial". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Dolce V, ... "Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3". This article incorporates ...
... (BCCP) refers to proteins containing a biotin attachment domain that carry biotin and ... Proteins, All stub articles, Enzyme stubs, Protein stubs). ... the BCCP is a separate protein known as accB (P0ABD8). On the ...
The enzyme [acyl-carrier-protein] phosphodiesterase (EC catalyzes the reaction holo-[acyl-carrier-protein] + H2O ⇌ {\ ... Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase". J. Biol. Chem. 242 (8): 1776-81. ... The systematic name is holo-[acyl-carrier-protein] 4′-pantetheine-phosphohydrolase. Other names in common use include ACP ... Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and ...
... dodecanoyl-acyl-carrier-protein hydrolase, dodecyl-acyl-carrier protein hydrolase, and dodecanoyl-[acyl-carrier protein] ... The enzyme dodecanoyl-[acyl-carrier-protein] hydrolase (EC catalyzes the reaction a dodecanoyl-[acyl-carrier-protein ... acyl-carrier-protein] hydrolase. Other names in common use include lauryl-acyl-carrier-protein hydrolase, ... acyl-carrier-protein] + dodecanoate This enzyme belongs to the family of hydrolases, specifically those acting on thioester ...
The systematic name is oleoyl-[acyl-carrier-protein] hydrolase. Other names in common use include acyl-[acyl-carrier-protein] ... The enzyme oleoyl-[acyl-carrier-protein] hydrolase (EC catalyzes the reaction an oleoyl-[acyl-carrier-protein] + H2O ... acyl-acyl carrier protein hydrolase, oleoyl-ACP thioesterase, and oleoyl-acyl carrier protein thioesterase. This enzyme ... The function of acyl thioesterases in the metabolism of acyl-coenzymes A and acyl-acyl carrier proteins". Arch. Biochem. ...
... acyl carrier protein synthetase (ACPS), PPTase, acyl carrier protein synthase, P-pant transferase, and CoA:apo-[acyl-carrier- ... Elovson J, Vagelos PR (July 1968). "Acyl carrier protein. X. Acyl carrier protein synthetase". The Journal of Biological ... Acyl Carrier Protein):Holo-(Acyl Carrier Protein) Synthase Complex". Journal of Molecular Biology. 429 (23): 3763-3775. doi: ... apo-acyl carrier protein ⇌ {\displaystyle \rightleftharpoons } adenosine 3',5'-bisphosphate + holo-acyl carrier protein This ...
Schultz, D; Suh, M.; Ohlrogge (2000). "Stearoyl-Acyl Carrier Protein and Unusual Acyl-Acyl Carrier Protein Desaturase ... acyl-carrier-protein] + acceptor + 2 H2O The systematic name of this enzyme class is acyl-[acyl-carrier-protein], hydrogen- ... acyl-carrier-protein), reduced acceptor, and O2, whereas its 3 products are oleoyl-(acyl-carrier-protein), acceptor, and H2O. ... "Stearoyl-acyl carrier protein delta 9 desaturase from Ricinus communis is a diiron-oxo protein". Proceedings of the National ...
... (EC, thiF (gene)) is an enzyme with systematic name ATP:(ThiS) ... Sulfur+carrier+protein+ThiS+adenylyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: ... The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine. Taylor SV, ... identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex ...
... acyl-carrier-protein] hydro-lyase, beta-hydroxybutyryl acyl carrier protein dehydrase, beta-hydroxybutyryl acyl carrier protein ... enoyl acyl carrier protein hydrase, crotonyl acyl carrier protein hydratase, 3-hydroxybutyryl acyl carrier protein dehydratase ... MAJERUS PW, ALBERTS AW, VAGELOS PR (1965). "ACYL CARRIER PROTEIN. 3. AN ENOYL HYDRASE SPECIFIC FOR ACYL CARRIER PROTEIN ... acyl-carrier-protein]]], and two products, [[but-2-enoyl-[acyl-carrier-protein]]] and H2O. This enzyme belongs to the family of ...
Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific) Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) Cis-2- ... Enoyl-acyl carrier protein reductase (or ENR) (EC, is a key enzyme of the type II fatty acid synthesis (FAS) system. ... acyl-carrier protein) reductase from Plasmodium falciparum". The Biochemical Journal. 381 (Pt 3): 735-41. doi:10.1042/ ... "Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase". Antimicrobial Agents and ...
... is a protein that in humans is encoded by the SLC25A14 gene. Mitochondrial uncoupling ... Solute carrier family Uncoupling protein GRCh38: Ensembl release 89: ENSG00000102078 - Ensembl, May 2017 GRCm38: Ensembl ... proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative ... "Entrez Gene: SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14". Ricquier D, Bouillaud F (2000). "The ...
... acyl-carrier-protein] Thus, the two substrates of this enzyme are acetyl-CoA and acyl carrier protein, whereas its two products ... acyl-carrier-protein] S-acetyltransferase. Other names in common use include acetyl coenzyme A-acyl-carrier-protein ... Rangan VS, Smith S (1997). "Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S- ... In enzymology, a [acyl-carrier-protein] S-acetyltransferase (EC is an enzyme that catalyzes the reversible chemical ...
... acyl carrier protein ⇌ CoA + malonyl-[acyl-carrier-protein] The transfer of malonate to acyl-carrier-protein (ACP) converts the ... Other names in common use include malonyl coenzyme A-acyl carrier protein transacylase, [acyl carrier protein] ... acyl carrier protein ⇌ CoA + malonyl-[acyl-carrier-protein] Thus, the two substrates of this enzyme are malonyl-CoA and acyl ... carrier protein, whereas its two products are CoA and malonyl-acyl-carrier-protein. This enzyme belongs to the family of ...
... acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase ... Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP ... beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, 3-ketoacyl ACP reductase, NADPH- ... acyl-carrier-protein](ACP) + NADPH + H+ ⇌ {\displaystyle \rightleftharpoons } (3R)-3-hydroxyacyl-[acyl-carrier-protein](ACP) + ...
... acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein ... acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase ... acyl-carrier protein] ⇌ {\displaystyle \rightleftharpoons } a trans-dec-2-enoyl-[acyl-carrier protein] + H2O (2) a (3R)-3- ... acyl-carrier protein] ⇌ {\displaystyle \rightleftharpoons } a cis-dec-3-enoyl-[acyl-carrier protein] + H2O This enzyme is ...
... acyl-carrier-protein) synthase (EC is an enzyme with systematic name octanoyl-CoA:malonyl-(acyl-carrier protein) C- ... acyl-carrier protein] ⇌ {\displaystyle \rightleftharpoons } 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 This enzyme is ... Beta-ketodecanoyl-(acyl-carrier-protein)+synthase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal ...
