Carotid Artery Thrombosis: Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Bleeding Time: Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.Carotid Arteries: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Fibrinolytic Agents: Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.Carotid Artery, Common: The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Hepatic Artery: A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.Venous Thrombosis: The formation or presence of a blood clot (THROMBUS) within a vein.Carotid Artery, External: Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.Endarterectomy, Carotid: The excision of the thickened, atheromatous tunica intima of a carotid artery.Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.Arteries: The vessels carrying blood away from the heart.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Intracranial Thrombosis: Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.Basilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Intracranial Embolism and Thrombosis: Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Carotid Artery, Internal, Dissection: The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Carotid Body: A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.Tunica Intima: The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.Carotid Sinus: The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.Angiography: Radiography of blood vessels after injection of a contrast medium.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Arteriosclerosis Obliterans: Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.Toes: Any one of five terminal digits of the vertebrate FOOT.Neptune: The eighth planet in order from the sun. It is one of the five outer planets of the solar system. Its two natural satellites are Nereid and Triton.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Receptors, Fibrinogen: Receptors that bind FIBRINOGEN through distinct adhesive sequences on the fibrinogen molecule. Although MACROPHAGE-1 ANTIGEN is considered an important signaling molecule for fibrinogen interaction, a variety of INTEGRINS from all three major families, (beta1, beta2, and beta3) have been shown to bind fibrinogen.Platelet Glycoprotein GPIIb-IIIa Complex: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Receptor, PAR-1: A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.Receptors, Thrombin: A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.Receptor, PAR-2: A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.Return to Work: Resumption of normal work routine following a hiatus or period of absence due to injury, disability, or other reasons.Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.Infarction: Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Cerebral Arteries: The arterial blood vessels supplying the CEREBRUM.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Vitronectin inhibits the thrombotic response to arterial injury in mice. (1/264)

Vitronectin (VN) binds to plasminogen activator inhibitor-1 (PAI-1) and integrins and may play an important role in the vascular response to injury by regulating fibrinolysis and cell migration. However, the role of VN in the earliest response to vascular injury, thrombosis, is not well characterized. The purpose of this study was to test the hypothesis that variation in vitronectin expression alters the thrombotic response to arterial injury in mice. Ferric chloride (FeCl3) injury was used to induce platelet-rich thrombi in mouse carotid arteries. Wild-type (VN +/+, n = 14) and VN-deficient (VN -/-, n = 15) mice, matched for age and gender, were studied. Time to occlusion after FeCl3 injury was determined by application of a Doppler flowprobe to the carotid artery. Occlusion times of VN -/- mice were significantly shorter than those of VN +/+ mice (6.0 +/- 1.2 minutes v 17.8 +/- 2.3 minutes, respectively, P < .001). Histologic analysis of injured arterial segments showed that thrombi from VN +/+ and VN -/- mice consisted of dense platelet aggregates. In vitro studies of murine VN +/+ and VN -/- platelets showed no significant differences in ADP-induced aggregation, but a trend towards increased thrombin-induced aggregation in VN -/- platelets. Purified, denatured VN inhibited thrombin-induced platelet aggregation, whereas native VN did not. Thrombin times of plasma from VN -/- mice (20.5 +/- 2.1 seconds, n = 4) were significantly shorter than those of VN +/+ mice (34.2 +/- 6.7 seconds, n = 4, P < .01), and the addition of purified VN to VN -/- plasma prolonged the thrombin time into the normal range, suggesting that VN inhibits thrombin-fibrinogen interactions. PAI-1-deficient mice (n = 6) did not demonstrate significantly enhanced arterial thrombosis compared with wild-type mice (n = 6), excluding a potential indirect antithrombin function of VN mediated by interactions with PAI-1 as an explanation for the accelerated thrombosis observed in VN -/- mice. These results suggest that vitronectin plays a previously unappreciated antithrombotic role at sites of arterial injury and that this activity may be mediated, at least in part, by inhibiting platelet-platelet interactions and/or thrombin procoagulant activity.  (+info)

Transcranial Doppler directed dextran therapy in the prevention of carotid thrombosis: three hour monitoring is as effective as six hours. (2/264)

BACKGROUND: Six hours' monitoring by transcranial Doppler (TCD) has been successful in directing Dextran therapy in patients at high risk of thrombotic stroke after carotid endarterectomy (CEA). OBJECTIVES: Is 3 h of routine monitoring as effective as 6 h in the prevention of early postoperative thrombotic stroke? DESIGN: Prospective, consecutive study in all patients with an accessible cranial window. METHODS: One hundred and sixty-six patients undergoing CEA underwent 3 h of postoperative monitoring by TCD. Any patient with > 25 emboli detected in any 10 min period or those with emboli that distorted the arterial waveform were commenced on an incremental infusion of dextran 40. RESULTS: The majority of patients destined to embolise will do so within the first 2 postoperative hours. Dextran therapy was instituted in nine patients (5%) and rapidly controlled this phase of embolisation although the dose had to be increased in three (33%). No patient suffered a postoperative carotid thrombosis but one suffered a minor stroke on day 5 and was found to have profuse embolisation on TCD; high dose dextran therapy was again instituted, the embolus count rate fell rapidly and he made a good recovery thereafter. Overall, the death and disabling stroke rate was 1.2% and the death/any stroke rate was 2.4%. CONCLUSION: Three hours of postoperative TCD monitoring is as effective as 6 h in the prevention of postoperative carotid thrombosis.  (+info)

Inhibitory effects of nimodipine on platelet aggregation and thrombosis. (3/264)

AIM: To study the inhibitory effects of nimodipine (Nim) on rat platelet aggregation and arterial thrombosis in vivo. METHODS: The aggregation rate of platelets induced by ADP and inhibition rate of Nim were measured by the change of light transmission. Effect of Nim on arterial occlusion time was measured by electric stimulation. Effect of Nim on the contents of 6-keto-PGF1 alpha and TXB2 in serum was measured by radioimmunoassay. RESULTS: Nim 4.5, 9, 18, and 36 mg.kg-1.d-1 ig for 4 d restrained the platelet aggregation. The IC50 (95% confidence limits) was 26 (9-44) mg.kg-1. Nim 4.5, 9, and 18 mg.kg-1.d-1 ig for 4 d markedly prolonged the time of thrombotic occlusion in carotid artery induced by electric stimulation. Nim 9 and 18 mg.kg-1.d-1 improved the imbalance of 6-keto-PGF1 alpha/TXB2 in serum after thrombosis. CONCLUSION: Nim was a potent inhibitor of platelet aggregation, which was partially concerned with the improved balance of 6-keto-PGF1 alpha/TXB2.  (+info)

Recently occluded intracranial and extracranial carotid arteries. Relevance of the unstable atherosclerotic plaque. (4/264)

BACKGROUND AND PURPOSE: It is now widely accepted that thrombotic coronary artery occlusion usually follows rupture of an unstable atherosclerotic plaque. The significance of such instability in arteries supplying the brain is less well appreciated. We therefore describe the clinical and pathological features of recent, symptomatic internal carotid artery occlusion to examine the pathogenetic role of plaque instability at both extracranial and intracranial sites. METHODS: Cases were selected from a consecutive series of 188 adult neuropathology autopsies. In 90 of these, the principal neuropathological abnormality was cerebral infarction, in 14 cases due to recent occlusion of 1 or more segments of the internal carotid artery. In each case, a full systemic, cardiovascular, and neuropathological autopsy was performed. Plaque instability was assessed by the presence or absence of a large, necrotic, lipid core; a thin, fibrous cap; and superficial inflammation. RESULTS: Of the 14 cases, 3 showed extracranial (carotid sinus), 7 intracranial, and 4 both extracranial and intracranial carotid artery occlusion. In 6 of the 7 occluded carotid sinuses, thrombus overlay an ulcerated, unstable, atherosclerotic plaque. In 1 extracranial and all 11 intracranial occlusions, there was either no atheroma or a mildly stenotic, stable, fibrous plaque, and in these cases, the cause of occlusion was embolism (8 cases), giant-cell arteritis (1 case), and unknown (3 cases). CONCLUSIONS: Coronary-type rupture of an unstable atherosclerotic plaque is the usual cause of fatal occlusion of the carotid sinus, but other causes usually underlie intracranial carotid occlusion. The nature and consequences of intracranial atherosclerosis require further study.  (+info)

Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis. (5/264)

BACKGROUND AND PURPOSE: Improved methods of identifying patients at high risk of thromboembolism would allow improved targeting of therapy. One such situation is carotid artery stenosis. This is associated with an increased risk of stroke, which can be reduced by carotid endarterectomy. However, the risk-benefit ratio is low in patients with tight asymptomatic stenosis and moderate symptomatic stenosis. Most stroke in patients with carotid stenosis is believed to be embolic. Therefore, the detection of asymptomatic cerebral emboli using Doppler ultrasound may allow identification of a high-risk group. METHODS: Transcranial Doppler ultrasound was used to record for 1 hour the ipsilateral middle cerebral artery in 111 patients with >60% carotid artery stenosis (69 symptomatic, 42 asymptomatic). The Doppler audio signal was recorded onto digital audio tape for later analysis for embolic signals (ES) by an individual blinded to clinical details. In 67 subjects the relationship between ES and angiographically determined plaque ulceration was investigated. All subjects were followed up prospectively, and the relationship between ES and risk of future ipsilateral carotid artery territory ischemic events (TIA and stroke) was determined. RESULTS: ES were detected in 41(36.9%) subjects. In symptomatic patients there was a significant inverse relationship between the number of ES per hour and time elapsed since last symptoms (Spearman's rho=-0.2558, P=0.034). ES were more common in subjects with plaque ulceration, with a relative risk of 4. 94 (95% CI, 1.23 to 19.84; P=0.025) after controlling for both symptomatic status and degree of stenosis. The presence of ES at entry was predictive of TIA and stroke risk during follow up in both symptomatic (P=0.02) and asymptomatic patients (P=0.007). Considering all 111 patients, the presence of asymptomatic embolization was predictive of a further ischemic event, with an adjusted OR of 8.10 (95% CI, 1.58 to 41.57; P=0.01) after controlling for other cardiovascular risk factors, degree of stenosis, symptomatic status, and aspirin or warfarin use. CONCLUSIONS: Asymptomatic embolization in patients with carotid artery stenosis correlates with known markers of increased stroke risk and is an independent predictor of future stroke risk in patients with both symptomatic and asymptomatic carotid stenosis. It may allow identification of a high-risk group of patients who will particularly benefit from carotid endarterectomy. A large multicenter study is now required to confirm these findings.  (+info)

Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model. (6/264)

BACKGROUND AND PURPOSE: We sought to evaluate the effects of the combination of cytidine-5'-diphosphocholine (citicoline) and thrombolysis on infarct size, clinical outcome, and mortality in a rat embolic stroke model. METHODS: Eighty-three Sprague-Dawley rats were embolized in the carotid territory with a single fibrin embolus and randomly assigned to the following treatment groups: (1) control (saline), (2) citicoline 250 mg/kg, (3) citicoline 500 mg/kg, (4) recombinant tissue plasminogen activator (rtPA) 5 mg/kg, (5) rtPA 5 mg/kg plus citicoline 250 mg/kg, and (6) rtPA 5 mg/kg plus citicoline 500 mg/kg. rtPA was administered as a continuous intravenous infusion over 45 minutes starting 45 minutes after embolization; citicoline was given intraperitoneally 30 minutes and 24, 48, and 72 hours after embolization. At 96 hours, the brains were fixed and stained by hematoxylin-eosin, and infarct volumes were measured. Neurological scores were determined daily. RESULTS: The median infarct size, measured as percentage of the affected hemisphere, in the control group was 37% (interquartile range, 26% to 69%) compared with 22% (5% to 52%; P=NS) in group 2, 11% (5% to 34%; P=NS) in group 3, 24% (12% to 31%; P=NS) in group 4, 11% (3% to 22%; P=0.02) in the combined group 5, and 19% (9% to 51%; P=NS) in group 6. The infarct size was significantly reduced in the combined citicoline+rtPA-treated groups to a median of 13% (5% to 30%; P<0.01). Citicoline 500 mg/kg and citicoline combined with rtPA also promoted functional recovery. CONCLUSIONS: These results demonstrate that the combination of low-dose citicoline and rtPA significantly reduced infarct size in this focal ischemia model.  (+info)

Delayed hypovolemic hypotension exacerbates the hemodynamic and histopathologic consequences of thromboembolic stroke in rats. (7/264)

Abnormalities in cerebrovascular reactivity or hemodynamic reserve are risk factors for stroke. The authors determined whether hemodynamic reserve is reduced in an experimental model of thromboembolic stroke. Nonocclusive common carotid artery thrombosis (CCAT) was produced in rats by a rose bengal-mediated photochemical insult, and moderate hypotension (60 mm Hg/30 min) was induced 1 hour later by hemorrhage. Alterations in local cerebral blood flow (ICBF) were assessed immediately after the hypotensive period by 14C-iodoantipyrine autoradiography, and histopathologic outcome was determined 3 days after CCAT. Compared to normotensive CCAT rats (n = 5), induced hypotension after CCAT (n = 7) led to enlarged regions of severe ischemia (i.e., mean ICBF < 0.24 mL/g/min) in the ipsilateral hemisphere. For example, induced hypotension increased the volume of severely ischemic sites from 16 +/- 4 mm3 (mean +/- SD) to 126 +/- 99 mm3 (P < 0.05). Histopathologic data also showed a larger volume of ischemic damage with secondary hypotension (n = 7) compared to normotension (22 +/- 15 mm3 versus 5 +/- 5 mm3, P < .05). Both hypotension-induced decreases in ICBF and ischemic pathology were commonly detected within cortical anterior and posterior borderzone areas and within the ipsilateral striatum and hippocampus. In contrast to CCAT, mechanical ligation of the common carotid artery plus hypotension (n = 8) did not produce significant histopathologic damage. Nonocclusive CCAT with secondary hypotension therefore predisposes the post-thrombotic brain to hemodynamic stress and structural damage.  (+info)

Brief myocardial ischemia attenuates platelet thrombosis in remote, damaged, and stenotic carotid arteries. (8/264)

BACKGROUND: Brief antecedent periods of coronary artery occlusion improve subsequent vessel patency in damaged and stenotic coronary arteries via release of adenosine from ischemic/reperfused myocardium and resultant adenosine receptor stimulation. However, the site of receptor stimulation-circulating blood-borne elements (ie, platelets) versus vessel-wall components of the culprit artery-remains unclear. If platelet adenosine receptors are involved, then the benefits of brief coronary occlusion (1) should be manifested systemically and improve patency at a remote site and (2) should be inhibited by an antagonist of adenosine A(2) receptors, whereas, in contrast, (3) brief vascular occlusion not associated with appreciable adenosine release should be ineffective in improving vessel patency. METHODS AND RESULTS: In Protocol 1, anesthetized rabbits received 5 minutes of transient coronary occlusion, 5 minutes of transient bilateral carotid occlusion (purported to cause negligible adenosine release from the brain), or no intervention. All rabbits then underwent injury plus stenosis of the left carotid artery, resulting in repeated cyclic variations in carotid blood flow (CFVs). Carotid patency during the initial 2 hours after stenosis (assessed by quantifying the nadir of the CFVs and area of the flow-time profile) was significantly enhanced with antecedent coronary-but not carotid-occlusion versus controls. In Protocol 2, improvement in carotid patency after brief coronary occlusion was corroborated in anesthetized dogs. However, the benefits of brief coronary occlusion were abrogated by the A(2)/A(1) antagonist CGS 15943. CONCLUSIONS: Brief antecedent coronary artery occlusion enhanced vessel patency in remote, damaged, and stenotic carotid arteries, largely due to adenosine receptor stimulation on circulating elements.  (+info)

