Carotid Artery Injuries: Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)Carotid Arteries: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Carotid Artery Thrombosis: Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.Carotid Artery, Common: The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.Neck Injuries: General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.Tunica Intima: The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.Wounds, Nonpenetrating: Injuries caused by impact with a blunt object where there is no penetration of the skin.Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)Neointima: The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Carotid Artery, External: Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.Endarterectomy, Carotid: The excision of the thickened, atheromatous tunica intima of a carotid artery.Vascular System Injuries: Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.Arteries: The vessels carrying blood away from the heart.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Wounds, Stab: Penetrating wounds caused by a pointed object.Vertebral Artery: The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Wounds, Penetrating: Wounds caused by objects penetrating the skin.Carotid Artery, Internal, Dissection: The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Carotid Body: A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.Subclavian Artery: Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.Carotid Sinus: The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Angiography: Radiography of blood vessels after injection of a contrast medium.Iatrogenic Disease: Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.Wounds, Gunshot: Disruption of structural continuity of the body as a result of the discharge of firearms.Iliac Artery: Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cerebral Arteries: The arterial blood vessels supplying the CEREBRUM.Tunica Media: The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Carotid Intima-Media Thickness: A measurement of the thickness of the carotid artery walls. It is measured by B-mode ULTRASONOGRAPHY and is used as a surrogate marker for ATHEROSCLEROSIS.Axillary Artery: The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.Aneurysm, False: Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.Brachiocephalic Trunk: The first and largest artery branching from the aortic arch. It distributes blood to the right side of the head and neck and to the right arm.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Basilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Ultrasonography, Doppler, Duplex: Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Mesenteric Arteries: Arteries which arise from the abdominal aorta and distribute to most of the intestines.Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)Arteriovenous Fistula: An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.Magnetic Resonance Angiography: Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.Athletic Injuries: Injuries incurred during participation in competitive or non-competitive sports.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Endarterectomy: Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Angiography, Digital Subtraction: A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Angioplasty: Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.Intraoperative Complications: Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Coronary Vessels: The veins and arteries of the HEART.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Popliteal Artery: The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.Radial Artery: The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.Cerebrovascular Trauma: Penetrating and nonpenetrating traumatic injuries to an extracranial or intracranial blood vessel that supplies the brain. This includes the CAROTID ARTERIES; VERTEBRAL ARTERIES; MENINGEAL ARTERIES; CEREBRAL ARTERIES; veins, and venous sinuses.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Brachial Artery: The continuation of the axillary artery; it branches into the radial and ulnar arteries.Hemostatic Techniques: Techniques for controlling bleeding.Accidents, Traffic: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Middle Cerebral Artery: The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Ophthalmic Artery: Artery originating from the internal carotid artery and distributing to the eye, orbit and adjacent facial structures.Multiple Trauma: Multiple physical insults or injuries occurring simultaneously.Myocytes, Smooth Muscle: Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).Mammary Arteries: Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.Aneurysm: Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.Ultrasonography: The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.Intracranial Embolism: Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Ultrasonography, Doppler, Color: Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Injury Severity Score: An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).Ligation: Application of a ligature to tie a vessel or strangulate a part.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Intracranial Arteriosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.Ultrasonography, Doppler, Transcranial: A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Circle of Willis: A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.Hematoma: A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.Leg Injuries: General or unspecified injuries involving the leg.Carotid Body Tumor: Benign paraganglioma at the bifurcation of the COMMON CAROTID ARTERIES. It can encroach on the parapharyngeal space and produce dysphagia, pain, and cranial nerve palsies.Lung Injury: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.Temporal Arteries: Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Intracranial Embolism and Thrombosis: Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.Cerebral Revascularization: Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Mice, Inbred C57BLAmaurosis Fugax: Transient complete or partial monocular blindness due to retinal ischemia. This may be caused by emboli from the CAROTID ARTERY (usually in association with CAROTID STENOSIS) and other locations that enter the central RETINAL ARTERY. (From Adams et al., Principles of Neurology, 6th ed, p245)Splenic Artery: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.Ultrasonography, Doppler: Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)Constriction, Pathologic: The condition of an anatomical structure's being constricted beyond normal dimensions.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Retinal Artery Occlusion: Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.Embolization, Therapeutic: A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.Cavernous Sinus: An irregularly shaped venous space in the dura mater at either side of the sphenoid bone.Hepatic Artery: A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Jugular Veins: Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Eye Injuries: Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.Celiac Artery: The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Cervical Vertebrae: The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Mesenteric Artery, Superior: A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.Plaque, Atherosclerotic: Lesions formed within the walls of ARTERIES.Anticoagulants: Agents that prevent clotting.Cranial Nerve Injuries: Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.Calcinosis: Pathologic deposition of calcium salts in tissues.

Endothelial implants inhibit intimal hyperplasia after porcine angioplasty. (1/784)

The perivascular implantation of tissue-engineered endothelial cells around injured arteries offers an opportunity to study fundamental vascular physiology as well as restore and improve tissue function. Cell source is an important issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the clinical applications of tissue-engineered grafts. We investigated the biological and immunological responses to endothelial cell xenografts and allografts in pigs 4 weeks after angioplasty of the carotid arteries. Porcine or bovine aortic endothelial cells were cultured within Gelfoam matrices and implanted in the perivascular space of 42 injured arteries. Both porcine and bovine endothelial cell grafts reduced the restenosis index compared with control by 54% and 46%, respectively. Perivascular heparin release devices, formulated to release heparin at twice the rate of release of heparan sulfate proteoglycan from endothelial cell implants, produced no significant reduction in the restenosis index. Endothelial cell implants also reduced occlusive thrombosis compared with control and heparin release devices. Host immune responses to endothelial implants were investigated by immunohistochemical examination of explanted devices and by immunocytochemistry of serum samples. The bovine cell grafts displayed infiltration of leukocytes, consisting primarily of lymphocytes, and caused an increase in antibodies detected in serum samples. Reduced cellular infiltration and no humoral response were detected in animals that received allografts. Despite the difference in immune response, the biological effects of xenografts or allografts did not differ significantly.  (+info)

Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. (2/784)

Prostacyclin (PGI2), a metabolite of arachidonic acid, has the vasoprotective effects of vasodilation, anti-platelet aggregation, and inhibition of smooth muscle cell proliferation. We hypothesized that an overexpression of endogenous PGI2 may accelerate the recovery from endothelial damage and inhibit neointimal formation in the injured artery. To test this hypothesis, we investigated in vivo transfer of the PGI2 synthase (PCS) gene into balloon-injured rat carotid arteries by a nonviral lipotransfection method. Seven days after transfection, a significant regeneration of endothelium was observed in the arteries transfected with a plasmid carrying the rat PCS gene (pCMV-PCS), but little regeneration was seen in those with the control plasmid carrying the lacZ gene (pCMV-lacZ) (percent luminal circumference lined by newly regenerated endothelium: 87. 1+/-6.9% in pCMV-PCS-transfected vessels and 6.9+/-0.2% in pCMV-lacZ vessels, P<0.001). BrdU staining of arterial segments demonstrated a significantly lower incorporation in pCMV-PCS-transfected vessels (7. 5+/-0.3% positive nuclei in vessel cells) than in pCMV-lacZ (50. 7+/-9.6%, P<0.01). Moreover, 2 weeks after transfection, the PCS gene transfer resulted in a significant inhibition of neointimal formation (88% reduction in ratio of intima/media areas), whereas medial area was similar among the groups. Arterial segments transfected with pCMV-PCS produced significantly higher levels of 6-keto-PGF1alpha, the main metabolite of PGI2, compared with the segments transfected with pCMV-lacZ (10.2+/-0.55 and 2.1+/-0.32 ng/mg tissue for pCMV-PCS and pCMV-placZ, P<0.001). In conclusion, this study demonstrated that an in vivo PCS gene transfer increased the production of PGI2 and markedly inhibited neointimal formation with accelerated reendothelialization in rat carotid arteries after balloon injury.  (+info)

Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation. (3/784)

The aim of this study was to evaluate whether vascular remodeling and neointimal thickening occur after balloon dilatation of the nonatherosclerotic rabbit carotid artery, and whether both processes are influenced by continuous perivascular delivery of L-arginine or the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). In the first experiment, histological and morphometric evaluation of arteries was performed at different time points after balloon dilatation: 10 minutes (n=7), and 1 (n=7), 2 (n=9), 3 (n=20), or 10 (n=5) weeks. Neointimal thickening progressively contributed to luminal narrowing for at least 10 weeks after angioplasty. During the first 2 weeks after dilatation, a significant decrease of the total vessel area was measured. Ten weeks after dilatation, both the neointimal and total vessel area were increased without further changing of the luminal area. In the second experiment, endothelial injured rabbits were randomly assigned to receive 2 weeks of continuous local perivascular physiological salt solution (n=6), L-arginine (n=8), or L-NAME (n=7), starting immediately after balloon dilatation (ie, local drug delivery during the first phase of the biphasic vascular remodeling process). Perivascular L-arginine delivery significantly reduced the neointimal area, despite an increased number of neointimal Ki-67-positive smooth muscle cells. Both the luminal area and total vessel area were significantly increased. Serum L-arginine levels remained unchanged. L-NAME administration had no effect on the neointimal area, nor on the luminal and total vessel area. Neointimal formation and biphasic vascular remodeling occur after experimental balloon dilatation of the nonatherosclerotic rabbit carotid artery, and can be influenced by continuous local perivascular delivery of L-arginine.  (+info)

TIMP-4 is regulated by vascular injury in rats. (4/784)

The role of basement membrane-degrading matrix metalloproteinases (MMPs) in enabling vascular smooth muscle cell migration after vascular injury has been established in several animal models. In contrast, the role of their native inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), has remained unproven despite frequent coregulation of MMPs and TIMPs in other disease states. We have investigated the time course of expression and localization of TIMP-4 in rat carotid arteries 6 hours, 24 hours, 3 days, 7 days, and 14 days after balloon injury by in situ hybridization, immunohistochemistry, and Western blot analysis. TIMP-4 protein was present in the adventitia of injured carotid arteries from 24 hours after injury. At 7 and 14 days after injury, widespread immunostaining for TIMP-4 was observed throughout the neointima, media, and adventitia of injured arteries. Western blot analysis confirmed the quantitative increase in TIMP-4 protein at 7 and 14 days. In situ hybridization detected increased expression of TIMP-4 as early as 24 hours after injury and a marked induction in neointimal cells 7 days after injury. We then studied the effect of TIMP-4 protein on the migration of smooth muscle cells through a matrix-coated membrane in vitro and demonstrated a 53% reduction in invasion of rat vascular smooth muscle cells. These data and the temporal relationship between the upregulation of TIMP-4, its accumulation, and the onset of collagen deposition suggest an important role for TIMP-4 in the proteolytic balance of the vasculature controlling both smooth muscle migration and collagen accumulation in the injured arterial wall.  (+info)

