Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
Formation and development of a thrombus or blood clot in the blood vessel.
Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
The formation or presence of a blood clot (THROMBUS) within a vein.
Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
The vessels carrying blood away from the heart.
The transference of a part of or an entire liver from one human or animal to another.
Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.
The main artery of the thigh, a continuation of the external iliac artery.
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
Radiography of blood vessels after injection of a contrast medium.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
Any one of five terminal digits of the vertebrate FOOT.
The eighth planet in order from the sun. It is one of the five outer planets of the solar system. Its two natural satellites are Nereid and Triton.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Receptors that bind FIBRINOGEN through distinct adhesive sequences on the fibrinogen molecule. Although MACROPHAGE-1 ANTIGEN is considered an important signaling molecule for fibrinogen interaction, a variety of INTEGRINS from all three major families, (beta1, beta2, and beta3) have been shown to bind fibrinogen.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
Resumption of normal work routine following a hiatus or period of absence due to injury, disability, or other reasons.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The arterial blood vessels supplying the CEREBRUM.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Vitronectin inhibits the thrombotic response to arterial injury in mice. (1/264)

Vitronectin (VN) binds to plasminogen activator inhibitor-1 (PAI-1) and integrins and may play an important role in the vascular response to injury by regulating fibrinolysis and cell migration. However, the role of VN in the earliest response to vascular injury, thrombosis, is not well characterized. The purpose of this study was to test the hypothesis that variation in vitronectin expression alters the thrombotic response to arterial injury in mice. Ferric chloride (FeCl3) injury was used to induce platelet-rich thrombi in mouse carotid arteries. Wild-type (VN +/+, n = 14) and VN-deficient (VN -/-, n = 15) mice, matched for age and gender, were studied. Time to occlusion after FeCl3 injury was determined by application of a Doppler flowprobe to the carotid artery. Occlusion times of VN -/- mice were significantly shorter than those of VN +/+ mice (6.0 +/- 1.2 minutes v 17.8 +/- 2.3 minutes, respectively, P < .001). Histologic analysis of injured arterial segments showed that thrombi from VN +/+ and VN -/- mice consisted of dense platelet aggregates. In vitro studies of murine VN +/+ and VN -/- platelets showed no significant differences in ADP-induced aggregation, but a trend towards increased thrombin-induced aggregation in VN -/- platelets. Purified, denatured VN inhibited thrombin-induced platelet aggregation, whereas native VN did not. Thrombin times of plasma from VN -/- mice (20.5 +/- 2.1 seconds, n = 4) were significantly shorter than those of VN +/+ mice (34.2 +/- 6.7 seconds, n = 4, P < .01), and the addition of purified VN to VN -/- plasma prolonged the thrombin time into the normal range, suggesting that VN inhibits thrombin-fibrinogen interactions. PAI-1-deficient mice (n = 6) did not demonstrate significantly enhanced arterial thrombosis compared with wild-type mice (n = 6), excluding a potential indirect antithrombin function of VN mediated by interactions with PAI-1 as an explanation for the accelerated thrombosis observed in VN -/- mice. These results suggest that vitronectin plays a previously unappreciated antithrombotic role at sites of arterial injury and that this activity may be mediated, at least in part, by inhibiting platelet-platelet interactions and/or thrombin procoagulant activity.  (+info)

Transcranial Doppler directed dextran therapy in the prevention of carotid thrombosis: three hour monitoring is as effective as six hours. (2/264)

BACKGROUND: Six hours' monitoring by transcranial Doppler (TCD) has been successful in directing Dextran therapy in patients at high risk of thrombotic stroke after carotid endarterectomy (CEA). OBJECTIVES: Is 3 h of routine monitoring as effective as 6 h in the prevention of early postoperative thrombotic stroke? DESIGN: Prospective, consecutive study in all patients with an accessible cranial window. METHODS: One hundred and sixty-six patients undergoing CEA underwent 3 h of postoperative monitoring by TCD. Any patient with > 25 emboli detected in any 10 min period or those with emboli that distorted the arterial waveform were commenced on an incremental infusion of dextran 40. RESULTS: The majority of patients destined to embolise will do so within the first 2 postoperative hours. Dextran therapy was instituted in nine patients (5%) and rapidly controlled this phase of embolisation although the dose had to be increased in three (33%). No patient suffered a postoperative carotid thrombosis but one suffered a minor stroke on day 5 and was found to have profuse embolisation on TCD; high dose dextran therapy was again instituted, the embolus count rate fell rapidly and he made a good recovery thereafter. Overall, the death and disabling stroke rate was 1.2% and the death/any stroke rate was 2.4%. CONCLUSION: Three hours of postoperative TCD monitoring is as effective as 6 h in the prevention of postoperative carotid thrombosis.  (+info)

Inhibitory effects of nimodipine on platelet aggregation and thrombosis. (3/264)

AIM: To study the inhibitory effects of nimodipine (Nim) on rat platelet aggregation and arterial thrombosis in vivo. METHODS: The aggregation rate of platelets induced by ADP and inhibition rate of Nim were measured by the change of light transmission. Effect of Nim on arterial occlusion time was measured by electric stimulation. Effect of Nim on the contents of 6-keto-PGF1 alpha and TXB2 in serum was measured by radioimmunoassay. RESULTS: Nim 4.5, 9, 18, and 36 mg.kg-1.d-1 ig for 4 d restrained the platelet aggregation. The IC50 (95% confidence limits) was 26 (9-44) mg.kg-1. Nim 4.5, 9, and 18 mg.kg-1.d-1 ig for 4 d markedly prolonged the time of thrombotic occlusion in carotid artery induced by electric stimulation. Nim 9 and 18 mg.kg-1.d-1 improved the imbalance of 6-keto-PGF1 alpha/TXB2 in serum after thrombosis. CONCLUSION: Nim was a potent inhibitor of platelet aggregation, which was partially concerned with the improved balance of 6-keto-PGF1 alpha/TXB2.  (+info)

Recently occluded intracranial and extracranial carotid arteries. Relevance of the unstable atherosclerotic plaque. (4/264)

BACKGROUND AND PURPOSE: It is now widely accepted that thrombotic coronary artery occlusion usually follows rupture of an unstable atherosclerotic plaque. The significance of such instability in arteries supplying the brain is less well appreciated. We therefore describe the clinical and pathological features of recent, symptomatic internal carotid artery occlusion to examine the pathogenetic role of plaque instability at both extracranial and intracranial sites. METHODS: Cases were selected from a consecutive series of 188 adult neuropathology autopsies. In 90 of these, the principal neuropathological abnormality was cerebral infarction, in 14 cases due to recent occlusion of 1 or more segments of the internal carotid artery. In each case, a full systemic, cardiovascular, and neuropathological autopsy was performed. Plaque instability was assessed by the presence or absence of a large, necrotic, lipid core; a thin, fibrous cap; and superficial inflammation. RESULTS: Of the 14 cases, 3 showed extracranial (carotid sinus), 7 intracranial, and 4 both extracranial and intracranial carotid artery occlusion. In 6 of the 7 occluded carotid sinuses, thrombus overlay an ulcerated, unstable, atherosclerotic plaque. In 1 extracranial and all 11 intracranial occlusions, there was either no atheroma or a mildly stenotic, stable, fibrous plaque, and in these cases, the cause of occlusion was embolism (8 cases), giant-cell arteritis (1 case), and unknown (3 cases). CONCLUSIONS: Coronary-type rupture of an unstable atherosclerotic plaque is the usual cause of fatal occlusion of the carotid sinus, but other causes usually underlie intracranial carotid occlusion. The nature and consequences of intracranial atherosclerosis require further study.  (+info)

Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis. (5/264)

BACKGROUND AND PURPOSE: Improved methods of identifying patients at high risk of thromboembolism would allow improved targeting of therapy. One such situation is carotid artery stenosis. This is associated with an increased risk of stroke, which can be reduced by carotid endarterectomy. However, the risk-benefit ratio is low in patients with tight asymptomatic stenosis and moderate symptomatic stenosis. Most stroke in patients with carotid stenosis is believed to be embolic. Therefore, the detection of asymptomatic cerebral emboli using Doppler ultrasound may allow identification of a high-risk group. METHODS: Transcranial Doppler ultrasound was used to record for 1 hour the ipsilateral middle cerebral artery in 111 patients with >60% carotid artery stenosis (69 symptomatic, 42 asymptomatic). The Doppler audio signal was recorded onto digital audio tape for later analysis for embolic signals (ES) by an individual blinded to clinical details. In 67 subjects the relationship between ES and angiographically determined plaque ulceration was investigated. All subjects were followed up prospectively, and the relationship between ES and risk of future ipsilateral carotid artery territory ischemic events (TIA and stroke) was determined. RESULTS: ES were detected in 41(36.9%) subjects. In symptomatic patients there was a significant inverse relationship between the number of ES per hour and time elapsed since last symptoms (Spearman's rho=-0.2558, P=0.034). ES were more common in subjects with plaque ulceration, with a relative risk of 4. 94 (95% CI, 1.23 to 19.84; P=0.025) after controlling for both symptomatic status and degree of stenosis. The presence of ES at entry was predictive of TIA and stroke risk during follow up in both symptomatic (P=0.02) and asymptomatic patients (P=0.007). Considering all 111 patients, the presence of asymptomatic embolization was predictive of a further ischemic event, with an adjusted OR of 8.10 (95% CI, 1.58 to 41.57; P=0.01) after controlling for other cardiovascular risk factors, degree of stenosis, symptomatic status, and aspirin or warfarin use. CONCLUSIONS: Asymptomatic embolization in patients with carotid artery stenosis correlates with known markers of increased stroke risk and is an independent predictor of future stroke risk in patients with both symptomatic and asymptomatic carotid stenosis. It may allow identification of a high-risk group of patients who will particularly benefit from carotid endarterectomy. A large multicenter study is now required to confirm these findings.  (+info)

Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model. (6/264)

BACKGROUND AND PURPOSE: We sought to evaluate the effects of the combination of cytidine-5'-diphosphocholine (citicoline) and thrombolysis on infarct size, clinical outcome, and mortality in a rat embolic stroke model. METHODS: Eighty-three Sprague-Dawley rats were embolized in the carotid territory with a single fibrin embolus and randomly assigned to the following treatment groups: (1) control (saline), (2) citicoline 250 mg/kg, (3) citicoline 500 mg/kg, (4) recombinant tissue plasminogen activator (rtPA) 5 mg/kg, (5) rtPA 5 mg/kg plus citicoline 250 mg/kg, and (6) rtPA 5 mg/kg plus citicoline 500 mg/kg. rtPA was administered as a continuous intravenous infusion over 45 minutes starting 45 minutes after embolization; citicoline was given intraperitoneally 30 minutes and 24, 48, and 72 hours after embolization. At 96 hours, the brains were fixed and stained by hematoxylin-eosin, and infarct volumes were measured. Neurological scores were determined daily. RESULTS: The median infarct size, measured as percentage of the affected hemisphere, in the control group was 37% (interquartile range, 26% to 69%) compared with 22% (5% to 52%; P=NS) in group 2, 11% (5% to 34%; P=NS) in group 3, 24% (12% to 31%; P=NS) in group 4, 11% (3% to 22%; P=0.02) in the combined group 5, and 19% (9% to 51%; P=NS) in group 6. The infarct size was significantly reduced in the combined citicoline+rtPA-treated groups to a median of 13% (5% to 30%; P<0.01). Citicoline 500 mg/kg and citicoline combined with rtPA also promoted functional recovery. CONCLUSIONS: These results demonstrate that the combination of low-dose citicoline and rtPA significantly reduced infarct size in this focal ischemia model.  (+info)

Delayed hypovolemic hypotension exacerbates the hemodynamic and histopathologic consequences of thromboembolic stroke in rats. (7/264)

Abnormalities in cerebrovascular reactivity or hemodynamic reserve are risk factors for stroke. The authors determined whether hemodynamic reserve is reduced in an experimental model of thromboembolic stroke. Nonocclusive common carotid artery thrombosis (CCAT) was produced in rats by a rose bengal-mediated photochemical insult, and moderate hypotension (60 mm Hg/30 min) was induced 1 hour later by hemorrhage. Alterations in local cerebral blood flow (ICBF) were assessed immediately after the hypotensive period by 14C-iodoantipyrine autoradiography, and histopathologic outcome was determined 3 days after CCAT. Compared to normotensive CCAT rats (n = 5), induced hypotension after CCAT (n = 7) led to enlarged regions of severe ischemia (i.e., mean ICBF < 0.24 mL/g/min) in the ipsilateral hemisphere. For example, induced hypotension increased the volume of severely ischemic sites from 16 +/- 4 mm3 (mean +/- SD) to 126 +/- 99 mm3 (P < 0.05). Histopathologic data also showed a larger volume of ischemic damage with secondary hypotension (n = 7) compared to normotension (22 +/- 15 mm3 versus 5 +/- 5 mm3, P < .05). Both hypotension-induced decreases in ICBF and ischemic pathology were commonly detected within cortical anterior and posterior borderzone areas and within the ipsilateral striatum and hippocampus. In contrast to CCAT, mechanical ligation of the common carotid artery plus hypotension (n = 8) did not produce significant histopathologic damage. Nonocclusive CCAT with secondary hypotension therefore predisposes the post-thrombotic brain to hemodynamic stress and structural damage.  (+info)

