A measurement of the thickness of the carotid artery walls. It is measured by B-mode ULTRASONOGRAPHY and is used as a surrogate marker for ATHEROSCLEROSIS.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
The excision of the thickened, atheromatous tunica intima of a carotid artery.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
The main artery of the thigh, a continuation of the external iliac artery.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Lesions formed within the walls of ARTERIES.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
The vessels carrying blood away from the heart.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The nonstriated involuntary muscle tissue of blood vessels.
Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.
The main trunk of the systemic arteries.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Pathologic deposition of calcium salts in tissues.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

Recombinant human interleukin-10 inhibits proliferation of vascular smooth muscle cells stimulated by advanced glycation end products and neointima hyperplasia after carotid injury in the rat. (1/431)

The purposes of this study was to determine the effects of recombinant human interleukin-10 (rhIL-10) on proliferation of vascular smooth muscle cells (VSMCs) stimulated by advanced glycation end products (AGE) and neointima hyperplasia after rat carotid arterial injury. Rat aortic VSMCs were cultured and treated with rhIL-10 or AGE respectively, and then co-treated with rhIL-10 and AGE. Proliferation of VSMCs was quantified by colormetric assay. Cell cycle analysis was performed by flow cytomertry. Sprague-Dawley rats were treated with recombinant human IL-10 (rhIL-10) for 3 d after carotid arteries injury. The ratio of neointima to media area at the site of arterial injury was measured 28 d after balloon injury. The p44/42 MAPK activity was evaluated by the immunoblotting technique using anti-p44/42 phospho-MAPK antibody. Compared to control, AGE stimulated VSMCs proliferation. rhIL-10 alone had no effect on VSMCs growth. With AGE stimulation, rhIL-10, at dose as low as 10 ng/ml, inhibited VSMCs growth (P<0.05). The cell number in G(0)/G(1) phase of AGE and rhIL-10 co-treatment group was higher than that of AGE treatment alone (P<0.01) by flow cytometry analysis. Compared with the control group of neointima hyperplasia in rats, the ratio of neointima to media area of recombinant human IL-10 group was reduced by 45% (P<0.01). The p44/42 MAPK activity was significantly enhanced by AGE. The AGE effects were opposed by rhIL-10. The anti-inflammatory cytokine rhIL-10 inhibits AGE-induced VSMCs proliferation. Recombinant human IL-10 also inhibited neointima hyperplasia after carotid artery injury in rats. The results suggest the possibility that recombinant human IL-10, as a potential therapeutic approach, prevents neointimal hyperplasia.  (+info)

Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis. (2/431)

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Physical exercise, fitness and dietary pattern and their relationship with circadian blood pressure pattern, augmentation index and endothelial dysfunction biological markers: EVIDENT study protocol. (3/431)

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Medical decision-making system of ultrasound carotid artery intima-media thickness using neural networks. (4/431)

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The age correlation of the carotid intima-media thickness according to sex and side in asymptomatic subjects. (5/431)

PURPOSE: Reports concerning carotid intima-media thickness (CIMT) and linear correlation to age in healthy subjects did not distinguish the side and sex of the subjects. The purpose of this investigation attempts to clarify these issues. METHODS: 2402 asymptomatic persons, age 35-64, are separated into men's left (Lt) and right (Rt) and women's Lt and Rt carotid arteries for difference of CIMT between them and analysis of CIMT vs. age. RESULTS: There are significant difference between men's CIMT of Lt(CIMTML) vs Rt (CIMTMR), women's Lt(CIMTWL) vs. Rt (CIMTWR), Lt side CIMT of men vs women, and Rt side CIMT of men vs. women. The regression equation of CIMT vs. age for all four groups is determinated. CONCLUSION: We found an excellent linear correlation of CIMT to age and CIMT is significantly higher in men than women, so as higher in Lt than Rt. Further grouping of data into about 5-year period showed more clearly stepwise increasing of CIMT, so as the ratios of Lt CIMT different than Rt. CIMT study is served as highly efficient examination in therapy, prevention, clinic, or research survey about atherosclerosis and risk of stroke. Future study design concerning CIMT in separation groups of men and women, so as Lt and Rt is highly recommended.  (+info)

Atherogenic lipid profile and systolic blood pressure are associated with carotid artery intima-media thickness in children with Turner syndrome. (6/431)

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Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans. (7/431)

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Real-time co-registration using novel ultrasound technology: ex vivo validation and in vivo applications. (8/431)

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The triple line pattern on carotid intima media thickness imaging and its relationship to cardiovascular risk factors in patients on lipid lowering therapy Tania A Singh,1 Todd C Villines,2 Allen J Taylor31Division of Cardiology, Medstar Georgetown University Hospital, 2Walter Reed National Military Medical Center, Bethesda, MD, 3Georgetown University School of Medicine, Washington, DC, USA Background: Carotid intima media thickness (CIMT) infrequently identifies a triple line pattern (TLP) in the visualization of the internal elastic lamina. We examined the prevalence and predictors of the TLP among a consecutive series of subjects enrolled in a CIMT clinical trial, and also the effects of lipid lowering therapy.Methods: Baseline CIMT studies of subjects with known heart disease, or high risk for heart disease, were evaluated from a single site of the Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis trial (N
TY - JOUR. T1 - Carotid intima-media thickness among normoglycemia and normotension first-degree relatives of type 2 diabetes mellitus. AU - Purnamasari, Dyah. AU - Abdaly, Muhammad Syah. AU - Azizi, Mohamad Syahrir. AU - Wijaya, Ika Prasetya. AU - Nugroho, Pringgodigdo. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Introduction: Theoretically, first-degree relatives (FDRs) of type 2 diabetes mellitus (T2DM) are predisposed to have earlier and more severe atherosclerosis than non-FDR due to hereditary insulin resistance. A previous study reported that atherosclerotic plaques were found in 45.2% of young adults FDR of T2DM, but the study did not include non-FDR as control group. The aim of this study was to compare subclinical atherosclerosis (carotid intima-media thickness, CIMT) between FDR of T2DM and non-FDR. Method: This was a cross-sectional study involving 16 FDR subjects and 16 age-sex matched non-FDR subjects, aged 19-40 years, with normal glucose tolerance and no hypertension. Collected data ...
TY - CONF. T1 - Use of Carotid Intima-Media Thickness and Plaque Volume to Predict Single or Multi-vessel Coronary Artery Disease.. AU - Owen, Kathryn. AU - Menown, Ian. AU - McLaughlin, James. PY - 2020/12/15. Y1 - 2020/12/15. N2 - INTRODUCTION Increased carotid intima-media thickness (cIMT) has been extensively evaluated as a marker of cardiovascular risk. However, there are only limited data correlating cIMT and other carotid measurements with the presence and anatomical severity of coronary artery disease (CAD).PROBLEMCurrently, the two gold-standard methods for diagnosing CAD are Invasive Coronary Angiography (ICA) and Computed Tomography Coronary Angiography(CTCA). With over 250,000 ICAs and 42, 340 CTCAs performed in the UK each year, at a cost of £2500 and £500 retrospectively, this is an enormous cost to the health service. ICA and CTCA both require radiation and in the case of the former, a day in hospital. Of those undergoing diagnostic angiograms, almost two-thirds do not have ...
TY - CONF. T1 - Use of Carotid Intima-Media Thickness and Plaque Volume to Predict Single or Multi-vessel Coronary Artery Disease.. AU - Owen, Kathryn. AU - Menown, Ian. AU - McLaughlin, James. PY - 2020/12/15. Y1 - 2020/12/15. N2 - INTRODUCTION Increased carotid intima-media thickness (cIMT) has been extensively evaluated as a marker of cardiovascular risk. However, there are only limited data correlating cIMT and other carotid measurements with the presence and anatomical severity of coronary artery disease (CAD).PROBLEMCurrently, the two gold-standard methods for diagnosing CAD are Invasive Coronary Angiography (ICA) and Computed Tomography Coronary Angiography(CTCA). With over 250,000 ICAs and 42, 340 CTCAs performed in the UK each year, at a cost of £2500 and £500 retrospectively, this is an enormous cost to the health service. ICA and CTCA both require radiation and in the case of the former, a day in hospital. Of those undergoing diagnostic angiograms, almost two-thirds do not have ...
Vascular morbidity and mortality due to cardiovascular disease (CVD) are high after ischemic stroke at a young age. Data on carotid intima-media thickness (cIMT) as marker of atherosclerosis are scarce for young stroke populations. In this prospective case-control study, we examined cIMT, the burden of vascular risk factors (RF) and their associations among young and middle-aged ischemic stroke patients and controls. We aimed to detect clinical and sub-clinical arterial disease. This study was conducted in 150 patients aged 15-60 years and 84 controls free of CVD. We related RF to ultrasonographic B-mode cIMT-measurements obtained from 12 standardized multiangle measurements in the common carotid artery (CCA), carotid bifurcation (BIF) and internal carotid artery (ICA). RF burden was higher among patients than among controls (p | 0.001). In multivariate analyses of all 234 participants, increased cIMT was associated with age in each carotid segment. Incident stroke was associated with increased ICA-IMT.
BACKGROUND: Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. METHODS AND RESULTS: To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables considering the whole carotid tree (IMT(mean), IMT(max), and IMT(mean-max)), were analyzed. A replication stage investigating 42 single-nucleotide polymorphisms for association with common carotid IMT was undertaken in 5 independent European cohorts (total n=11,590). A locus on chromosome 16 (lead single-nucleotide
Carotid intima-media thickness (CIMT) is associated with an increased risk of cardiovascular disease. We studied whether CIMT predicts the prognosis of Asian patients with acute ST-elevation myocardial infarction (STEMI). A total of 345 patien
TY - JOUR. T1 - Growth of Carotid Intima-Media Thickness in Black and White Young Adults. AU - Hao, Guang. AU - Wang, Xiaoling. AU - Treiber, Frank A.. AU - Davis, Harry. AU - Leverett, Sharika. AU - Su, Shaoyong. AU - Kapuku, Gaston. PY - 2016/12. Y1 - 2016/12. N2 - Background--There are few longitudinal studies that have comprehensively examined the intima-media thickness (IMT) growth pattern and its determinants among racial population groups. Methods and Results--Mean and maximum IMT were measured by B-mode ultrasonography up to 3 times in 253 white and 268 black participants, aged 13 to 36 years (mean age±standard deviation 24±3.2 years old). The development of IMT was assessed using individual growth curve modeling. A total of 521 participants with 1015 IMT measurements were eligible for this study. We found higher IMT in both left and right sides in blacks compared to whites (P,0.001) in young adulthood. Both whites and blacks showed a strong linear increase in mean IMT with age. Body ...
Association of Carotid Intima Media Thickness and Periscope Markers with Coronary Artery Disease, Risk factors and Biomarkers in Asian Indians Surrogate sub clinical mar..
Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media thickne
To the Editor:. We congratulate Lorenz et al1 on their review of carotid intima-media thickness (IMT). The authors acknowledged that the heterogeneity among IMT measurement methodologies and study populations are the most important limitation of their metaanalysis. It is surprising however that the paper lacks discussion regarding the prognostic importance of the presence of carotid plaque. Moreover, no information was provided on plaque prevalence or on the effect that incorporation of plaque into IMT measurements likely had on the results.. Carotid plaque is a distinctive phenotype of atherosclerosis that poses a higher likelihood of rupture, thrombosis, rapid progression, responds to factors that affect endothelial function, and represents remodeling to minimize flow disturbances.2 In contrast, IMT principally represents hypertensive hypertrophy of the media and is under a substantial genetic control different from that of plaque.2 Carotid plaque most likely is not a simple continuum of IMT ...
OBJECTIVE: Carotid intima-media thickness (cIMT) is a surrogate marker of subclinical atherosclerosis and it is able to predict both coronary and cerebral vascular events. No data exist on the association between cIMT and non valvular atrial fibrillation (NVAF) type. We conduct this study with the aim to analyze the association between abnormal cIMT and NVAF type. METHODS: A cross-sectional study of the Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) has been performed. Among 2027 patients enrolled in the ARAPACIS, 673 patients, who underwent carotid ultrasound examination to assess cIMT, were included in the study. RESULTS: Among the entire population, 478 patients (71%) had cIMT , 0.90 mm. Patients with an abnormal cIMT (,0.90 mm) were significantly older and more likely hypertensive, diabetic and with a previous history of stroke than those with normal cIMT (≤0.90 mm). These patients had more permanent/persistent NVAF and ...
Based on sample participants and measurement protocols, we assessed the reliability of CIMT and plaque presence between three clinical centers. We regarded an ICC in the range 0.4-0.75 as fair to good and , 0.75 as excellent [21]. In our results, the mean CIMT values had an excellent range of ICC, while the maximum CIMT values had a fair to good range. It is probably because the mean CIMT value is less affected by an outlier than the maximum value. We attribute these results to our protocol that allows adding the plaque thickness to CIMT if plaque exists in distal CCA. This tendency was consistent with the results from other articles [14,17]. Spearman correlation showed similar tendency, too. We could not conclude the rating of each center due to the lack of absolute right CIMT value, but from these results, center 3 was likely to provide a highly reliable value. In the separate analysis done by right and left carotid arteries, only the mean CIMT value of right carotid artery had an ...
Background and aims: Previous studies have documented environmental risk factors for the progression of carotid intima-media thickness (IMT); however, few have examined genetic risk factors for the progression of carotid IMT and none has specifically examined subjects with type 2 diabetes. This study examined the association between single nucleotide polymorphisms in the adiponectin gene and the progression of carotid IMT in patients with type 2 diabetes.. Materials and methods: We performed common carotid ultrasonography at baseline and 33 39 months later in 324 consecutive subjects with type 2 diabetes. The genotypes of the adiponectin gene were determined using a single base primer extension method.. Results: The A allele of −11426A/G (P,0.05), G allele of −10066C/G (P=0.001), A allele of −8564G/A (P,0.01), A allele of −450A/G (P,0.05), and G allele of 276G/T (P,0.01) were associated with progressive carotid IMT. In the haplotype analysis, the AC/AC haplotype combination in block 1, ...
Introduction: HDL-cholesterol (HDL-c) is a strong, traditional negative cardiovascular (CV) risk factor. However, some reports suggest that extremely elevated HDL-c, i.e. hyperalphalipoproteinemia (HALP), may mark dysfunctional HDL particles, paradoxically conferring increased CV risk. Moreover, therapies aimed to increase HDL-c levels through CETP inhibition failed to demonstrate CV risk reduction despite substantial increase in HDL-c. Carotid Intima-Media Thickness (cIMT) is a reliable surrogate for atherosclerotic disease, validated for CV risk assessment. We studied cIMT among individuals with HALP.. Hypothesis: We assessed the hypothesis that HALP is independently associated with lower cIMT when compared with HDL-c levels on usual normal range.. Methods: The Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) enrolled 15,105 subjects aged 35-74 years between 2008-10 for long-term follow-up, which included IMT measurements in both common carotid arteries and assessment of lipid ...
Introduction: Increased Carotid intima-media thickness (CIMT) has been shown to be predictive of future cardiovascular events in middle-age and older adults, with this outcome being detrimentally enhanced by increased body adiposity -as measured by Body Mass Index (BMI).. Hypothesis: We assessed the hypothesis that the association between BMI and CIMT varies among race (black/white) and gender groups.. Methods: B-mode ultrasound images of the far walls for both carotid arteries were obtained from 676 community-based subjects, aged 24 to 43 years, enrolled in the Bogalusa Heart Study (70% white and 43% male). CIMT, BMI and traditional cardio metabolic (CM) risk factors were measured at baseline, and a second set of CIMT imaging was performed at follow-up after an average of 6.9 years. Composite CIMT was considered for the analyses. Progression of IMT was defined as an increase of IMT between examinations, that was greater than the upper endpoint of the 95% confidence interval of the mean ...
