Carotid Intima-Media Thickness: A measurement of the thickness of the carotid artery walls. It is measured by B-mode ULTRASONOGRAPHY and is used as a surrogate marker for ATHEROSCLEROSIS.Tunica Intima: The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.Tunica Media: The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.Carotid Arteries: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.Carotid Artery, Common: The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Endarterectomy, Carotid: The excision of the thickened, atheromatous tunica intima of a carotid artery.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Carotid Artery Injuries: Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Carotid Body: A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Plaque, Atherosclerotic: Lesions formed within the walls of ARTERIES.Body Mass Index: An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Arteries: The vessels carrying blood away from the heart.Carotid Sinus: The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Carotid Artery, External: Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.Aorta: The main trunk of the systemic arteries.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Neointima: The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Carotid Artery Thrombosis: Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Calcinosis: Pathologic deposition of calcium salts in tissues.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Rats, Inbred SHR: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Recombinant human interleukin-10 inhibits proliferation of vascular smooth muscle cells stimulated by advanced glycation end products and neointima hyperplasia after carotid injury in the rat. (1/431)

The purposes of this study was to determine the effects of recombinant human interleukin-10 (rhIL-10) on proliferation of vascular smooth muscle cells (VSMCs) stimulated by advanced glycation end products (AGE) and neointima hyperplasia after rat carotid arterial injury. Rat aortic VSMCs were cultured and treated with rhIL-10 or AGE respectively, and then co-treated with rhIL-10 and AGE. Proliferation of VSMCs was quantified by colormetric assay. Cell cycle analysis was performed by flow cytomertry. Sprague-Dawley rats were treated with recombinant human IL-10 (rhIL-10) for 3 d after carotid arteries injury. The ratio of neointima to media area at the site of arterial injury was measured 28 d after balloon injury. The p44/42 MAPK activity was evaluated by the immunoblotting technique using anti-p44/42 phospho-MAPK antibody. Compared to control, AGE stimulated VSMCs proliferation. rhIL-10 alone had no effect on VSMCs growth. With AGE stimulation, rhIL-10, at dose as low as 10 ng/ml, inhibited VSMCs growth (P<0.05). The cell number in G(0)/G(1) phase of AGE and rhIL-10 co-treatment group was higher than that of AGE treatment alone (P<0.01) by flow cytometry analysis. Compared with the control group of neointima hyperplasia in rats, the ratio of neointima to media area of recombinant human IL-10 group was reduced by 45% (P<0.01). The p44/42 MAPK activity was significantly enhanced by AGE. The AGE effects were opposed by rhIL-10. The anti-inflammatory cytokine rhIL-10 inhibits AGE-induced VSMCs proliferation. Recombinant human IL-10 also inhibited neointima hyperplasia after carotid artery injury in rats. The results suggest the possibility that recombinant human IL-10, as a potential therapeutic approach, prevents neointimal hyperplasia.  (+info)

Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis. (2/431)

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Physical exercise, fitness and dietary pattern and their relationship with circadian blood pressure pattern, augmentation index and endothelial dysfunction biological markers: EVIDENT study protocol. (3/431)

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Medical decision-making system of ultrasound carotid artery intima-media thickness using neural networks. (4/431)

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The age correlation of the carotid intima-media thickness according to sex and side in asymptomatic subjects. (5/431)

PURPOSE: Reports concerning carotid intima-media thickness (CIMT) and linear correlation to age in healthy subjects did not distinguish the side and sex of the subjects. The purpose of this investigation attempts to clarify these issues. METHODS: 2402 asymptomatic persons, age 35-64, are separated into men's left (Lt) and right (Rt) and women's Lt and Rt carotid arteries for difference of CIMT between them and analysis of CIMT vs. age. RESULTS: There are significant difference between men's CIMT of Lt(CIMTML) vs Rt (CIMTMR), women's Lt(CIMTWL) vs. Rt (CIMTWR), Lt side CIMT of men vs women, and Rt side CIMT of men vs. women. The regression equation of CIMT vs. age for all four groups is determinated. CONCLUSION: We found an excellent linear correlation of CIMT to age and CIMT is significantly higher in men than women, so as higher in Lt than Rt. Further grouping of data into about 5-year period showed more clearly stepwise increasing of CIMT, so as the ratios of Lt CIMT different than Rt. CIMT study is served as highly efficient examination in therapy, prevention, clinic, or research survey about atherosclerosis and risk of stroke. Future study design concerning CIMT in separation groups of men and women, so as Lt and Rt is highly recommended.  (+info)

Atherogenic lipid profile and systolic blood pressure are associated with carotid artery intima-media thickness in children with Turner syndrome. (6/431)

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Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans. (7/431)

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Real-time co-registration using novel ultrasound technology: ex vivo validation and in vivo applications. (8/431)

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*Intima-media thickness

Intima Media Thickness) and its utility Various Newscasts on Carotid IMT (Intima Media Thickness) Bortel L (2005). "What does ... Although carotid intima-media thickness is strongly associated with atherosclerosis, thickening of the intima-media may not ... Intima-media thickness (IMT), also called intimal medial thickness, is a measurement of the thickness of tunica intima and ... Bots ML (2006). "Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies". Curr ...

*Society for Vascular Medicine

American Society of Echocardiography Carotid Intima-Media Thickness Task Force (2008). "Use of Carotid Ultrasound to Identify ... A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the ...

*Complications of hypertension

Riccioni G (2009). "The effect of antihypertensive drugs on carotid intima media thickness: an up-to-date review". Current ... Persistently elevated blood pressure leads to intimal thickening, hyperplasia of the media wall, and hyaline degeneration in ...

*Cardiology

Riccioni G (2009). "The effect of antihypertensive drugs on carotid intima media thickness: an up-to-date review". Current ... Play media Essential hypertension is the form of hypertension that by definition has no identifiable cause. It is the most ...

*HLA-DR17

"Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives". Am J ...

*TMCO5A

"Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray". ...

*5-lipoxygenase-activating protein

"Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study". Stroke: A ...

*Torcetrapib

July 2007). "Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double- ... following media and physician criticism, Pfizer had subsequently planned for torcetrapib to be sold independently of Lipitor. A ... http://clinicaltrials.gov/ct2/show/NCT00136981 Phase III Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect ...

*ZC3HC1

Furthermore, rs11556924 has also been associated with altered carotid intima-media thickness in patients with rheumatoid ... "The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid ...

*Silent stroke

2010). "Silent cerebral infarction is associated with incident stroke and TIA independent of carotid intima-media thickness". ...

*Atherosclerosis

Provost, EB; Madhloum, N; Int Panis, L; De Boever, P; Nawrot, TS (2015). "Carotid intima-media thickness, a marker of ... Examples of anatomical detection methods include coronary calcium scoring by CT, carotid IMT (intimal media thickness) ... "Fine Particulate Air Pollution and the Progression of Carotid Intima-Medial Thickness: A Prospective Cohort Study from the ... Carotid arteries supply blood to the brain and neck. Marked narrowing of the carotid arteries can present with symptoms such as ...

*Study of Health in Pomerania

Relation of parity with common carotid intima-media thickness among women of the Study of Health in Pomerania (SHIP). Stroke ... Thyroid function and carotid wall thickness. J Clin Endocrinol Metab 2004;89:2145-2149 Völzke H, Werner A, Wallaschofski H, ... Association between high serum ferritin levels and carotid atherosclerosis in the Study of Health in Pomerania (SHIP). Stroke ...

*Pitavastatin

... and Carotid Intima-Media Thickness in Patients with Dyslipidemia". Journal of Atherosclerosis and Thrombosis. 22: 1158-1171. ...

*Arachidonate 5-lipoxygenase

... as judged by carotid intima-media thickness measurements. Variant alleles involved deletions (one or two) or additions (one, ...

*Bergamot orange

Subclinical atherosclerosis, which was assessed by carotid intima-media thickness, was also reduced significantly over a ...

*Albert Hofman

Common carotid intima- media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012 Aug 22;308(8 ...

*Lysophosphatidylcholine

"Lysophosphatidylcholine and Carotid Intima-Media Thickness in Young Smokers: A Role for Oxidized LDL-Induced Expression of PBMC ...

*Hypermagnesemia

Significantly lower values of carotid intima-media thickness and aortic pulse wave velocity values, which are surrogate markers ... Play media Weakness, nausea and vomiting Impaired breathing Decreased respirations Low blood pressure Low blood calcium ...

*Atheroma

Carotid Intima-media thickness Scan (CIMT can be measured by B-mode ultrasonography) measurement has been recommended by the ... Promising results are found using carotid intima-media thickness scanning (CIMT can be measured by B-mode ultrasonography), B- ... which have supported a direct correlation of Carotid Intima-media thickness (CIMT) with myocardial infarction and stroke risk ... Arterial ultrasound, especially of the carotid arteries, with measurement of the thickness of the artery wall, offers a way to ...

*Ezetimibe/simvastatin

... in terms of achieving a lower change from baseline in carotid intima-media thickness despite lower LDL levels in a population ... News and Media - News Releases Park, Alice (2008-01-15). "Is Vytorin a Failure?". Time. Retrieved 2010-05-02. Vytorin Results ...

*Wolfgang Patsch

... established and candidate risk factors in well characterized populations using the intima-media thickness of the common carotid ... Association of postprandial triglyceride and retinyl palmitate responses with asymptomatic carotid artery atherosclerosis in ...

*Periodontitis

"Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness : The Atherosclerosis Risk in Communities ( ...

*Common carotid artery

Carotid stenosis may occur in patients with atherosclerosis. The intima-media thickness of the carotid artery wall is a marker ... Provost, E; Madhloum, N; Int Panis, L; De Boever, P; Nawrot, T (2015). "Carotid Intima-Media Thickness, a Marker of Subclinical ... Common carotid artery Right and left common carotid arteries Head and neck anatomy Carotid sheath Carotid sinus Carotid body ... Common carotid artery - right view Brachial plexus and common carotid artery Common carotid artery ...

*John David Spence

Spence pioneered the use of carotid plaque measurement (as opposed to intima-media thickness) for research and for management ... Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy Stroke. 2002;33:2916-2922 Stroke 1986; 17( ... Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy Stroke. 2002;33:2916-2922 Stroke 1999;30: ... The effect of drug therapies on carotid plaque volume can now be evaluated in a very cost-effective way. Development of ...

*Chronic endothelial injury hypothesis

2001). "Oxidized LDL and thickness of carotid intima-media are associated with coronary atherosclerosis in middle-aged men: ... The formation of foam cells and their continued accumulation in the intima lead to the formation of fatty streaks. Continued ... Leukocytes migrate to the subendothelial space and aggregate within the intima. In the presence of elevated levels of oxidized ... cells to secrete molecules that cause monocytes to penetrate between the endothelial cells and accumulate in the intima. ...

