Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
The vessels carrying blood away from the heart.
The nonstriated involuntary muscle tissue of blood vessels.
Penetrating wounds caused by a pointed object.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
The main artery of the thigh, a continuation of the external iliac artery.
Formation and development of a thrombus or blood clot in the blood vessel.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Wounds caused by objects penetrating the skin.
The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Radiography of blood vessels after injection of a contrast medium.
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
Disruption of structural continuity of the body as a result of the discharge of firearms.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The arterial blood vessels supplying the CEREBRUM.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Radiography of the vascular system of the brain after injection of a contrast medium.
A measurement of the thickness of the carotid artery walls. It is measured by B-mode ULTRASONOGRAPHY and is used as a surrogate marker for ATHEROSCLEROSIS.
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.
The first and largest artery branching from the aortic arch. It distributes blood to the right side of the head and neck and to the right arm.
Elements of limited time intervals, contributing to particular results or situations.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Injuries incurred during participation in competitive or non-competitive sports.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
Operative procedures for the treatment of vascular disorders.
The veins and arteries of the HEART.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Penetrating and nonpenetrating traumatic injuries to an extracranial or intracranial blood vessel that supplies the brain. This includes the CAROTID ARTERIES; VERTEBRAL ARTERIES; MENINGEAL ARTERIES; CEREBRAL ARTERIES; veins, and venous sinuses.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
Techniques for controlling bleeding.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Artery originating from the internal carotid artery and distributing to the eye, orbit and adjacent facial structures.
Multiple physical insults or injuries occurring simultaneously.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Application of a ligature to tie a vessel or strangulate a part.
The flow of BLOOD through or around an organ or region of the body.
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.
A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.
General or unspecified injuries involving the leg.
Benign paraganglioma at the bifurcation of the COMMON CAROTID ARTERIES. It can encroach on the parapharyngeal space and produce dysphagia, pain, and cranial nerve palsies.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Transient complete or partial monocular blindness due to retinal ischemia. This may be caused by emboli from the CAROTID ARTERY (usually in association with CAROTID STENOSIS) and other locations that enter the central RETINAL ARTERY. (From Adams et al., Principles of Neurology, 6th ed, p245)
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
The condition of an anatomical structure's being constricted beyond normal dimensions.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
An irregularly shaped venous space in the dura mater at either side of the sphenoid bone.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
Lesions formed within the walls of ARTERIES.
Agents that prevent clotting.
Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Pathologic deposition of calcium salts in tissues.

Endothelial implants inhibit intimal hyperplasia after porcine angioplasty. (1/784)

The perivascular implantation of tissue-engineered endothelial cells around injured arteries offers an opportunity to study fundamental vascular physiology as well as restore and improve tissue function. Cell source is an important issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the clinical applications of tissue-engineered grafts. We investigated the biological and immunological responses to endothelial cell xenografts and allografts in pigs 4 weeks after angioplasty of the carotid arteries. Porcine or bovine aortic endothelial cells were cultured within Gelfoam matrices and implanted in the perivascular space of 42 injured arteries. Both porcine and bovine endothelial cell grafts reduced the restenosis index compared with control by 54% and 46%, respectively. Perivascular heparin release devices, formulated to release heparin at twice the rate of release of heparan sulfate proteoglycan from endothelial cell implants, produced no significant reduction in the restenosis index. Endothelial cell implants also reduced occlusive thrombosis compared with control and heparin release devices. Host immune responses to endothelial implants were investigated by immunohistochemical examination of explanted devices and by immunocytochemistry of serum samples. The bovine cell grafts displayed infiltration of leukocytes, consisting primarily of lymphocytes, and caused an increase in antibodies detected in serum samples. Reduced cellular infiltration and no humoral response were detected in animals that received allografts. Despite the difference in immune response, the biological effects of xenografts or allografts did not differ significantly.  (+info)

Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. (2/784)

Prostacyclin (PGI2), a metabolite of arachidonic acid, has the vasoprotective effects of vasodilation, anti-platelet aggregation, and inhibition of smooth muscle cell proliferation. We hypothesized that an overexpression of endogenous PGI2 may accelerate the recovery from endothelial damage and inhibit neointimal formation in the injured artery. To test this hypothesis, we investigated in vivo transfer of the PGI2 synthase (PCS) gene into balloon-injured rat carotid arteries by a nonviral lipotransfection method. Seven days after transfection, a significant regeneration of endothelium was observed in the arteries transfected with a plasmid carrying the rat PCS gene (pCMV-PCS), but little regeneration was seen in those with the control plasmid carrying the lacZ gene (pCMV-lacZ) (percent luminal circumference lined by newly regenerated endothelium: 87. 1+/-6.9% in pCMV-PCS-transfected vessels and 6.9+/-0.2% in pCMV-lacZ vessels, P<0.001). BrdU staining of arterial segments demonstrated a significantly lower incorporation in pCMV-PCS-transfected vessels (7. 5+/-0.3% positive nuclei in vessel cells) than in pCMV-lacZ (50. 7+/-9.6%, P<0.01). Moreover, 2 weeks after transfection, the PCS gene transfer resulted in a significant inhibition of neointimal formation (88% reduction in ratio of intima/media areas), whereas medial area was similar among the groups. Arterial segments transfected with pCMV-PCS produced significantly higher levels of 6-keto-PGF1alpha, the main metabolite of PGI2, compared with the segments transfected with pCMV-lacZ (10.2+/-0.55 and 2.1+/-0.32 ng/mg tissue for pCMV-PCS and pCMV-placZ, P<0.001). In conclusion, this study demonstrated that an in vivo PCS gene transfer increased the production of PGI2 and markedly inhibited neointimal formation with accelerated reendothelialization in rat carotid arteries after balloon injury.  (+info)

Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation. (3/784)

The aim of this study was to evaluate whether vascular remodeling and neointimal thickening occur after balloon dilatation of the nonatherosclerotic rabbit carotid artery, and whether both processes are influenced by continuous perivascular delivery of L-arginine or the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). In the first experiment, histological and morphometric evaluation of arteries was performed at different time points after balloon dilatation: 10 minutes (n=7), and 1 (n=7), 2 (n=9), 3 (n=20), or 10 (n=5) weeks. Neointimal thickening progressively contributed to luminal narrowing for at least 10 weeks after angioplasty. During the first 2 weeks after dilatation, a significant decrease of the total vessel area was measured. Ten weeks after dilatation, both the neointimal and total vessel area were increased without further changing of the luminal area. In the second experiment, endothelial injured rabbits were randomly assigned to receive 2 weeks of continuous local perivascular physiological salt solution (n=6), L-arginine (n=8), or L-NAME (n=7), starting immediately after balloon dilatation (ie, local drug delivery during the first phase of the biphasic vascular remodeling process). Perivascular L-arginine delivery significantly reduced the neointimal area, despite an increased number of neointimal Ki-67-positive smooth muscle cells. Both the luminal area and total vessel area were significantly increased. Serum L-arginine levels remained unchanged. L-NAME administration had no effect on the neointimal area, nor on the luminal and total vessel area. Neointimal formation and biphasic vascular remodeling occur after experimental balloon dilatation of the nonatherosclerotic rabbit carotid artery, and can be influenced by continuous local perivascular delivery of L-arginine.  (+info)

TIMP-4 is regulated by vascular injury in rats. (4/784)

The role of basement membrane-degrading matrix metalloproteinases (MMPs) in enabling vascular smooth muscle cell migration after vascular injury has been established in several animal models. In contrast, the role of their native inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), has remained unproven despite frequent coregulation of MMPs and TIMPs in other disease states. We have investigated the time course of expression and localization of TIMP-4 in rat carotid arteries 6 hours, 24 hours, 3 days, 7 days, and 14 days after balloon injury by in situ hybridization, immunohistochemistry, and Western blot analysis. TIMP-4 protein was present in the adventitia of injured carotid arteries from 24 hours after injury. At 7 and 14 days after injury, widespread immunostaining for TIMP-4 was observed throughout the neointima, media, and adventitia of injured arteries. Western blot analysis confirmed the quantitative increase in TIMP-4 protein at 7 and 14 days. In situ hybridization detected increased expression of TIMP-4 as early as 24 hours after injury and a marked induction in neointimal cells 7 days after injury. We then studied the effect of TIMP-4 protein on the migration of smooth muscle cells through a matrix-coated membrane in vitro and demonstrated a 53% reduction in invasion of rat vascular smooth muscle cells. These data and the temporal relationship between the upregulation of TIMP-4, its accumulation, and the onset of collagen deposition suggest an important role for TIMP-4 in the proteolytic balance of the vasculature controlling both smooth muscle migration and collagen accumulation in the injured arterial wall.  (+info)

The role of alpha and beta platelet-derived growth factor receptor in the vascular response to injury in nonhuman primates. (5/784)

Restenosis remains a significant clinical problem associated with mechanical interventional procedures for arterial revascularization or repair, including coronary angioplasty and stenting. Studies with rodents have established that platelet-derived growth factor (PDGF), a potent chemotactic and mitogenic agent for vascular smooth muscle cells, is a key mediator of lesion formation after vascular injury. To further explore this hypothesis in a more clinically relevant model, neutralizing monoclonal antibodies (mAbs) were used to examine the effect of selective inhibition of alpha or beta PDGF receptor (PDGFR) on neointima formation in nonhuman primates. Carotid arteries were injured by surgical endarterectomy and femoral arteries by balloon catheter dilatation. Immunostaining revealed that both injuries induced cell proliferation and the upregulation of beta PDGFR but not alpha PDGFR. By 7 days after injury, beta PDGFR staining was limited to the luminal region of the media, the small areas of neointima, and the adventitia. Nearly all bromodeoxyuridine-positive cells were found in these regions as well. After 30 days, a concentric neointima that stained strongly for beta PDGFR had formed in the carotid and femoral arteries. Treatment of baboons with anti-beta PDGFR mAb 2A1E2 for 6 days after injury reduced the carotid artery and femoral artery lesion sizes by 37% (P<0.05) and 48% (P<0.005), respectively, when measured at 30 days. Under the same conditions, treatment with anti-alpha PDGFR mAb 2H7C5 had no effect. These findings suggest that PDGF mediates neointima formation through the beta PDGFR, and that antagonism of this pathway may be a promising therapeutic strategy for reducing clinical restenosis.  (+info)

Glucocorticoid resistance caused by reduced expression of the glucocorticoid receptor in cells from human vascular lesions. (6/784)

Mechanisms that control the balance between cell proliferation and death are important in the development of vascular lesions. Rat primary smooth muscle cells were 80% inhibited by low microgram doses of hydrocortisone (HC) and 50% inhibited by nanogram concentrations of transforming growth factor-beta1 (TGF-beta1), although some lines acquired resistance in late passage. However, comparable doses of HC, or TGF-beta1, failed to inhibit most human lesion-derived cell (LDC) lines. In sensitive LDC, HC (10 microg/mL) inhibited proliferation by up to 50%, with obvious apoptosis in some lines, and TGF-beta1 inhibited proliferation by more than 90%. Collagen production, as measured by [3H]proline incorporation or RIA for type III pro-collagen, was either unaffected or increased in the LDCs by HC. These divergent responses between LDC lines were partially explained by the absence of the glucocorticoid receptor (GR) and heat shock protein 90 mRNA in 10 of 12 LDC lines, but the presence of the mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II. Western blot analysis confirmed the absence of the GR protein in cells lacking GR mRNA. Immunohistochemistry of human carotid lesions showed high levels of GR in the tunica media, but large areas lacking GR in the fibrous lesion. Considering the absence of the GR in most lines, the effects of HC may be elicited through the mineralocorticoid receptor. Functional resistance to the antiproliferative and antifibrotic effects of HC may contribute to excessive wound repair in atherosclerosis and restenosis.  (+info)

Apoptosis and Bcl-xs in the intimal thickening of balloon-injured carotid arteries. (7/784)

We performed balloon injury in the rat carotid artery and identified intimal thickening after injury. Balloon-injured carotid arteries showed maximum thickness of the neointima on the 14th day before complete endothelial cell regeneration. In this lesion we identified apoptosis of vascular smooth muscle cells (VSMCs) by in situ DNA labelling and electron microscopy in the neointima on the 14th day after injury. mRNA expression levels of bcl-2, bax, bcl-x, p53 and caspase-1 were determined by the reverse transcriptase-polymerase chain reaction method both in injured and uninjured carotid arteries. Neither bcl-2 nor bcl-xl mRNA expression was detected in either injured or uninjured arteries, whereas bax and p53 mRNA expression was identified and their mRNA levels were not altered after balloon injury. In contrast, both bcl-xs and caspase-1 mRNA was detected and was markedly induced only in the injured carotid artery. Positive staining for immunoreactive Bcl-x was observed specifically in the injured arterial wall and co-localized with positive staining of nuclei identified by in situ DNA labelling. We conclude that two opposite cellular responses, VSMC proliferation and apoptosis, exist together in the neointima of the rat carotid artery after balloon injury, and selective induction of Bcl-xs expression is a key regulator of VSMC apoptosis in the process of vascular remodelling.  (+info)

Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. (8/784)