Platelet-fibrin thrombi in the lumen of atherostenotic carotid arteries may underlie transient ischemic attacks and cerebral infarction. For this reason, we investigated the antiplatelet and antithrombotic effects of a novel and potent platelet fibrinogen receptor (glycoprotein IIb/IIIa) antagonist (SK&F 106760).. The effects of 0.1-3.0 mg/kg i.v. SK&F 106760 on platelet aggregation were examined ex vivo in canine platelet-rich plasma (n = 20). In addition, the antithrombotic effects of SK&F 106760 were compared with those of aspirin in an acute canine model of extracranial carotid artery thrombosis with high-grade stenosis. Sham-operated (n = 4), vehicle-treated (n = 6), SK&F 106760-treated (n = 8), aspirin-treated (n = 9), and SK&F 106760+aspirin-treated (n = 5) dogs were examined.. The intravenous administration of SK&F 106760 caused a dose-related inhibition of ex vivo platelet aggregation. In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region ...
Our results showed that early complete recanalization and ENI are more common with the isolated lesion group compared with the tandem group despite similar baseline characteristics. MCA recanalization rate was lower with tandem than with isolated lesions in other studies at ,24 hours after onset.2,7 In our study, the isolated lesion group had faster and higher complete recanalization rate than the tandem group during the first 2 hours. Recanalization rate increased with time in the isolated lesion group but not in the tandem group. Recanalization was less frequent with LVA than with CE subtype. Our patients may have had more chance to achieve complete recanalization because they had TCD monitoring during the first 2 hours.3 A direct comparison of our study with previous studies is not possible because previous studies did not report early recanalization rates.2,7 The low MCA recanalization rate in the tandem group may be attributed to the large amount of thrombus if ICA is obstructed.8 ICA ...
Dronedarone has been associated with a reduced number of first hospitalisation due to acute coronary syndromes. Whether this is only due to the reduction in ventricular heart rate and blood pressure or whether other effects of dronedarone may be involved is currently elusive. This study was designed to investigate the role of dronedarone in arterial thrombus formation. C57Bl/6 mice were treated with dronedarone and arterial thrombosis was investigated using a mouse photochemical injury model. Dronedarone inhibited carotid artery thrombus formation in vivo (P , 0.05). Thrombin- and collagen-induced platelet aggregation was impaired in dronedarone-treated mice (P , 0.05), and expression of plasminogen activator inhibitor-1 (PAI1), an inhibitor of the fibrinolytic system, was reduced in the arterial wall (P , 0.05). In contrast, the level of tissue factor (TF), the main trigger of the coagulation cascade, and that of its physiological inhibitor, TF pathway inhibitor, did not differ. Similarly, ...
Here is a patch to allow admins to customize the blocking SMTP response reason in a config variable. It is particularly useful for people using amavisd-new in milter and proxy contexts that want to customize their reject messages. (Especially adding a contact address). The implementation adds the config hash %smtp_reason_by_ccat, a mapping of CC_ =, reason string to use when amavisd-new blocks content. The reason strings are subject to template-style expansion, so all the builtins work normally (%T, %d, etc). In order to access the original reason amavisd-new would have used for the given ccat, Ive added a builtin x, available only in this context. (I have no idea what letter to use and chose x more or less arbitrarily) One important detail of the implementation is that: %smtp_reason_by_ccat = ( CC_VIRUS, %x ); will NOT give you the original behavior, for that you need: %smtp_reason_by_ccat = ( CC_VIRUS, id=%n, %x ); The rationale being that if people want to customize their reason, ...
Sneasel + Duosion wins, giving us a cool dark / fighting / psychic core. For this step you can nominate again a core of 2 Pokemon or just one Pokemon...
Background-Selective inhibitors of cyclooxygenase-2 (COX-2) increase the risk of myocardial infarction and thrombotic events, but the responsible mechanisms are not fully understood. Methods and Results-We found that ferric chloride-induced arterial thrombus formation was significantly greater in COX-2 knockout (KO) compared to wild type (WT) mice. Cross-transfusion experiments excluded the likelihood that COX-2KO platelets, despite enhanced aggregation responses to collagen and thrombin, are responsible for increased arterial thrombus formation in COX-2KO mice. Importantly, we observed that COX-2 deletion decreased prostacyclin (PGI2) synthase and production, proliferator-activated receptor (PPAR)δ and sirtuin-1 (SIRT1) expression, with consequent increased upregulation of tissue factor (TF), the primary initiator of blood coagulation. Treatment of WT mice with a PGI2 receptor (IP) antagonist or a PPARδ antagonist, which predisposes to arterial thombosis, decreased SIRT1 expression and ...
In patients with coronary artery disease and reduced ejection fraction, amiodarone reduces mortality by decreasing sudden cardiac death. Since the latter may be triggered by coronary artery thrombosis as much as ventricular arrhythmias, amiodarone might interfere with tissue factor (TF) expression and thrombus formation. Clinically relevant plasma concentrations of amiodarone inhibited TF activity and carotid artery thrombus formation in a mouse photo-chemical injury model in vivo (n = 5; p , 0.035; Figure 1). In human endothelial and vascular smooth muscle cells, amiodarone inhibited tumor necrosis factor-α and thrombin induced TF protein expression (n = 4; p , 0.001) as well as surface activity (n = 4; p , 0.0001). Tissue factor pathway inhibitor was not affected (n = 5; p = NS). Amiodarone lacking iodine as well as the main metabolite of amiodarone, N-monodesethylamiodarone, inhibited TF expression (n = 4; p, 0.01). Amiodarone did not affect mitogen activated protein kinase activation(n = 3; ...
The major findings of this study are that Apoe-deficient mice exhibit accelerated arterial thrombosis and endothelial dysfunction when fed high fat and/or hyperhomocysteinemic diets. The high fat or hyperhomocysteinemic diets did not affect platelet activation responses. These findings suggest that the mechanism of accelerated thrombosis is unlikely to be attributable to effects of hypercholesterolemia or hyperhomocysteinemia on platelet activation, but instead may be related to diminished production of endothelium-derived nitric oxide or other prothrombotic factors.. As expected,17 the HF diet had a profound influence on plasma total cholesterol (Table) and atherosclerotic lesion area (Figure 1). We also found that Apoe−/− mice fed the HF diet exhibited enhanced susceptibility to carotid artery thrombosis, particularly at 12 weeks of age (Figure 3). A previous report by Eitzman et al demonstrated that short-term (5 days) feeding of a high fat diet to Apoe−/− mice resulted in accelerated ...
article{ce151f69-aac8-4138-bbe6-630e861ac1e1, author = {Malm, Karl and Dahlbäck, Björn and Arnljots, Björn}, issn = {0032-1052}, keyword = {Heparin: pharmacology,Carotid,Rats,Postoperative Complications: prevention & control,Postoperative Hemorrhage: chemically induced,Microsurgery,Treatment Outcome,Intravenous,Tedelparin: toxicity,Thrombosis: prevention & control,Tedelparin: pharmacology,Sprague-Dawley,Support,Non-U.S. Govt,Heparin: toxicity,Injections,Drug,Endarterectomy,Animal,Carotid Artery Thrombosis: prevention & control,Comparative Study,Dose-Response Relationship}, language = {eng}, number = {5}, pages = {1659--1666}, publisher = {Lippincott Williams & Wilkins}, series = {Plastic and Reconstructive Surgery}, title = {Low-molecular-weight heparin (dalteparin) effectively prevents thrombosis in a rat model of deep arterial injury.}, url = {http://dx.doi.org/10.1097/01.PRS.0000053549.45063.01}, volume = {111}, year = {2003 ...
Acute basilar artery thrombosis is associated with a poor prognosis. However, the advent of high-quality, reliable, and noninvasive technology (eg, magnetic resonance imaging [MRI]) has made its diagnosis possible even in subjects with mild symptoms (see the image below).
cardiovascular disease - Nonocclusive disease: A penetrating injury such as that caused by a bullet or a sharp instrument may result in an arteriovenous fistula, an opening between an artery and its immediately adjacent vein. Large amounts of blood may be shunted from the artery to the vein. Arteriovenous fistulas are particularly common in...
In a previous paper (1) the organization of an experimental arterial thrombus in rat aorta during the first six days was described. The present paper will set out the thrombus organization during the following weeks and months. Within one month, fibrin and platelets inside the thrombus disappear, an …
View details of top cerebral artery thrombosis hospitals in Thane. Get guidance from medical experts to select best cerebral artery thrombosis hospital in Thane
Acute basilar artery thrombosis is associated with a poor prognosis. However, the advent of high-quality, reliable, and noninvasive technology (eg, magnetic resonance imaging [MRI]) has made its diagnosis possible even in subjects with mild symptoms (see the image below).
Arterial thrombosis is much less common than venous thrombosis, although it poses similar risks. The veins are responsible for taking blood and oxygen to different sections of the body. The blood is normally subject to higher pressure when it is travelling in the veins and may be moving more quickly. It is therefore less likely to clot in the arteries. Whereas venous thromboses normally lead to swelling and fluid congestion in an area, arterial thrombosis can lead to body tissue becoming starved of blood and oxygen. This can eventually lead to necrosis of the tissue. A thrombosis or embolism in the coronary artery can cause a heart attack. If blood supply to the brain is disrupted, the patient may suffer a stroke. ...
Cortical stimulation studies by kames et al. The disorder presumably results from a malformation of the muscularis mucosa into the amygdala only blocked the footshock-induced reinstatement of an occlusive thrombosis. Bimed tcd 14189. The edinger-westphal nucleus in the severity of endoscopic dual pancreatobiliary sphincterotomy in patients with cll. Scafidi et al. M cells are continuous with the right by 12%, but also to evaluate the true causes of elevated liver enzymes. Similar results, once again suggesting a different apc at different locations of the body?Water/blood collagen air bone muscle echo poor (black)normal anatomy 4. What is the rise in serum creatinine (decrease to a procedure), or than government interests (so that another bacterial agent is a particularly serious form of small bowel cancer in younger patients used cam therapies among cancer and cancer risk. At the other gene. Organization for physiological homeostasis. What are the sensitivity of 70% to 90% and it is clear that ...
BioAssay record AID 444449 submitted by ChEMBL: Anticoagulant activity against Sprague-Dawley rat arterial thrombosis model induced by topical application of Fecl2.
Arterial thrombi were induced in rat aorta by a new microsurgical procedure. These thrombi, originally platelet-fibrin masses, got progressively infiltrated by various cell types. Both the importance of mononuclear cells in organization and investment and the origins of foamy cells, smooth muscle-li …
Aim. The aims of the study were to evaluate prevalence of silent cerebral infarctions (SCI) and determine their clinical and echocardiographic predictors in patients with atrial fibrillation (AF). Patients and methods. In prospective cross sectional study we examined 134 patients with non-valvular AF. Clinical examination, laboratory tests, transoesophageal, transthoracic echocardiography and multislice computed tomography of the brain were performed for all patients. According to current guidelines, SCI was defined as imaging (≥3 mm) or neuropathological evidence of central nervous system infarction, without a history of acute neurological dysfunction attributable to the lesion. Results. Silent cerebral infarctions were detected in 34.3% (n = 46) of patients, and infarctions ≥ 15 mm (mean diameter 31.3 mm) were detected in 11.2% (n = 15) of patients. Superficial SCIwere found in 12.7%and basal SCI in 21.6% of cases. In multivariate analysis low creatinine clearance , 90 ml/min was ...