The role of alpha and beta platelet-derived growth factor receptor in the vascular response to injury in nonhuman primates. (5/784)

Restenosis remains a significant clinical problem associated with mechanical interventional procedures for arterial revascularization or repair, including coronary angioplasty and stenting. Studies with rodents have established that platelet-derived growth factor (PDGF), a potent chemotactic and mitogenic agent for vascular smooth muscle cells, is a key mediator of lesion formation after vascular injury. To further explore this hypothesis in a more clinically relevant model, neutralizing monoclonal antibodies (mAbs) were used to examine the effect of selective inhibition of alpha or beta PDGF receptor (PDGFR) on neointima formation in nonhuman primates. Carotid arteries were injured by surgical endarterectomy and femoral arteries by balloon catheter dilatation. Immunostaining revealed that both injuries induced cell proliferation and the upregulation of beta PDGFR but not alpha PDGFR. By 7 days after injury, beta PDGFR staining was limited to the luminal region of the media, the small areas of neointima, and the adventitia. Nearly all bromodeoxyuridine-positive cells were found in these regions as well. After 30 days, a concentric neointima that stained strongly for beta PDGFR had formed in the carotid and femoral arteries. Treatment of baboons with anti-beta PDGFR mAb 2A1E2 for 6 days after injury reduced the carotid artery and femoral artery lesion sizes by 37% (P<0.05) and 48% (P<0.005), respectively, when measured at 30 days. Under the same conditions, treatment with anti-alpha PDGFR mAb 2H7C5 had no effect. These findings suggest that PDGF mediates neointima formation through the beta PDGFR, and that antagonism of this pathway may be a promising therapeutic strategy for reducing clinical restenosis.  (+info)

Glucocorticoid resistance caused by reduced expression of the glucocorticoid receptor in cells from human vascular lesions. (6/784)

Mechanisms that control the balance between cell proliferation and death are important in the development of vascular lesions. Rat primary smooth muscle cells were 80% inhibited by low microgram doses of hydrocortisone (HC) and 50% inhibited by nanogram concentrations of transforming growth factor-beta1 (TGF-beta1), although some lines acquired resistance in late passage. However, comparable doses of HC, or TGF-beta1, failed to inhibit most human lesion-derived cell (LDC) lines. In sensitive LDC, HC (10 microg/mL) inhibited proliferation by up to 50%, with obvious apoptosis in some lines, and TGF-beta1 inhibited proliferation by more than 90%. Collagen production, as measured by [3H]proline incorporation or RIA for type III pro-collagen, was either unaffected or increased in the LDCs by HC. These divergent responses between LDC lines were partially explained by the absence of the glucocorticoid receptor (GR) and heat shock protein 90 mRNA in 10 of 12 LDC lines, but the presence of the mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II. Western blot analysis confirmed the absence of the GR protein in cells lacking GR mRNA. Immunohistochemistry of human carotid lesions showed high levels of GR in the tunica media, but large areas lacking GR in the fibrous lesion. Considering the absence of the GR in most lines, the effects of HC may be elicited through the mineralocorticoid receptor. Functional resistance to the antiproliferative and antifibrotic effects of HC may contribute to excessive wound repair in atherosclerosis and restenosis.  (+info)

Apoptosis and Bcl-xs in the intimal thickening of balloon-injured carotid arteries. (7/784)

We performed balloon injury in the rat carotid artery and identified intimal thickening after injury. Balloon-injured carotid arteries showed maximum thickness of the neointima on the 14th day before complete endothelial cell regeneration. In this lesion we identified apoptosis of vascular smooth muscle cells (VSMCs) by in situ DNA labelling and electron microscopy in the neointima on the 14th day after injury. mRNA expression levels of bcl-2, bax, bcl-x, p53 and caspase-1 were determined by the reverse transcriptase-polymerase chain reaction method both in injured and uninjured carotid arteries. Neither bcl-2 nor bcl-xl mRNA expression was detected in either injured or uninjured arteries, whereas bax and p53 mRNA expression was identified and their mRNA levels were not altered after balloon injury. In contrast, both bcl-xs and caspase-1 mRNA was detected and was markedly induced only in the injured carotid artery. Positive staining for immunoreactive Bcl-x was observed specifically in the injured arterial wall and co-localized with positive staining of nuclei identified by in situ DNA labelling. We conclude that two opposite cellular responses, VSMC proliferation and apoptosis, exist together in the neointima of the rat carotid artery after balloon injury, and selective induction of Bcl-xs expression is a key regulator of VSMC apoptosis in the process of vascular remodelling.  (+info)

Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. (8/784)

Using the rat balloon catheter denudation model, we examined the role of transforming growth factor-beta (TGF-beta) isoforms in vascular repair processes. By en face in situ hybridization, proliferating and quiescent smooth muscle cells in denuded vessels expressed high levels of mRNA for TGF-beta1, TGF-beta2, TGF-beta3, and lower levels of TGF-beta receptor II (TGF-betaRII) mRNA. Compared with normal endothelium, TGF-beta1 and TGF-beta2, as well as TGF-betaRII, mRNA were upregulated in endothelium at the wound edge. Injected recombinant soluble TGF-betaRII (TGF-betaR:Fc) localized preferentially to the adventitia and developing neointima in the injured carotid artery, causing a reduction in intimal lesion formation (up to 65%) and an increase in lumen area (up to 88%). The gain in lumen area was largely due to inhibition of negative remodeling, which coincided with reduced adventitial fibrosis and collagen deposition. Four days after injury, TGF-betaR:Fc treatment almost completely inhibited the induction of smooth muscle alpha-actin expression in adventitial cells. In the vessel wall, TGF-betaR:Fc caused a marked reduction in mRNA levels for collagens type I and III. TGF-betaR:Fc had no effect on endothelial proliferation as determined by reendothelialization of the denuded rat aorta. Together, these findings identify the TGF-beta isoforms as major factors mediating adventitial fibrosis and negative remodeling after vascular injury, a major cause of restenosis after angioplasty.  (+info)

*List of MeSH codes (C10)

... carotid artery thrombosis MeSH C10.228.140.300.200.345 --- carotid artery injuries MeSH C10.228.140.300.200.345.300 --- carotid ... carotid artery injuries MeSH C10.900.250.300.300 --- carotid artery, internal, dissection MeSH C10.900.250.300.400 --- carotid- ... carotid artery injuries MeSH C10.228.140.300.350.500.300 --- carotid artery, internal, dissection MeSH C10.228.140.300.350.500. ... carotid artery, internal, dissection MeSH C10.228.140.300.200.360 --- carotid stenosis MeSH C10.228.140.300.200.490 --- carotid ...

*Timeline of stroke

Reports of successful closures of injuries to the carotid arteries are documented. Early in the 20th century, most of the ... The earliest known stroke treatments start to happen, when surgeons begin performing surgery on the carotid arteries. Surgeons ... North American Symptomatic Carotid Endarterectomy Trial Collaborators (August 1991). "Beneficial Effect of Carotid ... In the 1960s carotid endarterectomy is greatly improved but is used mostly for stroke prevention and there is still no ...

*Thromboxane receptor

... resistant to the vascular damage caused by balloon catheter-induced injury of the external carotid artery; e) less likely to ... SNP variant rs768963 in TBX2R was associated with increased frequency of large artery atherosclerosis, small artery occlusion, ... studies on rat and human cerebral artery preparations indicate that increased blood flow through these arteries triggers ... Toth P, Rozsa B, Springo Z, Doczi T, Koller A (2011). "Isolated human and rat cerebral arteries constrict to increases in flow ...

*Basilar skull fracture

Acute injury to the internal carotid artery (carotid dissection, occlusion, pseudoaneurysm formation) may be asymptomatic or ... Involvement of the petrous segment of the carotid canal is associated with a relatively high incidence of carotid injury. ... They are almost exclusively observed when the carotid canal is fractured, although only a minority of carotid canal fractures ... Pediatric Head Trauma at eMedicine Skull Fracture at eMedicine "About Brain Injury". Brain Injury Association of America. ...

*Vertebral artery dissection

... or whiplash injury. 1-2% of those with major trauma may have an injury to the carotid or vertebral arteries. In many cases of ... The other type, carotid artery dissection, involves the carotid arteries. Vertebral artery dissection is further classified as ... Vertebral artery dissection is less common than carotid artery dissection (dissection of the large arteries in the front of the ... or for symptoms of carotid artery dissection to occur at the same time as those of vertebral artery dissection. Some give a ...

*List of MeSH codes (C14)

... carotid artery thrombosis MeSH C14.907.253.123.345 --- carotid artery injuries MeSH C14.907.253.123.345.300 --- carotid artery ... carotid artery injuries MeSH C14.907.253.535.500.300 --- carotid artery, internal, dissection MeSH C14.907.253.535.500.350 --- ... carotid artery, internal, dissection MeSH C14.907.253.123.360 --- carotid stenosis MeSH C14.907.253.123.490 --- carotid- ... carotid artery, internal, dissection MeSH C14.907.055.050.575 --- vertebral artery dissection MeSH C14.907.055.090 --- aneurysm ...

*Carotid artery dissection

The probable mechanism of injury for most internal carotid injuries is rapid deceleration, with resultant hyperextension and ... The incidence of spontaneous carotid artery dissection is low, and incidence rates for internal carotid artery dissection have ... Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing blood to the head and brain ... Treatments include observation, anticoagulation, stent implantation and carotid artery ligation. 70% of patients with carotid ...

*Brendan Marrocco

His injuries include: Amputation of both arms and both legs; Severed left carotid artery; Broken nose, left eye socket and ... As a result of the EFP entering the vehicle through his door, he sustained severe, permanent and life changing injuries. ... resulting in one fatality and two injuries. ...

*List of MeSH codes (C21)

... carotid artery injuries MeSH C21.866.915.200.200.500 --- carotid artery, internal, dissection MeSH C21.866.915.200.200.550 --- ... post-head injury MeSH C21.866.260.237 --- cranial nerve injuries MeSH C21.866.260.237.162 --- abducens nerve injury MeSH ... optic nerve injuries MeSH C21.866.260.275 --- facial injuries MeSH C21.866.260.275.250 --- eye injuries MeSH C21.866.260.275. ... post-head injury MeSH C21.866.915.300.400 --- cranial nerve injuries MeSH C21.866.915.300.400.100 --- abducens nerve injury ...