Using the rat balloon catheter denudation model, we examined the role of transforming growth factor-beta (TGF-beta) isoforms in vascular repair processes. By en face in situ hybridization, proliferating and quiescent smooth muscle cells in denuded vessels expressed high levels of mRNA for TGF-beta1, TGF-beta2, TGF-beta3, and lower levels of TGF-beta receptor II (TGF-betaRII) mRNA. Compared with normal endothelium, TGF-beta1 and TGF-beta2, as well as TGF-betaRII, mRNA were upregulated in endothelium at the wound edge. Injected recombinant soluble TGF-betaRII (TGF-betaR:Fc) localized preferentially to the adventitia and developing neointima in the injured carotid artery, causing a reduction in intimal lesion formation (up to 65%) and an increase in lumen area (up to 88%). The gain in lumen area was largely due to inhibition of negative remodeling, which coincided with reduced adventitial fibrosis and collagen deposition. Four days after injury, TGF-betaR:Fc treatment almost completely inhibited the induction of smooth muscle alpha-actin expression in adventitial cells. In the vessel wall, TGF-betaR:Fc caused a marked reduction in mRNA levels for collagens type I and III. TGF-betaR:Fc had no effect on endothelial proliferation as determined by reendothelialization of the denuded rat aorta. Together, these findings identify the TGF-beta isoforms as major factors mediating adventitial fibrosis and negative remodeling after vascular injury, a major cause of restenosis after angioplasty.  (+info)