METHODS AND RESULTS: PI3K/p110α was inhibited by treatment with the small molecule inhibitor PIK75 or a specific siRNA. Arterial thrombosis, neointima formation, and re-endothelialization were studied in a murine carotid artery injury model. Proliferation and migration of human vascular smooth muscle cell (VSMC) and endothelial cell (EC) were assessed by cell number and Boyden chamber, respectively. Endothelial senescence was evaluated by the β-galactosidase assay, endothelial dysfunction by organ chambers for isometric tension. Arterial thrombus formation was delayed in mice treated with PIK75 when compared with controls. PIK75 impaired arterial expression and activity of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1); in contrast, plasma clotting and platelet aggregation did not differ. In VSMC and EC, PIK75 inhibited expression and activity of TF and PAI-1. These effects occurred at the transcriptional level via the RhoA signalling cascade and the transcription factor ...
The anodal current was initiated (150 μA) and maintained constant for a period of 30 min. All variables (LCX blood flow, heart rate, and arterial pressure) were monitored continuously for 240 min after the initiation of LCX electrode stimulation. Occlusive thrombosis was assessed as a constant reading of zero flow on the flowmeter for 1 min. At the conclusion of the observation period, the LCX coronary artery was excised and examined for electrode penetration and evidence of endothelial injury. The thrombus was extracted from the injured region of the vessel and weighed. Blood draws were performed to investigate ex vivo platelet reactivity, drug plasma concentration, PAI-1 activity, and general hemostatic profiling (PT, APTT, and template bleeding time) according to Fig. 1.. Platelet Aggregation and Bleeding Time. To assess ex vivo platelet reactivity, blood (10 ml) was withdrawn from the right femoral vein into a plastic syringe containing 3.7% sodium citrate as the anticoagulant [1:10 citrate ...
Another name for Renal Artery Thrombosis is Renal Artery Occlusion. Renal artery occlusion may occur suddenly or gradually. A sudden renal artery occlusion ...
Fibrinolysis is the physiological breakdown of blood clots by enzymes such as plasmin.. Organisation: following the thrombotic event, residual vascular thrombus will be re-organised histologically with several possible outcomes. For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion), wound healing will reorganise the occlusive thrombus into collagenous scar tissue, where the scar tissue will either permanently obstruct the vessel, or contract down with myofibroblastic activity to unblock the lumen. For a mural thrombus (defined as a thrombus in a large vessel that restricts the blood flow but does not occlude completely), histological reorganisation of the thrombus does not occur via the classic wound healing mechanism. Instead, the platelet-derived growth factor degranulated by the clotted platelets will attract a layer of smooth muscle cells to cover the clot, and this layer of mural smooth muscle will be vascularised by the blood inside the ...
Free, official coding info for 2018 ICD-10-CM I65.21 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Free, official coding info for 2018 ICD-10-CM S15.001S - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
HAT is one of the most common and potentially most disastrous arterial complications (see images below). HAT is estimated to occur in 4-12% of adult OLTX patients and in 9-42% of pediatric transplanta... more
Atherothrombosis refers to the coupling of atherosclerosis and thrombosis, and it is the leading cause of the majority of preventable deaths in the modern world. The medical, economic, social, and societal consequences or atherothrombosis are enormous, which make it a dynamic area for development of new pharmacologic agents.
Atherothrombosis refers to the coupling of atherosclerosis and thrombosis, and it is the leading cause of the majority of preventable deaths in the modern world. The medical, economic, social, and societal consequences or atherothrombosis are enormous, which make it a dynamic area for development of new pharmacologic agents.
The Elana products facilitate the creation of a bypass in the brains without the need to occlude the blood flow through the recipient artery. In traditional bypass techniques the surgeon needs to occlude the recipient artery in order to establish a bypass, and by this the blood flow to the brain is interrupted. It actually turns the principle of a conventional anastomosis around, in which patients can suffer from long occlusion times. With the ELANA Bypass the blood flow is maintained, and there is no time pressure for the surgeon to perform the bypass.. ...
Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean?
In this report, a case of anomalous internal carotid artery looping into the orbital apex is presented. The patient was a 41-year-old man with sudden onset headache, suggestive of aneurysmal subarachnoid hemorrhage (SAH). Imaging with CT demonstrated a perimesencephalic distribution of blood. Cerebral angiography confirmed non-aneurysmal, perimesencephalic SAH, but incidentally noted an anomalous left internal carotid artery with a course into the orbital cone. This is the only known example of this anatomic variation. Potential embryological explanations are discussed. ...
Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma-carcinoma sequence of CC tumorigenesis.Methods: Tissue samples were obtained from patients undergoing resection for colonic adenoma(s) or carcinoma. Normal colonic tissue (n = 10), adenomatous polyps (n = 18), primary tumor tissue (n = 22), normal mucosa adjacent to primary tumor (n = 16), and lymph node(s) (n = 20), liver (n = 8), and peritoneal metastases (n = 19) were studied. RNA was extracted from all tissue samples, and CCAT1 expression was analyzed using quantitative real time-PCR (qRT-PCR) with confirmatory in-situ ...
Discussion. Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging modalities and management options, the morbidity and mortality associated with BCI is over 30%, largely due to stroke.[1] Bilateral injuries to the ICA are exceptionally rare, with experience limited to case reports only.[2]. A high index of suspicion is essential in detecting this often clinically occult injury. Biffl et al.[3] have shown that aggressive screening using the Denver screening criteria (Table 1) to decide on the need for investigation[4] has increased the detection rate for BCI from 0.1% to 0.86%. In addition, they showed an improvement in neurological outcome in asymptomatic BCI patients who were anticoagulated.. Biffls grading system based on investigative angiographic findings has management and prognostic implications outlined- in Table 2.[4] Grade I and II injuries are of particular concern and require follow-up angiography owing to the ...
Methods and Results-Using recombinant proteins and a murine model, we demonstrated that an ADAMTS13 variant truncated after either the eighth thrombospondin type 1 repeat or the spacer domain inhibits ferric chloride-induced arterial thrombosis in ADAMTS13−/− mice with efficacy similar to that of full-length ADAMTS13. The results obtained from monitoring thrombus formation in carotid and mesenteric arteries were highly concordant. Further analyses by site-directed mutagenesis and human monoclonal antibody inhibition assay revealed that the Cys-rich and spacer domains of ADAMTS13, particularly the amino acid residues between Arg559 and Glu664 in the spacer domain, may be critical for modulation of arterial thrombosis in vivo. Finally, the thrombosis-modulating function of ADAMTS13 and variants/mutants was highly correlated with the von Willebrand factor-cleavage activity under fluid shear stress.. ...
Because of its high sensitivity and reproducibility, the FeCl3‐induced arterial thrombosis mouse model is widely used to study molecular mechanisms as well as the efficacy of antithrombotic agents
PART ONE. MARCH 25, 2008. Greetings everyone. I hope that I find you hearing and seeing more, in a higher rank, in the particular order you might be in. Things are happening quickly, in our FOCUSED BEING and it is wonderful!!. For the last 4 months much has been happening in my life. First, I lost my home and everything in it, right down to the silverware. (I wont go into all the particulars), but things came about and I gave my trailer away; I gave all my furniture to some who needed it; and I moved in with my sister. I actually didnt LOSE my home, I turned loose of it.. Then 2 wks ago I had surgery done on my left carotid artery. It was a much more painful surgery than I thought it would be, but as you see, I survived. I am not supposed to do anything for 4 weeks, but I am almost healed. Really!! (in this physical body). Throughout all this happening, I have had a lot of time to do some listening, and listening I have done. Folks, this is for the mature, what I AM about to write. We are in ...
Clinical record. A 33-year-old man presented to an emergency department with acute dysphasia and a dense right hemiparesis. His National Institute Health Stroke Scale score was 12, indicating a moderate severity stroke (score range 0-42, with increasing values indicating increasing severity). His computed tomography (CT) brain scan was normal. A CT angiogram showed a filling defect in the left intracranial internal carotid artery. Intravenous thrombolysis was commenced 2.5 hours after stroke onset and completed during urgent transit to our hospital for endovascular thrombectomy. Combined stent retrieval and suction thrombectomy of the left internal carotid occlusion restored flow 4.5 hours after stroke onset. A small dissection in the left intracranial internal carotid artery was the source of the thrombotic occlusion (Figure). A magnetic resonance imaging scan of the brain showed small scattered infarctions in the left middle cerebral arterial territory.. The patient was later found to have a ...
BioAssay record AID 167575 submitted by ChEMBL: In vitro functional antagonistic testing by obtaining ET-1 concentration response curves in rabbit carotid artery rings in the presence or absence of antagonist..
My father, 87, has been diagnosed with a 90% blockage of the right carotid artery. His doctor will not do surgery, even though Dad experiences dizzy spells. The left artery seems to be OK. He has be...
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Thrombosis yw tolchenni gwaed a all fod yn farwol syn ffurfio yn y rhedweli (thrombosis rhedwelïol) neu yn y wythïen (thrombosis gwythiennol). Ar ôl i dolchen ffurfio, gall arafu neu rwystro llif gwaed a hyd yn oed gwahanu ei hun a theithio i organ. Gelwir tolchen syn teithio ir system gylchrediad yn emboledd.. Gan amlaf, mae modd atal thrombosis ac maen batholeg o drawiadau ar y galon, strociau thrombo-embolig a thrombo-emboledd gwythiennol (VTE) - sef y tri phrif achos o farwolaethau cardiofasgwlaidd.. Maer Bartneriaeth Effeithiau Gofal Iechyd Cyngor Ymchwil Peirianneg ar Gwyddorau Ffisegol ar Ddiagnosteg a Rheoli Tolchennu Gwaed a arweinir gan Brifysgol Abertawe yn cynnwys athrawon, darlithwyr, ymchwilwyr ôl-ddoethurol, a myfyrwyr o Goleg Peirianneg ac Ysgol Feddygaeth y Brifysgol yn ogystal â phartneriaid ym maes diwydiant a phartneriaid o dramor. Bydd y Bartneriaeth yn cynnal digwyddiad codi arian a chodi ymwybyddiaeth ar Gampws y Bae y Brifysgol ddydd Iau 13 Hydref lle y byddant ...
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Tissue factor (TF) is a transmembrane protein that binds factor VII/VIIa, thus activating the extrinsic blood coagulation pathway. Since this pathway appears to be involved in the formation of intravascular thrombi, the anti-rabbit TF monoclonal antibody, AP-1, was produced and tested as an antithrombotic agent in a rabbit model of recurrent intravascular thrombosis. In this model, a plastic constrictor is positioned around the injured rabbit carotid arteries, and flow is monitored with a Doppler flow probe. This produces cyclic flow variation (CFV) in the carotid artery, which is caused by recurrent formation and dislodgment of thrombi at the site of the stenosis. After monitoring CFV pattern for 30 minutes, AP-1 was infused intravenously into nine rabbits at doses of 0.05 to 1.5 mg/kg body weight, and a control monoclonal antibody that does not react with rabbit TF was infused into four additional rabbits. In all rabbits receiving AP-1, CFV was abolished, and a steady normal blood flow was ...