*Artery

Inside this layer is the tunica media, or media, which is made up of smooth muscle cells and elastic tissue (also called ... These are followed by the branches off the aortic arch, namely the brachiocephalic artery, the left common carotid, and the ... commonly called the intima. This layer is mainly made up of endothelial cells. The hollow internal cavity in which the blood ... arteries are surrounded by varying thicknesses of smooth muscle which have extensive elastic and inelastic connective tissues. ...
The triple line pattern on carotid intima media thickness imaging and its relationship to cardiovascular risk factors in patients on lipid lowering therapy Tania A Singh,1 Todd C Villines,2 Allen J Taylor31Division of Cardiology, Medstar Georgetown University Hospital, 2Walter Reed National Military Medical Center, Bethesda, MD, 3Georgetown University School of Medicine, Washington, DC, USA Background: Carotid intima media thickness (CIMT) infrequently identifies a triple line pattern (TLP) in the visualization of the internal elastic lamina. We examined the prevalence and predictors of the TLP among a consecutive series of subjects enrolled in a CIMT clinical trial, and also the effects of lipid lowering therapy.Methods: Baseline CIMT studies of subjects with known heart disease, or high risk for heart disease, were evaluated from a single site of the Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis trial (N
Vascular morbidity and mortality due to cardiovascular disease (CVD) are high after ischemic stroke at a young age. Data on carotid intima-media thickness (cIMT) as marker of atherosclerosis are scarce for young stroke populations. In this prospective case-control study, we examined cIMT, the burden of vascular risk factors (RF) and their associations among young and middle-aged ischemic stroke patients and controls. We aimed to detect clinical and sub-clinical arterial disease. This study was conducted in 150 patients aged 15-60 years and 84 controls free of CVD. We related RF to ultrasonographic B-mode cIMT-measurements obtained from 12 standardized multiangle measurements in the common carotid artery (CCA), carotid bifurcation (BIF) and internal carotid artery (ICA). RF burden was higher among patients than among controls (p | 0.001). In multivariate analyses of all 234 participants, increased cIMT was associated with age in each carotid segment. Incident stroke was associated with increased ICA-IMT.
Carotid intima-media thickness (CIMT) is associated with an increased risk of cardiovascular disease. We studied whether CIMT predicts the prognosis of Asian patients with acute ST-elevation myocardial infarction (STEMI). A total of 345 patien
Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media thickne
To the Editor:. We congratulate Lorenz et al1 on their review of carotid intima-media thickness (IMT). The authors acknowledged that the heterogeneity among IMT measurement methodologies and study populations are the most important limitation of their metaanalysis. It is surprising however that the paper lacks discussion regarding the prognostic importance of the presence of carotid plaque. Moreover, no information was provided on plaque prevalence or on the effect that incorporation of plaque into IMT measurements likely had on the results.. Carotid plaque is a distinctive phenotype of atherosclerosis that poses a higher likelihood of rupture, thrombosis, rapid progression, responds to factors that affect endothelial function, and represents remodeling to minimize flow disturbances.2 In contrast, IMT principally represents hypertensive hypertrophy of the media and is under a substantial genetic control different from that of plaque.2 Carotid plaque most likely is not a simple continuum of IMT ...
OBJECTIVE: Carotid intima-media thickness (cIMT) is a surrogate marker of subclinical atherosclerosis and it is able to predict both coronary and cerebral vascular events. No data exist on the association between cIMT and non valvular atrial fibrillation (NVAF) type. We conduct this study with the aim to analyze the association between abnormal cIMT and NVAF type. METHODS: A cross-sectional study of the Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) has been performed. Among 2027 patients enrolled in the ARAPACIS, 673 patients, who underwent carotid ultrasound examination to assess cIMT, were included in the study. RESULTS: Among the entire population, 478 patients (71%) had cIMT , 0.90 mm. Patients with an abnormal cIMT (,0.90 mm) were significantly older and more likely hypertensive, diabetic and with a previous history of stroke than those with normal cIMT (≤0.90 mm). These patients had more permanent/persistent NVAF and ...
Based on sample participants and measurement protocols, we assessed the reliability of CIMT and plaque presence between three clinical centers. We regarded an ICC in the range 0.4-0.75 as fair to good and , 0.75 as excellent [21]. In our results, the mean CIMT values had an excellent range of ICC, while the maximum CIMT values had a fair to good range. It is probably because the mean CIMT value is less affected by an outlier than the maximum value. We attribute these results to our protocol that allows adding the plaque thickness to CIMT if plaque exists in distal CCA. This tendency was consistent with the results from other articles [14,17]. Spearman correlation showed similar tendency, too. We could not conclude the rating of each center due to the lack of absolute right CIMT value, but from these results, center 3 was likely to provide a highly reliable value. In the separate analysis done by right and left carotid arteries, only the mean CIMT value of right carotid artery had an ...
Background and aims: Previous studies have documented environmental risk factors for the progression of carotid intima-media thickness (IMT); however, few have examined genetic risk factors for the progression of carotid IMT and none has specifically examined subjects with type 2 diabetes. This study examined the association between single nucleotide polymorphisms in the adiponectin gene and the progression of carotid IMT in patients with type 2 diabetes.. Materials and methods: We performed common carotid ultrasonography at baseline and 33 39 months later in 324 consecutive subjects with type 2 diabetes. The genotypes of the adiponectin gene were determined using a single base primer extension method.. Results: The A allele of −11426A/G (P,0.05), G allele of −10066C/G (P=0.001), A allele of −8564G/A (P,0.01), A allele of −450A/G (P,0.05), and G allele of 276G/T (P,0.01) were associated with progressive carotid IMT. In the haplotype analysis, the AC/AC haplotype combination in block 1, ...
Introduction: HDL-cholesterol (HDL-c) is a strong, traditional negative cardiovascular (CV) risk factor. However, some reports suggest that extremely elevated HDL-c, i.e. hyperalphalipoproteinemia (HALP), may mark dysfunctional HDL particles, paradoxically conferring increased CV risk. Moreover, therapies aimed to increase HDL-c levels through CETP inhibition failed to demonstrate CV risk reduction despite substantial increase in HDL-c. Carotid Intima-Media Thickness (cIMT) is a reliable surrogate for atherosclerotic disease, validated for CV risk assessment. We studied cIMT among individuals with HALP.. Hypothesis: We assessed the hypothesis that HALP is independently associated with lower cIMT when compared with HDL-c levels on usual normal range.. Methods: The Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) enrolled 15,105 subjects aged 35-74 years between 2008-10 for long-term follow-up, which included IMT measurements in both common carotid arteries and assessment of lipid ...
Introduction: Increased Carotid intima-media thickness (CIMT) has been shown to be predictive of future cardiovascular events in middle-age and older adults, with this outcome being detrimentally enhanced by increased body adiposity -as measured by Body Mass Index (BMI).. Hypothesis: We assessed the hypothesis that the association between BMI and CIMT varies among race (black/white) and gender groups.. Methods: B-mode ultrasound images of the far walls for both carotid arteries were obtained from 676 community-based subjects, aged 24 to 43 years, enrolled in the Bogalusa Heart Study (70% white and 43% male). CIMT, BMI and traditional cardio metabolic (CM) risk factors were measured at baseline, and a second set of CIMT imaging was performed at follow-up after an average of 6.9 years. Composite CIMT was considered for the analyses. Progression of IMT was defined as an increase of IMT between examinations, that was greater than the upper endpoint of the 95% confidence interval of the mean ...
The renin-angiotensin-aldosterone system can be activated by sympathetic nervous input and is thought to have an important role in the prevalence of hypertension and cardiovascular risk in black Africans. We examined (1) the association between plasma renin responses to mental stress and a marker of sub-clinical atherosclerosis; and (2) associations between resting renin and 24-h ambulatory blood pressure. Participants were 143 urbanized black African men and women (43.1±7.7 years) drawn from a study of Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA). After an overnight fast, participants completed the Stroop mental stress task. Blood samples were drawn during baseline and 10 min after the task to assess the concentration of active renin in plasma. Blood pressure assessments included continuous Finometer measures during the stress testing and 24-h ambulatory monitoring. Carotid intima-media thickness (CIMT) was measured using high-resolution ultrasound. Approximately 50% ...
Carotid intima-media thickness (IMT) is a measure of arterial thickening and a risk predictor for myocardial infarction and stroke. It is unclear whether IMT also predicts atrial fibrillation (AF). We explored the association between IMT and incidence of first AF hospitalization in a population-based cohort ...
A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque buildup in the arteries supplying blood to the head. Learn more.
Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or ...
Comparison of the effect on the progression of the carotid intima-media interphase thickness (GIM), arterial rigidity according to the measurement of the pulse wave speed and direct measurement of the carotid and aortic rigidities and an inflammation marker (PCR) in patients with established cardiovascular disease (myocardial infarct, atherosclerotic coronary disease), diabetes mellitus type 2 or equivalent risk of coronary disease and a low density lipoprotein level , 100 mg/dL, treated with simvastatin, pravastatin or the combination of simvastatin-ezetimibe during a period of at least one year ...
Background: The most common cause of mortality in people with diabetes is cardiovascular disease. The relation between glycosylated hemoglobin (HbA1c), a marker of glycemic control, and the development of subclinical atherosclerosis is debated. An acceptable indicator of subclinical atherosclerosis is the use of ultrasound to measure carotid intima-media thickness (CIMT). Objective: To conduct a cross-sectional study exploring the correlation between HbA1c and subclinical atherosclerosis as reflected by the carotid intima-media thickness in patients with type 2 diabetes that had no history of an atherosclerotic cardiovascular disease (ischemic heart disease or cerebrovascular accident). Methods: A total of 71, type 2 diabetic patients participated in this study. Demographic, anthropometric and laboratory measures of the participants were collected. CIMT values were measured by using a high-resolution ultrasound. Increased CIMT values were accepted as |0.9 mm. Participants were categorized into two
Methods and Results: To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables considering the whole carotid tree (IMTmean, IMTmax, and IMTmean-max), were analyzed. A replication stage investigating 42 single-nucleotide polymorphisms for association with common carotid IMT was undertaken in 5 independent European cohorts (total n=11 590). A locus on chromosome 16 (lead single-nucleotide polymorphism rs4888378, intronic in CFDP1) was associated with cIMT at significance levels passing multiple testing correction at both stages (array-wide significant discovery P=6.75×10 -7 for ...
In this study, we identified and replicated TRAF1 (lead SNP rs2416804) on chromosome 9 to be linked and associated with CIMT (pooled P=6.02×10-7). We additionally identified 2 genomic regions on chromosomes 4 and 17 with suggestive linkage to CIMT, which have not been reported before. Finally, we could replicate previously reported linkage findings on chromosomes 13 and 14.. Our combined linkage and association analysis identified a SNP in TRAF1 on chromosome 9, as well as a cluster of SNPs on chromosome 6. TRAF proteins mediate the signal transduction from receptors of the tumor necrosis factor receptor and were detected in plaques from atherosclerotic lesions.31 A genome-wide association study and a candidate gene study identified TRAF1 as susceptibility genes for rheumatoid arthritis (RA).32,33 RA is associated with increased mortality, largely as a consequence of coronary artery disease. It was, thus, hypothesized that inflammation associated with RA contributes to accelerated ...
Moon et al conducted a 5-year cohort study to know the association between carotid atherosclerosis and progression of cognitive impairment in 348 older adults.1 Cognitive function was assessed using standard test batteries, and carotid atherosclerosis was determined by ultrasonographic measurement of intima-media thickness (IMT) and plaque formation in the carotid artery. The authors adopted multivariate logistic regression analyses for predicting the progress of cognitive impairment or mild cognitive impairment by adjusting age, education, mood, and general health status. Odds ratio (95% confidence interval) of baseline mean carotid IMT for subsequent progression of cognitive impairment and mild cognitive impairment in subjects with normal baseline cognition were 1.251 (1.006-1.555) and 1.325 (1.045-1.679), respectively. In contrast, carotid plaque did not significantly contribute to cognitive impairment after full adjustment. I have some queries on their study.. First, the authors handled ...