*Nathan Horton

... to help Florida win 4-2 in the game after Richard Zednik suffered a neck injury in which he had his external carotid artery cut ... I just tried to get it to the net and it went in every time." Despite missing 10 games to injury, Horton was tied with teammate ... Horton has not played in an NHL game since April 2014 due to a back injury. Though he is not officially retired, the surgery ... Horton suffered the shoulder injury in a fight in December and missed 14 games. He was informed he would again have to undergo ...

*Ischemia

... may develop as a result of arterial dissection in the carotid artery or aorta or as a result of iatrogenic arterial injury (e.g ... Reduction of body temperature also reduces the inflammation response and reperfusion injury. For frostbite injuries, limiting ... Surgical revascularization may be used in the setting of trauma (e.g., laceration of the artery). Amputation is reserved for ... Restoration of blood supply to ischemic tissues can cause additional damage known as reperfusion injury that can be more ...

*Yulia Drunina

In 1943 Drunina was seriously injured when a shell fragment struck her in the neck several millimeters from her carotid artery ... Unaware of the severity of her injury, she simply wrapped her neck in bandages and continued to work. Eventually, she was ...

*Carotid artery stenosis

... arterial injury or retroperitoneal bleeding. The investigation chosen will depend on the clinical question and the imaging ... The carotid artery divides into the internal carotid artery and the external carotid artery. The internal carotid artery ... Carotid arteries Section of carotid artery with plaque. Blood flows from the common carotid artery(bottom), and divides into ... At the throat it forks into the internal carotid artery and the external carotid artery. The internal carotid artery supplies ...

*Carotid endarterectomy

Contralateral carotid artery occlusion. Prior ipsilateral CEA. Contralateral laryngeal nerve injury. Tracheostoma. An incision ... Atherosclerosis causes plaque to form within the carotid artery walls, usually at the fork where the common carotid artery ... Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid ... and up the carotid artery. The catheter uses a balloon to expand the artery, and inserts a stent to hold the artery open. In ...

*Superior thyroid artery

This artery branches from the superior thyroid artery near its bifurcation from the external carotid artery. Together with the ... making it at risk for injury during surgery. Inferior thyroid artery Diagram showing the origins of the main branches of the ... The superior thyroid artery arises from the external carotid artery just below the level of the greater cornu of the hyoid bone ... carotid arteries. The internal carotid and vertebral arteries. Right side. (Superior thyroid visible at center.) The thyroid ...

*Rick Carelli

He suffered a basal skull fracture, damaged his carotid artery and sinus. He recovered and returned to race the entire 2000 ... Carelli raced every series race until he suffered near-fatal injuries when his truck hit the wall during a race at Memphis ...

*Abducens nerve

In the cavernous sinus it runs alongside the internal carotid artery. It then enters the orbit through the superior orbital ... Iatrogenic injury is also known to occur, with the abducens nerve being the most commonly injured cranial nerve in halo ... as can aneurysms of the intracavernous carotid artery. Mass lesions that push the brainstem downward can damage the nerve by ... This type of traction injury can affect either side first. A right-sided brain tumor can produce either a right-sided or a left ...

*Guttural pouch

Odd-toed perrisodactyls such as horses lack a carotid rete, but since the internal carotid artery passes through the guttural ... This anatomical adaptation acts to protect friable brain tissue from injury due to overheating. ... near the internal carotid artery. Clinical signs include unilateral or bilateral epistaxis due to erosion of the artery walls, ... The external carotid artery passes ventral to the medial compartment before crossing to the lateral wall of the lateral ...

*Trigenics

... direct treatment over both carotid arteries, tissues subject to highly exaggerated pain on palpation, dislocated shoulder that ... Risk of injury from trigenics can occur during manual muscle testing (strains, sprains). Due to the maximal contraction during ... and other injuries. According to the Trigenics Manual, contraindications to treatment include: nerve lesions, unexplained ... and others who are licensed to work on neuromusculoskeletal conditions/injuries as well students in those fields. To become a ...

*Chokehold

... carotid restraints or sleeper holds are a form of strangulation that compress one or both carotid arteries and/or the jugular ... However to avoid injury the hold cannot be maintained more than a few seconds. When pressure on the carotids is released, the ... In contrast, if the airway rather than the carotid arteries is blocked, the subject cannot breathe, but his brain is still ... A hold that simultaneously blocks both the left and right carotid arteries results in cerebral ischemia and loss of ...

*2007-08 NHL season

Richard Zednik of the Florida Panthers was severely injured after having his external carotid artery in his neck accidentally ... Also, the interference rule was altered to allow for a major penalty and a game misconduct when an injury results. Another ... Zednik fully recovered from the injury, but missed the remainder of the season. The Anaheim Ducks and Ottawa Senators matched ...

*George E. Goodfellow

... narrowly missing his carotid artery. A portion of the silk neckerchief was carried into the wound by the bullet, preventing a ... Goodfellow devised a wire framework and in a series of treatments successfully restored Parson's nose to his pre-injury profile ... wounds very similar to President Garfield's injury. Goodfellow followed Lister's recommended procedure for sterilizing ... more serious injury, but the scarf was undamaged. To Goodfellow, the protection offered by the silk was remarkable. He noted ...

*Central venous catheter

CVCs can be mistakenly placed in an artery during insertion (for example, the carotid artery or vertebral artery when placed in ... CVC misplacement is more common when the anatomy of the person is different or difficult due to injury or past surgery. ... The color of the blood and the rate of its flow help distinguish it from arterial blood (suggesting that an artery has been ... Uncommonly, the vein can fuse with the artery after being damaged by insertion of the catheter. Ultrasound use is efficient at ...

*Bulletproofing

... narrowly missing his carotid artery. A portion of his silk neckerchief was carried into the wound by the bullet, preventing a ... to protect personnel from death or serious injuries. There are various mandatory tests which items must pass before they can be ... more serious injury, but the scarf was undamaged. The Tombstone Epitaph reported, "A silken armor may be the next invention." ...

*Neck guard

... hitting Zedník's external carotid artery. Clutching his neck, Zedník raced to the Florida bench, leaving a long trail of blood ... Goalie Clint Malarchuk suffered a severe injury during a game in 1989 when two players collided in front of his goal and one ... The guard is designed to prevent injury to the neck by pucks, hockey sticks, and skate blades. This piece is critical to ... He fully recovered from the injury. Most neck guards, such as those manufactured by Bauer, contain fabric that is BNQ (Bureau ...