... acyl carrier protein] dehydratase, D-3-hydroxyoctanoyl-acyl carrier protein dehydratase, beta-hydroxyoctanoyl-acyl carrier ... acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3- ... acyl-carrier-protein] dehydratase (EC catalyzes the chemical reaction (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein ... acyl-carrier-protein] + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon- ...
... acyl-carrier-protein] hydro-lyase (hexadec-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3- ... acyl-carrier-protein]]], and two products, [[hexadec-2-enoyl-[acyl-carrier-protein]]] and H2O. This enzyme belongs to the ... acyl-carrier-protein] ⇌ {\displaystyle \rightleftharpoons } hexadec-2-enoyl-[acyl-carrier-protein] + H2O Hence, this enzyme has ... acyl-carrier-protein] dehydratase, beta-hydroxypalmitoyl-acyl carrier protein dehydrase, beta-hydroxypalmitoyl thioester ...
... is a protein that in humans is encoded by the SLC25A12 gene. Aralar is an ... "SLC25A12 - Calcium-binding mitochondrial carrier protein Aralar1 - Homo sapiens (Human) - SLC25A12 gene & protein". www.uniprot ... "SLC25A12 - Calcium-binding mitochondrial carrier protein Aralar1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). ... The protein encoded by SLC25A12, Aralar1, is a mitochondrial calcium-binding carrier that facilitates the calcium-dependent ...
... (EC, [BtrI acyl-carrier protein]-L-glutamate ligase, BtrJ) is an ... BtrI acyl-carrier protein] (2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] ⇌ {\displaystyle \ ... butirosin+acyl-carrier+protein)-L-glutamate+ligase at the US National Library of Medicine Medical Subject Headings (MeSH) ... BtrI acyl-carrier protein] This enzyme catalyses two steps in the biosynthesis of the side chain of the aminoglycoside ...
... acyl-carrier-protein]]], and one product, [[cis-dec-3-enoyl-[acyl-carrier-protein]]]. This enzyme belongs to the family of ... acyl-carrier-protein] ⇌ {\displaystyle \rightleftharpoons } cis-dec-3-enoyl-[acyl-carrier-protein] Hence, this enzyme has one ... The systematic name of this enzyme class is decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase. Other names in ... In enzymology, a trans-2-decenoyl-[acyl-carrier protein] isomerase (EC is an enzyme that catalyzes the chemical ...
... acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine ⇌ {\displaystyle \rightleftharpoons } [acyl-carrier protein ... The systematic name of this enzyme class is acyl-[acyl-carrier protein]:O-(2-acyl-sn-glycero-3-phospho)ethanolamine O- ... In enzymology, an acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase (EC is an enzyme that catalyzes the ... Other names in common use include acyl-[acyl-carrier, protein]:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine, and O- ...
... acyl-carrier protein] + diphosphate The delta subunit of malonate decarboxylase serves as an acyl-carrier protein (ACP) . ... Malonate+decarboxylase+holo-(acyl-carrier+protein)+synthase at the US National Library of Medicine Medical Subject Headings ( ... Malonate decarboxylase holo-(acyl-carrier protein) synthase (EC, holo ACP synthase, '2'-(5''-triphosphoribosyl)-3'- ... acyl-carrier protein] ⇌ {\displaystyle \rightleftharpoons } malonate decarboxylase holo-[ ...
BtrI acyl-carrier protein] ⇌ {\displaystyle \rightleftharpoons } 4-amino butanoyl-[BtrI acyl-carrier protein] + CO2 This enzyme ... L-glutamyl-(BtrI acyl-carrier protein) decarboxylase (EC, btrK (gene)) is an enzyme with systematic name L-glutamyl-( ... L-glutamyl-(BtrI+acyl-carrier+protein)+decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH) ... BtrI acyl-carrier protein) carboxy-lyase. This enzyme catalyses the following chemical reaction L-glutamyl-[ ...
... acyl-carrier-protein) reductase (EC, long-chain acyl-[acp] reductase, fatty acyl-[acyl-carrier-protein] reductase, ... acyl-carrier protein + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } a long-chain acyl-[acyl-carrier protein] + NAD(P)H + H+ ... Long-chain+acyl-(acyl-carrier-protein)+reductase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal ... acyl-carrier protein)-forming). This enzyme catalyses the following chemical reaction a long-chain aldehyde + ...
... acyl-carrier-protein] + NADH + H+ Thus, the two substrates of this enzyme are [[(3R)-3-hydroxyacyl-[acyl-carrier-protein]]] and ... acyl-carrier-protein]:NAD+ oxidoreductase. Other names in common use include 3-oxoacyl-[acyl carrier protein] (reduced ... In enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) (EC is an enzyme that catalyzes the chemical ... acyl-carrier-protein]]], NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the ...
The law requires 50% of Title II grains to be bagged in the U.S. and 75% of U.S. food aid must ship on U.S. flag carrier ... protein, and energy. Value-added food aid products such as corn soy blend and wheat soy blend have provided nutrition to ...
The mutant allele PTGS2 5939C carriers among the Han Chinese population have been shown to have a higher risk of gastric cancer ... Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 ... PTGS (COX, which can be confused with "cytochrome oxidase") enzymes are monotopic membrane proteins; the membrane-binding ... of the protein. The catalytic domain is homologous to mammalian peroxidases such as myeloperoxidase. It has been found that ...
This enzyme catalyses the following chemical reaction (3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3- ... acyl-carrier protein] The enzyme catalyses a step of lipid A biosynthesis. Bartling CM, Raetz CR (September 2009). "Crystal ... acyl-carrier protein):UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine N-acetyltransferase. ...
... a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2). The most variable region of the viral ... Homozygous carriers of any nonsense mutation in the FUT2 gene are called non-secretors, as no ABH-antigen is produced. ... The protein MDA-5 may be the primary immune sensor that detects the presence of noroviruses in the body. Some people have ... The vaccine relies on using a virus-like particle that is made of the norovirus capsid proteins in order to mimic the external ...
... but many nuclear proteins possess their own. PANO1 overlaps solute carrier family 25 member 22 (SLC25A22). A causal link ... "Protein BLAST: search protein databases using a protein query". Retrieved 2021-08-01. (CS1 maint: url- ... Stimulating protein 1, CCAAT/enhancer binding protein, GC box elements and HMG box-containing protein 1. Like previously ... PANO1 is a protein which in humans is encoded by the PANO1 gene. PANO1 is an apoptosis inducing protein that is able to ...
The drug has also been assessed at steroid hormone-associated carrier proteins, and shows very low binding to sex hormone- ... Ulrich Westphal (6 December 2012). Steroid-Protein Interactions II. Springer Science & Business Media. pp. 501-. ISBN 978-3-642 ...
