Benign paraganglioma at the bifurcation of the COMMON CAROTID ARTERIES. It can encroach on the parapharyngeal space and produce dysphagia, pain, and cranial nerve palsies.
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
Traumatic injuries to the VAGUS NERVE. Because the vagus nerve innervates multiple organs, injuries in the nerve fibers may result in any gastrointestinal organ dysfunction downstream of the injury site.
Traumatic injuries to the HYPOGLOSSAL NERVE.
A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating)(see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11)
Small clusters of chemoreceptive and supporting cells located near the ARCH OF THE AORTA; the PULMONARY ARTERIES; and the CORONARY ARTERIES. The aortic bodies sense PH; CARBON DIOXIDE; and OXYGEN concentrations in the BLOOD and participate in the control of RESPIRATION. The aortic bodies should not be confused with the PARA-AORTIC BODIES in the abdomen (which are sometimes also called aortic bodies).
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYMPANICUM; AORTIC BODIES; and the female genital tract. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Familial carotid body tumors: a closer look. (1/77)

PURPOSE: A family spanning three generations with a history of familial carotid body tumors (CBTs) was studied, and previously proposed hypotheses of tumor characteristics and genetic mode of transmission were addressed. METHODS: Clinically occult lesions in adult subjects were detected by means of high-resolution computed tomography. RESULTS: A 60% incidence of bilaterality of CBTs associated with multiple paragangliomas was noted in the family studied. The genetic mode for CBTs in this family was not simple autosomal dominant transmission and appeared to be paternally directed with complete penetrance. CONCLUSION: In patients with familial CBTs, high-resolution computed tomography is recommended for early screening as a means of prompting diagnosis and definitive treatment, an approach that minimizes morbidity and facilitates surgical excision.  (+info)

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. (2/77)

Hereditary paraganglioma (PGL) is characterized by the development of benign, vascularized tumors in the head and neck. The most common tumor site is the carotid body (CB), a chemoreceptive organ that senses oxygen levels in the blood. Analysis of families carrying the PGL1 gene, described here, revealed germ line mutations in the SDHD gene on chromosome 11q23. SDHD encodes a mitochondrial respiratory chain protein-the small subunit of cytochrome b in succinate-ubiquinone oxidoreductase (cybS). In contrast to expectations based on the inheritance pattern of PGL, the SDHD gene showed no evidence of imprinting. These findings indicate that mitochondria play an important role in the pathogenesis of certain tumors and that cybS plays a role in normal CB physiology.  (+info)

Bilateral carotid body paraganglioma: case report. (3/77)

CONTEXT: Surgical treatment of carotid body paragangliomas is a challenge to the surgeon because of the large vascularization of the tumor, involvement of the carotid vessels and the close anatomical relationship with the cranial nerves. CASE REPORT: A 63-year-old patient was submitted to resection of two carotid body paraganglioma tumors found in the right-side and left-side carotid bodies at the bifurcation of the common carotid arteries. Two surgeries were performed at different times and neither of them presented any morbidity. Arteriography was fundamental for diagnosis of the small, asymptomatic tumor on the right side. DESIGN: Case Report  (+info)

Baroreflex failure syndrome after bilateral excision of carotid body tumors: an underestimated problem. (4/77)

Carotid body tumors (CBTs) are relatively rare paragangliomas that develop from neural crest cells at the bifurcation of the common carotid artery. They are generally slow growing and benign. Excision is currently considered the treatment of choice, although vascular and especially neural injuries are still relatively frequent in patients with large or bilaterally resected tumors. The baroreflex failure syndrome (BFS) has recently been identified as a severe, rarely recognized, and certainly underestimated complication after the bilateral excision of CBTs. The present report describes a case of a bilateral CBT followed by BFS and reviews the experiences reported in the literature. In light of the low incidence of malignancy of these tumors, their biologic behavior, their very high rate of cranial nerve palsy, and the occurrence of BFS in bilaterally resected paragangliomas, the current practice of bilaterally removing these tumors is questioned.  (+info)

Power Doppler scanning in the diagnosis of carotid body tumors. (5/77)

The aim of this work was to show contribution of power Doppler imaging in the diagnosis of the carotid body tumors. Six patients with a nontender mass beneath the mandibular angle were evaluated with gray scale and power Doppler sonography. Well-defined, solid, weakly hyperechoic masses were noted on gray scale sonography in the carotid bifurcation. Power Doppler sonography showed abundant flow, characterized as an intense blush, throughout the entire tumor in all patients. We believe that invasive and expensive diagnostic modalities are not necessary to evaluate carotid body tumors. Gray scale sonography and power Doppler imaging are sufficient for primary diagnosis of carotid body tumors.  (+info)

Malignant carotid body tumor: a case report. (6/77)

Carotid body tumors (CBTs) have an unpredictable history with no correlation between histology and clinical behavior. Of reported cases since 1891, local and distant metastases appear in approximately 10% of cases and remain the hallmark of malignancy. Currently, there are not enough data to support a single treatment regimen for malignant CBTs. The reported case demonstrates some unanswered issues with regard to malignant CBTs to include lymph node dissection, the need for carotid resection, and the role of radiation therapy. A 46-year-old pathologist underwent a resection of a Shamblin I CBT, to include jugular lymph node sampling, without complication. There was lymph node involvement, and tumor cells were found on the margins of the pathologic specimen. Subsequent carotid resection with reversed interposition saphenous vein graft and modified neck dissection were performed again without complication. Follow-up at 4 years has been uneventful. Diagnosis of CBTs with the use of magnetic resonance angiography, magnetic resonance imaging, color flow duplex scanning, and the role of arteriography are reviewed. The current treatment options are discussed with reference to primary lymph node sampling, carotid resection, and neck dissection in malignant cases. This case demonstrates that the unpredictable nature of CBTs and their malignant potential warrant aggressive initial local treatment to include jugular lymph node sampling and complete tumor resection.  (+info)

Long-term effects of carotid sinus denervation on arterial blood pressure in humans. (7/77)

BACKGROUND: After experimental carotid sinus denervation in animals, blood pressure (BP) level and variability increase markedly but normalize to preoperative levels within 10 to 14 days. We investigated the course of arterial BP level and variability after bilateral denervation of the carotid sinus baroreceptors in humans. METHODS AND RESULTS: We studied 4 women (age 41 to 63 years) who were referred for evaluation of arterial baroreflex function because of clinical suspicion of carotid sinus denervation attributable to bilateral carotid body tumor resection. The course of BP level and variability was assessed from repeated office and 24-hour ambulatory measurements (Spacelabs/Portapres) during 1 to 10 years of (retrospective) follow-up. Rapid cardiovascular reflex adjustments to active standing and Valsalva's maneuver were assessed. Office BP level increased from 132/86 mm Hg (range, 118 to 148/80 to 92 mm Hg) before bilateral surgery to 160/105 mm Hg (range, 143 to 194/90 to 116 mm Hg) 1 to 10 years after surgery. During continuous 24-hour noninvasive BP recording (Portapres), a marked BP variability was apparent in all 4 patients. Initial symptomatic hypotension on change to the upright posture and abnormal responses to Valsalva's maneuver were observed. CONCLUSIONS: Acute carotid sinus denervation, as a result of bilateral carotid body tumor resection, has a long-term effect on the level, variability, and rapid reflex control of arterial BP. Therefore, in contrast to earlier experimental observations, the compensatory ability of the baroreceptor areas outside the carotid sinus seems to be of limited importance in the regulation of BP in humans.  (+info)