*Brain ischemia

Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, ... Reperfusion injury is classified as the damage that ensues after restoration of blood supply to ischemic tissue. The symptoms ... Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as ... endarterectomy and carotid stenting may be performed if the patient has a significant amount of plaque in the carotid arteries ...
Rat carotid artery balloon injury model / David A. Tulis -- Histological and morphometric analyses for rat carotid balloon injury model / David A. Tulis -- Plaque rupture model in mice / Takeshi Sasaki, Kae Nakamura and Masafumi Kuzuya -- Immunostaining of mouse atherosclerotic lesions / Hong Lu, Debra L. Rateri and Alan Daugherty -- Surgical animal model of ventricular hypertrophy / Giuseppe Marano and Alberto U. Ferrari -- Animal models of hypertension / Brett M. Mitchell, Thomas Wallerath and Ulrich Förstermann -- Rat models of cardiac insulin resistance / Sanjoy Ghosh, Brian Rodrigues and Jun Ren -- The Isolated, perfused pseudo-working heart model / Gary J. Grover and Rajni Singh -- Altering and analyzing glucose metabolism in perfused hearts of transgenic mice / Rajakumar V. Donthi and Paul N. Epstein -- Methods in the evaluation of cardiovascular renin angiotensin aldosterone activation and oxidative stress / Camila Manrique -- Detection and quantification of apoptosis in the vasculature ...
Mitoxantrone suppresses vascular smooth muscle cell (VSMC) proliferation and balloon injury-induced neointima formation: An in vitro and in vivo study
Discussion. Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging modalities and management options, the morbidity and mortality associated with BCI is over 30%, largely due to stroke.[1] Bilateral injuries to the ICA are exceptionally rare, with experience limited to case reports only.[2]. A high index of suspicion is essential in detecting this often clinically occult injury. Biffl et al.[3] have shown that aggressive screening using the Denver screening criteria (Table 1) to decide on the need for investigation[4] has increased the detection rate for BCI from 0.1% to 0.86%. In addition, they showed an improvement in neurological outcome in asymptomatic BCI patients who were anticoagulated.. Biffls grading system based on investigative angiographic findings has management and prognostic implications outlined- in Table 2.[4] Grade I and II injuries are of particular concern and require follow-up angiography owing to the ...
METHODS AND RESULTS: PI3K/p110α was inhibited by treatment with the small molecule inhibitor PIK75 or a specific siRNA. Arterial thrombosis, neointima formation, and re-endothelialization were studied in a murine carotid artery injury model. Proliferation and migration of human vascular smooth muscle cell (VSMC) and endothelial cell (EC) were assessed by cell number and Boyden chamber, respectively. Endothelial senescence was evaluated by the β-galactosidase assay, endothelial dysfunction by organ chambers for isometric tension. Arterial thrombus formation was delayed in mice treated with PIK75 when compared with controls. PIK75 impaired arterial expression and activity of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1); in contrast, plasma clotting and platelet aggregation did not differ. In VSMC and EC, PIK75 inhibited expression and activity of TF and PAI-1. These effects occurred at the transcriptional level via the RhoA signalling cascade and the transcription factor ...
Here we provide the first evidence that 2-ME protects against injury-induced neointima formation in rats and arrests growth of human aortic SMCs via double blockade of the cell cycle. We demonstrate that 2-ME: (1) arrests proliferating SMCs in G0/G1 and G2/M-phases; (2) inhibits the signaling pathways ERK1/2 and Akt; (3) inhibits the expression and activation of key proteins responsible for the progression of cells into the DNA replicating phase (such as cyclin D1 expression and cdk4 activity associated with it and pRb phosphorylation); (4) upregulates the expression of the cdk inhibitor p27, suggesting that 2-ME can block HASMCs in G0/G1 phase via 2 different mechanisms; (5) inhibits cyclin B1 expression and cdk1 activity associated with it (essential for G2-to-M progression); (6) inhibits tubulin polymerization, a critical process in cell division; (7) induces COX-2 expression (known to mediate antiproliferative actions in SMCs); and (8) does not induce apoptosis, suggesting that the growth ...
Ji and colleagues describe a dynamic profile of miRNA changes several days after injury of the rat internal carotid artery.11 They report 113 differentially expressed miRNAs of the 140 detectable in arterial tissue. Indicative of a chronic response, 102 miRNA species continue to be expressed at significantly different levels 28 days after injury. After confirming the differential expression of the most significantly altered miRNAs by real-time PCR and northern blotting, they focus on miR-21 as the most robustly induced miRNA to determine its biological significance. The selection of miR-21 is also notable because it has recently been found to promote tumor growth implicating its role in cell proliferation, a hallmark of restenotic neointimal lesions.12. Returning to the original carotid injury model, the authors tested the biological effect of knocking down miR-21 using modified antisense oligonucleotides locally delivered in a special pluronic gel. They confirm localization of the ...
Growing evidence in clinical studies suggests that ubiquitin systems are greatly related to the progression of atherosclerosis, particularly in relation to inflammation and cell proliferation. However, there were few reports referred to molecular mechanisms of vascular remodeling related to ubiquitin systems. NF-κB is an important transcriptional factor which plays central roles in pathogenesis of atherosclerosis. Thus, in this study, we focused on CYLD which is a NF-κB-related deubiquitinating enzyme and may be a therapeutic target of tumor in cancer research. From Northern blot and immunohistology, CYLD was endogenously expressed in vascular endothelial cells (EC) and smooth muscle cells (VSMC). Interestingly, the treatment of TNF-α significantly increased CYLD expression in EC and VSMC. CYLD was markedly induced in the neointima of the balloon-injured carotid arteries, and was also present in atherosclerotic lesions from human carotid arteries. Thus, the expression of CYLD could be ...
In the present study, we showed that overexpression of Mst1 induced VSMC apoptosis in vitro and in vivo and suppressed neointimal formation in balloon-injured artery. This is the first report examining the function of Mst1 in VSMCs and in balloon-injured artery. A recent study reported that cardiac-specific overexpression of Mst1 causes dilated cardiomyopathy,17 suggesting that apoptosis of cardiac myocytes impairs cardiac function. However, overexpression of Mst1 in injured artery has anti-proliferative effect by stimulating apoptosis, which may be used as a therapeutic tool for vascular proliferative lesion such as in-stent restenosis.. Numerous animal models of acute balloon injury of artery have documented apoptotic VSMC death. Several studies demonstrated that balloon injury of vessels induces two waves of VSMC apoptosis. The first wave of apoptosis occurred in the media within hours of the injury.5 The second wave occurs at much later times after injury (days to weeks). VSMC accumulation ...
Aberrant EC recovery is inversely related to neointima formation during atherosclerosis and postinjury restenosis. Our current study revealed ADAMTS-7 as a potent inhibitor of endothelial recovery in response to injury. Using Adamts7-/- mice and injury models, we uncovered that, in addition to the suppression of VSMC migration, ADAMTS-7 deficiency also promoted re-endothelialization and completely blocked subsequent neointima formation. ADAMTS-7 inhibition, therefore, is a promising dual-effect target for both atherosclerosis and restenosis after PCI.. The ADAMTS-7 locus was identified to have a strong association with coronary atherosclerotic disease14,15 and was rather involved in the formation of atherosclerotic plaques in comparison with atherothrombotic events. However, the underlying mechanism is not yet understood. In the current phenotype screening assay, we did not observe difference regarding lipid metabolism. As shown in Table IV in the online-only Data Supplement, without a ...
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R.S.M.P., R.A.M.P. போட்டுக்கொண்டாலும் அவர்களுக்கு உரிய மருத்துவ கவுன்சிலில் பதிவு செய்திருக்க மாட்டார்கள். பதிவு செய்ய வேண்டுமென்றால் அவர்கள் பட்டம் பெற்றிருக்க வேண்டும். பக்கத்தில் உள்ள அச்சகத்திலோ (இப்போது கம்யூட்டர் செண்டரில் ) ஒரு காகிதத்தில் அச்சடித்து பிரேம் போட்டு மாட்டிக் கொண்டு தொழில் செய்பவர்களை காவல்துறை அவ்வப்போது கைது செய்து கொண்டேதான் இருக்கிறார்கள். I M Aவும் இது ...
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Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean?
TY - JOUR. T1 - Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. AU - Sibinga, Nicholas E S. AU - Foster, Lauren C.. AU - Hsieh, Chung Ming. AU - Perrella, Mark A.. AU - Lee, Wen Sen. AU - Endege, Wilson O.. AU - Sage, E. Helene. AU - Lee, Mu En. AU - Haber, Edgar. PY - 1997. Y1 - 1997. N2 - To identify genes involved in vascular remodeling, we applied differential mRNA display analysis to the rat carotid artery balloon injury model. One polymerase chain reaction product showing increased expression at days 2 to 14 after vascular injury was nearly identical to the mouse α1 chain of type VIII collagen, a heterotrimeric short-chain collagen of uncertain function expressed by a limited number of cell types. By Northern analysis, expression of both chains of the type VIII collagen heterotrimer increased: collagen α1 (VIII) mRNA expression was almost 4-fold higher than control by 7 days after vascular injury, and collagen α2 (VIII) mRNA expression reached ...
TY - JOUR. T1 - Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury.. AU - Yoshida, Tadashi. AU - Yamashita, Maho. AU - Horimai, Chihiro. AU - Hayashi, Matsuhiko. PY - 2014. Y1 - 2014. N2 - Krüppel-like factor 4 (Klf4) is involved in a variety of cellular functions by activating or repressing the transcription of multiple genes. Results of previous studies showed that tamoxifen-inducible global deletion of the Klf4 gene in mice accelerated neointimal formation following vascular injury, in part via enhanced proliferation of smooth muscle cells (SMCs). Because Klf4 is also expressed in non-SMCs including endothelial cells (ECs), we determined if Tie2 promoter-dependent deletion of Klf4 in ECs and hematopoietic cells affected injury-induced neointimal formation. Klf4 conditional knockout (cKO) mice were generated by breeding Tie2-Cre mice and Klf4 floxed mice, and their phenotype was analyzed after carotid ligation ...
The present study demonstrates that arginase plays a fundamental role in vascular growth after injury. Arterial injury stimulates arginase activity and arginase I protein expression in the vessel wall, and local arginase inhibition leads to a significant decline in VSMC DNA synthesis and reduced intimal thickening. In addition, this study shows that arginase promotes the entry of VSMCs into the cell cycle. Arginase inhibition or arginase I knockdown arrests VSMCs in G0/G1, and this is associated with the induction of the cyclin-dependent protein kinase inhibitor, p21. These findings illustrate a critical role for arginase in cell cycle progression and identify arginase I as a novel therapeutic target for the treatment of occlusive vascular disorders.. In the present study, we are the first to demonstrate that arginase plays an integral role in the remodeling response after arterial injury. Balloon injury of rat carotid arteries resulted in a sustained increase in arginase activity in the vessel ...
PAN Czytelnia Czasopism, Safety of the long-term application of QuikClot Combat Gauze, ChitoGauze PRO and Celox Gauze in a femoral artery injury model in swine - a preliminary study - Polish Journal of Veterinary Sciences
REFEREED JOURNAL ARTICLES. Yang, X, Thomas, DP, Zhang,X, Culver, BW, Alexander, BM, Murdoch, WJ, Rao, MN, Tulis, DA, Ren, J, Sreejayan, N. (2006) Curcumin Inhibits Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol. 26: 85-90.. Dong F, Zhang X, Li S-Y, Zhang Z, Ren Q, Culver B, Ren J. 2005. Involvement of NADPH oxidase and JNK in homocysteine-induced oxidative stress and apoptosis in human umbilical vein endothelial cells. Cardiovasc. Toxicol. 5:9-20.. Li S-Y, Golden KL., Jiang Y, Graham C, Wang G-J, Privratsky JR, Zhang X, Eason AR, Culver B, Ren J. 2005. Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocyte from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. Cell Biochem Biophys. 42: 1-12.. Li S-Y, Culver B, Ren J. 2003. Benefit and risk of exercise on myocardial function in diabetes. ...
Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice. - Huan Wang, Weiyu Zhang, Rong Tang, Robert P Hebbel, M Anna Kowalska, Chunxiang Zhang, Jamey D Marth, Minoru Fukuda, Chuhong Zhu, Yuqing Huo