Our study showed that in our sample, patients with type 1 diabetes had a higher IMT compared with the control subjects. Despite having type 1 diabetes for a relatively long time, our patients with type 1 diabetes had a lower IMT than expected, similar to the findings of another study [13]. In our study, in patients with type 1 diabetes, having a family history of type 2 diabetes was associated with a 4.4% increase in carotid IMT and unlike the control group, women with type 1 diabetes had a IMT as high as men.. In the control group, the female gender was associated with a thinner IMT, but this association was not found in our patients with type 1 diabetes. A study that evaluated the distribution of IMT according to age in the general population showed that men had a higher IMT compared with women [39]. These findings could reflect a loss of gender protection for CVD risk in women with type 1 diabetes as suggested by The Diabetes UK Cohort Study and another study [40, 41]. In fact, in patients ...
Background: Type 2 diabetes is a common disease with increased mortality and morbidity due to cardiovascular disease (CVD). This thesis is based on three studies that evaluated traditionally used and emerging risk markers to identify individuals with high-risk of developing CVD in middle-aged men and women with type 2 diabetes. One study was conducted to compare the equivalence between two different ultrasound techniques to measure intima-media thickness since IMT was used to evaluate subclinical atherosclerosis as a surrogate endpoint.. Methods: Data from the cohort study, cardiovascular risk in type 2 diabetes - a prospective study in primary care (CARDIPP) was used in paper I, III and IV. In paper I, baseline data from the first 247 subjects was analysed. Associations between traditionally measured lipids, apolipoproteins, glycaemic control and low-grade inflammation and IMT were analysed.. In paper III, the full baseline cohort, with data from 761 subjects from the CARDIPP study was ...
We have used carotid IMT rather than CHD as our outcome. Carotid IMT has been shown to be strongly associated with prevalent and incident CHD.13,18 It has been suggested that the difference in IMT between women and men may be explained by differences in luminal diameter.22 However, this has been shown not to be the case in the large Tromso study.14 There was a differential in the response between women and men in our study and a difference in the nature of the sampling frame for women and men. Men were survivors of a prospective cohort, whereas women were a newly selected random sample. While among the men responders did not appear to differ from non-responders with respect to age, women who responded were younger than those who did not and women were on average slightly younger than men in the final study sample. All results presented in this study are adjusted for age. Mean blood pressure, lipid levels, and waist-hip ratios for both women and men from this study are similar to those for ...
Results A total of 76 patients were screened and 22 RA patients who were in low disease activity or remission were included. Patients with RA had significantly higher median cIMT, 0.53 (IQR0.13) mm compared to controls, 0.47 (IQR 0.14) mm, p=0.01. In RA patients, the cIMT had significant positive correlation with age (rs=0.84, p=0.00), systolic BP (rs=0.45, p=0.04), waist circumference (rs=0.43, p=0.04), total cholesterol (rs=0.54, p=0.01), BMI (rs=0.45, p=0.04) and serum IL-17 (rs=0.45, p=0.03) but negative correlation with total HDL (rs=-0.43, p=0.05). ...
Methods. The study population included 58 patients undergoing percutaneous coronary intervention (PCI) with stenting and at least 10 months of follow-up. All patients underwent ultrasound detection of brachial artery reactivity 30 days after PCI. Flow mediated dilatation (FMD) was investigated after 5 minutes of occlusion of the artery and nitroglycerin mediated dilation (NMD) was investigated after administration of sublingual nitrates. Vascular echography was performed to measure intima media thickness (IMT) of carotid arteries. At baseline we evaluated all the established traditional cardiovascular risk factors. We also subdivided our study cohort according to values of FMD in patients with FMD above and patients below the median value ...
Bronner Handwerger, ND. Assessing cardiovascular risk factors is always part of the naturopathic intake. The question arises as to how we assess these risks. We recognize that traditional markers like cholesterol, HDL, LDL, Lp(a), fibrinogen, homocysteine and even cardio CRP provide us with valuable information, along with family history. Although these are important to assess, they still do not give us the kind of reliable information we are looking for.. Cardiovascular disease is the No. 1 killer in the U.S. for both men and women. Heart disease and stroke account for almost six million hospitalizations each year, and more than 40% of all people age 45 and older have some form of cardiovascular disease. Approximately 1.1 million Americans are expected to have a new or recurrent heart attack this year, and 60% of all deaths in the U.S. are attributed to cardiovascular disease. A more sobering statistic is that 40%-50% of all heart attack patients have a "normal" cholesterol or lipid profile, ...
Results The groups were similar in age and gender. The biomass fuel group had greater unadjusted mean CIMT (0.66 vs 0.60 mm; p,0.001), carotid plaque prevalence (26% vs 14%; p=0.03), systolic blood pressure (118 vs 111 mm Hg; p,0.001) and median household PM2.5 (280 vs 14 µg/m3; p,0.001). In multivariable regression, the biomass fuel group had greater mean CIMT (mean difference=0.03 mm, 95% CI 0.01 to 0.06; p=0.02), a higher prevalence of carotid plaques (OR=2.6, 95% CI 1.1 to 6.0; p=0.03) and higher systolic blood pressure (mean difference=9.2 mm Hg, 95% CI 5.4 to 13.0; p,0.001).. ...
Methods: 48-wk prospective cohort study to compare changes in IMT and inflammation markers in ART-naïve HIV+ adults and age, sex and race-matched healthy controls. Diabetes and cardiovascular disease (CVD) were exclusionary. ANCOVA was used to adjust means. Correlation coefficients and multivariable linear regression were used to explore relationships between baseline and change in IMT and inflammation markers ...
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OBJECTIVE: Increased arterial stiffness and carotid intima-media thickness (IMT) are considered independent predictors of cardiovascular events. The aim of this study was to compare a system recently developed in our laboratory for automatic assessment of these parameters from ultrasound image sequences to a reference radio frequency (RF) echo-tracking system. METHODS: Common carotid artery scans of 21 patients with cardiovascular risk factors and 12 healthy volunteers were analyzed by both devices for the assessment of diameter (D), IMT, and distension (DeltaD). In the healthy volunteers, analyses were repeated twice to evaluate intraobserver variability. Agreement was evaluated by Bland-Altman analysis, whereas reproducibility was expressed as a coefficient of variation (CV). RESULTS: Regarding the agreement between the two systems, bias values +/- SD were 0.060 +/- 0.110 mm for D, -0.006 +/- 0.039 mm for IMT, and -0.016 +/- 0.039 mm for DeltaD. Intraobserver CVs were 2% +/- 2% for D, 5% +/- ...
At baseline, 783 patients were recruited for the evaluation. During the follow-up period (5.46 ± 0.39 years), 50 coronary events and 35 strokes were recorded. These patients were older and had higher systolic and diastolic BP, higher baPWV, higher IMT, and higher FRS, compared with those without such events. CVD occurred more frequently in men than in women.. The Kaplan-Meier curves showed lower event-free rates with higher IMT (using the fourth quintile of IMT as the cutoff value; log-rank χ2 = 8.87; P = 0.03), baPWV (using the fourth quintile of baPWV as the cutoff value; log-rank χ2 = 9.83; P = 0.02), and Framingham score (FRS ≤10%, FRS ,10% but ≤20%, FRS ,20%; log-rank χ2 = 23.1; P , 0.001).. Next, we examined the ability to predict CVD at ∼5 years by evaluating ROC. The areas under the ROC curves for IMT and baPWV were similar (0.590 and 0.583, respectively), although that for FRS was modestly higher (0.645). Simple addition of both IMT and baPWV to FRS results in only a modest ...
Results: The level of glycosylated hemoglobin and CIMT progressively increased across quintiles of IGP (P for trend = 0.01 for both). In univariate analysis, all examined glycemic parameters were significantly correlated with CIMT. IGP (r = 0.40; P = 0.006) showed the strongest correlation with CIMT, which remained significant in multiple linear regression analysis (R-2 = 0.26; P = 0.01). IGP was associated with a significant increase of CIMT in tertiles of glycosylated hemoglobin. IGP occurred within 1 h from the start of the meal in 95% of the entire diabetic population ...
Results For CIMT≥1.38 mm (≥3rd quartile), the sensitivity and specificity of ≥3-territory involvement were 90.0% and 82.6%. MA≥6.85 mg/dl (≥3rd quartile), the sensitivity and specificity of ≥2-territory involvement were 54.9% and 83.3%. CV events occurred in 104 subjects. The Kaplan-Meier 2-year CV event-free survival was 93.9% and 95.7%; 95.7% and 89.6%; 73.9% and 72.3%; 59.6% and 66% in patients with mean-CIMT and MA values in the 1st; 2nd; 3rd and 4th quartile. The multivariable Cox proportional hazard model identified: mean-CIMT ≥1.38 mm (RR=1.83; CI 1.049 to 3.196; p,0.001), MA≥6.84 mg/dl (RR=0.99; CI 0.576 to 1.703; p,0.001). Inclusion of CIMT into the stratification model significantly improved the prediction of CV event risk (Δχ2=7.098, p,0.001) whereas the impact of the MA is not significant (△χ2=0.002, p,0.001).. ...
Numerous studies over the past 2 decades have demonstrated the benefit of low-density lipoprotein (LDL) cholesterol lowering on heart attack, stroke, and cardiac death (1). Both invasive and noninvasive imaging approaches have been used as surrogate markers to demonstrate benefits of LDL lowering on atherosclerosis. Studies using intravascular ultrasonography (IVUS) of the coronary arteries have demonstrated that statin initiation is associated with halting of plaque progression, and, in fact, with more potent statins, evidence of plaque regression (2). Carotid intima-media thickness studies with ultrasonography have likewise demonstrated benefit of statin therapy (3). These studies have primarily been conducted over the first year or 2 after initiation of statins, and the endpoint used has been coronary plaque volume or greatest plaque area in the case of IVUS and carotid wall thickness in the case of carotid intima-media thickness. Noninvasive imaging with magnetic resonance imaging (MRI) of ...
In adults, the association between MHO and disease outcomes has repeatedly been examined. Early reports suggested that individuals with MHO were not at increased risk of CVD compared with individuals with metabolically healthy normal weight (4,5). However, several recent prospective cohort studies have found an increased CVD risk associated with MHO (3,27-32). A prospective cohort study in the U.K. consisting of 3.5 million adults with a median follow-up time of 5.4 years showed that MHO was associated with CVD compared with metabolically healthy normal weight (30). The large European Prospective Investigation into Cancer and Nutrition study (EPIC-CVD), which included 520,000 European adults, also found increased risk of coronary heart disease among MHO individuals (32). There are several possible explanations for the controversial early results in adults. First, there is no consensus definition of MHO. The prevalence of MHO was reported to range from 3 to 32% in men and from 11 to 43% in women ...
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International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
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Background: Type 2 diabetes is a common disease with increased mortality and morbidity due to cardiovascular disease (CVD). This thesis is based on three studies that evaluated traditionally used and emerging risk markers to identify individuals with high-risk of developing CVD in middle-aged men and women with type 2 diabetes. One study was conducted to compare the equivalence between two different ultrasound techniques to measure intima-media thickness since IMT was used to evaluate subclinical atherosclerosis as a surrogate endpoint.. Methods: Data from the cohort study, cardiovascular risk in type 2 diabetes - a prospective study in primary care (CARDIPP) was used in paper I, III and IV. In paper I, baseline data from the first 247 subjects was analysed. Associations between traditionally measured lipids, apolipoproteins, glycaemic control and low-grade inflammation and IMT were analysed.. In paper III, the full baseline cohort, with data from 761 subjects from the CARDIPP study was ...
Background: Patients with mild-to-moderate renal failure have an increased risk of cardiovascular disease (CVD), which is not fully explained by the presence of classical cardiovascular risk factors. Oxidative stress has been proposed to play a major role in the development of CVD among renal failure patients. We investigated, in patients with mild-to-moderate chronic kidney disease (CKD), the effect of an oxidative-stress-lowering therapy with pravastatin, vitamin E and homocysteine-lowering on carotid intima-media thickness and endothelial function (two strong surrogate markers of cardiovascular risk), and renal function.. Methods: 93 patients with CKD (Cockcroft-Gault equation; mean: 41±17 ml / min per 1.73 m2) who were free of manifest arterial occlusive disease and diabetes mellitus were included in the Anti-oxidant Therapy In Chronic renal insufficiency (ATIC) study, a randomized, double-blind, placebo-controlled trial. The active treatment group received pravastatin 40 mg/day to which ...
The paper by Dawson et al. (1) in this issue of the Journalasks: what factors predict or drive the early phases of atherosclerosis, in adolescence and early adulthood, as indexed by aortic intima-media thickness (aIMT) and carotid intima-media thickness (cIMT)? It uses data from 635 members of the Muscatine Offspring Study cohort to do so. And it leads to an important conclusion.. Metabolic syndrome factors (MSF) predict elevated aIMT and cIMT in adolescence (age 11 to 17 years) and young adulthood (age 18 to 34 years). Not all potential risk factors were evaluated: so-called emerging risk factors were absent from consideration (2). In fact, MSF constituted many of the variables assessed (age, sex, and smoking were also measured; among adolescents, smoking was rare and low volume).. With this proviso, in adolescents, adjusting for age, sex, and height, aIMT was linked to triglycerides, systolic and diastolic blood pressure (BP), body mass index (BMI), and waist/hip ratio (WHR); cIMT was linked ...