Baroreflex control of muscle sympathetic nerve activity after carotid body tumor resection. (8/77)

Bilateral carotid body tumor resection causes a permanent attenuation of vagal baroreflex sensitivity. We retrospectively examined the effects of bilateral carotid body tumor resection on the baroreflex control of sympathetic nerve traffic. Muscle sympathetic nerve activity was recorded in 5 patients after bilateral carotid body tumor resection (1 man and 4 women, 51+/-11 years) and 6 healthy control subjects (2 men and 4 women, 50+/-7 years). Baroreflex sensitivity was calculated from changes in R-R interval and muscle sympathetic nerve activity in response to bolus injections of phenylephrine and nitroprusside. In addition, sympathetic responses to the Valsalva maneuver and cold pressor test were measured. The integrated neurogram of patients and control subjects contained a similar pattern of pulse synchronous burst of nerve activity. Baroreflex control of both heart rate and sympathetic nerve activity were attenuated in patients as compared with control subjects [heart rate baroreflex sensitivity: 3.68+/-0.93 versus 11.61+/-4.72 ms/mm Hg (phenylephrine, P=0.011) and 2.53+/-1.36 versus 5.82+/-1.94 ms/mm Hg (nitroprusside, P=0.05); sympathetic baroreflex sensitivity: 3.70+/-2.90 versus 7.53+/-4.12 activity/100 beats/mm Hg (phenylephrine, P=0.10) and 3.93+/-4.43 versus 15.27+/-10.03 activity/100 beats/mm Hg (nitroprusside, P=0.028)]. The Valsalva maneuver elicited normal reflex changes in muscle sympathetic nerve activity, whereas heart rate responses were blunted in the patients with bilateral carotid body tumor resection. Maximal sympathetic responses to the cold pressor test did not differ between the two groups. Denervation of carotid sinus baroreceptors as the result of bilateral carotid body tumor resection produces chronic impairment of baroreflex control of both heart rate and sympathetic nerve activity. During the Valsalva maneuver, loss of carotid baroreflex control of heart rate is less well compensated for by the extra carotid baroreceptors than the control of muscle sympathetic nerve activity.  (+info)

A carotid body tumor is a rare, usually noncancerous (benign) growth that develops in the carotid body, a small structure located near the bifurcation (fork) of the common carotid artery in the neck. The carotid body is part of the chemoreceptor system that helps regulate breathing and blood pressure by responding to changes in oxygen, carbon dioxide, and pH levels in the blood.

Carotid body tumors are also known as carotid body paragangliomas or chemodectomas. They typically grow slowly and may not cause any symptoms for many years. However, as they enlarge, they can cause a visible or palpable mass in the neck, along with symptoms such as difficulty swallowing, hoarseness, or voice changes. In some cases, carotid body tumors can compress nearby nerves or blood vessels, leading to more serious complications like stroke or nerve damage.

Treatment for carotid body tumors typically involves surgical removal of the growth, which may be performed using traditional open surgery or minimally invasive techniques such as endovascular surgery or robotic-assisted surgery. Radiation therapy and chemotherapy are generally not effective in treating these tumors. Regular follow-up care is important to monitor for recurrence or development of new tumors.

The carotid body is a small chemoreceptor organ located near the bifurcation of the common carotid artery into the internal and external carotid arteries. It plays a crucial role in the regulation of respiration, blood pressure, and pH balance by detecting changes in the chemical composition of the blood, particularly oxygen levels, carbon dioxide levels, and hydrogen ion concentration (pH).

The carotid body contains specialized nerve endings called glomus cells that are sensitive to changes in these chemical parameters. When there is a decrease in oxygen or an increase in carbon dioxide or hydrogen ions, the glomus cells release neurotransmitters such as acetylcholine and dopamine, which activate afferent nerve fibers leading to the brainstem's nucleus tractus solitarius. This information is then integrated with other physiological signals in the brainstem, resulting in appropriate adjustments in breathing rate, depth, and pattern, as well as changes in heart rate and blood vessel diameter to maintain homeostasis.

Dysfunction of the carotid body can lead to various disorders, such as hypertension, sleep apnea, and chronic lung disease. In some cases, overactivity of the carotid body may result in conditions like primary breathing pattern disorders or pseudohypoxia, where the body responds as if it is experiencing hypoxia despite normal oxygen levels.

Vagus nerve injuries refer to damages or traumas affecting the vagus nerve, which is the tenth cranial nerve (CN X) in the human body. This nerve plays a crucial role in the autonomic nervous system, regulating essential functions such as heart rate, respiratory rate, and digestion.

Vagus nerve injuries can occur due to various reasons, including trauma during surgical procedures, neck or head injuries, inflammation, compression, or tumors affecting the nerve. Symptoms of vagus nerve injuries may include:

1. Hoarseness or voice changes
2. Difficulty swallowing (dysphagia)
3. Pain in the throat or ear
4. Changes in heart rate and blood pressure
5. Nausea, vomiting, or abdominal pain
6. Shortness of breath or difficulty breathing

The severity and nature of symptoms can vary depending on the location and extent of the injury to the vagus nerve. Treatment for vagus nerve injuries typically involves addressing the underlying cause, such as surgical intervention, physical therapy, or medication to manage pain and inflammation. In some cases, recovery may be incomplete, leading to long-term complications or disabilities.

Hypoglossal nerve injuries refer to damages or impairments to the twelfth cranial nerve, also known as the hypoglossal nerve. This nerve is primarily responsible for controlling the movements of the tongue.

An injury to this nerve can result in various symptoms, depending on the severity and location of the damage. These may include:

1. Deviation of the tongue to one side when protruded (usually away from the side of the lesion)
2. Weakness or paralysis of the tongue muscles
3. Difficulty with speaking, swallowing, and articulation
4. Changes in taste and sensation on the back of the tongue (in some cases)

Hypoglossal nerve injuries can occur due to various reasons, such as trauma, surgical complications, tumors, or neurological disorders like stroke or multiple sclerosis. Treatment for hypoglossal nerve injuries typically focuses on managing symptoms and may involve speech and language therapy, exercises to strengthen the tongue muscles, and, in some cases, surgical intervention.

Horner syndrome, also known as Horner's syndrome or oculosympathetic palsy, is a neurological disorder characterized by the interruption of sympathetic nerve pathways that innervate the head and neck, leading to a constellation of signs affecting the eye and face on one side of the body.

The classic triad of symptoms includes:

1. Ptosis (drooping) of the upper eyelid: This is due to the weakness or paralysis of the levator palpebrae superioris muscle, which is responsible for elevating the eyelid.
2. Miosis (pupillary constriction): The affected pupil becomes smaller in size compared to the other side, and it may not react as robustly to light.
3. Anhydrosis (decreased sweating): There is reduced or absent sweating on the ipsilateral (same side) of the face, particularly around the forehead and upper eyelid.

Horner syndrome can be caused by various underlying conditions, such as brainstem stroke, tumors, trauma, or certain medical disorders affecting the sympathetic nervous system. The diagnosis typically involves a thorough clinical examination, pharmacological testing, and sometimes imaging studies to identify the underlying cause. Treatment is directed towards managing the underlying condition responsible for Horner syndrome.