Vascular injuries in lower limbs are rare but serious events. If not detected and managed correctly and timely they can lead to permanent functional impairment and even limb loss. The increasing number of orthopaedic interventions, worldwide, makes awareness of this problem among orthopaedic surgeons important.. The overall aim of this thesis was to describe lower limb orthopaedic injuries with associated concomitant arterial injuries, especially to the popliteal artery. Epidemiology, mechanisms of injury, management, outcomes and the patient perspective were all addressed. The research questions were generated from clinical praxis. Vascular injuries are rare events, but by using as the National Patient (NPR) and National Vascular registries (Swedvasc) a relatively speaking large cohort was studied. Deep interviews with qualitative study method were used to investigate the patients perspective.. In papers I and II iatrogenic popliteal artery injuries (PAI) in knee-replacements, and in ...
Arteriosclerosis Disease risk arising from the concentration of lipids on the inner membrane of the arteries, causing Bansdadha partially or completely. This may cause the disease to disability and death, as it may lead to diseases vary according to the affected area, leading injured arteries of the brain to the nervous system and brain, while the injured arteries of the parties, could cause a deficiency in the blood supply to the muscles of the legs, and the injury of the coronary arteries leading to angina a heart attack. And the factors that lead to the disease many of them: A high proportion of fat in the food. 2 smoking. 3 high blood pressure. 4 alcohol consumption. 5 lack of movement. 6 stress and tension. 7 diabetes. 8 menopause and the accompanying hormonal secretions. 9 obesity. 10 years old. Genetics 11. 12 Gender. 13 categories of blood. One way to prevent this disease that follows the one the following tips: A reduction of weight and avoid foods that help the accumulation of grease ...
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TY - JOUR. T1 - Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs. AU - Eto, Yasuhiro. AU - Shimokawa, Hiroaki. AU - Hiroki, Junko. AU - Morishige, Kunio. AU - Kandabashi, Tadashi. AU - Matsumoto, Yasuharu. AU - Amano, Mutsuki. AU - Hoshijima, Masahiko. AU - Kaibuchi, Kozo. AU - Takeshita, Akira. PY - 2000/6. Y1 - 2000/6. N2 - Restenosis after angioplasty still remains a major problem for which neointimal formation appears to play an important role. Recent studies in vitro suggested that Rho kinase, a target protein of Rho, is important in various cellular functions. We thus examined whether Rho kinase is involved in the restenotic changes after balloon injury. In vivo gene transfer was performed immediately after balloon injury in both sides of the porcine femoral arteries with adenoviral vector encoding either a dominant negative form of Rho kinase (AdDNRhoK) or β-galactosidase (AdLacZ) as a control. One week after the transfer, ...
Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. No sex-based differences were observed. Mechanistic studies suggested that Fn-EDA mediates integrin- and TLR4-dependent proliferation and migration through activation of FAK/Src and Akt1/mTOR signaling, respectively. Specific deletion of Fn-EDA in SMCs, but not in endothelial cells, reduced intimal hyperplasia and suppressed the SMC synthetic phenotype concomitant with ...
Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. No sex-based differences were observed. Mechanistic studies suggested that Fn-EDA mediates integrin- and TLR4-dependent proliferation and migration through activation of FAK/Src and Akt1/mTOR signaling, respectively. Specific deletion of Fn-EDA in SMCs, but not in endothelial cells, reduced intimal hyperplasia and suppressed the SMC synthetic phenotype concomitant with ...
Background Traumatic paediatric arterial injuries are a great challenge due to low incidence and specific characteristics of paediatric anatomy and physiology. The aim of the present study was to...
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Hiii guyz i m back…… Sorry 4r late frnds but i cant do anything this week i m quite bz with eid but from this monday my new classes is starting n i am a medical studnt soo now from nxt week i gonna really very busy with classes n tutions soo i will try my best to upload one epi atleast in a week… N thanks to all who
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CMV is thought to be a key pathogen involved in the pathogenesis of TV in human allografts. To evaluate the direct effect of CMV infection on vascular biology, we used a rat model in which aortic allografts were infected ex vivo with RCMV prior to transplantation. We chose 2 time points after transplantation to investigate the development of TV, 2 weeks that represented the early phase of TV in rats; and 8 weeks, when TV was fully developed. We found that RCMV influenced vascular remodeling by increased apoptosis of SM-α-actin positive cells in the media layer, decreased extracellular matrix deposits and increased intimal hyperplasia. Moreover, RCMV induced a strong infiltration of CD68-positive macrophages mainly in the adventitia and resulted in an increase of MCP-1 in the allograft, which resulted in migration of adventitial cells towards the intima that most likely also contributed to intimal hyperplasia.. Vessel stability is sustained by a balance between cellular proliferation and ...
The goal of this project is to define the role of peroxisome proliferator-activated receptor (PPAR)3 activation in neointima formation. Neointima formation occu...
Xingsen Xu, Peijian Wang, Zhigang Zhao, Tingbing Cao, Hongbo He, Zhidan Luo, Jian Zhong, Feng Gao, Zhenyu Zhu, Li Li, Zhencheng Yan, Jing Chen, Yinxing Ni, Daoyan Liu and Zhiming Zhu ...
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Hi, I m new to Sencha Touch, made my first trials with it and recognized that I have to deal with a lot of code. I mention this deal with a lot of code because I m not the youngest anymore (66 years), programmed in my young days and don`t have now the nerves to deal with all the detailed code things. So I looked at the Net for easier ways and found for example Tersus. Now my question: When I want to create webapps (mobile and for the PC) would you suggest using Tersus in my case? Of
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Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.. ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Background We discovered the gene Collagen Triple Helix Repeat Containing 1 (Cthrc1) and reported its developmental expression and induction in adventitial cells of injured arteries and dermal cells of skin wounds. The role of Cthrc1 in normal adult tissues has not yet been determined. Methodology/Principal Findings We generated mutant mice with a novel Cthrc1 null allele by homologues recombination. Cthrc1 null mice appeared developmentally normal. On the C57BL/6J background, livers from Cthrc1 null mice accumulated vast quantities of lipid, leading to extensive macrovesicular steatosis. Glycogen levels in skeletal muscle and liver of Cthrc1 null mice on the 129S6/SvEv background were significantly increased. However, Cthrc1 expression is not detectable in these tissues in wild-type mice, suggesting that the lipid and glycogen storage phenotype may be a secondary effect due to loss of Cthrc1 production at a distant site. To investigate potential hormonal functions of Cthrc1, tissues from adult mice
Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association. ...
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A) To determine whether biosynthesis of PGD2 is altered in response to vascular injury in humans. B) Patients will be grouped base on their aspirin using status. There groups of no aspirin but an alternative anti-platelet medicine, low dose (81 mg) aspirin, high dose 325 mg aspirin will be enrolled. ...
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The present study is the first to demonstrate that a continuous supply of tissue kallikrein by way of gene transfer suppresses neointima formation in balloon-injured artery. Balloon angioplasty resulted in decreased endogenous rat tissue kallikrein expression. Expression of recombinant human tissue kallikrein at the injured site results in significant reduction of intima/media ratio and neointima formation, and time-dependent increases of cAMP and cGMP levels. Icatibant, a bradykinin B2 receptor antagonist, abolished both the protected effect of kallikrein on arterial thickening and the increases in cAMP and cGMP levels. Kallikrein gene transfer also suppresses the proliferation of VSMCs in vitro. These results suggest that inhibition of neointima formation in injured artery after kallikrein gene delivery is mediated by kinin with subsequent activation of second messengers such as cAMP and cGMP in blood vessels. These findings provide important insights into the role of the vascular ...
Blunt carotid and vertebral artery injury, collectively termed blunt cerebrovascular injury, are rare but potentially devastating events. In the past, blunt carotid injury was associated with mortality rates ranging from 23 to 28 percent, with 48 to
inproceedings{138201, author = {Ping, QB and Yanming, H and Wang, L and Vermeire, I and Verbeken, E and Schacht, Etienne and De Scheerder, IK}, booktitle = {JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY}, issn = {0735-1097}, language = {eng}, number = {2 (Suppl. A)}, pages = {74A--74A}, title = {Methylprednisolone coated stents decrease neointimal hyperplasia in a porcine coronary model}, volume = {37}, year = {2001 ...
TY - JOUR. T1 - Activated forkhead transcription factor inhibits neointimal hyperplasia after angioplasty through induction of p27. AU - Park, Kyung Woo. AU - Kim, Dae Hee. AU - You, Hyun Jung. AU - Sir, Jung Ju. AU - Jeon, Soo In. AU - Youn, Seock Won. AU - Yang, Han Mo. AU - Skurk, Carsten. AU - Park, Young Bae. AU - Walsh, Kenneth. AU - Kim, Hyo Soo. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Objective - We examined the effects of FKHRL1 (forkhead transcription factor in rhabdomyosarcoma like-1) overexpression on vascular smooth muscle cell (VSMC) proliferation, apoptosis, and cell cycle, in vitro, and the role of FKHRL1 and p27 in the pathophysiology of neointimal growth after balloon angioplasty, in vivo. Furthermore, we tested whether FKHRL1 overexpression can inhibit neointimal hyperplasia in a rat carotid artery model. Methods and Results - Adenovirus expressing the constitutively active FKHRL1 (FKHRL1-TM; triple mutant) with 3 Akt phosphorylation sites mutated was transfected to subconfluent ...
The latest market report published by Credence Research, Inc. "Balloon Catheters Market - Growth, Future Prospects, Competitive Analysis, 2017 - 2025," the global balloon catheters market was valued at US$ 2,989.0 Mn in 2016, and is expected to reach US$ 5,457.2 Mn by 2025 expanding at a CAGR of 6.78 % from 2017 to 2025.. Browse the full report Balloon catheters Market - Growth, Future Prospects, Competitive Analysis, 2017 - 2025 report at http://www.credenceresearch.com/report/balloon-catheters-market. Market Insights:. The balloon ends of the balloon catheters is very important aspect as it might cause trauma to the vascular endothelial tissues during inflation and hence rounded balloons are preferred more in comparison to other shapes. Two types of balloons are used for surgical procedures, first is the high pressure non elastic balloons and the second is low pressure elastic balloons. These balloons are categorized as non-compliant, semi compliant and high compliant on the basis of the ...
A balloon catheter can include an actively steerable element for adjusting the configuration of the balloon after placement at a target location. By coupling the actively steerable element to the balloon, any articulation of the actively steerable element will also re-configure the position of the balloon, thereby enabling greater control over procedures that make use of such a balloon catheter. The active steering capability can also enhance the material manipulation capabilities of the balloon catheter, and enable operations and actions that are not possible with a non-steerable balloon catheter.
Peripheral Vascular Interventions: An Illustrated Manual by Juergen Schroeder English | 2013 | ISBN: 3131697512 | 240 pages | PDF | 6,4 MB Peripheral Vascular Interventions: An Illustrated M
Translation of balloon catheter | Balmes and colleagues also performed peripheral airway lavage using a modified balloon catheter to isolate specific airw
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Bakgrund: Human Immunodeficiency virus eller humant immunbristvirus (HIV) och Acquired Immunodeficiency Syndrome (AIDS) är en obotlig sjukdom som gör att kroppens eget immunförsvar bryts ner. I mötet vid omvårdnaden av patienter krävs det att sjuksköterskan har en helhetskompetens för att på ett värdigt och respektfullt sätt kunna bemöta patienten. Sjuksköterskors ansvar är att lindra lidande och främja hälsa, vilket är grunden till en god omvårdnad. Svensk sjuksköterskeförening poängterar att alla människor har rätt till lika vård oavsett sjukdom och att diskriminering på särskilda patientgrupper inte får förekomma. Därför är det viktigt att belysa sjuksköterskor i mötet vid omvårdnaden av patienter med HIV/AIDS. Syfte: Syftet med denna studie var att belysa sjuksköterskor i mötet vid omvårdnaden av patienter som drabbats av HIV/AIDS. Metod: Metoden som användes var en litteraturstudie med kvalitativ ansats där åtta artiklar valdes ut och analyserades med ...