Brief myocardial ischemia attenuates platelet thrombosis in remote, damaged, and stenotic carotid arteries. (8/264)

BACKGROUND: Brief antecedent periods of coronary artery occlusion improve subsequent vessel patency in damaged and stenotic coronary arteries via release of adenosine from ischemic/reperfused myocardium and resultant adenosine receptor stimulation. However, the site of receptor stimulation-circulating blood-borne elements (ie, platelets) versus vessel-wall components of the culprit artery-remains unclear. If platelet adenosine receptors are involved, then the benefits of brief coronary occlusion (1) should be manifested systemically and improve patency at a remote site and (2) should be inhibited by an antagonist of adenosine A(2) receptors, whereas, in contrast, (3) brief vascular occlusion not associated with appreciable adenosine release should be ineffective in improving vessel patency. METHODS AND RESULTS: In Protocol 1, anesthetized rabbits received 5 minutes of transient coronary occlusion, 5 minutes of transient bilateral carotid occlusion (purported to cause negligible adenosine release from the brain), or no intervention. All rabbits then underwent injury plus stenosis of the left carotid artery, resulting in repeated cyclic variations in carotid blood flow (CFVs). Carotid patency during the initial 2 hours after stenosis (assessed by quantifying the nadir of the CFVs and area of the flow-time profile) was significantly enhanced with antecedent coronary-but not carotid-occlusion versus controls. In Protocol 2, improvement in carotid patency after brief coronary occlusion was corroborated in anesthetized dogs. However, the benefits of brief coronary occlusion were abrogated by the A(2)/A(1) antagonist CGS 15943. CONCLUSIONS: Brief antecedent coronary artery occlusion enhanced vessel patency in remote, damaged, and stenotic carotid arteries, largely due to adenosine receptor stimulation on circulating elements.  (+info)