Aortic bodies, also known as aortic arch chemoreceptors or simply as carotid and aortic bodies, are small clusters of nerve cells located near the bifurcation of the common carotid artery (carotid body) and in the wall of the aortic arch (aortic body). They are part of the peripheral chemoreceptor system that responds to changes in chemical composition of the blood, particularly to decreases in oxygen levels, increases in carbon dioxide levels, and changes in pH. These receptors send signals to the brainstem, which in turn regulates breathing rate and depth to maintain adequate gas exchange and acid-base balance in the body.

Paraganglioma is a rare type of tumor that develops in the nervous system, specifically in the paraganglia. Paraganglia are clusters of specialized nerve cells throughout the body that release hormones in response to stress or physical activity. Most paragangliomas are benign (noncancerous), but some can be malignant (cancerous) and may spread to other parts of the body.

Paragangliomas can occur in various locations, including the head and neck region (called "head and neck paragangliomas") or near the spine, abdomen, or chest (called "extra-adrenal paragangliomas"). When they develop in the adrenal glands, which are located on top of each kidney, they are called pheochromocytomas.

Paragangliomas can produce and release hormones such as epinephrine (adrenaline) and norepinephrine, leading to symptoms like high blood pressure, rapid heart rate, sweating, anxiety, and headaches. Treatment typically involves surgical removal of the tumor, along with medications to manage symptoms and control hormone levels before and after surgery.

Paraganglioma, extra-adrenal, is a type of rare tumor that develops in the nervous system's paraganglia, which are groups of specialized cells that are responsible for regulating blood pressure and other bodily functions. Unlike adrenal paragangliomas, which form in the adrenal glands located on top of the kidneys, extra-adrenal paragangliomas develop outside of the adrenal glands, in various locations along the sympathetic and parasympathetic nervous systems. These tumors can be functional or nonfunctional, meaning they may or may not produce hormones such as catecholamines (epinephrine, norepinephrine, and dopamine). Functional extra-adrenal paragangliomas can cause symptoms related to excessive hormone production, including hypertension, sweating, headaches, and rapid heartbeat. Treatment typically involves surgical removal of the tumor, along with preoperative preparation to manage potential hormonal imbalances.

Succinate dehydrogenase (SDH) is an enzyme complex that plays a crucial role in the process of cellular respiration, specifically in the citric acid cycle (also known as the Krebs cycle) and the electron transport chain. It is located in the inner mitochondrial membrane of eukaryotic cells.

SDH catalyzes the oxidation of succinate to fumarate, converting it into a molecule of fadaquate in the process. During this reaction, two electrons are transferred from succinate to the FAD cofactor within the SDH enzyme complex, reducing it to FADH2. These electrons are then passed on to ubiquinone (CoQ), which is a mobile electron carrier in the electron transport chain, leading to the generation of ATP, the main energy currency of the cell.

SDH is also known as mitochondrial complex II because it is the second complex in the electron transport chain. Mutations in the genes encoding SDH subunits or associated proteins have been linked to various human diseases, including hereditary paragangliomas, pheochromocytomas, gastrointestinal stromal tumors (GISTs), and some forms of neurodegenerative disorders.

The carotid arteries are a pair of vital blood vessels in the human body that supply oxygenated blood to the head and neck. Each person has two common carotid arteries, one on each side of the neck, which branch off from the aorta, the largest artery in the body.

The right common carotid artery originates from the brachiocephalic trunk, while the left common carotid artery arises directly from the aortic arch. As they ascend through the neck, they split into two main branches: the internal and external carotid arteries.

The internal carotid artery supplies oxygenated blood to the brain, eyes, and other structures within the skull, while the external carotid artery provides blood to the face, scalp, and various regions of the neck.

Maintaining healthy carotid arteries is crucial for overall cardiovascular health and preventing serious conditions like stroke, which can occur when the arteries become narrowed or blocked due to the buildup of plaque or fatty deposits (atherosclerosis). Regular check-ups with healthcare professionals may include monitoring carotid artery health through ultrasound or other imaging techniques.

Chemoreceptor cells are specialized sensory neurons that detect and respond to chemical changes in the internal or external environment. They play a crucial role in maintaining homeostasis within the body by converting chemical signals into electrical impulses, which are then transmitted to the central nervous system for further processing and response.

There are two main types of chemoreceptor cells:

1. Oxygen Chemoreceptors: These cells are located in the carotid bodies near the bifurcation of the common carotid artery and in the aortic bodies close to the aortic arch. They monitor the levels of oxygen, carbon dioxide, and pH in the blood and respond to decreases in oxygen concentration or increases in carbon dioxide and hydrogen ions (indicating acidity) by increasing their firing rate. This signals the brain to increase respiratory rate and depth, thereby restoring normal oxygen levels.

2. Taste Cells: These chemoreceptor cells are found within the taste buds of the tongue and other areas of the oral cavity. They detect specific tastes (salty, sour, sweet, bitter, and umami) by interacting with molecules from food. When a tastant binds to receptors on the surface of a taste cell, it triggers a series of intracellular signaling events that ultimately lead to the generation of an action potential. This information is then relayed to the brain, where it is interpreted as taste sensation.

In summary, chemoreceptor cells are essential for maintaining physiological balance by detecting and responding to chemical stimuli in the body. They play a critical role in regulating vital functions such as respiration and digestion.

Carotid stenosis is a medical condition that refers to the narrowing or constriction of the lumen (inner space) of the carotid artery. The carotid arteries are major blood vessels that supply oxygenated blood to the head and neck. Carotid stenosis usually results from the buildup of plaque, made up of fat, cholesterol, calcium, and other substances, on the inner walls of the artery. This process is called atherosclerosis.

As the plaque accumulates, it causes the artery to narrow, reducing blood flow to the brain. Severe carotid stenosis can increase the risk of stroke, as a clot or debris from the plaque can break off and travel to the brain, blocking a smaller blood vessel and causing tissue damage or death.

Carotid stenosis is typically diagnosed through imaging tests such as ultrasound, CT angiography, or MRI angiography. Treatment options may include lifestyle modifications (such as quitting smoking, controlling blood pressure, and managing cholesterol levels), medications to reduce the risk of clots, or surgical procedures like endarterectomy or stenting to remove or bypass the blockage.

Head and neck neoplasms refer to abnormal growths or tumors in the head and neck region, which can be benign (non-cancerous) or malignant (cancerous). These tumors can develop in various sites, including the oral cavity, nasopharynx, oropharynx, larynx, hypopharynx, paranasal sinuses, salivary glands, and thyroid gland.

Benign neoplasms are slow-growing and generally do not spread to other parts of the body. However, they can still cause problems if they grow large enough to press on surrounding tissues or structures. Malignant neoplasms, on the other hand, can invade nearby tissues and organs and may also metastasize (spread) to other parts of the body.