Hypertension and arterial vasculopathy may be mutual causes and effects. It is unknown whether carotid intima-media thickness (cIMT) is reliably predictive of the presence of newly developed hypertension in the Chinese population. This study evaluated the impacts of cIMT on new-onset hypertension in a community-based population without hypertension at baseline in China. A total of 672 Chinese subjects who had complete data for demographics, baseline and follow-up blood pressure measurements, and cIMT measurements at baseline were included in our study. Baseline cIMT was obtained under standardized procedures using the GE Vivid 7 ultrasound system equipped with an 8-MHz linear array vascular probe (GE Medical Systems, Milwaukee, Wl, USA). The outcome was the incidence of hypertension at follow-up. Multivariate regression models were used to access the association between baseline cIMT and the risk of new-onset hypertension. Subjects were 51.5 ± 4.7 years old, and 32.0% were male. The mean baseline
BACKGROUND: Lower socioeconomic position (SEP) predicts higher cardiovascular risk in adults. Few studies differentiate between neighborhood and family SEP or have repeated measures through childhood, which would inform understanding of potential mechanisms and the timing of interventions. We investigated whether neighborhood and family SEP, measured biennially from ages 0 to 1 year onward, was associated with carotid intima-media thickness (IMT) at ages 11 to 12 years. METHODS AND RESULTS: Data were obtained from 1477 families participating in the Child Health CheckPoint study, nested within the Longitudinal Study of Australian Children. Disadvantaged family and neighborhood SEP was cross-sectionally associated with thicker maximum carotid IMT in separate univariable linear regression models. Associations with family SEP were not attenuated in multivariable analyses, and associations with neighborhood SEP were attenuated only in models adjusted for family SEP. The difference in maximum carotid ...
The renin-angiotensin-aldosterone system can be activated by sympathetic nervous input and is thought to have an important role in the prevalence of hypertension and cardiovascular risk in black Africans. We examined (1) the association between plasma renin responses to mental stress and a marker of sub-clinical atherosclerosis; and (2) associations between resting renin and 24-h ambulatory blood pressure. Participants were 143 urbanized black African men and women (43.1±7.7 years) drawn from a study of Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA). After an overnight fast, participants completed the Stroop mental stress task. Blood samples were drawn during baseline and 10 min after the task to assess the concentration of active renin in plasma. Blood pressure assessments included continuous Finometer measures during the stress testing and 24-h ambulatory monitoring. Carotid intima-media thickness (CIMT) was measured using high-resolution ultrasound. Approximately 50% ...
Carotid intima-media thickness (IMT) is a measure of arterial thickening and a risk predictor for myocardial infarction and stroke. It is unclear whether IMT also predicts atrial fibrillation (AF). We explored the association between IMT and incidence of first AF hospitalization in a population-based cohort ...
A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque buildup in the arteries supplying blood to the head. Learn more.
Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or ...
Comparison of the effect on the progression of the carotid intima-media interphase thickness (GIM), arterial rigidity according to the measurement of the pulse wave speed and direct measurement of the carotid and aortic rigidities and an inflammation marker (PCR) in patients with established cardiovascular disease (myocardial infarct, atherosclerotic coronary disease), diabetes mellitus type 2 or equivalent risk of coronary disease and a low density lipoprotein level , 100 mg/dL, treated with simvastatin, pravastatin or the combination of simvastatin-ezetimibe during a period of at least one year ...
Background: The most common cause of mortality in people with diabetes is cardiovascular disease. The relation between glycosylated hemoglobin (HbA1c), a marker of glycemic control, and the development of subclinical atherosclerosis is debated. An acceptable indicator of subclinical atherosclerosis is the use of ultrasound to measure carotid intima-media thickness (CIMT). Objective: To conduct a cross-sectional study exploring the correlation between HbA1c and subclinical atherosclerosis as reflected by the carotid intima-media thickness in patients with type 2 diabetes that had no history of an atherosclerotic cardiovascular disease (ischemic heart disease or cerebrovascular accident). Methods: A total of 71, type 2 diabetic patients participated in this study. Demographic, anthropometric and laboratory measures of the participants were collected. CIMT values were measured by using a high-resolution ultrasound. Increased CIMT values were accepted as |0.9 mm. Participants were categorized into two
Methods and Results: To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables considering the whole carotid tree (IMTmean, IMTmax, and IMTmean-max), were analyzed. A replication stage investigating 42 single-nucleotide polymorphisms for association with common carotid IMT was undertaken in 5 independent European cohorts (total n=11 590). A locus on chromosome 16 (lead single-nucleotide polymorphism rs4888378, intronic in CFDP1) was associated with cIMT at significance levels passing multiple testing correction at both stages (array-wide significant discovery P=6.75×10 -7 for ...
In this study, we identified and replicated TRAF1 (lead SNP rs2416804) on chromosome 9 to be linked and associated with CIMT (pooled P=6.02×10-7). We additionally identified 2 genomic regions on chromosomes 4 and 17 with suggestive linkage to CIMT, which have not been reported before. Finally, we could replicate previously reported linkage findings on chromosomes 13 and 14.. Our combined linkage and association analysis identified a SNP in TRAF1 on chromosome 9, as well as a cluster of SNPs on chromosome 6. TRAF proteins mediate the signal transduction from receptors of the tumor necrosis factor receptor and were detected in plaques from atherosclerotic lesions.31 A genome-wide association study and a candidate gene study identified TRAF1 as susceptibility genes for rheumatoid arthritis (RA).32,33 RA is associated with increased mortality, largely as a consequence of coronary artery disease. It was, thus, hypothesized that inflammation associated with RA contributes to accelerated ...
Moon et al conducted a 5-year cohort study to know the association between carotid atherosclerosis and progression of cognitive impairment in 348 older adults.1 Cognitive function was assessed using standard test batteries, and carotid atherosclerosis was determined by ultrasonographic measurement of intima-media thickness (IMT) and plaque formation in the carotid artery. The authors adopted multivariate logistic regression analyses for predicting the progress of cognitive impairment or mild cognitive impairment by adjusting age, education, mood, and general health status. Odds ratio (95% confidence interval) of baseline mean carotid IMT for subsequent progression of cognitive impairment and mild cognitive impairment in subjects with normal baseline cognition were 1.251 (1.006-1.555) and 1.325 (1.045-1.679), respectively. In contrast, carotid plaque did not significantly contribute to cognitive impairment after full adjustment. I have some queries on their study.. First, the authors handled ...
Our study showed that in our sample, patients with type 1 diabetes had a higher IMT compared with the control subjects. Despite having type 1 diabetes for a relatively long time, our patients with type 1 diabetes had a lower IMT than expected, similar to the findings of another study [13]. In our study, in patients with type 1 diabetes, having a family history of type 2 diabetes was associated with a 4.4% increase in carotid IMT and unlike the control group, women with type 1 diabetes had a IMT as high as men.. In the control group, the female gender was associated with a thinner IMT, but this association was not found in our patients with type 1 diabetes. A study that evaluated the distribution of IMT according to age in the general population showed that men had a higher IMT compared with women [39]. These findings could reflect a loss of gender protection for CVD risk in women with type 1 diabetes as suggested by The Diabetes UK Cohort Study and another study [40, 41]. In fact, in patients ...
Background: Type 2 diabetes is a common disease with increased mortality and morbidity due to cardiovascular disease (CVD). This thesis is based on three studies that evaluated traditionally used and emerging risk markers to identify individuals with high-risk of developing CVD in middle-aged men and women with type 2 diabetes. One study was conducted to compare the equivalence between two different ultrasound techniques to measure intima-media thickness since IMT was used to evaluate subclinical atherosclerosis as a surrogate endpoint.. Methods: Data from the cohort study, cardiovascular risk in type 2 diabetes - a prospective study in primary care (CARDIPP) was used in paper I, III and IV. In paper I, baseline data from the first 247 subjects was analysed. Associations between traditionally measured lipids, apolipoproteins, glycaemic control and low-grade inflammation and IMT were analysed.. In paper III, the full baseline cohort, with data from 761 subjects from the CARDIPP study was ...
Our findings suggest endothelial injury in obese children. Intima-media thickness and vWF level might be useful to identify the degree of endothelial damage.
We have used carotid IMT rather than CHD as our outcome. Carotid IMT has been shown to be strongly associated with prevalent and incident CHD.13,18 It has been suggested that the difference in IMT between women and men may be explained by differences in luminal diameter.22 However, this has been shown not to be the case in the large Tromso study.14 There was a differential in the response between women and men in our study and a difference in the nature of the sampling frame for women and men. Men were survivors of a prospective cohort, whereas women were a newly selected random sample. While among the men responders did not appear to differ from non-responders with respect to age, women who responded were younger than those who did not and women were on average slightly younger than men in the final study sample. All results presented in this study are adjusted for age. Mean blood pressure, lipid levels, and waist-hip ratios for both women and men from this study are similar to those for ...
Results A total of 76 patients were screened and 22 RA patients who were in low disease activity or remission were included. Patients with RA had significantly higher median cIMT, 0.53 (IQR0.13) mm compared to controls, 0.47 (IQR 0.14) mm, p=0.01. In RA patients, the cIMT had significant positive correlation with age (rs=0.84, p=0.00), systolic BP (rs=0.45, p=0.04), waist circumference (rs=0.43, p=0.04), total cholesterol (rs=0.54, p=0.01), BMI (rs=0.45, p=0.04) and serum IL-17 (rs=0.45, p=0.03) but negative correlation with total HDL (rs=-0.43, p=0.05). ...
Methods. The study population included 58 patients undergoing percutaneous coronary intervention (PCI) with stenting and at least 10 months of follow-up. All patients underwent ultrasound detection of brachial artery reactivity 30 days after PCI. Flow mediated dilatation (FMD) was investigated after 5 minutes of occlusion of the artery and nitroglycerin mediated dilation (NMD) was investigated after administration of sublingual nitrates. Vascular echography was performed to measure intima media thickness (IMT) of carotid arteries. At baseline we evaluated all the established traditional cardiovascular risk factors. We also subdivided our study cohort according to values of FMD in patients with FMD above and patients below the median value ...
Bronner Handwerger, ND. Assessing cardiovascular risk factors is always part of the naturopathic intake. The question arises as to how we assess these risks. We recognize that traditional markers like cholesterol, HDL, LDL, Lp(a), fibrinogen, homocysteine and even cardio CRP provide us with valuable information, along with family history. Although these are important to assess, they still do not give us the kind of reliable information we are looking for.. Cardiovascular disease is the No. 1 killer in the U.S. for both men and women. Heart disease and stroke account for almost six million hospitalizations each year, and more than 40% of all people age 45 and older have some form of cardiovascular disease. Approximately 1.1 million Americans are expected to have a new or recurrent heart attack this year, and 60% of all deaths in the U.S. are attributed to cardiovascular disease. A more sobering statistic is that 40%-50% of all heart attack patients have a normal cholesterol or lipid profile, ...
Results The groups were similar in age and gender. The biomass fuel group had greater unadjusted mean CIMT (0.66 vs 0.60 mm; p,0.001), carotid plaque prevalence (26% vs 14%; p=0.03), systolic blood pressure (118 vs 111 mm Hg; p,0.001) and median household PM2.5 (280 vs 14 µg/m3; p,0.001). In multivariable regression, the biomass fuel group had greater mean CIMT (mean difference=0.03 mm, 95% CI 0.01 to 0.06; p=0.02), a higher prevalence of carotid plaques (OR=2.6, 95% CI 1.1 to 6.0; p=0.03) and higher systolic blood pressure (mean difference=9.2 mm Hg, 95% CI 5.4 to 13.0; p,0.001).. ...
Methods: 48-wk prospective cohort study to compare changes in IMT and inflammation markers in ART-naïve HIV+ adults and age, sex and race-matched healthy controls. Diabetes and cardiovascular disease (CVD) were exclusionary. ANCOVA was used to adjust means. Correlation coefficients and multivariable linear regression were used to explore relationships between baseline and change in IMT and inflammation markers ...
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TY - JOUR. T1 - Machine learning to predict rapid progression of carotid atherosclerosis in patients with impaired glucose tolerance. AU - Hu, Xia. AU - Reaven, Peter D.. AU - Saremi, Aramesh. AU - Liu, Ninghao. AU - Abbasi, Mohammad Ali. AU - Liu, Huan. AU - Migrino, Raymond Q.. AU - the ACT NOW Study Investigators, ACT NOW Study Investigators. PY - 2016/12/1. Y1 - 2016/12/1. N2 - Objectives: Prediabetes is a major epidemic and is associated with adverse cardio-cerebrovascular outcomes. Early identification of patients who will develop rapid progression of atherosclerosis could be beneficial for improved risk stratification. In this paper, we investigate important factors impacting the prediction, using several machine learning methods, of rapid progression of carotid intima-media thickness in impaired glucose tolerance (IGT) participants. Methods: In the Actos Now for Prevention of Diabetes (ACT NOW) study, 382 participants with IGT underwent carotid intima-media thickness (CIMT) ultrasound ...
1 Maier H. Präparierkurs Präparieranweisungen und Theorie. 2., erw. Aufl. Köln: Deutscher Ärzte-Verlag; 1987. 2 Faxon DP, Creager MA, Smith SC Jr, Pasternak RC, Olin JW, Bettmann MA, et al. Atherosclerotic Vascular Disease Conference: executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association. Circulation. 2004;109(21):2595-604. 3 Ross R, Faggiotto A, Bowen-Pope D, Raines E. The role of endothelial injury and platelet and macrophage interactions in atherosclerosis. Circulation. 1984;70(5 Pt 2):III77-82. 4 Gossl M, Lerman LO, Lerman A. Frontiers in nephrology: early atherosclerosis - a view beyond the lumen. J Am Soc Nephrol. 2007;18(11):2836-242. 5 Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med. 2011;17(11):1410-22. 6 Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685-95. 7 Hegele RA. The ...
TY - JOUR. T1 - Measurements of Intima-Media Thickness in Chinese Patients with Carotid or Aortic Plaque can Not Exclude Significant Coronary Stenosis. AU - Lin, Mei Shu. AU - Hong, Chi Tzong. AU - Chang, Nen-Chung. PY - 2008/6. Y1 - 2008/6. KW - Chinese. KW - Coronary artery disease. KW - Aorta. KW - Carotid artery. KW - Atherosclerotic plaque. KW - Intima-media thickness UR - http://readopac1.ncl.edu.tw/nclJournal/search/detail.jsp?sysId=0006563928&dtdId=000040&search_type=detail&la=ch%20?iframe=true. M3 - Article. VL - 2. SP - 32. EP - 45. JO - 臺灣心臟超音波學會雜誌. JF - 臺灣心臟超音波學會雜誌. IS - 2. ER - ...
OBJECTIVE: Increased arterial stiffness and carotid intima-media thickness (IMT) are considered independent predictors of cardiovascular events. The aim of this study was to compare a system recently developed in our laboratory for automatic assessment of these parameters from ultrasound image sequences to a reference radio frequency (RF) echo-tracking system. METHODS: Common carotid artery scans of 21 patients with cardiovascular risk factors and 12 healthy volunteers were analyzed by both devices for the assessment of diameter (D), IMT, and distension (DeltaD). In the healthy volunteers, analyses were repeated twice to evaluate intraobserver variability. Agreement was evaluated by Bland-Altman analysis, whereas reproducibility was expressed as a coefficient of variation (CV). RESULTS: Regarding the agreement between the two systems, bias values +/- SD were 0.060 +/- 0.110 mm for D, -0.006 +/- 0.039 mm for IMT, and -0.016 +/- 0.039 mm for DeltaD. Intraobserver CVs were 2% +/- 2% for D, 5% +/- ...
At baseline, 783 patients were recruited for the evaluation. During the follow-up period (5.46 ± 0.39 years), 50 coronary events and 35 strokes were recorded. These patients were older and had higher systolic and diastolic BP, higher baPWV, higher IMT, and higher FRS, compared with those without such events. CVD occurred more frequently in men than in women.. The Kaplan-Meier curves showed lower event-free rates with higher IMT (using the fourth quintile of IMT as the cutoff value; log-rank χ2 = 8.87; P = 0.03), baPWV (using the fourth quintile of baPWV as the cutoff value; log-rank χ2 = 9.83; P = 0.02), and Framingham score (FRS ≤10%, FRS ,10% but ≤20%, FRS ,20%; log-rank χ2 = 23.1; P , 0.001).. Next, we examined the ability to predict CVD at ∼5 years by evaluating ROC. The areas under the ROC curves for IMT and baPWV were similar (0.590 and 0.583, respectively), although that for FRS was modestly higher (0.645). Simple addition of both IMT and baPWV to FRS results in only a modest ...
Results: The level of glycosylated hemoglobin and CIMT progressively increased across quintiles of IGP (P for trend = 0.01 for both). In univariate analysis, all examined glycemic parameters were significantly correlated with CIMT. IGP (r = 0.40; P = 0.006) showed the strongest correlation with CIMT, which remained significant in multiple linear regression analysis (R-2 = 0.26; P = 0.01). IGP was associated with a significant increase of CIMT in tertiles of glycosylated hemoglobin. IGP occurred within 1 h from the start of the meal in 95% of the entire diabetic population ...