It occurs in males and in homozygous females (which is only possible in the daughters of a haemophilic male and a carrier or ... About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein, ... so it is recommended that levels of factor VIII and IX be measured in all known or potential carriers prior to surgery and in ...
The syndrome is caused by mutations in both copies of the CENPF gene, which codes for centromere protein F. This protein is ... Once a family has been identified as being carriers for mutated CENPF genes, prenatal diagnosis and preimplantation genetic ... CENPF codes for centromere protein F. Centromere proteins are involved in the separation of chromosomes during cell division. ... Microtubules are protein structures that are part of the cytoskeleton and are necessary for cells to have diverse, complex ...
None of Snowflake's offspring was albino, but all should be heterozygous, recessive carriers, for the albino gene. Half of his ... A.21 Gerritsen, Vivienne Baillie (August 2004) "Snowy stardom". Protein Spotlight (SIB Swiss Institute of Bioinformatics). ... If both parents were albino gene carriers, they have 25% chance of producing an albino offspring. As of September 2021, ...
Proton myo-inositol cotransporter, also known as solute carrier family 2 member 13 is a protein that in humans is encoded by ... "SLC2A13 solute carrier family 2 member 13 [ Homo sapiens (human) ]". Retrieved 2021-04-18. Uldry M, Ibberson M, Horisberger JD ... v t e v t e (Genes on human chromosome 12, Solute carrier family, All stub articles, Human chromosome 12 gene stubs, Membrane ...
Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. Many proteins are enzymes that catalyze ... It also serves as a carrier of phosphate groups in phosphorylation reactions. A vitamin is an organic compound needed in small ... In prokaryotes, these proteins are found in the cell's inner membrane. These proteins use the energy from reduced molecules ... Amino acids are made into proteins by being joined in a chain of peptide bonds. Each different protein has a unique sequence of ...
1998). "Import of mitochondrial carriers mediated by essential proteins of the intermembrane space". Science. 279 (5349): 369- ... These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[ ... TIMM10 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the ... related mitochondrial import proteins". Genomics. 61 (3): 259-67. doi:10.1006/geno.1999.5966. PMID 10552927. "Entrez Gene: ...
Solute carrier family, All stub articles, Membrane protein stubs). ... The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in ... "Entrez Gene: SLC27A2 solute carrier family 27 (fatty acid transporter), member 2". Perez VM, Gabell J, Behrens M, Wase N, ... Solute carrier family GRCh38: Ensembl release 89: ENSG00000140284 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
This species of Rickettsia uses an abundant cell surface protein called OmpB to attach to a host cell membrane protein called ... Though it would be decades before scientists discovered the tick as the carrier of the disease, in as early as 1866, Doctor ... CDC42, protein tyrosine kinase, phosphoinositide 3-kinase, and Src-family kinases then activate Arp2/3. This causes the ... Both rOmpA and rOmpB are members of a family of surface cell antigens (Sca) which are autotransporter proteins; they act as ...
Alternatively spliced transcript variants encoding the same protein have been found for this gene. Solute carrier family GRCh38 ... Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene. This gene encodes a ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ... "Entrez Gene: SLC27A6 solute carrier family 27 (fatty acid transporter), member 6". Stelzl U, Worm U, Lalowski M, et al. ( ...
Protein-protein interactions play a very important role in Na⁺-K⁺ pump-mediated signal transduction. For example, the Na⁺-K⁺ ... Another important task of the Na⁺-K⁺ pump is to provide a Na⁺ gradient that is used by certain carrier processes. In the gut, ... this membrane protein can also relay extracellular ouabain-binding signalling into the cell through regulation of protein ... A cell's osmolarity is the sum of the concentrations of the various ion species and many proteins and other organic compounds ...
S. rimosus's oxytetracycline polyketide synthase acyl carrier protein differs from most ACPs by having a C-terminus extension. ...
Acrodermatitis enteropathica is an inherited deficiency of the zinc carrier protein ZIP4 resulting in inadequate zinc ... In its structural role, zinc coordinates with certain protein domains, facilitating protein folding and producing structures ... a severe defect in zinc absorption due to a congenital deficiency in the zinc carrier protein ZIP4 in the enterocyte. Mild zinc ... In 2002 the zinc transporter protein ZIP4 was first identified as the mechanism for absorption of zinc in the gut across the ...
Notable types of predictive medicine through health care professionals include: Carrier testing: Carrier testing is done to ... On a protein level, structure is less conserved than sequence. Therefore, in many diseases, having the faulty gene still does ... If both parents are tested, carrier testing can provide information about a couple's risk of having a child with a genetic ...
... s play a role in the co-translational modification of proteins known as N-glycosylation in the form of dolichol ... The increase in the sugar carrier dolichyl phosphate may reflect an increased rate of glycosylation in the diseased brain, and ... Dolichol is also involved in transfer of the monosaccharides to the forming Glc3-Man9-GlcNAc2-Dolichol carrier. In addition, ... Polyprenols perform similar functions within bacteria; that is, they function as glycosyl carrier lipids involved in formation ...
American bullfrogs (Lithobates catesbeianus), also widely distributed, are also thought to be carriers of the disease due to ... proteins and amino acids. B. dendrobatidis also contains a variety of proteolytic enzymes and esterases that help it digest ... it has been suggested transportation of asymptomatic carrier species (e.g. Lithobates catesbeianus, the American Bullfrog) may ...
... nucleocapsid protein (N), and the spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat ... These asymptomatic carriers tend not to get tested and can still spread the disease. Other infected people will develop ... interferon gamma-induced protein 10 (IP‑10), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein 1‑alpha ... The S-protein, otherwise known as the spike protein, is the viral component that attaches to the host receptor via the ACE2 ...
Sons of carriers have a 50 percent chance of inheriting the disorder. Daughters have a 50 percent chance of inheriting the X- ... Inside cells under normal conditions, lysosomes convert, or metabolize, lipids and proteins into smaller components to provide ... Prenatal testing also is available to determine whether the fetus will have the disease or is a carrier. There are no specific ... Affected men do not pass the disorder to their sons, but their daughters will be carriers for the disorder.[citation needed] ...
... or NID may refer to: Nidogen-1, an extracellular protein Neuronal intestinal dysplasia, a condition involving abnormalities ... providing demarcation between carrier and customer wiring Naval Intelligence Department (Royal Navy), the intelligence arm of ...
The exact process by which Candida species switch from acting as normal oral commensals (saprophytic) state in the carrier to ... This adhesion involves adhesins (e.g., hyphal wall protein 1), and extracellular polymeric materials (e.g., mannoprotein). ... With more sensitive detection techniques, this figure is reported to rise to 90%. This candidal carrier state is not considered ...