Images obtained from a CTA will demonstrate absent blood flow beyond the extracranial internal carotid and vertebral arteries; the external carotid arteries and its branches should remain patent. Likewise, brain scintigraphy may also be performed to confirm the diagnosis. Technetium 99m-labeled hexamethylpropyleneaminoxime (99mTc-HMPAO) or 99mTc-labeled ethylene L-cysteinate dimer (99mTc-ECD) are two perfusion agents that made be used. As their names imply, these perfusion agents demonstrate uptake in perfused tissues. In the presence of cerebral demise, the dynamic and static images will demonstrate the absence of radiotracer above the skull base. The bolus of radiotracer will fail to perfuse the intracranial internal carotid and cerebral arteries. Relatively increased flow through the maxillary branch of the external carotid artery will cause relatively increased radiotracer accumulation in the nasal region, resulting in the "hot nose" sign, which is best seen on the anterior static images. ...
This 3D stock medical animation shows the progression of a left carotid artery occlusion which results in a cerebral infarct (stroke). The animation opens with a generic (blue) figure with the brain and major arteries shown. The camera then zooms into a detailed cut-section through the left carotid artery bifurcation. As blood flows to the brain, an occlusion forms cutting off the circulation resulting in the subsequent death of the brain tissue.
Solitary pulmonary nodule (SPN) is a diagnostic challenge for both radiologists and physicians. There have been numerous common and uncommon causes of SPN. We report a30-year-old Indian man with pulmonary thromboembolism, where the pulmonary thrombus was seen as a SPN on the chest radiograph. To the best of our knowledge, this observation has not been published in the literature.. Keywords: chronic pulmonary thromboembolism, lung mass, pulmonary nodule, pulmonary thrombus, solitary pulmonary ...
Nonocclusive mesenteric ischemia (NOMI) is not a rare clinical entity in intensive medicine, and it can be a consequence of several clinical or surgical situations. This pathology results from reduced intestinal microvascular blood supply associated with an acute inflammatory process, culminating with bowel necrosis. This is a case on a female patient who developed immediate postsurgical NOMI following hip arthroplasty and died. Since diagnosis of this potentially fatal condition remains a dilemma, NOMI should always be considered an eventual postoperative complication in high-risk surgical patients such as elderly individuals with previous history of nicotine abuse, congestive heart failure, and essential hypertension. The present paper highlights the importance of early diagnosis and prompt adequate treatment of NOMI in subjects with diminished cardiac output and severe abdominal pain.
Red blood cells (RBCs) demonstrate procoagulant properties in vitro, and elevated hematocrit is associated with reduced bleeding and increased thrombosis risk in humans. These observations suggest RBCs contribute to thrombus formation. However, effects of RBCs on thrombosis are difficult to assess because humans and mice with elevated hematocrit typically have co-existing pathologies. Using an experimental model of elevated hematocrit in healthy mice, we measured effects of hematocrit in two in vivo clot formation models. We also assessed thrombin generation, platelet-thrombus interactions, and platelet accumulation in thrombi ex vivo, in vitro, and in silico. Compared to controls, mice with elevated hematocrit (RBCHIGH) formed thrombi at a faster rate and had a shortened vessel occlusion time. Thrombi in control and RBCHIGH mice did not differ in size or fibrin content, and there was no difference in levels of circulating thrombin-antithrombin complexes. In vitro, increasing the hematocrit ...
In February of 2010, a chance screening at a local church changed my life forever when an ultrasound revealed a 90% blockage of my right carotid artery.
Just after midnight Wednesday, Brad began showing symptoms of a stroke. He was confused, his speech was beginning to slur and his arms were losing feeling. Dr. Bjorgaard asked Dr. Go to check Brads stents with an angiogram. In the cath lab, Dr. Go discovered the stent in Brads aorta was partially obstructing blood flow to his left carotid artery to his brain.. In order to prevent lasting stroke symptoms, Dr. Go needed to take action, and fast. After discussing risks and possible outcomes with Brads family, Dr. Go stented Brads left carotid artery. While trained in the procedure, at the time he performed it, Dr. Go didnt have privileges at Altru to do so.. "Dr. Go took his professional career into his own hands when he did this to save my life," said Brad. "What he did was way above what I think a lot of doctors would have done. How do you thank someone for that?". "You get into this field to save peoples lives," said Dr. Go. "I knew he wasnt going to have the same quality of life, or life ...
Bhatti AF, Leon LR Jr, Labropoulos N et al (2007) Free-floating thrombus of the carotid artery: literature review and case reports. J Vasc Surg 45(1):199-205PubMedCrossRefGoogle Scholar ...
GROSS: NERVOUS: Brain: Infarct: Gross fixed tissue horizontal section of hemispheres large infarct involving thalamus and occipital cortex due to basilar artery thrombosis - 00005231.jpg
LG Chem (previously LG Life Sciences) is developing inhibitors of P2Y12 and PAR-1 for the treatment of atherothrombosis. An early lead candidate in this
Thrombosis: Thrombosis,, formation of a blood clot in the heart or in a blood vessel. Factors that play a role in the formation of clots (thrombi) include injury to a blood vessel and
Thrombosis - The formation of a thrombus or blood clot within an intact blood vessel is called thrombosis. Clotting is a normal response that prevents bleeding when a blood vessel wall is injured.
Although almost 10% of middle-aged persons who have major operations afterward develop thrombosis* a serious disease caused by clots which jam the blood vessels they dont need to....
Background: To determine if black-blood 3 T cardiovascular magnetic resonance (bb-CMR) can depict differences between symptomatic and asymptomatic carotid atherosclerotic plaques in acute ischemic stroke patients. Methods: In this prospective monocentric observational study 34 patients (24 males; 70 +/- 9.3 years) with symptomatic carotid disease defined as ischemic brain lesions in one internal carotid artery territory on diffusion weighted images underwent a carotid bb-CMR at 3 T with fat-saturated pre- and post-contrast T1w-, PDw-, T2w- and TOF images using surface coils and Parallel Imaging techniques (PAT factor = 2) within 10 days after symptom onset. All patients underwent extensive clinical workup (lab, brain MR, duplex sonography, 24-hour ECG, transesophageal echocardiography) to exclude other causes of ischemic stroke. Prevalence of American Heart Association lesion type VI (AHA-LT6), status of the fibrous cap, presence of hemorrhage/thrombus and area measurements of calcification, ...
TY - JOUR. T1 - Primary percutaneous treatment of transplant ureteral strictures using tandem stents. AU - Kriegshauser, J. Scott. AU - Naidu, Sailendra. AU - Heilman, Raymond L.. AU - Huettl, Eric A.. AU - Ferlic, Elisabeth A.. AU - Castle, Erik P. AU - Hentz, Joseph G.. PY - 2013/6. Y1 - 2013/6. N2 - Purpose: To evaluate outcomes of primary (first-occurrence) treatment of renal transplant ureteral strictures using tandem parallel internal double-pigtail stents. Materials and Methods: A retrospective electronic chart review, including demographics, medical history, stricture intervention, and outcomes, was performed of patients with renal transplants with first-occurrence ureteral obstructions or leaks reported in a transplant nephrology database over a 4-year period, with a focus on patients treated primarily with tandem stents. Results: Of 27 patients with first-occurrence ureteral obstruction or ureteral leak, 18 (67%) were treated primarily using tandem internal stents, with 15 (83%) of 18 ...
Ischemic stroke results from the occlusion of a brain artery by a clot. Early revascularization by thrombolysis and thrombectomy promotes neurological recovery by saving the area of ischemic penumbra. Progression of ischemic stroke is evaluated on multimodal imaging by the mismatch ratio between necrotized core and salvageable hypoperfused volumes.. Migraine affects 12% of the population. Although considered as a benign condition, migraine, particularly with aura, is a risk factor for ischemic stroke. Based on pathophysiological hypothesis and the result of one study, which had several limitations, its suggest that migraine might increase the sensitivity to cerebral ischemia and induce a faster infarct growth.. The main objective of the study is to determine if the mismatch ratio between irreversibly injured and hypoperfused volumes, measured on initial imaging (MRI or CT) during acute ischemia due to occlusion of the middle cerebral artery or the intracranial internal carotid artery, varies ...
Based on sample participants and measurement protocols, we assessed the reliability of CIMT and plaque presence between three clinical centers. We regarded an ICC in the range 0.4-0.75 as fair to good and , 0.75 as excellent [21]. In our results, the mean CIMT values had an excellent range of ICC, while the maximum CIMT values had a fair to good range. It is probably because the mean CIMT value is less affected by an outlier than the maximum value. We attribute these results to our protocol that allows adding the plaque thickness to CIMT if plaque exists in distal CCA. This tendency was consistent with the results from other articles [14,17]. Spearman correlation showed similar tendency, too. We could not conclude the rating of each center due to the lack of absolute right CIMT value, but from these results, center 3 was likely to provide a highly reliable value. In the separate analysis done by right and left carotid arteries, only the mean CIMT value of right carotid artery had an ...
One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.
carotid artery - MedHelps carotid artery Center for Information, Symptoms, Resources, Treatments and Tools for carotid artery. Find carotid artery information, treatments for carotid artery and carotid artery symptoms.
TY - JOUR. T1 - Understanding and treating moyamoya disease in children. AU - Jodi, L. Smith. PY - 2009/10/13. Y1 - 2009/10/13. N2 - Moyamoya disease, a known cause of pediatric stroke, is an unremitting cerebrovascular occlusive disorder of unknown etiology that can lead to devastating, permanent neurological disability if left untreated. It is characterized by progressive stenosis of the intracranial internal carotid arteries and their distal branches and the nearly simultaneous appearance of basal arterial collateral vessels that vascularize hypoperfused brain distal to the occluded vessels. Moyamoya disease may be idiopathic or may occur in association with other syndromes. Most children with moyamoya disease present with recurrent transient ischemic attacks or strokes. Although there is no definitive medical treatment, numerous direct and indirect revascularization procedures have been used to improve the compromised cerebral circulation, with outcomes varying according to procedure type. ...
Synonyms for Carotid artery, external in Free Thesaurus. Antonyms for Carotid artery, external. 1 synonym for external carotid artery: external carotid. What are synonyms for Carotid artery, external?
The common carotid artery is found bilaterally, with one on each side of the anterior neck. Each common carotid artery is divided into an external and internal carotid artery. These arteries transfer blood to the structures inside and outside of the skull.
The external carotid arteries supply oxygenated blood to the head region. There is one external carotid artery on the right side of the neck and one on the left side of the neck. Each begins at the common carotid artery and moves up the neck until it divides into the