Results For CIMT≥1.38 mm (≥3rd quartile), the sensitivity and specificity of ≥3-territory involvement were 90.0% and 82.6%. MA≥6.85 mg/dl (≥3rd quartile), the sensitivity and specificity of ≥2-territory involvement were 54.9% and 83.3%. CV events occurred in 104 subjects. The Kaplan-Meier 2-year CV event-free survival was 93.9% and 95.7%; 95.7% and 89.6%; 73.9% and 72.3%; 59.6% and 66% in patients with mean-CIMT and MA values in the 1st; 2nd; 3rd and 4th quartile. The multivariable Cox proportional hazard model identified: mean-CIMT ≥1.38 mm (RR=1.83; CI 1.049 to 3.196; p,0.001), MA≥6.84 mg/dl (RR=0.99; CI 0.576 to 1.703; p,0.001). Inclusion of CIMT into the stratification model significantly improved the prediction of CV event risk (Δχ2=7.098, p,0.001) whereas the impact of the MA is not significant (△χ2=0.002, p,0.001).. ...
Numerous studies over the past 2 decades have demonstrated the benefit of low-density lipoprotein (LDL) cholesterol lowering on heart attack, stroke, and cardiac death (1). Both invasive and noninvasive imaging approaches have been used as surrogate markers to demonstrate benefits of LDL lowering on atherosclerosis. Studies using intravascular ultrasonography (IVUS) of the coronary arteries have demonstrated that statin initiation is associated with halting of plaque progression, and, in fact, with more potent statins, evidence of plaque regression (2). Carotid intima-media thickness studies with ultrasonography have likewise demonstrated benefit of statin therapy (3). These studies have primarily been conducted over the first year or 2 after initiation of statins, and the endpoint used has been coronary plaque volume or greatest plaque area in the case of IVUS and carotid wall thickness in the case of carotid intima-media thickness. Noninvasive imaging with magnetic resonance imaging (MRI) of ...
IGPs are frequent in the everyday life of patients with type 2 diabetes, occur for most (95%) within 1 h after meal, timing of IGPs is not influenced by treatment (diet or drugs), and IGPs correlate with CIMT.
TY - JOUR. T1 - Association of pathobiologic determinants of atherosclerosis in youth risk score and carotid artery intima-media thickness in asymptomatic young heterozygous familial hypercholesterolemia patients. AU - Cheng, Hao Ming. AU - Ye, Zhong Xuan. AU - Charng, Min Ji. PY - 2011/9. Y1 - 2011/9. N2 - Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by extremely high cholesterol level, accelerated atherosclerosis and premature cardiovascular disease.We need an early risk stratification method for this population. Arisk score formula to estimate the probability of advanced atherosclerosis using coronary heart disease risk factors was developed for persons 15-34 years of age by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. This studys aim was to investigate the relation between PDAY risk score and carotid intima-media thickness (IMT) and inflammation markers in asymptomatic young FH subjects. Methods: We included 23 ...
Background Hypertension, identifiable by elevated blood pressure (BP), is a heterogeneous multifactorial disorder. Epicardial adipose tissue (EAT), a special fat depot that is related to visceral fat rather than total adiposity, shares the same microcirculation with myocardial tissue and coronary vessels. Recent studies have identified EAT as an active organ, which secretes several mediators, called adipokines, affecting the vascular system. The aim of this study was to evaluate the potential association between EAT and BP, endothelial function, carotid intima-media thickness (CIMT), and pulse wave velocity (PWV) independent of conventional and novel metabolic risk factors in patients with previously untreated hypertension. ...
We have reported that psoriatic arthritis (PsA) patients without overt cardiovascular diseases have evidence of premature atherosclerosis as indicated by an increased carotid intima-media thickness (IMT).1 Whether an increase in IMT reflects current (but reversible) inflammation of the vessel wall rather than more permanent structural vessel changes in PsA has never been assessed. We undertook a prospective, observational study to determine whether a 12-week treatment of tumour necrosis factor alpha (TNFα) blockers may reduce IMT in patients with active PsA, and whether the changes in IMT can be sustained in patients who were continued on long-term TNFα blockers.. Twenty consecutive PsA patients with active disease were recruited to receive TNFα blockers. After 12 weeks, nine patients continued (group 1) while 11 patients discontinued TNFα blockers due to financial constraints (group 2). Twenty PsA patients who were naive to TNFα blockers were recruited as controls (group 3). Patients … ...
Fingerprint Dive into the research topics of Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis. Together they form a unique fingerprint. ...
In the present analysis, we observed no additional value of measurement of mean common CIMT in risk classification among 17 254 individuals free from symptomatic CVD, but with elevated blood pressure levels. For those at intermediate risk, the addition of common CIMT to an existing cardiovascular risk score is small but statistically significant. However, the decision on whether or not to implement common CIMT measurements in individuals with elevated blood pressure levels at intermediate risk depends on the balance between costs of additional risk assessment by CIMT measurements and effectiveness in preventing CVD.. In asymptomatic individuals with elevated blood pressure, guidelines recommend cardiovascular risk assessment and suggest screening for subclinical vascular damage.1,5-7 It has been suggested that providing a more accurate assessment of vascular damage related to hypertension may lead to a more precise stratification of CVD risk.20 As such, the 2007 ESH/ESC hypertension guidelines ...
This study shows that spironolactone prevents the progression of carotid CIMT in HD patients. The protective effect of spironolactone was observed in the absence of RAS inhibitors. Atherosclerosis is accepted as a common mechanism underlying all CVDs and atherosclerotic CVD is a significant cause of morbidity and mortality in patients with ESRD (1-3). Prospective studies have shown an association between increased CIMT and the incidence of CVDs (16-18). In fact, CIMT is a well described surrogated marker for cardiovascular risk (10-14). A thickened CIMT correlates with the presence of myocardial infarction and stroke by cross-sectional analysis (13). In some countries, recommendations already suggest that carefully performed IMT measurement can add incremental information to traditional risk factor assessment (European Society of Cardiology Guidelines). The main advantage of using CIMT as an end point in a trial concerning morbidity and mortality is the considerable reduction in sample size and ...
Background:B-mode ultrasound measurements of the echolucency of the carotid intima-media may hold information on cardiovascular risk. The information obtained from this measurement may depend on which gain settings are used. We studied the effect of gain settings on echolucency measurements and its consequences on risk factor relations and treatment effects.Methods:We used two approaches. In the first, we examined the relationship between calibration, gain and common grey-scale median (GSM) from repeated ultrasound images obtained from four healthy individuals at gain settings ranging from -20 to 20dB. In the second, we evaluated the effect of gain settings on the relation of risk factors and statin treatment with common GSM, using images from 325 participants of the Measuring Effects on Intima-Media Thickness: an Evaluation of Rosuvastatin (METEOR) study with documented gain settings. Echolucency of the carotid intima-media was measured from ultrasound images using PaintShop Pro and Artery ...
TY - JOUR. T1 - Individual measurement and significance of carotid intima, media, and intima-media thickness by B-mode ultrasonographic image processing. AU - Bae, Jang Ho. AU - Kim, Wuon Shik. AU - Rihal, Charanjit S.. AU - Lerman, Amir. PY - 2006/10/1. Y1 - 2006/10/1. N2 - OBJECTIVE - We assessed the clinical significance of intima (IT), media (MT), and intima-media (IMT) thickness of the common carotid artery using B-mode ultrasonographic image processing. METHODS AND RESULTS - One hundred seventy consecutive patients underwent common carotid artery scanning using high-resolution ultrasonography. A total of 150 patients could be analyzed off-line using ultrasonographic image processing, devised for individual measurement of IT, MT, and IMT. By univariate analysis, IT (range, 0.27 to 0.41 mm) was associated with age, whereas MT (range, 0.27 to 0.74 mm) and IMT (range, 0.49 to 1.12 mm) were associated with age, fibrinogen, and creatinine. Among atherosclerosis risk factors, hypertension was ...
TY - JOUR. T1 - Characterization of intravascular cellular activation in relationship to subclinical atherosclerosis in postmenopausal women. AU - Jayachandran, Muthuvel. AU - Garovic, Vesna D.. AU - Mielke, Michelle M.. AU - Bailey, Kent R.. AU - Lahr, Brian D.. AU - Miller, Virginia M.. PY - 2017/9. Y1 - 2017/9. N2 - Objective Mechanisms and interactions among intravascular cells contributing to development of subclinical atherosclerosis are poorly understood. In women, both menopausal status and pregnancy history influence progression of atherosclerosis. This study examined activation and interactions among blood elements with subclinical atherosclerosis in menopausal women with known pregnancy histories. Methods Carotid intima-media thickness (CIMT), as a marker of subclinical atherosclerosis, was measured using B-mode ultrasound in age- and parity-matched women [40 with and 40 without a history of preeclampsia] 35 years after the index pregnancy. Interactions among intravascular cells (38 ...
We have shown that even after adjusting for multiple confounding factors, a tertiary care cohort of psoriasis patients have a 2.67-fold higher odds of having atherosclerosis compared to controls. The most striking finding was that after age stratification, almost half (49 %) of patients with psoriasis aged 30-39 years had evidence of subclinical atherosclerosis as compared to 15 % of controls. These findings are suggestive that psoriasis may contribute to the inflammatory cascade of atherosclerosis and that the younger a patient develops psoriasis, the higher the CVD risk. These findings are consistent with recent observations from preclinical models systems, wherein chronic skin-contained inflammation, but not acute, promoted the acceleration of arterial thrombosis [19] and [20]. In addition, other investigators have also reported observational studies demonstrating relatively higher measures of association with CV events in younger individuals [25, 42-44]. Psoriasis sufferers with ...
SwePub titelinformation: Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration
After controlling for age and sex, we report not only that CHD risk factors but also that CCA and ICA IMTs are elevated in individuals before the onset of clinical diabetes. Moreover, increased CCA IMT predicted diabetes. Hence, in our study population, we have established that early atherogenesis, not merely elevated cardiovascular risk factors, is present before the development of clinical diabetes, and thus, enhanced atherogenesis is not solely dependent on the clinical manifestation of diabetes.. Jarrett,15 Jarrett and Shiply,16 and later Stern17,18 hypothesized not only that diabetes and cardiovascular disease are related as cause and effect but also that both conditions originate from a common soil. This hypothesis suggests an atherogenic state before the onset of clinical diabetes, which is consistent with the regularly reported finding that CHD risk factors are elevated in prediabetic individuals1-5 and the recently reported finding in the Nurses Health Study (NHS) of elevated ...
Objectives: This study aims to evaluate the relationship between serum homocysteine levels and atherosclerotic plaques in carotid arteries in female patients with rheumatoid arthritis (RA). ...
This proposed prospective, randomized, controlled study aims to investigate the effects of high flux dialyser use and ultra pure dialysate utilization on cardiovascular disease by evaluating cardiovascular morbidity and mortality, progression of carotid artery intima-media thickness and coronary artery calcifications, inflammatory state, lipid levels, nutritional status, and erythropoietin requirement in hemodialysis patient population. It is hypothesized that both interventions in this project may diminish cardiovascular disease in hemodialysis patients.. Their beneficial effects may be directly represented by significantly reduced cardiovascular morbidity and mortality. The proposed additional investigations, such as a possible decrease in the progression of coronary artery calcification and carotid artery intima-media thickness, will help us to understand the mechanisms of the expected reduction or serve as surrogate markers of atherosclerosis, in case the benefit of the interventions cannot ...
Evidences indicate that skeleton works not only as a structural scaffold but also as an endocrine organ. Many bioactive factors secreted from bone, such as osteocalcin and osteoprotegerin, have a regulatory role in energy metabolism [21, 22]. Recent studies have suggested a potentially important role for osteocalcin in regulating the function of vascular endothelial cells, and the cardiovascular system [23, 24]. This suggests osteocalcin could be involved in the development of CAD. Several studies have investigated the association between osteocalcin and atherosclerosis, but results have not been consistent. Some studies suggest osteocalcin may actually be protective against early atherosclerosis. For example, a study from Korea demonstrated an independent effect of osteocalcin on vascular endothelial cells, suggesting that osteocalcin could have beneficial effects on atherosclerosis [25]. Our previous study in high fat diet animals indicate that osteocalcin has an endothelial-protective effect ...
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Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular risk. We hypothesized that the number of cardiovascular risk factors determines the progression of vascular aging. One hundred forty-two subjects (mean age 51.9 years, 94 men) without established cardiovascular disease were investigated in 2 examinations over a 2-year period. Subjects were classified at baseline according to their number of risk factors (from 0 to 2 and more). Subjects had determinations of carotid-femoral pulse wave velocity, aortic augmentation index, brachial flow-mediated dilatation, and common carotid intima-media thickness and their annual absolute changes were calculated. Subjects with more risk factors had a gradual higher annual progression of pulse wave velocity (0.092 m/s/y for 0, 0.152 m/s/y for 1, and 0.352 m/s/y for 2 and more; P=0.007). Patients with both hypertension and dyslipidemia have 4× higher annual progression rate compared with ...
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality and disability in most countries (1). Approximately 30% of first acute events are fatal, and survivors often experience sequelae and a shortened life expectancy (2,3). Primary prevention is thus the best approach to fighting this pandemic disease. Current algorithms for risk detection, which combine behavioral, clinical, and biochemical markers, are of limited accuracy, and better risk stratification methods are definitely needed (4,5).. Used in combination with traditional risk factors, data on subclinical atherosclerosis can provide additional information about the risk of myocardial infarction, stroke, and cardiovascular disease (CVD) mortality (6-8). Carotid wall intima-media thickness estimated from ultrasonographic images has been proposed as a surrogate measure of subclinical atherosclerosis (9). Whereas some prospective studies have shown that intima-media thickness adds predictive capacity to traditional ...
Afaq F, Saleen M, et al. Anthocyanin- and Hydrolyzable Tannin-Rich Pomegranate Fruit Extract Modulates MAPK and NF-kappaB Pathways and Inhibits Skin Tumorigenesis in CD-1 Mice. Int. J. Cancer 2005; 113(3): 423-433.. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004; 23(3): 423-33.. Rasheed Z, Akhtar N, et al. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. Journal of Inflammation 2009; 6(1). ...
Afaq F, Saleen M, et al. Anthocyanin- and Hydrolyzable Tannin-Rich Pomegranate Fruit Extract Modulates MAPK and NF-kappaB Pathways and Inhibits Skin Tumorigenesis in CD-1 Mice. Int. J. Cancer 2005; 113(3): 423-433.. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004; 23(3): 423-33.. Rasheed Z, Akhtar N, et al. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. Journal of Inflammation 2009; 6(1). ...
Ultrasound study to assess Carotid Intima Media Thickness in an office setting 525 patients to be enrolled at seven medical centers DALLAS - November 13, 2005 - SonoSite, Inc. (NASDAQ: SONO), the world leader in hand-carried ultrasound, announced today at the 2005 American Heart Association (AHA) Scientific Sessions that it is initiating a multi-center study to determine whether the addition of an ultrasound examination evaluating carotid artery wall thickness (CIMT), performed in the office setting, will provide a more effective tool for risk assessment and prevention of cardiovascular disease than current clinical methods alone. Over 20 years of clinical research has shown that the thickness (T) of the two innermost layers of the carotid artery wall, the intima (I) and media (M), begins to increase before plaque is evident within the vessel. This increased wall thickness is associated with an increased risk of cardiovascular disease, the leading cause of mortality and disability in the United States
We read with interest the article by Mita et al. (1) in Diabetes Care reporting a beneficial effect of sitagliptin on the progression of carotid intima-media thickening in Japanese patients with type 2 diabetes. This article parallels another article highlighting the prevention of the progression of carotid atherosclerosis by alogliptin in patients with type 2 diabetes (2). The two articles appeared in the same journal (Diabetes Care) in 2016, were conducted by the same group, had the same first author, and had the same (almost identical) baseline values of carotid intima-media thickness (IMT) among the patients with diabetes. The two studies also had important differences concerning duration of diabetes (17.2 years sitagliptin vs. 9 years alogliptin), baseline HbA1c (8.1% vs. 7.3%), and insulin use (all sitagliptin patients vs. no alogliptin patients). So, at least in Japanese people, three of the main clinical aspects that characterize type 2 diabetes-duration of disease, baseline HbA1c, and ...
Background- Genome-wide association studies have recently identified a locus on chromosome 9p21 that influences risk of coronary artery disease (CAD). The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD). Methods and Results- We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD. Both mean and maximum CIMT were significantly higher (P,0.001) in the older subjects of the Health 2000 Survey compared with the Young Finns Study. However, there was no association of the rs1333049 genotype with either mean or maximum CIMT at either age (P=0.959 and 0.977 for the 2 phenotypes in the Young Finns Study and P=0.714 and 0.725 in the ...