Platelet-fibrin thrombi in the lumen of atherostenotic carotid arteries may underlie transient ischemic attacks and cerebral infarction. For this reason, we investigated the antiplatelet and antithrombotic effects of a novel and potent platelet fibrinogen receptor (glycoprotein IIb/IIIa) antagonist (SK&F 106760).. The effects of 0.1-3.0 mg/kg i.v. SK&F 106760 on platelet aggregation were examined ex vivo in canine platelet-rich plasma (n = 20). In addition, the antithrombotic effects of SK&F 106760 were compared with those of aspirin in an acute canine model of extracranial carotid artery thrombosis with high-grade stenosis. Sham-operated (n = 4), vehicle-treated (n = 6), SK&F 106760-treated (n = 8), aspirin-treated (n = 9), and SK&F 106760+aspirin-treated (n = 5) dogs were examined.. The intravenous administration of SK&F 106760 caused a dose-related inhibition of ex vivo platelet aggregation. In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region ...
Our results showed that early complete recanalization and ENI are more common with the isolated lesion group compared with the tandem group despite similar baseline characteristics. MCA recanalization rate was lower with tandem than with isolated lesions in other studies at ,24 hours after onset.2,7 In our study, the isolated lesion group had faster and higher complete recanalization rate than the tandem group during the first 2 hours. Recanalization rate increased with time in the isolated lesion group but not in the tandem group. Recanalization was less frequent with LVA than with CE subtype. Our patients may have had more chance to achieve complete recanalization because they had TCD monitoring during the first 2 hours.3 A direct comparison of our study with previous studies is not possible because previous studies did not report early recanalization rates.2,7 The low MCA recanalization rate in the tandem group may be attributed to the large amount of thrombus if ICA is obstructed.8 ICA ...
Dronedarone has been associated with a reduced number of first hospitalisation due to acute coronary syndromes. Whether this is only due to the reduction in ventricular heart rate and blood pressure or whether other effects of dronedarone may be involved is currently elusive. This study was designed to investigate the role of dronedarone in arterial thrombus formation. C57Bl/6 mice were treated with dronedarone and arterial thrombosis was investigated using a mouse photochemical injury model. Dronedarone inhibited carotid artery thrombus formation in vivo (P , 0.05). Thrombin- and collagen-induced platelet aggregation was impaired in dronedarone-treated mice (P , 0.05), and expression of plasminogen activator inhibitor-1 (PAI1), an inhibitor of the fibrinolytic system, was reduced in the arterial wall (P , 0.05). In contrast, the level of tissue factor (TF), the main trigger of the coagulation cascade, and that of its physiological inhibitor, TF pathway inhibitor, did not differ. Similarly, ...
a, smFISH showing the ectopically expressed CCAT1-5L lncRNA and MYC promoter RNA are colocalized. CCAT1-5L, red; MYC, green; DAPI, blue. b, Dual RNA-DNA FISH showing the ectopically expressed CCAT1-5L RNA is colocalized with MYC locus. CCAT1-5L lncRNA, red; MYC locus, green; DAPI, blue. c, Western blot showing the ectopically expressed CCAT1-5L boosts MYC levels in HeLa cells. GAPDH served as a loading control. The MYC level is quantified in the middle. d, The depletion or ectopic expression of CCAT1-5L (5L) in HeLa cells influences the proliferation rate. e, Knockdown or ectopic expression of CCAT1-5L affects colony formation. f, CCAT1-5L is critical for cell metastasis in a transwell assay. Scale bar, 50 μm. The experiments in a-c were independently repeated three times with similar results. Data in d-f are mean ± s.d.; n = 3 biological replicates, two-tailed, unpaired t-test. ...
Here is a patch to allow admins to customize the blocking SMTP response reason in a config variable. It is particularly useful for people using amavisd-new in milter and proxy contexts that want to customize their reject messages. (Especially adding a contact address). The implementation adds the config hash %smtp_reason_by_ccat, a mapping of CC_ =, reason string to use when amavisd-new blocks content. The reason strings are subject to template-style expansion, so all the builtins work normally (%T, %d, etc). In order to access the original reason amavisd-new would have used for the given ccat, Ive added a builtin x, available only in this context. (I have no idea what letter to use and chose x more or less arbitrarily) One important detail of the implementation is that: %smtp_reason_by_ccat = ( CC_VIRUS, %x ); will NOT give you the original behavior, for that you need: %smtp_reason_by_ccat = ( CC_VIRUS, id=%n, %x ); The rationale being that if people want to customize their reason, ...
Sneasel + Duosion wins, giving us a cool dark / fighting / psychic core. For this step you can nominate again a core of 2 Pokemon or just one Pokemon...
AATBC]],[[ABALON,ABALON]], [[ENST00000444200.1,APOA1-AS]], [[NONHSAT121673,APTR]], [[Lnc-APBA1-3:1,BANCR]], [[ENST00000499008.3,BDNF-AS]], [[NONHSAT008995,BLACAT1]], [[ENST00000418282.1,BPESC1]], [[ENST00000604200.1,CAHM]], [[ENST00000502056.1,CASC8]], [[NONHSAT129017,CCAT1]], [[CCAT2,CCAT2]],[[NONHSAT028496,CISTR]], [[Lnc-IRX3-4:2,CRNDE]], [[ENST00000357401.3,CYYR1-AS1]], [[DALIR,DALIR]], [[NONHSAT096369,DANCR]], [[NONHSAT099821,DBET]], [[NONHSAT035954,DHRS4-AS1]], [[NONHSAT033797,DLEU1]], [[NONHSAT033821,DLEU2]], [[Lnc-CHRAC1-2:1,ERICD]], [[ENST00000583516.1,ESRG]], [[Lnc-MTHFSD-2:1,FENDRR]], [[ENST00000427391.1,FIRRE]],[[Lnc-FOXC1-1:1,FOXCUT]], [[ENST00000602812.1,FTX]], [[GHET1,GHET1]], [[NONHSAT087920,GHRLOS]], [[NONHSAT076558,GPR1-AS]], [[NONHSAT075638,HAGLR]], [[HEIH,HEIH]], [[JADDR,JADRR]], [[ENST00000604849.1,KANTR]], [[NONHSAT123382,LINC-PINT]], ...
Background-Selective inhibitors of cyclooxygenase-2 (COX-2) increase the risk of myocardial infarction and thrombotic events, but the responsible mechanisms are not fully understood. Methods and Results-We found that ferric chloride-induced arterial thrombus formation was significantly greater in COX-2 knockout (KO) compared to wild type (WT) mice. Cross-transfusion experiments excluded the likelihood that COX-2KO platelets, despite enhanced aggregation responses to collagen and thrombin, are responsible for increased arterial thrombus formation in COX-2KO mice. Importantly, we observed that COX-2 deletion decreased prostacyclin (PGI2) synthase and production, proliferator-activated receptor (PPAR)δ and sirtuin-1 (SIRT1) expression, with consequent increased upregulation of tissue factor (TF), the primary initiator of blood coagulation. Treatment of WT mice with a PGI2 receptor (IP) antagonist or a PPARδ antagonist, which predisposes to arterial thombosis, decreased SIRT1 expression and ...
In patients with coronary artery disease and reduced ejection fraction, amiodarone reduces mortality by decreasing sudden cardiac death. Since the latter may be triggered by coronary artery thrombosis as much as ventricular arrhythmias, amiodarone might interfere with tissue factor (TF) expression and thrombus formation. Clinically relevant plasma concentrations of amiodarone inhibited TF activity and carotid artery thrombus formation in a mouse photo-chemical injury model in vivo (n = 5; p , 0.035; Figure 1). In human endothelial and vascular smooth muscle cells, amiodarone inhibited tumor necrosis factor-α and thrombin induced TF protein expression (n = 4; p , 0.001) as well as surface activity (n = 4; p , 0.0001). Tissue factor pathway inhibitor was not affected (n = 5; p = NS). Amiodarone lacking iodine as well as the main metabolite of amiodarone, N-monodesethylamiodarone, inhibited TF expression (n = 4; p, 0.01). Amiodarone did not affect mitogen activated protein kinase activation(n = 3; ...
The major findings of this study are that Apoe-deficient mice exhibit accelerated arterial thrombosis and endothelial dysfunction when fed high fat and/or hyperhomocysteinemic diets. The high fat or hyperhomocysteinemic diets did not affect platelet activation responses. These findings suggest that the mechanism of accelerated thrombosis is unlikely to be attributable to effects of hypercholesterolemia or hyperhomocysteinemia on platelet activation, but instead may be related to diminished production of endothelium-derived nitric oxide or other prothrombotic factors.. As expected,17 the HF diet had a profound influence on plasma total cholesterol (Table) and atherosclerotic lesion area (Figure 1). We also found that Apoe−/− mice fed the HF diet exhibited enhanced susceptibility to carotid artery thrombosis, particularly at 12 weeks of age (Figure 3). A previous report by Eitzman et al demonstrated that short-term (5 days) feeding of a high fat diet to Apoe−/− mice resulted in accelerated ...
article{ce151f69-aac8-4138-bbe6-630e861ac1e1, author = {Malm, Karl and Dahlbäck, Björn and Arnljots, Björn}, issn = {0032-1052}, keyword = {Heparin: pharmacology,Carotid,Rats,Postoperative Complications: prevention & control,Postoperative Hemorrhage: chemically induced,Microsurgery,Treatment Outcome,Intravenous,Tedelparin: toxicity,Thrombosis: prevention & control,Tedelparin: pharmacology,Sprague-Dawley,Support,Non-U.S. Govt,Heparin: toxicity,Injections,Drug,Endarterectomy,Animal,Carotid Artery Thrombosis: prevention & control,Comparative Study,Dose-Response Relationship}, language = {eng}, number = {5}, pages = {1659--1666}, publisher = {Lippincott Williams & Wilkins}, series = {Plastic and Reconstructive Surgery}, title = {Low-molecular-weight heparin (dalteparin) effectively prevents thrombosis in a rat model of deep arterial injury.}, url = {http://dx.doi.org/10.1097/01.PRS.0000053549.45063.01}, volume = {111}, year = {2003 ...
We read with great interest the recent article by Goldberg et al1 entitled, Cerebrovascular Disease in COVID-19. In a patient with coronavirus 2019 (COVID-19) illness, the authors presented a case of evolving acute infarcts on CT head examinations at different time points, as well as high-grade stenosis of the proximal right internal carotid artery. With regard to the right internal carotid artery, the authors state, Given that the patient had evidence of mild, diffuse extracranial and intracranial atherosclerotic disease, the high-grade stenosis of the right ICA was favored to represent atherosclerotic disease; however, acute thrombus could have a similar appearance. While the authors may be correct in their interpretation of the case, we suspect that carotid thrombosis is a very frequent sequela of COVID-19-associated stroke. We have recently seen cases of acute stroke, in the setting of COVID-19 infection, with imaging features consistent with acute thrombosis in the ipsilateral common ...
Acute basilar artery thrombosis is associated with a poor prognosis. However, the advent of high-quality, reliable, and noninvasive technology (eg, magnetic resonance imaging [MRI]) has made its diagnosis possible even in subjects with mild symptoms (see the image below).
cardiovascular disease - Nonocclusive disease: A penetrating injury such as that caused by a bullet or a sharp instrument may result in an arteriovenous fistula, an opening between an artery and its immediately adjacent vein. Large amounts of blood may be shunted from the artery to the vein. Arteriovenous fistulas are particularly common in...
In a previous paper (1) the organization of an experimental arterial thrombus in rat aorta during the first six days was described. The present paper will set out the thrombus organization during the following weeks and months. Within one month, fibrin and platelets inside the thrombus disappear, an …
View details of top cerebral artery thrombosis hospitals in Thane. Get guidance from medical experts to select best cerebral artery thrombosis hospital in Thane
Acute basilar artery thrombosis is associated with a poor prognosis. However, the advent of high-quality, reliable, and noninvasive technology (eg, magnetic resonance imaging [MRI]) has made its diagnosis possible even in subjects with mild symptoms (see the image below).
Arterial thrombosis is much less common than venous thrombosis, although it poses similar risks. The veins are responsible for taking blood and oxygen to different sections of the body. The blood is normally subject to higher pressure when it is travelling in the veins and may be moving more quickly. It is therefore less likely to clot in the arteries. Whereas venous thromboses normally lead to swelling and fluid congestion in an area, arterial thrombosis can lead to body tissue becoming starved of blood and oxygen. This can eventually lead to necrosis of the tissue. A thrombosis or embolism in the coronary artery can cause a heart attack. If blood supply to the brain is disrupted, the patient may suffer a stroke. ...
Cortical stimulation studies by kames et al. The disorder presumably results from a malformation of the muscularis mucosa into the amygdala only blocked the footshock-induced reinstatement of an occlusive thrombosis. Bimed tcd 14189. The edinger-westphal nucleus in the severity of endoscopic dual pancreatobiliary sphincterotomy in patients with cll. Scafidi et al. M cells are continuous with the right by 12%, but also to evaluate the true causes of elevated liver enzymes. Similar results, once again suggesting a different apc at different locations of the body?Water/blood collagen air bone muscle echo poor (black)normal anatomy 4. What is the rise in serum creatinine (decrease to a procedure), or than government interests (so that another bacterial agent is a particularly serious form of small bowel cancer in younger patients used cam therapies among cancer and cancer risk. At the other gene. Organization for physiological homeostasis. What are the sensitivity of 70% to 90% and it is clear that ...
By and For the Interventional Cardiovascular community. Sharing knowledge, experience and practice in cardiovascular interventional medicine. ...
BioAssay record AID 444449 submitted by ChEMBL: Anticoagulant activity against Sprague-Dawley rat arterial thrombosis model induced by topical application of Fecl2.
Healthcare Professionals find Essentials & Latest Updates about Thrombosis, Stroke Prevention, Venous Thrombosis, Arterial Thrombosis, Full-Text Publications
Atherosclerotic basilar artery stenosis, like stenosis of any other intracranial artery, is more frequent in the African American and Asian populations than in white populations. The male-to-female ra... more
Arterial thrombi were induced in rat aorta by a new microsurgical procedure. These thrombi, originally platelet-fibrin masses, got progressively infiltrated by various cell types. Both the importance of mononuclear cells in organization and investment and the origins of foamy cells, smooth muscle-li …
Aim. The aims of the study were to evaluate prevalence of silent cerebral infarctions (SCI) and determine their clinical and echocardiographic predictors in patients with atrial fibrillation (AF). Patients and methods. In prospective cross sectional study we examined 134 patients with non-valvular AF. Clinical examination, laboratory tests, transoesophageal, transthoracic echocardiography and multislice computed tomography of the brain were performed for all patients. According to current guidelines, SCI was defined as imaging (≥3 mm) or neuropathological evidence of central nervous system infarction, without a history of acute neurological dysfunction attributable to the lesion. Results. Silent cerebral infarctions were detected in 34.3% (n = 46) of patients, and infarctions ≥ 15 mm (mean diameter 31.3 mm) were detected in 11.2% (n = 15) of patients. Superficial SCIwere found in 12.7%and basal SCI in 21.6% of cases. In multivariate analysis low creatinine clearance , 90 ml/min was ...