We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT ...
The Common carotid intima media thickness (CCIMT), an established indicator of atherosclerosis and an important functional predictor of cardiovascular system3,9 can effectively be used to measure progress of atherosclerosis and also to assess the success of interventions 2,8.. What is known is that measurement of CCIMT by non-invasive B-mode ultrasonography can detect atherosclerosis at the earliest preclinical stage and help in the prediction and diagnosis of asymptomatic vascular disease.3,14,15. Our study demonstrates the factors which have the strongest correlation with CCIMT and hence with pan-atherosclerosis.. In the present study, comparison of the cases (Group I) with the age- and sex-matched controls (Group II), revealed a higher duration of diabetes, hypertension and dyslipidaemia in the latter Group 2. These patients also had a significantly higher mean CCIMT value. With these points in mind let us consider the correlation of risk factors with CCIMT in our patients. In our analysis, ...
The Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6: HDL and LDL Treatment Strategies in Atherosclerosis (ARBITER 6-HALTS) study was a randomized controlled trial comparing the effect of a statin combined with either ezetimibe (Zetia®) or niacin ER 2000 mg daily on carotid intima media thickness (CIMT) measured by ultrasonography. Patients enrolled in this study had established coronary heart disease (CHD) or CHD risk equivalent, had been taking a stable dose of a statin and had an LDL-C < 100 mg/dL (mean ~ 84 mg/dL overall) and HDL < 50 mg/dL for males and < 55 mg/dL for females (mean ~ 44 mg/dL overall) at baseline. At 14 months the statin combined with ezetimibe reduced LDL-C (-17.6 ± 20.1 mg/dL) and HDL (-2.8 ± 5.7mg/dL); niacin also reduced LDL-C (-10 ± 24.5 mg/dL) but increased HDL (7.5 ± 9.2 mg/dL). The trial was halted early with only 208 of 363 randomized patients completing the study due to achievement of a statistically significant ...
Spirometry Ultrasonography Electro Cardiology (Ekg) Echocardiogram Holter Monitor Carotid Intima Media Thickness (CIMT) A scan that is one of the most accurate
Background: Large aortic arch plaques are associated with ischemic stroke. Carotid intima-media thickness (CIMT) is a marker of subclinical atherosclerosis and a strong predictor of cardiovascular disease and stroke. The association between CIMT and aortic arch plaques has been studied in patients with strokes, but not in the general population. The aim of this study was to investigate this association in an elderly asymptomatic cohort and to assess the possibility of using CIMT to predict the presence or absence of large aortic arch plaques. ...
OBJECTIVE: We investigated the potential relationship between T-cell phenotype, inflammation, endotoxemia, and atherosclerosis evaluated by carotid intima-media thickness (IMT) in a cohort of HIV-positive patients undergoing long-term virologically suppressive combination antiretroviral therapy (cART). DESIGN: We studied 163 patients receiving virologically suppressive cART. METHODS: We measured IMT (carotid ultrasound); CD4+/CD8+ T-cell activation (CD38, CD45R0), differentiation (CD127), apoptosis (CD95), and senescence (CD28, CD57) (flow cytometry); plasma sCD14, IL-6, TNF- α, sVCAM-1, hs-CRP, anti-CMV IgG (ELISA); LPS (LAL). The results were compared by Mann-Whitney, Kruskal-Wallis or Chi-square tests, and factors associated with IMT were evaluated by multivariable logistic regression. RESULTS: Of 163 patients, 112 demonstrated normal IMT (nIMT), whereas 51 (31.3%) had pathological IMT (pIMT: ≥1 mm). Of the patients with pIMT, 22 demonstrated an increased IMT (iIMT), and 29 were shown to ...
A carotid intima-media thickness scan measures the thickness of the carotid arteries inner walls. Ultrasound imaging of the carotid arteries can also reveal
Methods. As a quantitative index of atherosclerosis, we measured the carotid intima-media thickness (IMT) in 68 patients with SLE and related the atherosclerosis to a detailed lipoprotein profile generated using nuclear magnetic resonance (NMR). We measured the cholesterol transported by the pool of remnant lipoproteins (RLPc) and evaluated the modulatory effect of the APOE genotype on the lipoprotein subclass profile and atherosclerosis associated with SLE. ...
Risk, Disease, Atherosclerosis, Treatment, Carotid Intima-media Thickness, Cardiovascular Disease, Mortality, Artery, Prevalence, Hospital, Survival, Risk Factors, Death, Patients, Time, Literature, Population, Regression, Screening, Sex
In the meantime, for the many doctors who read this blog, Ive solicited the opinion of a friend and internationally-recognized lipidologist, Tom Dayspring, MD. Heres his response to the newest study data. Its a long, and complex read, but well worth it for medical professionals:. By now you have likely heard something about the ARBITER-6 HALTS trial which was just presented at the AHA and published in the New England Journal of Medicine. Basically this is a trial designed to show what happens to carotid intima-media thickness (IMT) when either Zetia or Niaspan is added to a long term statin use.. For those who do not know, I am a consultant and National Speaker for both Abbott Labs and Merck (Schering Plough). I educate professionals all the time about aggressive use of lipid drugs to achieve goals.. I believe Niaspan, Zetia, fenofibrate, Trilipix, and Lovaza are grossly under prescribed. They are all potential "statin-helper" drugs.. Without outcome data (data on heart attacks, strokes, ...
Finnish researchers investigated the relationship between blood serum levels of lycopene and intima-media thickness (IMT) in 1028 middle-aged men (aged 46-64 years).
Hand-held ultrasonic thickness gages are an accurate, repeatable tool for nondestructively measuring wall thickness from one side of a part in both manufacturin
TY - JOUR. T1 - Association of pathobiologic determinants of atherosclerosis in youth risk score and carotid artery intima-media thickness in asymptomatic young heterozygous familial hypercholesterolemia patients. AU - Cheng, Hao Ming. AU - Ye, Zhong Xuan. AU - Charng, Min Ji. PY - 2011/9. Y1 - 2011/9. N2 - Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by extremely high cholesterol level, accelerated atherosclerosis and premature cardiovascular disease.We need an early risk stratification method for this population. Arisk score formula to estimate the probability of advanced atherosclerosis using coronary heart disease risk factors was developed for persons 15-34 years of age by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. This studys aim was to investigate the relation between PDAY risk score and carotid intima-media thickness (IMT) and inflammation markers in asymptomatic young FH subjects. Methods: We included 23 ...
We have reported that psoriatic arthritis (PsA) patients without overt cardiovascular diseases have evidence of premature atherosclerosis as indicated by an increased carotid intima-media thickness (IMT).1 Whether an increase in IMT reflects current (but reversible) inflammation of the vessel wall rather than more permanent structural vessel changes in PsA has never been assessed. We undertook a prospective, observational study to determine whether a 12-week treatment of tumour necrosis factor alpha (TNFα) blockers may reduce IMT in patients with active PsA, and whether the changes in IMT can be sustained in patients who were continued on long-term TNFα blockers.. Twenty consecutive PsA patients with active disease were recruited to receive TNFα blockers. After 12 weeks, nine patients continued (group 1) while 11 patients discontinued TNFα blockers due to financial constraints (group 2). Twenty PsA patients who were naive to TNFα blockers were recruited as controls (group 3). Patients … ...
In the present analysis, we observed no additional value of measurement of mean common CIMT in risk classification among 17 254 individuals free from symptomatic CVD, but with elevated blood pressure levels. For those at intermediate risk, the addition of common CIMT to an existing cardiovascular risk score is small but statistically significant. However, the decision on whether or not to implement common CIMT measurements in individuals with elevated blood pressure levels at intermediate risk depends on the balance between costs of additional risk assessment by CIMT measurements and effectiveness in preventing CVD.. In asymptomatic individuals with elevated blood pressure, guidelines recommend cardiovascular risk assessment and suggest screening for subclinical vascular damage.1,5-7 It has been suggested that providing a more accurate assessment of vascular damage related to hypertension may lead to a more precise stratification of CVD risk.20 As such, the 2007 ESH/ESC hypertension guidelines ...
Background:B-mode ultrasound measurements of the echolucency of the carotid intima-media may hold information on cardiovascular risk. The information obtained from this measurement may depend on which gain settings are used. We studied the effect of gain settings on echolucency measurements and its consequences on risk factor relations and treatment effects.Methods:We used two approaches. In the first, we examined the relationship between calibration, gain and common grey-scale median (GSM) from repeated ultrasound images obtained from four healthy individuals at gain settings ranging from -20 to 20dB. In the second, we evaluated the effect of gain settings on the relation of risk factors and statin treatment with common GSM, using images from 325 participants of the Measuring Effects on Intima-Media Thickness: an Evaluation of Rosuvastatin (METEOR) study with documented gain settings. Echolucency of the carotid intima-media was measured from ultrasound images using PaintShop Pro and Artery ...
We have shown that even after adjusting for multiple confounding factors, a tertiary care cohort of psoriasis patients have a 2.67-fold higher odds of having atherosclerosis compared to controls. The most striking finding was that after age stratification, almost half (49 %) of patients with psoriasis aged 30-39 years had evidence of subclinical atherosclerosis as compared to 15 % of controls. These findings are suggestive that psoriasis may contribute to the inflammatory cascade of atherosclerosis and that the younger a patient develops psoriasis, the higher the CVD risk. These findings are consistent with recent observations from preclinical models systems, wherein chronic skin-contained inflammation, but not acute, promoted the acceleration of arterial thrombosis [19] and [20]. In addition, other investigators have also reported observational studies demonstrating relatively higher measures of association with CV events in younger individuals [25, 42-44]. Psoriasis sufferers with ...
After controlling for age and sex, we report not only that CHD risk factors but also that CCA and ICA IMTs are elevated in individuals before the onset of clinical diabetes. Moreover, increased CCA IMT predicted diabetes. Hence, in our study population, we have established that early atherogenesis, not merely elevated cardiovascular risk factors, is present before the development of clinical diabetes, and thus, enhanced atherogenesis is not solely dependent on the clinical manifestation of diabetes.. Jarrett,15 Jarrett and Shiply,16 and later Stern17,18 hypothesized not only that diabetes and cardiovascular disease are related as cause and effect but also that both conditions originate from a "common soil." This hypothesis suggests an atherogenic state before the onset of clinical diabetes, which is consistent with the regularly reported finding that CHD risk factors are elevated in prediabetic individuals1-5 and the recently reported finding in the Nurses Health Study (NHS) of elevated ...
Evidences indicate that skeleton works not only as a structural scaffold but also as an endocrine organ. Many bioactive factors secreted from bone, such as osteocalcin and osteoprotegerin, have a regulatory role in energy metabolism [21, 22]. Recent studies have suggested a potentially important role for osteocalcin in regulating the function of vascular endothelial cells, and the cardiovascular system [23, 24]. This suggests osteocalcin could be involved in the development of CAD. Several studies have investigated the association between osteocalcin and atherosclerosis, but results have not been consistent. Some studies suggest osteocalcin may actually be protective against early atherosclerosis. For example, a study from Korea demonstrated an independent effect of osteocalcin on vascular endothelial cells, suggesting that osteocalcin could have beneficial effects on atherosclerosis [25]. Our previous study in high fat diet animals indicate that osteocalcin has an endothelial-protective effect ...
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular risk. We hypothesized that the number of cardiovascular risk factors determines the progression of vascular aging. One hundred forty-two subjects (mean age 51.9 years, 94 men) without established cardiovascular disease were investigated in 2 examinations over a 2-year period. Subjects were classified at baseline according to their number of risk factors (from 0 to 2 and more). Subjects had determinations of carotid-femoral pulse wave velocity, aortic augmentation index, brachial flow-mediated dilatation, and common carotid intima-media thickness and their annual absolute changes were calculated. Subjects with more risk factors had a gradual higher annual progression of pulse wave velocity (0.092 m/s/y for 0, 0.152 m/s/y for 1, and 0.352 m/s/y for 2 and more; P=0.007). Patients with both hypertension and dyslipidemia have 4× higher annual progression rate compared with ...