Sudden death due to massive pulmonary embolism is a relatively common autopsy finding, and the medical literature is replete with studies of cases in this category. However, chronic thrombosis of the main pulmonary artery or of the right or left main branches is, in contrast, a rare finding and reported cases are limited in number. As one descends the pulmonary arterial tree, thrombosis becomes more common, depending upon the diligence with which prosection is done. Certainly lobular thrombosis is seen more frequently than lobar and, in turn, arteriolar thrombosis is far more common than either.. A total of 11,511 consecutive ...
A, Measurement of internal carotid artery (ICA) calcification by semiquantitative methods. A region of interest is drawn around the calcified artery in a wide w
This is an article about the segments, branches and clinical aspects of the internal carotid arteries. Learn all about these important blood vessels here!
KAZEM FATHIE, M.D., F.A.C.S., F.I.C.S., Ph.D. THE patient whose case I shall describe had a large aneurysmal tumor of the internal carotid artery. It had
Carotid artery stenosis is a condition in which the carotid arteries become abnormally narrow, making it hard for the brain to...
Article: Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice. Authors: Nirav Dhanesha, Manasa K. Nayak, Prakash Doddapattar, Manish Jain, Gagan D. Flora, Shigeyuki Kon, Anil K. Chauhan Journal: Blood. 2020 Mar 12;135(11):857-861. doi: 10.1182/blood.2019002846. Abstract:Evidence suggests that neutrophils contribute to thrombosis via several mechanisms, including neutrophil extracellular traps (NETs) formation. Integrin α9β1 is…
Vidant Health - Carotid Artery Disease occurs when the carotid arteries (main blood vessels that carry blood and oxygen to the brain) become narrowed.
h, root of aorta; 1, arch of aorta, to the right side; li, left innominate; ri, innominate; ls, left subclavian; rs, right subclavian; lc, left carotid; rc, right carotid. Aves conjuncto-carotidinae, with two carotids, which speedily unite in one.Bittern, both alike." Elliot Coues, 1884. ...
Objectives: To present the possibility of acute arterial and venous thrombosis. Materials and methods: Report of a patient presenting with acute dyspnoea and chest pain. Results: Using a combined medical team and imaging studies, pulmonary embolism and acute arterial thrombosis were diagnosed. The patient was treated medically and surgically. Conclusion: Physicians should be aware of the possibility of combined thrombosis and the diagnosis and management of the condition.. ...
Citicoline - Wikipedia, the free encyclopedia. Citicoline (CDP-choline) mechanisms of action and effects in. Citicoline Uses, Side Effects, Interactions and Warnings - WebMD. Citicoline neuroprotective mechanisms in cerebral ischemia. Citicoline Indication and Nursing Management Nursing Crib.
The hempcrete built in the Spring 2018 class failed to remain structurally sound after curing, so hempcrete from a previous semester was used instead. The recipe for this hempcrete is unknown, but a generic hempcrete recipe is as follows: Hempcrete Binder ...
Dr. Cameron Wright presents Bleeding and Thrombosis After PTE, recorded live at the UC San Diego Health Sulpizio Cardiovascular Center National Proceedings: CTEPH 2017., TV Network
Dr. Cameron Wright presents Bleeding and Thrombosis After PTE, recorded live at the UC San Diego Health Sulpizio Cardiovascular Center National Proceedings: CTEPH 2017., TV Network
Hi Are we able to predict the points of thrombosis in various conditions? Eg can we pinpoint the high risk plaque, other points with high risk for thrombos...
Looking for online definition of cervical part of internal carotid artery in the Medical Dictionary? cervical part of internal carotid artery explanation free. What is cervical part of internal carotid artery? Meaning of cervical part of internal carotid artery medical term. What does cervical part of internal carotid artery mean?
Stroke is the third-leading cause of death in America, and carotid artery stenosis-also known as carotid artery disease-is one of the leading risk factors for stroke, accounting for about 20 percent of strokes. To mark National Stroke Month in May, we asked University of Minnesota Health Neurosurgeon and Neurointerventionist Ramachandra Tummala, MD, to tell us five things we should know about carotid artery stenosis and its link to stroke risk.. Carotid stenosis occurs when buildup begins blocking blood flow.. Stenosis is a medical term for narrowing of blood vessels in the body due to a buildup of inflammatory substances and cholesterol deposits-called plaque. Two carotid arteries in the neck carry most of the blood flow from the heart to the brain. When stenosis occurs in these arteries it is known as carotid artery stenosis. Carotid artery stenosis can lead to a stroke.. Patients with carotid artery stenosis are at increased risk for a stroke, which can lead to disability or death. Sometimes, ...
TY - JOUR. T1 - Intrahepatic biliary strictures without hepatic artery thrombosis after liver transplantation. T2 - An analysis of 1,113 liver transplantations at a single center. AU - Nakamura, Noboru. AU - Nishida, Seigo. AU - Neff, Guy R.. AU - Vaidya, Anil. AU - Levi, David M.. AU - Kato, Tomoaki. AU - Ruiz, Phillip. AU - Tzakis, Andreas G.. AU - Madariaga, Juan R.. PY - 2005/2/27. Y1 - 2005/2/27. N2 - Background. Intrahepatic biliary strictures (IHBS) without hepatic artery thrombosis (HAT) is a serious complication and known to increase the risk of graft failure after liver transplantation. This manuscript describes the incidence, risk factors, clinical pictures, management, and outcomes. Methods. Between 1994 and 2002, 1,113 liver transplantations were performed in 974 adult patients. Data was retrospectively analyzed in terms of incidence, risk factors, clinical pictures (type of strictures), management (radiologic, surgical management), and outcomes. Results. Sixteen (1.4%) grafts had ...
Carotid artery disease is a disease in which a waxy substance called plaque builds up inside the arteries. You have two carotid arteries, one on each side of the neck which divide into the internal and external carotid arteries. The internal arteries supply blood to the brain and the external arteries supply blood to the face, scalp, and neck... Carotid artery disease is serious because it can cause a stroke if the plaque should build up to the point it cuts off blood supply to the brain, or the plaque ruptures and a blood clot forms in the artery cutting off blood supply to the brain.. Carotid artery disease causes over half the strokes that occur in the United States. Carotid artery disease may not have any symptoms until the arteries are severely narrowed or blocked. For some people, a stroke is the first sign of the disease.. ...
TY - JOUR. T1 - Endarterectomy for asymptomatic high-grade internal carotid artery stenosis-Does age alone really matter?. AU - Assadian, Afshin. AU - Taher, Fadi. AU - Assadian, Ojan. PY - 2016/9/20. Y1 - 2016/9/20. N2 - Background The aim of this retrospective observational study was to assess whether patients ≥ 75 years of age had a significantly inferior 5-year stroke free survival rate compared to patients ,75 years of age after carotid endarterectomy under regional anesthesia. Methods All consecutive patients with asymptomatic high-grade internal carotid artery (ICA) stenosis operated on from January 1997 to December 1999. Of 273 consecutive patients with asymptomatic carotid artery stenosis, follow up was complete for 253 patients. Results Of 253 patients, 152 were younger and 102 older than 75 years at surgery (65 ± 8 years (range 43-74) and 79 ± 4 years (range 75-90); P , 0.001), respectively. Perioperatively, 4 patient developed stoke (1.6%), 2 in each group (1.3% and 1.6%, ...
This lateral view from an internal carotid artery angiogram demonstrates the origin of the ascending pharyngeal artery from the cervical internal carotid artery, which is an unusual but normal variant of angiographic anatomy. Normally, the ascending pharyngeal artery arising from the proximal external carotid artery. - Stock Image C007/5818
Disease of the carotid artery is related to, in large part, the amount of atherosclerosis (or plaque) that is present in one of the main arteries to the brain-the Internal Carotid Artery (ICA. )Typically, the more plaque that is present, the narrower the diameter of the internal portion of the artery is that is delivering blood to the brain. One potential cause of stroke is the lack of enough blood flow to the brain that may be reduced as the inner diameter of the ICA get smaller. Alternatively, a piece of the plaque in the ICA could break away and travel to the brain lodging in a small artery producing a stroke by restricting blood flow (and oxygen) to a particular area of the brain.. While degree of narrowing within the carotid artery is a factor in determining whether intervention is required, the presence of symptoms related specifically to the carotid artery in question is another important factor to be considered. People may have a significant degree of narrowing of their ICA-in fact, it ...
Radcliffe Vascular peer-reviewed articles on carotid artery stenting, carotid artery endarterectomy, carotid artery disease, carotid artery stenosis, carotid
Find the best carotid artery disease doctors in Kolkata. Get guidance from medical experts to select carotid artery disease specialist in Kolkata from trusted hospitals - credihealth.com
In the nanoscale assembly-based design of antithrombotic agents, poly-alpha,beta-DL-aspartyl-L-arginine (MW: 20 741) was prepared. from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-arginine. In the pH environments corresponding to the stomach (pH 1.2), intestinal tract (pH 7.6), blood and tissue fluids (pH 7.4) 4.8 x 10(4,2,-4,-6,-8) nM of poly-alpha,beta-DL-aspartyl-L-arginine assembled to form diverse nano-species. The sizes of the smallest nanoparticle, nanobell and nanomango were less than 100 nm. At the oral doses of 0.72, 1.44 and 2.89 mu mol kg(-1), poly-alpha,beta-DL-aspartyl-L-arginine dose-dependently inhibited the ex vivo platelet aggregation and the in vivo thrombosis of the treated rats. By assembling to form diverse nano-species, the absorption of oral poly-alpha,beta-DL-aspartyl-L-arginine in the stomach and intestinal tract could be assisted. ...
Thrombosis of a cerebral artery. The cerebral thrombosis (obstruction of a cerebral artery by thrombus) or cerebral embolism (obstruction of a cerebral artery by an element coming from another part of the body) leads to an ischemia (reduction of the blood intake), verily a cerebral infarction (death or necrosis of the unirrigated region of the brain). - Stock Image C006/3975
Red blood cells (RBCs) influence rheology, and release ADP, ATP, and nitric oxide, suggesting a role for RBCs in hemostasis and thrombosis. Here, we provide evidence for a significant contribution of RBCs to thrombus formation. Anemic mice showed enhanced occlusion times upon injury of the carotid artery. A small population of RBCs was located to platelet thrombi and enhanced platelet activation by a direct cell contact via the FasL/FasR (CD95) pathway known to induce apoptosis. Activation of platelets in the presence of RBCs led to platelet FasL exposure that activated FasR on RBCs responsible for externalization of phosphatidylserine (PS) on the RBC membrane. Inhibition or genetic deletion of either FasL or FasR resulted in reduced PS exposure of RBCs and platelets, decreased thrombin generation, and reduced thrombus formation in vitro and protection against arterial thrombosis in vivo. Direct cell contacts between platelets and RBCs via FasL/FasR were shown after ligation of the inferior vena ...
The external carotid arteries supply oxygenated blood to the head region. There is one external carotid artery on the right side of the neck and one on the left side of the neck.
Details of the image Occluded distal left M1 internal carotid artery with cerebral ischaemia Modality: CT (RAPID Color MTT [s])
Milano, 11 Marzo 2008 Functional Data Analysis of the Geometrical Features of the Internal Carotid Artery Laura Maria SANGALLI Piercesare SECCHI Simone VANTINI Alessandro VENEZIANI The ANEURISK Project