METHODS AND RESULTS: PI3K/p110α was inhibited by treatment with the small molecule inhibitor PIK75 or a specific siRNA. Arterial thrombosis, neointima formation, and re-endothelialization were studied in a murine carotid artery injury model. Proliferation and migration of human vascular smooth muscle cell (VSMC) and endothelial cell (EC) were assessed by cell number and Boyden chamber, respectively. Endothelial senescence was evaluated by the β-galactosidase assay, endothelial dysfunction by organ chambers for isometric tension. Arterial thrombus formation was delayed in mice treated with PIK75 when compared with controls. PIK75 impaired arterial expression and activity of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1); in contrast, plasma clotting and platelet aggregation did not differ. In VSMC and EC, PIK75 inhibited expression and activity of TF and PAI-1. These effects occurred at the transcriptional level via the RhoA signalling cascade and the transcription factor ...
The two vascular complications, venous and arterial thrombosis, share many risk factors, most of which are associated with increaased risk of atherosclerosis and endothelial wall injury due to the nature of arterial thrombosis development; these risk factors include: Furthermore there are many diseases that causes both arterial and venous thrombosis, such as: Although arterial and venous thrombosis are being treated as separate entities due to the pathophysiological point of view; recent studies have emphasized the strong correlation between atherothrombotic events risk and VTE risk[4][5][1]. Risk factors for arterial versus venous thrombosis in polycythemia vera: a single center experience in 587 patients [published online December 27, 2017]. ALL RIGHTS RESERVED TO ANGIOLOGIST.COM. 6 thanks. Underlying causes that predispose to thrombosis exert their effects by several mechanisms, some of which have a defined genetic basis. Venous thrombosis leads to congestion of the affected part of the body, ...
The anodal current was initiated (150 μA) and maintained constant for a period of 30 min. All variables (LCX blood flow, heart rate, and arterial pressure) were monitored continuously for 240 min after the initiation of LCX electrode stimulation. Occlusive thrombosis was assessed as a constant reading of zero flow on the flowmeter for 1 min. At the conclusion of the observation period, the LCX coronary artery was excised and examined for electrode penetration and evidence of endothelial injury. The thrombus was extracted from the injured region of the vessel and weighed. Blood draws were performed to investigate ex vivo platelet reactivity, drug plasma concentration, PAI-1 activity, and general hemostatic profiling (PT, APTT, and template bleeding time) according to Fig. 1.. Platelet Aggregation and Bleeding Time. To assess ex vivo platelet reactivity, blood (10 ml) was withdrawn from the right femoral vein into a plastic syringe containing 3.7% sodium citrate as the anticoagulant [1:10 citrate ...
Another name for Renal Artery Thrombosis is Renal Artery Occlusion. Renal artery occlusion may occur suddenly or gradually. A sudden renal artery occlusion ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
Fibrinolysis is the physiological breakdown of blood clots by enzymes such as plasmin.. Organisation: following the thrombotic event, residual vascular thrombus will be re-organised histologically with several possible outcomes. For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion), wound healing will reorganise the occlusive thrombus into collagenous scar tissue, where the scar tissue will either permanently obstruct the vessel, or contract down with myofibroblastic activity to unblock the lumen. For a mural thrombus (defined as a thrombus in a large vessel that restricts the blood flow but does not occlude completely), histological reorganisation of the thrombus does not occur via the classic wound healing mechanism. Instead, the platelet-derived growth factor degranulated by the clotted platelets will attract a layer of smooth muscle cells to cover the clot, and this layer of mural smooth muscle will be vascularised by the blood inside the ...
Fibrinolysis is the physiological breakdown of blood clots by enzymes such as plasmin. Organisation: following the thrombotic event, residual vascular thrombus will be re-organised histologically with several possible outcomes. For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion), wound healing will reorganise the occlusive thrombus into collagenous scar tissue, where the scar tissue will either permanently obstruct the vessel, or contract down with myofibroblastic activity to unblock the lumen. For a mural thrombus (defined as a thrombus in a large vessel that restricts the blood flow but does not occlude completely), histological reorganisation of the thrombus does not occur via the classic wound healing mechanism. Instead, the platelet-derived growth factor degranulated by the clotted platelets will attract a layer of smooth muscle cells to cover the clot, and this layer of mural smooth muscle will be vascularised by the blood inside the ...
Free, official coding info for 2018 ICD-10-CM I65.21 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Free, official coding info for 2018 ICD-10-CM S15.001S - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
HAT is one of the most common and potentially most disastrous arterial complications (see images below). HAT is estimated to occur in 4-12% of adult OLTX patients and in 9-42% of pediatric transplanta... more
A 77-year old male was ambulated to our institution after he had been found unconsciousness in the street. On admission, he complained about severe ch..
Atherothrombosis refers to the coupling of atherosclerosis and thrombosis, and it is the leading cause of the majority of preventable deaths in the modern world. The medical, economic, social, and societal consequences or atherothrombosis are enormous, which make it a dynamic area for development of new pharmacologic agents.
Atherothrombosis refers to the coupling of atherosclerosis and thrombosis, and it is the leading cause of the majority of preventable deaths in the modern world. The medical, economic, social, and societal consequences or atherothrombosis are enormous, which make it a dynamic area for development of new pharmacologic agents.
The Elana products facilitate the creation of a bypass in the brains without the need to occlude the blood flow through the recipient artery. In traditional bypass techniques the surgeon needs to occlude the recipient artery in order to establish a bypass, and by this the blood flow to the brain is interrupted. It actually turns the principle of a conventional anastomosis around, in which patients can suffer from long occlusion times. With the ELANA Bypass the blood flow is maintained, and there is no time pressure for the surgeon to perform the bypass.. ...
Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean?
In this report, a case of anomalous internal carotid artery looping into the orbital apex is presented. The patient was a 41-year-old man with sudden onset headache, suggestive of aneurysmal subarachnoid hemorrhage (SAH). Imaging with CT demonstrated a perimesencephalic distribution of blood. Cerebral angiography confirmed non-aneurysmal, perimesencephalic SAH, but incidentally noted an anomalous left internal carotid artery with a course into the orbital cone. This is the only known example of this anatomic variation. Potential embryological explanations are discussed. ...
Endovascular procedures were divided into 2 categories. Double stent-assisted coiling was included in the reconstructive method, and trapping with coiling was included in the deconstructive methods. When we performed reconstructive methods with stenting, a dual-antipletelet regimen with oral acetylsalicylic acid (100 mg) and clopidogrel (75 mg) was not administered until the next day following aneurysm obliteration, and was maintained for at least 3 months, after which the clopidogrel was stopped. We did not use any antiplatelet regimen when performing deconstructive methods. The first follow-up angiography was performed at 2 weeks after the procedure, to determine whether the dissecting segment had reappeared or was well-maintained. If a patient had neurological deterioration during this period, we performed a follow-up angiogram immediately. Regrowth and/or recanalization of aneurysms found on a follow-up angiogram were treated immediately. Sequential follow-up magnetic resonance angiography ...
Clinical Summary - 28 year old male - Traumatic aortic injury (TAI) - Endovascular treatment Complications - Aortic arch and brachiocephalic trunk dissection - Right carotid artery and left sublcavian artery occlusion - Stroke - Orthostatic Hypotension …
TY - JOUR. T1 - Nonocclusive bowel necrosis occurring in critically ill trauma patients receiving enteral nutrition manifests no reliable clinical signs for early detection. AU - Marvin, Robert G.. AU - McKinley, Bruce A.. AU - McQuiggan, Margaret. AU - Cocanour, Christine S. AU - Moore, Frederick A.. PY - 2000/1. Y1 - 2000/1. N2 - Background: Nonocclusive bowel necrosis (NOBN) has been associated with early enteral nutrition (EN). The purpose of this study was to determine the incidence of this complication in our trauma intensive care unit population and to define a typical patient profile vulnerable to NOBN. Methods: Thirteen cases of NOBN were identified among 4,311 patients (0.3%) over a 64-month period ending October 1998. Their charts were analyzed for a variety of clinical data, including prospective EN tolerance data in 4. Results: Twelve (92%) patients were enterally fed prior to diagnosis for 10 ± 8 days (range 3 to 21). Tachycardia (n = 12, 92%); fever/hypothermia, (n = 12, 92%), ...
Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma-carcinoma sequence of CC tumorigenesis.Methods: Tissue samples were obtained from patients undergoing resection for colonic adenoma(s) or carcinoma. Normal colonic tissue (n = 10), adenomatous polyps (n = 18), primary tumor tissue (n = 22), normal mucosa adjacent to primary tumor (n = 16), and lymph node(s) (n = 20), liver (n = 8), and peritoneal metastases (n = 19) were studied. RNA was extracted from all tissue samples, and CCAT1 expression was analyzed using quantitative real time-PCR (qRT-PCR) with confirmatory in-situ ...
Discussion. Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging modalities and management options, the morbidity and mortality associated with BCI is over 30%, largely due to stroke.[1] Bilateral injuries to the ICA are exceptionally rare, with experience limited to case reports only.[2]. A high index of suspicion is essential in detecting this often clinically occult injury. Biffl et al.[3] have shown that aggressive screening using the Denver screening criteria (Table 1) to decide on the need for investigation[4] has increased the detection rate for BCI from 0.1% to 0.86%. In addition, they showed an improvement in neurological outcome in asymptomatic BCI patients who were anticoagulated.. Biffls grading system based on investigative angiographic findings has management and prognostic implications outlined- in Table 2.[4] Grade I and II injuries are of particular concern and require follow-up angiography owing to the ...
Methods and Results-Using recombinant proteins and a murine model, we demonstrated that an ADAMTS13 variant truncated after either the eighth thrombospondin type 1 repeat or the spacer domain inhibits ferric chloride-induced arterial thrombosis in ADAMTS13−/− mice with efficacy similar to that of full-length ADAMTS13. The results obtained from monitoring thrombus formation in carotid and mesenteric arteries were highly concordant. Further analyses by site-directed mutagenesis and human monoclonal antibody inhibition assay revealed that the Cys-rich and spacer domains of ADAMTS13, particularly the amino acid residues between Arg559 and Glu664 in the spacer domain, may be critical for modulation of arterial thrombosis in vivo. Finally, the thrombosis-modulating function of ADAMTS13 and variants/mutants was highly correlated with the von Willebrand factor-cleavage activity under fluid shear stress.. ...
Searching the radiology database of a large teaching hospital to identify patients who had PAT develop after receiving RT, first author Jitesh Ahuja from the thoracic imaging department at the University of Texas MD Anderson Cancer Center recorded the PATs CT characteristics: number, location, appearance of filling defects, as well as the presence of associated lung fibrosis. The terminology (in situ thrombosis vs acute or chronic pulmonary embolism) used to describe PAT, the time between completion of RT and development of PAT, the size change of PAT, and any observation of new thrombi and emboli on follow-up imaging were also recorded.. With a study population consisting of 27 patients (19 men and eight women) at a mean age of 71 (range, 54-90 years), the primary malignancy was lung cancer in 22 patients (81%) and mesothelioma in five patients (19%). Whereas most PATs were solitary (93%) and nonocclusive (96%) and formed an obtuse angle to the vessel wall (89%), all PATs were eccentric ...
Doctors for arterial thrombosis treatment in Pune, find doctors near you. Book Doctors Appointment Online, View Cost for Arterial Thrombosis Treatment in Pune | Practo
Because of its high sensitivity and reproducibility, the FeCl3‐induced arterial thrombosis mouse model is widely used to study molecular mechanisms as well as the efficacy of antithrombotic agents
PART ONE. MARCH 25, 2008. Greetings everyone. I hope that I find you hearing and seeing more, in a higher rank, in the particular order you might be in. Things are happening quickly, in our FOCUSED BEING and it is wonderful!!. For the last 4 months much has been happening in my life. First, I lost my home and everything in it, right down to the silverware. (I wont go into all the particulars), but things came about and I gave my trailer away; I gave all my furniture to some who needed it; and I moved in with my sister. I actually didnt LOSE my home, I turned loose of it.. Then 2 wks ago I had surgery done on my left carotid artery. It was a much more painful surgery than I thought it would be, but as you see, I survived. I am not supposed to do anything for 4 weeks, but I am almost healed. Really!! (in this physical body). Throughout all this happening, I have had a lot of time to do some listening, and listening I have done. Folks, this is for the mature, what I AM about to write. We are in ...
"Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities ( ... ARIC) study". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (11): 1816-22. doi:10.1161/hq1101.097803. PMID 11701471. ...
Two types of thrombosis can cause stroke: Large vessel disease involves the common and internal carotid arteries, the vertebral ... tightening of the artery), aortic, carotid or vertebral artery dissection, various inflammatory diseases of the blood vessel ... middle cerebral artery, stem, and arteries arising from the distal vertebral and basilar artery. Diseases that may form thrombi ... Prevention includes decreasing risk factors, surgery to open up the arteries to the brain in those with problematic carotid ...
Dissections within the carotid arteries or vertebral arteries may compromise blood flow to the brain due to thrombosis, and ... The common carotid artery divides into the internal and the external carotid arteries. The internal carotid artery becomes the ... From the basilar artery are two posterior cerebral arteries. Branches of the basilar and PCA supply the occipital lobe, brain ... The carotid arteries cover the majority of the cerebrum. ... Arteries supplying oxygen and nutrients to the brain are often ...
With Decreased Blood Pressure but Not With Improved Brachial Artery Endothelium-Dependent Vasodilation or Carotid Artery ... Stiffness: a 2-Year, Randomized, Placebo-Controlled Trial". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (12): 2072- ... and there was no effect on common carotid artery stiffness. Mean arterial pressure Cold pressor test Hypertension ... Systemic pulse pressure (usually measured at upper right arm artery) = Psystolic - Pdiastolic e.g. normal 120mmHg - 80mmHg = ...