Rat carotid artery balloon injury model / David A. Tulis -- Histological and morphometric analyses for rat carotid balloon injury model / David A. Tulis -- Plaque rupture model in mice / Takeshi Sasaki, Kae Nakamura and Masafumi Kuzuya -- Immunostaining of mouse atherosclerotic lesions / Hong Lu, Debra L. Rateri and Alan Daugherty -- Surgical animal model of ventricular hypertrophy / Giuseppe Marano and Alberto U. Ferrari -- Animal models of hypertension / Brett M. Mitchell, Thomas Wallerath and Ulrich Förstermann -- Rat models of cardiac insulin resistance / Sanjoy Ghosh, Brian Rodrigues and Jun Ren -- The Isolated, perfused pseudo-working heart model / Gary J. Grover and Rajni Singh -- Altering and analyzing glucose metabolism in perfused hearts of transgenic mice / Rajakumar V. Donthi and Paul N. Epstein -- Methods in the evaluation of cardiovascular renin angiotensin aldosterone activation and oxidative stress / Camila Manrique -- Detection and quantification of apoptosis in the vasculature ...
Mitoxantrone suppresses vascular smooth muscle cell (VSMC) proliferation and balloon injury-induced neointima formation: An in vitro and in vivo study
Discussion. Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging modalities and management options, the morbidity and mortality associated with BCI is over 30%, largely due to stroke.[1] Bilateral injuries to the ICA are exceptionally rare, with experience limited to case reports only.[2]. A high index of suspicion is essential in detecting this often clinically occult injury. Biffl et al.[3] have shown that aggressive screening using the Denver screening criteria (Table 1) to decide on the need for investigation[4] has increased the detection rate for BCI from 0.1% to 0.86%. In addition, they showed an improvement in neurological outcome in asymptomatic BCI patients who were anticoagulated.. Biffls grading system based on investigative angiographic findings has management and prognostic implications outlined- in Table 2.[4] Grade I and II injuries are of particular concern and require follow-up angiography owing to the ...
METHODS AND RESULTS: PI3K/p110α was inhibited by treatment with the small molecule inhibitor PIK75 or a specific siRNA. Arterial thrombosis, neointima formation, and re-endothelialization were studied in a murine carotid artery injury model. Proliferation and migration of human vascular smooth muscle cell (VSMC) and endothelial cell (EC) were assessed by cell number and Boyden chamber, respectively. Endothelial senescence was evaluated by the β-galactosidase assay, endothelial dysfunction by organ chambers for isometric tension. Arterial thrombus formation was delayed in mice treated with PIK75 when compared with controls. PIK75 impaired arterial expression and activity of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1); in contrast, plasma clotting and platelet aggregation did not differ. In VSMC and EC, PIK75 inhibited expression and activity of TF and PAI-1. These effects occurred at the transcriptional level via the RhoA signalling cascade and the transcription factor ...
Here we provide the first evidence that 2-ME protects against injury-induced neointima formation in rats and arrests growth of human aortic SMCs via double blockade of the cell cycle. We demonstrate that 2-ME: (1) arrests proliferating SMCs in G0/G1 and G2/M-phases; (2) inhibits the signaling pathways ERK1/2 and Akt; (3) inhibits the expression and activation of key proteins responsible for the progression of cells into the DNA replicating phase (such as cyclin D1 expression and cdk4 activity associated with it and pRb phosphorylation); (4) upregulates the expression of the cdk inhibitor p27, suggesting that 2-ME can block HASMCs in G0/G1 phase via 2 different mechanisms; (5) inhibits cyclin B1 expression and cdk1 activity associated with it (essential for G2-to-M progression); (6) inhibits tubulin polymerization, a critical process in cell division; (7) induces COX-2 expression (known to mediate antiproliferative actions in SMCs); and (8) does not induce apoptosis, suggesting that the growth ...
Ji and colleagues describe a dynamic profile of miRNA changes several days after injury of the rat internal carotid artery.11 They report 113 differentially expressed miRNAs of the 140 detectable in arterial tissue. Indicative of a chronic response, 102 miRNA species continue to be expressed at significantly different levels 28 days after injury. After confirming the differential expression of the most significantly altered miRNAs by real-time PCR and northern blotting, they focus on miR-21 as the most robustly induced miRNA to determine its biological significance. The selection of miR-21 is also notable because it has recently been found to promote tumor growth implicating its role in cell proliferation, a hallmark of restenotic neointimal lesions.12. Returning to the original carotid injury model, the authors tested the biological effect of knocking down miR-21 using modified antisense oligonucleotides locally delivered in a special pluronic gel. They confirm localization of the ...
Growing evidence in clinical studies suggests that ubiquitin systems are greatly related to the progression of atherosclerosis, particularly in relation to inflammation and cell proliferation. However, there were few reports referred to molecular mechanisms of vascular remodeling related to ubiquitin systems. NF-κB is an important transcriptional factor which plays central roles in pathogenesis of atherosclerosis. Thus, in this study, we focused on CYLD which is a NF-κB-related deubiquitinating enzyme and may be a therapeutic target of tumor in cancer research. From Northern blot and immunohistology, CYLD was endogenously expressed in vascular endothelial cells (EC) and smooth muscle cells (VSMC). Interestingly, the treatment of TNF-α significantly increased CYLD expression in EC and VSMC. CYLD was markedly induced in the neointima of the balloon-injured carotid arteries, and was also present in atherosclerotic lesions from human carotid arteries. Thus, the expression of CYLD could be ...
In the present study, we showed that overexpression of Mst1 induced VSMC apoptosis in vitro and in vivo and suppressed neointimal formation in balloon-injured artery. This is the first report examining the function of Mst1 in VSMCs and in balloon-injured artery. A recent study reported that cardiac-specific overexpression of Mst1 causes dilated cardiomyopathy,17 suggesting that apoptosis of cardiac myocytes impairs cardiac function. However, overexpression of Mst1 in injured artery has anti-proliferative effect by stimulating apoptosis, which may be used as a therapeutic tool for vascular proliferative lesion such as in-stent restenosis.. Numerous animal models of acute balloon injury of artery have documented apoptotic VSMC death. Several studies demonstrated that balloon injury of vessels induces two waves of VSMC apoptosis. The first wave of apoptosis occurred in the media within hours of the injury.5 The second wave occurs at much later times after injury (days to weeks). VSMC accumulation ...
Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. No sex-based differences were observed. Mechanistic studies suggested that Fn-EDA mediates integrin- and TLR4-dependent proliferation and migration through activation of FAK/Src and Akt1/mTOR signaling, respectively. Specific deletion of Fn-EDA in SMCs, but not in endothelial cells, reduced intimal hyperplasia and suppressed the SMC synthetic phenotype concomitant with ...
Aberrant EC recovery is inversely related to neointima formation during atherosclerosis and postinjury restenosis. Our current study revealed ADAMTS-7 as a potent inhibitor of endothelial recovery in response to injury. Using Adamts7-/- mice and injury models, we uncovered that, in addition to the suppression of VSMC migration, ADAMTS-7 deficiency also promoted re-endothelialization and completely blocked subsequent neointima formation. ADAMTS-7 inhibition, therefore, is a promising dual-effect target for both atherosclerosis and restenosis after PCI.. The ADAMTS-7 locus was identified to have a strong association with coronary atherosclerotic disease14,15 and was rather involved in the formation of atherosclerotic plaques in comparison with atherothrombotic events. However, the underlying mechanism is not yet understood. In the current phenotype screening assay, we did not observe difference regarding lipid metabolism. As shown in Table IV in the online-only Data Supplement, without a ...
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R.S.M.P., R.A.M.P. போட்டுக்கொண்டாலும் அவர்களுக்கு உரிய மருத்துவ கவுன்சிலில் பதிவு செய்திருக்க மாட்டார்கள். பதிவு செய்ய வேண்டுமென்றால் அவர்கள் பட்டம் பெற்றிருக்க வேண்டும். பக்கத்தில் உள்ள அச்சகத்திலோ (இப்போது கம்யூட்டர் செண்டரில் ) ஒரு காகிதத்தில் அச்சடித்து பிரேம் போட்டு மாட்டிக் கொண்டு தொழில் செய்பவர்களை காவல்துறை அவ்வப்போது கைது செய்து கொண்டேதான் இருக்கிறார்கள். I M Aவும் இது ...
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Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean?
TY - JOUR. T1 - Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. AU - Sibinga, Nicholas E S. AU - Foster, Lauren C.. AU - Hsieh, Chung Ming. AU - Perrella, Mark A.. AU - Lee, Wen Sen. AU - Endege, Wilson O.. AU - Sage, E. Helene. AU - Lee, Mu En. AU - Haber, Edgar. PY - 1997. Y1 - 1997. N2 - To identify genes involved in vascular remodeling, we applied differential mRNA display analysis to the rat carotid artery balloon injury model. One polymerase chain reaction product showing increased expression at days 2 to 14 after vascular injury was nearly identical to the mouse α1 chain of type VIII collagen, a heterotrimeric short-chain collagen of uncertain function expressed by a limited number of cell types. By Northern analysis, expression of both chains of the type VIII collagen heterotrimer increased: collagen α1 (VIII) mRNA expression was almost 4-fold higher than control by 7 days after vascular injury, and collagen α2 (VIII) mRNA expression reached ...
TY - JOUR. T1 - Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury.. AU - Yoshida, Tadashi. AU - Yamashita, Maho. AU - Horimai, Chihiro. AU - Hayashi, Matsuhiko. PY - 2014. Y1 - 2014. N2 - Krüppel-like factor 4 (Klf4) is involved in a variety of cellular functions by activating or repressing the transcription of multiple genes. Results of previous studies showed that tamoxifen-inducible global deletion of the Klf4 gene in mice accelerated neointimal formation following vascular injury, in part via enhanced proliferation of smooth muscle cells (SMCs). Because Klf4 is also expressed in non-SMCs including endothelial cells (ECs), we determined if Tie2 promoter-dependent deletion of Klf4 in ECs and hematopoietic cells affected injury-induced neointimal formation. Klf4 conditional knockout (cKO) mice were generated by breeding Tie2-Cre mice and Klf4 floxed mice, and their phenotype was analyzed after carotid ligation ...
Objective-The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial walls response to injury. The identification and characterization of the NF-kB essential modulator- binding domain (NBD) peptide, which can block the activation of the IkB kinase complex, have provided an opportunity to selectively abrogate the inflammation-induced activation of NF-kB. The aim of the present study was to evaluate the effect of the NBD peptide on neointimal formation.,br,,/br, Methods and Results-In the rat carotid artery balloon angioplasty model, local treatment with the NBD peptide (300 microg/site) significantly reduced the number of proliferating cells at day 7 (by 40%; P,0.01) and reduced injury-induced neointimal formation (by 50%; P,0.001) at day 14. These effects were associated with a significant reduction of NF-kB activation and monocyte chemotactic protein-1 expression in the carotid arteries of rats treated with the peptide. In addition, the NBD peptide (0.01 to 1 micromol/L) ...
TY - JOUR. T1 - Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury. AU - Wang, Ying. AU - Zhao, Beilei. AU - Zhang, Yi. AU - Tang, Zhihui. AU - Shen, Qiang. AU - Zhang, Youyi. AU - Zhang, Weizhen. AU - Du, Jie. AU - Chien, Shu. AU - Wang, Nanping. PY - 2012/4. Y1 - 2012/4. N2 - BACKGROUND AND PURPOSE The transcription factor, Krüppel-like factor 4 (KLF4), plays an important role in regulating the proliferation of vascular smooth muscle cells. This study aimed to examine the effect of rapamycin on the expression of KLF4 and the role of KLF4 in arterial neointimal formation. EXPERIMENTAL APPROACH Expression of KLF4 was monitored using real-time PCR and immunoblotting in cultured vascular smooth muscle cells. and in rat carotid arteries in vivo after balloon injury. Adenovirus-mediated overexpression and siRNA-mediated knockdown of KLF4 were used to examine the role of KLF4 in mediating the ...
ObjectiveIn balloon-injured rat carotid arteries, angiotensin-converting enzyme inhibitors (ACEI) decrease neointima formation, and a kinin receptor antagonist partially reverses this inhibitory effect. We studied which of the events leading to neointima formation are involved in the effects of ACEI
The present study demonstrates that arginase plays a fundamental role in vascular growth after injury. Arterial injury stimulates arginase activity and arginase I protein expression in the vessel wall, and local arginase inhibition leads to a significant decline in VSMC DNA synthesis and reduced intimal thickening. In addition, this study shows that arginase promotes the entry of VSMCs into the cell cycle. Arginase inhibition or arginase I knockdown arrests VSMCs in G0/G1, and this is associated with the induction of the cyclin-dependent protein kinase inhibitor, p21. These findings illustrate a critical role for arginase in cell cycle progression and identify arginase I as a novel therapeutic target for the treatment of occlusive vascular disorders.. In the present study, we are the first to demonstrate that arginase plays an integral role in the remodeling response after arterial injury. Balloon injury of rat carotid arteries resulted in a sustained increase in arginase activity in the vessel ...
PAN Czytelnia Czasopism, Safety of the long-term application of QuikClot Combat Gauze, ChitoGauze PRO and Celox Gauze in a femoral artery injury model in swine - a preliminary study - Polish Journal of Veterinary Sciences
REFEREED JOURNAL ARTICLES. Yang, X, Thomas, DP, Zhang,X, Culver, BW, Alexander, BM, Murdoch, WJ, Rao, MN, Tulis, DA, Ren, J, Sreejayan, N. (2006) Curcumin Inhibits Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol. 26: 85-90.. Dong F, Zhang X, Li S-Y, Zhang Z, Ren Q, Culver B, Ren J. 2005. Involvement of NADPH oxidase and JNK in homocysteine-induced oxidative stress and apoptosis in human umbilical vein endothelial cells. Cardiovasc. Toxicol. 5:9-20.. Li S-Y, Golden KL., Jiang Y, Graham C, Wang G-J, Privratsky JR, Zhang X, Eason AR, Culver B, Ren J. 2005. Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocyte from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. Cell Biochem Biophys. 42: 1-12.. Li S-Y, Culver B, Ren J. 2003. Benefit and risk of exercise on myocardial function in diabetes. ...
BACKGROUND: Population-based studies have shown that exercise reduces cardiovascular morbidity and mortality. However, it is unknown whether these effects are solely a result of risk factor modification or whether exercise directly affects the homeostasis of the vessel wall. METHODS AND RESULTS: We subjected 19-week-old apolipoprotein E (apoE)-knockout mice (apoE(-/-); n=25) to a 6-week training program on a motorized treadmill. The control group consisted of 17 sedentary mice. After 3 weeks in the program, training and sedentary mice underwent carotid artery injury with ferric chloride. Training was then resumed for another 3 weeks. Exercise did not change body weight or lipid levels in apoE(-/-) mice but resulted in upregulated expression of nitric oxide synthase in the endothelium. Physical training did not significantly affect the thrombotic response to injury. However, morphometric analysis of vessels harvested 3 weeks after injury showed that neointima formation was reduced in the ...
Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice. - Huan Wang, Weiyu Zhang, Rong Tang, Robert P Hebbel, M Anna Kowalska, Chunxiang Zhang, Jamey D Marth, Minoru Fukuda, Chuhong Zhu, Yuqing Huo