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality and disability in most countries (1). Approximately 30% of first acute events are fatal, and survivors often experience sequelae and a shortened life expectancy (2,3). Primary prevention is thus the best approach to fighting this pandemic disease. Current algorithms for risk detection, which combine behavioral, clinical, and biochemical markers, are of limited accuracy, and better risk stratification methods are definitely needed (4,5).. Used in combination with traditional risk factors, data on subclinical atherosclerosis can provide additional information about the risk of myocardial infarction, stroke, and cardiovascular disease (CVD) mortality (6-8). Carotid wall intima-media thickness estimated from ultrasonographic images has been proposed as a surrogate measure of subclinical atherosclerosis (9). Whereas some prospective studies have shown that intima-media thickness adds predictive capacity to traditional ...
Afaq F, Saleen M, et al. Anthocyanin- and Hydrolyzable Tannin-Rich Pomegranate Fruit Extract Modulates MAPK and NF-kappaB Pathways and Inhibits Skin Tumorigenesis in CD-1 Mice. Int. J. Cancer 2005; 113(3): 423-433.. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004; 23(3): 423-33.. Rasheed Z, Akhtar N, et al. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. Journal of Inflammation 2009; 6(1). ...
Afaq F, Saleen M, et al. Anthocyanin- and Hydrolyzable Tannin-Rich Pomegranate Fruit Extract Modulates MAPK and NF-kappaB Pathways and Inhibits Skin Tumorigenesis in CD-1 Mice. Int. J. Cancer 2005; 113(3): 423-433.. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004; 23(3): 423-33.. Rasheed Z, Akhtar N, et al. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. Journal of Inflammation 2009; 6(1). ...
Ultrasound study to assess Carotid Intima Media Thickness in an office setting 525 patients to be enrolled at seven medical centers DALLAS - November 13, 2005 - SonoSite, Inc. (NASDAQ: SONO), the world leader in hand-carried ultrasound, announced today at the 2005 American Heart Association (AHA) Scientific Sessions that it is initiating a multi-center study to determine whether the addition of an ultrasound examination evaluating carotid artery wall thickness (CIMT), performed in the office setting, will provide a more effective tool for risk assessment and prevention of cardiovascular disease than current clinical methods alone. Over 20 years of clinical research has shown that the thickness (T) of the two innermost layers of the carotid artery wall, the intima (I) and media (M), begins to increase before plaque is evident within the vessel. This increased wall thickness is associated with an increased risk of cardiovascular disease, the leading cause of mortality and disability in the United States
Background- Genome-wide association studies have recently identified a locus on chromosome 9p21 that influences risk of coronary artery disease (CAD). The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD). Methods and Results- We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD. Both mean and maximum CIMT were significantly higher (P,0.001) in the older subjects of the Health 2000 Survey compared with the Young Finns Study. However, there was no association of the rs1333049 genotype with either mean or maximum CIMT at either age (P=0.959 and 0.977 for the 2 phenotypes in the Young Finns Study and P=0.714 and 0.725 in the ...
Childhood obesity is associated with an increased carotid intima-media thickness (IMT) and stiffness. Increased carotid wall thickening and rigidity are considered markers of subclinical atheroscleros
A Syngle1, I Verma2, N Garg2, P Krishan2. 1Cardio Rheuma, Healing Touch City Clinic and Fortis Hospital, Chandigarh, India,. 2Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Objectives: Ankylosing spondylitis (AS) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that depleted endothelial progenitor cells (EPCs), mediators of inflammation and carotid intima media thickness (cIMT) are associated with atherosclerosis in other populations and would be increased and associated with the severity of coronary atherosclerosis in patients with AS. Methods: We compared 30 patients of AS with 22 healthy controls. CD34+, CD133+, were used to quantify EPCs using flow cytometry. Flow-mediated dilatation (FMD) was assessed by using AngioDefenderTM (Everist Health, Ann Arbor, MI, United States). CIMT was measured using ultrasonography. Pro-inflammatory cytokines and inflammatory disease activity measures, Bath Ankylosing Spondylitis ...
A Syngle1, I Verma2, N Garg2, P Krishan2. 1Cardio Rheuma, Healing Touch City Clinic and Fortis Hospital, Chandigarh, India,. 2Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Objectives: Ankylosing spondylitis (AS) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that depleted endothelial progenitor cells (EPCs), mediators of inflammation and carotid intima media thickness (cIMT) are associated with atherosclerosis in other populations and would be increased and associated with the severity of coronary atherosclerosis in patients with AS. Methods: We compared 30 patients of AS with 22 healthy controls. CD34+, CD133+, were used to quantify EPCs using flow cytometry. Flow-mediated dilatation (FMD) was assessed by using AngioDefenderTM (Everist Health, Ann Arbor, MI, United States). CIMT was measured using ultrasonography. Pro-inflammatory cytokines and inflammatory disease activity measures, Bath Ankylosing Spondylitis ...
A Syngle1, I Verma2, N Garg2, P Krishan2. 1Cardio Rheuma, Healing Touch City Clinic and Fortis Hospital, Chandigarh, India,. 2Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Objectives: Ankylosing spondylitis (AS) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that depleted endothelial progenitor cells (EPCs), mediators of inflammation and carotid intima media thickness (cIMT) are associated with atherosclerosis in other populations and would be increased and associated with the severity of coronary atherosclerosis in patients with AS. Methods: We compared 30 patients of AS with 22 healthy controls. CD34+, CD133+, were used to quantify EPCs using flow cytometry. Flow-mediated dilatation (FMD) was assessed by using AngioDefenderTM (Everist Health, Ann Arbor, MI, United States). CIMT was measured using ultrasonography. Pro-inflammatory cytokines and inflammatory disease activity measures, Bath Ankylosing Spondylitis ...
The primary prevention of cardiovascular disease involves classifying individuals according to their global cardiovascular risk. However, those at intermediate risk represent a particular challenge; while some may require aggressive treatment, others may be best managed by lifestyle measures alone. Biomarkers that have shown promise in improving risk discrimination include carotid intima-media thickness (CIMT), coronary artery calcium (CAC) scoring, brachial flow-mediated dilation (FMD), ankle-brachial index (ABI), high-sensitivity C-reactive protein (CRP) and, in addition, having a family history of coronary heart disease (CHD). Determining whether - and by how much - risk prediction can be improved by various markers could help to determine the most efficient strategy for the use of primary prevention drugs.. 1330 intermediate risk participants (Framingham risk score of ,5% and ,20% for a coronary event within the next ten years) in the Multi-Ethnic Study of Atherosclerosis (MESA) were ...
Conclusions Cumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima-media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may...
Garovic VD, Milic NM, Weissgerber TL, Mielke MM, Bailey KR, Lahr B, Jayachandran M, White WM, Hodis HN, Miller VM. Carotid Artery Intima-Media Thickness and Subclinical Atherosclerosis in Women With Remote Histories of Preeclampsia: Results From a Rochester Epidemiology Project-Based Study and Meta-analysis. Mayo Clin Proc. 2017 Sep; 92 (9):1328-1340 Epub 2017 Aug 25 ...
TY - JOUR. T1 - The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. AU - Wijnands, J.M.A.. AU - Boonen, A.. AU - Dagnelie, P.C.. AU - van Greevenbroek, M.M.J.. AU - van der Kallen, C.J.H.. AU - Ferreira, I.. AU - Schalkwijk, C.G.. AU - Feskens, E.J.M.. AU - Stehouwer, C.D.A.. AU - van der Linden, S.. AU - Arts, I.C.W.. N1 - WOS:000344644800024. PY - 2014. Y1 - 2014. N2 - Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased ...
Significant evidence has accumulated that psychosocial stress contributes to the etiology and pathogenesis of coronary artery disease. In addition to direct influences through the nervous, endocrine, and immune systems, stress reduces the adoption and maintenance of a healthy lifestyle and adherence to medical care (1). Epidemiological evidence is compelling; several large and international studies have shown that individuals reporting high levels of psychosocial stress have significantly elevated risk of cardiovascular diseases. Most notably, the INTERHEART study demonstrated that among more than 30,000 individuals, those who reported elevated stress had odds ratios for myocardial infarction of 2.5 (2). High work demands and daily stress have also been associated with coronary heart disease (CHD) morbidity and mortality, with carotid artery intima-media thickness progression, and with recurrent events. The most recent addition to this literature was the finding in the prospective Womens Health ...
Therapy-resistant hypertension was present in 9.1% of hypertensive patients with clinically manifest vascular disease and 49.5% had uncontrolled but non-resistant hypertension. Clinical characteristics related to aTRH were higher age, female sex, BMI and waist circumference, diabetes mellitus and duration and multiple locations of vascular disease, lower eGFR and albuminuria. Patients with aTRH had greater carotid intima-media thickness and lower ABI representing greater burden of subclinical vascular damage.. The prevalence of aTRH has been reported to be 9%-13% in the general hypertensive population.20-22 In patients with chronic kidney disease (CKD), known for their high cardiovascular risk, a much higher prevalence of 25%-35% has been found, often using a more stringent BP definition of ,130/80 mm Hg.23-25 Although several reports have shown a higher prevalence of vascular disease in those with aTRH in hypertensive populations,21 22 26-28 the exact aTRH prevalence in patients with clinical ...
The results of this study suggest that HI statin therapy provides a mortality benefit over LMI statin therapy in patients with PAD. This effect was accompanied by a significant reduction in MACE and is consistent with the results of several large randomized controlled trials demonstrating reduced mortality and secondary ischemic events in patients with atherosclerosis of the coronary and cerebral vasculature treated with HI statin therapy.13, 14, 15, 18. The benefit of lowering LDL in preventing MACE has been well described, particularly among patients with coronary atherosclerosis. HI statins exert potent LDL‐lowering effects and may mediate additional benefits through pleiotropic mechanisms leading to atherosclerotic regression and plaque stabilization.19, 20 Indeed, mechanistic studies have demonstrated that HI statin therapy (atorvastatin 80 mg daily) is associated with greater regression of carotid intima-media thickness and coronary atherosclerosis compared with moderate‐intensity ...
The researchers selected 24 men with severe OSA and no other comorbidities and randomly assigned them to receive either CPAP therapy or no treatment. After establishing the baseline data for each subject, they then tracked several indicators of pre-clinical atherosclerosis, including carotid intima-media thickness (a measure of arterial plaque), pulse-wave velocity (a measure of arterial stiffness), carotid diameter, C-reactive protein (a marker of inflammation), and catecholamine level (a marker of physical stress) over the course of four months ...
Results. Forty-two patients were followed for 7.1 ± 2.6 years. Eight patients (18.9%) had MCVE. The respective 5- and 10-year MCVE rates were 9.5% and 26.8%. National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III)-defined high-risk status [hazard ratio (HR) 5.02 (95% CI: 1.17-27.4), p = 0.03], BMI , 30 kg/m2 [HR 4.84 (95% CI: 1.46-116), p = 0.02], and plaque detection in the abdominal aorta (p = 0.01) were significantly associated with MCVE. SNV characteristics, corticosteroid maintenance therapy, and C-reactive protein , 5 mg/l were not associated with MCVE. Plaque in the aorta was significantly associated with high-risk status (p , 0.001), while BMI and high-risk status were independent variables. Thus, a BMI , 30 kg/m2 and/or a high-risk status were strongly associated with MCVE (p = 0.004). Carotid intima-media thickness (IMT) identified patients with early MCVE and was correlated with the time to MCVE (r2 = 0.68, p = 0.01). ...
Servicios Quirurgicos del Caribe offers a variety of exams and tests to study and evaluate vascular health and to measure the extent of possible vascular disease. We offer various Doppler exams, abdominal vascular study, venous mapping, and carotid intima-media thickness tests to provide our patients with a thorough diagnosis of their vascular health. Are you interested in learning more about the vascular studies conducted by Dr. Trina Steljes? Contact our office in Mayaguez today for more information or to schedule a consultation with a member of our staff! ...
Sigma-Aldrich offers abstracts and full-text articles by [Kenji Okumura, Hideto Tsukamoto, Hideyuki Tsuboi, Haruo Hirayama, Haruo Kamiya, Masato Watarai, Ryoji Ishiki, Toyoaki Murohara].
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). http://www.escardio.org/guidelines-surveys/esc-guidelines/Pages/cvd-prevention.aspx The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Perk J., De Backer G., Gohlke H., Graham I., Reiner Z., Verschuren M., Albus C, Benlian P, Boysen G, Cifkova R, Deaton C, Ebrahim S, Fisher M, Germano G, Hobbs R, Hoes A, Karadeniz S, Mezzani A, Prescott E, Ryden L, Scherer M, Syvänne M, Scholte op Reimer WJ, Vrints C, Wood D, Zamorano JL, Zannad F. European Heart Journal (2012) 33, 1635- ...
Assessment of subclinical atherosclerosis and cardiovascular risk.: Conventional cardiac risk factors do not fully explain the incidence of coronary artery dise