Membrane proteins, Neurotransmitter transporters, Solute carrier family, Molecular neuroscience, All stub articles, Membrane ... This protein is an integral membrane protein that transports the monoamine neurotransmitters (serotonin, dopamine, ... The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by ...
... the H3 receptor is a G-protein coupled receptor. The H3 receptor is coupled to the Gi G-protein, so it leads to inhibition of ... Hatta E, Yasuda K, Levi R (Nov 1997). "Activation of histamine H3 receptors inhibits carrier-mediated norepinephrine release in ... July 2005). "G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state ... activating some G-protein coupled pathways but not others) Imbutamine (also H4 agonist) Immepip Imetit Immethridine Methimepip ...
The secreted protein consists of 133`amino acids (mouse Lect2 consists of two varieties a typical 151 amino acid protein and an ... Nonetheless, not all homozygous carriers of the variant ever exhibit LECT2 amyloidosis. A second SNP commonly found in Mexicans ... The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. ... LECT2 protein is widely expressed in vascular tissues, smooth muscle cells, adipocytes, cerebral neurons, apical squamous ...
When compared with non-carriers, LDLR mutation carriers had higher plasma LDL cholesterol, whereas APOA5 mutation carriers had ... This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like ... e.g. a truncation of the receptor protein at residue number 660 leads to domains 3,4 and 5 of the EGF precursor domain being ... This precludes the movement of the receptor from the ER to the Golgi, and leads to degradation of the receptor protein. Class 3 ...
Major fields of application were derived from the fact that S-layer proteins could be fused with other functional proteins (e.g ... ligands, antigens, antibodies, enzymes, peptides) and assembled on solid carriers (e.g. metals, semiconductors, graphene, ... Biomimetic interfaces comprised of S-layer proteins, lipid membranes and membrane proteins. J. R. Soc. Interface 11 (2014) ... S-layer fusion proteins - construction principles and applications. Curr. Opin. Biotech. 22(6) (2011) 824-831. Schuster, B., U. ...
Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp. ... BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE II. A. 416. Synechocystis sp. PCC 6803. Mutation(s): 0 EC: (PDB Primary ... Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp.. *PDB DOI: 10.2210/pdb1E5M/pdb ... The Crystal Structure of Beta-Ketoacyl-Acyl Carrier Protein Synthase II from Synechocystis Sp. At 1.54 A Resolution and its ...
Protein target information for Solute carrier family 35 member A3 (pig). Find diseases associated with this biological target ...
The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or ... Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. ... 108090000623 proteins and genes Proteins 0.000 title claims abstract description 77 * 239000000969 carrier Substances 0.000 ... Biological carriers for the delivery of proteins or peptides - Google Patents. Biological carriers for the delivery of proteins ...
Tag Archives: Malonyl CoA Acyl carrier protein transacylase. Cure for Skin Cancer…? RNA!. Posted on March 16, 2015 by seungwon ... Tagged health, Malonyl CoA Acyl carrier protein transacylase, MCAT, ribosome, RNA, skin-cancer, tissues, treatment, tumors ... We want to find a single protein out all of these that is only expressed in skin cancers and not in healthy skin cells and its ... Normally, a ribosome translates a messenger RNA in order to produce the mature MCAT protein. However, translation can be ...
holo-[acyl-carrier protein]. + H2O. = 4-phosphopantetheine. + apo-[acyl-carrier protein]. Synonyms. ACP phosphodiesterase, ... acyl-carrier-protein] phosphodiesterase. This is an abbreviated version!. For detailed information about [acyl-carrier-protein ... holofatty acid synthetase hydrolase, 4-phosphopantetheine hydrolase, ACP hydrolase, acyl carrier protein phosphodiesterase, ...
Mycobacterial heat-shock proteins as carrier molecules / C. Barrios ... [‎et al.]‎. II., The use of the 70-kDa mycobacterial ... 1992)‎. Mycobacterial heat-shock proteins as carrier molecules / C. Barrios ... [‎et al.]‎. II., The use of the 70-kDa ... heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin ... mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette ...
Has very low activity with substrates not bound to an acyl-carrier protein. ...
Acyl-acyl carrier protein (ACP) thioesterases (Fat) are essential components of the plant plastid-localized fatty acid synthase ... The Lotus japonicus acyl-acyl carrier protein thioesterase FatM is required for mycorrhiza formation and lipid accumulation of ... The Lotus japonicus acyl-acyl carrier protein thioesterase FatM is required for mycorrhiza formation and lipid accumulation of ... by phenotypically analyzing fatm mutant lines and by studying the biochemical function of the recombinant FatM protein. Reduced ...
Acyl-Carrier Protein S-Malonyltransferase*Acyl-Carrier Protein S-Malonyltransferase. *Acyl Carrier Protein S Malonyltransferase ... "Acyl-Carrier Protein S-Malonyltransferase" by people in this website by year, and whether "Acyl-Carrier Protein S- ... "Acyl-Carrier Protein S-Malonyltransferase" is a descriptor in the National Library of Medicines controlled vocabulary ... Below are the most recent publications written about "Acyl-Carrier Protein S-Malonyltransferase" by people in Profiles. ...
... a triclosan-resistant enoyl-acyl carrier protein reductase. Together they form a unique fingerprint. ...
Conjugate Vaccine Carrier Proteins. Protein conjugates used in Hib conjugate vaccines produced in the United States include ... Conjugation with a protein carrier improves the effectiveness of polysaccharide vaccines by inducing T-lymphocyte-dependent ... Monoclonal antibody to respiratory syncytial virus F protein (e.g., Synagis [MedImmune])(g). 15 mg/kg IM. None. ... meningococcal protein conjugate) with either measles-mumps-rubella vaccine or diphtheria-tetanus-pertussis and oral poliovirus ...
Sterol Carrier Protein 2 Antibody is a Rabbit Polyclonal against Sterol Carrier Protein 2. ... Sterol Carrier Protein 2 Antibody is a Rabbit Polyclonal against Sterol Carrier Protein 2. Target. Sterol Carrier Protein 2 ( ... Anti-Sterol carrier protein X, Anti-Sterol carrier protein X antibody, Sterol carrier protein X antibody, Antibody against ... NLTP, NSL-TP, SCPX, SCP-chi, Non-Specific Lipid-Transfer Protein, Propanoyl-CoA C-acyltransferase, Sterol carrier protein X, ...
The SCOP classification for the Biotinyl/lipoyl-carrier proteins and domains family. Additional information, provided for both ... Biotinyl/lipoyl-carrier proteins and domains family. SCOP classification Root: SCOP hierarchy in SUPERFAMILY [. 0] (11) ... Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain. ... that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919. ...