Head and neck neoplasms can have various symptoms depending on their location and size. Common symptoms include difficulty swallowing, speaking, or breathing; pain in the mouth, throat, or ears; persistent coughing or hoarseness; and swelling or lumps in the neck or face. Early detection and treatment of head and neck neoplasms are crucial for improving outcomes and reducing the risk of complications.

with Zoë D. Chamberlain: Chamberlain, Zoë D.; Hunt, T. C. (March 1961). "Carotid body tumour associated with diarrhoea and ...
A paraganglioma is a tumor that may involve the carotid body and is usually benign. Rarely, a malignant neuroblastoma may ... The carotid body is situated on the posterior aspect of the bifurcation of the common carotid artery. The carotid body is made ... originate from the carotid body. List of distinct cell types in the adult human body "Carotid Body and Carotid Sinus -- General ... Impulse rate for carotid bodies is particularly sensitive to changes in arterial PO2 in the range of 60 down to 30 mm Hg, a ...
Carotid paraganglioma (carotid body tumor): Is the most common of the head and neck paragangliomas. It usually presents as a ... Micrograph of a carotid body tumor Glomus jugulare tumor Ectopic functional paraganglioma (glomus jugulare) in a patient with ... particularly in the carotid bodies (at the bifurcation of the common carotid artery in the neck) and in aortic bodies (near the ... S100 immunostain highlighting the sustentacular cells in a paraganglioma Digital subtraction arteriogram of carotid body tumor ...
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... tumor Coccygeal glomus Carotid glomus, another name for the carotid body Glomus cell Glomerulus, an anatomical term ...
... is a tumor that may involve an aortic body. Swelling can also occur.[vague] Carotid body Control of respiration Peripheral ... Aortic bodies are more sensitive detectors of total arterial blood oxygen content than the carotid body chemoreceptors, which ... Some sources equate the "aortic bodies" and "paraaortic bodies", while other sources explicitly distinguish between the two. ... "Expanding role of ATP as a versatile messenger at carotid and aortic body chemoreceptors". The Journal of Physiology. 591 (2): ...
Paragangliomas Stroke Spinal vascular malformations Traumatic vascular lesions Vasospasm Vertebral body tumors Vertebral body ... The first treatment was performed in 1970 in Moscow, with the occlusion of an internal carotid to treat a carotid-cavernous ... and paraspinal vascular malformations Head and neck tumors Intracranial atherosclerosis Juvenile nasopharyngeal tumor ... He performed the first brain angiography in Lisbon in 1927 by injecting an iodinated contrast medium into the internal carotid ...
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Nonchromaffin paraganglia include carotid bodies and aortic bodies, some are distributed in the ear, along the vagus nerve, in ... Tumors of the paraganglionic tissues are known as paragangliomas, though this term tends to imply the nonchromaffin type, and ... They are generally present at the head and neck, most often at carotid body or jugulo-tympanic, they rarely secrete hormones ... WHO classification of tumors (2005). "Tumours of the Paraganglionic System". Pathology and genetics of head and neck tumours ( ...
... is a tumor suppressor gene. Constitutional mutations in this gene cause hereditary paraganglioma, a neuroendocrine tumor ... Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the ... and may develop at various body sites, including the head, neck, thorax and abdomen. ... a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism". Endocrine. 38 (3): 397-401. doi: ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates ... Most all meningiomas grow very slowly and almost never metastasize to other parts of the body. In part because of its slow ... especially the carotid artery) or cranial nerves, risks that are lower with radiosurgery. If surgery is done and the entire ... If the tumor continues to grow and push on the optic nerve, all vision will be lost in that eye as the nerve atrophies. ...
Third-order neuron disorder: Postganglionic lesions at the level of the internal carotid artery (e.g. a tumor in the cavernous ... If patients have impaired sweating above the waist affecting only one side of the body, and they do not have clinically ... such as a Pancoast tumor (tumor in the apex of the lung) or thyrocervical venous dilatation).[citation needed] Causes can be ... An episode of Horner's syndrome may occur during a migraine attack and be relieved afterwards Carotid artery dissection/carotid ...
... carotid body tumor MeSH C04.557.465.625.650.700.705.340 - glomus jugulare tumor MeSH C04.557.465.625.650.700.705.360 - glomus ... carotid body tumor MeSH C04.557.580.625.650.700.705.340 - glomus jugulare tumor MeSH C04.557.580.625.650.700.705.360 - glomus ... sertoli-leydig cell tumor MeSH C04.557.475.750.847.249 - leydig cell tumor MeSH C04.557.475.750.847.500 - sertoli cell tumor ... mixed tumor, malignant MeSH C04.557.435.530 - mixed tumor, mesodermal MeSH C04.557.435.540 - mixed tumor, mullerian MeSH ...
Jugular/jugulotympanic paranglioma M8691/1 Aortic body tumor (C75.5) Aortic/aorticopulmonary paraganglioma M8692/1 Carotid body ... NOS G cell tumor, NOS Gastrin cell tumor M8153/3 Gastinoma, malignant G cell tumor, malignant Gastrin cell tumor, malignant ... Hilar cell tumor M8670/0 Lipid cell tumor of ovary (C56.9) Lipoid cell tumor of ovary Steroid cell tumor, NOS ... tumor of intermediate differentiation Transitional pineal tumor M9363/0 Melanotic neuroectodermal tumor Retinal anlage tumor ...
2006). "Are small renal tumors harmless? Analysis of histopathological features according to tumors 4 cm or less in diameter". ... 2005). "Whole-body CT screening: spectrum of findings and recommendations in 1192 patients". Radiology. 237 (2): 385-94. doi: ... of patients undergoing bilateral carotid duplex ultrasonography. The American College of Radiology recommends the following ... Tumors less than 3 cm in diameter less frequently have aggressive histology. A CT scan is the first choice modality for workup ...
He was the first physician to remove a spinal tumor, in 1887, by means of a laminectomy. He developed many practical ... Mary Sturge, he published a book on alcoholism titled Alcohol and the Human Body. According to his biographers, Tan & Black ( ... neurosurgical techniques, including the hemostatic bone wax, the skin flap, the ligation of the carotid artery to treat ... and Alcohol and the Human Body (1902). Horsley was a Liberal Party supporter and contested the December 1910 General election ...
He was able to identify all the parts of his body and distinguish right from left on his own body, and his initial belief that ... Further testing, radio isotope scintigraphy, revealed the spread of a left parietal occipital tumor a week after. Once fully ... middle and left parietal veins through bilateral carotid angiography. ... Hemiasomatognosia A patient cannot focus attention on the left side of the body and believes that this side of the body feels " ...
This is based on the high amounts of tumor suppressor gene p53 mutations and k-ras arginine mutations found in patients with ... This suppresses the immune system stopping the body from recognising the cancerous cells and as a result more cancer-promoting ... coronary and carotid arteries. It has been recognised that there is an association between oral and intestinal cancer related ... Öğrendik M (March 2017). "Periodontal Pathogens in the Etiology of Pancreatic Cancer". Gastrointestinal Tumors. 3 (3-4): 125- ...
... or tumors starting at the base of the brain, such as meningioma. Due to the sensitive location, nosebleeds caused by tumors are ... More rarely the maxillary or a branch of the external carotid artery can be ligated. The bleeding can also be stopped by intra- ... Foreign bodies (such as fingers during nose-picking) Digital trauma (nose picking) Middle ear barotrauma (such as from descent ... Vascular Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) Angioma Aneurysm of the carotid artery The nasal ...