Learn more about AngioSculpt XL PTA scoring balloon catheter. View specifications, download support documents and discover related products.
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As I´m writing this I´m thinking, wow never ever would I have thought saying these things one day. I´m not a spiritual person, but my tinnitus took me on that path, so I think this is exaclty where I need to be and I´m supposed to follow down this road.. I´m convinced that there is a reason that I´m on that path right now and without my tinnitus I would not be on it. I believe I got it for a reason and that reason might just be selfdiscovery - to find my true inner self, to finally come to peace.. Lousie Hay said that our bodys produce illnesses in order to show us an imbalance or what we need to work on. Causes of symptoms according to Louise Hay is a good place to start if you are looking for healing. Illness however mild or severe is an indicator of your emotional state, caused by your thoughts and focus.. ...
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Define Coronary artery balloon dilation. Coronary artery balloon dilation synonyms, Coronary artery balloon dilation pronunciation, Coronary artery balloon dilation translation, English dictionary definition of Coronary artery balloon dilation. angioplasty balloon angioplasty n. pl. an·gi·o·plas·ties Surgical repair of a blood vessel, especially the widening of a narrowed blood vessel by means of...
BioAssay record AID 167575 submitted by ChEMBL: In vitro functional antagonistic testing by obtaining ET-1 concentration response curves in rabbit carotid artery rings in the presence or absence of antagonist..
The latest market report published by Credence Research, Inc. "Balloon Catheters Market - Growth, Future Prospects, Competitive Analysis, 2017 - 2025," the global balloon catheters market was valued at US$ 2,989.0 Mn in 2016, and is expected to reach US$ 5,457.2 Mn by 2025 expanding at a CAGR of 6.78 % from 2017 to 2025.. Browse the full report Balloon catheters Market - Growth, Future Prospects, Competitive Analysis, 2017 - 2025 report at http://www.credenceresearch.com/report/balloon-catheters-market. Market Insights:. The balloon ends of the balloon catheters is very important aspect as it might cause trauma to the vascular endothelial tissues during inflation and hence rounded balloons are preferred more in comparison to other shapes. Two types of balloons are used for surgical procedures, first is the high pressure non elastic balloons and the second is low pressure elastic balloons. These balloons are categorized as non-compliant, semi compliant and high compliant on the basis of the ...
Subject: Yawkee Kippur. Lots to Atone for with This Sorry Bunch.. John-Gone Harrington. I m sorry I ever came back to Boston after the Attack. I should have just stayed in Canada and worked for AccounTemps. And I m sorry I can t make the Army game at Alumni Stadium on Saturday I have a Major League Baseball (who I ve worked for exclusively the last three years) event to attend.. Duke. I m sorry I gave Carl that extension after last year. I m sorry I never stuck up for Jimy. I m sorry I grossly overpaid for Offerman and added an extra year to boot. I m sorry I said Roger was in the twilight of his career. I m sorry I got rid of Alice Sele. I m sorry I drove The Hit Dog out of town. I m sorry about Bragg for Moyer. I m sorry about Steve Avery as Roger s replacement. I m sorry I gave the OK to put that fake chat up on redsox.com. I m sorry I don t know how to talk to the fans. I m sorry that no one believes I actually grew up in Massachusetts. I m sorry we didn t get Mussina and Juan Gonzalez ...
To better detect blunt cerebrovascular injuries (BCVI) in patients admitted to hospital emergency departments after experiencing high-energy trauma, computed...
China Dilation Balloon Catheter catalog of Dilation Balloon Catheter, Changmei Medtech Dilation Balloon Catheter provided by China manufacturer - Jiangsu Changmei Medtech Co., Ltd., page1.
A steerable balloon catheter including a balloon catheter supported by a steerable guidewire having a deflectable distal tip. The guidewire comprises a longitudinal hypotube and a spring coil attached to the distal end of the hypotube and includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the distal tip of the balloon catheter.
All material 1999-2018 Nucleus Medical Media Inc. All rights reserved.. Nucleus Medical Media does not dispense medical or legal advice.See additional information. ...
I seem to be having good days and not as good days lately with my developing range. I always try to do 4 sets of 2 octave scales (once slurred and once tongued) and sometimes the hi F# seems easy and good and some days I only get it 2 of the 4 times I try. When I get it all 4 times that s a Good day. Also some days the notes get a little wobbly below low a, usually toward the end of my day. Some weeks I can go almost 6-7 days straight good and then have 3-4 not so good. I should also say I have only been able to do this as part of a good scale for about 1-2 months. I m not getting pressure but I m not getting my tongue level coordinated very well above hi C especially when I tongue. I really want to have articulation to my highest usable note but I m missing something. Things are improving steadily and I m playing more above the staff each day. Is this normal to have fits and starts when developing range. I m going to start going to G as soon as I feel I get the tongue down. I can sound it but ...
CLEVELAND The woman s voice was frantic and breathless, and she was choking back tears. Help me. I m Amanda Berry, she told a 911 dispatcher. I ve been kidnapped and I ve been missing for 10 years and I m, I m here, I m free now.
when i`m power on the button, the nokia logo flash and automatically switch off it. whats the problem....? any one - Nokia 5310 Cellular Phone question
【市場調査レポート】バルーンカテーテルの世界市場ー産業および機会分析ー2016-2026:通常型バルーンカテーテル、カッティングバルーンカテーテル、スコアリングバルーンカテーテル、薬剤溶出型バルーンカテーテル、ステントグラフトバルーンカテーテル | 発行日:2016年9月26日 | 商品コード:FMI612026 | 発行/調査会社:Future Market Insights | Balloon Catheter Market: Global Industry Analysis and Opportunity Assessment, 2016-2026 | キーワード:グローバル、医療、バルーンカテーテル、通常型バルーンカテーテル、カッティングバルーンカテーテル、スコアリングバルーンカテーテル、薬剤溶出型バルーンカテーテル、ステントグラフトバルーンカテーテル [市場規模/動向/予測など世界の産業分析レポート販売のマーケットレポート.jp]
I´m working at home today, with a lot off stuff that we are going to use on a fun photoshoot on friday, it´s a creative chaos al over my apartment, I like it. But the bad thing is that it´s also creative fever here, literally speeking. I´m sick, and I´m so sick about it! But it doesn´t stop me. Here are som pictures from today!. ...
i m suffering from vaginal itching since long time. i apply candidB tube n candid v6 to insert in to vagina.n now i feel the vagina very dry since 15days. i m having fissurs in anal area since 3 ...
Ok, I figured I d try a new interactive. This interactive is set, again, within the rules of World of Darkness using its setting and systems. So I m going to go through a simplified character creation process to kick this off, To begin, you have to choose what race you want to play (most popular gets picked) ---------------------------------------------------------------------------------- STEP 1: CHARACTER CREATION Human
Hi I have red cheeks from a periodf heavy drinking many years ago. I ve tried everything and I n now 4 IPL treatments in with 3 more to go but still see no improvements. I am being told it will improve but I m starting to lose faith. Any advise pls
Niniejszy serwis internetowy jest przeznaczony dla lekarzy weterynarii oraz hodowców zainteresowanych chowem, hodowlą i szeroko pojętą tematyką zdrowia kóz. Mamy nadzieję, że informacje w nim zawarte są przydatne i mogą być wykorzystane w codziennej pracy. Będziemy wdzięczni za wszelkie uwagi na temat naszego serwisu. Serwis ten jest prowadzony w Zakładzie Chorób Zakaźnych i Epidemiologii Katedry Nauk Klinicznych Wydziału Medycyny Weterynaryjnej SGGW w Warszawie. Powstał w trakcie realizacji grantu KBN 3 P06K 020 22 Dynamika szerzenia się zakaźnego zapalenia stawów i mózgu kóz w Polsce. Serwis redagują: dr Jarosław Kaba lek. wet. Mariusz Nowicki
Is a N210 any good at folding? No? Im building a new rig for some outdoor cameras and I´m using some old part (i920, a Noctua 14 and some nice Muskins) but...
Kollagen ger strukturellt stöd till ben, hud, muskler och senor och är det mest rikliga proteinet i människokroppen. Ett antal ben- och…
Neointimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of arterial walls and decreased arterial lumen space. Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as stenting or angioplasty. The term neointima is used because the cells in the hyperplastic regions of the vascular wall have histological characteristics of both intima and normal artery cells. Neointimal hyperplasia first develops with damage to the arterial wall, followed by platelet aggregation at site of injury, recruitment of inflammatory cells, proliferation and migration of vascular smooth muscle cells, and collagen deposition. Mechanical injury of arterials due to stretching of arterial walls with a balloon catheter results in the recruitment of cells such as monocytes, macrophages, and neutrophils to the site of injury. Macrophages in particular express many growth factors, ...
Vascular injuries in lower limbs are rare but serious events. If not detected and managed correctly and timely they can lead to permanent functional impairment and even limb loss. The increasing number of orthopaedic interventions, worldwide, makes awareness of this problem among orthopaedic surgeons important.. The overall aim of this thesis was to describe lower limb orthopaedic injuries with associated concomitant arterial injuries, especially to the popliteal artery. Epidemiology, mechanisms of injury, management, outcomes and the patient perspective were all addressed. The research questions were generated from clinical praxis. Vascular injuries are rare events, but by using as the National Patient (NPR) and National Vascular registries (Swedvasc) a relatively speaking large cohort was studied. Deep interviews with qualitative study method were used to investigate the patients perspective.. In papers I and II iatrogenic popliteal artery injuries (PAI) in knee-replacements, and in ...
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Principal Investigator:KITAICHI Masanori, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Respiratory organ internal medicine
A method is disclosed for inhibiting intimal hyperplasia in a warm-blooded mammal which comprises administering topically at the site and time of a vascular injury induced by arterial intervention in said mammal a small but inhibitorily effective amount of tissue factor pathway inhibitor (TFPI) sufficient to inhibit said intimal hyperplasia.
This compact, richly illustrated text presents a uniquely visual representation of the procedures interventionalists need to master to perform peripheral vascular interventions successfully.
This channel includes news and new technology innovations for angioplasty balloon catheters (PTA). In addition to POBA, this section includes news about valvuloplasty balloons and specialty cutting balloon.
Balloon catheter comprising an elongate distal section and a flexible and expandable balloon accommodating said distal section, further comprising means for the supply of a pressure medium for expansi
An educational economy model of the brain. Color markings illustrate arteries (red) and cranial nerves (yellow). Dissects into 8 parts. Life-size, on base. Size: 5 x 6 x 6.
Fibrin has been found to have many promising applications within the medical field, such as enhancing the endothelialization of peripheral vascular grafts in vitro [18]and promoting operative hemostasis during cardiovascular surgery [19-21]. Studies in the porcine coronary model indicate that native fibrin is deposited at the site of arterial injury and, in part, determines the neointimal response [5, 10]. This evidence prompted the first study assessing the response of the arterial wall to fibrin-coated stents [12].. Using the same porcine coronary model, 34 such stents were placed in 20 animals with no acute complications. Follow-up angiography at 28 days confirmed patency in all 31 remaining stented coronary segments. In all cases the fibrin was still structurally intact and completely endothelialized. Importantly, there was no exaggerated neointimal response or foreign body reaction to the fibrin stent, and local vascular integrity was maintained.. The use of autologous vein grafts to ...
Little, Peter J., Ballinger, Mandy L., Survase, Soniya, Osman, Narin, Ogru, Esra, Geytenbeek, Stephen, Bruemmer, Dennis and Nigro, Julie (2008) Phosphorylated troglitazone activates PPAR gamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis. Journal of Cardiovascular Pharmacology, 51 3: 274-279. ...