Vascular injuries in lower limbs are rare but serious events. If not detected and managed correctly and timely they can lead to permanent functional impairment and even limb loss. The increasing number of orthopaedic interventions, worldwide, makes awareness of this problem among orthopaedic surgeons important.. The overall aim of this thesis was to describe lower limb orthopaedic injuries with associated concomitant arterial injuries, especially to the popliteal artery. Epidemiology, mechanisms of injury, management, outcomes and the patient perspective were all addressed. The research questions were generated from clinical praxis. Vascular injuries are rare events, but by using as the National Patient (NPR) and National Vascular registries (Swedvasc) a relatively speaking large cohort was studied. Deep interviews with qualitative study method were used to investigate the patients perspective.. In papers I and II iatrogenic popliteal artery injuries (PAI) in knee-replacements, and in ...
PhD Project - Exploring the similarities between neointimal formation after vascular injury and tumour growth at University of Bristol, listed on FindAPhD.com
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Arteriosclerosis Disease risk arising from the concentration of lipids on the inner membrane of the arteries, causing Bansdadha partially or completely. This may cause the disease to disability and death, as it may lead to diseases vary according to the affected area, leading injured arteries of the brain to the nervous system and brain, while the injured arteries of the parties, could cause a deficiency in the blood supply to the muscles of the legs, and the injury of the coronary arteries leading to angina a heart attack. And the factors that lead to the disease many of them: A high proportion of fat in the food. 2 smoking. 3 high blood pressure. 4 alcohol consumption. 5 lack of movement. 6 stress and tension. 7 diabetes. 8 menopause and the accompanying hormonal secretions. 9 obesity. 10 years old. Genetics 11. 12 Gender. 13 categories of blood. One way to prevent this disease that follows the one the following tips: A reduction of weight and avoid foods that help the accumulation of grease ...
Stwierdzenie nadużywania internetu i nowych technologii przez młodzież prowadzi zazwyczaj do postawienia dość ogólnikowej diagnozy „uzależnienia
Hello, I m 39 years old. I have been on trt from 7 months. 200mg/wk. 1 week ago started encounter ED problems. I was not be able to use AI for around
Hello, I m 39 years old. I have been on trt from 7 months. 200mg/wk. 1 week ago started encounter ED problems. I was not be able to use AI for around
Bilirubin is a heme metabolite generated by the concerted action of the enzymes heme oxygenase and biliverdin reductase. Although long considered a toxic byproduct of heme catabolism, recent preclinical, and clinical studies indicate the bilirubin exerts beneficial effects in the circulation. In the present study, we determined whether local administration of bilirubin attenuates neointima formation following injury of rat carotid arteries. In addition, the ability of bilirubin to regulate the proliferation and migration of human arterial smooth muscle cells (SMCs) was investigated. Local perivascular administration of bilirubin immediately following balloon injury of rat carotid arteries significantly attenuated neointima formation. Bilirubin-mediated inhibition of neointimal thickening was associated with a significant decrease in ERK activity and cyclin D1 and A protein expression, and an increase in p21 and p53 protein expression in injured blood vessels. Treatment of human aortic SMCs with ...
TY - JOUR. T1 - Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs. AU - Eto, Yasuhiro. AU - Shimokawa, Hiroaki. AU - Hiroki, Junko. AU - Morishige, Kunio. AU - Kandabashi, Tadashi. AU - Matsumoto, Yasuharu. AU - Amano, Mutsuki. AU - Hoshijima, Masahiko. AU - Kaibuchi, Kozo. AU - Takeshita, Akira. PY - 2000/6. Y1 - 2000/6. N2 - Restenosis after angioplasty still remains a major problem for which neointimal formation appears to play an important role. Recent studies in vitro suggested that Rho kinase, a target protein of Rho, is important in various cellular functions. We thus examined whether Rho kinase is involved in the restenotic changes after balloon injury. In vivo gene transfer was performed immediately after balloon injury in both sides of the porcine femoral arteries with adenoviral vector encoding either a dominant negative form of Rho kinase (AdDNRhoK) or β-galactosidase (AdLacZ) as a control. One week after the transfer, ...
Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. No sex-based differences were observed. Mechanistic studies suggested that Fn-EDA mediates integrin- and TLR4-dependent proliferation and migration through activation of FAK/Src and Akt1/mTOR signaling, respectively. Specific deletion of Fn-EDA in SMCs, but not in endothelial cells, reduced intimal hyperplasia and suppressed the SMC synthetic phenotype concomitant with ...
Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. No sex-based differences were observed. Mechanistic studies suggested that Fn-EDA mediates integrin- and TLR4-dependent proliferation and migration through activation of FAK/Src and Akt1/mTOR signaling, respectively. Specific deletion of Fn-EDA in SMCs, but not in endothelial cells, reduced intimal hyperplasia and suppressed the SMC synthetic phenotype concomitant with ...
Ateroskleroz hayvan modelleri mekanizmasını anlamak ve plak geliştirme veya yırtılması, ölüm önde gelen nedenidir sanayileşmiş dünya...
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Background Traumatic paediatric arterial injuries are a great challenge due to low incidence and specific characteristics of paediatric anatomy and physiology. The aim of the present study was to...
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CMV is thought to be a key pathogen involved in the pathogenesis of TV in human allografts. To evaluate the direct effect of CMV infection on vascular biology, we used a rat model in which aortic allografts were infected ex vivo with RCMV prior to transplantation. We chose 2 time points after transplantation to investigate the development of TV, 2 weeks that represented the early phase of TV in rats; and 8 weeks, when TV was fully developed. We found that RCMV influenced vascular remodeling by increased apoptosis of SM-α-actin positive cells in the media layer, decreased extracellular matrix deposits and increased intimal hyperplasia. Moreover, RCMV induced a strong infiltration of CD68-positive macrophages mainly in the adventitia and resulted in an increase of MCP-1 in the allograft, which resulted in migration of adventitial cells towards the intima that most likely also contributed to intimal hyperplasia.. Vessel stability is sustained by a balance between cellular proliferation and ...
The goal of this project is to define the role of peroxisome proliferator-activated receptor (PPAR)3 activation in neointima formation. Neointima formation occu...
Xingsen Xu, Peijian Wang, Zhigang Zhao, Tingbing Cao, Hongbo He, Zhidan Luo, Jian Zhong, Feng Gao, Zhenyu Zhu, Li Li, Zhencheng Yan, Jing Chen, Yinxing Ni, Daoyan Liu and Zhiming Zhu ...
Fingerprint Dive into the research topics of A dynamic notch injury response activates epicardium and contributes to fibrosis repair.. Together they form a unique fingerprint. ...
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Does anyone know what this is? I m obviously going to take Norman into the vet but I was wondering if anyone has seen something similar? I feel like it came out of no where two weeks ago. At first I a
Store norske leksikon er et gratis og komplett oppslagsverk skrevet av fagfolk på bokmål og nynorsk. Med to millioner brukere i måneden og 300 000 leste artikler hver dag er leksikonet Norges største nettsted for forskningsformidling. Leksikonet er eid av de norske universitetene og flere ideelle stiftelser/organisasjoner: ...
His injuries include: Amputation of both arms and both legs; Severed left carotid artery; Broken nose, left eye socket and ... As a result of the EFP entering the vehicle through his door, he sustained severe, permanent and life changing injuries. ... resulting in one fatality and two injuries. ...
... resistant to the vascular damage caused by balloon catheter-induced injury of the external carotid artery; e) less likely to ... SNP variant rs768963 in TBX2R was associated with increased frequency of large artery atherosclerosis, small artery occlusion, ... studies on rat and human cerebral artery preparations indicate that increased blood flow through these arteries triggers ... Toth P, Rozsa B, Springo Z, Doczi T, Koller A (2011). "Isolated human and rat cerebral arteries constrict to increases in flow ...
Margaret Prial, who performed Vetrano's autopsy, described her injuries, including a compressed carotid artery in her neck. The ... She ran alone, despite the expressed concerns of her father, her usual running partner, who was suffering from a back injury. ... and that he had also suffered a hand injury. Lewis's family continued to deny his involvement in the homicide. His father ...
Acute injury to the internal carotid artery (carotid dissection, occlusion, pseudoaneurysm formation) may be asymptomatic or ... Involvement of the petrous segment of the carotid canal is associated with a relatively high incidence of carotid injury. ... They are almost exclusively observed when the carotid canal is fractured, although only a minority of carotid canal fractures ... Pediatric Head Trauma at eMedicine Skull Fracture at eMedicine "About Brain Injury". Brain Injury Association of America. ...
... and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting". ... The first symptom is usually severe headache, and a headache in the setting of recent carotid endarterectomy or carotid ... usually following treatment of carotid artery stenosis. Risk factors include hypertension, particularly high blood pressures in ... Kirchoff-Torres, KF; Bakradze, E (19 March 2018). "Cerebral Hyperperfusion Syndrome After Carotid Revascularization and Acute ...
Other rare complications of mandibular trauma include internal carotid artery injury, and obliteration of the ear canal due to ... Finally, vascular injury can result (with particular attention to the internal carotid and jugular) from high velocity injuries ... The same injury can be seen on the opposite side 3D CT reconstruction of mandible fracture, white arrow marks fracture, red ... In high velocity injuries, the soft tissue can be severely damaged far from the bullet wound itself due to hydrostatic shock. ...
Taylor was hospitalized for a serious ATV accident in which he suffered a severe brain injury and trauma to the carotid artery ...
... and carotid artery injury. There are some suggestions that the Vikings practiced hanging as human sacrifices to Odin, to honour ... A hanging may induce one or more of the following medical conditions, some leading to death: Closure of carotid arteries ... Where death has occurred through carotid artery obstruction or cervical fracture, the face will typically be pale in colour and ... Compromise of the cerebral blood flow may occur by obstruction of the carotid arteries, even though their obstruction requires ...
... carotid artery thrombosis MeSH C10.228.140.300.200.345 - carotid artery injuries MeSH C10.228.140.300.200.345.300 - carotid ... carotid artery injuries MeSH C10.900.250.300.300 - carotid artery, internal, dissection MeSH C10.900.250.300.400 - carotid- ... carotid artery injuries MeSH C10.228.140.300.350.500.300 - carotid artery, internal, dissection MeSH C10.228.140.300.350.500. ... carotid artery, internal, dissection MeSH C10.228.140.300.200.360 - carotid stenosis MeSH C10.228.140.300.200.490 - carotid- ...
... and carotid artery injury. Ron M. Brown writes that hanging has a "fairly imperspicuous and complicated symbolic history". ... About 11 lb (5 kg) of pressure is required to compress the carotid artery; 4.4 lb (2 kg) for the jugular veins; and at least 15 ... compression of the carotid arteries, the jugular veins, or the airway. ... Cervical spine fractures are rare unless the hanging is a drop hanging, which usually causes an injury known as hangman's ...
... or whiplash injury.[7] 1-2% of those with major trauma may have an injury to the carotid or vertebral arteries.[2] In many ... The other type, carotid artery dissection, involves the carotid arteries. Vertebral artery dissection is further classified as ... Vertebral artery dissection is less common than carotid artery dissection (dissection of the large arteries in the front of the ... or for symptoms of carotid artery dissection to occur at the same time as those of vertebral artery dissection.[2] Some give a ...
The probable mechanism of injury for most internal carotid injuries is rapid deceleration, with resultant hyperextension and ... The incidence of spontaneous carotid artery dissection is low, and incidence rates for internal carotid artery dissection have ... Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing blood to the head and brain ... which stretches the internal carotid artery over the upper cervical vertebrae, producing an intimal tear. After such an injury ...
Her wounds, described as superficial, came within two millimeters of her carotid artery. Routier was treated at a hospital and ... They also stated that, despite her injuries, Routier's blood was not found in the garage or anywhere outside the home. The ... medical examiner Vincent DiMaio testified that the wound to Routier's neck came within two millimeters of her carotid artery ... During the trial, the prosecution argued that Routier's injuries were self-inflicted, that the crime scene had been staged, and ...
... and carotid artery injury.[5] Ron M. Brown writes that hanging has a "fairly imperspicuous and complicated symbolic history".[6 ... compression of the carotid arteries, the jugular veins, or the airway.[16][17] About 11 lb (5 kg) of pressure is required to ... compress the carotid artery; 4.4 lb (2 kg) for the jugular veins;[16] and at least 15 kg (33 lb) for the airway.[18] The amount ... Hanna, S.J (2004). "A study of 13 cases of near-hanging presenting to an Accident and Emergency Department". Injury. 35 (3): ...
This artery branches from the superior thyroid artery near its bifurcation from the external carotid artery. Together with the ... making it at risk for injury during surgery. Inferior thyroid artery Diagram showing the origins of the main branches of the ... The superior thyroid artery arises from the external carotid artery just below the level of the greater cornu of the hyoid bone ... carotid arteries. The internal carotid and vertebral arteries. Right side. (Superior thyroid visible at center.) The thyroid ...
... to help Florida win 4-2 in the game after Richard Zedník suffered a neck injury in which he had his external carotid artery cut ... I just tried to get it to the net and it went in every time." Despite missing ten games to injury, Horton was tied with ... Horton has not played in an NHL game since April 2014 due to a back injury. Though he did not officially retire, the surgery ... However, Horton was unavailable for the game due to an injury. The goal scored by Horton in the original fixture was the only ...
Contralateral laryngeal nerve injury. Tracheostoma. Carotid artery stenting is an alternative to carotid endarterectomy in ... Carotid endarterectomy is used to reduce the risk of strokes caused by carotid artery stenosis over time. Carotid stenosis can ... is a surgical procedure used to reduce the risk of stroke from carotid artery stenosis (narrowing the internal carotid artery ... The lumen of the internal carotid artery is opened, and the atheromatous plaque substance removed. The artery is closed using ...
... may develop as a result of arterial dissection in the carotid artery or aorta or as a result of iatrogenic arterial injury (e.g ... Reduction of body temperature also reduces the inflammation response and reperfusion injury. For frostbite injuries, limiting ... Surgical revascularization may be used in the setting of trauma (e.g., laceration of the artery). Amputation is reserved for ... Kostandy, Botros B. (2012). "The role of glutamate in neuronal ischemic injury: the role of spark in fire". Neurol Sci. 33 (2 ...
In 1943 Drunina was seriously injured when a shell fragment struck her in the neck several millimeters from her carotid artery ... Unaware of the severity of her injury, she simply wrapped her neck in bandages and continued to work. Eventually, she was ...
... arterial injury or retroperitoneal bleeding. The investigation chosen will depend on the clinical question and the imaging ... The carotid artery divides into the internal carotid artery and the external carotid artery. The internal carotid artery ... At the throat it forks into the internal carotid artery and the external carotid artery. The internal carotid artery supplies ... Carotid arteries Section of carotid artery with plaque. Blood flows from the common carotid artery(bottom), and divides into ...