Childhood obesity is associated with an increased carotid intima-media thickness (IMT) and stiffness. Increased carotid wall thickening and rigidity are considered markers of subclinical atheroscleros
Aims: Vitamin E (Vit-E) may preferentially improve cardiovascular risk in haptoglobin 2-2 (Hp2-2) genotype diabetes individuals. We studied the impact of Vit-E supplementation on vascular function in diabetes individuals stratified by haptoglobin genotype in Singapore.. Methods: In this 24-week, double blind, placebo-controlled RCT, we recruited 187 subjects (101 Hp2-2, 86 non-Hp2-2).. Intervention: alpha-tocopherol-400 IU.. Primary outcome: Change in EndoPAT-derived reactive-hyperaemia index (RHI) and augmentation index (AIx); Secondary Outcomes: Pulse-Wave velocity (Sphygmocor-PWV), carotid intima media thickness (CIMT), inflammation (hsCRP), derivatives of reactive-oxygen metabolites (dROMs), biological antioxidant-potential (BAPs), HbA1c, LDL-C, HDL-C and oxidised LDL-C (ox-LDL).. Results: Overall, with Vit-E supplementation no significant change in RHI, PWV, CIMT, hsCRP, dROMS, BAPs, HDL-C and HbA1c was observed (p , 0.05); an increase in LDL-C with concomitant decrease in ox-LDL, and ...
A Syngle1, I Verma2, N Garg2, P Krishan2. 1Cardio Rheuma, Healing Touch City Clinic and Fortis Hospital, Chandigarh, India,. 2Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Objectives: Ankylosing spondylitis (AS) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that depleted endothelial progenitor cells (EPCs), mediators of inflammation and carotid intima media thickness (cIMT) are associated with atherosclerosis in other populations and would be increased and associated with the severity of coronary atherosclerosis in patients with AS. Methods: We compared 30 patients of AS with 22 healthy controls. CD34+, CD133+, were used to quantify EPCs using flow cytometry. Flow-mediated dilatation (FMD) was assessed by using AngioDefenderTM (Everist Health, Ann Arbor, MI, United States). CIMT was measured using ultrasonography. Pro-inflammatory cytokines and inflammatory disease activity measures, Bath Ankylosing Spondylitis ...
A Syngle1, I Verma2, N Garg2, P Krishan2. 1Cardio Rheuma, Healing Touch City Clinic and Fortis Hospital, Chandigarh, India,. 2Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Objectives: Ankylosing spondylitis (AS) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that depleted endothelial progenitor cells (EPCs), mediators of inflammation and carotid intima media thickness (cIMT) are associated with atherosclerosis in other populations and would be increased and associated with the severity of coronary atherosclerosis in patients with AS. Methods: We compared 30 patients of AS with 22 healthy controls. CD34+, CD133+, were used to quantify EPCs using flow cytometry. Flow-mediated dilatation (FMD) was assessed by using AngioDefenderTM (Everist Health, Ann Arbor, MI, United States). CIMT was measured using ultrasonography. Pro-inflammatory cytokines and inflammatory disease activity measures, Bath Ankylosing Spondylitis ...
A Syngle1, I Verma2, N Garg2, P Krishan2. 1Cardio Rheuma, Healing Touch City Clinic and Fortis Hospital, Chandigarh, India,. 2Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Objectives: Ankylosing spondylitis (AS) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that depleted endothelial progenitor cells (EPCs), mediators of inflammation and carotid intima media thickness (cIMT) are associated with atherosclerosis in other populations and would be increased and associated with the severity of coronary atherosclerosis in patients with AS. Methods: We compared 30 patients of AS with 22 healthy controls. CD34+, CD133+, were used to quantify EPCs using flow cytometry. Flow-mediated dilatation (FMD) was assessed by using AngioDefenderTM (Everist Health, Ann Arbor, MI, United States). CIMT was measured using ultrasonography. Pro-inflammatory cytokines and inflammatory disease activity measures, Bath Ankylosing Spondylitis ...
Chronic inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis and infections, such as periodontal disease and HIV, are associated with an increased risk of cardiovascular disease. Patients with these disorders also have an increase in coronary artery calcium measured by CT and carotid intima media thickness measured by ultrasound. Inflammation and infections induce a variety of alterations in lipid metabolism that may initially dampen inflammation or fight infection, but if chronic could contribute to the increased risk of atherosclerosis. The most common changes are decreases in serum HDL and increases in triglycerides. The increase in serum triglycerides is due to both an increase in hepatic VLDL production and secretion and a decrease in the clearance of triglyceride rich lipoproteins. The mechanisms by which inflammation and infection decrease HDL levels are uncertain. There is also a consistent increase in lipoprotein (a) levels due to increased
The primary prevention of cardiovascular disease involves classifying individuals according to their global cardiovascular risk. However, those at intermediate risk represent a particular challenge; while some may require aggressive treatment, others may be best managed by lifestyle measures alone. Biomarkers that have shown promise in improving risk discrimination include carotid intima-media thickness (CIMT), coronary artery calcium (CAC) scoring, brachial flow-mediated dilation (FMD), ankle-brachial index (ABI), high-sensitivity C-reactive protein (CRP) and, in addition, having a family history of coronary heart disease (CHD). Determining whether - and by how much - risk prediction can be improved by various markers could help to determine the most efficient strategy for the use of primary prevention drugs.. 1330 intermediate risk participants (Framingham risk score of ,5% and ,20% for a coronary event within the next ten years) in the Multi-Ethnic Study of Atherosclerosis (MESA) were ...
Background: Studies have shown that carotid intima-media thickness (CIMT) and ankle-brachial pressure index (ABI) can be used as surrogate markers of coronary artery disease (CAD). However, whether studying the ratio of ABI and CIMT has any added value in predicting CAD when compared to either of them alone, has not been studied. Aims: The aim of the study is to compare CIMT and ABI as surrogate markers for the presence and extent of CAD and to investigate whether studying the ratio of ABI and CIMT has any incremental value in predicting CAD than either of them. Methods: We prospectively enrolled 235 stable, non-ACS patients who underwent CIMT and ABI measurements followed by diagnostic coronary angiography. Results: The mean age of the study population was 56.32 ± 10.14 years. CIMT was significantly higher in the CAD group compared to non-CAD group (0.91 ± 0.22 vs. 0.66 ± 0.15, P ≤ 0.0001). ABI was significantly lower in the CAD group compared to non-CAD group (1.07 ± 0.19 vs. 1.18 ± ...
Conclusions Cumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima-media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may...
Garovic VD, Milic NM, Weissgerber TL, Mielke MM, Bailey KR, Lahr B, Jayachandran M, White WM, Hodis HN, Miller VM. Carotid Artery Intima-Media Thickness and Subclinical Atherosclerosis in Women With Remote Histories of Preeclampsia: Results From a Rochester Epidemiology Project-Based Study and Meta-analysis. Mayo Clin Proc. 2017 Sep; 92 (9):1328-1340 Epub 2017 Aug 25 ...
TY - JOUR. T1 - The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. AU - Wijnands, J.M.A.. AU - Boonen, A.. AU - Dagnelie, P.C.. AU - van Greevenbroek, M.M.J.. AU - van der Kallen, C.J.H.. AU - Ferreira, I.. AU - Schalkwijk, C.G.. AU - Feskens, E.J.M.. AU - Stehouwer, C.D.A.. AU - van der Linden, S.. AU - Arts, I.C.W.. N1 - WOS:000344644800024. PY - 2014. Y1 - 2014. N2 - Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased ...
Significant evidence has accumulated that psychosocial stress contributes to the etiology and pathogenesis of coronary artery disease. In addition to direct influences through the nervous, endocrine, and immune systems, stress reduces the adoption and maintenance of a healthy lifestyle and adherence to medical care (1). Epidemiological evidence is compelling; several large and international studies have shown that individuals reporting high levels of psychosocial stress have significantly elevated risk of cardiovascular diseases. Most notably, the INTERHEART study demonstrated that among more than 30,000 individuals, those who reported elevated stress had odds ratios for myocardial infarction of 2.5 (2). High work demands and daily stress have also been associated with coronary heart disease (CHD) morbidity and mortality, with carotid artery intima-media thickness progression, and with recurrent events. The most recent addition to this literature was the finding in the prospective Womens Health ...
Therapy-resistant hypertension was present in 9.1% of hypertensive patients with clinically manifest vascular disease and 49.5% had uncontrolled but non-resistant hypertension. Clinical characteristics related to aTRH were higher age, female sex, BMI and waist circumference, diabetes mellitus and duration and multiple locations of vascular disease, lower eGFR and albuminuria. Patients with aTRH had greater carotid intima-media thickness and lower ABI representing greater burden of subclinical vascular damage.. The prevalence of aTRH has been reported to be 9%-13% in the general hypertensive population.20-22 In patients with chronic kidney disease (CKD), known for their high cardiovascular risk, a much higher prevalence of 25%-35% has been found, often using a more stringent BP definition of ,130/80 mm Hg.23-25 Although several reports have shown a higher prevalence of vascular disease in those with aTRH in hypertensive populations,21 22 26-28 the exact aTRH prevalence in patients with clinical ...
The results of this study suggest that HI statin therapy provides a mortality benefit over LMI statin therapy in patients with PAD. This effect was accompanied by a significant reduction in MACE and is consistent with the results of several large randomized controlled trials demonstrating reduced mortality and secondary ischemic events in patients with atherosclerosis of the coronary and cerebral vasculature treated with HI statin therapy.13, 14, 15, 18. The benefit of lowering LDL in preventing MACE has been well described, particularly among patients with coronary atherosclerosis. HI statins exert potent LDL‐lowering effects and may mediate additional benefits through pleiotropic mechanisms leading to atherosclerotic regression and plaque stabilization.19, 20 Indeed, mechanistic studies have demonstrated that HI statin therapy (atorvastatin 80 mg daily) is associated with greater regression of carotid intima-media thickness and coronary atherosclerosis compared with moderate‐intensity ...
The researchers selected 24 men with severe OSA and no other comorbidities and randomly assigned them to receive either CPAP therapy or no treatment. After establishing the baseline data for each subject, they then tracked several indicators of pre-clinical atherosclerosis, including carotid intima-media thickness (a measure of arterial plaque), pulse-wave velocity (a measure of arterial stiffness), carotid diameter, C-reactive protein (a marker of inflammation), and catecholamine level (a marker of physical stress) over the course of four months ...
Exposure to passive smoking in childhood causes irreversible damage to the structure of childrens arteries, according to a study published online in the European Heart Journal [1].. The thickening of the arteries walls associated with being exposed to parents smoke, means that these children will be at greater risk of heart attacks and strokes in later life. The researchers from Tasmania, Australia and Finland say that exposure to both parents smoking in childhood adds an extra 3.3 years to the age of blood vessels when the children reach adulthood.. The study is the first to follow children through to adulthood in order to examine the association between exposure to parental smoking and increased carotid intima-media thickness (IMT) - a measurement of the thickness of the innermost two layers of the arterial wall - in adulthood. It adds further strength to the arguments for banning smoking in areas where children may be present, such as cars.. The study was made up of 2401 participants in ...
American Society of Echocardiography Carotid Intima-Media Thickness Task Force (2008). "Use of Carotid Ultrasound to Identify ... A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the ...
October 2010). Federici M (ed.). "The relationships of markers of cholesterol homeostasis with carotid intima-media thickness ... Differences in cholesterol homeostasis affect the development of early atherosclerosis (carotid intima-media thickness). These ... ISBN 978-0-7167-2009-6. "The Nobel Prize in Physiology or Medicine, 1964". =Nobel Prize, Nobel Media. Espenshade PJ, Hughes AL ...
Common carotid intima- media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012 Aug 22;308(8 ...
Cheung YF, Wong SJ, Ho MH (January 2007). "Relationship between carotid intima-media thickness and arterial stiffness in ... Other vascular complications can occur such as increased wall thickness and decreased distensibility of carotid arteries, aorta ... Kawasaki disease may be further classified as a medium-sized vessel vasculitis, affecting medium- and small-sized blood vessels ... Brandt HR, Arnone M, Valente NY, Sotto MN, Criado PR (2009). "[Medium and large vessel vasculitis]". Anais Brasileiros de ...
Riccioni G (2009). "The effect of antihypertensive drugs on carotid intima media thickness: an up-to-date review". Current ... Persistently elevated blood pressure leads to intimal thickening, hyperplasia of the media wall, and hyaline degeneration in ...
Riccioni G (2009). "The effect of antihypertensive drugs on carotid intima media thickness: an up-to-date review". Current ...
"Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives". Am J ...
"Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray". ...
"Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study". Stroke: A ...
July 2007). "Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double- ... "Phase III Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin ... following media and physician criticism, Pfizer had subsequently planned for torcetrapib to be sold independently of Lipitor. A ...
O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK (January 1999). "Carotid-artery intima and media thickness ... Testing for plaque includes a carotid intima-media thickness test, (CIMT), which measures blood flow through the arteries and ... Doneen AL, Bale BF (March 2013). "Carotid intima-media thickness testing as an asymptomatic cardiovascular disease identifier ... "Effect of comprehensive cardiovascular disease risk management on longitudinal changes in carotid artery intima-media thickness ...
Furthermore, rs11556924 has also been associated with altered carotid intima-media thickness in patients with rheumatoid ... "The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid ...
2010). "Silent cerebral infarction is associated with incident stroke and TIA independent of carotid intima-media thickness". ...
"Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities ( ... Play media In the early stages, periodontitis has very few symptoms, and in many individuals the disease has progressed ...
Provost, E; Madhloum, N; Int Panis, L; De Boever, P; Nawrot, TS (May 2015). "Carotid intima-media thickness, a marker of ... London, UK: Guardian Media Group. 15 April 2008. Archived from the original on 20 April 2008. Retrieved 15 April 2008. "Car ... which can attach to particulates Play media Persistent organic pollutants (POPs) are organic compounds that are resistant to ...
Provost EB, Madhloum N, Int Panis L, De Boever P, Nawrot TS (2015). "Carotid intima-media thickness, a marker of subclinical ... carotid IMT (intimal media thickness) measurement by ultrasound, and intravascular ultrasound (IVUS). Examples of physiologic ... "Fine particulate air pollution and the progression of carotid intima-medial thickness: a prospective cohort study from the ... Carotid arteries supply blood to the brain and neck. Marked narrowing of the carotid arteries can present with symptoms such as ...
"Chronic carbon monoxide exposure is associated with the increases in carotid intima-media thickness and C-reactive protein ...
Relation of parity with common carotid intima-media thickness among women of the Study of Health in Pomerania (SHIP). Stroke ... Thyroid function and carotid wall thickness. J Clin Endocrinol Metab 2004;89:2145-2149 Völzke H, Werner A, Wallaschofski H, ... Association between high serum ferritin levels and carotid atherosclerosis in the Study of Health in Pomerania (SHIP). Stroke ...
... and the Carotid Intima-Media Thickness in Patients with Dyslipidemia". Journal of Atherosclerosis and Thrombosis. 22 (11): 1158 ...
"Lysophosphatidylcholine and Carotid Intima-Media Thickness in Young Smokers: A Role for Oxidized LDL-Induced Expression of PBMC ... Intima-media thickness, which is positively correlated with reduced blood flow, was studied in young smokers. Evidence pointed ... due to tobacco smoke's impact on oxidation of retained LDL particles in the intima of a carotid artery. which may have a ...
... as judged by carotid intima-media thickness measurements. Variant alleles involved deletions (one or two) or additions (one, ...
"Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease ...
Subclinical atherosclerosis, which was assessed by carotid intima-media thickness, was also reduced significantly over a ...
... established and candidate risk factors in well characterized populations using the intima-media thickness of the common carotid ... Association of postprandial triglyceride and retinyl palmitate responses with asymptomatic carotid artery atherosclerosis in ...
Spence pioneered the use of carotid plaque measurement (as opposed to intima-media thickness) for research and for management ... Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy Stroke. 2002;33:2916-2922 Stroke 1986; 17( ... Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy Stroke. 2002;33:2916-2922 Stroke 1999;30: ... The effect of drug therapies on carotid plaque volume can now be evaluated in a very cost-effective way. Development of ...
... a sub-field of computer-aided translation Intima-media thickness, a measurement of the thickness of artery walls. Also ... Carotid intimal-medial thickness. This disambiguation page lists articles associated with the title IMT. If an internal link ...