Riboflavin carrier protein which is obligatorily involved in yolk deposition of the vitamin in the chicken egg, is a unique ... Biochemical and immunological aspects of riboflavin carrier protein.. Authors: Adiga, P R. Visweswariah, S S. Karande, A. ... Using monoclonal antibodies to chicken riboflavin carrier protein, it could be shown that all the major epitopes of the avian ... Despite the fact that the carbohydrate composition of the yolk and white riboflavin carrier proteins differ presumably due to ...
We offer CRM197 carrier protein which is used to convert polysaccharides, glycans, peptides and other haptens into better ... CRM197 Carrier Protein. CRM197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate ... Carrier Proteins. Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent ... POSTER: NEW: EcoCRM - A Recombinant CRM197 Carrier Protein Download Now POSTER: EcoCRM: Economical Recombinant CRM197 Download ...
secretory carrier membrane protein 1 [Source:MGI S... [more]. Scamp1. 3.903e-56. 42.80. secretory carrier membrane protein 1 [ ... secretory carrier membrane protein 1 [Source:MGI S... [more]. Scamp3. 7.411e-52. 46.75. secretory carrier membrane protein 3 [ ... secretory carrier membrane protein 1 [Source:HGNC ... [more]. SCAMP3. 1.566e-56. 46.75. secretory carrier membrane protein 3 [ ... secretory carrier membrane protein 3 [Source:HGNC ... [more]. SCAMP1. 2.476e-56. 41.22. secretory carrier membrane protein 1 [ ...
GO:0140597: protein carrier activity (Molecular function). Binding to and carrying a protein between two different cellular ...
Recombinant Staphylococcus aureus Chemotaxis inhibitory protein (chp) from Cusabio. Cat Number: CSB-EP746696SKV. USA, UK & ... Recombinant Staphylococcus aureus Acyl carrier protein (acpP) , CSB-EP015636SKX Cusabio Staphylococcus aureus Recombinants ... Recombinant Staphylococcus aureus Acyl carrier protein (acpP) , CSB-EP015636SKX Cusabio Staphylococcus aureus Recombinants ... Recombinant Staphylococcus aureus Acyl carrier protein (acpP) , CSB-EP015636SKX , CusabioAlternative Name(s): hmrBGene Names: ...
Protein engineering and protein crystallography procedures and sample preparation for time-resolved X-ray spectroscopy. ... SO2: Preparation of next generation protein carriers for theranostic applications.. TO1: Training in protein engineering.. TO2 ... Dynamical studies of protein carriersunaltro2017-03-01T07:53:03+00:00 Dr Alessandra Bonamore Group - Molecular Links Rome srl ( ... Recombinant protein production and expression, random and site-selected mutagenesis, protein immobilization on activated ...
SPH1118 has been identified as a pectin-binding protein involved in both pectin chemotaxis and assimilation. Here we show ... Carrier Proteins / metabolism * Chemotaxis* * Crystallography, X-Ray * Models, Molecular * Pectins / metabolism * Protein ... Substrate size-dependent conformational changes of bacterial pectin-binding protein crucial for chemotaxis and assimilation Sci ... SPH1118 has been identified as a pectin-binding protein involved in both pectin chemotaxis and assimilation. Here we show ...
Carrier proteins and channel proteins are two types of membrane proteins. Here, we do an analysis of carrier proteins vs. ... channel proteins for a better understanding of the same. ... The proteins that facilitate the movement of molecules across a ... Carrier proteins and channel proteins are two types of membrane proteins. Here, we do an analysis of carrier proteins vs. ... Carrier proteins and channel proteins are two types of membrane proteins. Here, we do an analysis of carrier proteins vs. ...
Carrier proteins such as HSA or BSA are used to improve the stability of the reconstituted proteins, and help to avoid the ... Carrier proteins such as HSA or BSA are used to improve the stability of the reconstituted proteins, and help to avoid the ... Why are some proteins fused to tags? Do protein tags affect protein activity? ... Why are some proteins fused to tags? Do protein tags affect protein activity? ...
It is toxic and thus is not found free in living organisms but almost entirely sequestered by haem carrier proteins. We ... investigated the mechanisms of haem transfer between the proteins of a bacterial haem acquisition system involving haemophores ... It is toxic and thus is not found free in living organisms but almost entirely sequestered by haem carrier proteins. We ... Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is ...
AMPAR auxiliary proteins regulate receptor trafficking, and modulate receptor mobility and its biophysical properties. The ... AMPAR auxiliary protein Shisa7 (CKAMP59) has been shown to interact with AM … ... Carrier Proteins / genetics * Carrier Proteins / metabolism* * Gene Knockout Techniques * Hippocampus / physiology* * Membrane ... Keywords: Glutamate receptor; Shisa; auxiliary protein; long-term potentiation (LTP); mouse; neuroscience; protein interaction ...
... acyl carrier protein transacylase (fabd) by protein crystallography. Bacterial fatty acid synthes ... Kaufen sie legale anabole steroide Carrier protein A and dale ge (2006) mapping the active sites of escherichia coli malonyl- ... Carrier protein, steroide kaufen strafbar clenbuterol kaufen türkei - ... carrier-protein, trägerprotein englisch: carrier protein. Traductions en contexte de "carrier protein" en anglais- ...
Drug Delivery Carriers Targeted to Breast Tumor by Fusion Phage Proteins Petrenko, Valery A. Auburn University at Auburn, ... Drug Delivery Carriers Targeted to Breast Tumor by Fusion Phage Proteins. Petrenko, Valery A. / Auburn University at Auburn. $ ... Drug Delivery Carriers Targeted to Breast Tumor by Fusion Phage Proteins. Petrenko, Valery A. / Auburn University at Auburn. $ ... Drug Delivery Carriers Targeted to Breast Tumor by Fusion Phage Proteins. Petrenko, Valery A. / Auburn University at Auburn. $ ...
Subpollen particles: Carriers of allergenic proteins and oxidases. Journal of Allergy and Clinical Immunology. 2006 Oct;118(4): ... Subpollen particles : Carriers of allergenic proteins and oxidases. In: Journal of Allergy and Clinical Immunology. 2006 ; Vol ... Subpollen particles: Carriers of allergenic proteins and oxidases. Attila Bacsi, Barun K. Choudhury, Nilesh Dharajiya, Sanjiv ... Subpollen particles : Carriers of allergenic proteins and oxidases. / Bacsi, Attila; Choudhury, Barun K.; Dharajiya, Nilesh et ...
... acyl-carrier-protein] synthase (acpS) datasheet and description hight quality product and Backed by our Guarantee ... acyl-carrier-protein] synthase, holo-[acyl-carrier-protein] synthase. ... The protein can be with or without a His-Tag or other tag in accordance to customers request, Holo-[acyl-carrier-protein] ... Mycoplasma gallisepticum Holo-[acyl- -protein] synthase (acpS). Alternative name: Mycoplasma gallisepticum Holo-[acyl-carrier- ...
protein answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, ... carrier protein. 1. A protein that elicits an immune response when coupled with a hapten. 2. A membrane protein that helps a ... CHK2 protein. CHEK2 protein An abbreviation for a checkpoint kinase protein that stimulates cells to multiply and is found in ... membrane-bound protein. membrane protein A protein that is part of a cell membrane and acts as a receptor for substances ...