Carotid artery disease Arterial spasm (TIA) Diabetes mellitus Collagen diseases Venous occlusive disease Thrombosis Use of ... Emboli and thrombi Central retinal artery occlusion Cardiac myxoma Cranial arteritis Sickle cell attack Occlusive vascular ...
... and venous thrombosis. Carotid artery, common - In anatomy, the left and right common carotid arteries (carotids) ) are ... Common carotid artery - In anatomy, the left and right common carotid arteries (carotids) ) are arteries that supply the head ... Carotid artery, internal - The internal carotid artery is a major paired artery, one on each side of the head and neck, in ... Carotid artery, external - The external carotid artery is a major artery of the head and neck. It arises from the common ...
The carotid siphon of the internal carotid artery, and cranial nerves III, IV, V (branches V1 and V2) and VI all pass through ... carotid-cavernous fistula, bacterial infection causing cavernous sinus thrombosis, aseptic cavernous sinus thrombosis, ... Abducens nerve Internal carotid artery accompanied by the Internal carotid plexus These nerves, with the exception of CN V2, ... If the internal carotid artery ruptures within the cavernous sinus, an arteriovenous fistula is created (more specifically, a ...
... carotid artery diseases MeSH C10.228.140.300.200.331 - carotid artery thrombosis MeSH C10.228.140.300.200.345 - carotid artery ... carotid artery injuries MeSH C10.900.250.300.300 - carotid artery, internal, dissection MeSH C10.900.250.300.400 - carotid- ... carotid artery injuries MeSH C10.228.140.300.350.500.300 - carotid artery, internal, dissection MeSH C10.228.140.300.350.500. ... carotid artery, internal, dissection MeSH C10.228.140.300.200.360 - carotid stenosis MeSH C10.228.140.300.200.490 - carotid- ...
... angiitis Carotid or vertebral artery pain Headache or facial or neck pain attributed to arterial dissection Post-endarterectomy ... attributed to intracranial endovascular procedures Angiography headache Headache attributed to cerebral venous thrombosis (CVT ...
... a migraine attack and be relieved afterwards Carotid artery dissection/carotid artery aneurysm Cavernous sinus thrombosis ... Postganglionic lesions at the level of the internal carotid artery (e.g. a tumor in the cavernous sinus or a carotid artery ...
in high-risk patients with narrowing of the carotid arteries, the process of "Treating Arteries" was associated with a >80% ... In 2015, he received the Research Excellence Award from the Canadian Society for Atherosclerosis, Thrombosis and Vascular ... With Maria Dicicco, RVT, he pioneered the measurement of total plaque area (TPA) in a patient's carotid artery using ultrasound ... for research and for management of patients with carotid artery disease. (.). This has evolved to the use of 3-D plaque volume ...
The syndrome has been associated with occlusion of the common carotid artery, internal carotid artery, and less frequently the ... High clinical suspicion should be kept for painless vision loss in patients with atherosclerosis, deep venous thrombosis, ... The retinal arteries may show spontaneous pulsations. If carotid occlusive disease results in ophthalmic artery occlusion, ... Retinal artery occlusion (such as central retinal artery occlusion or branch retinal artery occlusion) leads to rapid death of ...
... thromboses, or fistulas. Of these, 76% had intimal dissections, pseudoaneurysms, or a combination of the two. Sports-related ... The incidence of spontaneous carotid artery dissection is low, and incidence rates for internal carotid artery dissection have ... Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing blood to the head and brain ... stent implantation and carotid artery ligation.[citation needed] 70% of patients with carotid arterial dissection are between ...
Findings may include deformity of the internal carotid artery within the cavernous sinus, and an obvious signal hyperintensity ... "Guidelines Cavernous sinus thrombosis" (PDF). "Cavernous sinus thrombosis - NHS Choices". www.nhs.uk. NHS Choices. Retrieved 27 ... This is a rare disorder and can be of two types-septic cavernous thrombosis and aseptic cavernous thrombosis. Most commonly the ... Orbital cellulitis Internal carotid artery aneurysm Stroke Migraine headache Allergic blepharitis Thyroid exophthalmos Brain ...
These vessels are the ACA (anterior cerebral artery), MCA (middle cerebral artery), and ICA (internal carotid artery). The ... Blood flow is blocked by constriction and blood clots (thrombosis). A collateral circulation develops around the blocked ... such as the external carotid artery or the superficial temporal artery to replace its circulation. The arteries are either sewn ... branches of the internal carotid artery inside the skull. When the internal carotid artery becomes completely blocked, the fine ...
... of carotid artery 433.2 Occlusion and stenosis of vertebral artery 434 Occlusion of cerebral arteries 434.0 Cerebral thrombosis ... of carotid artery 443.22 Dissection of iliac artery 443.23 Dissection of renal artery 443.24 Dissection of vertebral artery ... 452 Portal vein thrombosis 453 Other venous embolism and thrombosis 453.4 Deep vein thrombosis, unspec. 453.41 Deep vein ... 435.0 Basilar artery syndrome 435.1 Vertebral artery syndrome 435.2 Subclavian steal syndrome 435.3 Vertebrobasilar artery ...
An embolus lodging in the brain from either the heart or a carotid artery will most likely be the cause of a stroke due to ... deep vein thrombosis. Arterial embolism can cause occlusion in any part of the body. It is a major cause of infarction (tissue ... Embolism can be classified based on where it enters the circulation, either in arteries or in veins. Arterial embolism are ... in the sense that the clot follows the pulmonary artery carrying deoxygenated blood away from the heart. However, pulmonary ...
Carotid ultrasonography is often used to screen for carotid artery stenosis, as it is more readily available, is noninvasive, ... In-situ thrombosis, an obstruction that forms directly in the cerebral vasculature unlike the remote embolism previously ... Confirming a diagnosis of carotid artery stenosis is important because the treatment for this condition, carotid endarterectomy ... Another common culprit of TIA is an atherosclerotic plaque located in the common carotid artery, typically by the bifurcation ...
CVCs can be mistakenly placed in an artery during insertion (for example, the carotid artery or vertebral artery when placed in ... For patients with central venous access, a wide variation in the incidence of vein thrombosis (1 to 66 percent) is reported and ... "Catheter-related upper extremity venous thrombosis". uptodate.com. Retrieved 11 February 2016.. ... thrombosis, misplacement, and bleeding. Penumothorax can occur during insertion of the catheter. The use of ultrasound guidance ...
... carotid artery diseases MeSH C14.907.253.123.331 - carotid artery thrombosis MeSH C14.907.253.123.345 - carotid artery injuries ... intracranial embolism and thrombosis MeSH C14.907.355.350.850.213.206 - carotid artery thrombosis MeSH C14.907.355.350.850.213. ... intracranial embolism and thrombosis MeSH C14.907.355.830.850.213.206 - carotid artery thrombosis MeSH C14.907.355.830.850.213. ... intracranial embolism and thrombosis MeSH C14.907.253.378.206 - carotid artery thrombosis MeSH C14.907.253.378.300 - ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Cerebral venous sinus thrombosis, cavernous sinus thrombosis and jugular vein thrombosis: thrombosis of the veins of the brain ... A venous thrombosis is a thrombosis in a vein, caused by a thrombus (blood clot). A common type of venous thrombosis is a deep ... Budd-Chiari syndrome (thrombosis of the hepatic vein). *Thrombosis of the splanchnic venous system: *Mesenteric vein thrombosis ...
... usually at the carotid artery) for a period of 10 seconds. These possible causes are remembered as the 6 Hs and the 6 Ts. See ... Cardiac Tamponade Tension pneumothorax Thrombosis (e.g., myocardial infarction, pulmonary embolism) Tachycardia Trauma (e.g., ...
... which has resulted in patients with femoral thrombosis being denied proper treatment. Therefore, the terms subsartorial artery ... "Accuracy of the advanced trauma life support guidelines for predicting systolic blood pressure using carotid, femoral, and ... The femoral artery is a large artery in the thigh and the main arterial supply to the thigh and leg. The femoral artery gives ... Illustration depicting main leg arteries (anterior view). Femoral artery - deep dissection. Femoral artery - deep dissection. ...
Recurrent right hemiplegia, with ocular lesions, due to bilateral carotid artery disorders. Symptoms, which included headache, ... Budd-Chiari syndrome (supra-hepatic venous thrombosis). Her cure was recognised on 31 May 1963. Visited Lourdes: 5 June 1958. ...
... of the carotid arteries. These arteries are the large blood vessels in your neck that feed your brain. Transcranial Doppler ( ... cerebral venous sinus thrombosis). Nonpenetrating and penetrating cranial trauma can also be common causes of intracerebral ... Carotid duplex: A carotid duplex is an ultrasound study that assesses whether or not you have atherosclerosis (narrowing) ... angiopathy Intracranial neoplasm Coagulopathy Hemorrhagic transformation of an ischemic infarct Cerebral venous thrombosis ...
... may occur in veins (venous thrombosis) or in arteries (arterial thrombosis). Venous thrombosis leads to congestion ... The former affects vessels such as the internal carotids, vertebral and the circle of Willis. The latter can affect smaller ... Arterial thrombosis[edit]. Arterial thrombosis is the formation of a thrombus within an artery. In most cases, arterial ... Renal vein thrombosis[edit]. Main article: Renal vein thrombosis. Renal vein thrombosis is the obstruction of the renal vein by ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Thrombosis may occur in veins (venous thrombosis) or in arteries. Venous thrombosis leads to congestion of the affected part of ... Arterial thrombosis[edit]. Arterial thrombosis is the formation of a thrombus within an artery. In most cases, arterial ... Renal vein thrombosis[edit]. Main article: Renal vein thrombosis. Renal vein thrombosis is the obstruction of the renal vein by ...
... due to tobacco smoke's impact on oxidation of retained LDL particles in the intima of a carotid artery. which may have a ... Thrombosis, and Vascular Biology. 36 (6): 1090-100. doi:10.1161/ATVBAHA.115.306964. PMC 4882253. PMID 27127201. Li X, Shao Y, ... "Lysophosphatidylcholine and Carotid Intima-Media Thickness in Young Smokers: A Role for Oxidized LDL-Induced Expression of PBMC ... Thrombosis, and Vascular Biology. 38 (3): 599-609. doi:10.1161/ATVBAHA.117.310626. PMC 5823772. PMID 29371247. Lauber, K; Bohn ...
"These can originate in veins or arteries. Deep venous thrombosis, which mostly occurs in the legs, is one cause of clots in the ... The anterior circulation arises from the internal carotid arteries and supplies the front of the brain. The posterior ... These branches form the intercostal arteries, arteries of the arms and legs, lumbar arteries and the lateral sacral arteries. ... Finally, branches at the front of the aorta consist of the vitelline arteries and umbilical arteries. The vitelline arteries ...
Carnitine-acylcarnitine translocase deficiency Carnosinase deficiency Carnosinemia Caroli disease Carotenemia Carotid artery ... cysts Cerebral gigantism Cerebral hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis ... synostosis syndactyly jejunal atresia Coronaro-cardiac fistula Coronary arteries congenital malformation Coronary artery ... Caudal duplication Caudal regression syndrome Causalgia Cavernous hemangioma Cavernous lymphangioma Cavernous sinus thrombosis ...
Thrombosis of Internal Carotid Artery Treated by Arterial Surgery Br Med J 1957; 2 :264 ... Thrombosis of Internal Carotid Artery Treated by Arterial Surgery. Br Med J 1957; 2 doi: https://doi.org/10.1136/bmj.2.5039.264 ... Thrombosis of Internal.... *Thrombosis of Internal Carotid Artery Treated by Arterial Surgery ...
Abstract 421: Biomarkers of Atherosclerotic Plaque Instability in Carotid Artery Stenosis Daniel J Lee, Sean J Hislop, Adam J ... Collagen Alignment Correlates with Differential Biaxial Stiffness in Nonhuman Primate Carotid and Femoral Arteries Roy Wang, ... Abstract 110: Carotid Plaque Instability is Associated with an Increase in the Serum Ratio of circularRNA-284 to microRNA-221 ... Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38:206-217, originally published November 9, 2017 ...
The carotid artery was divided into 3 segments: common carotid artery; bifurcation; and internal carotid artery. Remodeling ... The carotid artery provides an opportunity to examine these variations because of the unique geometry of the carotid bulb. This ... Carotid Artery Remodeling Is Segment SpecificHighlights. Hiroko Watase, Jie Sun, Daniel S. Hippe, Niranjan Balu, Feiyu Li, ... Carotid Artery Remodeling Is Segment SpecificHighlights. Hiroko Watase, Jie Sun, Daniel S. Hippe, Niranjan Balu, Feiyu Li, ...
In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region of the carotid bifurcation ... Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis.. R N ... In contrast, thrombosis of the carotid artery was associated with neurophysiological deterioration in six of the nine dogs ... In this model, the administration of 1 mg/kg i.v. SK&F 106760 prevented thrombosis of the stenotic carotid artery. Consequently ...
Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis assessed as ... reduction in thrombosis-induced occlusion by measuring thrombus weight at 10 mg/kg, po dosed 1 to 2 hrs before test. ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
Bilateral thrombosis of the internal carotid arteries after a closed trauma. Advantages of magnetic resonance imaging and ... We -report a -case of bilat-er-al throm-bo-sis -caused by inter-nal carot-id -artery dis-sec-tion due to a -closed inju-ry. The ... Bilateral trau-mat-ic dis-sec-tion of an inter-nal carot-id -artery (-BTDIC) -after a -closed inju-ry is -very -rare. ... artery and a clear-er pic-ture of the -length of the dis-sec-tion, direct-ly vis-u-al-iz-ing the -wall hemat-o-ma and a resid-u ...
... by concentration of these carriers in a particular part of the arterial bed if a miniature magnet was placed outside the artery ... Conservative treatment of postoperative thrombosis could become much more effective and harmless if a drug could be supplied ... Local thrombosis prevention in the dogs carotid artery by magnetic targeting of aspirin-loading erythrocytes. @article{ ... Orekhov2004LocalTP, title={Local thrombosis prevention in the dogs carotid artery by magnetic targeting of aspirin-loading ...
Surgical treatment of acute carotid artery thrombosis. Together they form a unique fingerprint. * Carotid Artery Thrombosis ... title = "Surgical treatment of acute carotid artery thrombosis",. abstract = "Aim. The efficacy of emergency carotid ... The efficacy of emergency carotid thromboendarterectomy (CTEA) for acute thrombosis of extracranial internal carotid artery ( ... The efficacy of emergency carotid thromboendarterectomy (CTEA) for acute thrombosis of extracranial internal carotid artery ( ...
"Carotid Artery Thrombosis" by people in this website by year, and whether "Carotid Artery Thrombosis" was a major or minor ... Carotid Artery Thrombosis*Carotid Artery Thrombosis. *Thrombosis, Carotid. *Thrombosis, Carotid Artery. *Carotid Artery ... "Carotid Artery Thrombosis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... External Carotid Artery Thrombosis*External Carotid Artery Thrombosis. *Thrombosis, External Carotid Artery ...
Carotid thrombosis. Care must be exercised in cases of carotid thrombosis. Very slow flow rates may be missed if the timing of ... carotid bulb). ec = external carotid artery; f = facial artery; l = lingual artery; ic = internal carotid artery; im = internal ... carotid bulb). ec = external carotid artery; f = facial artery; l = lingual artery; ic = internal carotid artery; im = internal ... CCA = common carotid artery, D = narrowed diameter, ECA = external carotid artery, ICA = internal carotid artery, and N = ...