Very serious injury can also occur if the jumper's neck or body gets entangled in the cord. More recently, carotid artery ... Traumatic carotid artery dissection caused by bungee jumping. J Vascular Surg 2007;46:1044-6 "Bungee jumping suppresses innate ... Whiplash injuries may occur as the jumper is jolted on the bungee cord and in at least one case, this has led to quadriplegia ... All of these injuries have occurred in fit and healthy people in their twenties and thirties. Bungee jumping has also been ...
... narrowly missing his carotid artery. A portion of his silk neckerchief was carried into the wound by the bullet, preventing a ... to protect personnel from death or serious injuries. There are various mandatory tests which items must pass before they can be ... more serious injury, but the scarf was undamaged. The Tombstone Epitaph reported, "A silken armor may be the next invention." ...
... carotid artery diseases MeSH C14.907.253.123.331 - carotid artery thrombosis MeSH C14.907.253.123.345 - carotid artery injuries ... carotid artery injuries MeSH C14.907.253.535.500.300 - carotid artery, internal, dissection MeSH C14.907.253.535.500.350 - ... carotid artery, internal, dissection MeSH C14.907.253.123.360 - carotid stenosis MeSH C14.907.253.123.490 - carotid-cavernous ... carotid artery, internal, dissection MeSH C14.907.253.123.345.400 - carotid-cavernous sinus fistula MeSH C14.907.253.123.353 - ...
... blockage in the carotid artery: some researchers think that a blockage of the carotid artery leads to the under-/no development ... Hydranencephaly is a result of an injury of the nervous system or an abnormal development of the nervous system. The neural ... The carotid artery is the most important blood supplier of the brain. With a blockage, the brain barely receives blood. Blood ... The cause of these injuries/development is not clear. Theories regarding the causes of hydrancephaly include: ...
... and the injury that had caused her death had been the severence of her right carotid artery. This conclusion was supported by a ...
... known for surviving a life-threatening injury during a 1989 NHL game when Steve Tuttle's skate blade sliced his carotid artery ... As they collided, Tuttle's skate blade hit the right front side of Malarchuk's neck, severing his carotid artery and partially ... Bisson, Leslie J.; Sanders, Samuel M.; Noor, Sonya; Curl, Richard; McCormack, Robert (2009). "Common Carotid Artery Laceration ... lacerating his common carotid artery, causing immediate massive blood loss. Although Malarchuk initially refused to view the ...
He suffered a basilar skull fracture, damaged his carotid artery and sinus. He recovered and returned to race the entire 2000 ... Carelli raced every series race until he suffered near-fatal injuries when his truck hit the wall during a race at Memphis ...
The attacker severed Micah's left jugular vein, while narrowly missing his carotid artery by one millimetre (0.039 in). ... specifically a knife injury to his throat. ...
Landau's carotid artery was severed by a bullet passing through his neck, and Rosenkrantz was hit repeatedly at point-blank ... Nevertheless, despite their injuries, both gangsters rose to their feet, returned fire, and drove the assassins out of the ... He eventually died from his injuries 29 hours after the shooting. Schultz was baptized and received the last rites from a ...
The attacker stabbed the soldier several times, narrowly missing Cordier's jugular vein and carotid artery. The soldier ... He was stabbed in the neck and had lost a considerable amount of blood; however, his injuries were not life-threatening. He was ...
Chung CL, Côté P, Stern P, L'espérance G (2014). "The Association Between Cervical Spine Manipulation and Carotid Artery ... Ndetan HT, Rupert RL, Bae S, Singh KP (February 2009). "Prevalence of musculoskeletal injuries sustained by students while ... The incidence of internal carotid artery dissection following cervical spine manipulation is unknown.[151] The literature ... There is very low evidence supporting a small association between internal carotid artery dissection and chiropractic neck ...
... a different arrangement of the carotid arteries, a gall bladder, differences in the skull bones, and lack the Dyck texture ... causing serious injury.[84] For this reason, parrot rescue groups estimate that most parrots are surrendered and rehomed ...
... of the carotid arteries. These arteries are the large blood vessels in your neck that feed your brain. Transcranial Doppler ( ... reperfusion injury - hemorrhagic transformation - cold exposure - rupture of an aneurysm or arteriovenous malformation (AVM) - ... Carotid duplex: A carotid duplex is an ultrasound study that assesses whether or not you have atherosclerosis (narrowing) ...
Surrounding structures such as the pleura and carotid artery are also at risk of damage with the potential for pneumothorax or ... One reason veins are preferred over arteries for intravascular administration is because the flow will pass through the lungs ... even cannulation of the artery. There are several types of central IV access, depending on the route that the catheter takes ...
Beberapa ahli lain mempertimbangan klasifikasi berdasarkan fenotipe seperti keberadaan internal carotid artery plaque, intima- ... "Neural plasticity after peripheral nerve injury and regeneration". Group of Neuroplasticity and Regeneration, Institute of ... baik yang bersifat intrakranial seperti moderate middle cerebral artery stenosis, ekstrakranial seperti vertebral artery origin ... Sistem TOAST membagi stroke menjadi 5 subtipe yaitu,[11][12] large artery atherosclerosis (LAAS), cardiaoembolic infarct (CEI ...
... a network of arteries originating from the ophthalmic artery. The ophthalmic rete is analogous to the carotid rete found in ... When threatened, common ostriches run away, but they can cause serious injury and death with kicks from their powerful legs.[33 ... The interatrial artery of the ostrich is small in size and exclusively supplies blood to only part of the left auricle and ... The coronary arteries start in the right and left aortic sinus and provide blood to the heart muscle in a similar fashion to ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Endothelial injury and dysfunction. *Fibrinoid necrosis of the arterioles. *Deposition of platelets and fibrin ... leading to pathologic changes in the small arteries of the kidney. Affected arteries develop endothelial dysfunction and ... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ...
Fluid can be injected into the arterial system (typically through the carotid or femoral arteries), the main body cavities, ... King AI, Viano DC, Mizeres N, States JD (April 1995). "Humanitarian benefits of cadaver research on injury prevention". The ... Erasistratus also discovered and distinguished between many details within the veins and arteries of the human body. Herophilus ... it was approximated that improvements made to cars since cadaver testing have prevented 143,000 injuries and 4250 deaths. ...
The ascending cervical artery is a small branch which arises from the inferior thyroid artery as it passes behind the carotid ... This makes it vulnerable to injury during surgery that involves ligating the inferior thyroid artery, such as excision of the ... ACA (anterior communicating, Recurrent artery of Heubner, Orbitofrontal artery). *MCA (anterolateral central, Prefrontal artery ... The inferior thyroid artery is an artery in the neck. It arises from the thyrocervical trunk and passes upward, in front of the ...
There is no costocervical artery. There is no direct connection between the internal carotid artery and the vessels of the ... If the orca pod is large, its members may sometimes be able to kill adult female sperm whales and can at least injury an entire ... Experimental studies attempting to duplicate this effect have been unable to replicate the supposed injuries, casting doubt on ... The arteries that leave the aortic arch are positioned symmetrically. ...
In humans, hypoxia is detected by the peripheral chemoreceptors in the carotid body and aortic body, with the carotid body ... to an extent that parallels the degree to which resting mean pulmonary artery pressure is elevated. Although the severity of ... Electrical injury. *Drowning. *Lightning injuries. Ungrouped skin conditions resulting from physical factors. *Dermatosis ...
Spinal cord injury. *Anterior spinal artery syndrome. *Brown-Séquard syndrome. *Cauda equina syndrome ... Chapter 5, "Pathology of Brain Damage After Head Injury" Cooper P and Golfinos G. 2000. Head Injury, 4th Ed. Morgan Hill, New ... The risk of death from an intraparenchymal bleed in traumatic brain injury is especially high when the injury occurs in the ... "Overview of Adult Traumatic Brain Injuries." Archived 2008-02-27 at the Wayback Machine Retrieved on 2008-01-16. ...
To its sides run the carotid arteries and inferior thyroid arteries; and to its sides on its back surface run the recurrent ... Scarring from tracheobronchial injury or intubation; or inflammation associated with granulomatosis with polyangiitis may also ... To the front left lie the large blood vessels the aortic arch and its branches the left common carotid artery and the ... These arteries join (anastamoses) with ascending branches of the bronchial arteries, which are direct branches from the aorta, ...
H05.81) Carotid cavernous fistula. *(H70.1) Mastoid fistula *Craniosinus fistula: between the intracranial space and a ... So many cases have been reported that the destruction of the vagina is considered a war injury and recorded by doctors as a ... Pulmonary arteriovenous fistula: between an artery and vein of the lungs, resulting in shunting of blood. This results in ... Fistulas are usually caused by injury or surgery, but they can also result from an infection or inflammation.[4] Fistulas are ...
The posterior auricular artery is a direct branch of the external carotid artery, and the anterior auricular arteries are ... Injury. Outer ear. Injuries to the external ear occur fairly frequently, and can leave minor to major deformity. Injuries ... ascending pharyngeal artery, internal carotid artery, and the artery of the pterygoid canal.[8] ... "Ear Injuries" (PDF). Council of Europe.. *^ "Ear Injury - Injuries and Poisoning". Merck Manuals Consumer Version. Retrieved ...
... left common carotid artery, and left subclavian artery, as well as geometrically similar, nonplanar curvature in the aortic ... Mackenzie, SJ (2015). "Innervation and function of rat tail muscles for modeling cauda equina injury and repair". Muscle and ... Milcheski, Dimas (2012). "Development of an experimental model of degloving injury in rats". Brazilian Journal of Plastic ... as the high density of vascular tissue within the tail becomes exposed upon avulsion or similar injury to the structure. The ...
This artery branches from the superior thyroid artery near its bifurcation from the external carotid artery. Together with the ... making it at risk for injury during surgery. ... The superior thyroid artery arises from the external carotid ... The sternocleidomastoid branch runs downward and laterally across the sheath of the common carotid artery, and supplies the ... The infrahyoid branch (or hyoid artery): a small artery that runs along the lower border of the hyoid bone beneath the ...
The cavernous sinus also contains the carotid artery, which supplies blood to the brain; occasionally, compression of the ... traumatic brain injury, pregnancy (during which the pituitary enlarges) and treatment with estrogens. Hormonal stimulation ... especially coronary artery bypass graft, where there are significant fluctuations in the blood pressure), disturbances in blood ... but tumors develop a blood supply from the nearby inferior hypophyseal artery that generates a higher blood pressure, possibly ...
Atherosclerosis can lead to coronary artery disease, carotid artery disease, peripheral artery disease, and aneurysms. Standing ... of all worker injury and illness". Considerable research has been conducted as to the extent of muscle injuries and all have ... The authors also found that men with carotid stenosis or ischemic heart disease were at greater risk for the progression of ... 2000) the authors examined the relationship between standing at work and the progression of carotid atherosclerosis in men. ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Trauma[6] and minor leg injury[12]. *Previous VTE[13]. *Oral contraceptives[8][14] ... Bauersachs RM, Lindhoff-Last E, Ehrly AM: [Ambulatory treatment of an acute pulmonary artery embolism in fresh thigh vein ...
The ophthalmic artery is a crucial structure in the orbit, as it is often the only source of collateral blood to the brain in ... Injury to any one of these structures by infection, trauma or neoplasm can cause temporary or permanent visual dysfunction, and ... cases of large internal carotid infarcts, as it is a collateral pathway to the circle of Willis. In addition, there is the ... The optic canal contains the optic nerve (cranial nerve II) and the ophthalmic artery, and sits at the junction of the sphenoid ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... "WHO Disease and injury country estimates". World Health Organization. 2009. Retrieved Nov 11, 2009.. ...
Specifically, it looks for calcium deposits in the coronary arteries that can narrow arteries and increase the risk of heart ... or traumatic brain injury are suspected.[23] Even in emergency situations, when a head injury is minor as determined by a ... allowing radiologists to assess the extent of occlusion in the coronary arteries, usually in order to diagnose coronary artery ... This ranges from arteries serving the brain to those bringing blood to the lungs, kidneys, arms and legs. An example of this ...
This separates the carotid artery from the vertebral artery and the carotid artery can be massaged against this tubercle to ... Injuries to the cervical spine are common at the level of the second cervical vertebrae, but neurological injury is uncommon. ... The carotid tubercle is also used as a landmark for anaesthesia of the brachial plexus and cervical plexus. ... Common patterns of injury include the odontoid fracture and the hangman's fracture, both of which are often treated with ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Chest spiral CT scan with radiocontrast agent showing multiple filling defects of principal branches of the pulmonary arteries ...
Stenosis of the carotid arteries can presage cerebral infarcts (strokes). DVT in the legs can be found via ultrasound before it ... Extensive hemoperitoneum (bleeding inside the body cavity) or injury to the major organs may require emergent surgical ... Interventional radiologists diagnose and treat several disorders including peripheral vascular disease, renal artery stenosis, ... clots in the arteries of the lungs), aortic dissection (tearing of the aortic wall), appendicitis, diverticulitis, and ...
Endothelial injury is almost invariably involved in the formation of thrombi in arteries, as high rates of blood flow normally ... The former affects vessels such as the internal carotids, vertebral and the circle of Willis. The latter can affect smaller ... Targeting ischemia/reperfusion injury[edit]. Main article: Reperfusion injury. With reperfusion comes ischemia/reperfusion (IR ... Endothelial cell injury[edit]. Any inflammatory process, such as trauma, surgery or infection, can cause damage to the ...
... which arises from the ophthalmic artery, internal carotid artery, anterior cerebral artery, and anterior communicating arteries ... The optic nerve can be damaged when exposed to direct or indirect injury. Direct optic nerve injuries are caused by trauma to ... The most common site of injury of the optic nerve is the intracanalicular portion of the nerve. Deceleration injuries from ... can cause injury to the optic nerve, but this is readily manageable if it does not involve direct optic nerve injury and is ...
Thrombosis of Internal Carotid Artery after Soft-palate Injury Br Med J 1957; 2 :750 ... Thrombosis of Internal Carotid Artery after Soft-palate Injury. Br Med J 1957; 2 doi: https://doi.org/10.1136/bmj.2.5047.750 ( ...
The bullet entered through the left anterior neck and severed the left common carotid artery. Emergency surgery was performed ... Carotid Artery Injuries*. Carotid Artery, Common / surgery. Cerebral Infarction / etiology, surgery. Dystonia / etiology*, ... The bullet entered through the left anterior neck and severed the left common carotid artery. Emergency surgery was performed ...