... pituitary tumors or pituitary apoplexy, aneurysms of the intracavernous carotid artery, carotid-cavernous fistula, bacterial ... Above: optic tract, optic chiasma, internal carotid artery. Inferiorly: foramen lacerum, and the junction of the body and ... The carotid siphon of the internal carotid artery, and cranial nerves III, IV, V (branches V1 and V2) and VI all pass through ... Abducens nerve Internal carotid artery accompanied by the internal carotid plexus These nerves, with the exception of CN V2, ...
Tumors arising from these cell are called paragangliomas or pheochromocytomas. These terms can be used interchangeably but ... List of distinct cell types in the adult human body List of human cell types derived from the germ layers Schober, Andreas; ... Chromaffin cells also settle near the vagus nerve and carotid arteries. In lower concentrations, extra-adrenal chromaffin cells ... Following heart failure, the body increases sympathetic activity to the adrenal medulla as the compensatory mechanism to ...
Lattes, R., McDonald, J.J., Sproul, E.E. (1954) Non-chromaffin paraganglioma, of carotid body and orbit; report of a case. ... Fiala, S., Sproul, E.E., Blutinger, M.E., Fiala, A.E. (1955) Basophilic chromidia and mitochondria in normal and in tumor ...
... as novel targeted therapies can extend tumor control considerably, while also leading to tumor burden decrease and potentially ... Other symptoms include cough, neck pain, or symptoms from the spread of cancer to distant sites in the body, such as the brain ... ATC commonly causes symptoms by compressing local structures, such as the esophagus, carotid arteries, recurrent laryngeal ... Anaplastic tumors have a high mitotic rate and frequently invades the local blood and lymphatic vessels. Cellular death is ...
The glomus body is not to be confused with the glomus cell which is a kind of chemoreceptor found in the carotid bodies and ... Glomus tumor Standring, Susan (2016). Gray's anatomy : the anatomical basis of clinical practice (Forty-first ed.). [ ... Glomus bodies (glomera) are most numerous in the fingers and toes. The role of the glomus body is to shunt blood away (heat ... A glomus body (or glomus organ) is a component of the dermis layer of the skin, involved in body temperature regulation. The ...
When abnormal cells group together in the body, they are said to form a tumor. Tumors can be either malignant (cancerous) or ... carotid endartectomy, vagal nerve stimulator implantation), injection of botulinum neurotoxin, or penetrating neck trauma. ... are performed to exclude tumors along the laryngeal nerves. When tumor formation is suspected, parts of the hypopharynx and the ... Tumors of the vagus nerve, called vagal neurilemmomas, can also paralyze the vocal folds. VF paresis can result from trauma to ...
... the carotid sheath, or the structures within the carotid sheath. T1: Tumour only involves the vocal cords. Vocal cords have ... Tumour meets ALL of the following criteria: involves single lymph node involved lymph node on the same side of the body as ... In most cases, tumour staging is completed by scanning the head and neck region to assess the local extent of the tumour and ... T2: Tumour invades mucosa. There is no fixation of the larynx. T3: Tumour causes fixation of the vocal cords, with or without ...
This procedure is used when the tumor does not have clear boundaries and the surgeon wants to know if they are invading on ... Generally once a disc is removed it is replaced by an implant which will create a bony fusion between vertebral bodies above ... Microvascular techniques are used in EC-IC bypass surgery and in restoration carotid endarterectomy. The clipping of an ... History of tumor removal: In 1879, after locating it via neurological signs alone, Scottish surgeon William Macewen (1848-1924 ...
The signs and symptoms of ischemia vary, as they can occur anywhere in the body and depend on the degree to which blood flow is ... Hypotension (low blood pressure, e.g. in septic shock, heart failure) Outside compression of a blood vessel, e.g. by a tumor or ... Acute arterial occlusion may develop as a result of arterial dissection in the carotid artery or aorta or as a result of ... Decrease in body temperature reduces the aerobic metabolic rate of the affected cells, reducing the immediate effects of ...
The sphenoid sinus is a paired paranasal sinus occurring within the body of the sphenoid bone. It represents one pair of the ... A potential complication of sphenoidal sinusitis is cavernous sinus thrombosis.[citation needed] If a fast-growing tumor erodes ... internal carotid artery, cavernous sinus, trigeminal nerve, pituitary gland, and the anterior ethmoidal cells.: 500 The ... Each spehoid sinus is contained within the body of sphenoid bone, being situated just inferior to the sella turcica. The two ...
The other approach would potentially use minuscule nanoparticles that would travel through the body and find dying heart tissue ... the left carotid artery) at a rate that was twice the amount of the non-targeted nanoparticles ("MIT-Massachusetts Institute of ... specifically designed for targeting the environments of tumors, phagosomes, and inflammatory tissue. In such acidic ... and its job is to protect the drug from disintegrating while it is traveling through the body. The middle layer consists of a ...
These tumors develop within the adventitia of the medial aspect of the carotid bifurcation. ... Carotid body tumors (CBTs) are rare neoplasms, although they represent about 65% of head and neck paragangliomas. ... Carotid body tumors (CBTs) can occur in children; however, carotid body tumors (CBTs) are considered to be a disease of middle ... Management of carotid body tumors. Carotid body tumors (CBTs) are treated with either surgery or radiotherapy. When choosing ...
Carotid body tumors are growths in the blood vessels near your carotid arteries. Healthcare providers typically use surgery to ... of carotid body tumors are malignant (cancerous).. Who can get carotid body tumors?. Anyone can get a carotid body tumor. The ... Carotid Body Tumors. Carotid body tumors are growths in the blood vessels near your carotid arteries. These growths are ... A carotid body tumor is also called a carotid body paraganglioma or a carotid body chemodectoma. ...
We report on the preoperative embolization of a carotid-body paraganglioma by temporary balloon occlusion and ethanol injection ... Temporary balloon occlusion and ethanol injection for preoperative embolization of carotid-body tumor Ear Nose Throat J. 2002 ... This procedure is an effective and promising method of preoperative embolization of carotid-body tumors and warrants further ... In this article, we also review the literature on carotid-body tumor embolization and ethanol embolization. ...
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I was just diagnosed with paraganglioma and carotid body tumor. My doctor has referred me for a biopsy prior to referring me to ... I did a quick internet search for carotid body tumor and biopsy and found this statement. The diagnosis of carotid body tumor ... I did a quick internet search for carotid body tumor and biopsy and found this statement. The diagnosis of carotid body tumor ... I was just diagnosed with paraganglioma and carotid body tumor. My doctor has referred me for a biopsy prior to referring me to ...
The carotid body is a group of cells located at the bifurcation of the internal and external carotid arteries. This very small ... The carotid body is a group of cells located at the bifurcation of the internal and external carotid arteries. This very small ... If the tumor is large, your vascular surgeon can embolize the tumor to shrink it prior to surgery. The tumor can then be ... Infrequently, these tumors run in families and can be malignant. However, most of the time these are benign, sporadic tumors. ...