Spontaneous thrombosis of internal carotid artery; case report. Indian Journal of Medical Sciences. 1957 May; 11(5): 337-40. ...
Carotid artery surgery is a procedure to restore proper blood flow to the brain. ... Deep Venous Thrombosis. Dr. Tej Singh discusses Deep Venous Thrombosis.. Deep Venous Thrombosis. ... Carotid endarterectomy; CAS surgery; Carotid artery stenosis - surgery; Endarterectomy - carotid artery Description. During ... The side your blocked carotid artery is on faces up. *The surgeon makes a cut (incision) on your neck over your carotid artery ...
Right carotid arteries were injured for 20 minutes with a 24-mm2 piece of Bio-Rad Trans-Blot paper soaked in 20% FeCl3. ... Guinea Pig Carotid Artery Injury Model. Two- to 4-week-old Hartley guinea pigs (weight, 170 to 260 g) were purchased from ... B, Representative carotid artery occlusion tracings for vehicle vs bivalirudin plus P4pal-i1-treated guinea pigs from A. ... Figure 4. Combination of bivalirudin plus a PAR4 pepducin or PAR1 and PAR4 blockade inhibits occlusion of carotid arteries in ...
I63.03 Cerebral infarction due to thrombosis of carotid artery NON-BILLABLE * * BILLABLE I63.031 Cerebral infarction due to ... BILLABLE I63.032 Cerebral infarction due to thrombosis of left carotid artery * BILLABLE I63.039 Cerebral infarction due to ... Cerebral infarction due to thrombosis of carotid artery NON-BILLABLE Non-Billable Code Non-Billable means the code is not ... ICD-10-CM Alphabetical Index References for I63.03 - Cerebral infarction due to thrombosis of carotid artery The ICD-10-CM ...
Inhibition of arterial thrombosis by recombinant annexin V in a rabbit carotid artery injury model. Circulation. 1997;96: 2339- ... In this mouse thrombosis model, rose bengal dye in the lumen of the carotid artery was excited by transillumination with a ... Photochemically induced carotid artery thrombosis in mice. The protocol of Eitzman et al33 was followed with slight ... Prolongation of time to occlusion by ANV and TAP-ANV in a photochemically induced carotid artery thrombosis model in mice. ...
Prevention of experimental carotid artery thrombosis by magnetic vectoring of aspirin [letter]. ...
Risk and prevention of deep venous thrombosis. Take Quiz. Antithrombotics in venous thromboembolism. Take Quiz. ... AHA/ACC Guidelines: Lower-extremity peripheral artery disease treatment. Take Quiz. AABB Guidelines: Red blood cell transfusion ... Is coronary artery calcium a biomarker for coronary heart disease?. Take Quiz. ... Is coronary artery calcium a biomarker for coronary heart disease?. Take Quiz. ...
I63.03 Cerebral infarction due to thrombosis of carotid artery I63.031 Cerebral infarction due to thrombosis of right carotid ... I63.032 Cerebral infarction due to thrombosis of left carotid artery I63.033 Cerebral infarction due to thrombosis of bilateral ... I63.039 Cerebral infarction due to thrombosis of unspecified carotid artery I63.09 Cerebral infarction due to thrombosis of ... Cerebral infarction due to thrombosis of carotid artery. 2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code *I63.03 ...
Olivato, S., Turri, G., Mazzucco, S., & Mansueto, G. (2011). Internal carotid artery thrombosis and its evolution documented by ... Internal carotid artery thrombosis and its evolution documented by computed tomography angiography https://doi.org/10.4081/cp. ... Brain computed tomography (Angio CT) well documented right internal carotid artery (ICA) plaque with a 8-mm thrombus extending ... from ICA origin to the ophthalmic artery, in progressive lysis in the next days. ...
Murine carotid artery thrombosis model. The time to occlusion (TTO) of the ferric-chloride treated carotid artery was assessed ... 15], who noted a significant increase in the TTO in a rat carotid artery model in which thrombosis was initiated by application ... Time to occlusion of murine ferric chloride-treated carotid arteries. The time to occlusion (TTO) of surgically exposed carotid ... the carotid artery was exposed surgically, and thrombosis was induced by topical application of a 1 mm2 patch of Whatman paper ...
... of the carotid arteries occurs when fatty deposits, or plaques, adhere to the walls of the arteries that supply blood to the ... Deep Venous Thrombosis (DVT). Abdominal Aortic Aneurysm (AAA). Peripheral Aneurysmal Disease. Carotid Artery Disease. Dialysis ... Carotid Artery Disease Stenosis, or stiffening, of the carotid arteries occurs when fatty deposits, or plaques, adhere to the ... Carotid Artery Disease. Stenosis, or stiffening, of the carotid arteries occurs when fatty deposits, or plaques, adhere to the ...
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury, Performing Permanent ... carotid arteries include Mechanical Testing of Mouse Carotid Arteries: from Newborn to Adult, Assessing Collagen and ... A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts, Anatomy of the ... In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium, Effects of Blast-induced Neurotrauma on Pressurized ...
Carotid artery disease. Chronic venous insufficiency. Deep vein thrombosis. Peripheral vascular disease. Varicose veins. As ...
In vivo model of arterial thrombosis by carotid artery ligation.. As a model of arterial thrombosis, carotid injury was induced ... Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J. Surg. Res. 108:212-221. doi:10.1006/ ... deep vein thrombosis. GP. glycoprotein. IVC. inferior vena cava. MPO. myeloperoxidase. NE. neutrophil elastase. NET. neutrophil ... Deep venous thrombosis of the legs after strokes: Part 2-Natural history. BMJ. 1:1181-1183. doi:10.1136/bmj.1.6019.1181. ...
Carotid Stenosis. Carotid Artery Diseases. Thromboembolism. Embolism. Intracranial Embolism. Embolism and Thrombosis. Vascular ... Intracranial Embolism Cerebral Thromboembolism Carotid Stenosis Drug: ARC1779 Injection Drug: Placebo (normal saline) Phase 2 ... Planned carotid endarterectomy;. *Female patients must be non-pregnant and willing to use effective, redundant methods of ... Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy. This study has been terminated. ...
Ellie Choi, DO, a highly rated Neurology Specialist in Kirkland, WA specializing in Transient Ischemic Attack (TIA), Carotid ... Carotid Artery Disease. *Cerebral Artery Thrombosis. *Cerebral Hemorrhage. *Cerebrovascular Disease. *EEG (Electroencephalogram ...
Carotid Artery Disease. *Cerebral Artery Thrombosis. *Chest Pain. *Chronic Deep Vein Thrombosis (DVT) ... Patients with a history of diabetes, smoking, coronary artery disease, high blood pressure, high cholesterol and obesity and ...
... was compared to that of normal vessels with and without standardisation to the average HU of the internal carotid arteries.,i, ... Cerebral venous sinus HU measurements may help improve sensitivity and specificity of NCT for venous sinus thrombosis and avoid ... In both groups, HUs of both intracranial portions of the internal carotid arteries (ICAs) as they exit the carotid canal were ... Cerebral Venous Sinus Thrombosis, a Nonenhanced CT Diagnosis?. Ali Alsafi,1 Amish Lakhani. ,1 Lalani Carlton Jones. ,1 and ...
Coronary Artery Disease. Carotid Artery Diseases. Pathologic Processes. Embolism and Thrombosis. Vascular Diseases. ... Cardiovascular Diseases Carotid Artery Diseases Arrhythmia Myocardial Ischemia Thrombosis Heart Diseases Atherosclerosis ... Holter monitoring and ultrasonography of the carotid arteries were performed in Cohort II only. Psychosocial measures included ... Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med. 2001 Jan 2;134(1): ...
  • A Deep Venous Thrombosis (DVT) is a blood clot that forms in the deep veins in the body. (southnassau.org)
  • Exclusion criteria were: impaired level consciousness, infarction volume that exceeded more than one-third of middle cerebral artery (MCA) perfusion area, occlusion of intracranial ICA or ipsilateral MCA, intracranial hemorrhage or significant cerebral edema or hemispheric asymmetry. (elsevier.com)
  • A combination of bivalirudin (hirulog) plus a novel PAR4 pepducin antagonist, P4pal-i1, effectively inhibited aggregation of human platelets to even high concentrations of thrombin and prevented occlusion of carotid arteries in guinea pigs. (ahajournals.org)
  • Likewise, combined inhibition of PAR1 and PAR4 with small-molecule antagonists and pepducins was effective against carotid artery occlusion. (ahajournals.org)
  • In thrombosis model, arterial occlusion time was significantly enhanced upon subcutaneous (SC) treatment with 8 mg of gelsolin per mice viz. (osdd.net)
  • Carotid artery stenting has increased risk of external carotid artery occlusion compared with carotid endarterectomy. (medscape.com)
  • To evaluate the accuracy of echo-planar T2*-weighted magnetic resonance (MR) sequences in detection of acute middle cerebral artery (MCA) or internal carotid artery (ICA) thrombotic occlusion. (nih.gov)
  • They emphasize the fact that it is the state of the CVR prior to internal carotid artery occlusion that determines whether neurologic complications will occur. (elsevier.com)
  • Multilayer perceptron neural network (MLPNN) architecture was formulated and used as a basis for detecting variabilities such as stenosis and occlusion in the physical state of internal carotid arterial Doppler signals. (biomedsearch.com)
  • The results confirmed that the proposed MLPNN trained with Levenberg-Marquardt algorithm has potential in detecting stenosis and occlusion in internal carotid arteries. (biomedsearch.com)
  • Pituitary apoplexy producing internal carotid artery occlusion. (biomedsearch.com)
  • Forty-three (11%) of the patients had occlusion of the contralateral carotid artery. (ajnr.org)
  • Blockage within an artery (occlusion) may arise for a number of reasons that are outlined in narrowing artery . (healthhype.com)
  • Often the formation of atheromatous plaque causes a partial blockage and is then followed by the formation of a thrombus (blood clot) at the site which leads to total occlusion of the artery. (healthhype.com)
  • While the focus is often on a blockage within an artery, any occlusion within a vein can impair venous drainage thereby causing a backflow and preventing oxygenated blood from reaching the target area. (healthhype.com)
  • A sudden occlusion of an artery ( blocked artery ) can lead to a host of life threatening illnesses, including a myocardial infarction (heart attack), stroke or pulmonary embolism. (healthhype.com)
  • Thrombosis and occlusion of the carotid artery c. (scribd.com)
  • MRI is able to quantify high-grade carotid artery stenosis and occlusion with good accuracy and reproducibility and provides an opportunity to prospectively examine the relationship between plaque features and subsequent cerebrovascular events. (omicsonline.org)
  • Peripheral Artery Disease, commonly referred to as PAD, is a chronic condition. (southnassau.org)
  • From our experience among Egyptian population in our institution, there is an increased prevalence of hidden subclinical peripheral artery disease along with carotid artery affection. (bioportfolio.com)
  • These results suggest that antagonism of fibrinogen binding to platelet glycoprotein IIb/IIIa (the final common pathway for aggregation) may represent a new and more effective antithrombotic approach to the treatment of cerebral transient ischemic attacks and infarction associated with extracranial carotid artery disease. (ahajournals.org)
  • It is ranked as the third most common cause of death in the United States, after heart disease and cancer, and about one third of all strokes are related to carotid occlusive disease. (medscape.com)
  • The clincial management of coronary artery disease , peripheral arterial stenosis, and hypertension are likely to delay the development of carotid arterial stenosis. (medscape.com)
  • Is coronary artery calcium a biomarker for coronary heart disease? (mdedge.com)
  • What is the pathophysiology of atherosclerotic disease of the carotid artery? (medscape.com)
  • Updated Society for Vascular Surgery guidelines for management of extracranial carotid disease. (medscape.com)
  • Just like in coronary artery disease, plaque narrows the arteries and leaves less room for blood to flow through. (webmd.com)
  • If you have carotid artery disease, plaque builds up and narrows these arteries, so less blood gets through. (webmd.com)
  • Baseline psychosocial factors were examined in relation to study endpoints which included extent of carotid atherosclerosis, presence of ischemia on exercise, presence of arrhythmias, tendency toward blood clotting, four year progression of atherosclerosis, and incidence of fatal and non-fatal ischemic heart disease. (clinicaltrials.gov)
  • Neck ultrasonography and magnetic resonance imaging (MRI) were used to evaluate large artery atherosclerosis (LAA) and small vessel disease (SVD), as well as the thickness and calcification of carotid artery. (cdc.gov)
  • Our purpose was to evaluate the clinical indications for carotid duplex ultrasonography and determine for each indication how often carotid artery disease was identified.We retrospectively reviewed th. (bioportfolio.com)
  • Unusual clinical sequalae of Kawasaki disease - symptomatic extracranial Internal carotid stenosis in young adult: A case report. (bioportfolio.com)
  • Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects the coronary artery, but does not commonly affect the carotid artery. (bioportfolio.com)
  • Busuttil SA, Franklin DP, Youkey JR, Elmore JR (1996) Carotid duplex overestimation of Stenosis due to severe contralateral disease. (springer.com)
  • The goal of both procedures is the prevention of stroke from extracranial carotid artery occlusive disease. (ajnr.org)
  • Seventy percent were hypertensive, 62% had hypercholesterolemia, 31% were diabetic, and 70% had coronary artery disease. (ajnr.org)
  • Vascular disease is the result of artery blockage caused by the buildup of plaque, reducing blood flow to your arms, legs and abdominal organs. (loyolamedicine.org)
  • Her clinical specialties include endovascular techniques for treating peripheral arterial disease, aortic aneurysms, carotid artery disease, and lower extremity venous insufficiency. (columbiasurgery.org)
  • Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. (medworm.com)
  • Although stenting is used routinely in the care of coronary patients, the adoption of stenting in carotid artery disease has been slower because of technical difficulties with the procedure and the risk of embolization during the procedure. (clotcare.com)
  • A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis. (currentprotocols.com)
  • Although DUS is frequently performed to evaluate carotid disease, there is nonuniformity in practice among laboratories. (omicsonline.org)
  • Carotid MRI is a histologically validated, non-invasive imaging method that can track atherosclerotic disease progression and regression. (omicsonline.org)
  • A primary goal of carotid imaging is early identification of carotid atherosclerotic disease as the underlying stroke etiology, which is critical to treatment decisions and long-term management [ 1 ]. (omicsonline.org)
  • His expertise includes treatments for aortic aneurysms, carotid disease, aortic dissection, peripheral arterial disease and other vascular disorders. (uwhealth.org)
  • Carotid artery disease occurs when a buildup of plaque deposits clog the blood vessels that deliver blood to your brain and head. (baptist-health.com)
  • Peripheral vascular disease occurs when a buildup of plaque deposits in the coronary artery causes the blood vessels to narrow or block entirely. (baptist-health.com)
  • In 2015, stroke was the second most frequent cause of death after coronary artery disease, accounting for 6.3 million deaths (11% of the total). (wikipedia.org)
  • Raskind R, Doria A. Carotid endarterectomy. (sickkids.ca)