  • They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins. (
  • The selected landscape phages displaying breast cancer cell- Dinding peptides will be stripped and recombinant major coat protein pVIII will be introduced into the doxorubicin- or paclitaxel-loaded vesicles. (
  • 1E5M: Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp. (
  • Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp. (
  • beta-Ketoacyl-ACP synthases (KAS) are the condensing enzymes present in the fatty acid biosynthesis pathway and are able to elongate an acyl chain bound to either co-enzyme A (CoA) or acyl carrier protein (ACP) with a two-carbon unit derived from malonyl-ACP. (
  • The variation in the acyl-carrier (ACP or CoA) specificity might also be connected to this classification and residues involved in ACP binding in structure class 2 can be suggested based on the comparison. (
  • We want to find a single protein out all of these that is only expressed in skin cancers and not in healthy skin cells and it's found to be Malonyl CoA Acyl carrier protein transacylase , or MCAT for short. (
  • For detailed information about [acyl-carrier-protein] phosphodiesterase, go to the full flat file . (
  • L-glutamyl-[BtrI acyl-carrier protein] decarboxylase. (
  • Has very low activity with substrates not bound to an acyl-carrier protein. (
  • Acyl-acyl carrier protein (ACP) thioesterases (Fat) are essential components of the plant plastid-localized fatty acid synthase and determine the chain length of de novo synthesized fatty acids. (
  • Acyl-Carrier Protein S-Malonyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to generate malonyl-(acyl-carrier protein), which is an elongation substrate in FATTY ACIDS biosynthesis. (
  • This graph shows the total number of publications written about "Acyl-Carrier Protein S-Malonyltransferase" by people in this website by year, and whether "Acyl-Carrier Protein S-Malonyltransferase" was a major or minor topic of these publications. (
  • Below are the most recent publications written about "Acyl-Carrier Protein S-Malonyltransferase" by people in Profiles. (
  • A and dale ge (2006) mapping the active sites of escherichia coli malonyl-coa: acyl carrier protein transacylase (fabd) by protein crystallography. (
  • Bacterial fatty acid synthesis in escherichia coli is initiated by the condensation of an acetyl-coa with a malonyl-acyl carrier protein. (
  • Escherichia coli apo acyl carrier protein was chosen as a test case because of its high content of negatively charged carboxylates suitable for metal. (
  • Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A. J.Mol.Biol. (
  • Constitutive BiP protein accumulation in Arabidopsis mutants defective in a gene encoding chloroplast-resident stearoyl-acyl carrier protein desaturase. (
  • This study first clarified that the solute-binding protein with dual functions recognized the substrate through flexible conformational changes in response to the substrate size. (
  • These are membrane integral proteins (span across the membrane) and are highly specific in nature (one type of protein interacts with only one type of solute molecules). (
  • This binding of the solute molecules causes the protein to change its conformation to B, such that the binding site of the protein is now exposed on the other side of the membrane. (
  • The solute is then released from the carrier protein, and it returns to its original conformation A. (
  • Carrier proteins transfer solutes across the biological membrane by binding to the solute and alternate between two conformations. (
  • Channel proteins interact the least with the solute they transfer. (
  • Specificity of carrier proteins is due to the specific binding sites to which the solute molecules bind. (
  • The rate of transfer of solute by carrier proteins is about 10 4 ions per second. (
  • As the proteins do not flip from one conformation to the other, the rate of transfer of solute by channel proteins is much higher, i.e., 10 8 ions per second. (
  • This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. (
  • The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. (
  • This gene encodes a member of the solute carrier family 11 protein family. (
  • A related solute carrier family 11 protein gene is located on chromosome 2. (
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Solute Carrier Family 30, Member 1 (SLC30A1) in samples from tissue homogenates, cell lysates or other biological fluids. (
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 30, Member 1 (SLC30A1) in tissue homogenates, cell lysates and other biological fluids. (
  • The yolk and egg white proteins are products of a single estrogeninducible gene expressed in the liver and the oviduct respectively of egg laying birds. (
  • The ESR will be trained to gene design and protein engineering including expression and purification at Molirom's laboratory. (
  • A protein that stimulates the expression of a gene. (
  • The SLC46A1 gene provides instructions for making a protein called the proton-coupled folate transporter (PCFT). (
  • This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). (
  • Gene-nutrient interactions exemplified by the alpha-tocopherol content of tissues from alpha-tocopherol transfer protein-null mice fed different dietary vitamin E concentrations. (
  • Gene therapy involves the delivery of exogenous DNA into the target cells in order to produce therapeutic protein or to correct a genetic defect. (
  • The aim of this Master's thesis was to study non-viral gene delivery to RPE cells and endothelial cells using several carrier/DNA combinations. (
  • The carriers were complexed with episomal plasmid DNA or minicircles using secreted alkaline phosphatase (SEAP) gene as a marker gene. (
  • Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (
  • Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia. (
  • Thiamine-responsive megaloblastic anaemia (TRMA) is a syndrome associated with megaloblastic anaemia, diabetes mellitus and sensorineural deafness, due to mutations in the SLC19A2 gene, which codes for a thiamine carrier protein. (
  • Those with the trait are carriers, have no symptoms, but can pass the gene on to their offspring. (
  • The development of diagnostic and therapeutic nanodevices based on engineered recombinant proteins capable of recognizing specific tumor cell receptors is currently actively pursued. (
  • Specificity of channel proteins is due to an ion selectivity filter. (
  • Carrier protein specificity was also demonstrated. (
  • The proteins that facilitate the movement of molecules across a biological membrane are transport proteins. (
  • The function of carrier proteins is to transfer a large number of both polar and non-polar molecules across the semipermeable biological membrane. (
  • The function of channel proteins is to transfer water molecules and small polar molecules across the semipermeable biological membrane. (
  • Both proteins hasten the rate of transfer of molecules across the biological membranes. (
  • Carrier proteins may move molecules against concentration gradients in the presence. (
  • These contained Amb a 1, along with other allergenic proteins of ragweed pollen, and possessed nicotinamide adenine dinucleotide (reduced) or nicotinamide adenine dinucleotide phosphate (reduced) [NAD(P)H] oxidase activity. (
  • Clinical implications: Severe clinical symptoms associated with seasonal asthma might be explained by immune responses to inhaled SPPs carrying allergenic proteins and ROS-producing NAD(P)H oxidases. (
  • by allergenic proteins is less frequently reported since such lergen is presented to naive CD4+ T lymphocytes. (
  • Interplay between unfolded protein response and reactive oxygen species: a dynamic duo. (
  • Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions. (
  • We are offering custom peptide conjugation to carrier proteins for effective and successful anti-peptide antibody generation. (