Multi-institutional survey of carotid body tumors in Japan. Aya Ikeda, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Jun ... Dive into the research topics of Multi-institutional survey of carotid body tumors in Japan. Together they form a unique ...
Surgical management of carotid body tumors. Grage, T. B.; Cueto, J. Grage, T. B.; Cueto, J. Less ... Radio therapy in the treatment of the primary tumor in penile cancer. Knudsen, O. S.; Brennhovd, I. O. ...
... we have evaluated the various characteristics of this relatively rare tumor in our population and compared our results with ... In this report of 20 patients with 24 carotid body tumors which is the largest series reported so far from Iran, ... In this report of 20 patients with 24 carotid body tumors which is the largest series reported so far from Iran, we have ... We propose the surgical technique detailed by the author as the method of choice for treatment of carotid body tumors in ...
Explore a rare case of multiple paraganglioma with 5 locations and discover a unique complication of spontaneous tumor bleeding ... Glomus Tumor; Paraganglioma; Glomus Jugulare; Carotid Body Tumor; Postoperative Complications Share and Cite: ... bilateral carotid body and bilateral brachiocephalic trunk) through imaging studies. She reported suffering relatives of ... Surgical Management of Glomus Jugulare Tumors: A Proposal for Approach Selection Based on Tumor Relationships with the Facial ...
with Zoë D. Chamberlain: Chamberlain, Zoë D.; Hunt, T. C. (March 1961). "Carotid body tumour associated with diarrhoea and ...
Carotid Body Tumor ... Carotid Endarterectomy (CEA) or Excision of Infected Graft ... View other providers who treat Carotid Endarterectomy (CEA) or Excision of Infected Graft ...
Chapter 7. Carotid Body Tumors, Paragangliomas and Vascular Anomalies. Tammara Watts, MD¹ and Davud Sirjani, MD². ¹Department ... Tumors of the Oral Cavity and Pharynx. Richard Smith, MD, FACS¹ and Amy Hessel, MD². ¹Department of Otorhinolaryngology-Head ... Tumors of the Larynx, Hypopharynx, and Cervical Esophagus. Ameya A. Jategaonkar, MD¹; Timothy Blood, MD²; Dinesh K. Chhetri MD² ... Skull Base and Sinonasal Tumors. Janet Chao, MD¹; Thad Vickery, MD²; Michelle Chen, MD MHS³; R. Peter Manes, MD¹; and Daniel M ...
Resection of Carotid Body Tumors. *Retrieval of Inferior Vena Cava Filters. *Screening and Testing ... Aortic aneurysm, aortic dissection, aortoiliac occlusive disease, lower extremity arterial disease, carotid artery disease, ... carotid artery disease, mesenteric arterial disease, thoracic outlet syndrome, dialysis access, minimally invasive and medical ...
Carotid Body Tumor. Part IX: Malignant Pathology. 107. Excision of Facial Skin Malignancy. 108. Local Flaps for Facial ... Maxillectomy for Benign Tumors. 97. Segmental Resection of the Mandible. 98. Sublingual Gland Excision and Ductal Surgery. 99. ... Mandibular Body Fractures. 77. Mandibular Angle and Ramus Fractures. 78. Mandibular Condyle Fractures. 79. Atrophic Edentulous ...
They are included in a group of tumors referred to as paragangliomas, which occur at various sites and include carotid body, ... hypervascular tumors that arise within the jugular foramen of the temporal bone. ... Rosenwasser H. Carotid body tumor of the middle ear and mastoid. 1945. 41:64-67. ... Tumor volume following surgery was unchanged in 13 patients and was decreased in 8; tumor regrowth occurred in 1 patient. Tumor ...
A carotid body tumor mimicking a thyroid nodule: a case report. Baser Husniye , Ayhan Baris , Karanis Meryem Ilkay Eren , Baser ... We will present a case of PGL (a carotid body tumor) that we initially evaluated as a thyroid nodule, and then diagnosed as a ... 4 cm right upper lobe tumor, and 2 cm left lower lobe tumor. Owing to a mild coarsening of facial features, acromegaly was ... Brown tumors: the first and the final manifestation of primary hyperparathyroidism.. Sztembis Joanna , Orlowska-Florek Renata , ...
A rare case of malignant metastatic tumor diagnosed on fine-needle aspiration of cervical lymph node ... Dickinson PH, Griffin SM, Guy AJ, McNeill IF, . Carotid body tumour: 30 years experience. Br J Surg. 1986;73:14-6. [Google ... Williams MD, Phillips MJ, Nelson WR, Rainer WG, . Carotid body tumor. Arch Surg. 1992;127:963-7. [Google Scholar] ... Das DK, Gupta AK, Chowdhury V, Satsangi DK, Tyagi S, Mohan JC, . Fine-needle aspiration diagnosis of carotid body tumor: Report ...
Diagnosis of Carotid Body Tumors. A carotid body tumor is suspected if a pulsatile mass in the neck is observed. A CT, MRI, and ... These tumors are diagnosed by careful examination of the eardrum. The tip of the tumor can be seen through the translucent ... Glomus tympanicum tumors are small sized tumors originating in the middle ear.. *Glomus jugulare arise from paraganglia in or ... Usually, the entire perimeter of the tumor cannot be visualized. A CT scan and MRI scan are used to assess the extent of tumor ...
Management of carotid body tumor: thirteen years of experience. Rasoul MIRSHARIFI, Alireza MIRSHARIFI, Camellia AZIMARAGHI, ...
Ultrasound Evaluation of Carotid Body Tumor Faculty: Brian Schenker MBA, RDMS, RVT ... Ultrasound Institute is recognized as a worldwide leader in Vascular Ultrasound continuing medical education covering Carotid ...
Indium In-111 pentetreotide scintigraphy: application to carotid body tumors. Hammond, S.L., Greco, D.L., Lambert, A.T., ... Indium In-111 pentetreotide scintigraphy: application to carotid body tumors [10].. *OBJECTIVE: To evaluate therapy with high ... Comparison of In-111 pentetreotide, Tc-99m (V)DMSA and I-123 mlBG scintimaging in neural crest tumors. Limouris, G.S., ... Ocular metastases secondary to carcinoid tumors: the utility of imaging with [(123)I]meta-iodobenzylguanidine and [(111)In]DTPA ...
Ultimately, this caused a carotid body tumour, known as a paraganglioma. The tumour has since successfully been removed and my ...
Paraganglioma, Paraganglia, Chromaffin, Carotid Body Tumor, Nuclear Medicine Hemangioma gigante da parede torácica: localização ...
The carotid body tumor. Vrancken Peeters, M. P. F. M., Hendriks, J. M., Rouwet, E. V., Van Sambeek, M. R. H. M., Van Urk, H. & ...
Carotid body tumor, Deep vein thrombosis, Vascular graft infection, Median arcuate ligament syndrome, Aortoiliac disease, ... Mesenteric artery bypass, Thoracoabdominal aneurysm surgery, Femoral endarterectomy, Carotid angioplasty and stenting, ... ... Carotid artery dissection, Peripheral artery disease, Critical limb ischemia, Vascular anomaly, Abdominal aortic aneurysm, ... Carotid artery disease, Venous malformation, Aortic ulcer, Popliteal artery entrapment syndrome, Arteriovenous malformation, ...
The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers to the color the ... tumor cells acquire when stained with chromium salts. ... Mutations in this gene are known to cause carotid body tumors ... However, paternal imprinting appears to be the inheritance pattern in paragangliomas and, in particular, carotid body tumors ... The tumors most commonly associated with hemihyperplasia are Wilms tumor and hepatoblastoma, but at least one patient has been ...
... pituitary and neuro-endocrine specialists believe patient education is vital for the successful treatment of pituitary tumors ... Carotid Body Tumor. Congenital Adrenal Hyperplasia. Craniopharyngioma. A craniopharyngioma is a rare type of brain tumor that ... Pituitary Tumors. A pituitary tumor, or pituitary adenoma, is an abnormal growth of cells within or around… ... Are pituitary tumors hereditary? Barrow neuro-endocrinologist, Kevin Yuen, MD, discusses the likelihood of tumors being ...