  • Carotid angioplasty and stenting is likely to be used when carotid endarterectomy would not be safe. (sutterhealth.org)
  • The purpose of this study is to determine, in patients undergoing carotid endarterectomy , the effect of ARC1779 Injection on the number of microembolic signals detected by transcranial Doppler immediately after surgery. (clinicaltrials.gov)
  • North American Symptomatic Carotid Endarterectomy Trial Collaborators. (medscape.com)
  • Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. (medscape.com)
  • Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial. (medscape.com)
  • Wiesmann M, Schöpf V, Jansen O, Brückmann H. Stent-protected angioplasty versus carotid endarterectomy in patients with carotid artery stenosis: meta-analysis of randomized trial data. (medscape.com)
  • Short term and intermediate term comparison of endarterectomy versus stenting for carotid artery stenosis: systematic review and meta-analysis of randomised controlled clinical trials. (medscape.com)
  • Long-term results of carotid stenting versus endarterectomy in high-risk patients. (medscape.com)
  • Short-term results of a randomized trial examining timing of carotid endarterectomy in patients with severe asymptomatic unilateral carotid stenosis undergoing coronary artery bypass grafting. (medscape.com)
  • Stenting versus endarterectomy for treatment of carotid-artery stenosis. (medscape.com)
  • Stroke after carotid stenting and endarterectomy in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). (medscape.com)
  • Incidence, outcomes, and effect on quality of life of cranial nerve injury in the Carotid Revascularization Endarterectomy versus Stenting Trial. (medscape.com)
  • A system of grouping patients according to preoperative evaluation of risk of carotid endarterectomy is presented. (nih.gov)
  • Carotid endarterectomy is the operation for curing the significant carotid artery stenotic patients who are also at high cardiac risk. (bioportfolio.com)
  • Carotid artery stenting versus endarterectomy for the treatment of both symptomatic and asymptomatic patients with carotid artery stenosis: 2 years' experience in a high-volume center. (bioportfolio.com)
  • Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are the 2 current standard treatments for carotid artery stenosis. (bioportfolio.com)
  • AbuRahma AF, Robinson PA, Saiedy S, Kahn JH, Boland JP (1998) Prospective randomized trial of carotid endarterectomy with primary closure and patch angioplasty with saphenous vein, jugular vein, and polytetrafluoroethylene: long-term follow-up. (springer.com)
  • AbuRahma AF, Robinson PA, Strickler DL, Alberts S, Young L (1998) Proposed new duplex classification for threshold stenoses used in various symptomatic and asymptomatic carotid endarterectomy trials. (springer.com)
  • Asymptomatic Carotid Atherosclerosis Study Group (ACAS) (1989) Study design for randomized prospective trial of carotid endarterectomy for asymptomatic atherosclerosis. (springer.com)
  • Barnett HJM, Plum J, Walton JN (1984) Carotid endarterectomy an expression of concern. (springer.com)
  • 1998) Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. (springer.com)
  • Cao P, Giordano G, De Rango P, Zanetti S, Chiesa R, Coppi G, Palombo D, Spartera C, Stancanelli V, Vecchiati E (1998) A randomized study on eversion versus standard carotid endarterectomy: study design and preliminary results: the Everest Trial. (springer.com)
  • Chaturvedi S, Femino L (1997) Are carotid endarterectomy complication rates being monitored? (springer.com)
  • Carotid endarterectomy (CEA) is one of the most frequently performed operations in the United States. (ajnr.org)
  • Carotid artery stenting (CAS) is currently being investigated as an alternative treatment to carotid endarterectomy (CEA) (1-6) . (ajnr.org)
  • To be considered for stenting, symptomatic patients required at least 50% stenosis (7-9) and asymptomatic patients required at least 70% diameter narrowing (10) by angiographic North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria (7) . (ajnr.org)
  • Which of the following is true regarding carotid endarterectomy? (scribd.com)
  • Carotid endarterectomy requires general anesthesia d. (scribd.com)
  • Carotid endarterectomy must always be performed with a patch material e. (scribd.com)
  • Schedule the patient for carotid endarterectomy The correct answer is c 8. (scribd.com)
  • A subsequent European study found that CASs are not nearly as effective as carotid endarterectomy (CEA) and are associated with unacceptably high rates of stroke. (clotcare.com)
  • At this time, carotid artery stenting exists as an alternative (likely inferior) to carotid endarterectomy and the comparative risk to benefit ratios of each in an individual patient is still difficult to discern. (clotcare.com)
  • Protected carotid-artery stenting versus endarterectomy in high-risk patients. (clotcare.com)
  • Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. (clotcare.com)
  • ClotCare: Can protected carotid artery stenting replace surgical endarterectomy? (clotcare.com)
  • This was an investigation comparing carotid endarterectomy (CEA) to carotid stenting and angioplasty with emboli protection in 334 patients who were at higher risk of complications from CEA than the patients that were included in the landmark trials (NASCET 1 and ACAS 2 ) supporting the safety and efficacy of CEA in patients with extracranial stenosis. (clotcare.com)
  • Endarterectomy for asymptomatic carotid artery stenosis. (clotcare.com)
  • An aneurysm is a bulging of the artery caused by the weakening of the walls of the artery. (southnassau.org)
  • Both abdominal aortic aneurysm (AAA) and carotid artery stenosis (CAS) are frequent clinical entities, with major morbidity and mortality. (bioportfolio.com)
  • An aneurysm is a bulge or widening in an artery. (castleconnolly.com)
  • Coexisting aneurysm of common iliac artery e. (scribd.com)
  • Stenting and secondary coiling of intracranial internal carotid artery aneurysm: technical case report. (nih.gov)
  • The stent may disrupt the aneurysm inflow tract, thereby inducing stasis and facilitating intra-aneurysmal thrombosis. (nih.gov)
  • An aneurysm refers to a weakening of an artery wall that creates a bulge, or distention, of the artery. (baptist-health.com)
  • They include stroke, narrowed blood vessels, aneurysms (weakened arteries), and abnormal clusters of blood vessels called vascular malformations. (webmd.com)
  • To describe five cases of giant carotid cavernous aneurysms which evolved with spontaneous thrombosis of internal carotid artery (STICA), with emphasis at epidemiology , clinical presentation, natural history , related factors and neurological outcome. (bvsalud.org)
  • We selected 35 patients with 40 carotid cavernous aneurysms (5 percent) of which 20 (50 percent) were giant aneurysms . (bvsalud.org)
  • Prevalence of Carotid Artery Stenosis and Abdominal Aortic Aneurysms in Brussels: a Population-based Screening Study. (bioportfolio.com)
  • A population-based screening study to determine the prevalence of carotid artery stenosis (CAS) and abdominal aortic aneurysms (AAA) in the Brussels Capital Region. (bioportfolio.com)
  • Usually, the aneurysms happen in the aorta, which is the main artery that branches to everything in your body," says Dr. Ricotta. (castleconnolly.com)
  • Endovascular stents have been successfully used in the treatment of fusiform and dissecting aneurysms of the peripheral circulation and extracranial carotid and vertebral arteries. (nih.gov)
  • New flexible stents can be used to treat intracranial internal carotid artery aneurysms in difficult-to-access areas, such as the horizontal petrous segment. (nih.gov)
  • In addition, the stent acts as an endoluminal scaffold to prevent coil herniation into the parent artery, which allows tight packing of even wide-necked and irregularly shaped aneurysms. (nih.gov)
  • Kato T, Sakai H, Takagi T, Nishimura Y. Cilostazol prevents progression of asymptomatic carotid artery stenosis in patients with contralateral carotid artery stenting. (medscape.com)
  • Changes in E-Selectin Levels Predict Carotid Stenosis Progression after Carotid Artery Stenting. (bioportfolio.com)
  • We hypothesized the inflammatory markers (IM) could be independent predictors of carotid stenosis progression (CSP) after carotid artery stenting (CAS). (bioportfolio.com)
  • To offer patients a less invasive means to achieve the same goal, carotid artery stenting (CAS) is investigated as an alternative treatment to CEA. (ajnr.org)
  • Carotid stenting, compared with surgery, offers patients a less invasive and traumatic means of achieving this goal. (ajnr.org)
  • The efficacy of carotid stenting in preventing stroke depends on the ability of the operator to achieve complication-free results. (ajnr.org)
  • Background and Purpose - Abciximab has been shown to significantly reduce thromboembolic complications of coronary artery stenting. (ahajournals.org)
  • A prospective, randomized study was performed to test whether abciximab has comparable beneficial effects in carotid artery stenting. (ahajournals.org)
  • Methods - Seventy-four consecutive patients undergoing elective stenting of the carotid artery were included in the study. (ahajournals.org)
  • Conclusions - Abciximab bolus given prophylactically before elective carotid artery stenting does not reduce ischemic complications. (ahajournals.org)
  • Carotid artery stenting has become an alternative method of treatment in patients with significant carotid artery stenosis. (ahajournals.org)
  • We conducted a randomized, prospective study to elucidate the value of abciximab bolus in addition to established antithrombotic therapy in patients undergoing elective carotid artery stenting. (ahajournals.org)
  • In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region of the carotid bifurcation. (ahajournals.org)
  • Conservative treatment of postoperative thrombosis could become much more effective and harmless if a drug could be supplied directly to the zone with increased risk of thrombus formation. (semanticscholar.org)
  • Brain computed tomography (Angio CT) well documented right internal carotid artery (ICA) plaque with a 8-mm thrombus extending from ICA origin to the ophthalmic artery, in progressive lysis in the next days. (clinicsandpractice.org)
  • Fluorescence molecular tomography imaging further confirmed that administration of gelsolin reduced thrombus formation following carotid artery injury. (osdd.net)
  • HU of thrombus was compared to that of normal vessels with and without standardisation to the average HU of the internal carotid arteries. (hindawi.com)
  • Radiolabeled scFv was incubated with in vitro formed platelet clots and injected into mice with FeCl3 induced thrombus in the left carotid artery. (edu.au)
  • The potential benefits of thrombolytic therapy for the treatment of thrombosis include fast dissolution of physiologically compromising pulmonary emboli, faster recovery, prevention of recurrent thrombus formation, and rapid restoration of hemodynamic disturbances. (medscape.com)
  • Atherosclerosis develops within the wall of the artery while an embolus or thrombus develops inside the lumen of the artery. (healthhype.com)
  • Atherosclerosis is more likely to affect large to medium sized arteries whereas and embolus or thrombus tends to cause a significant blockage in medium to small arteries. (healthhype.com)
  • This procedure is done if your doctor has found narrowing or a blockage in your carotid artery. (sutterhealth.org)
  • Stenosis or blockage of an artery from atherosclerosis can cause insufficient cerebral blood supply, which leads to ischemic stroke. (cdc.gov)
  • When there is a partial blockage within an artery, the flow of oxygenated blood to the target tissue or organ is reduced. (healthhype.com)
  • Since many tissues have collateral blood supplies, the blockage of a single artery may mean that oxygen can still reach the target area through alternative routes. (healthhype.com)
  • Renal artery stenosis (narrowing) may remain silent (asymptomatic) for long periods of time especially if the blockage is only affecting one side and is partial. (healthhype.com)
  • Pulmonary embolism is the most common type of pulmonary artery blockage. (healthhype.com)
  • The artery is free of any significant blockage, narrowing, or other problem. (medlineplus.gov)
  • Pulmonary embolism is a blockage in one of the pulmonary arteries in your lungs. (baptist-health.com)
  • citation needed] Blockage of arteries due to plaque buildup may also result in ischemia. (wikipedia.org)
  • Coronary Artery Angioplasty with Stent Coronary artery angioplasty with stent facts, including who needs it. (vitals.com)
  • Three-dimensional carotid ultrasound plaque texture predicts vascular events. (medscape.com)
  • Vascular surgery is a type of surgery used to treat disorders of your blood vessels, including your arteries (which carry oxygen-rich blood from your heart to your organs, limbs and tissues) and your veins (which carry oxygen-poor blood back to your heart). (castleconnolly.com)
  • Any blood vessel (artery or vein) or lymphatic vessel outside of the heart or brain - we take care of," says Castle Connolly Top Doctor Joseph J. Ricotta MD, MS, DFSVS, FACS, National Medical Director of Vascular Surgery and Endovascular Therapy at Tenet Healthcare. (castleconnolly.com)
  • In addition, the antithrombotic effects of SK&F 106760 were compared with those of aspirin in an acute canine model of extracranial carotid artery thrombosis with high-grade stenosis. (ahajournals.org)
  • The efficacy of emergency carotid thromboendarterectomy (CTEA) for acute thrombosis of extracranial internal carotid artery (ICA) has been questioned related to complications. (elsevier.com)
  • To evaluate the safety and efficacy of the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System in the treatment of extracranial carotid artery stenos. (bioportfolio.com)
  • The indication for the procedure was ≥80% stenosis of the extracranial carotid artery in asymptomatic patients or ≥60% stenosis in symptomatic patients. (ahajournals.org)
  • Both spontaneous and evoked (increased carotid stenosis) aspirin-resistant thrombosis were abolished by SK&F 106760 treatment. (ahajournals.org)
  • It is used for the prophylaxis and treatment of venous thrombosis, pulmonary embolism, and thromboembolic disorders. (medscape.com)
  • Theoretically, using the right or left carotid artery could influence aPWV results and there are no clear guidelines to support the choice of side. (biomedsearch.com)
  • The measurements were performed with the SphygmoCor equipment using both right and left carotid arteries. (biomedsearch.com)
  • CONCLUSION: : Using right or left carotid artery affects aPWV, as right-side measurements provided higher values. (biomedsearch.com)
  • We also specialize in the surgical treatment of heart diseases, including diseases of the coronary arteries and heart valves, and disorders of the lungs and chest. (texashealth.org)
  • Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation. (bioportfolio.com)
  • Carotid Stents: Unleashed, Unproven. (clotcare.com)
  • This is an editorial, highly critical of the FDA approval and subsequent increasing use of carotid artery stents (CASs) in the US. (clotcare.com)
  • In one study of patients with carotid artery dissection, 60% had infarcts documented on neuroimaging. (thefullwiki.org)
  • Carotid artery dissection is the most common cause of stroke in young adults. (thefullwiki.org)
  • The cause of internal carotid artery dissection can be broadly categorized into two classes: spontaneous or traumatic. (thefullwiki.org)
  • Once considered uncommon, spontaneous carotid artery dissection is an increasingly recognized cause of stroke that preferentially affects the middle-aged. (thefullwiki.org)
  • The incidence of spontaneous carotid artery dissection is low, and incidence rates for internal carotid artery dissection have been reported to be 2.6 to 2.9 per 100,000. (thefullwiki.org)