Promising results are found using carotid intima-media thickness scanning (CIMT can be measured by B-mode ultrasonography), B- ... Carotid Intima-media thickness Scan (CIMT can be measured by B-mode ultrasonography) measurement has been recommended by the ... which have supported a direct correlation of Carotid Intima-media thickness (CIMT) with myocardial infarction and stroke risk ... Arterial ultrasound, especially of the carotid arteries, with measurement of the thickness of the artery wall, offers a way to ...
"Carotid intima-media thickness, a marker of subclinical atherosclerosis, and particulate air pollution exposure: the meta- ... London, UK: Guardian Media Group. 2008-04-15. Archived from the original on 20 April 2008. Retrieved 2008-04-15.. ...
... intima-media thickness, leukoaraiosis, cerebral microbleeds (CMB), atau multiple lacunae.[9] CMB adalah deposit hemosiderin ... Beberapa ahli lain mempertimbangan klasifikasi berdasarkan fenotipe seperti keberadaan internal carotid artery plaque, ... extracranial carotid ultrasonography, dan jika memungkinkan, cerebral angiography. ...
... as judged by carotid intima-media thickness measurements. Variant alleles involved deletions (one or two) or additions (one, ...
The vascular wall consists of several layers known as the tunica externa, tunica media, and tunica intima. The thickness of the ... Left common carotid artery. Left subclavian artery. Descending aorta, thoracic part: Left bronchial arteries. esophageal ... For example, the left vertebral artery may arise from the aorta, instead of the left common carotid artery.[9]:188 ... The aortic arch has three major branches: from proximal to distal, they are the brachiocephalic trunk, the left common carotid ...
The inner layer, Tunica intima, is the thinnest layer. It is a single layer of flat cells (simple squamous epithelium) glued by ... The tunica media may (especially in arteries) be rich in vascular smooth muscle, which controls the caliber of the vessel. ... Blood viscosity is the thickness of the blood and its resistance to flow as a result of the different components of the blood. ... common carotid. *External carotid. *Internal carotid. *Carotid body. *Carotid sinus. *Carotid bifurcation ...
"The effect of antihypertensive drugs on carotid intima media thickness: an up-to-date review". Current Medicinal Chemistry. 16 ...
"Silent cerebral infarction is associated with incident stroke and TIA independent of carotid intima-media thickness". Intern. ... Ederle J, Brown MM (2006). "The evidence for medicine versus surgery for carotid stenosis". European Journal of Radiology. 60 ( ...
"Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes". ...
Smooth muscle cells migrate from the media to the intima, proliferate, and develop an extracellular matrix made up of collagen ... such as the carotid or femoral arteries. While stability vs. vulnerability cannot be readily distinguished in this way, ... is to use ultrasound to non-invasively measure wall thickness (usually abbreviated IMT) in portions of larger arteries closest ... are absorbed into the intima, past the endothelium lining, some of the LDL-lipoprotein particles become oxidized and this ...
A true aneurysm is one that involves all three layers of the wall of an artery (intima, media and adventitia). True aneurysms ... Similarly, sometimes it is difficult to model the varying wall thickness in small vessels, so researchers treat wall thickness ... The next most common sites of cerebral aneurysm occurrence are in the internal carotid artery. Abdominal aortic aneurysms are ... The neck of the aneurysm is the most at risk due to the combination of a small wall thickness and high wall shear stress. When ...
A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque buildup in the arteries supplying blood ... What is a Carotid Intima-Media Thickness Test?. A carotid intima-media thickness test (CIMT), also known as a carotid artery ... Carotid Intima-Media Thickness Test. A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque ... CIMT uses ultrasound imaging to measure the thickness of the two inner layers of the carotid artery-called the intima and media ...
The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128: 262-269. ... Periodontal Microbiota and Carotid Intima-Media Thickness. Moïse Desvarieux, Ryan T. Demmer, Tatjana Rundek, Bernadette Boden- ... Periodontal Microbiota and Carotid Intima-Media Thickness. Moïse Desvarieux, Ryan T. Demmer, Tatjana Rundek, Bernadette Boden- ... Periodontal Microbiota and Carotid Intima-Media Thickness. The Oral Infections and Vascular Disease Epidemiology Study (INVEST) ...
Intima-media thickness was measured in the right and left common carotid artery, bulb, and internal carotid artery. Mean IMT (m ... Factors underlying the increase in carotid intima-media thickness in borderline hypertensives.. Pauletto P1, Palatini P, Da Ros ... To define the role played by various risk and behavioral factors in the increase of carotid intima-media thickness (IMT) ... an increase in IMT takes place not only in the common carotid artery but also in the bulb and the internal carotid segment. ...
Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy. The Chennai Urban Rural ... Ravikumar R, Deepa R, Shanthirani C, Mohan V: Comparison of carotid intima-media thickness, arterial stiffness, and brachial ... Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy ... Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy ...
Our study examined the association of long-term exposure to traffic with carotid intima-media thickness (cIMT) in 287 healthy ... Residential Exposure to Urban Traffic Is Associated with Increased Carotid Intima-Media Thickness in Children. Rodrigo X. ... and reproduction in any medium, provided the original work is properly cited. ...
Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were evaluated before and after treatment ... Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes.. Mita T1, ... this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with ...
"Normative values and correlates of carotid artery intima-media thickness and carotid atherosclerosis in Andean-Hispanics: the ... V. T. Kotsis, S. V. Stabouli, C. M. Papamichael, and N. A. Zakopoulos, "Impact of obesity in intima media thickness of carotid ... A. Z. Fan and J. H. Dwyer, "Sex differences in the relation of HDL cholesterol to progression of carotid intima-media thickness ... J. J. Cao, C. Thach, T. A. Manolio et al., "C-reactive protein, carotid intima-media thickness, and incidence of ischemic ...
The RhGH replacement therapy in GHD children can improve both the blood lipid profile and carotid intima-media thickness, with ... therapy on blood lipid and carotid intima-media thickness (cIMT) in Chinese GHD children. Ninety children, including sixty ... Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency. J Clin ... A study of carotid intima-media thickness in GH-deficient Japanese adults during onset among adults and children. Eur J ...
Background: Carotid intima-media thickness (IMT), measured with B-mode ultrasound, is a marker for atherosclerosis and widely ... COMPARATIVE STUDY OF CAROTID INTIMA MEDIA THICKNESS IN ISCHEMIC STROKE SUBTYPES. Mutu, Cosmin; Minea, Nicoleta; Pereanu, Marcel ... BACKGROUND: Although carotid intima-media thickness (IMT) is the most commonly used ultrasonic measurement of atherosclerosis, ... Flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of the carotid artery are two parameters ...
Association of blood pressure levels with carotid intima-media thickness and plaques were found in PRIME PubMed. Download Prime ... Common carotid artery intima-media thickness, carotid plaques, and walking speed.. *Which factors are related to the presence ... Relevance of common carotid intima-media thickness and carotid plaque as risk factors for ischemic stroke in patients with type ... Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness. ...
Furthermore, the usefulness of maximum carotid intima-media thickness (maximum-IMT) as a surrogate marker of coronary artery ... Risk factors and utility of maximum carotid intima-media thickness as a surrogate marker for coronary artery stenosis Keiji ... Risk factors and utility of maximum carotid intima-media thickness as a surrogate marker for coronary artery stenosis. ... Furthermore, the usefulness of maximum carotid intima-media thickness (maximum-IMT) as a surrogate marker of coronary artery ...
Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes.. ... Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. ... Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. ... Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. ...
PubMed journal article Does B-mode common carotid artery intima-media thickness differ from M-model? were found in PRIME PubMed ... Individual measurement and significance of carotid intima, media, and intima-media thickness by B-mode ultrasonographic image ... The present study compares intima-media thickness of the common carotid artery measured with the two techniques. Intima-media ... The present study compares intima-media thickness of the common carotid artery measured with the two techniques. Intima-media ...
Carotid intima-media thickness in plaque-free site, carotid plaques and coronary heart disease risk prediction in older adults ... Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: A meta- ... Is carotid intima media thickness useful for individual prediction of cardiovascular risk? Ten-year results from the Carotid ... Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th ...
... long duration or high cumulative exposure levels is associated with subclinical atherosclerosis as manifested through carotid ... Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh Int J Epidemiol. 2014 Aug;43(4): ... Keywords: Areca nut; Bangladesh; betel nut; cardiovascular disease; carotid intima-media thickness. ... and carotid IMT was measured on average 6.65 years after baseline. ...
In children, increased intima-media thickness is associated with obesity and the risk of... ... Background Common carotid artery intima-media thickness is a marker of subclinical atherosclerosis. ... Common carotid artery intima-media thickness is a marker of subclinical atherosclerosis. In children, increased intima-media ... intima-media thickness differed significantly depending on technique. Mean intima-media thicknesses are shown in Fig. 4.. Open ...
This cross-sectional study aims at measuring the effect of atherosclerosis assessed through carotid intima-media thickness ( ... Thicker carotid intima-media thickness and increased plasma VEGF levels suffered by post-acute thrombotic stroke patients Yuyun ... Thicker carotid intima-media thickness and increased plasma VEGF levels suffered by post-acute thrombotic stroke patients. ... This cross-sectional study aims at measuring the effect of atherosclerosis assessed through carotid intima-media thickness ( ...
Carotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts. L.M. Cupini, P. Pasqualetti, M. Diomedi, F. ... The role of carotid artery intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128: 262-269. ... Carotid-artery intima media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999 ... Carotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts. L.M. Cupini, P. Pasqualetti, M. Diomedi, F. ...
Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of ... The IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European ... Sex-specific effects of adiponectin on carotid intima-media thickness and incident cardiovascular disease. J Am Heart Assoc ... Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European ...
Keywords: silent cerebral infarction, carotid intima-media thickness, incident stroke, cohort study, magnetic resonance imaging ... Background Both silent cerebral infarction (SCI) and carotid intima-media thickness (IMT) are associated with future stroke. We ... Both SCI and carotid IMT at baseline were associated with incident stroke/TIA events after adjustment for age, sex, and ... The predictive value of SCI remained significant even after adjustment for carotid IMT (HR 8.56; 1.72-42.55).. Conclusion SCI, ...
... J Clin Endocrinol Metab. 2008 ... who provided complete home blood glucose profiles and centralized carotid intima-media thickness (CIMT) assessment. The study ... CIMT was assessed by carotid sonography. Results: The level of glycosylated hemoglobin and CIMT progressively increased across ... size and timing of post-meal glucose peaks in the everyday life of type 2 diabetic patients and the relationship with carotid ...
Carotid intima-media thickness (IMT) relates to the 2 innermost layers of the arterial wall: the intima and the media. The ... Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. Ann Epidemiol. ... Relationship between intima-media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation. Stroke ... Carotid intima-media thickness at different sites: Relation to incident myocardial infarction. Eur Heart J. 2002;23:934-940. ...
Common carotid artery intima-media thickness and brain infarction. Circulation. 2000; 102: 313-318. ... Cytokine Polymorphisms Associated With Carotid Intima-Media Thickness in Stroke Patients. David Brenner, Julien Labreuche, ... Measuring carotid intima-media thickness (IMT) is a powerful technique for studying atherosclerosis. IMT is determined by ... OLeary D, Polak J, Kronmal P. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke ...
Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults. Praveen ... Background: African Americans tend to have greater carotid intima-media thickness (IMT), and are 60% more likely to have a ... Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults ... Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults ...
carotid intima media thickness [ Time Frame: once (1 day) ]. By carotid doppler ... Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients. The safety and scientific ... Adiponectin, Interleukin-6 (IL-6) and High Sensitive C-reactive Protein (hsC-RP) in Relation to Carotid Intima-media Thickness ... Diagnostic Test: Interleukin-6 Diagnostic Test: HsC-RP Diagnostic Test: Adiponectin level Diagnostic Test: Carotid intima media ...
Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients ... Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients ... intima-media-thickness. dyslipidemia. progression of atherosclerosis. peripheral artery disease. major cardiovascular events. ... beneficial effects on lipid status may have contributed to a stabilization or regression of carotid intima-media-thickness (IMT ...
Change of carotid intima media thickness 1 year after pravastatin or rosuvastatin treatment [ Time Frame: 1 year after drug- ... Carotid Intimamedia thickness (CIMT) is a surrogate marker of atherosclerosis to predict long term cardiovascular outcomes in ... Comparing the Effect of Pravastatin and Rosuvastatin on Atherosclerosis Progression Measured by Carotid Intima Media Thickness ...
The National Institutes of Health Stroke Scale (NIHSS), the CHA2DS2VASC score, and the carotid intima-media thickness (CIMT) ... The National Institutes of Health Stroke Scale (NIHSS), the CHA2DS2VASC score, and the carotid intima-media thickness (CIMT) ... Plasma Dimethylarginine Levels and Carotid Intima-Media Thickness are related to Atrial Fibrillation in Patients with Embolic ... "Plasma Dimethylarginine Levels and Carotid Intima-Media Thickness are related to Atrial Fibrillation in Patients with Embolic ...
Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients ... Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients ... regression of carotid intima-media-thickness (IMT).The impact in patients with advanced atherosclerosis like peripheral artery ... respect to changes of carotid and femoral IMT, changes of patients´ lipid status and occurrence of major adverse cardiovascular ...
The aim of the study was to evaluate the relationship between carotid intima-media thickness (cIMT) and inflammatory markers ... Carotid IMT was significantly correlated to CRP (r = 0.44; p , 0.01), IL-6 (r = 0.42; p , 0.01), TNF-α (r = 0.53; p , 0.01), ...