Carotid injury was performed in WT and IL-10 KO mice by wire injury method. (A-B) Mice were injected with Evans blue (0.5%) 2- ... Carotid injury was performed in WT and IL-10 KO mice by wire injury method for 28 days. (A-B) 24h prior to euthanasia, BrdU (30 ... C-D) For morphometric analysis, 28 days after injury carotid artery were isolated and neo-intimal hyperplasia was measured by ... C) ET and H&E staining of carotid artery sections on 28 days post-injury visualized neo-intimal thickening. Representative ...
THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS ... "Carotid Artery Injuries" by people in Harvard Catalyst Profiles by year, and whether "Carotid Artery Injuries" was a major or ... "Carotid Artery Injuries" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Carotid Artery Injuries*Carotid Artery Injuries. *Artery Injuries, Carotid. *Artery Injury, Carotid ...
THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS ... Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; ... and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473) ... Carotid; Injuries, Carotid Artery; Artery Injuries, Carotid; Artery Injury, Carotid; Artery Trauma, Carotid; Carotid ...
Home , May 1967 - Volume 7 - Issue 3 , CAROTID ARTERY OCCLUSION DUE TO NONPENETRATING INJURY ... THE SPECTRUM OF BLUNT INJURY TO THE CAROTID ARTERY: A MULTICENTER PERSPECTIVE ... Blunt Cerebrovascular Injuries: Does Treatment Always Matter? * Blunt cerebrovascular injuries: Redefining screening criteria ... Blunt cerebrovascular injury screening with 64-channel multidetector computed tomography: More slices finally cut it ...
Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury. Hiroyuki Morita ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ...
Penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures ... Carotid artery injuries caused by blunt traumaAnn SurgYear: 198019274777406566. 3. Roon AJ,Christensen N. Evaluation and ... Zone II is the most common site of carotid artery injury, where there is often a tendency for the hematoma to be compressed and ... Penetrating Carotid Artery Injuries Treated by an Urgent Endovascular Stent Technique: Report of Two Cases ...
... bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in ... RESULTS: Cerebral ACT and BHB levels increased significantly in Group T after 30min of carotid occlusion (time 0). The highest ... CONCLUSIONS: The partial transient acute global brain ischemia induced by the bilateral carotid occlusion in Wistar rats ... ischemia/reperfusion through an experimental model of brain ischemia induced by simple occlusion of common carotid arteries ( ...
A 22-year-old man sustained a strangulation-type injury to the neck, with bilateral blunt carotid artery injuries detected on ... Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging ... We report a case of bilateral internal carotid artery (ICA) injury due to strangulation. At presentation there was no ... 2. Kerby J, May A, Gomez C, Rue L. Treatment of bilateral blunt carotid injury using percutaneous angioplasty and stenting: ...
Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery ...
A segment of the common carotid artery 1 cm long was isolated by temporary ligation of the proximal common carotid artery and ... and Erk proteins in injured carotid artery. A, 2 and 5 days after injury; B, 2 weeks after injury. ... Enhanced Recovery of Injury-Caused Downregulation of Paxillin Protein by eNOS Gene Expression in Rat Carotid Artery. Mechanism ... Activation of MAP kinase in vivo follows balloon overstretch injury of porcine coronary and carotid arteries. Circ Res. 1997;81 ...
... was introduced through the left external carotid artery and passed into the common carotid artery. Injury was induced by ... The external carotid artery was ligated, and the wound was closed. Uninjured right carotid arteries were used as controls. At ... Effect of Injury on GAPDH mRNA Expression. Northern analysis of RNA from uninjured and injured rat carotid arteries was used to ... Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury. Karen E. ...
... a pig carotid artery model in which both deep medial tears and stretch-induced injury occur was used. Both types of injury are ... In the rat carotid artery, injury increases tissue levels of gelatinase B and activates gelatinase A,13 19 further implicating ... Response to Balloon Injury in the Pig Carotid Artery. As described previously,23 balloon inflation caused dilatation in all ... Sections of a carotid artery harvested 7 days after balloon injury were hybridized with 106 cpm of gelatinase B antisense RNA ( ...
Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis assessed as ...
Inflammation plays an essential role for destabilization and rupture of carotid atherosclerotic plaques causing embolic ... Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. Four to nine days (average six) post injury ... This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by ... Determination of acute vascular injury and edema in porcine carotid arteries by T2 weighted cardiovascular magnetic resonance. ...
The purpose of this study attempted to analyze the potential risk factors for internal carotid artery injury during simple ... Anatomic variations of carotid arteries were classified, and various distances from the internal carotid arteries to the ... Risk factors for internal carotid artery injury in adults during simple nasopharyngeal surgeries. Zeitschrift:. European ... The purpose of this study attempted to analyze the potential risk factors for internal carotid artery injury during simple ...
Radiation injury involving the internal carotid artery. Report of two cases - Journal of Neurosurgical Sciences 2000 September; ... Radiation injury involving the internal carotid artery. Report of two cases. Santoro A., Bristot R., Paolini S., Di Stefano D ... Radiation ther-a-py is an uncom-mon -cause of sten-o-sis and occlu-sions of the cer-vi-cal inter-nal carot-id -artery (ICA). We ... Cerebral angio-gra-phy -obtained on admis-sion -showed occlu-sion of the -right ICA and -right sub-cla-vian arter-ies, -both - ...
Objective: Internal carotid artery injury (ICAI) is a rare, life-threatening complication of endoscopic endonasal approaches ... Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal ... Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal ... Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal ...
CONCLUSIONS Patients who have carotid stents placed for blunt carotid pseudoaneurysms have a 21% complication rate and a ... underwent carotid stent placement. There were 4 complications in patients undergoing carotid stent placement: 3 strokes and 1 ... 8 patients had poststent carotid occlusion despite having received concurrent anticoagulation therapy. Carotid occlusion rates ... HYPOTHESIS Carotid stenting is safe and effective for blunt CAIs. DESIGN Analysis of a prospective database of all patients ...
... Cerebral embolism, ... due to a traumatic aneurysm of the internal carotid artery, and a duodenal tear occurred in a young woman who was wearing a ... ITRD Terms: 2035: Abdomen; 1643: Accident; 2030: Brain; 2163: Injury; 1476: Safety belt; 9084: Use ... The aneurysm was treated by proximal carotid ligation. (Author/TRRL). * Availability: *Find a library where document is ...
Internal carotid artery dissection at the supraclinoid portion after severe traumatic head injury in a child Posted By Junya ... Endovascular repair of traumatic cervical internal carotid artery injuries: a safe and effective treatment option. AJNR Am J ... Anterior cerebral artery, anterior choroidal artery and posterior communication artery are detected. ... www.signavitae.com/2013/10/internal-carotid-artery-dissection-at-the-supraclinoid-portion-after-severe-traumatic-head-injury-in ...
... arterial bleeding was encountered near the right internal carotid artery (ICA). Durable hemostasis could not be achieved with ... Arterial injuries, although serious, are not always catastrophic. Critical steps are immediate recognition of bleeding, ... Given the presence of good collateral flow through the anterior and posterior communicating arteries, the right ICA was ... Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa ...
What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean? ... Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. ... common carotid artery. (redirected from Carotid artery injuries). Also found in: Dictionary, Thesaurus, Encyclopedia. com·mon ... Carotid artery injuries , definition of Carotid artery injuries by Medical dictionary https://medical-dictionary. ...
"Primary Repair vs Ligation for Carotid Artery Injuries",. abstract = "The morbidity and mortality of carotid arterial injuries ... Ledgerwood, A. M., Mullins, R., & Lucas, C. E. (1980). Primary Repair vs Ligation for Carotid Artery Injuries. Archives of ... Ledgerwood, AM, Mullins, R & Lucas, CE 1980, Primary Repair vs Ligation for Carotid Artery Injuries, Archives of Surgery, vol ... Ledgerwood, Anna M. ; Mullins, Richard ; Lucas, Charles E. / Primary Repair vs Ligation for Carotid Artery Injuries. In: ...
Injury of carotid artery of neck. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Applicable To*Injury of carotid ... Unspecified injury of right carotid artery. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code *S15.001 should not be used ... Injury of blood vessels at neck level. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Code Also*any associated open ... Injury, poisoning and certain other consequences of external causes. Note*Use secondary code(s) from Chapter 20, External ...
A carotid artery injury model was performed in 8 wild-type and 8 CRP2-deficient (CRP2-/-) mice; the right carotid artery wall ... 2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent. ... of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury ... SNR and CNR of the injured right compared to the non injured left carotid artery was significantly increased (p , 0.001) both ...
Injury of carotid artery of neck. 2016 2017 2018 Non-Billable/Non-Specific Code Applicable To*Injury of carotid artery (common ... Unspecified injury of right carotid artery, sequela. 2016 2017 2018 Billable/Specific Code POA Exempt *S15.001S is a billable/ ... Injury of blood vessels at neck level. 2016 2017 2018 Non-Billable/Non-Specific Code Code Also*any associated open wound (S11.- ... Injury, poisoning and certain other consequences of external causes. Note*Use secondary code(s) from Chapter 20, External ...
Carotid Artery injury Simulation for participants * 3D Surgical Anatomy and Surgery in 16x9 ft screen ...
title = "Carotid Artery Injury After Endonasal Surgery",. abstract = "Carotid artery injury during endonasal surgery is the ... Carotid artery injury during endonasal surgery is the most feared and catastrophic complication. Internal carotid artery injury ... Carotid Artery Injury After Endonasal Surgery. Together they form a unique fingerprint. * Carotid Artery Injuries Medicine & ... Carotid artery injury during endonasal surgery is the most feared and catastrophic complication. Internal carotid artery injury ...
  • An emergency craniotomy was performed, and traumatic carotid artery (CA) dissection (tCAD) was revealed by cerebral angiography. (signavitae.com)
  • Angiography of the right ICA showed the pearl and string sign at the supraclinoid portion of the ICA, and traumatic carotid artery (CA) dissection (tCAD) was suspected. (signavitae.com)
  • Vascular aspects: aneurysmal dissection of the right internal carotid in its subpetrous portion, additional image on left lateral face of the left internal carotid in its intracavernous portion, strongly suggestive of posttraumatic pseudoaneurysm (contact fracture of carotid canal). (imaios.com)
  • This report describes recently treated patients with carotid artery dissection caused by blunt softball injuries, as well as the results of a study of carotid artery trauma in a community. (elsevier.com)
  • Data obtained through the medical records linkage system used for epidemiologic studies in Olmsted County, MN were used to identify all cases of traumatic internal carotid artery dissection diagnosed from 1987 through 1994. (elsevier.com)
  • In two patients (50%) the carotid dissection was a result of the direct impact of a softball. (elsevier.com)
  • Vascular aspects: dissection of the subpetrous portion of both internal carotids (left aneurysmal dissection). (imaios.com)
  • Styloid process length and styloid/hyoid bone proximity to the internal carotid artery (ICA) have been implicated in certain carotid pathologies (e.g. carotid artery dissection). (bioportfolio.com)
  • Few population based analyses exist for blunt trauma to the carotid artery resulting in dissection. (dcorthoacademy.org)
  • Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related? (jamanetwork.com)
  • Vertebral artery dissection ( VAD ) is a flap-like tear of the inner lining of the vertebral artery , which is located in the neck and supplies blood to the brain . (wikipedia.org)
  • The symptoms of vertebral artery dissection include head and neck pain and intermittent or permanent stroke symptoms such as difficulty speaking , impaired coordination and visual loss . (wikipedia.org)
  • Vertebral dissection may occur after physical trauma to the neck, such as a blunt injury (e.g. traffic collision ), strangulation or chiropractic manipulation , but may also happen spontaneously. (wikipedia.org)
  • Vertebral artery dissection is less common than carotid artery dissection (dissection of the large arteries in the front of the neck). (wikipedia.org)
  • Vertebral artery dissection is one of the two types of dissection of the arteries in the neck. (wikipedia.org)
  • The other type, carotid artery dissection, involves the carotid arteries . (wikipedia.org)
  • Vertebral artery dissection is further classified as being either traumatic (caused by mechanical trauma to the neck) or spontaneous, and it may also be classified by the part of the artery involved: extracranial (the part outside the skull) and intracranial (the part inside the skull). (wikipedia.org)
  • Head pain occurs in 50-75% of all cases of vertebral artery dissection. (wikipedia.org)
  • [2] 8% of all cases of vertebral and carotid dissection are diagnosed on the basis of pain alone. (wikipedia.org)
  • If the dissection of the artery extends to the part of the artery that lies inside the skull, subarachnoid hemorrhage may occur (1% of cases). (wikipedia.org)
  • 13-16% of all people with vertebral or carotid dissection have dissection in another cervical artery. (wikipedia.org)
  • It is therefore possible for the symptoms to occur on both sides, or for symptoms of carotid artery dissection to occur at the same time as those of vertebral artery dissection. (wikipedia.org)
  • The causes of vertebral artery dissection can be grouped under two main categories, spontaneous and traumatic. (wikipedia.org)
  • A vertical neck incision along the anterior border of the SCM muscle dissection through skin, subcutaneous tissue, and platysma, posterolateral retraction of the SCM opening the carotid sheath. (brainscape.com)
  • Dissection, Carotid Artery - Cervical artery dissection is a significant cause of stroke in patients under 40 years of age. (searchbeat.com)
  • The diagnosis and management of penetrating cerebrovascular injury and spontaneous cerebrovascular dissection are reviewed elsewhere. (uptodate.com)
  • See 'Penetrating neck injuries: Initial evaluation and management' and 'Spontaneous cerebral and cervical artery dissection: Clinical features and diagnosis' . (uptodate.com)
  • CAD, which can lead to thrombosis and occlusion of the anterior, middle cerebral artery or CA, is one of the major causes of ischemic stroke in children. (signavitae.com)
  • In particular, mechanical injury from the procedure results in extensive endothelial denudation, exposing the underlying collagen IV-rich basal lamina, which promotes both intravascular thrombosis and smooth muscle proliferation. (pnas.org)
  • Penetrating carotid artery injuries treated by an urgent endovascular stent technique: report of two cases. (biomedsearch.com)
  • Here we report on the endovascular stent techniques used in two cases to address penetrating carotid artery injuries and review the literature. (biomedsearch.com)
  • We successfully treated patients who had externally penetrating injuries in neck zone II and were confirmed to have the concurrent presence of large vessel injuries in neck zones I and III by inserting an endovascular stent in an urgent interventional angiography procedure. (biomedsearch.com)
  • Covered stent exclusion of blunt traumatic carotid artery pseudoaneurysm: case report and review of the literature. (semanticscholar.org)