Carotid body tumors (synonymus che-modectoma, carotis tumor. glomus carotica) are tu-mors arising from chemoreceptor ... Due to their low incidence these tumors are not habitually found in daily practices. We present a case of carotid body tumor ... CarotId Body Tumors. Karotis tümörIeri kemoreseptor paraganglioma hiicrelerinden menşe alırlar. Bu hücreler crista no-ralisten ... Recent studies have revealed that TRIP13 may be a potential tumor inducer in many cancers, including glioblastoma multiforme ( ...
Carotid Body Tumour Embolization Chronic Cerebrospinal Venous Insufficiency Resective Epilepsy Surgery (Pediatric Epilepsy ...
  • A carotid body tumor is also called a carotid body paraganglioma or a carotid body chemodectoma. (
  • We report on the preoperative embolization of a carotid-body paraganglioma by temporary balloon occlusion and ethanol injection. (
  • I was just diagnosed with paraganglioma and carotid body tumor. (
  • The diagnosis of carotid body tumor, also known as a chemodectoma or paraganglioma, is typically made with radiological studies. (
  • Objective: To report a case of a multiple paraganglioma with 5 concurrent locations and also describe a complication not found in the literature, spontaneous tumor bleeding. (
  • Köhler, H.F., Carvalho, A.L., Nishinari, K. and Kowalski, L.P. (2010) Internal Carotid Artery Reconstruction after Paraganglioma Resection: Report of Six Cases and Analysis of Available Techniques. (
  • On the basis of characteristic cytological features, a diagnosis of metastatic neuroendocrine tumor/paraganglioma was suggested. (
  • She underwent surgery, and resection of the tumor with neck dissection was performed, which was reported as malignant carotid body paraganglioma on histopathology. (
  • Ultimately, this caused a carotid body tumour, known as a paraganglioma. (
  • Parasympathetic PGLs are most often nonsecreting, although about 30% are associated with elevated levels of the dopamine metabolite 3-methoxytyramine (3-MT). [ 5 ] Pheochromocytoma (PHEO) and sympathetic paraganglioma (SPGL) are catecholamine-secreting tumors. (
  • Carotid body tumors (CBTs) are rare neoplasms, although they represent about 50-60% of head and neck paragangliomas. (
  • When choosing treatment, consider the following factors: the presence of other paragangliomas, the presence of bilateral carotid body tumors (CBTs), the age and the health of the patient, and the patient's preference. (
  • [ 9 ] Carotid body tumors (CBTs) constitute about 50-60% of head and neck paragangliomas. (
  • Compared with unembolized and polyvinyl-alcohol-embolized carotid-body paragangliomas, our technique resulted in no greater adverse effects on the tumor-vessel interface. (
  • Ask your doctor if he or she regularly treats people with this condition, as most doctors rarely (if ever) encounter paragangliomas and are unfamiliar with the best approaches to diagnosing and treating this rare tumor. (
  • Under such conditions, it's important to seek a second opinion from a team that specializes in the care of people with rare neuroendocrine tumors such as paragangliomas. (
  • Case report: A female patient of 32 years old complaining of tinnitus and diagnosed with five paragangliomas (jugulo-timpanic, bilateral carotid body and bilateral brachiocephalic trunk) through imaging studies. (
  • When such tumors arise outside of the adrenal gland, they are termed extra-adrenal pheochromocytomas, or paragangliomas. (
  • Of extra-adrenal tumors, known as paragangliomas, 30% are malignant. (
  • Paragangliomas (PGLs) are rare neuroendocrine tumors that carry the highest degree of heritability among human neoplasms. (
  • Head and neck paragangliomas (HNPGLs) emerge from the parasympathetic nervous systemand are usually benign, slow-growing tumors. (
  • In the United States, the earliest successful carotid body tumor resection was performed by Scudder in 1903. (
  • Hayes Martin, in his textbook of head and neck tumors, recommended against resection of any tumor that is now considered a Shamblin type III (see Staging). (
  • A large retrospective, multicenter, international study analyzed the long-term outcome in 132 patients with primary radiation treatment or radiation after partial resection of a glomus tumor. (
  • Surgical resection of the tumor is the treatment of choice and usually cures the hypertension. (
  • Some studies estimate that less than 10% of carotid body tumors are malignant (cancerous). (
  • Infrequently, these tumors run in families and can be malignant. (
  • The average tumor size was 5.3 cm in diameter and was found to be malignant in four cases. (
  • Among the features that suggest a malignant course are large tumor size and an abnormal DNA ploidy pattern (aneuploidy, tetraploidy). (
  • In general, larger tumors are more likely to be malignant. (
  • Overview of Multiple Endocrine Neoplasias (MEN) The multiple endocrine neoplasia (MEN) syndromes comprise 4 genetically distinct familial diseases involving adenomatous hyperplasia and malignant tumors in several endocrine glands. (
  • Von Hippel-Lindau Disease (VHL) Von Hippel-Lindau disease is a rare hereditary neurocutaneous disorder characterized by benign and malignant tumors in multiple organs. (
  • The case report presents a rare occurrence of a carotid body tumour that has become malignant and metastised to various body systems. (
  • The tumor is malignant in 10% of cases but may be cured completely by surgical removal. (
  • Computed tomography (CT) scanning of the head and neck is also helpful and typically reveals a hypervascular tumor located between the external and internal carotid arteries. (
  • Carotid body tumors are growths in the blood vessels near your carotid arteries. (
  • A carotid body tumor is a mass that grows in the blood vessels near the large arteries in either side of your neck (carotid arteries). (
  • The carotid body is a group of cells located at the bifurcation of the internal and external carotid arteries. (
  • This requires a neck incision and possible excision of part of the carotid arteries. (
  • On color Doppler evaluation, the lesion was observed to lie between the internal and external carotid arteries. (
  • Shamblin's classification is based on the relationship between tumor and carotid arteries, which has limitations. (
  • Including both the horizontal relationship to carotid arteries and vertical extension of the tumors, PUMCH (Peking union medical college hospital) classification can better predict surgical complications and guide the surgery and thus might help to improve the surgical outcomes of the lesions. (
  • The carotid arteries provide the main blood supply to your brain. (
  • The tumor was as equally frequent on the right as it was on the left, and was bilateral in four cases. (
  • If the tumor is large, your vascular surgeon can embolize the tumor to shrink it prior to surgery. (
  • Gulfcoast Ultrasound Institute is recognized as a worldwide leader in Vascular Ultrasound continuing medical education covering Carotid Ultrasound, Peripheral Vascular Sonography, and Transcranial Doppler Imaging. (
  • Go to the Neuroendocrine Tumors (NETs) Support Group. (
  • [ 10 ] SDH- associated syndromes are characterized by the development of PGLs, with an additional risk for developing other tumor types [ e.g. , clear cell renal cancer (RCC), gastrointestinal stromal tumors (GISTs), and, more rarely, neuroendocrine tumors and pituitary adenomas]. (
  • [ 1 ] These tumors develop within the adventitia of the medial aspect of the carotid bifurcation. (
  • CECT revealed, in addition, a lobulated, ill-marginated enhancing space-occupying mass in the right carotid bifurcation. (
  • It was in close proximity to right common carotid artery beginning at the level of carotid bifurcation. (
  • Carotid body tumor is a rare neoplasm located at the bifurcation of the carotid artery. (
  • Are carotid body tumors benign? (
  • Most carotid body tumors are benign (not cancer ). (
  • However, most of the time these are benign, sporadic tumors. (
  • Regardless of the histologic appearance, the tumor is considered benign if it has not invaded the capsule and no metastases are found, although exceptions occur. (