  • As a result, the targeting probe?the tumor- specific peptide fused to the major coat protein?is exposed on the shell of the drug-loaded vesicle. (
  • A DNA sequence encoding the Homo sapiens (Human) Kidney mitochondrial carrier protein 1, was expressed in the hosts and tags indicated. (
  • rab5 GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • The new rules were established with the coordinated efforts of staff from MeSH, NCBI and scientists working in the field of HMG protein research. (
  • Genes involucrados en la amelogénesis imperfecta. (
  • involucrados en la AI no sindrómica, las proteínas codificas por estos genes y sus funciones, de acuerdo amelogénesis a la evidencia científica actual. (
  • Las futuras investigaciones abordadas desde la visión translacional ayudarán estética dental, a identificar nuevas mutaciones o nuevos genes, lo cual contribuirá a la evolución en la manera de clasificar, genes. (
  • Conjugation with a protein carrier improves the effectiveness of polysaccharide vaccines by inducing T-lymphocyte-dependent immunologic function ( 2 ). (
  • Conjugation of rhBMP-2 inhibited the free lateral diffusion and internalization of the activated complex of rhBMP-2 and the bone morphogenetic protein receptor. (
  • Hepatic excretory capacity is low both because of low concentrations of the binding protein ligandin in the hepatocytes and because of low activity of glucuronyl transferase, the enzyme responsible for binding bilirubin to glucuronic acid, thus making bilirubin water soluble (conjugation). (
  • We investigated the mechanisms of haem transfer between the proteins of a bacterial haem acquisition system involving haemophores. (
  • We propose a model of artificial juxtacrine signaling for the controlled release of recombinant human bone morphogenetic protein-2 (rhBMP-2) suitable for guided bone regeneration. (
  • Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects. (
  • Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20? (
  • Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. (
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (
  • Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. (
  • Binding to and carrying a protein between two different cellular locations by moving along with the target protein. (
  • SPH1118 has been identified as a pectin-binding protein involved in both pectin chemotaxis and assimilation. (
  • Bioselective binding properties of the phage protein-targeted drug carriers will be studied by optical, electron and fluorescent microscopy, flow cytometry and protein microarrays, and their cytotoxic effects on the target tumor cells will be evaluated in comparison with nontargeted drug-loaded vesicles using healthy cells as control. (
  • A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in transport from the cell membrane to early endosomes. (
  • This graph shows the total number of publications written about "rab5 GTP-Binding Proteins" by people in Harvard Catalyst Profiles by year, and whether "rab5 GTP-Binding Proteins" was a major or minor topic of these publication. (
  • Below are the most recent publications written about "rab5 GTP-Binding Proteins" by people in Profiles. (
  • This data will allow for analysis of the selected steroid hormones and related binding protein that can be used to assist in disease diagnosis, treatment, and prevention of diseases, such as Polycystic Ovary Syndrome (PCOS), androgen deficiency, certain cancers, and hormone imbalances. (
  • Inhibition of this response to erythropoietin by pertussis toxin suggests involvement of guanine nucleotide-binding regulatory proteins (G-proteins). (
  • Inhibition of the action of nonsuppressible insulin-like activity on isolated rat fat cells by binding to its carrier protein. (
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (
  • Binding to other proteins and erythrocytes also occurs, but the physiologic role is probably limited. (
  • The ESR will be trained to protein engineering and protein crystallography procedures and sample preparation for time-resolved X-ray spectroscopy. (
  • Protein crystallization will be carried out at UROM and preparation for Serial femtosecond crystallography experiments. (
  • Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. (
  • Adapter proteins participate in the immune response by acting as a bridge for enzymes in the signaling pathway needed to activate lymphocytes and initiate a response to an antigen. (
  • Violin plots show distribution of expression levels for Secretory carrier-associated membrane protein (SMED30008035) in cells (dots) of each of the 12 neoblast clusters. (
  • Expression of Secretory carrier-associated membrane protein (SMED30008035) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (
  • Main page main page membrane transport protein membrane protein ion molecule macromolecule protein biological membrane integral. (
  • ABBR: APP An integral membrane protein concentrated at neuron synapses that is cleaved biochemically into components, one of which is the Alzheimer disease-associated beta amyloid. (
  • and (2) The regulation and roles of fucokinase, fucosyltransferases and fucosylated target proteins in signaling networks, tumor progression, metastasis and immune evasion. (
  • Conclusions: The allergenic potency of SPPs released from ragweed pollen grains is mediated in tandem by ROS generated by intrinsic NAD(P)H oxidases and antigenic proteins. (
  • We propose a new approach which relies on the use of the stripped landscape phage?the composition of the phage coat proteins?as the targeting ligands of he drug-loaded liposomes and micelles. (
  • About 98% of estradiol is bound to transport proteins (SHBG and albumin). (
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (
  • A/G Ratio: The ratio of albumin to globulin (A/G ratio) is calculated from values obtained by direct measurement of total protein and albumin. (
  • More specific tests, such as albumin, liver enzyme tests, and serum protein electrophoresis must be performed to make an accurate diagnosis. (
  • Despite the fact that the carbohydrate composition of the yolk and white riboflavin carrier proteins differ presumably due to differential post-translational modification, the proteins are immunologically similar and have identical amino acid sequence (including a cluster of 8 phosphoser residues towards the C-terminus) except at the carboxy terminus where the yolk riboflavin carrier protein lacks 13 amino acids as a consequence of proteolytic cleavage during uptake by oocytes. (
  • The ABC2 uptake Superfamily includes proteins in TC families 2.A.87 (P-RFT) and 2.A.88 (VUT or ECF). (
  • The use of cationic liposomes and polymers as carriers of DNA is based on observations that positively charged carriers bind to anionic DNA protecting its premature degradation and facilitating its cellular uptake in transfection. (
  • In addition, DNA methyltransferase 3A (DNMT3A) activity is modulated by several regulatory proteins, including p53 and thymine DNA glycosylase (TDG). (
  • However, the relative role of histone tails and regulatory proteins in the simultaneous coordination of DNMT3A activity remains obscure. (
  • Proteins that bind to the double strand will tend to stabilize dsDNA, and melting will occur at higher forces. (
  • Proteins that bind to single stranded DNA (ssDNA) destabilize melting, provided that the rate of association is comparable to the pulling rate of the experiment. (
  • HBV demonstrates the ability to integrate and bind to p53 protein in the host DNA and propagate hepatocyte vulnerability through carcinogenic aflatoxin B1 (AFB1) damage. (
  • Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. (
  • Carriers in this study were DOTAP/DOPE/PS liposomes, methacrylamide based (PDMAEMA) micelles, and anionic lipid coated DNA complexes (LCDCs). (
  • Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together. (
  • A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. (