  • The aim of the study is to confirm, whether the MER® stent can be used, without limitations, for the endovascular carotid stenosis treatment in daily clinical practice. (bioportfolio.com)
  • During biopsy of his oropharyngeal lesion, a specimen of tissue was retrieved, with the carotid stent within. (hindawi.com)
  • There is no case reported whereby an internal carotid artery endovascular stent was removed accidentally during a lateral pharyngeal mass biopsy, and without bleeding. (hindawi.com)
  • Preoperative Computed Tomography scanning (CT) showed the irregular ulcer at the right oropharyngeal space, with the right carotid artery stent completely occluded with no distal perfusion (Figure 1 ), and it was encased in the mass of necrotic tissue. (hindawi.com)
  • On inspection, the carotid endovascular stent was identified, invaded, and surrounded by the mass of necrosis that was filling the lateral oropharyngeal wall (Figure 3 ). (hindawi.com)
  • Contrast Enhanced computed tomography scan of the neck showing the right carotid stent occluded with no blood flow in the lumen. (hindawi.com)
  • Frequency and management of recurrent stenosis after carotid artery stent implantation. (naver.com)
  • Determinants of in-stent restenosis after carotid angioplasty: a case-control study. (naver.com)
  • No patients with BCI had open repair, 4.24% had a carotid artery stent (CAS), and 95.76% of patients had no operative intervention. (dcorthoacademy.org)
  • Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. (jci.org)
  • After vascular injury by balloon angioplasty or stent implantation, diverse mechanisms are activated, leading to neointimal hyperplasia. (nature.com)
  • Coronary Artery Angioplasty with Stent Coronary artery angioplasty with stent facts, including who needs it. (vitals.com)
  • 250 ms. Signal-to-noise and contrast-to-noise-ratio (SNR, CNR) of the injured vessel wall was determined by manual segmentation of the visually apparent signal of the contrast agent below the carotid bifurcation. (biomedcentral.com)
  • Both patients had a low carotid bifurcation. (elsevier.com)
  • A low carotid bifurcation may be a risk factor for such injuries. (elsevier.com)
  • Using duplex ultrasound, a low invasive examination, information is obtained on the abdominal aortic diameter and the degree of stenosis of the carotid bifurcation. (bioportfolio.com)
  • Comparison of two methods for revascularization of the bifurcation of common carotid artery: carotid endarterectomy with longitudinal incision carotid endarterectomy patch angioplasty comp. (bioportfolio.com)
  • We report an unusual case of subarachnoid hemorrhage (SAH) caused by rupturing of the traumatic pseudoaneurysm of the internal carotid artery (ICA) bifurcation that resulted from a non-penetrating injury . (bvsalud.org)
  • (b) An 0.014″ guidewire is next inserted via the external carotid (EC) artery and traversed along the entire length of common carotid artery up to the carotid bifurcation for 1 minute (distal to head) to induce injury to the vessel. (nih.gov)
  • Endovascular Trapping of Large Cervical Carotid Pseudoaneurysm in Marfan Syndrome Presenting with Progressive Respiratory Distress. (harvard.edu)
  • BACKGROUND Carotid stenting has been advocated in patients with grade III blunt carotid artery injuries (hereafter referred to as 'blunt CAIs') because of the persistence of the pseudoaneurysm and concern for subsequent embolization or rupture. (semanticscholar.org)
  • Hemomediastinum with probably posttraumatic dissecting pseudoaneurysm of the right branch of the pulmonary artery, with no active bleeding. (imaios.com)
  • In a patient with severe headache and SAH in the right sylvian cistern , which developed within 7 days after a blunt-force head injury , a trans-femoral cerebral angiogram (TFCA) showed aneurysmal sac which was insufficient to confirm the pseudoaneurysm . (bvsalud.org)
  • We suggest that in the patient with a history of blunt head injury with SAH following shortly, multi-slab image of 3D TOF MRA can give visualization of the presence of a pseudoaneurysm . (bvsalud.org)
  • The bullet entered through the left anterior neck and severed the left common carotid artery. (biomedsearch.com)
  • Hundersmarck D, Reinders Folmer E, de Borst GJ, Leenen LPH, Vriens PWHE, Hietbrink F. Penetrating Neck Injury in Two Dutch Level 1 Trauma Centres: the Non-Existent Problem. (harvard.edu)
  • Penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures in the neck. (biomedsearch.com)
  • We experienced some cases with externally penetrating injuries in neck zone II in which the patients were confirmed to have the presence of large vessel injuries in neck zones I and III. (biomedsearch.com)
  • A penetrating trauma occurring in the neck can cause severe complications such as hemorrhage as the result of vascular injury, spinal cord injury, respiratory obstruction, and sepsis from esophageal injury. (biomedsearch.com)
  • In cases of penetrating injury occurring in zones I and III of the neck, the direct control of blood vessels is difficult. (biomedsearch.com)
  • Accordingly, unlike the situation in zone II of the neck, where the proximal and distal control of blood vessels can be easily achieved, angiography should be performed in cases of penetrating injury occurring in zones I and III. (biomedsearch.com)
  • 1 , 4 In cases of penetrating neck injury, however, the neck zone cannot be accurately differentiated by means of the external wound only. (biomedsearch.com)
  • A 22-year-old man sustained a strangulation-type injury to the neck, with bilateral blunt carotid artery injuries detected on computed tomography (CT) angiography. (scielo.org.za)
  • A CT angiogram of the neck vessels ( Fig. 1 ) showed total occlusion of the right ICA (grade IV injury) and a filling defect of the left ICA suggestive of an intimal flap (grade II injury). (scielo.org.za)
  • The most common mechanism of tCAD in pediatrics is either a direct blow to the neck, or head, or hyperextension, and MVAs are the most common causes of such injury. (signavitae.com)
  • runs superiorly in the neck and divides opposite upper border of thyroid cartilage (C-4 vertebral level) into terminal branches , external and internal carotid. (thefreedictionary.com)
  • one of the major arteries supplying blood to the head and neck. (thefreedictionary.com)
  • Branches of the external carotid supply the face, scalp, and most of the neck and throat tissues. (thefreedictionary.com)
  • in the neck, between the level of the top of the trachea and the floor of the mouth, each common carotid artery divides into an internal and an external carotid artery. (thefreedictionary.com)
  • These data suggest that internal carotid artery dissections may be underrecognized sequelae of direct softball injuries to the anterolateral neck. (elsevier.com)
  • Imagistic findings (magnetic resonance imaging of the brain, and cervical spine, and magnetic resonance angiography of the head and neck) indicated a very rare condition: left internal carotid artery agenesis accompanied by the absence of the pre-communicant part of the left anterior cerebral artery and of the right posterior communicating artery. (bioportfolio.com)
  • They most often result from accidental neck injuries, or from intraoperative insults in the context of oropharyngeal surgery, mostly tonsillectomy [ 1 ]. (hindawi.com)
  • Neck injury may result in the laceration of major vessels, potentially leading to hemorrhagic shock. (medscape.com)
  • From the time when Ambroise Pare successfully treated a neck injury in 1552, debate has continued about the best approach for particular neck wounds. (medscape.com)
  • Awareness of the various presentations of neck injuries and the establishment of a well-conceived multidisciplinary plan prior to the traumatic event is critical for improving patient outcome. (medscape.com)
  • The neck is divided into anatomic zones or regions to assist in the evaluation of neck injuries. (medscape.com)
  • These images are a random sampling from a Bing search on the term "Vertebral Artery Injury in Blunt Neck Trauma. (fpnotebook.com)
  • Sudden severe injury to the neck may also contribute to disc herniation, whiplash , blood vessel destruction, vertebral bone or ligament injury and, in extreme cases, permanent paralysis. (aans.org)
  • Surgery may also be necessary if the injury causes a narrowing of the spinal canal in your neck. (spineuniverse.com)
  • Carotid Artery Disease - Explanation of the complex anatomy of the carotid arteries, vessels in the neck that carry blood to the brain by Dr. Wang-Cheng, Professor of Medicine at the Medical College of Wisconsin. (searchbeat.com)
  • Neck injuries are rare but carry significant morbidity and mortality. (springer.com)
  • Due to relative head weight to neck strength and other anatomic differences, neck injury is more critical in the very young. (chiro.org)
  • After the neck has been evaluated, check possible injury to other parts of the body. (chiro.org)
  • Inflammatory cells are likely contributors in the host response to vascular injury, via cytokines and chemokines secretion, including TNF-alpha (TNF). (nih.gov)
  • Vascular injury and ReEndo was examined on day 7 by Evans blue perfusion method. (nih.gov)
  • Vinculin, a paxillin-binding protein, was not altered by vascular injury or by eNOS gene transfer. (ahajournals.org)
  • Blunt vertebral vascular injury in trauma patients: ATLS® recommendations and review of current evidence. (semanticscholar.org)
  • In certain cases, the endoscopic approach can preclude obtaining proximal control of the offending vascular injury and due to anatomic and technical constraints. (cureus.com)
  • Smooth muscle cell proliferation and extracellular matrix (ECM) synthesis/turnover are thought to play an important role in vessel wall repair after vascular injury. (biomedcentral.com)
  • Preliminary evaluation of the carotid wall thickening seem to confirm our MRI findings and suggests that targeted deletion of CRP2 in mice might lead to a reduced vessel wall thickening and thus to a reduced restenosis after vascular injury. (biomedcentral.com)
  • In this study, we demonstrate the successful use of molecular MRI for the non-invasive assessment of alterations in the vessel wall after vascular injury in a mouse model of impaired smooth muscle cell proliferation and ECM formation. (biomedcentral.com)
  • 1 Hence, 1 of the aims of the present study was to test the hypothesis that 2-ME can inhibit vascular injury-induced neointima formation. (ahajournals.org)
  • Background and Objectives: Clodronate liposomes deplete phagocytic cells, thereby suppressing inflammation after vascular injury. (elsevier.com)
  • Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. (jci.org)
  • No differences were detected between the tissue-specific cGKI mutants and control mice at different time points after vascular injury on a normolipidemic or apoE-deficient background. (nih.gov)
  • Exisulind significantly reduced VSMCs viability, cell cycle progression, migration, and neointimal hyperplasia after vascular injury in rat carotid arteries. (nature.com)
  • Re-endothelialization was quantified in Evans blue-stained carotid arteries at 3 and 7 days after vascular injury. (nature.com)
  • The abnormal immune response driven by SLE enhances vascular injury mechanism and weaken repair mechanism, breaking vascular dynamic balance which determines the occurrence of CVD ( Figure 1 ). (frontiersin.org)
  • This brand-new volume in the best-selling 'Case Review' series uses more than 200 case studies to challenge your knowledge of a full range of topics in emergency radiology, including MDCT-A of vascular injury, CT and MR of spinal injuries, CT and MRI of CNS emergencies, and subtle and classic CT signs of bowel emergencies. (indigo.ca)
  • Vascular injury should be suspected in patients with hard signs and evaluated further in patients with soft signs. (springer.com)
  • A prospective study for the detection of vascular injury in adult and pediatric patients with cervicothoracic seat belt signs. (springer.com)
  • Furie and colleagues have recently developed an intravital confocal and widefield microscopy system that allowed real-time in vivo imaging of platelet deposition, TF accumulation, and fibrin generation during thrombus formation following vascular injury in mice. (bloodjournal.org)
  • Methods and Results -We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the common carotid artery was assessed. (ahajournals.org)
  • Smooth muscle cells have been shown to express mRNA for urokinase plasminogen activator and tissue-type plasminogen activator after balloon injury in the rat model of angioplasty. (ahajournals.org)
  • This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by cardiovascular magnetic resonance (CMR) using a T2-weighted short-tau inversion recovery sequence (T2-STIR). (springer.com)
  • Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. (springer.com)
  • We examined the effect of bortezomib on neointima formation after of a rat carotid artery balloon injury. (bvsalud.org)
  • The systemic treatment group exhibited a 29% reduction in neointima volume at two weeks after the balloon injury. (bvsalud.org)
  • The whole rat genome microarray expression profiling of carotid artery specimen was emplyed to identify the gene expression profile before and after balloon injury. (datamed.org)
  • In our study, the neointimal formation of carotid arteries was apparent at day 7 and markedly increased at day 21 after balloon injury. (datamed.org)
  • Expression of four genes (TLR4, IRAK1, IκBα, IL-1β) from TLR signaling pathway was quantified in the same RNA samples by quantitative real-time PCR, conforming that TLR signaling pathway participated in neointimal formation of carotid arteries after balloon injury. (datamed.org)
  • Balloon injury-induced gene expression in wistar rat was measured at day 7 and day 21 after balloon injury as compared with uninjured arteries. (datamed.org)
  • Actinomycin D has been regarded as a potential candidate to prevent balloon injury-induced neointimal formation. (elsevier.com)
  • Here, we examined the effects of Exisulind on neointimal formation after balloon injury and its mechanisms of action in VSMCs, endothelial cells, and platelets. (nature.com)
  • The glucose transporter isoform, GLUT1, was significantly increased in the neointima after balloon injury. (diabetesjournals.org)
  • Indeed, the stenosis of the internal carotid artery can lead to ophthalmological charts. (clinicaltrials.gov)
  • The stenosis of the internal carotid artery is a frequent and potentially serious pathology (TIA, ischemic stroke, death), which can also be manifested by ophthalmological charts, foremost among which are transient monocular blindness. (clinicaltrials.gov)
  • The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared. (bioportfolio.com)
  • PURPOSE: To evaluate the in vivo alterations on ketone bodies metabolism after cerebral ischemia/reperfusion through an experimental model of brain ischemia induced by simple occlusion of common carotid arteries (CCAs) in Wistar rats. (scielo.br)
  • Cerebral ACT and BHB levels increased significantly in Group T after 30min of carotid occlusion (time 0). (scielo.br)
  • The partial transient acute global brain ischemia induced by the bilateral carotid occlusion in Wistar rats triggered ketogenesis probably due to a central stimulation of catecholamine secretion. (scielo.br)
  • Preferred techniques for the management of arterial injury during endoscopic surgery are a topic of debate and include direct cautery, clip ligation, tamponade with muscle or hemostatic agent, and endovascular treatments including occlusion, coiling, or stenting [1-5, 7-9] . (cureus.com)
  • A combination of bivalirudin (hirulog) plus a novel PAR4 pepducin antagonist, P4pal-i1, effectively inhibited aggregation of human platelets to even high concentrations of thrombin and prevented occlusion of carotid arteries in guinea pigs. (ahajournals.org)
  • Likewise, combined inhibition of PAR1 and PAR4 with small-molecule antagonists and pepducins was effective against carotid artery occlusion. (ahajournals.org)
  • Internal carotid artery agenesis is an uncommon congenital anomaly and it could be misdiagnosed as stenosis/occlusion of this artery. (bioportfolio.com)
  • He did well until 2006 when he was found to have a right internal carotid artery near total occlusion, most probably post radiation in origin, with a 40% contralateral stenosis. (hindawi.com)
  • Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice. (harvard.edu)
  • b ) Day 3 wire-injured carotid artery (A and B - 20 x). (c) Day 14 control carotid artery. (nih.gov)