  • Various imaging studies can be used to confirm the diagnosis of carotid body tumor (CBT), starting with simple ultrasonography with color Doppler, which can assess the vascularity of the neck mass and can sometimes reveal a possibility of a carotid body tumor (CBT), although it is not the best imaging modality to detect these tumors. (
  • Carotid body tumors are often painless, but your healthcare provider may want to remove the tumor because it can become large and affect the blood vessels in your neck or cause other symptoms. (
  • A carotid body tumor is suspected if a pulsatile mass in the neck is observed. (
  • Various imaging studies can be used to confirm the diagnosis of carotid body tumor (CBT), starting with simple ultrasonography with color Doppler. (
  • Being diagnosed with a pituitary tumor or pituitary disorder probably set many questions racing through your mind. (
  • This experience means that our doctors and nurses have seen nearly every kind of pituitary tumor and disorder imaginable. (
  • Not only is Barrow a place to receive the most advanced treatment and care for your pituitary tumor or disorder, we are also a place where you can help contribute to the scientific understanding and therapeutic research surrounding acromegaly, adenomas, gigantism, and other disorders that implicate the pituitary gland. (
  • Healthcare providers often use surgery and embolization to treat carotid body tumors. (
  • Transcatheter embolization to stop blood flow to the tumor, which you may have before surgery to help shrink the tumor. (
  • This procedure is an effective and promising method of preoperative embolization of carotid-body tumors and warrants further experience and study. (
  • In this article, we also review the literature on carotid-body tumor embolization and ethanol embolization. (
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor derived from chromaffin cells. (
  • The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers to the color the tumor cells acquire when stained with chromium salts. (
  • A pheochromocytoma is a catecholamine-secreting tumor of chromaffin cells typically located in the adrenals. (
  • Pritchett, J.W.: Familial Concurrence of Carotid Body Tumor and Pheochromocytoma. (
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor that may precipitate life-threatening hypertension. (
  • The Enigma of Carotid and Aortic Body Tumors. (
  • Although pheochromocytomas have classically been associated with 3 syndromes-von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1)-there are now 10 genes that have been identified as sites of mutations leading to these tumors. (
  • Common locations for extra-adrenal pheochromocytomas include the organ of Zuckerkandl (close to the origin of the inferior mesenteric artery), bladder wall, heart, mediastinum, and carotid and glomus jugulare bodies. (
  • Familial pheochromocytomas and carotid body tumors may be due to mutations in genes encoding the enzyme succinate dehydrogenase or other signaling molecules. (
  • Although the occurrence of neoplasms in ectopic adrenal nodules is far from common, pheochromocytomas, Leydig cell tumors and adrenal adenomas have been reported. (
  • The study found long-term successful control of the tumor growthi and mprovement of tinnitus and overall neurological status, as well as cranial nerve function. (
  • Strictly speaking, tinnitus is not a disease, but a human phenomenon, and some tinnitus is a warning sign of impending or existing problems in the body. (
  • To put it simply, it is a sudden tinnitus that lasts for a long time, which may be due to a problem in a certain part of the body. (
  • Some may also develop tinnitus after a tumor grows on the nerve, which is often diagnosed as neurological tinnitus clinically. (
  • For example, otitis media, otosclerosis, foreign body in the external auditory canal, hearing loss, etc., if it is a sudden long-term tinnitus, it may be related to the above diseases. (
  • Tinnitus in carotid body tumors is unilateral. (
  • Tinnitus suggests that there is a disease in the body. (
  • 2022). The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex. (
  • Are there complications of carotid body tumor treatment? (
  • Many people who have treatment for a carotid body tumor don't have complications. (
  • Fine needle aspiration biopsy (FNAB) is seldom requested for this purpose due to rare but dreadful reported complications such as hemorrhage and damage to the carotid artery. (
  • Carotid body tumors (CBTs) are treated with either surgery or radiotherapy. (
  • Descriptions of surgery for carotid body tumors have existed for over 100 years. (
  • Surgery to remove the tumor. (
  • Recovery time after surgery for a carotid body tumor is typically three to four weeks. (
  • If you have surgery to remove a carotid body tumor, you typically don't need further treatment. (
  • Surgery is the treatment of choice for glomus jugulare tumors. (
  • However, radiation therapy, particularly stereotactic radiosurgery (eg, Gamma Knife surgery), has been shown to provide good tumor growth control with a low risk of treatment-related cranial nerve injury. (
  • Of 22 patients with glomus jugulare tumors who underwent Gamma Knife surgery, neurologic status improved in 12 patients, 7 showed stable clinical condition, and 3 patients developed new moderate deficits. (
  • In this report of 20 patients with 24 carotid body tumors which is the largest series reported so far from Iran, we have evaluated the various characteristics of this relatively rare tumor in our population and compared our results with that of the literature. (
  • Dall′Igna, C., Antunes, M.B. and Dall′Igna, D.P. (2005) Radiation Therapy for Glomus Tumors of the Temporal Bone. (
  • Current surgical management of carotid body tumors[J]. J Vasc Surg, 2016, 64: 1703-1710. (
  • A Systematic Review and Meta-Analysis of the Presentation and Surgical Management of Patients With Carotid Body Tumours[J]. Eur J Vasc Endovasc Surg, 2019, 57: 477-486. (
  • A retrospective study by Davila et al suggested that carotid body tumors also tend to appear at a younger age in patients with succinate dehydrogenase mutations (see Pathophysiology). (
  • With regard to laboratory studies, check urinary catecholamines in patients who have any symptoms of a functional carotid body tumor (CBT). (
  • What are the symptoms of a carotid body tumor? (
  • A carotid body tumor may not cause any symptoms, but as the mass grows, it may press on nearby nerves and blood vessels. (
  • If your provider recommends observing the tumor (watchful waiting), let them know right away if you develop new symptoms. (
  • Therefore routine examination is not justifiable when symptoms relative to tumor presence are not present. (
  • Note that examining tumor tissue under a microscope cannot with certainty determine whether a tumor is cancerous. (
  • A study from Vanderbilt University found that in the absence of brainstem compression or concern for malignancy, observation of glomus jugulare tumors can be a viable initial management approach for elderly patients. (
  • Multidisciplinary management of carotid body tumors: a single-institution case series of 22 patients. (
  • The sporadic form is the most common type, representing approximately 85% of carotid body tumors (CBTs). (
  • The carotid body, which originates in the neural crest, is important in the body's acute adaptation to fluctuating concentrations of oxygen, carbon dioxide, and pH. (
  • Histologic evaluation revealed that the tumor contained diffuse ethanol-induced microemboli. (
  • Alpha-blockers and beta-blockers are useful for tumors secreting catecholamines. (
  • however, carotid body tumors (CBTs) are considered to be a disease of middle age. (
  • In this way the examination of the family members of patients, specially young ones, diagnosed with multicentric tumors may lead to negative results which doesn't meant that the disease can be developed at a later time period. (