Carotid artery disease is when the carotid arteries, which provide the main blood supply to your brain, become narrow or blocked. Carotid disease is very highly associated with stroke.
... Artery: Common carotid artery Schematic of the proximal aorta and its branches. Arteries of the neck. The internal carotid arteries arise
The internal carotid artery is a major paired artery, one on each side of the head and neck, in human anatomy. They arise from the common carotid arteries where these bifurcate into the internal and external carotid arteries at cervical vertebral level 3 or 4; the internal carotid artery supplies the brain, while the external carotid nourishes other portions of the head, such as face, scalp, skull, and meninges. Terminologia Anatomica in 1998 subdivided the artery into four parts: "cervical", "petrous", "cavernous", and "cerebral". However, in clinical settings, the classification system of the internal carotid artery usually follows the 1996 recommendations by Bouthillier, describing seven anatomical segments of the internal carotid artery, each with a corresponding alphanumeric identifier-C1 cervical, C2 petrous, C3 lacerum, C4 cavernous, C5 clinoid, C6 ophthalmic, and C7 communicating. The Bouthillier nomenclature remains in widespread use by neurosurgeons, neuroradiologists and neurologists. ...
Transendothelial migration of ferric ion in FeCl3 injured murine common carotid artery. Thrombosis Research 118 (2): 275-280. ...
"Transendothelial migration of ferric ion in FeCl3 injured murine common carotid artery". Thrombosis Research. 118 (2): 275-280 ... Used in an animal thrombosis model. Used in energy storage systems Historically it was used to make direct positive blueprints ...
"Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness : The Atherosclerosis Risk in Communities ( ... ARIC) Study". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (11): 1816-22. doi:10.1161/hq1101.097803. Elter, John R.; ...
With Maria Dicicco, RVT, he pioneered the measurement of total plaque area (TPA) in a patient's carotid artery using ultrasound ... Recently, he has received the Research Excellence Award from the Canadian Society for Atherosclerosis, Thrombosis and Vascular ... for research and for management of patients with carotid artery disease. (.). This has evolved to the use of 3-D plaque volume ... Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy Stroke. 2002;33:2916-2922 Stroke 1986; 17( ...
Two types of thrombosis can cause stroke: Large vessel disease involves the common and internal carotid arteries, the vertebral ... tightening of the artery), aortic, carotid or vertebral artery dissection, various inflammatory diseases of the blood vessel ... middle cerebral artery, stem, and arteries arising from the distal vertebral and basilar artery. Diseases that may form thrombi ... thrombosis or embolism due to atherosclerosis of a large artery, (2) an embolism originating in the heart, (3) complete ...
Dissections within the carotid arteries or vertebral arteries may compromise blood flow to the brain due to thrombosis, and ... The common carotid artery divides into the internal and the external carotid arteries. The internal carotid artery becomes the ... From the basilar artery are two posterior cerebral arteries. Branches of the basilar and PCA supply the occipital lobe, brain ... The carotid arteries cover the majority of the cerebrum. ... Arteries supplying oxygen and nutrients to the brain are often ...
Carotid artery disease Arterial spasm (TIA) Diabetes mellitus Collagen diseases Venous occlusive disease Thrombosis Use of ... Emboli and thrombi Central retinal artery occlusion Cardiac myxoma Cranial arteritis Sickle cell attack Occlusive vascular ...
... carotid artery diseases MeSH C10.228.140.300.200.331 --- carotid artery thrombosis MeSH C10.228.140.300.200.345 --- carotid ... carotid artery injuries MeSH C10.900.250.300.300 --- carotid artery, internal, dissection MeSH C10.900.250.300.400 --- carotid- ... carotid artery injuries MeSH C10.228.140.300.350.500.300 --- carotid artery, internal, dissection MeSH C10.228.140.300.350.500. ... carotid artery, internal, dissection MeSH C10.228.140.300.200.360 --- carotid stenosis MeSH C10.228.140.300.200.490 --- carotid ...
... and to assess ophthalmic artery reversal of flow indicating a thrombosis of the carotid artery (1969). Maroon et al. published ... Maroon, J. C.; Campbell, R. L.; Dyken, M. L. (1970-04-01). "Internal carotid artery occlusion diagnosed by Doppler ultrasound ... they published the case of Golfer's Stroke from Vertebral Artery Dissection. Further groundbreaking publications include the ... golf-induced stroke from vertebral artery dissection". Surgical Neurology. 67 (2): 163-168; discussion 168. doi:10.1016/j. ...
With Decreased Blood Pressure but Not With Improved Brachial Artery Endothelium-Dependent Vasodilation or Carotid Artery ... Stiffness: a 2-Year, Randomized, Placebo-Controlled Trial". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (12): 2072- ... and there was no effect on common carotid artery stiffness. Blood pressure Mean arterial pressure Cold pressor test ... an extra path for blood to travel from a high pressure artery to a low pressure vein without the gradient of a capillary bed), ...
... angiitis Carotid or vertebral artery pain Headache or facial or neck pain attributed to arterial dissection Post-endarterectomy ... attributed to intracranial endovascular procedures Angiography headache Headache attributed to cerebral venous thrombosis (CVT ...
... a migraine attack and be relieved afterwards Carotid artery dissection/carotid artery aneurysm Cavernous sinus thrombosis ... Postganglionic lesions at the level of the internal carotid artery (e.g. a tumor in the cavernous sinus or a carotid artery ...
An embolus lodging in the brain from either the heart or a carotid artery will most likely be the cause of a stroke due to ... deep vein thrombosis. Arterial embolism can cause occlusion in any part of the body. It is a major cause of infarction, tissue ... Embolism can be classified as to where it enters the circulation either in arteries or in veins. Arterial embolism are those ... in the sense that the clot follows the pulmonary artery carrying deoxygenated blood away from the heart. However, pulmonary ...
Orbital cellulitis Internal carotid artery aneurysm Stroke Migraine headache Allergic blepharitis Thyroid exophthalmos Brain ... Findings may include deformity of the internal carotid artery within the cavernous sinus, and an obvious signal hyperintensity ... "Cavernous sinus thrombosis - NHS Choices". www.nhs.uk. NHS Choices. Retrieved 27 May 2016. "Cavernous sinus thrombosis: ... Cavernous sinus thrombosis (CST) is the formation of a blood clot within the cavernous sinus, a cavity at the base of the brain ...
These vessels are the ACA (anterior cerebral artery), MCA (middle cerebral artery), and ICA (internal carotid artery). The ... Blood flow is blocked by the constriction, and also by blood clots (thrombosis). A collateral circulation develops around the ... such as the external carotid artery or the superficial temporal artery to replace its circulation. The arteries are either sewn ... branches of the internal carotid artery inside the skull. When the internal carotid artery becomes completely blocked, the fine ...
The syndrome has been associated with occlusion of the common carotid artery, internal carotid artery, and less frequently the ... High clinical suspicion should be kept for painless vision loss in patients with atherosclerosis, deep venous thrombosis, ... The retinal arteries may show spontaneous pulsations. If carotid occlusive disease results in ophthalmic artery occlusion, ... Retinal artery occlusion (such as central retinal artery occlusion or branch retinal artery occlusion) leads to rapid death of ...
... thromboses, or fistulas. Of these, 76% had intimal dissections, pseudoaneurysms, or a combination of the two. The probable ... The incidence of spontaneous carotid artery dissection is low, and incidence rates for internal carotid artery dissection have ... Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing blood to the head and brain ... Treatments include observation, anticoagulation, stent implantation and carotid artery ligation. 70% of patients with carotid ...
Carotid ultrasonography is often used to screen for carotid artery stenosis, as it is more readily available. However, all of ... In-situ thrombosis, an obstruction that forms directly in the cerebral vasculature unlike the remote embolism spoken about ... Confirming a diagnosis of carotid artery stenosis is important because the treatment for this condition, carotid endarterectomy ... Another common culprit of TIA is an atherosclerotic plaque located in the common carotid artery, typically by the bifurcation ...
... usually at the carotid artery) for a period of 10 seconds. These possible causes are remembered as the 6 Hs and the 6 Ts. See ... Cardiac Tamponade Tension pneumothorax Thrombosis (e.g., myocardial infarction, pulmonary embolism) Tachycardia Trauma (e.g., ...
... carotid artery diseases MeSH C14.907.253.123.331 --- carotid artery thrombosis MeSH C14.907.253.123.345 --- carotid artery ... intracranial embolism and thrombosis MeSH C14.907.355.350.850.213.206 --- carotid artery thrombosis MeSH C14.907.355.350. ... intracranial embolism and thrombosis MeSH C14.907.355.830.850.213.206 --- carotid artery thrombosis MeSH C14.907.355.830. ... intracranial embolism and thrombosis MeSH C14.907.253.378.206 --- carotid artery thrombosis MeSH C14.907.253.378.300 --- ...
Dissection of carotid artery (443.22) Dissection of iliac artery (443.23) Dissection of renal artery (443.24) Dissection of ... 452) Portal vein thrombosis (453) Other venous embolism and thrombosis (453.4) Deep vein thrombosis, unspec. (453.41) Deep vein ... Occlusion of cerebral arteries (434.0) Cerebral thrombosis (434.00) Cerebral thrombosis without cerebral infarction (434.01) ... Occlusion and stenosis of basilar artery (433.1) Occlusion and stenosis of carotid artery (433.2) Occlusion and stenosis of ...
CVCs can be mistakenly placed in an artery during insertion (for example, the carotid artery or vertebral artery when placed in ... For patients with central venous access, a wide variation in the incidence of vein thrombosis (1 to 66 percent) is reported and ... Bleeding can range from localized hematoma (bruise) to hemorrhage (profuse bleeding). Thrombosis The use of central venous ... "Catheter-related upper extremity venous thrombosis". uptodate.com. Retrieved 11 February 2016. ...
Coronary artery disease Acute myocardial infarction Peripheral arterial disease Carotid disease Deep venous thrombosis Biliary ... Deep Vein Thrombosis and Nutritional Insufficiency businesses for $6.1 billion in cash. On October 31, 2016 Cardinal Health ... which enables direct access to the radial artery with a guiding catheter and eliminates the need for an introducer sheath, ... Balloon-Expandable Stent for coronary artery applications. 1996 Cordis joins the Johnson & Johnson interventional business ...
The other type, carotid artery dissection, involves the carotid arteries. Vertebral artery dissection is further classified as ... From various lines of evidence, it appears that thrombosis and embolism is the predominant problem.[1] ... Vertebral artery dissection is less common than carotid artery dissection (dissection of the large arteries in the front of the ... or for symptoms of carotid artery dissection to occur at the same time as those of vertebral artery dissection.[2] Some give a ...
... may occur in veins (venous thrombosis) or in arteries (arterial thrombosis). Venous thrombosis leads to congestion ... The former affects vessels such as the internal carotids, vertebral and the circle of Willis. The latter can affect smaller ... Arterial thrombosis[edit]. Arterial thrombosis is the formation of a thrombus within an artery. In most cases, arterial ... Renal vein thrombosis[edit]. Main article: Renal vein thrombosis. Renal vein thrombosis is the obstruction of the renal vein by ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Thrombosis may occur in veins (venous thrombosis) or in arteries. Venous thrombosis leads to congestion of the affected part of ... Arterial thrombosis[edit]. Arterial thrombosis is the formation of a thrombus within an artery. In most cases, arterial ... Renal vein thrombosis[edit]. Main article: Renal vein thrombosis. Renal vein thrombosis is the obstruction of the renal vein by ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Venous thrombosis /. Thrombophlebitis. *primarily lower limb *Deep vein thrombosis. *abdomen *Hepatic veno-occlusive disease ... "Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population". Int ... It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ...