  • The mission of MoLiRom is focused on the development of advanced projects in the biosynthesis and production of protein based products including protein engineering based on random or site directed mutagenesis. (
  • Obligatory involvement of the mammalian riboflavin carrier protein in transplacental flavin transport to subserve fetal vitamin nutrition during gestation is revealed by experiments using pregnant rodent or subhuman primate models wherein immunoneutralisation of endogenous maternal riboflavin carrier protein results in fetal wastage followed by pregnancy termination due to selective yet drastic curtailment of vitamin efflux into the fetoplacental unit. (
  • Several non-mammalian organism-specific proteins classes have been added to accomodate the increasing need for indexing of proteins from model organisms. (
  • Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress. (
  • The role of G-proteins in regulation of the erythropoietin-modulated Ca 2+ channel was delineated here by microinjection of G-protein modulators or subunits into human erythroid precursors. (
  • Regulation of melanoma metastasis by ATF2-mediated control of protein fucosylation. (
  • Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. (
  • Recombinant protein production and expression, random and site-selected mutagenesis, protein immobilization on activated silicon surfaces. (
  • The AMPAR auxiliary protein Shisa7 (CKAMP59) has been shown to interact with AMPARs in artificial expression systems, but it is unknown whether Shisa7 has a functional role in glutamatergic synapses. (
  • Differential Expression of Rab5 and Rab7 Small GTPase Proteins in Placental Tissues From Pregnancies Affected by Maternal Coronavirus Disease 2019. (
  • The modification of carriers and the engineering of DNA are proposed to enable efficient and prolonged protein expression after transfection. (
  • Proteins that function in the transport of solutes across biological membranes are called membrane transport proteins. (
  • Nieng yan explores membrane transport proteins and the different mechanisms that cells have to exchange material with their environment. (
  • Light as a regulator: team of researchers demonstrates role of transport proteins in the synchronisation of circadian rhythms. (
  • On the basis of these results, we propose that GA distribution and activity in Arabidopsis is partly regulated by NPF3 acting as an influx carrier and that GA-ABA interaction may occur at the level of transport. (
  • To explain how GAs can pass through the plasma membrane as a part of cell-to-cell transport, the existence of active GA carriers has been proposed 22 . (
  • Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. (
  • Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. (
  • LDL-Cholesterol is a transport protein that carries cholesterol from the liver to the arteries, where it is ultimately deposited. (
  • HDL-Cholesterol is a transport protein, which carries cholesterol away from the vessel wall for removal from the body. (
  • There are now 50 new categories of transport proteins under Membrane Transport Proteins. (
  • In addition 34 headings that were formerly under Carrier Proteins, Membrane Proteins or Permeases are now arrayed under Membrane Transport Proteins. (
  • Many of the 2,018 Supplementary Concept Records (SCRs) that were formerly heading mapped to Carrier Proteins are now mapped to specific categories listed under membrane transport proteins. (
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (
  • Carrier proteins such as HSA or BSA are used to improve the stability of the reconstituted proteins, and help to avoid the product sticking to the walls of the vial. (
  • Bone morphogenic protein and its application in trauma cases: a current concept update. (
  • A glass polyalkenoate cement carrier for bone morphogenetic proteins. (
  • Background: Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (
  • The protein is highly conserved throughout evolution all the way to humans in terms of gross molecular characteristics such as molecular weight and isoelectric point, and in immunological properties, preferential affinity for free riboflavin and estrogen inducibility at the biosynthetic locus viz. (
  • Many of the organism-specific proteins listed in the SCR are now more clearly distinguished with organism names and HM to these protein classes. (
  • The rhBMP-2-conjugated scaffold prolonged stimulation of intracellular signal proteins in cells. (
  • These data directly demonstrate a physiologic function of G- proteins in hematopoietic cells and show that Giα2 is required in erythropoietin modulation of [Ca(i)] via influx through calcium channels. (
  • Our positively charged Ionized Magnesium attracts and joins with special carrier proteins that deliver this key nutrient to all our cells. (
  • Nanoparticles present in Moderna, Pfizer BioNTech, J&J, Astra-Zeneca and other non-US produced vaccines contain Graphene Oxide which enables Spiked Protein attachment to cell walls but more concerning it facilitates the Spiked Protein in crossing the blood / brain barrier where it is now able to enter Brain Cells. (
  • This was thought to only occur with HIV reverse-transcriptase disease (AIDS) but now demonstrated in normal cells aided by large quantities of like encoded protein strands e.g. (
  • Sickle-cell disease (SCD) is a genetic condition in which the red blood cells contain haemoglobin S (HbS), an abnormal form of the oxygen-carrying protein. (
  • Hast du also entsprechend viel SHBG relativiert sich dein hoher Testospiegel wieder, carrier protein. (
  • Western blotting and amino acid sequence analysis were used to examine the protein components of the SPP. (
  • A vegetarian diet can compensate for dietary protein deficiencies by combining vegetable groups that complement each other in their basic amino acid groups. (
  • These mutations cause the substitution of one protein building block (amino acid) for another amino acid in the PCFT protein, or result in a PCFT protein that is shorter than normal. (
  • This protein has the identical amino acid coding (sequence) found in Human DNA-Chromosome 8. (
  • Manufactures have not explained why this amino acid sequencing is contained in Spiked Protein formulation which was "purposed" to only trigger our Immune System response. (
  • Sterol Carrier Protein 2 Antibody is a Rabbit Polyclonal against Sterol Carrier Protein 2. (
  • Several isocyanate /protein conjugates were prepared using strain B6D2F1-mice concerning the induction of homocytotropic antibody suggested that the murine model of isocyanate induced homocytotropic antibody would be a convenient method of assessing the reliability and reproducibility of various isocyanate /protein reagents. (
  • Each injection contains approximately 50 billion of these spiked Proteins, nearly 100 times the number needed to elicit any antibody response. (
  • In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. (
  • High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from The 90+ Study. (
  • About 20 different amino acids make up human proteins, which may contain other minerals such as iron or copper. (
  • Thus has the potential to be a widely used carrier for both human and animal vaccines. (
  • Inquire the Recombinant Human POLR3H Protein by filling out the form below. (
  • proteins are part of all cell membranes. (
  • CRM 197 , a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidi s. (
  • Biological membranes contain an impermeable lipid bilayer with selectively permeable proteins embedded in it. (
  • They form a water-filled passage made of hydrophilic proteins that help in the transfer of ions and small polar solutes across the biological membrane. (
  • Carrier proteins transfer both polar and nonpolar solutes across the biological membrane. (
  • Channel proteins transfer only small and polar solutes across the biological membrane. (
  • A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. (