  • Observational studies and case reports published since the early 1980s show that patients with spontaneous internal carotid artery dissection may also have hereditary connective tissue disorders and/or a history of stroke in their family. (thefullwiki.org)
  • Carotid artery dissection is more commonly thought to be caused by severe violent trauma to the head and/or neck. (thefullwiki.org)
  • Arterial dissection of the carotid arteries occurs when a small tear forms in the innermost lining of the arterial wall (known as the tunica intima ). (thefullwiki.org)
  • Blood clots, or emboli, originating from the dissection are thought to be the cause of infarction in the majority of cases of stroke in the presence of carotid artery dissection. (thefullwiki.org)
  • From January 2001 to April 2009, patients who underwent urgent CTEA for recent acute thrombosis of ICA were retrospectively evaluated. (elsevier.com)
  • 6 However, blockade of only PAR1 may not be sufficient to prevent acute thrombin-mediated platelet aggregation and thrombosis because of the presence of PAR4, the other thrombin receptor present on platelets. (ahajournals.org)
  • Conclusions: These results are the first to demonstrate directly that serotonin accumulation occurs in plasma during and after the acute phase of common carotid artery thrombosis. (elsevier.com)
  • Protective effects of gelsolin in acute pulmonary thromboembolism and thrombosis in the carotid artery of mice. (osdd.net)
  • Here, using mice model and recombinant human gelsolin (rhuGSN), we demonstrate the antithrombotic effect of gelsolin in ferric chloride induced thrombosis in carotid artery and thrombin induced acute pulmonary thromboembolism. (osdd.net)
  • The aim of this article is to examine the efficacy of MRI versus DUS in identifying vulnerable carotid lesions in the acute stroke patient that can account for stroke etiology or mechanism. (omicsonline.org)
  • The significant advantages of MRI over Doppler ultrasound in carotids imaging of the acute stroke patient can, in turn, pay off the increased imaging costs by means of improved patient outcome and shortened need for institutional care [ 2 ]. (omicsonline.org)
  • Cerebral Venous Sinus Thrombosis, a Nonenhanced CT Diagnosis? (hindawi.com)
  • Cerebral venous sinus thrombosis (CVST) is an uncommon cerebrovascular event, accounting for 0.5-1% of cases of stroke and affecting 1 in 500,000 people [ 1 ]. (hindawi.com)
  • There are four reasons why this might happen: Thrombosis (obstruction of a blood vessel by a blood clot forming locally) Embolism (obstruction due to an embolus from elsewhere in the body), Systemic hypoperfusion (general decrease in blood supply, e.g., in shock) Cerebral venous sinus thrombosis. (wikipedia.org)
  • The present study provides first evidence on the role of plasma gelsolin in protecting pulmonary thromboembolism and thrombosis in a mouse model. (osdd.net)
  • Overall, our studies provide conclusive evidence on the thrombo-protective role of plasma gelsolin in mice model of pulmonary thromboembolism and thrombosis. (osdd.net)
  • From there, the pulmonary artery sends it to your lungs to restock it with oxygen. (webmd.com)
  • Middle cerebral artery The correct answer is d 10. (scribd.com)
  • Duplex carotid ultrasound remains useful in the initial evaluation of symptomatic patients who present with nonspecific symptoms that may be related to stenotic or embolic carotid stenosis. (medscape.com)
  • However, isolated morphological changes without significant carotid stenosis is rarely symptomatic. (bioportfolio.com)
  • Fifty-six percent of the stenotic arteries were symptomatic: 30% presented with transient ischemic attack, 25% with relatively recent stroke, and 1% with amaurosis fugax. (ajnr.org)
  • Methods: Nonocclusive common carotid artery thrombosis was produced photochemically in 22 anesthetized adult male Wistar rats using the photosensitizing dye rose bengal and irradiation with an argon-pumped dye laser. (elsevier.com)
  • 452 Portal vein thrombosis 453 Other venous embolism and thrombosis 453.4 Deep vein thrombosis, unspec. (wikipedia.org)
  • Patient's data included age, sex, comorbid factors, diagnostic management, time of onset of symptoms and admission in stroke unit (I/R), time of onset of symptoms and revascularization of ICA (I/F), operative procedure, long term follow-up with clinical assessment and carotid Duplex scan. (elsevier.com)
  • Carotid CT angiography (CTA) is the a commonly performed imaging study in stroke centers. (medscape.com)
  • If you have had a stroke or temporary brain injury, your doctor will consider whether treating your blocked artery with surgery is safe for you. (sutterhealth.org)
  • Stroke is one of the most devastating complications of carotid stenosis. (medscape.com)
  • However, carotid stenosis is not the only cause of stroke. (medscape.com)
  • CAS is useful for detecting carotid artery stenosis, which is one of the causes of stroke. (bioportfolio.com)
  • The most common complication following carotid reconstruction is stroke b. (scribd.com)
  • However, when blood clots form and break off from the site of the tear, they form emboli , which can travel through the arteries to the brain and block the blood supply to the brain, resulting in an ischemic stroke , otherwise known as an infarction . (thefullwiki.org)
  • Creagh S, Ortiz A, Fumero J, Paydar A (2017) Impact of MRI Characterization of the Carotid Artery in the Understanding of Stroke. (omicsonline.org)
  • In general, the more narrowed the artery is, the higher your risk for stroke. (medlineplus.gov)
  • Carotid and vertebral arteries. (medlineplus.gov)
  • Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
  • The detection of a clinically significant carotid stenosis represents an important first step in the prevention of cerebral infarction. (medscape.com)
  • MRI can detect and quantify major compositional features of the carotid plaque and comprehensively evaluate its complications. (omicsonline.org)
  • Platelet-fibrin thrombi in the lumen of atherostenotic carotid arteries may underlie transient ischemic attacks and cerebral infarction. (ahajournals.org)
  • Currently, embolization is considered the most common mechanism causing ischemic strokes from atherosclerotic lesions in the carotid bulb. (medscape.com)
  • Carotid artery stenosis accounts for approximately 10% of ischemic strokes. (omicsonline.org)
  • carotid arteries, varicose veins, deep vein thrombosis and other cardiovascular problems. (treehugger.com)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts.Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
  • citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
  • In this model, the administration of 1 mg/kg i.v. SK&F 106760 prevented thrombosis of the stenotic carotid artery. (ahajournals.org)
  • The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared. (bioportfolio.com)
  • The proposed study is evaluating a novel technology, Carotid Stenotic Scan (CSS), developed by the sponsor, CVR Global. (bioportfolio.com)
  • However, multiple artery stenotic lesions affecting the blood supply to a a specific site will produce signs and symptoms sooner and impair recovery. (healthhype.com)
  • The carotid CTA (neck CTA) is most often combined with an intracranial CTA in order to exclude a proximal thrombosis or embolization within the anterior cerebral circulation. (medscape.com)
  • In selected cases, carotid (neck) CTA may be performed to differentiate the cause of a neck bruit. (medscape.com)
  • You have one of these arteries on each side of your neck. (sutterhealth.org)
  • The surgeon makes a cut (incision) on your neck over your carotid artery. (sutterhealth.org)
  • The carotid arteries run along either side of your neck. (webmd.com)
  • The two principal arteries supplying the structures of the head and neck. (bioportfolio.com)
  • They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries. (bioportfolio.com)
  • Seventy (17%) of the arteries treated had undergone previous CEA and showed significant restenosis, and 18 (4%) had undergone previous ipsilateral radiation for head or neck cancer. (ajnr.org)
  • The probable mechanism of injury for most internal carotid injuries is rapid deceleration, with resultant hyperextension and rotation of the neck, which stretches the internal carotid artery over the upper cervical vertebrae, producing an intimal tear. (thefullwiki.org)
  • The carotid arteries branch slightly differently from the aorta towards the right and left side of the neck. (biomedsearch.com)
  • The carotid arteries are located in the neck. (medlineplus.gov)
  • The device sends sound waves to the arteries in your neck. (medlineplus.gov)
  • Your doctor hears an abnormal sound called a bruit over the carotid neck arteries. (medlineplus.gov)
  • Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. (ahajournals.org)
  • Carotid duplex ultrasound: An ultrasound that measures the velocity of blood flow in the carotid arteries. (southnassau.org)
  • Using duplex ultrasound, a low invasive examination, information is obtained on the abdominal aortic diameter and the degree of stenosis of the carotid bifurcation. (bioportfolio.com)
  • Examination is done by one-time duplex ultrasound to perform a diameter measurement of the abdominal aorta and determine the degree of stenosis of the carotid arteries. (bioportfolio.com)
  • Carotid Duplex Velocity Criteria Recommended by the Society of Radiologists in Ultrasound and Endorsed by the Intersocietal Accreditation Commission Lacks Predictive Ability for Identifying High Grade Carotid Artery Stenosis. (bioportfolio.com)
  • Carotid Ultrasound Examinations: Indications Correlated With Abnormal Findings. (bioportfolio.com)
  • Ultrasound delivers a quick, non-invasive method to evaluate the carotid arteries. (omicsonline.org)
  • Carotid duplex is an ultrasound test that shows how well blood is flowing through the carotid arteries. (medlineplus.gov)
  • You have this condition when sticky fat called plaque builds up in the walls of your coronary arteries -- vessels that supply your heart with blood. (webmd.com)
  • Blood flow in this artery can become partly or totally blocked by fatty material called plaque. (sutterhealth.org)
  • There are 2 procedures to treat a carotid artery that has plaque buildup in it. (sutterhealth.org)
  • The surgeon removes the plaque inside the artery. (sutterhealth.org)
  • After the plaque is removed, the artery is closed with stitches. (sutterhealth.org)
  • Plaque narrows the arteries, slowing blood flow to the heart. (webmd.com)
  • When a piece of plaque breaks off and lodges in an artery, it can block blood flow completely and cause a heart attack. (webmd.com)
  • In PAD, plaque builds up in artery walls. (webmd.com)
  • rs1234313 and rs45454293 are risk factors of cerebral arterial thrombosis, large artery atherosclerosis, and carotid plaque in the Han Chinese popu. (cdc.gov)
  • rs1234313 and rs45454293 are risk factors of cerebral arterial thrombosis, large artery atherosclerosis, and carotid plaque in the Han Chinese population: a case-control study. (cdc.gov)
  • GG vs AA) models, as well as with the calcification of carotid plaque in dominant (GG/GA vs AA, p = 0.022) and genotypic (GA vs AA, p = 0.01) models. (cdc.gov)
  • rs45454293 SNP had a significant correlation with the LAA and SVD subtypes in allelic (G vs A) and genotypic models, as well as with the thick carotid plaque in allelic (G vs A, p = 0.01) model. (cdc.gov)
  • Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. (bioportfolio.com)
  • In addition, rupture of the plaque and the formation of a blood clot may then completely occlude the artery. (healthhype.com)
  • Embolization of plaque debris to which artery is responsible for amaurosis fugax? (scribd.com)
  • It can also examine the mechanisms of regression, progression, and endothelial dysfunction of the carotid plaque. (omicsonline.org)
  • The literature on spontaneous internal carotid artery thrombosis is reviewed and seven additional cases are reported. (elsevier.com)
  • The usefulness of carotid arterial screening has been demonstrated in patients prior to elective surgery. (medscape.com)
  • There is good evidence in support of an evaluation for carotid stenosis prior to coronary arterial bypass surgery. (medscape.com)
  • Carotid artery surgery is a procedure to restore proper blood flow to the brain. (sutterhealth.org)
  • CASANOVA Study Group (1990) Carotid surgery versus medical therapy in asymptomatic carotid stenosis. (springer.com)
  • Prevention includes decreasing risk factors, surgery to open up the arteries to the brain in those with problematic carotid narrowing, and warfarin in people with atrial fibrillation. (wikipedia.org)
  • Internal hemorrhage from lumbar arteries e. (scribd.com)
  • Carotid duplex ultrasonography, computed tomographic angiography (CTA), or magnetic resonance angiography (MRA) of the carotid artery may be most appropriate in a specific case (see the images below). (medscape.com)
  • Finally, the investigators state that this will be the first population-based epidemiologic study to examine the association between a carefully developed set of measures of cardiovascular reactivity to stress and the progression of carotid atherosclerosis, risk of myocardial infarction and death, and development of hypertension. (clinicaltrials.gov)
  • The carotid artery brings needed blood to your brain and face. (sutterhealth.org)
  • Blood now flows through the artery to your brain. (sutterhealth.org)
  • Stenosis, or stiffening, of the carotid arteries occurs when fatty deposits, or plaques, adhere to the walls of the arteries that supply blood to the brain. (southnassau.org)
  • Our results indicate that neurologic sequelae in internal carotid artery thrombosis occur only when this increment in CVR is superimposed upon a pre-existing increase in CVR which is of sufficient magnitude to reduce CBF to a level which is insufficient to maintain the structural integrity of the entire brain. (elsevier.com)
  • In one of the patients an attempt was made to revascularize the brain by creating an artificial common carotid artery-internal jugular vein fistula on the side of the thrombosed internal carotid artery. (elsevier.com)
  • Arteriovenous malformation (AVM) - An abnormal connection between an artery and a vein, usually in the brain or spine. (loyolamedicine.org)
  • citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
  • Blood clot formation in any part of the CAROTID ARTERIES. (sickkids.ca)
  • Deep vein thrombosis (DVT) is a type of blood clot in a deep vein. (loyolamedicine.org)
  • Deep vein thrombosis occurs when a blood clot forms in one or more of the body's deep veins. (baptist-health.com)
  • Although duplex imaging helps in the detection of carotid lesions in asymptomatic patients, the cost and risk associated with potentially unnecessary follow-up testing and the risk of unnecessary surgical procedures are arguments againt the wider application of carotid sonography in asymptomatic indivduals. (medscape.com)
  • An analysis of perioperative surgical mortality and morbidity in the asymptomatic carotid atherosclerosis study. (medscape.com)
  • Asymptomatic Carotid Atherosclerosis Study. (medscape.com)
  • 2. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. (clotcare.com)
  • The use of carotid duplex ultrasonography has been widely recommended as a sceening examination. (medscape.com)
  • However, a recent review and meta-analysis published by the U.S. Preventive Services Task Force recommended against the usefulness of carotid duplex ultrasonography as a screening test in asymptomatic individuals. (medscape.com)
  • The detection of a carotid bruit is a common physical examination finding that may lead to a referral for carotid duplex ultrasonography. (medscape.com)
  • Carotid duplex ultrasonography (US) is a noninvasive means by which to estimate the degree of cervical carotid stenosis. (medscape.com)
  • Carotid artery kinking is a frequent finding in duplex ultrasonography. (bioportfolio.com)