OZCETIN, Mustafa et al. The importance of carotid artery stiffness and increased intima-media thickness in obese children. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.5, pp.295-299. ISSN 2078-5135.. BACKGROUND: Atherosclerosis that starts in childhood invariably advances during adulthood. AIM: We aimed to study the effect of obesity on main carotid artery intima-media thickness (CIMT) and arterial stiffness. MATERIAL AND METHODS: A total of 78 children were studied from October 2010 to February 2011. They were divided into obese (n=42, group 1) and normal (n=36, group 2). All children were subjected to physical examination, routine biochemical and haematological analysis, carotid ultrasonography and echocardiographic measurements. A detailed medical history was obtained. Body mass index (BMI) was calculated by dividing participants weight in kilograms by the square of their height in metres. Stiffness index β was calculated using blood pressure and diameter of the systolic and diastolic ...
Aim: To investigate risk factors which impact on common carotid artery intima media thickness (IMT). Methods: A total of 86 obese children and adolescents and 22 healthy children and ...
The Carotid Atherosclerosis Italian Ultrasound study (CAIUS), a multicenter, double-blind clinical trial, performed in 305 asymptomatic, moderately hypercholesterolemic patients, clearly demonstrated beneficial effects of pravastatin on the carotid intima-media thickness (IMT) progression. The database of the CAIUS study was examined in order to investigate the presence of a relationship, if any, between the activity of pravastatin on IMT progression rate and its hypocholesterolemic effect. Quantitative B-mode ultrasound imaging was used to quantify the individual mean maximum IMT progression rate in 3 years. In the overall group of patients (placebo and pravastatin) covariance analysis showed that while the variable treatment (0 = placebo, 1 = pravastatin) was significantly related to the reduction of IMT progression (F= 6.6, P = 0.01), the IMT progression did not correlate with the extent of LDL-C lowering (F= 0.00, P = 0.98). To further investigate this issue. the pravastatin treated group ...
Childhood obesity is a major health problem throughout the world. Obese children are more likely to become obese adults in whom one can expect a higher rate of hospitalisation, interventions and premature death.1 In obese people, coronary heart disease generally manifests in middle age or later life. However, atherosclerosis has its roots in childhood, its first signs in obese children appearing before puberty; therefore, it is important to develop efficient strategies to reduce the incidence of cardiovascular disease (CVD) in the population. Carotid artery intima-media thickness (CIMT) serves as a marker of preclinical atherosclerosis.2. CVD develops as a result of arterial damage in the form of arteriosclerosis. Arteriosclerosis is a general term for conditions in which diffuse thickening and stiffening in mainly large- and medium-sized arteries develop under different conditions. Both the media and intima of the arteries could be involved in the pathology. Risk factors diagnosed in childhood ...
Background Psoriasis has been associated with vitamin D insufficiency and cardiovascular risk factors. Reports show that serum 25-hydroxyvitamin D (25-OHD) levels are inversely associated with chronic...
Dietary supplementation with polyphenolic antioxidants to animals was shown to be associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. We investigated the effects of pomegranate juice (PJ, which contains potent tannins and anthocyanins) consumption by atherosclerotic patients with carotid artery stenosis (CAS) on the progression of carotid lesions and changes in oxidative stress and blood pressure. Ten patients were supplemented with PJ for 1 year and five of them continued for up to 3 years. Blood samples were collected before treatment and during PJ consumption. In the control group that did not consume PJ, common carotid intima-media thickness (IMT) increased by 9% during 1 year, whereas, PJ consumption resulted in a significant IMT reduction, by up to 30%, after 1 year. The patients serum paraoxonase 1 (PON 1) activity was increased by 83%, whereas serum LDL basal oxidative state and LDL susceptibility to copper ...
Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ...
The study, which looked at intermediate-risk participants (FRS _5%-_20%) in the Multi-Ethnic Study of Atherosclerosis (MESA), found that overall CAC, ABI, high-sensitivity CRP, and family history were independently associated with incident CHD in multivariable analyses (HR, 2.60 [95% CI, 1.94-3.50]; HR, 0.79 [95% CI, 0.66-0.95]; HR, 1.28 [95% CI, 1.00-1.64]; and HR, 2.18 [95% CI, 1.38-3.42], respectively). CAC had the highest improvement in both the area under the receiver operator characteristic curves and net reclassification improvement when added to the Framingham Risk Score/Reynolds score, while brachial flow-mediated dilation had the least. "Carotid intima-media thickness and brachial flow-mediated dilation were not associated with incident CHD in multivariable analyses," according to the authors. ...
Background Little is known about the relative contribution of long-term glycemic variability to the risk of macrovascular complications in type 2 diabetes. This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness (IMT) in type 2 ...
misc{6255e459-8fcc-46d0-a460-4291149361a2, abstract = {Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.,br, Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.,br, Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 ...
Hanna DB, Jung M, Xue X, Anastos K, Cocohoba JM, Cohen MH, Golub ET, Hessol NA, Levine AM, Wilson TE, Young MA, Kaplan RC (2016). Trends in non-lipid cardiovascular disease risk factor management in the Womens Interagency HIV Study and association with adherence to antiretroviral therapy. AIDS Patient Care STDs 30: 445-454.. Hanna DB, Ramaswamy C, Kaplan RC, Kizer JR, Anastos K, Daskalakis D, Zimmerman R, Braunstein SL (2016). Trends in cardiovascular disease mortality among persons with HIV in New York City, 2001-2012. Clin Infect Dis 63: 1122-1129. Hanna DB, Guo M, Bů ková P, Miller TL, Post WS, Stein JH, Currier JS, Kronmal RA, Freiberg MS, Bennett SN, Shikuma CM, Anastos K, Li Y, Tracy RP, Hodis HN, Delaney JA, Kaplan RC (2016). HIV infection and carotid artery intima-media thickness: Pooled analyses across five cohorts of the NHLBI HIV-CVD Collaborative. Clin Infect Dis 63: 249-256. Hanna DB, Felsen UR, Ginsberg MS, Zingman BS, Beil RS, Futterman DC, Strickler HD, Anastos K (2016). ...
THURSDAY, Oct. 11, 2018 (HealthDay News) - Common carotid artery (CCA) wall thickness measured using magnetic resonance imaging (MRI) is more consistently associated with incident cardiovascular disease (CVD) outcomes than intima-media thickness measured by ultrasound, according to a study published online Oct. 9 in Radiology.. Yiyi Zhang, Ph.D., from the Johns Hopkins University Bloomberg School of Public Health in Baltimore, and colleagues conducted a prospective study involving 698 participants without a history of clinical cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis. CCA wall thickness was measured with ultrasound and with non-contrast proton density-weighted and intravenous gadolinium-enhanced MRI. The correlations between wall thickness measured with ultrasound and MRI were assessed with CVD outcomes.. The researchers found that per standard deviation increase in intima-media thickness, the adjusted hazard ratios for coronary heart disease, stroke, and CVD were ...
The focus of this journal club will continue to be the presentation of research being conducted by the CVD training grant trainees and faculty collaborating with the URL, as it relates to subclinical cardiovascular disease. This may take the form of pract...
Objective To investigate the efficacy of taking in valsartan hydrochlorothiazide at the different time points on a blood pressure variability( BPV),carotid intima media thickness( CIMT),notric oxide( NO) and endothelin 1( ET-1). Methods Enrolled 80 hypertensive subjects with stage 1 to 2 essential hypertension,who were treated in Hebei general hospital between June 2015 and February 2017. These subjects were randomly assigned to receive valsartan hydrochlorothiazide( 80 mg/12. 5 mg) either on awakening( Ⅰgroup) or at bedtime( Ⅱgroup). All cases received 24 hours ambulatory blood pressure monitoring and CIMT before and after 12 weeks of treatment. NO and ET-1 were monitored before the treatment and12 weeks after the treatment. Results Compared with the baseline level,24 h mean systolic blood pressure( 24 h MSBP),24 h diastolic blood pressure( 24 h MDBP),24 h systolic blood pressure variability( 24 h SBPV),24 h diastolic blood pressure variability( 24 h DBPV),day SBPV,day DBPV,night SBPV,night DBPV
Aims: To investigate the association between intima-media thickness of brachial and common carotid arteries and factors of the coagulation- and fibrinolysis system with diastolic dysfunction in patients with a previous myocardial infarction. Patients and methods: One hundred and five patients, men (72 %) and women (28%) aged between 32-73 years with a history of previous acute myocardial infarction were included. An age-matched control group with no cardiovascular risk factors was used as a comparison. B-mode ultrasound of common carotid and brachial arteries and echocardiography were evaluated in all subjects. Calculated intima-media area (cIMa) of the common carotid and brachial arteries and tissue Doppler imaging (TDI) were examined. Factors of the coagulation- and fibrinolysis system were also measured. Results: Prothrombin fragment 1+2 was significantly higher in patients with previous myocardial infarction compared to the control group ( ...
Purpose: The aim of this study was to evaluate whether poor oral hygiene is associated with carotid and popliteal arterial intima-media thickness, which is one of the predictors of future progression of sub-clinical atherosclerosis, and high sensitivity C-reactive protein (hsCRP) and fibrinogen levels. Methods: A specialised dentist checked the patients and selected 550 patients during periodontal examinations, according to their oral hygiene. The patients had no history of atherosclerotic disease. Carotid and popliteal artery B-mode ultrasonographic examinations and hsCRP and fibrinogen levels were analysed at baseline and after a mean of 6.2 months. The patients were scored on the DMFT index for the number of decayed (D), missing (M), and filled (F) teeth (T). We also used the Silness-Loe plaque index (SLI) to evaluate oral hygiene and dental plaque. The patients were divided into two groups using the DMFT and SLI criteria. Group I had a DMFT index score from 0 to 3 and SLI index score of 0 or 1.
BACKGROUND AND AIMS: Common mechanisms for the development of micro- and macroangiopathic diabetic complications have been suggested. We aimed to cross-sectionally investigate strength and characteristics of the association between carotid atherosclerosis and microangiopathy in type 2 diabetic patients. METHODS AND RESULTS: Common carotid artery intima-media thickness (cIMT), carotid plaque (CP) type and degree of stenosis were evaluated by ultrasound, along with the determination of anthropometric parameters, HbA1c, lipid profile, assessment of diabetic retinopathy and nephropathy, in 662 consecutive patients with type 2 diabetes mellitus (T2DM). Patients were divided according to high/low cIMT, presence/absence of CP and of retinopathy and nephropathy. Patients with CP were older, more prevalently males, past smokers, had longer diabetes duration, significantly lower HDL cholesterol and more prevalent ischemic heart disease (all p,0.05) as compared to those with cIMT , 1 mm. Microangiopathies ...
Theodore Mazzone, M.D., of the University of Illinois at Chicago College of Medicine, and colleagues studied the effects of a potential new approach, using a drug known as pioglitazone, in 462 adults with type 2 diabetes in the Chicago metropolitan area between 2003 and 2006. Study participants had an average age of 60 and included 289 men and 173 women; they were randomly assigned to receive a daily dose of either pioglitazone (15 to 45 milligrams) or of glimepiride (1 to 4 milligrams), another diabetes medication that works through different mechanisms. At the beginning of the study and again 24, 48 and 72 weeks later, ultrasound was used to measure the thickness of the middle layers of the carotid arteries (which are located in the neck and carry blood to the brain). The measurements are called carotid artery intima-media thickness, or CIMT. Using this measurement, other studies have suggested that thicker artery walls, and changes in artery wall thickness over time, are associated with a ...
TY - JOUR. T1 - Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment. T2 - The framingham study. AU - Romero, José R.. AU - Beiser, Alexa. AU - Seshadri, Sudha. AU - Benjamin, Emelia J.. AU - Polak, Joseph F.. AU - Vasan, Ramachandran S.. AU - Au, Rhoda. AU - Decarli, Charles. AU - Wolf, Philip A.. PY - 2009/5/1. Y1 - 2009/5/1. N2 - Background and Purpose-: Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear. Methods-: We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultrasound, brain MRI, and neuropsychological testing. We related common and internal carotid artery intima-media thickness and internal carotid stenosis to large white matter hyperintensity (,1 SD above age-specific mean), total brain ...
TY - JOUR. T1 - Common carotid arterial stiffness and the risk of ischaemic stroke. AU - Tsivgoulis, Georgios. AU - Vemmos, K.. AU - Papamichael, C.. AU - Spengos, K.. AU - Daffertshofer, M.. AU - Cimboneriu, A.. AU - Zis, V.. AU - Lekakis, J.. AU - Zakopoulos, N.. AU - Mavrikakis, M.. PY - 2006/5/1. Y1 - 2006/5/1. N2 - In the present case-control study we aimed to investigate the association of common carotid arterial (CCA) stiffness with ischaemic stroke (IS) and to determine whether this relationship was independent of conventional risk factors including CCA intima-media thickness (CCA-IMT). CCA distensibility, defined as the change of CCA-diameter during the cardiac cycle, and CCA-IMT were evaluated by means of high-resolution B-mode carotid ultrasound examination in consecutive, first-ever IS patients (n = 193) and in age- and sex-matched control subjects (n = 106). The CCA distensibility (inverse of CCA stiffness) was significantly (P = 0.007) lower in IS (0.353 mm, 95% CI: 0.326-0.379) ...