  • A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque buildup in the walls of the arteries supplying blood to the head. (radiologyinfo.org)
  • If a CIMT shows increased thickness in the inner layers of the carotid artery, you may be at risk for cardiovascular disease. (radiologyinfo.org)
  • CIMT uses ultrasound imaging to measure the thickness of the two inner layers of the carotid artery-called the intima and media. (radiologyinfo.org)
  • A carotid intima-media thickness test (CIMT), also known as a carotid artery IMT ultrasound scan, uses ultrasound to measure the thickness of the intima and media, the two inner layers of the carotid artery . (radiologyinfo.org)
  • Because there is a link between intimal medial thickness and cardiovascular events, CIMT is an important test for detecting disease in its earliest stage, when interventions such as diet, lifestyle, and medications can have the greatest impact. (radiologyinfo.org)
  • Our study examined the association of long-term exposure to traffic with carotid intima-media thickness (cIMT) in 287 healthy children. (hindawi.com)
  • It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. (hindawi.com)
  • We aim to investigate the effect of different doses of recombinant human growth hormone (rhGH) therapy on blood lipid and carotid intima-media thickness (cIMT) in Chinese GHD children. (nature.com)
  • Intima-media thickness of the carotid artery (CIMT) and its increase is associated with several cardiovascular risk factors and manifest cardiovascular diseases. (smw.ch)
  • CIMT is measured in B-mode ultrasound images of the carotid tree as a typical double line of the arterial wall. (smw.ch)
  • CIMT is best visible in the measurement segment of the distal common carotid artery with lowest measurement variability. (smw.ch)
  • Plaques in the carotid tree and thickening of the CIMT are different atherosclerotic processes. (smw.ch)
  • Carotid intima-media thickness (CIMT), recorded with B-mode sonography, is an important marker to quantify atherosclerotic burden in the common carotid artery (CCA). (smw.ch)
  • This cross-sectional study aims at measuring the effect of atherosclerosis assessed through carotid intima-media thickness (CIMT) against plasma VEGF levels in patients with post-acute thrombotic stroke. (dovepress.com)
  • This was an observational study performed in 644 outpatients with type 2 diabetes attending diabetes clinics located in the area of the Campania County, South Italy, who provided complete home blood glucose profiles and centralized carotid intima-media thickness (CIMT) assessment. (nih.gov)
  • CIMT was assessed by carotid sonography. (nih.gov)
  • Carotid Intimamedia thickness (CIMT) is a surrogate marker of atherosclerosis to predict long term cardiovascular outcomes in not only general population but also patients with established coronary artery disease. (clinicaltrials.gov)
  • The National Institutes of Health Stroke Scale (NIHSS), the CHA 2 DS 2 VASC score, and the carotid intima-media thickness (CIMT) were obtained. (mdpi.com)
  • Aim: Carotid intima-media thickness (CIMT) measurements are used as a disease outcome in randomized controlled trials that assess the effects of lipid-modifying treatment. (uva.nl)
  • CIMT progression rates differed across carotid segments with the highest progression rates observed in the bifurcation segment. (uva.nl)
  • Conclusions: Based on the literature, with equal results for reproducibility (assumed), lipid relationship and congruency with event findings, but with treatment effects that differ across carotid segments that can not be predicted, the mean maximum CIMT as the primary outcome may be preferred in trials on the impact of lipid-modifying interventions. (uva.nl)
  • Aim: Ultrasound protocols to measure carotid intima media thickness (CIMT) differ considerably with regard to the inclusion of the number of carotid segments and angles used. (uva.nl)
  • CIMT images were recorded for 12 artery-wall combinations (near and far walls of the left and right common carotid artery (CCA), bifurcation (BIF) and internal carotid artery (ICA) segments) at 4 set angles, resulting in 48 possible measurements per patient. (uva.nl)
  • Objectives: We investigated the association between long-term exposure to black carbon, a correlate of traffic particles, and intima-media thickness of the common carotid artery (CIMT) in elderly men residing in the greater Boston, Massachusetts, area. (harvard.edu)
  • Background Rheumatoid Arthritis (RA) patients are at risk of cardiovascular disease (CVD) and carotid intima media thickness (cIMT) is an excellent marker of subclinical atherosclerosis. (bmj.com)
  • Objectives To assess the carotid intima media thickness (cIMT) in RA patients who were in low disease activity state and lacking concomitant co-morbidities potentially influencing cIMT. (bmj.com)
  • Carotid ultrasound was performed in RA patients and their age and gender-matched healthy controls to determine the cIMT thickness. (bmj.com)
  • We aimed to study the effect of obesity on main carotid artery intima-media thickness (CIMT) and arterial stiffness. (scielo.org.za)
  • Carotid artery intima-media thickness (CIMT) serves as a marker of preclinical atherosclerosis. (scielo.org.za)
  • Exposure to biomass fuel smoke has been associated with lung-mediated inflammation and oxidative stress, which may increase the risk of atherosclerosis as evaluated by carotid intima-media thickness (CIMT), carotid atherosclerotic plaque prevalence and blood pressure. (bmj.com)
  • The main outcome measures were CIMT, carotid plaque and blood pressure. (bmj.com)
  • Here we assessed which potential animal CVD model most closely mimics the serum metabolite signature of increased carotid intima-media thickness (cIMT) in humans, a clinical parameter widely accepted as a surrogate of CVD. (uni-muenchen.de)
  • Data on subclinical atherosclerosis, obtained through assessment of carotid intima-media thickness (CIMT) and presence/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals. (csic.es)
  • Carotid artery intima-media thickness (CIMT) is widely used in observational and intervention studies. (uu.nl)
  • Completeness of CIMT data at different walls, segments and angles of the carotid artery was studied in a population with familial hypercholesterolemia (FH) and in a population with mixed dyslipidemia (MD) in chapter 4. (uu.nl)
  • Pseudoxanthoma elasticum (PXE), caused by mutations in the ABCC6 gene, demonstrates progressive build-up of calcium phosphate and proteoglycans in the skin, eye, and arteries, and is associated to myocardial infarctions, stroke, blindness, and elevated carotid intima-media thickness (CIMT). (jefferson.edu)
  • High carotid intima-media thickness (cIMT) in adulthood was defined as at or above the study visit-, age-, sex-, race-, and cohort-specific 90th percentile of intima-media thickness. (edu.au)
  • This is why I have begun to use carotid intima media thickness (CIMT) measurements as part of my routine workup to screen patients. (ndnr.com)
  • Baseline carotid intima-media thickness (CIMT) is independently associated with extent of atherosclerosis and ischemic cardiovascular events. (termedia.pl)
  • Objective To investigate the efficacy of taking in valsartan hydrochlorothiazide at the different time points on a blood pressure variability( BPV),carotid intima media thickness( CIMT),notric oxide( NO) and endothelin 1( ET-1). (cnki.com.cn)
  • Carotid intima-media thickness (CIMT) measurements are currently widely used in randomized controlled trials (RCTs) to study the efficacy of interventions. (asnjournals.org)
  • Over the past years, many trials have been performed in which carotid intima-media thickness (CIMT) was used as an alternative end point for cardiovascular morbidity and mortality in the study of the efficacy of certain interventions ( 10 - 13 ). (asnjournals.org)
  • Objectives We evaluated whether carotid intima-media thickness (CIMT) and the presence or absence of plaque improved coronary heart disease (CHD) risk prediction when added to traditional risk factors (TRF). (onlinejacc.org)
  • Carotid intima-media thickness (CIMT) is a well-described surrogate marker for cardiovascular disease, and increased CIMT has been associated with prevalent and incident CHD and stroke ( 7,8 ). (onlinejacc.org)
  • Although cigarette smoking has been associated with carotid intima-media thickness (CIMT) the mechanisms are yet not completely known. (pubmedcentralcanada.ca)
  • Aims: We investigated associations of carotid intima-media thickness (CIMT) and carotid plaque with ankle-brachial index (ABI) and toe-brachial index (TBI) in Chinese adults. (eur.nl)
  • CIMT and carotid plaque was measured with a high-resolution B-mode tomographic ultrasound system. (eur.nl)
  • However, no associations were found between CIMT or carotid plaque morphology and TBI or ABI in non-diabetic participants. (eur.nl)
  • Conclusions: CIMT and carotid plaque morphology were significantly associated with TBI in patients with diabetes. (eur.nl)
  • The study aim was to investigate the situations of the carotid Intima-Media Thickness (cIMT) and atherosclerotic plaques in the patients with Cerebral Infarction (CI) as well as their correlations with Plasma protein Z (PZ) and Fibrinogen (FIB). (alliedacademies.org)
  • The aim of this study was to investigate the effect of IBS on HRV parameters, carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of AD, subclinical atherosclerosis and arterial stiffness, respectively. (onlinejacc.org)
  • Carotid intima-media thickness (CIMT) is a marker of cardiovascular risk. (semanticscholar.org)
  • A Carotid Intima Media Thickness Test (CIMT) is a diagnostic test a healthcare provider may recommend which can help detect atherosclerosis and predict your risk for developing several different cardiovascular health conditions. (cardiology-doctors.com)
  • A carotid intima media thickness test, or CIMT scan , is used to measure the thickness of the inner two layers of the carotid artery-the intima and media-to evaluate the artery's overall health, provide early detection for atherosclerosis and determine your risk for cardiovascular disease and the potential of experiencing a stroke. (cardiology-doctors.com)
  • Carotid intima media thickness (CIMT) is a predictor of atherosclerosis which could be measured easily and non-invasively. (panafrican-med-journal.com)
  • The carotid intima media thickness (cIMT) and carotid plaque score (cPS) are respective markers of early and late stage subclinical atherosclerosis. (biomedcentral.com)
  • Carotid intima media thickness (cIMT) is a measure of the intima and media layers of the carotid artery. (biomedcentral.com)
  • Hypertrophy of these intima or media (or both) layers results in a thicker cIMT. (biomedcentral.com)
  • It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. (biomedcentral.com)
  • Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries. (biomedcentral.com)
  • Purpose of this study was to know the association of serum resistin and progression of carotid intima-media thickness (CIMT) in post-ischemic stroke patients. (episirus.org)
  • The carotid Intima-Media Thickness Test (CIMT) is a test that measures the thickness of the two layers of the carotoid artery to determine the risk of heart disease and stroke. (advancedrejuvenationinstitute.com)
  • Carotid Intima Media Thickness (CIMT) is a measurement used to diagnose the extent of carotid atherosclerotic vascular disease. (heartsmarteyecare.com)
  • A CIMT screening measures the thickness of the inner layer of the carotid artery, the intima. (heartsmarteyecare.com)
  • Increased thickness in the intima and media is associated with an increasingly diseased artery . (radiologyinfo.org)
  • The ultrasound device utilizes sophisticated digital imaging and special software to accurately measure the thickness of the inner two layers of the carotid artery and detect plaque, if present. (radiologyinfo.org)
  • In 3 separate analyses, mean carotid artery intima-media thickness (IMT) was regressed on tertiles of (1) burden of all bacteria assessed, (2) burden of bacteria causative of periodontal disease (etiologic bacterial burden), and (3) the relative predominance of causative/over other bacteria in the subgingival plaque. (ahajournals.org)
  • Intima-media thickness was measured in the right and left common carotid artery, bulb, and internal carotid artery. (nih.gov)
  • In borderline hypertensives, an increase in IMT takes place not only in the common carotid artery but also in the bulb and the internal carotid segment. (nih.gov)
  • B-mode ultrasound was used to measure mean and maximum (12 and 36 segments) carotid artery thickness. (cdc.gov)
  • OBJECTIVE -The aim of this study was to assess the association of intima-media thickness (IMT) and arterial stiffness with diabetic retinopathy in an Asian-Indian population that has very high prevalence rates of diabetes and coronary artery disease. (diabetesjournals.org)
  • The measurements were taken on the posterior wall of the right common carotid artery using a standardized protocol. (ebscohost.com)
  • Increased common carotid artery intima-media thickness (IMT) is a marker of atherosclerosis. (ebscohost.com)
  • Background: High Resolution sonography of common carotid artery is a safe method for rapid diagnosis of atherosclerosis in Rheumatoid Arthritis (RA). (ebscohost.com)
  • Flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of the carotid artery are two parameters that can measure subclinical atherosclerosis. (ebscohost.com)
  • Analysis of the population at high risk of stroke detected with carotid artery ultrasonography in Tianjin urban communities. (ebscohost.com)
  • The aim of this study was to investigate the association of blood pressure levels with the common carotid artery intima-media thickness (CCA-IMT) and carotid plaques. (unboundmedicine.com)
  • Furthermore, the usefulness of maximum carotid intima-media thickness (maximum-IMT) as a surrogate marker of coronary artery stenosis was evaluated. (dovepress.com)
  • Does B-mode common carotid artery intima-media thickness differ from M-model? (unboundmedicine.com)
  • An increased intima-media thickness of the common carotid artery is thought to be an early sign of atherosclerosis. (unboundmedicine.com)
  • Both B- and M-mode ultrasonographic techniques are used to measure the intima-media thickness of the common carotid artery (B-IMT and M-IMT, respectively). (unboundmedicine.com)
  • The present study compares intima-media thickness of the common carotid artery measured with the two techniques. (unboundmedicine.com)
  • The carotid bifurcation (CB) into the internal (ICA) and external carotid artery (ECA) is located at the level of the fourth cervical vertebra [1]. (smw.ch)
  • The carotid artery has a superficial course, so that ultrasound examinations usually can be performed without bigger problems. (smw.ch)
  • There are two main methods for measuring common carotid artery intima-media thickness: ultrasound (US) B-mode images (manual, semiautomated or automated) and radiofrequency (RF) multiple M-line analysis (using echo tracking of RF amplitude). (springer.com)
  • Background and Purpose - Increases in the thickness of the intima and media of the carotid artery have been associated with an increased risk of myocardial infarction and stroke in subjects without a history of cardiovascular disease. (ahajournals.org)
  • The present study examines the relationship between vascular risk factors, including carotid artery intima-media thickness (IMT), and lacunar versus nonlacunar infarcts. (ahajournals.org)
  • Patients and 129 control subjects underwent B-mode ultrasonographic measurements of IMT of the common carotid artery. (ahajournals.org)
  • The multinomial logistic regression procedure selected carotid artery IMT and atrial fibrillation as the only independent factors able to discriminate between lacunar and nonlacunar patients. (ahajournals.org)
  • Methods- We recruited 470 white ischemic stroke patients, measured common carotid artery (CCA) IMT, and analyzed 54 polymorphisms with suspected roles in atherosclerosis. (ahajournals.org)
  • Common carotid artery IMT was assessed using high resolution ultrasonography. (ahajournals.org)
  • In a recent study patients with coronary artery disease had a 21% increase in HDL-c and a 13% decrease in triglycerides, and these beneficial effects on lipid status may have contributed to a stabilization or regression of carotid intima-media-thickness (IMT).The impact in patients with advanced atherosclerosis like peripheral artery disease (PAD) in unknown. (centerwatch.com)
  • The intima-media thickness of common, carotid bifurcation, and internal carotid artery were measured using B-mode ultrasound. (biomedsearch.com)
  • Results: Heritability of intima-media thickness was moderately high with estimates (95% confidence intervals) of 0.48 (0.37, 0.59), 0.38(0.27, 0.49), and 0.45(0.34, 0.55) for common, carotid bifurcation, and internal carotid artery, respectively. (biomedsearch.com)
  • The IMTs at the common, bifurcation and internal carotid artery segments, and fasting serum total (TC), LDL (LDLc) and HDL (HDLc) cholesterol, and triglycerides (TG) were determined. (chiro.org)
  • Carotid IMT was a composite measure of the mean IMT in all carotid artery segments. (ahajournals.org)
  • We aimed to study the effect of obesity on main carotid artery lumen diameter and intima-media thickness and the relationships with the early stages of atherosclerosis. (scielo.org.za)
  • Participants completed questionnaires and underwent a clinical assessment, laboratory analyses and carotid artery ultrasound. (bmj.com)
  • In this clinically healthy population of 58-year-old men, CRP levels were associated with both intima-media thickness and plaque occurrence in the femoral artery. (portlandpress.com)
  • Aim: To investigate risk factors which impact on common carotid artery intima media thickness (IMT). (medsci.org)
  • The clinical, biochemical data and the IMT of the common carotid artery were measured in all subjects. (medsci.org)
  • The intima media thickness (IMT) of the common carotid artery (CCA) is a well-known marker of subclinical atherosclerosis and is a noninvasive, feasible, reliable and inexpensive method for detecting development of subclinical atherosclerosis. (medsci.org)
  • O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. (springer.com)
  • We examined whether the National Heart, Lung, and Blood Institute classification of youth non-HDL-C status predicts high common carotid artery intima-media thickness in adulthood. (edu.au)
  • Not only do they have similar risk factors but, more importantly, the relationship between the atherosclerotic burden in a carotid artery and in a coronary artery is the same as between any two coronary arteries. (ndnr.com)
  • Impaired endothelial function and increased carotid intima-media thickness are key events in the atherosclerotic process and predict future cardiovascular events in subjects with and without coronary artery disease. (minervamedica.it)
  • The purpose of this study was to investigate whether the vasodilator response to increased flow in the brachial artery and the presence of carotid lesions may have a prognostic significance for in-stent restenosis in patients undergoing coronary angioplasty. (minervamedica.it)
  • Methods: The Maternal Vascular Adaptation to Healthy Pregnancy Study (Pittsburgh, PA, 2010-2015) assessed 37 primigravid women each trimester, 6-8 weeks after delivery and 1-5 years postpartum, with B-mode ultrasound imaging of common carotid artery (CCA) intima-media thickness (IMT) and inter-adventitial diameter (IAD) to assess associations with physical and cardiometabolic measures. (deepdyve.com)