CVCs can be mistakenly placed in an artery during insertion (for example, the carotid artery or vertebral artery when placed in ... CVCs are a risk factor for forming blood clots (venous thrombosis) including upper extremity deep vein thrombosis. It is ... Rosendaal, F. R.; Reitsma, P. H. (July 2009). "Genetics of venous thrombosis". Journal of Thrombosis and Haemostasis. 7 suppl 1 ... The color of the blood and the rate of its flow help distinguish it from arterial blood (suggesting that an artery has been ...
In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region of the carotid bifurcation ... Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis.. R N ... In contrast, thrombosis of the carotid artery was associated with neurophysiological deterioration in six of the nine dogs ... In this model, the administration of 1 mg/kg i.v. SK&F 106760 prevented thrombosis of the stenotic carotid artery. Consequently ...
This is why the term carotid artery stenosis refers to internal carotid artery stenosis. But common carotid artery stenosis has ... Diagnosis of common carotid artery stenosis. Common carotid artery stenosis is often diagnosed when actually looking for ... Common carotid artery stenosis is less common than internal carotid artery stenosis. Surprisingly, a in a study that examined ... Carotid artery imaging - An article about the various techniques used for evaluation of the internal carotid artery. Includes ...
Thrombosis of Internal Carotid Artery Treated by Arterial Surgery Br Med J 1957; 2 :264 ... Thrombosis of Internal Carotid Artery Treated by Arterial Surgery. Br Med J 1957; 2 doi: https://doi.org/10.1136/bmj.2.5039.264 ... Thrombosis of Internal.... *Thrombosis of Internal Carotid Artery Treated by Arterial Surgery ...
Abstract 421: Biomarkers of Atherosclerotic Plaque Instability in Carotid Artery Stenosis Daniel J Lee, Sean J Hislop, Adam J ... Collagen Alignment Correlates with Differential Biaxial Stiffness in Nonhuman Primate Carotid and Femoral Arteries Roy Wang, ... Abstract 110: Carotid Plaque Instability is Associated with an Increase in the Serum Ratio of circularRNA-284 to microRNA-221 ... Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38:206-217, originally published November 9, 2017 ...
The carotid artery was divided into 3 segments: common carotid artery; bifurcation; and internal carotid artery. Remodeling ... The carotid artery provides an opportunity to examine these variations because of the unique geometry of the carotid bulb. This ... Carotid Artery Remodeling Is Segment SpecificHighlights. Hiroko Watase, Jie Sun, Daniel S. Hippe, Niranjan Balu, Feiyu Li, ... Carotid Artery Remodeling Is Segment SpecificHighlights. Hiroko Watase, Jie Sun, Daniel S. Hippe, Niranjan Balu, Feiyu Li, ...
Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis assessed as ... reduction in thrombosis-induced occlusion by measuring thrombus weight at 10 mg/kg, po dosed 1 to 2 hrs before test. ...
... by concentration of these carriers in a particular part of the arterial bed if a miniature magnet was placed outside the artery ... Conservative treatment of postoperative thrombosis could become much more effective and harmless if a drug could be supplied ... Local thrombosis prevention in the dogs carotid artery by magnetic targeting of aspirin-loading erythrocytes. @article{ ... Orekhov2004LocalTP, title={Local thrombosis prevention in the dogs carotid artery by magnetic targeting of aspirin-loading ...
Carotid thrombosis. Care must be exercised in cases of carotid thrombosis. Very slow flow rates may be missed if the timing of ... carotid bulb). ec = external carotid artery; f = facial artery; l = lingual artery; ic = internal carotid artery; im = internal ... carotid bulb). ec = external carotid artery; f = facial artery; l = lingual artery; ic = internal carotid artery; im = internal ... CCA = common carotid artery, D = narrowed diameter, ECA = external carotid artery, ICA = internal carotid artery, and N = ...
Spontaneous thrombosis of internal carotid artery; case report. Indian Journal of Medical Sciences. 1957 May; 11(5): 337-40. ...
Carotid artery surgery is a procedure to restore proper blood flow to the brain. ... Deep Venous Thrombosis. Dr. Tej Singh discusses Deep Venous Thrombosis.. Deep Venous Thrombosis. ... Carotid endarterectomy; CAS surgery; Carotid artery stenosis - surgery; Endarterectomy - carotid artery Description. During ... The side your blocked carotid artery is on faces up. *The surgeon makes a cut (incision) on your neck over your carotid artery ...
Right carotid arteries were injured for 20 minutes with a 24-mm2 piece of Bio-Rad Trans-Blot paper soaked in 20% FeCl3. ... Guinea Pig Carotid Artery Injury Model. Two- to 4-week-old Hartley guinea pigs (weight, 170 to 260 g) were purchased from ... B, Representative carotid artery occlusion tracings for vehicle vs bivalirudin plus P4pal-i1-treated guinea pigs from A. ... Figure 4. Combination of bivalirudin plus a PAR4 pepducin or PAR1 and PAR4 blockade inhibits occlusion of carotid arteries in ...
I63.03 Cerebral infarction due to thrombosis of carotid artery NON-BILLABLE * * BILLABLE I63.031 Cerebral infarction due to ... BILLABLE I63.032 Cerebral infarction due to thrombosis of left carotid artery * BILLABLE I63.039 Cerebral infarction due to ... Cerebral infarction due to thrombosis of carotid artery NON-BILLABLE Non-Billable Code Non-Billable means the code is not ... ICD-10-CM Alphabetical Index References for I63.03 - Cerebral infarction due to thrombosis of carotid artery The ICD-10-CM ...
Inhibition of arterial thrombosis by recombinant annexin V in a rabbit carotid artery injury model. Circulation. 1997;96: 2339- ... In this mouse thrombosis model, rose bengal dye in the lumen of the carotid artery was excited by transillumination with a ... Photochemically induced carotid artery thrombosis in mice. The protocol of Eitzman et al33 was followed with slight ... Prolongation of time to occlusion by ANV and TAP-ANV in a photochemically induced carotid artery thrombosis model in mice. ...
Risk and prevention of deep venous thrombosis. Take Quiz. Antithrombotics in venous thromboembolism. Take Quiz. ... AHA/ACC Guidelines: Lower-extremity peripheral artery disease treatment. Take Quiz. AABB Guidelines: Red blood cell transfusion ... Is coronary artery calcium a biomarker for coronary heart disease?. Take Quiz. ... Is coronary artery calcium a biomarker for coronary heart disease?. Take Quiz. ...
Murine carotid artery thrombosis model. The time to occlusion (TTO) of the ferric-chloride treated carotid artery was assessed ... 15], who noted a significant increase in the TTO in a rat carotid artery model in which thrombosis was initiated by application ... Time to occlusion of murine ferric chloride-treated carotid arteries. The time to occlusion (TTO) of surgically exposed carotid ... the carotid artery was exposed surgically, and thrombosis was induced by topical application of a 1 mm2 patch of Whatman paper ...
Carotid artery disease. Chronic venous insufficiency. Deep vein thrombosis. Peripheral vascular disease. Varicose veins. As ...
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury, Performing Permanent ... carotid arteries include Mechanical Testing of Mouse Carotid Arteries: from Newborn to Adult, Assessing Collagen and ... A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts, Anatomy of the ... In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium, Effects of Blast-induced Neurotrauma on Pressurized ...
In vivo model of arterial thrombosis by carotid artery ligation.. As a model of arterial thrombosis, carotid injury was induced ... Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J. Surg. Res. 108:212-221. doi:10.1006/ ... deep vein thrombosis. GP. glycoprotein. IVC. inferior vena cava. MPO. myeloperoxidase. NE. neutrophil elastase. NET. neutrophil ... Deep venous thrombosis of the legs after strokes: Part 2-Natural history. BMJ. 1:1181-1183. doi:10.1136/bmj.1.6019.1181. ...
... peripheral artery disease (PAD), varicose veins, and more. ... See pictures of vein and artery problems and learn about the ... causes and symptoms of conditions like coronary artery disease, ... Carotid Artery Disease. The carotid arteries run along either ... "What Are the Signs and Symptoms of Carotid Artery Disease?" "What Causes Deep Vein Thrombosis?" "What Causes Varicose Veins?" " ... If you have carotid artery disease, plaque builds up and narrows these arteries, so less blood gets through. A piece of plaque ...
Ellie Choi, DO, a highly rated Neurology Specialist in Kirkland, WA specializing in Transient Ischemic Attack (TIA), Carotid ... Carotid Artery Disease. *Cerebral Artery Thrombosis. *Cerebral Hemorrhage. *Cerebrovascular Disease. *EEG (Electroencephalogram ...
Carotid Artery Disease. *Cerebral Artery Thrombosis. *Chest Pain. *Chronic Deep Vein Thrombosis (DVT) ... Patients with a history of diabetes, smoking, coronary artery disease, high blood pressure, high cholesterol and obesity and ...
Coronary Artery Disease. Carotid Artery Diseases. Pathologic Processes. Embolism and Thrombosis. Vascular Diseases. ... Cardiovascular Diseases Carotid Artery Diseases Arrhythmia Myocardial Ischemia Thrombosis Heart Diseases Atherosclerosis ... Holter monitoring and ultrasonography of the carotid arteries were performed in Cohort II only. Psychosocial measures included ... Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med. 2001 Jan 2;134(1): ...
Carotid artery disease. * Deep venous thrombosis. * Varicose veins. Head & Neck Surgery:. * Salivary gland tumours. * Carcinoma ...
Embolism and Thrombosis. Aortic Diseases. Carotid Artery Diseases. Cerebrovascular Disorders. Brain Diseases. Central Nervous ... Thrombosis. Aortic Aneurysm. Arteriosclerosis. Carotid Stenosis. Aortic Aneurysm, Abdominal. Heart Diseases. Cardiovascular ... Coronary Artery Disease. Myocardial Ischemia. Coronary Disease. Aneurysm. ...
Deep vein thrombosis. *Carotid artery disease. *Peripheral vascular disease. *Aortic aneurysms. *Varicose veins and venous ... Jones, G.T., van Rij, A.M., Hill, G.B., Wilkins, G.T., & Williams, M.J.A. (2008). Common carotid intimal-medial thickness is ...
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts. (wikipedia.org)
  • Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. (ahajournals.org)
  • In the setting of intracranial large artery occlusion (iLAO) this treatment is associated with low rates of recanalization and high rates of neurological morbidity and severe disability. (hindawi.com)
  • Because coagulation factor XI (FXI) is more involved in thrombosis than hemostasis, we hypothesized that making HV3 activity FXIa-dependent would also improve HV3's potential therapeutic profile. (springer.com)
  • Although duplex imaging helps in the detection of carotid lesions in asymptomatic patients, the cost and risk associated with potentially unnecessary follow-up testing and the risk of unnecessary surgical procedures are arguments againt the wider application of carotid sonography in asymptomatic indivduals. (medscape.com)
  • Arterial thrombosis is the leading cause of mortality in Western nations and remains a prevalent, postintervention complication in patients undergoing percutaneous coronary interventions. (ahajournals.org)
  • The medications used in the treatment of patients with basilar artery thrombosis include thrombolytic agents, anticoagulants, antihypertensive agents, and antiplatelet agents. (medscape.com)
  • We consecutively recruited 481 patients with cerebral arterial thrombosis and 538 healthy controls. (cdc.gov)
  • An estimated 0.67% of patients admitted to the hospital after major motor vehicle accidents were found to have blunt carotid injury, including intimal dissections, pseudoaneurysms, thromboses, or fistulas. (thefullwiki.org)
  • However, multiple artery stenotic lesions affecting the blood supply to a a specific site will produce signs and symptoms sooner and impair recovery. (healthhype.com)