Prospective evaluation of screening multislice helical computed tomographic angiography in the initial evaluation of...Prospective evaluation of screening multislice helical computed tomographic angiography in the initial evaluation of...

MCTA correctly identified two tracheal and two carotid artery injuries requiring operative or endovascular repair in ... MCTA correctly identified two tracheal and two carotid artery injuries requiring operative or endovascular repair in ... MCTA correctly identified two tracheal and two carotid artery injuries requiring operative or endovascular repair in ... MCTA correctly identified two tracheal and two carotid artery injuries requiring operative or endovascular repair in ...
more infohttps://miami.pure.elsevier.com/en/publications/prospective-evaluation-of-screening-multislice-helical-computed-t

Bilateral central retinal artery occlusion in Wegeners granulomatosis and α1 antitrypsin deficiency | British Journal of...Bilateral central retinal artery occlusion in Wegener's granulomatosis and α1 antitrypsin deficiency | British Journal of...

Ultrasound of his carotid arteries was normal. His vision gradually improved, and was recorded 6 days later as 6/12 in the ... Deficiency of AAT results in progressive emphysema and liver injury.6 Research suggests an increased incidence of WG in ... Lamprecht P, Lerin-Lozano C, Reinhold-Keller E, et al. Retinal artery occlusion in Wegeners granulomatosis. Rheumatology 2000; ... Bilateral central retinal artery occlusion in Wegeners granulomatosis and α1 antitrypsin deficiency ...
more infohttp://bjo.bmj.com/content/86/4/476.1

Carotid Artery Injuries
     Summary Report | CureHunterCarotid Artery Injuries Summary Report | CureHunter

THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS ... Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; ... and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473) ... Carotid; Injuries, Carotid Artery; Artery Injuries, Carotid; Artery Injury, Carotid; Artery Trauma, Carotid; Carotid ...
more infohttp://www.curehunter.com/public/keywordSummaryD020212-Carotid-Artery-Injuries.do

Penetrating carotid artery injuries treated by an urgent endovascular stent technique: report of two cases.Penetrating carotid artery injuries treated by an urgent endovascular stent technique: report of two cases.

Penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures ... Carotid artery injuries caused by blunt traumaAnn SurgYear: 198019274777406566. 3. Roon AJ,Christensen N. Evaluation and ... Zone II is the most common site of carotid artery injury, where there is often a tendency for the hematoma to be compressed and ... Penetrating Carotid Artery Injuries Treated by an Urgent Endovascular Stent Technique: Report of Two Cases ...
more infohttp://www.biomedsearch.com/nih/Penetrating-Carotid-Artery-Injuries-Treated/22111076.html

Carotid artery injury from an airgun pellet: a case report and review of the literature.Carotid artery injury from an airgun pellet: a case report and review of the literature.

Modern models, though less lethal, are still capable of inflicting serious or life threatening injuries. Current United Kingdom ... Carotid Artery Injuries / etiology, surgery*. Carotid Artery, External / surgery*. Humans. Male. Wounds, Gunshot / ... Carotid artery injury from an airgun pellet: a case report and review of the literature ... it was clear that the patient had Horners syndrome from injury to the left cervical sympathetic chain and carotid arteries. ...
more infohttp://www.biomedsearch.com/nih/Carotid-artery-injury-from-airgun/19149904.html

Bilateral blunt carotid artery injury: A case report and review of the literatureBilateral blunt carotid artery injury: A case report and review of the literature

A 22-year-old man sustained a strangulation-type injury to the neck, with bilateral blunt carotid artery injuries detected on ... Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging ... We report a case of bilateral internal carotid artery (ICA) injury due to strangulation. At presentation there was no ... 2. Kerby J, May A, Gomez C, Rue L. Treatment of bilateral blunt carotid injury using percutaneous angioplasty and stenting: ...
more infohttp://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0038-23612013000200011&lng=pt&nrm=iso

Bilateral blunt carotid artery injury: A case report and review of the literatureBilateral blunt carotid artery injury: A case report and review of the literature

A 22-year-old man sustained a strangulation-type injury to the neck, with bilateral blunt carotid artery injuries detected on ... Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging ... We report a case of bilateral internal carotid artery (ICA) injury due to strangulation. At presentation there was no ... 2. Kerby J, May A, Gomez C, Rue L. Treatment of bilateral blunt carotid injury using percutaneous angioplasty and stenting: ...
more infohttp://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0038-23612013000200011&lng=en&nrm=iso

Cureus | Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base SurgeryCureus | Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery

... arterial bleeding was encountered near the right internal carotid artery (ICA). Durable hemostasis could not be achieved with ... Arterial injuries, although serious, are not always catastrophic. Critical steps are immediate recognition of bleeding, ... Given the presence of good collateral flow through the anterior and posterior communicating arteries, the right ICA was ... Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa ...
more infohttps://www.cureus.com/articles/20767-management-of-noncatastrophic-internal-carotid-artery-injury-in-endoscopic-skull-base-surgery

Carotid artery injuries | definition of Carotid artery injuries by Medical dictionaryCarotid artery injuries | definition of Carotid artery injuries by Medical dictionary

What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean? ... Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. ... common carotid artery. (redirected from Carotid artery injuries). Also found in: Dictionary, Thesaurus, Encyclopedia. com·mon ... Carotid artery injuries , definition of Carotid artery injuries by Medical dictionary https://medical-dictionary. ...
more infohttps://medical-dictionary.thefreedictionary.com/Carotid+artery+injuries

Primary Repair vs Ligation for Carotid Artery Injuries<...Primary Repair vs Ligation for Carotid Artery Injuries<...

"Primary Repair vs Ligation for Carotid Artery Injuries",. abstract = "The morbidity and mortality of carotid arterial injuries ... Ledgerwood, A. M., Mullins, R., & Lucas, C. E. (1980). Primary Repair vs Ligation for Carotid Artery Injuries. Archives of ... Ledgerwood, AM, Mullins, R & Lucas, CE 1980, Primary Repair vs Ligation for Carotid Artery Injuries, Archives of Surgery, vol ... Ledgerwood, Anna M. ; Mullins, Richard ; Lucas, Charles E. / Primary Repair vs Ligation for Carotid Artery Injuries. In: ...
more infohttps://ohsu.pure.elsevier.com/en/publications/primary-repair-vs-ligation-for-carotid-artery-injuries-2

2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent | Journal of Cardiovascular...2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent | Journal of Cardiovascular...

A carotid artery injury model was performed in 8 wild-type and 8 CRP2-deficient (CRP2-/-) mice; the right carotid artery wall ... 2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent. ... of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury ... SNR and CNR of the injured right compared to the non injured left carotid artery was significantly increased (p , 0.001) both ...
more infohttps://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-10-S1-A394

Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury | CirculationDiet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury | Circulation

Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury. Hiroyuki Morita ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ...
more infohttp://circ.ahajournals.org/content/103/1/133

Craniocerebral trauma, Carotid artery injury with dissection, traumatic perforation of GI tract, pulmonary artery injury,...Craniocerebral trauma, Carotid artery injury with dissection, traumatic perforation of GI tract, pulmonary artery injury,...

Craniocerebral trauma, Carotid artery injury with dissection, traumatic perforation of GI tract, pulmonary artery injury, ... Craniocerebral trauma, Carotid artery injury with dissection, traumatic perforation of GI tract, pulmonary artery injury, ... Craniocerebral trauma, Carotid artery injury with dissection, traumatic perforation of GI tract, pulmonary artery injury, ... Pulmonary artery injuries are exceptionally reported in CT analysis; they are indicative of a violent mechanism. ...
more infohttps://www.imaios.com/cn/e-Cases/node_5661/node_55373/Craniocerebral-trauma-Carotid-artery-injury-with-dissection-traumatic-perforation-of-GI-tract-pulmonary-artery-injury-Chance-fracture

NAVER Academic | Application of liposomes incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid...NAVER Academic | Application of liposomes incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid...

... which are expressed on vessel walls with injury. In vitro experiments confirmed the accumulation of doxorubicin as a ... Application of liposomes incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury. ... The role of carotid angioplasty and stenting in carotid revascularization. Neurol Res. Vol. 27. 5358 (2005) Koebbe C.J. et al. ... Frequency and management of recurrent stenosis after carotid artery stent implantation. J Neurosurg. Vol. 102. 2937 (2005) Levy ...
more infohttp://academic.naver.com/article.naver?doc_id=64839914

AID 1260415 - Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis...AID 1260415 - Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis...

Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis assessed as ...
more infohttps://pubchem.ncbi.nlm.nih.gov/bioassay/1260415

Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury |...Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury |...

... was introduced through the left external carotid artery and passed into the common carotid artery. Injury was induced by ... The external carotid artery was ligated, and the wound was closed. Uninjured right carotid arteries were used as controls. At ... Effect of Injury on GAPDH mRNA Expression. Northern analysis of RNA from uninjured and injured rat carotid arteries was used to ... Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury. Karen E. ...
more infohttp://atvb.ahajournals.org/content/17/9/1837

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation.  -...IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. -...

Carotid injury was performed in WT and IL-10 KO mice by wire injury method. (A-B) Mice were injected with Evans blue (0.5%) 2- ... Carotid injury was performed in WT and IL-10 KO mice by wire injury method for 28 days. (A-B) 24h prior to euthanasia, BrdU (30 ... C-D) For morphometric analysis, 28 days after injury carotid artery were isolated and neo-intimal hyperplasia was measured by ... C) ET and H&E staining of carotid artery sections on 28 days post-injury visualized neo-intimal thickening. Representative ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/26808574

Upregulation of Basement Membrane-Degrading Metalloproteinase Secretion After Balloon Injury of Pig Carotid Arteries |...Upregulation of Basement Membrane-Degrading Metalloproteinase Secretion After Balloon Injury of Pig Carotid Arteries |...

... a pig carotid artery model in which both deep medial tears and stretch-induced injury occur was used. Both types of injury are ... In the rat carotid artery, injury increases tissue levels of gelatinase B and activates gelatinase A,13 19 further implicating ... Response to Balloon Injury in the Pig Carotid Artery. As described previously,23 balloon inflation caused dilatation in all ... Sections of a carotid artery harvested 7 days after balloon injury were hybridized with 106 cpm of gelatinase B antisense RNA ( ...
more infohttp://circres.ahajournals.org/content/79/6/1177

CAROTID ARTERY OCCLUSION DUE TO NONPENETRATING INJURY : Journal of Trauma and Acute Care SurgeryCAROTID ARTERY OCCLUSION DUE TO NONPENETRATING INJURY : Journal of Trauma and Acute Care Surgery

Home , May 1967 - Volume 7 - Issue 3 , CAROTID ARTERY OCCLUSION DUE TO NONPENETRATING INJURY ... THE SPECTRUM OF BLUNT INJURY TO THE CAROTID ARTERY: A MULTICENTER PERSPECTIVE ... Blunt Cerebrovascular Injuries: Does Treatment Always Matter? * Blunt cerebrovascular injuries: Redefining screening criteria ... Blunt cerebrovascular injury screening with 64-channel multidetector computed tomography: More slices finally cut it ...
more infohttps://journals.lww.com/jtrauma/Citation/1967/05000/CAROTID_ARTERY_OCCLUSION_DUE_TO_NONPENETRATING.1.aspx

Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery |...Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery |...

Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery ...
more infohttp://jpet.aspetjournals.org/content/early/2008/12/31/jpet.109.157065

Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits. - Semantic ScholarCarotid artery stents for blunt cerebrovascular injury: risks exceed benefits. - Semantic Scholar

CONCLUSIONS Patients who have carotid stents placed for blunt carotid pseudoaneurysms have a 21% complication rate and a ... underwent carotid stent placement. There were 4 complications in patients undergoing carotid stent placement: 3 strokes and 1 ... 8 patients had poststent carotid occlusion despite having received concurrent anticoagulation therapy. Carotid occlusion rates ... HYPOTHESIS Carotid stenting is safe and effective for blunt CAIs. DESIGN Analysis of a prospective database of all patients ...
more infohttps://www.semanticscholar.org/paper/Carotid-artery-stents-for-blunt-cerebrovascular-Cothren-Moore/3d3457de6d28d24c1c7a3c2f8049cdcfd2fc3de2

Severe cranioencephalic injuries, Carotid artery dissection, Aspiration pneumonia, Pelvic fracture	Severe cranioencephalic injuries, Carotid artery dissection, Aspiration pneumonia, Pelvic fracture

Severe cranioencephalic injuries, Carotid artery dissection, Aspiration pneumonia, Pelvic fracture Imagens de casos de ... frequently occurs following severe facial injury due to blood inhalation++).. - Suspect urethral injury in the event of a ... No urological or vascular complications but very strong suspicion of urethral injury given the significant displacement of the ... The subpetrous portion of the internal carotid and its intracavernous portion are the most vulnerable sites.. - Inhalation ...
more infohttps://www.imaios.com/br/e-Cases/Canais-publicos/Imagens-de-casos-de-emergencia/Severe-cranioencephalic-injuries-Carotid-artery-dissection-Aspiration-pneumonia-Pelvic-fracture

Life in Israel: Hockey injury - cut carotid artery (video)Life in Israel: Hockey injury - cut carotid artery (video)

Hockey injury - cut carotid artery (video) sorry, but this is just one of those clips I cannot stop myself fro putting up. This ... freak accident led to Zednicks carotid artery being cut by a skate.... ...
more infohttp://lifeinisrael.blogspot.com/2008/02/hockey-injury-cut-carotid-artery-video.html

Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid...Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid...

... bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in ... RESULTS: Cerebral ACT and BHB levels increased significantly in Group T after 30min of carotid occlusion (time 0). The highest ... CONCLUSIONS: The partial transient acute global brain ischemia induced by the bilateral carotid occlusion in Wistar rats ... ischemia/reperfusion through an experimental model of brain ischemia induced by simple occlusion of common carotid arteries ( ...
more infohttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502007000200009&lng=en&nrm=iso&tlng=en
  • METHODS: After Institutional Review Board approval, all penetrating neck injuries assessed during a 16-month period were prospectively evaluated at a Level I trauma center. (elsevier.com)
  • BACKGROUND: The optimal management strategy for patients sustaining penetrating neck injury without an urgent indication for operative exploration remains controversial. (elsevier.com)
  • In this study we investigated whether the use of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury and whether it would facilitate the detection of impaired ECM formation in CRP2-/- mice. (biomedcentral.com)
  • Here we report that in a mouse model of carotid denudation, IL-10 knock-out mice (IL-10KO) displayed significantly delayed Re-endothelialization and enhanced neo-intimal growth compared to their WT counterparts. (nih.gov)
  • A penetrating trauma occurring in the neck can cause severe complications such as hemorrhage as the result of vascular injury, spinal cord injury, respiratory obstruction, and sepsis from esophageal injury. (biomedsearch.com)
  • In certain cases, the endoscopic approach can preclude obtaining proximal control of the offending vascular injury and due to anatomic and technical constraints. (cureus.com)
  • Smooth muscle cell proliferation and extracellular matrix (ECM) synthesis/turnover are thought to play an important role in vessel wall repair after vascular injury. (biomedcentral.com)
  • Preliminary evaluation of the carotid wall thickening seem to confirm our MRI findings and suggests that targeted deletion of CRP2 in mice might lead to a reduced vessel wall thickening and thus to a reduced restenosis after vascular injury. (biomedcentral.com)
  • In this study, we demonstrate the successful use of molecular MRI for the non-invasive assessment of alterations in the vessel wall after vascular injury in a mouse model of impaired smooth muscle cell proliferation and ECM formation. (biomedcentral.com)
  • Inflammatory cells are likely contributors in the host response to vascular injury, via cytokines and chemokines secretion, including TNF-alpha (TNF). (nih.gov)
  • Vascular injury and ReEndo was examined on day 7 by Evans blue perfusion method. (nih.gov)
  • Blunt vertebral vascular injury in trauma patients: ATLS® recommendations and review of current evidence. (semanticscholar.org)
  • Objectives- We have previously reported that vascular injury or treatment of cultured vascular smooth muscle cells with platelet-derived growth factor-BB (PDGF-BB) or fibroblast growth factor-2 (FGF2) increases the levels of protein tyrosine phosphatase (PTP)1B. (ahajournals.org)
  • Conclusions- PTP1B suppresses cell proliferation and motility in cultured smooth muscle cells treated with PDGF-BB or FGF2, and the phosphatase plays a counter-regulatory role in vascular injury-induced cell proliferation and neointima formation. (ahajournals.org)
  • Migration and proliferation of smooth muscle cells are of critical importance in neointima formation and remodeling occurring in response to vascular injury. (ahajournals.org)
  • 7,8 These studies indicate that PDGF and FGF are important mediators of neointima formation in models of vascular injury. (ahajournals.org)
  • 1 Hence, 1 of the aims of the present study was to test the hypothesis that 2-ME can inhibit vascular injury-induced neointima formation. (ahajournals.org)
  • This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by cardiovascular magnetic resonance (CMR) using a T2-weighted short-tau inversion recovery sequence (T2-STIR). (springer.com)
  • We have previously shown that IL-10 inhibits TNF and other inflammatory mediators produced in response to cardiovascular injuries. (nih.gov)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts. (wikipedia.org)
  • Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
  • Furthermore, balloon injury or treatment in vivo with PDGF also induces PDGF receptor tyrosyl phosphorylation in vascular smooth muscle, 6,9 a finding consistent with experiments in vitro. (ahajournals.org)
  • Trivedi RA, Mallawarachi C, King-Im JM et al (2006) Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. (springer.com)
  • Caspase-3 cleavage assay and fluorescence-activated cell-sorting (FACS) analysis showed no evidence of apoptosis in 2-ME-treated SMCs, and TUNEL staining in carotid segments showed no evidence of 2-ME-induced apoptosis in vivo. (ahajournals.org)
  • Accordingly, unlike the situation in zone II of the neck, where the proximal and distal control of blood vessels can be easily achieved, angiography should be performed in cases of penetrating injury occurring in zones I and III. (biomedsearch.com)
  • Grade I and II injuries are of particular concern and require follow-up angiography owing to the risk of pseudo-aneurysm formation despite heparin therapy. (scielo.org.za)
  • Methods and Results- Treatment of cultured cells with adenovirus expressing PTP1B decreased PDGF-BB- or FGF2-induced cell motility and blocked PDGF-BB- or FGF2-induced proliferation, whereas expression of dominant negative PTP1B (C215S-PTP1B) uncovered the motogenic effect of subthreshold levels of PDGF-BB or FGF2, increased neointimal and medial cell proliferation, and induced neointimal enlargement after balloon injury. (ahajournals.org)
  • Its delivery was controlled via the affinity between SLX and E-selectin proteins, which are expressed on vessel walls with injury. (naver.com)
  • We experienced some cases with externally penetrating injuries in neck zone II in which the patients were confirmed to have the presence of large vessel injuries in neck zones I and III. (biomedsearch.com)
  • In cases of penetrating injury occurring in zones I and III of the neck, the direct control of blood vessels is difficult. (biomedsearch.com)
  • These results demonstrate that the process of extracellular matrix breakdown by MMPs after balloon catheter-induced injury is controlled by a tightly regulated temporal response by the genes responsible for the production of these enzymes and their inhibitor and by post-translational activation of the proenzymes. (ahajournals.org)
  • gelatinase B) was induced after balloon catheter injury during the period of migration of smooth muscle cells from the media to the intima. (ahajournals.org)
  • Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. (springer.com)
  • Penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures in the neck. (biomedsearch.com)
  • Medial smooth muscle cell proliferation begins immediately after injury and peaks early, reaching a maximum at 2 days. (ahajournals.org)
  • The current study was designed to test the hypothesis that PTP1B attenuates PDGF- or FGF-induced motility and proliferation of cultured cells, as well as neointima formation in injured rat carotid arteries. (ahajournals.org)
  • 2 Several reports indicate that injury-induced movement of smooth muscle cells from media to intima and the proliferation of smooth muscle cells in intima are significantly reduced by pharmacological antagonists of the function or availability of PDGF or FGF2. (ahajournals.org)
  • Given the presence of good collateral flow through the anterior and posterior communicating arteries, the right ICA was sacrificed by coil embolization. (cureus.com)
  • It extends at the middle stage of the base of the skull with fracture of the right temporal condylar fossa, the greater wing of the right sphenoid bone, the walls of the sphenoid canal and the left carotid canal and finally with an extralabyrinthic fracture of the left petrous bone with no damage to the ossicular chain. (imaios.com)
  • Despite having a sensitivity of 50 - 68%, it is a popular diagnostic screening modality because of fast scanning times, and has the added benefit of excluding multiple injuries in the polytrauma patient. (scielo.org.za)
  • None of the multi-contrast weighted sequences detected edema in the carotid artery with reasonable sensitivity or specificity. (springer.com)
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. (icd10data.com)
  • T2-STIR CMR allowed carotid artery wall edema detection and may therefore be a useful non-invasive diagnostic tool for determination of inflammatory activity in the carotid artery wall. (springer.com)
  • On the basis of these findings, carotid artery repair is recommended in all patients who are not comatose, have stable vital signs, and have technically reparable injuries. (elsevier.com)
  • Because homocysteine is known to exert a direct inhibitory effect on endothelial cell growth in vitro, we hypothesized that this effect contributes to the progression of atherosclerotic lesions initiated by endothelial damage caused by mechanical injury. (ahajournals.org)
  • No urological or vascular complications but very strong suspicion of urethral injury given the significant displacement of the symphyseal separation. (imaios.com)