Carotid Intima-Media Thickness TestCarotid Intima-Media Thickness Test

A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque buildup in the arteries supplying blood ... What is a Carotid Intima-Media Thickness Test?. A carotid intima-media thickness test (CIMT), also known as a carotid artery ... Carotid Intima-Media Thickness Test. A carotid intima-media thickness test (CIMT) is used to determine the extent of plaque ... CIMT uses ultrasound imaging to measure the thickness of the two inner layers of the carotid artery-called the intima and media ...
more infohttps://www.radiologyinfo.org/en/info.cfm?pg=carotid-intima

Periodontal Microbiota and Carotid Intima-Media Thickness | CirculationPeriodontal Microbiota and Carotid Intima-Media Thickness | Circulation

The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128: 262-269. ... Periodontal Microbiota and Carotid Intima-Media Thickness. Moïse Desvarieux, Ryan T. Demmer, Tatjana Rundek, Bernadette Boden- ... Periodontal Microbiota and Carotid Intima-Media Thickness. Moïse Desvarieux, Ryan T. Demmer, Tatjana Rundek, Bernadette Boden- ... Periodontal Microbiota and Carotid Intima-Media Thickness. The Oral Infections and Vascular Disease Epidemiology Study (INVEST) ...
more infohttp://circ.ahajournals.org/content/111/5/576

Reproducibility of Sonographic Measurements of Carotid Intima-Media ThicknessReproducibility of Sonographic Measurements of Carotid Intima-Media Thickness

Background: Carotid intima-media thickness (IMT), measured with B-mode ultrasound, is a marker for atherosclerosis and widely ... COMPARATIVE STUDY OF CAROTID INTIMA MEDIA THICKNESS IN ISCHEMIC STROKE SUBTYPES. Mutu, Cosmin; Minea, Nicoleta; Pereanu, Marcel ... BACKGROUND: Although carotid intima-media thickness (IMT) is the most commonly used ultrasonic measurement of atherosclerosis, ... Flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of the carotid artery are two parameters ...
more infohttp://connection.ebscohost.com/c/articles/35383901/reproducibility-sonographic-measurements-carotid-intima-media-thickness

Factors underlying the increase in carotid intima-media thickness in borderline hypertensives.  - PubMed - NCBIFactors underlying the increase in carotid intima-media thickness in borderline hypertensives. - PubMed - NCBI

Intima-media thickness was measured in the right and left common carotid artery, bulb, and internal carotid artery. Mean IMT (m ... Factors underlying the increase in carotid intima-media thickness in borderline hypertensives.. Pauletto P1, Palatini P, Da Ros ... To define the role played by various risk and behavioral factors in the increase of carotid intima-media thickness (IMT) ... an increase in IMT takes place not only in the common carotid artery but also in the bulb and the internal carotid segment. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10323774

Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy | Diabetes CareAssociation of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy | Diabetes Care

Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy. The Chennai Urban Rural ... Ravikumar R, Deepa R, Shanthirani C, Mohan V: Comparison of carotid intima-media thickness, arterial stiffness, and brachial ... Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy ... Association of Carotid Intima-Media Thickness and Arterial Stiffness With Diabetic Retinopathy ...
more infohttp://care.diabetesjournals.org/content/27/8/1962

Vytorin on Carotid Intima-media Thickness and Overall Rigidity - Full Text View - ClinicalTrials.govVytorin on Carotid Intima-media Thickness and Overall Rigidity - Full Text View - ClinicalTrials.gov

Vytorin on Carotid Intima-media Thickness and Overall Rigidity (VYCTOR). The safety and scientific validity of this study is ... Comparison of the effect on the progression of the carotid intima-media interphase thickness (GIM), arterial rigidity according ... to the measurement of the pulse wave speed and direct measurement of the carotid and aortic rigidities and an inflammation ... Vytorin on Carotid Intima-media Thickness and Overall Rigidity. Study Start Date :. April 2005. ...
more infohttps://clinicaltrials.gov/show/NCT00738296

Carotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts | StrokeCarotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts | Stroke

Carotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts. L.M. Cupini, P. Pasqualetti, M. Diomedi, F. ... The role of carotid artery intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128: 262-269. ... Carotid-artery intima media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999 ... Carotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts. L.M. Cupini, P. Pasqualetti, M. Diomedi, F. ...
more infohttp://stroke.ahajournals.org/content/33/3/689