  • Keywords: Common carotid artery intima-media thickness, Inter-adventitial diameter, Pregnancy, Cardiovascular disease, Vascular remodeling Background risk [1-4]. (deepdyve.com)
  • terial structure-greater intima-media thickness (IMT) These participants were invited to return for a and inter-adventitial diameter (IAD) of the common follow-up visit 1-5 years after their first postpartum carotid artery (CCA)-are associated with greater CVD visit. (deepdyve.com)
  • ABSTRACT This study investigated whether breast arterial calcification (BAC) has an association with coronary artery diseases (CAD) in young premenopausal women and evaluated the association of BAC with carotid intima-media thickness and standard CAD risk factors. (who.int)
  • Among noninvasive diagnostic methods for atherosclerosis, ultrasonography of the carotid artery is useful for measuring intima-media thickness (IMT). (asnjournals.org)
  • B-mode longitudinal US image of the common carotid artery of a 12-year-old boy shows the line drawn by the technologist next to the intima-media-lumen interface indicating the location of the automatic measurement by the M'Ath-Std system software. (springer.com)
  • Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an emerging and independent risk factor for coronary and carotid artery disease [ 7 ], that in animal studies has been shown to be involved in the causal pathway of the intimal oxidative-inflammatory cascade typical of atherogenesis [ 8 ]. (pubmedcentralcanada.ca)
  • 11, 12 However, for a continuous outcome, such as carotid artery intima media thickness (IMT), the linear association can be adequately assessed with fewer numbers. (bmj.com)
  • However, the relationship between genetic polymorphisms of SAA and the intima-media thickness (IMT) of the common carotid artery in healthy subjects remains unclear. (pubmedcentralcanada.ca)
  • Cerebral atherosclerosis mainly occurs in the vessels wider than 500 μm in diameter, and carotid artery is the site frequently involved. (alliedacademies.org)
  • Carotid and popliteal artery B-mode ultrasonographic examinations and hsCRP and fibrinogen levels were analysed at baseline and after a mean of 6.2 months. (journals.co.za)
  • A significant association was observed between dental status, oral hygiene, carotid and popliteal artery intima-media thickness and hsCRP level. (journals.co.za)
  • Patients with increasing DMFT and SLI scores correlated with increasing carotid artery intima-media thickness. (journals.co.za)
  • Objectives To investigate whether external irradiation to the carotid area has any effect on IMT of the common carotid artery in a group of patients who received RT vs control group matched for age, gender and race. (youscribe.com)
  • Conclusion This study shows that increased IMT of the common carotid artery after RT is radiation-dose-related. (youscribe.com)
  • Noninvasive detection of increased carotid artery temperature in patients with coronary artery disease predicts major cardiovascular events at one year: Results from a prospective multicenter study. (semanticscholar.org)
  • Atherosclerosis may cause partial or total blockage of blood flow through arteries in the heart, brain, pelvis, legs, arms or kidneys, and increases your risk of developing such health conditions as coronary heart disease, angina (chest pain), carotid artery disease, peripheral artery disease (PAD) and chronic kidney disease. (cardiology-doctors.com)
  • To schedule a carotid artery scan with a qualified healthcare provider in Midland Park , call (201) 806-6099 or contact Dr. M.T. Shahab online . (cardiology-doctors.com)
  • Studies show that carotid plaque volumes more accurately estimate a patient's risk of coronary artery disease as well as stroke. (cardiology-doctors.com)
  • A gel-like substance will be applied to your skin above the site of each carotid artery, after which an ultrasound probe will be gently placed to both sides of your neck (to visualize carotid arteries on both sides of your neck). (cardiology-doctors.com)
  • To examine the long-term effect of CPAP on carotid artery intima-media thickness (IMT) in patients with Obstructive sleep apnea syndrome(OSAS). (biomedcentral.com)
  • Carotid artery IMT at baseline, 6 months, and 12 months were 758(30), 721(20), and 705(20)micron for the CPAP group versus 760(30), 770(30), and 778(30)micron respectively for the CT group, p = 0.002. (biomedcentral.com)
  • Among those free of cardiovascular disease(n = 24), the carotid artery IMT at baseline, 6 months and 12 months were 722(40), 691(40), and 659(30)micron for the CPAP group (n = 12) with usage 4.5(0.7) and 4.7(0.7) hrs/night over 6 months and 12 months whereas the IMT data for the CT group(n = 12) were 660(20), 685(10), and 690(20)micron respectively, p = 0.006. (biomedcentral.com)
  • Reduction of carotid artery IMT occurred mostly in the first 6 months and was sustained at 12 months in patients with reasonable CPAP compliance. (biomedcentral.com)
  • In recent years, carotid artery IMT, measured by B-mode ultrasound, has been shown to be a highly reproducible test and correlate well with traditional vascular risk factors. (biomedcentral.com)
  • Hence it remains unknown whether CPAP can consistently reduce the carotid artery IMT in patients with OSAS or to a greater magnitude over a longer treatment period. (biomedcentral.com)
  • This study examined the long-term effects of CPAP versus conservative treatment (CT) on carotid artery IMT over a period of 1 year. (biomedcentral.com)
  • We conducted a prospective observational study of the treatment effects on carotid artery IMT in patients newly diagnosed with OSAS. (biomedcentral.com)
  • AIM To determine the clinical and dietary predictors of common carotid artery intima media thickness (CCA IMT) in a cohort of subjects with type 1 and type 2 diabetes. (elsevier.com)
  • In conclusion, NAFLD is modestly associated with carotid IMT and coronary artery calcification in a multiethnic population. (elsevier.com)
  • The carotid artery has two layers, the intima and media, and increased thickness of these membranes is an indicator of carotid atherosclerotic vascular disease. (advancedrejuvenationinstitute.com)
  • Aldosterone excess is responsible per se for vascular morphological (wall thickening and carotid artery fibrosis) and functional (central stiffness) damage. (qxmd.com)
  • Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension. (qxmd.com)
  • Carotid intima-media thickness and brachial-ankle pulse wave velocity in patients with and without coronary artery disease. (qxmd.com)
  • A comparative study of arterial stiffness, flow-mediated vasodilation of the brachial artery, and the thickness of the carotid artery intima-media in patients with systemic autoimmune diseases. (qxmd.com)
  • Coronary artery calcification, common carotid artery intima-media thickness and aortic pulse wave velocity in patients on peritoneal dialysis. (qxmd.com)
  • Early detection of a thickening of the carotid artery intima may indicate the need for an aggressive approach to managing the risk factors associated with ocular and systemic vascular disease. (heartsmarteyecare.com)
  • These measurements can help physicians assess the health of the carotid arteries and the risk of cardiovascular disease-related events like heart attacks and strokes , even in asymptomatic patients. (radiologyinfo.org)
  • Subclinical atherosclerosis can be demonstrated by measuring the intima-media thickness (IMT) of the carotid arteries by high-resolution B-mode ultrasonography (US). (ebscohost.com)
  • The sonographic findings of subclinical atherosclerosis in common carotid arteries: Rheumatoid arthritis patients Versus control group. (ebscohost.com)
  • B mode ultrasound images of the right and left common carotid arteries were acquired according to a standardised protocol. (bmj.com)
  • IMT is determined by visualizing the carotid arteries with high-resolution ultrasound, then analyzing the images by computer to accurately measure the thickness. (ahajournals.org)
  • Arteriosclerosis is a general term for conditions in which diffuse thickening and stiffening in mainly large- and medium-sized arteries develop under different conditions. (scielo.org.za)
  • Both the media and intima of the arteries could be involved in the pathology. (scielo.org.za)
  • Mean common carotid IMT was measured using B-mode ultrasound imaging of the right and left carotid arteries by four certified sonographers who used a common protocol. (cun.es)
  • Aims: To investigate the association between intima-media thickness of brachial and common carotid arteries and factors of the coagulation- and fibrinolysis system with diastolic dysfunction in patients with a previous myocardial infarction. (uio.no)
  • B-mode ultrasound of common carotid and brachial arteries and echocardiography were evaluated in all subjects. (uio.no)
  • Calculated intima-media area (cIMa) of the common carotid and brachial arteries and tissue Doppler imaging (TDI) were examined. (uio.no)
  • Conclusions: Diastolic dysfunction is correlated to cIMa of common carotid and brachial arteries, systolic blood pressure and Prothrombin fragment 1+2 in patients with myocardial infarction. (uio.no)
  • Insulin resistance and intima-media thickness in the carotid and femoral arteries of clinically healthy 58-year-old men. (springer.com)
  • Looking at the carotid arteries provides a "window" to the coronary arteries. (ndnr.com)
  • Vascular echography was performed to measure intima media thickness (IMT) of carotid arteries. (minervamedica.it)
  • Conclusions: The Lp(a) levels were not associated with atherosclerosis in the carotid arteries of statin-treated FH patients. (eur.nl)
  • The results clearly showed that chronic poor oral hygiene and tooth loss are related to sub-clinical atherosclerotic changes in the carotid arteries and may be indicative of future progression of atherosclerosis. (journals.co.za)
  • Therefore it is important to monitor IMT, which can be used as an imaging biomarker for early diagnosis of cerebrovascular disease in patients who have had radiotherapy for treatment of cancer of the head and neck and who are at increased risk for accelerated atherosclerosis in carotid arteries. (youscribe.com)
  • If your healthcare provider suspects that you have plaque buildup, a carotid ultrasound (an ultrasound of the carotid arteries in your neck) will be recommended. (cardiology-doctors.com)
  • A carotid ultrasound can confirm the existence of plaque in the arteries to determine a treatment course, especially as it relates to managing risk factors causally related with heart disease and stroke. (cardiology-doctors.com)
  • Carotid IMT was assessed with B-mode Doppler ultrasound from both carotid arteries using images of the far wall of the distal 10 mm of the common carotid arteries at baseline, 6 months and 12 months. (biomedcentral.com)
  • There was no association between serum resistin levels and progression of intima-media thickness of the internal carotid arteries in post-ischemic stroke patients. (episirus.org)
  • Intima-media thickness and corrected integrated backscatter signal of the carotid arteries were evaluated. (qxmd.com)
  • Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall. (medscape.com)
  • Noncoronary atherosclerosis refers to atherosclerotic disease affecting large and medium-sized noncoronary arteries (eg, extracranial cerebrovascular disease, lower extremity occlusive disease, aneurysmal disease). (medscape.com)
  • Morphologic evidence of subclinical atherosclerosis obtained by carotid ultrasonography in patients with Behcet's disease. (ebscohost.com)
  • Objective To investigate the features of carotid atherosclerosis in a population at high risk of stroke in urban communities of Tianjin, so as to provide inspiration for carotid ultrasonography to play a greater role in the prevention and control of stroke. (ebscohost.com)
  • Further studies are required to confirm the benefits and role of carotid ultrasonography in persons with prehypertension. (unboundmedicine.com)
  • RESEARCH DESIGN AND METHODS: Carotid IMT was measured by ultrasonography in 61 patients with type 2 diabetes. (diabetesjournals.org)
  • All children were subjected to physical examination, routine biochemical and haematological analysis, carotid ultrasonography and echocardiographic measurements. (scielo.org.za)
  • Materials and methods: We performed common carotid ultrasonography at baseline and 33 39 months later in 324 consecutive subjects with type 2 diabetes. (endocrine-abstracts.org)
  • The carotid IMT was determined by ultrasonography at the University Hospital in Linköping and at the County Hospital Ryhov, Jönköping, Sweden. (diva-portal.org)
  • Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men. (springer.com)
  • Intima media thickness was measured and the presence of plaque was evaluated by real time B mode ultrasonography (MyLab 70 XVG, Esaote SpA, Genoa, Italy) using 4.0-13.0 MHz linear probe. (alliedacademies.org)
  • Carotid intima-media thickness (IMT) determined by doppler ultrasonography is a good predictor of the presence and severity of CAD [3,4]. (who.int)
  • Carotid intima-media thickness (IMT) was measured by carotid ultrasonography. (biomedcentral.com)
  • The presence of carotid plaque and intima-media thickness were evaluated by ultrasonography. (biomedcentral.com)
  • Carotid ultrasonography can be used to noninvasively identify early-stage atherosclerotic changes in arterial wall. (biomedcentral.com)
  • All participants underwent a routine clinical examination including physical examination, blood biochemical examination and carotid ultrasonography. (biomedcentral.com)
  • This observational study, conducted in a University Hypertension Center, evaluated the carotid wall by 2-D ultrasonography and ultrasonic tissue characterization, and analyzed arterial stiffness by applanation tonometer. (qxmd.com)
  • 1,2 Characteristics of carotid plaque have been associated with stroke risk 3-5 and coronary events 6 in prospective studies. (ahajournals.org)
  • With the growing interest in cardiovascular disease (CVD) risk stratification by combining vascular imaging with conventional risk factors, it is essential to understand the relationship between carotid IMT and plaque and their independent and combined contribution to the risk of coronary as well cerebrovascular events. (ahajournals.org)
  • 7-9 Although higher CRP is associated with atherosclerosis measures such as higher carotid IMT 10,11 and complex plaque, 12,13 we have shown that the association of CRP with stroke is more apparent in the presence of a higher carotid IMT. (ahajournals.org)
  • In the present study, we evaluated the hypothesis that CRP is less predictive of CVD outcomes in the absence of atherosclerosis by investigating the associations of carotid IMT, carotid plaque, and CRP, alone and in combination, with incident myocardial infarction, stroke, CVD death, and all-cause mortality. (ahajournals.org)
  • Serum 25-OHD levels were significantly lower (p = 0.003) in psoriatic patients with carotid atheromatous plaque (22.38 ± 10.23 ng/mL) than in those without (31.74 ± 8.62 ng/mL). (springer.com)
  • Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study. (springer.com)
  • In a multivariate analysis, including all the variables evaluated at baseline, carotid IMT (P=0.02), level of glycemia (P=0.001), a lower FMD (P=0.005) and presence of carotid plaque remained the only variables predictive of restenosis. (minervamedica.it)
  • It has also been shown to correlates with CV events and with carotid plaque and preclinical atherosclerosis (i.e. (ovid.com)
  • 48±15 years) to detect carotid plaques and determine carotid intima-media thickness (C-IMT).Patients with high versus low Lp(a) levels (≤0.3g/L) had similar plaque prevalence (36 and 31%, p=0.4) and C-IMT (0.59±0.12 and 0.59±0.13mm, p=0.8). (eur.nl)
  • carotid plaque morphology: 1.45, 1.01-2.08) in patients with diabetes after adjustments. (eur.nl)
  • However, there have been few reports about the correlation between serum lipid profile with carotid intima-media thickness (IMT) and plaque in Chinese general people. (biomedcentral.com)
  • LDL-C levels, non-HDL-C levels, TC/HDL-C and LDL-C/HDL-C ratios were significantly higher, but HDL-C levels were significantly lower in subjects with carotid plaque than those without it. (biomedcentral.com)
  • 0.001) were significantly associated with the presence of carotid plaque after adjustment of age. (biomedcentral.com)
  • Serum LDL-C/HDL-C ratio represents as an independent index associated with increased carotid IMT and LDL-C combined with HDL-C levels may be useful markers for predicting the presence of carotid plaque in the Chinese general population. (biomedcentral.com)
  • In the present study, we investigated associations between conventional lipid parameters and lipid ratios with carotid IMT and plaque in participants of a health checkup from the general population. (biomedcentral.com)
  • Since the clock for atherosclerosis starts ticking even before the onset of diabetes ( 4 ), it would be of interest to study whether structural changes, such as carotid intima-media thickness (IMT) ( 5 ), and functional changes, such as arterial stiffness ( 6 ), are associated with diabetic retinopathy. (diabetesjournals.org)
  • Relationships of night/day heart rate ratio with carotid intima media thickness and markers of arterial stiffness. (biomedsearch.com)
  • Arterial stiffness was assessed according to carotid intima media thickness, pulse wave velocity, the central and peripheral augmentation index, and the ambulatory arterial stiffness index. (biomedsearch.com)
  • RESULTS: Carotid intima media thickness, central and peripheral augmentation index, and ambulatory arterial stiffness index were negatively correlated to office and ambulatory heart rate and its standard deviation, and positively correlated to the night/day heart rate ratio. (biomedsearch.com)
  • Our results suggest that in healthy subjects without CKD with carotid OD cystatin-C is increased, well reflecting arterial damage also in absence of essential hypertension or CKD. (ovid.com)
  • The aim of this study was to evaluate whether poor oral hygiene is associated with carotid and popliteal arterial intima-media thickness, which is one of the predictors of future progression of sub-clinical atherosclerosis, and high sensitivity C-reactive protein (hsCRP) and fibrinogen levels. (journals.co.za)
  • Ultrasound-measured carotid arterial compliance and stiffness, was expressed as distensibility coefficient and Young's modulus. (elsevier.com)
  • Intima-media thickness and arterial elasticity in hypertensive children: controlled study. (qxmd.com)
  • The authors concluded that the measurement of carotid IMT may be an useful tool to identify asymptomatic subjects with subclinical atherosclerosis not detected by the traditional risk factors evaluation [ 1 ]. (hindawi.com)
  • The objective of this study was to identify clinical variables associated with subclinical atherosclerosis defined by an increased carotid IMT in treated hypertensive women. (hindawi.com)
  • Betel nut use at long duration or high cumulative exposure levels is associated with subclinical atherosclerosis as manifested through carotid IMT. (nih.gov)
  • The present cross-sectional study was performed to determine whether the degree of bone turnover is correlated to carotid intima-media thickness (CCA-IMT), as a marker of subclinical atherosclerosis. (springer.com)