Risk factors and utility of maximum carotid intima-media thickness as  | TCRMRisk factors and utility of maximum carotid intima-media thickness as | TCRM

Furthermore, the usefulness of maximum carotid intima-media thickness (maximum-IMT) as a surrogate marker of coronary artery ... Risk factors and utility of maximum carotid intima-media thickness as a surrogate marker for coronary artery stenosis Keiji ... Risk factors and utility of maximum carotid intima-media thickness as a surrogate marker for coronary artery stenosis. ... Furthermore, the usefulness of maximum carotid intima-media thickness (maximum-IMT) as a surrogate marker of coronary artery ...
more infohttps://www.dovepress.com/risk-factors-and-utility-of-maximum-carotid-intima-media-thickness-as--peer-reviewed-article-TCRM

Thicker carotid intima-media thickness and increased plasma VEGF level | IJGMThicker carotid intima-media thickness and increased plasma VEGF level | IJGM

This cross-sectional study aims at measuring the effect of atherosclerosis assessed through carotid intima-media thickness ( ... Thicker carotid intima-media thickness and increased plasma VEGF levels suffered by post-acute thrombotic stroke patients Yuyun ... Thicker carotid intima-media thickness and increased plasma VEGF levels suffered by post-acute thrombotic stroke patients. ... This cross-sectional study aims at measuring the effect of atherosclerosis assessed through carotid intima-media thickness ( ...
more infohttps://www.dovepress.com/thicker-carotid-intima-media-thickness-and-increased-plasma-vegf-level-peer-reviewed-article-IJGM

PRIME PubMed | [Association of blood pressure levels with carotid intima-media thickness and plaquesPRIME PubMed | [Association of blood pressure levels with carotid intima-media thickness and plaques

Association of blood pressure levels with carotid intima-media thickness and plaques were found in PRIME PubMed. Download Prime ... Common carotid artery intima-media thickness, carotid plaques, and walking speed.. *Which factors are related to the presence ... Relevance of common carotid intima-media thickness and carotid plaque as risk factors for ischemic stroke in patients with type ... Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness. ...
more infohttps://www.unboundmedicine.com/medline/citation/19806002/%5BAssociation_of_blood_pressure_levels_with_carotid_intima_media_thickness_and_plaques%5D_

Residential Exposure to Urban Traffic Is Associated with Increased Carotid Intima-Media Thickness in ChildrenResidential Exposure to Urban Traffic Is Associated with Increased Carotid Intima-Media Thickness in Children

Our study examined the association of long-term exposure to traffic with carotid intima-media thickness (cIMT) in 287 healthy ... Residential Exposure to Urban Traffic Is Associated with Increased Carotid Intima-Media Thickness in Children. Rodrigo X. ... and reproduction in any medium, provided the original work is properly cited. ...
more infohttps://www.hindawi.com/journals/jeph/2015/713540/abs/

Carotid Artery Intima-Media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in ChineseCarotid Artery Intima-Media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in Chinese

Carotid plaque measured by the degree of diameter stenosis was also significantly associated with increased risk of CHD (p for ... The corresponding RRs with internal carotid IMT were 1.47 (95% CI, 1.21-1.79) for CHD and 1.52 (95% CI, 1.31-1.76) for stroke. ... The multivariate relative risks (RRs) associated with a change of 1 standard deviation of maximal common carotid IMT were 1.38 ... Conclusions This prospective study indicates a significant association between carotid IMT and incidence of CHD and stroke in ...
more infohttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003435

Cytokine Polymorphisms Associated With Carotid Intima-Media Thickness in Stroke Patients | StrokeCytokine Polymorphisms Associated With Carotid Intima-Media Thickness in Stroke Patients | Stroke

Common carotid artery intima-media thickness and brain infarction. Circulation. 2000; 102: 313-318. ... Cytokine Polymorphisms Associated With Carotid Intima-Media Thickness in Stroke Patients. David Brenner, Julien Labreuche, ... Measuring carotid intima-media thickness (IMT) is a powerful technique for studying atherosclerosis. IMT is determined by ... OLeary D, Polak J, Kronmal P. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke ...
more infohttp://stroke.ahajournals.org/content/37/7/1691

Carotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension | HeartCarotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension | Heart

Carotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension ... Carotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension ... Intima-media thickness (IMT) is nowadays considered a validated and reproducible end point for atherosclerosis.3 The aim of the ... intima-media thickness. The significance of exercise blood pressure in post-coarctectomy patients and its relation to clinical ...
more infohttps://heart.bmj.com/content/91/7/962

PRIME PubMed | Does B-mode common carotid artery intima-media thickness differ from M-model?PRIME PubMed | Does B-mode common carotid artery intima-media thickness differ from M-model?

PubMed journal article Does B-mode common carotid artery intima-media thickness differ from M-model? were found in PRIME PubMed ... Individual measurement and significance of carotid intima, media, and intima-media thickness by B-mode ultrasonographic image ... The present study compares intima-media thickness of the common carotid artery measured with the two techniques. Intima-media ... The present study compares intima-media thickness of the common carotid artery measured with the two techniques. Intima-media ...
more infohttps://www.unboundmedicine.com/medline/citation/11731046/Does_B_mode_common_carotid_artery_intima_media_thickness_differ_from_M_model

Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive WomenEvaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women

"Normative values and correlates of carotid artery intima-media thickness and carotid atherosclerosis in Andean-Hispanics: the ... V. T. Kotsis, S. V. Stabouli, C. M. Papamichael, and N. A. Zakopoulos, "Impact of obesity in intima media thickness of carotid ... A. Z. Fan and J. H. Dwyer, "Sex differences in the relation of HDL cholesterol to progression of carotid intima-media thickness ... J. J. Cao, C. Thach, T. A. Manolio et al., "C-reactive protein, carotid intima-media thickness, and incidence of ischemic ...
more infohttps://www.hindawi.com/journals/ijhy/2012/257501/

Carotid Plaque, Intima-Media Thickness, and Incident Aortic StenosisSignificance | Arteriosclerosis, Thrombosis, and Vascular...Carotid Plaque, Intima-Media Thickness, and Incident Aortic StenosisSignificance | Arteriosclerosis, Thrombosis, and Vascular...

Carotid intima-media thickness (IMT) relates to the 2 innermost layers of the arterial wall: the intima and the media. The ... Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. Ann Epidemiol. ... Relationship between intima-media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation. Stroke ... Carotid intima-media thickness at different sites: Relation to incident myocardial infarction. Eur Heart J. 2002;23:934-940. ...
more infohttp://atvb.ahajournals.org/content/34/10/2343

Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes.  - PubMed -...Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. - PubMed -...

Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were evaluated before and after treatment ... Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes.. Mita T1, ... this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16616147?dopt=Abstract

Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. |...Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. |...

Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes.. ... Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. ... Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. ... Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. ...
more infohttps://care.diabetesjournals.org/content/23/9/1401

Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults AgedCommon Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged

... Eikendal, Anouk L M; Groenewegen, ... Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time ... Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time ... Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time ...
more infohttps://lup.lub.lu.se/search/publication/0face793-571e-48df-989a-fb4a12491af2

Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness | DiabetesSoluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness | Diabetes

Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of ... The IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European ... Sex-specific effects of adiponectin on carotid intima-media thickness and incident cardiovascular disease. J Am Heart Assoc ... Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European ...
more infohttps://diabetes.diabetesjournals.org/content/65/10/2888

Silent Cerebral Infarction is Associated with Incident Stroke and TIA Independent of Carotid Intima-Media ThicknessSilent Cerebral Infarction is Associated with Incident Stroke and TIA Independent of Carotid Intima-Media Thickness

Keywords: silent cerebral infarction, carotid intima-media thickness, incident stroke, cohort study, magnetic resonance imaging ... Background Both silent cerebral infarction (SCI) and carotid intima-media thickness (IMT) are associated with future stroke. We ... Both SCI and carotid IMT at baseline were associated with incident stroke/TIA events after adjustment for age, sex, and ... The predictive value of SCI remained significant even after adjustment for carotid IMT (HR 8.56; 1.72-42.55).. Conclusion SCI, ...
more infohttps://www.jstage.jst.go.jp/article/internalmedicine/49/9/49_9_817/_article

Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults |...Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults |...

Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults. Praveen ... Background: African Americans tend to have greater carotid intima-media thickness (IMT), and are 60% more likely to have a ... Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults ... Abstract 128: Six Months of Lifestyle Intervention Reduces Carotid Intima-media Thickness in African Merican Adults ...
more infohttp://hyper.ahajournals.org/content/60/Suppl_1/A128

Carotid intima-media thickness: studies into methodological aspectsCarotid intima-media thickness: studies into methodological aspects

Carotid artery intima-media thickness (CIMT) is widely used in observational and intervention studies. Despite the long history ... Carotid intima-media thickness: studies into methodological aspects. DSpace/Manakin Repository. Carotid intima-media thickness ... Completeness of CIMT data at different walls, segments and angles of the carotid artery was studied in a population with ...
more infohttps://dspace.library.uu.nl/handle/1874/30546

Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: the Healthy Twin Study.Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: the Healthy Twin Study.

... aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media ... Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study ... The intima-media thickness of common, carotid bifurcation, and internal carotid artery were measured using B-mode ultrasound. ... Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study aimed to ...
more infohttp://www.biomedsearch.com/nih/Segment-specific-carotid-intima-media/21914685.html
  • Multivariate stepwise regression analyses were used to identify independent predictors of common carotid IMT. (bmj.com)
  • Relationships of night/day heart rate ratio with carotid intima media thickness and markers of arterial stiffness. (biomedsearch.com)
  • 3) to assess the usefulness of combined carotid and femoral. (ebscohost.com)
  • The aim of our study was to assess the efficacy of 6 months of diet and exercise intervention on carotid IMT in sedentary African American adults. (ahajournals.org)
  • Since the clock for atherosclerosis starts ticking even before the onset of diabetes ( 4 ), it would be of interest to study whether structural changes, such as carotid intima-media thickness (IMT) ( 5 ), and functional changes, such as arterial stiffness ( 6 ), are associated with diabetic retinopathy. (diabetesjournals.org)
  • In summary, this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with type 2 diabetes. (nih.gov)
  • Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. (diabetesjournals.org)
  • Carotid IMT has been used in many epidemiological and clinical studies and these have shown associations with several risk factors, including type 2 diabetes, familial hypercholesterolemia, high-density lipoprotein cholesterol (HDL-C), triglycerides, rheumatoid arthritis, non-alcoholic fatty liver disease, and air pollution. (wikipedia.org)
  • RESULTS: Carotid intima media thickness, central and peripheral augmentation index, and ambulatory arterial stiffness index were negatively correlated to office and ambulatory heart rate and its standard deviation, and positively correlated to the night/day heart rate ratio. (biomedsearch.com)
  • We sought to explore the genetics of carotid IMT in brain infarction (BI) patients from the GENétique de l'Infarctus Cérébral (GENIC) study. (ahajournals.org)
  • Our preliminary study showed that 6 months of diet and exercise intervention reduced carotid IMT by ∼7.3% and improved the cardio-metabolic profile in sedentary African Americans. (ahajournals.org)
  • Although postprandial PG, pTG, and fasting LDL cholesterol levels were all independently correlated with carotid IMT, pTG levels had the strongest statistical influence (P = 0.002). (diabetesjournals.org)