  • To analyze the association between 25-hydroxyvitamin D serum levels and subclinical carotid atherosclerosis (maximal intima-media thickness (MIMT)) in psoriasis patients and controls. (springer.com)
  • Subclinical atherosclerosis defined as endothelial dysfunction, coronary calcification, and increased carotid intima media thickness is related to cardiovascular events independent from blood pressure. (alliedacademies.org)
  • This study sought to determine the associations between plasma lipids (including LDL particle distribution) and subclinical atherosclerosis measured by the common carotid intima-media thickness (IMT) across levels of estimated GFR (eGFR) and to assess whether inflammation modifies these associations. (asnjournals.org)
  • Carotid intima media thickness (IMT) is a marker of subclinical atherosclerosis that can predict cardiovascular events over traditional risk factors. (ucl.ac.uk)
  • Not all the community dwelling individual has the opportunity or necessity of performing a carotid duplex ultrasound to find out the status of subclinical atherosclerosis, so a model based on the characteristics and routine laboratory results may help to identify high risk patients for subclinical atherosclerosis to send out for further analysis. (biomedcentral.com)
  • The aim of this study is to investigate the presence of dyslipidemia, insulin resistance, and subclinical atherosclerosis as indicated by carotid intima media thickness in children with congenital adrenal hyperplasia.Thirty-two children with congenital adrenal hyperplasia (3-17 years) were compared with 32 healthy controls. (sparrho.com)
  • abstract = "Background--There are few longitudinal studies that have comprehensively examined the intima-media thickness (IMT) growth pattern and its determinants among racial population groups. (elsevier.com)
  • Adjusted carotid IMT values were inversely associated with low high-density lipoprotein cholesterol and directly with hypertension in women. (cdc.gov)
  • It has been formerly shown a close relationship between carotid IMT and traditional cardiovascular risk factors such as ageing, hypertension, obesity, dyslipidemia, and diabetes [ 9 ]. (hindawi.com)
  • 3 The aim of the present study was to investigate the relation between exercise induced hypertension and carotid IMT in adult post-coarctectomy patients. (bmj.com)
  • Patients with FMD above the median value showed higher prevalence of hypertension (P=0.002), diabetes (P=0.02) and carotid IMT (P=0.006) than those below the median. (minervamedica.it)
  • Carotid intima-media thickness and plaques were evaluated with a high-resolution B-mode ultrasound. (unboundmedicine.com)
  • or =1.0 mm), and 1.45 (95% CI=1.19-1.77) for carotid plaques. (unboundmedicine.com)
  • The multivariate adjusted odds ratio of low prehypertensives was 1.64 (95% CI=1.21-2.21) for abnormal CCA-IMT, and 1.30 (95% CI=1.04-1.63) for carotid plaques compared with normotensives. (unboundmedicine.com)
  • Background- Carotid atherosclerosis, measured as carotid intima-media thickness or as characteristics of plaques, has been linked to cardiovascular disease (CVD) and to C-reactive protein (CRP) levels. (ahajournals.org)
  • Both carotid intima-media thickness (IMT) and plaques are measures of carotid atherosclerosis. (ahajournals.org)
  • In this study we aimed to find out the relation between vitamin D level and intima media thickness and the presence of atherosclerotic plaques. (alliedacademies.org)
  • We evaluated common carotid IMT and plaques by ultrasound (Philips 5500, 7.5 Hz Probe) together with office Blood Pressure (BP). (ovid.com)
  • Carotid plaques were classified as normal, homogeneous or heterogeneous according to morphology. (eur.nl)
  • The Oral Infections and Vascular Disease Epidemiology Study (INVEST) was specifically designed to study the hypothesis that periodontal infections predispose to accelerated progression of carotid atherosclerosis and incidence of stroke, myocardial infarction, and cardiovascular disease death. (ahajournals.org)
  • Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. (nih.gov)
  • however, few have examined genetic risk factors for the progression of carotid IMT and none has specifically examined subjects with type 2 diabetes. (endocrine-abstracts.org)
  • This study examined the association between single nucleotide polymorphisms in the adiponectin gene and the progression of carotid IMT in patients with type 2 diabetes. (endocrine-abstracts.org)
  • We investigated the relationship between carotid atherosclerosis and CRP and their joint roles in CVD prediction. (ahajournals.org)
  • Sumino H, Ichikawa S, Kasama S et al (2008) Relationship between carotid atherosclerosis and lumbar spine bone mineral density in postmenopausal women. (springer.com)
  • The relationship between carotid intima media thickness and the activity of rheumatoid arthritis. (bmj.com)
  • CONCLUSIONS: Number of MetSyn components was significantly associated with carotid IMT in female but not in male officers. (cdc.gov)
  • Conclusions- The OPN and MCP-1 genes, coding for 2 cytokines with known roles in atherosclerosis, may contribute to increased carotid IMT and warrant further study. (ahajournals.org)
  • Conclusions: Individual cardiovascular risk factors were differentially associated with carotid intima-media thickness by segments and sex. (biomedsearch.com)
  • Conclusions- In older adults, elevated CRP was associated with increased risk for CVD and all-cause mortality only in those with detectable atherosclerosis based on carotid ultrasound. (ahajournals.org)
  • Conclusions: We here demonstrate that higher fasting levels of GH are associated with thicker IMT in the carotid bulb in males. (lu.se)
  • Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were evaluated before and after treatment in both groups. (nih.gov)
  • Extensive in-person cardiovascular risk factor measurements, a carotid scan with high-resolution B-mode ultrasound, white blood cell count, and C-reactive protein values were obtained. (ahajournals.org)
  • Purpose: To evaluate the reproducibility of carotid intima-media thickness measurements using tissue harmonic imaging (THI) sonography between two observers with different levels of experience. (ebscohost.com)
  • To compare intima-media thickness measurements using B-mode ultrasound, radiofrequency (RF) echo tracking, and RF speckle probability distribution in children with normal and increased body mass index (BMI). (springer.com)
  • In summary, this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with type 2 diabetes. (nih.gov)
  • including only outpatients presenting low or intermediate cardiovascular risk according to European SCORE function, demonstrated that 18.4% of these patients were reclassified as high risk due to increased carotid IMT. (hindawi.com)
  • Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. (diabetesjournals.org)
  • We evaluated whether SCI could be a predictor for incident stroke independent of carotid IMT in high-risk patients. (go.jp)
  • Conclusion SCI, similar to carotid IMT, is an independent predictor of stroke and TIA in high-risk patients. (go.jp)
  • Our objective was to assess the size and timing of post-meal glucose peaks in the everyday life of type 2 diabetic patients and the relationship with carotid atherosclerosis. (nih.gov)
  • We sought to explore the genetics of carotid IMT in brain infarction (BI) patients from the GENétique de l'Infarctus Cérébral (GENIC) study. (ahajournals.org)
  • Therefore, the aim of the present randomized controlled trial is to investigate the effects of nicotinic acid (daily dose starting with 500 mg, up to 2000mg) in addition to simvastatin (40 mg daily) versus simvastatin (40mg daily) monotherapy in patients with low serum HDL-C levels and PAD with respect to changes of carotid and femoral IMT, changes of patients´ lipid status and occurrence of major adverse cardiovascular events (MACE). (centerwatch.com)
  • We have reported that psoriatic arthritis (PsA) patients without overt cardiovascular diseases have evidence of premature atherosclerosis as indicated by an increased carotid intima-media thickness (IMT). (bmj.com)
  • AIMS: To explore the association between carotid intima-media thickness (IMT) and the apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio compared with conventional lipids in middle-aged patients with Type 2 diabetes. (diva-portal.org)
  • Evaluation of FMD and carotid IMT may provide important prognostic information in patients undergoing PCI. (minervamedica.it)
  • Intima Media Thickness - IMT) in patients without CKD or known CV risk factors, although these results have not been confirmed by recent studies. (ovid.com)
  • In addition, carotid intima media thickness was significantly higher in patients with valve calcification compared with those without valve calcification. (ovid.com)
  • Atherosclerosis in post-ischemic stroke patients is marked by a thickness of the carotid intima-media. (episirus.org)
  • In patients undergoing OPCAB, preoperative assessment of carotid IMT may help predicting the development of a postoperative composite of cardiovascular morbidity endpoints. (elsevier.com)
  • RESULTS: Among 106 women, the adjusted mean common and maximum(36) carotid IMT were significantly and positively associated with number of MetSyn components. (cdc.gov)
  • Multivariate stepwise regression analyses were used to identify independent predictors of common carotid IMT. (bmj.com)
  • Additive inherited effects contributed 21% and 31% (common and internal carotid, respectively) to the total variance of the intima-media thickness, while measured cardiovascular risk factors accounted for 46% and 26% (common and internal carotid, respectively). (biomedsearch.com)
  • Several studies have shown that common carotid intima-media thickness (IMT) is increased after radiotherapy (RT) to the head and neck. (youscribe.com)
  • Common carotid IMT was measured with echo-color Doppler. (youscribe.com)
  • Meta-analysis of five cohort studies supported a protective effect of the A allele on common-carotid IMT in women only. (ucl.ac.uk)
  • Multivariate linear regression analysis showed the presence of NAFLD was associated with both the common carotid and internal carotid IMT and logCAC. (elsevier.com)
  • Conclusion: The results of this study show that carotid IMT measurement using THI sonography and a standardized protocol is accurate and reproducible. (ebscohost.com)
  • de Groot E, van Leuven SI, Duivenvoorden R et al (2008) Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis. (springer.com)
  • Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness. (edu.au)
  • The increase of carotid IMT has been more commonly associated with development of coronary heart disease and stroke [ 4 , 5 ]. (hindawi.com)
  • reported a meta-analysis showing that the relative risk for stroke and myocardial infarction rises proportionally to the increase of carotid IMT [ 7 ]. (hindawi.com)
  • Background Both silent cerebral infarction (SCI) and carotid intima-media thickness (IMT) are associated with future stroke. (go.jp)
  • We conducted cranial MRI and measured carotid IMT at baseline, and then evaluated the risks of incident stroke and transient ischemic attacks (TIA) using Cox proportional hazards models. (go.jp)
  • Both SCI and carotid IMT at baseline were associated with incident stroke/TIA events after adjustment for age, sex, and traditional vascular risk factors. (go.jp)
  • Increased carotid IMT is a marker of generalized atherosclerosis and is associated with future myocardial infarction and stroke. (ahajournals.org)
  • African Americans tend to have greater carotid intima-media thickness (IMT), and are 60% more likely to have a stroke than Caucasians. (ahajournals.org)
  • The objective of this cross-sectional study was to investigate the relation between HDL2 and HDL3 subfractions and carotid intima-media thickness (IMT), an early indicator of atherosclerosis and surrogate marker of ischemic stroke. (ahajournals.org)
  • Frequency and duration of betel nut use were assessed at baseline, and carotid IMT was measured on average 6.65 years after baseline. (nih.gov)
  • All participants underwent baseline clinical examinations, which included medical history, physical examination, and carotid ultrasound. (ahajournals.org)
  • Background and Purpose- Carotid intima-media thickness (IMT) reflects generalized atherosclerosis and is predictive of future vascular events. (ahajournals.org)
  • However, we could not demonstrate any changes in vascular structure and functions measured by carotid intima-media thickness and pulse wave velocity. (onlinejacc.org)
  • Factors underlying the increase in carotid intima-media thickness in borderline hypertensives. (nih.gov)
  • The present work is aimed at assessing the association between cystatin-C and carotid atherosclerosis in a population free of CKD and CV diseases. (ovid.com)
  • After adjusting for age, sex, heart rate, BMI, smoking, serum cholesterol, triglycerides, and physical activity, higher values of m-IMT and M-IMT were present in most carotid segments of borderline hypertensives compared with controls. (nih.gov)
  • In the various carotid segments, the prevalence of raised lesions was 1. (nih.gov)
  • The additive genetic cross-trait correlations between the segments ranged between 0.43 and 0.75, suggesting a shared genetic influence on the three carotid segments. (biomedsearch.com)
  • Treatment effects differed across carotid segments without a clear preference pattern. (uva.nl)
  • Conclusion: Variation in the adiponectin gene is associated with the rate of carotid IMT progression and is an important genetic factor for the progression of atherosclerosis in subjects with type 2 diabetes. (endocrine-abstracts.org)
  • Examine the relation between consumption of low-fat vs. whole-fat dairy products with the carotid intima-media thickness and pulse wave velocity. (biomedcentral.com)
  • The mean carotid IMT increased with increasing doses of radiation to the neck (p = 0.04). (youscribe.com)
  • To investigate the role of pTG levels in atherosclerosis, we examined the correlation between pTG levels and carotid intimal-medial thickness (IMT). (diabetesjournals.org)
  • Endothelial dysfunction but not increased carotid intima-media thickness in young European women with endometriosis. (semanticscholar.org)
  • 0.01) thicker intima media (0.69mm, 0.66mm) as compared to the control group (0.38mm), but there was no significant difference of IMT between obese and MetS group. (medsci.org)
  • We did not find any relation between vitamin D level andintima media thickness in hypertensive subjects. (alliedacademies.org)
  • In children, increased intima-media thickness is associated with obesity and the risk of cardiovascular events in adulthood. (springer.com)
  • Other risk factors including age and systolic blood pressure were independently associated with carotid IMT. (biomedcentral.com)
  • High HDL cholesterol level after treatment with pitavastatin is an important factor for regression in carotid intima-media thickness. (sigmaaldrich.com)
  • We selected 50 outpatients (mean age 71.7 ± 12.3), underwent to eco-Doppler evaluation of extracranial carotid tract, without history of calcium and/or vitamin D supplementation, or antireabsorptive therapy. (springer.com)
  • Quantitative genetic and linear mixed analyses were performed to examine inherited and environmental contributions to intima-media thickness variation. (biomedsearch.com)
  • Our results indicate that there is a significant increase in the prevalence of carotid atherosclerosis in subjects with prehypertension (even in low prehypertensives) compared with normotensive subjects. (unboundmedicine.com)
  • in the case of office heart rate, the peripheral augmentation index decreased 4.74 (95%CI: 3.15-6.33) and central augmentation index decreased 3.52 (95%CI: 2.43-4.30), while for 24h standard deviation heart rate, carotid intima media thickness decreased 0.03mm (95%CI: 0.01-0.06). (biomedsearch.com)
  • 0.01) were associated with progressive carotid IMT. (endocrine-abstracts.org)
  • American Society of Echocardiography Carotid Intima-Media Thickness Task Force (2008). (wikipedia.org)
  • Results: In MDC-CC fasting values of GH exhibited a positive cross-sectional relation to the IMT at the carotid bulb independent of traditional cardiovascular risk factors (p = 0.002). (lu.se)
  • Metabolic syndrome and carotid intima media thickness in urban police officers. (cdc.gov)
  • OBJECTIVE: To examine the association between metabolic syndrome (MetSyn) and carotid intima media thickness (IMT) separately in male and female police officers. (cdc.gov)
  • Here we investigated whether sCD93, a group XIV c-type lectin of the endosialin family, plays a role in metabolic dysregulation or carotid intima-media thickness (IMT). (diabetesjournals.org)
  • Our preliminary study showed that 6 months of diet and exercise intervention reduced carotid IMT by ∼7.3% and improved the cardio-metabolic profile in sedentary African Americans. (ahajournals.org)
  • One hundred and seventy-one Chinese male vegetarians were screened for metabolic profile, cardiovascular risk and carotid IMT. (biomedcentral.com)
  • 3) to assess the usefulness of combined carotid and femoral. (ebscohost.com)
  • We evaluated the associations between natural dietary intake of PS and carotid intima-media thickness (IMT) and serum lipids. (chiro.org)
  • The level of serum resistin was determined and carotid duplex ultrasound was performed on subject. (episirus.org)
  • To define the role played by various risk and behavioral factors in the increase of carotid intima-media thickness (IMT) observed in borderline hypertensives. (nih.gov)
  • Blood pressure levels are a main determinant of m-IMT while the interaction of BP with other risk factors such as age and plasma lipids is more relevant for advanced intima-media thickening such as M-MAX. (nih.gov)
  • The use of intima-media thickness in risk stratification, however, is limited by two factors. (springer.com)
  • Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: the Healthy Twin Study. (biomedsearch.com)
  • Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. (biomedsearch.com)
  • This study aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media thickness. (biomedsearch.com)
  • Addition of CRP or carotid atherosclerosis to conventional risk factors modestly increased in the ability to predict CVD, as measured by the c statistic. (ahajournals.org)
  • Despite the significant associations of CRP and carotid atherosclerosis with CVD, these measures modestly improve the prediction of CVD outcomes after one accounts for the conventional risk factors. (ahajournals.org)
  • 10 Whether the association of CRP with CVD risk is modified by the presence of carotid atherosclerosis has not been explored fully. (ahajournals.org)
  • Risk factors diagnosed in childhood can predict the development of preclinical carotid atherosclerosis in adults. (scielo.org.za)
  • To assess the association between the intake of dietary fibre and carotid intima-media thickness (IMT) in a Mediterranean population at high cardiovascular risk. (cun.es)
  • Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. (bmj.com)
  • Carotid IMT is a valid indicator of CHD risk. (bmj.com)
  • A carotid ultrasound uses soundwaves to detect and quantify the development of atherosclerosis before symptoms present, also indicating your risk for the condition. (cardiology-doctors.com)
  • Carotid intima media thickness and other cardiovascular risk factors in children with congenital adrenal hyperplasia. (sparrho.com)