  • Abstract The temporal relationship of matrix metalloproteinases (MMPs) and a specific tissue inhibitor (TIMP-1) has been examined by reverse transcription-polymerase chain reaction and substrate zymography, after balloon catheter angioplasty of the rat carotid artery. (ahajournals.org)
  • The role of carotid angioplasty and stenting in carotid revascularization. (naver.com)
  • 4. The method of claim 3, wherein said vascular interventional procedure is selected from the group consisting of angioplasty, coronary artery surgery and coronary artery stents. (google.com)
  • [4] Grade I and II injuries are of particular concern and require follow-up angiography owing to the risk of pseudo-aneurysm formation despite heparin therapy. (scielo.org.za)
  • Cerebral embolism, due to a traumatic aneurysm of the internal carotid artery, and a duodenal tear occurred in a young woman who was wearing a seat belt at the time of a motor car accident. (trb.org)
  • The aneurysm was treated by proximal carotid ligation. (trb.org)
  • Both abdominal aortic aneurysm (AAA) and carotid artery stenosis (CAS) are frequent clinical entities, with major morbidity and mortality. (bioportfolio.com)
  • Carotid Endarterectomy for Aneurysm - Step by Step - Step by step photos of a carotid aneurysm repair, a rather unusual surgery, provided by PVSS. (searchbeat.com)
  • Endovascular stenting for the treatment of traumatic internal carotid injuries: expanding experience. (semanticscholar.org)
  • His history is pertinent for a right internal carotid endovascular stenting 2 years prior to presentation. (hindawi.com)
  • He underwent consequently a right carotid artery angiography and endovascular stenting, and was started on anticoagulation. (hindawi.com)
  • High-resolution optical mapping of inflammatory macrophages following endovascular arterial injury. (nih.gov)
  • Here we utilize intravital microscopy (IVM) and a dextran-coated nanosensor to spatially map inflammatory macrophages in vivo following endovascular injury of murine carotid arteries. (nih.gov)
  • C57Bl/6 mice (n = 23) underwent endovascular guidewire carotid arterial injury. (nih.gov)
  • After finishing the craniotomy, the patient was immediately transferred to the angiography suite and cerebral angiography was performed in order to evaluate the condition of intracranial internal carotid artery (ICA). (signavitae.com)
  • The OCT-angiography technique accurately studies the retinal vasculature and also assesses the risk of retinal and choroidal embolism, which is recognized as increased in cases of symptomatic or asymptomatic carotid stenosis. (clinicaltrials.gov)
  • Wounds are injuries that break the skin or other body tissues. (icdlist.com)
  • Furthermore, seemingly innocuous wounds may not manifest clear signs or symptoms, and potentially lethal injuries could be easily overlooked or discounted. (medscape.com)
  • Carotid artery injury during endonasal surgery is the most feared and catastrophic complication. (edu.au)
  • Rowan NR , Turner MT, Valappil B, Fernandez-Miranda J, Wang EW, Gardner PA, Snyderman CH. Injury of the carotid artery during endoscopic endonasal surgery:surveys f skull base surgeons. (hopkinsmedicine.org)
  • IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. (nih.gov)
  • Here we report that in a mouse model of carotid denudation, IL-10 knock-out mice (IL-10KO) displayed significantly delayed Re-endothelialization and enhanced neo-intimal growth compared to their WT counterparts. (nih.gov)
  • After carotid artery balloon denudation, bortezomib was immediately administered by tail vein injection (systemic treatment) and by using an F-127 pluronic gel (perivascular treatment). (bvsalud.org)
  • Does carotid stenting measure up to endarterectomy? (semanticscholar.org)
  • Carotid Endarterectomy and Carotid Artery Stenting in the Light of ICSS and CREST Studies. (bioportfolio.com)
  • We analyzed the results of internal carotid artery (ICA) stenosis treatment at our institution according to the treatment modality-carotid endarterectomy (CEA) vs. carotid artery stenting (CAS). (bioportfolio.com)
  • Carotid Endarterectomy Surgery Step by Step - Photographs of carotid endarterectomy surgery. (searchbeat.com)
  • Diagnosis and Management of Carotid Artery Occlusive Disease - Plan for preoperative evaluation of a patient before carotid endarterectomy. (searchbeat.com)
  • In this study we investigated whether the use of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury and whether it would facilitate the detection of impaired ECM formation in CRP2-/- mice. (biomedcentral.com)
  • In order to investigate the underlying mechanism of neointimal formationin in injured carotid arteries, all genes involved in signaling pathways whose expression was altered 2-fold in injured carotid arteries at day 7 and day 21 as compared to uninjured arteries were filtered out. (datamed.org)
  • Temporal control of drug delivery may facilitate endothelial healing after injury, as NPs may be used to deliver antiproliferative agents to the vascular wall when neointimal proliferation is most active, followed by complete degradation and clearance ( 18 ). (pnas.org)
  • Clodronate (0.1 mL/10 g) was injected via the tail vein starting 2 days (d-2) before left common carotid artery injury. (elsevier.com)
  • Conclusions -Diet-induced hyperhomocysteinemia, even mild to moderate, exacerbates neointima formation after denuding injury, making hyperhomocysteinemia a likely risk factor for postangioplasty restenosis. (ahajournals.org)
  • Abstract -Injury-caused dedifferentiation accompanied by proliferation and migration of smooth muscle cells (SMCs) is an important process in the development of the neointima. (ahajournals.org)
  • Two weeks after the injury, we compared the degree of neointima formation in the carotid artery and the tissue expression patterns of NF-kappaB and I-kappaBalpha. (bvsalud.org)
  • Bortezomib suppressed NF-kappaB activation through the inhibition of I-kappaBalpha degradation, and significantly reduced neointima formation in a rat carotid artery injury model. (bvsalud.org)
  • Here we studied the intracellular mechanisms by which 2-ME inhibits SMC growth and whether 2-ME prevents injury-induced neointima formation. (ahajournals.org)
  • Antimitotic therapies used in cancer may also protect against vascular disorders 4 because abnormal growth of vascular smooth muscles (SMCs) contributes to vascular remodeling, such as neointima formation, atherosclerosis, and injury-induced restenosis. (ahajournals.org)
  • In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. (jci.org)
  • Zurück zum Zitat Solares CA, Ong YK, Carrau RL, Fernandez-Miranda J, Prevedello DM, Snyderman CH, Kassam AB (2010) Prevention and management of vascular injuries in endoscopic surgery of the sinonasal tract and skull base. (springermedizin.de)
  • Zurück zum Zitat Weidenbecher M, Huk WJ, Iro H (2005) Internal carotid artery injury during functional endoscopic sinus surgery and its management. (springermedizin.de)
  • Zurück zum Zitat Koitschev A, Simon C, Lowenheim H, Naeqele T, Ernemann U (2006) Management and outcome after internal carotid artery laceration during surgery of the paranasal sinuses. (springermedizin.de)
  • Arterial injuries are the most feared complication of endoscopic skull base surgery. (cureus.com)
  • Internal carotid artery injury is more frequent during skull base surgery, and risk factors include acromegaly, previous revision surgery, and prior radiotherapy and bromocriptine therapy. (edu.au)
  • The mortality rate for the series was 23%, but only 14% in the patients who had carotid surgery. (elsevier.com)
  • Prevedello, Daniel M. / Training model for control of an internal carotid artery injury during transsphenoidal surgery . (fujita-hu.ac.jp)
  • Also, it has a special importance in case of planning carotid or trans-sphenoidal hypophyseal surgery. (bioportfolio.com)
  • Stroke Prevention - Carotid artery surgery in easy to understand text with nice graphics. (searchbeat.com)
  • Blunt cerebrovascular injury practice management guidelines: the Eastern Association for the Surgery of Trauma. (springer.com)
  • This experience suggests that repair is safe and effective in patients with carotid injuries in whom prograde flow continues and only mild neurologic deficits are present. (elsevier.com)
  • Time to stroke: A Western Trauma Association multicenter study of blunt cerebrovascular injuries. (harvard.edu)
  • A beneficial effect of anticoagulation therapy with unfractionated heparin has been demonstrated, with a reduction of the ischaemic stroke rate from 29.8% to 3.9% [7] in grade I - IV injuries. (scielo.org.za)
  • Inflammation plays an essential role for destabilization and rupture of carotid atherosclerotic plaques causing embolic ischemic stroke. (springer.com)
  • Associated injuries included long bone fractures (28.5%), stroke and intracranial hemorrhage (28.5%), cranial injuries (25.6%), thoracic injuries (23.6%), cervical fractures (21.8%), facial fractures (19.9%), skull fractures (18.8%), pelvic fractures (18.5%), hepatic (13.3%) and splenic (9.2%) injuries. (dcorthoacademy.org)
  • Frequently associated injuries were long bone fractures, stroke and intracranial hemorrhage, thoracic injuries, and pelvic fractures which are likely associated with the force/mechanism of injury. (dcorthoacademy.org)
  • Glasgow Coma Score (GCS) of 12 or less, or stroke with hemi-paresis signifying a moderate to severe acquired brain injury . (tripdatabase.com)
  • Spinal manipulation has been suggested as a potential cause of cerebrovascular accidents (eg, stroke) through mechanical injury to the vertebral artery. (aappublications.org)
  • The vertebral artery supplies the part of the brain that lies in the posterior fossa of the skull, and this type of stroke is therefore called a posterior circulation infarct . (wikipedia.org)
  • Carotid Artery Disease - Features information about the disease and the increased risk it brings for stroke. (searchbeat.com)
  • When to Operate in Carotid Artery Disease - When to operate in carotid artery disease by Jose Biller, M.D. and William H. Thies, PH.D. American Academy of Family Physicians present the recent stroke trials in language we can all understand. (searchbeat.com)
  • Ocular Manifestations of Carotid Artery Disease - A specific type of vision problem is one of the classic signs of a TIA (transitory ischemic attack) which is frequently a precursor to a stroke. (searchbeat.com)
  • abstract = "Objectives: As the adoption of endoscopic endonasal approaches (EEA) continues to proliferate, increasing numbers of internal carotid artery (ICA) injuries are reported. (fujita-hu.ac.jp)
  • Blunt carotid arterial injury (BCI) is a rare injury associated with motor vehicle collision (MVC). (dcorthoacademy.org)
  • The purpose of the study was to investigate the rare condition of blunt carotid arterial injury (BCI) associated with blunt trauma with MVC using a population based approach considering the associated injuries and outcomes. (dcorthoacademy.org)
  • The unrecognized epidemic of blunt carotid arterial injuries: early diagnosis improves neurologic outcome. (springer.com)
  • Moreover, recent work from our laboratory has demonstrated that hyperglycemia inhibits medial VSMC apoptosis in the murine carotid artery in response to a reduction in blood flow ( 10 ). (diabetesjournals.org)
  • Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits. (semanticscholar.org)
  • Part II: blunt cerebrovascular injury. (semanticscholar.org)
  • Blunt carotid and vertebral artery injury, collectively termed blunt cerebrovascular injury, are rare but potentially devastating events. (uptodate.com)
  • Injury mechanisms, screening, and diagnosis of blunt cerebrovascular injury will be reviewed here. (uptodate.com)
  • The treatment of blunt cerebrovascular injury is discussed separately. (uptodate.com)
  • See 'Blunt cerebrovascular injury: Treatment and outcomes' . (uptodate.com)
  • The anatomic variability of the collateral circulation helps explain the clinical presentations of patients with cerebrovascular injuries, and underscores the need for complete imaging of cerebral circulation when injury is suspected. (uptodate.com)
  • Screening for blunt cerebrovascular injuries: analysis of diagnostic modalities and outcomes. (springer.com)
  • Optimizing screening for blunt cerebrovascular injuries. (springer.com)
  • Extracranial arterial injuries to the brachiocephalic, common carotid, and vertebral arteries can result in major neurologic deficits. (medscape.com)
  • The vascular supply to the brain is divided into the anterior and posterior circulations originating from the carotid and vertebral arteries, respectively. (uptodate.com)
  • During resection of the middle fossa component of a large ventral skull base chondrosarcoma, arterial bleeding was encountered near the right internal carotid artery (ICA). (cureus.com)
  • Back in January 2014, I somehow managed to tear my right right internal carotid artery. (medhelp.org)
  • The morbidity and mortality of carotid arterial injuries in 36 patients were retrospectively reviewed. (elsevier.com)
  • Lucas, Charles E. / Primary Repair vs Ligation for Carotid Artery Injuries . (elsevier.com)
  • (h) Permanent ligation of the EC, followed by release of the clamp and return of blood flow through the IC artery. (nih.gov)
  • We investigated whether the absence of cGKI in SMCs would affect vascular remodeling after carotid ligation or removal of the endothelium. (nih.gov)
  • Cell adhesion molecules in coronary artery disease (1994) Jang Yangsoo et al. (naver.com)
  • Following recent successes with percutaneous coronary intervention (PCI) for treating coronary artery disease (CAD), many challenges remain. (pnas.org)
  • Each divides into an external carotid and an internal carotid. (thefreedictionary.com)
  • External carotid artery (ECA) stenosis is an independent mortality predictor. (bioportfolio.com)
  • objectives: Dura of the anterior clinoid process (ACP) is presumably supplied by the ophthalmic and external carotid artery branches. (bioportfolio.com)
  • EC = external carotid artery, IC = internal carotid artery, CC = common carotid artery. (nih.gov)
  • The greatest changes in ketone bodies metabolism were verified at initial minutes of recirculation as a result of the reperfusion injury phenomenon. (scielo.br)
  • Angpt2 was highly expressed in endothelial cells at the infarct border zone after myocardial infarction (MI) or ischemia/reperfusion injury in mice. (jci.org)
  • Carotid injury was performed in WT and IL-10 KO mice by wire injury method. (nih.gov)
  • A-B) Mice were injected with Evans blue (0.5%) 2-4h before euthanasia and carotid artery were isolated and visualized for endothelium integrity. (nih.gov)
  • Enhanced leakage of Evans blue dye from artery in IL-10 KO mice suggested that IL-10 depletion impaired vascular repair. (nih.gov)
  • IL-10 KO mice showed excessive intimal hyperplasia after wire injury. (nih.gov)
  • At day 14 or day 28 post-injury, mice underwent fluorescence IVM, 24 h after injection with the near-infrared fluorescent macrophage nanosensor CLIO-VT680. (nih.gov)
  • e , f ) Representative photomicrographs of immunohistochemical staining (scale bar, 25 μm) ( e ) and averaged data ( f ) showing the percentages of PCNA-positive cells in carotid arteries from Srsf1 −/− and WT control mice 14 and 28 days after wire injury. (nature.com)
  • IL-10 deletion reduces ReEndo and increases neo-intimal hyperplasia after carotid artery injury. (nih.gov)
  • C-D) For morphometric analysis, 28 days after injury carotid artery were isolated and neo-intimal hyperplasia was measured by Elastic Trichome (ET) staining. (nih.gov)
  • ReEndo and intimal hyperplasia in the denuded mouse carotid arteries was measured after IL-10 or IgG (50μg/kg each) ( A ) Representative photomicrographs of Evans blue stained arteries. (nih.gov)
  • These results suggest that NO inhibition of intimal hyperplasia may be mediated by enhancing the recovery of injury-caused downregulation of paxillin. (ahajournals.org)
  • Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation. (bioportfolio.com)
  • Although cerebral artery dissections are potentially fatal, there is still a lack of knowledge related to their natural history and adequate treatment options. (signavitae.com)
  • Four patients with traumatic internal carotid artery dissections were identified during the 8- year period under study. (elsevier.com)
  • Figure 1 Imbalance of injury/protection mechanism of SLE arteriosclerosis. (frontiersin.org)
  • Restenosis is thought to be a complex response to injury, which includes early thrombus formation, acute inflammation and neo-intimal growth. (nih.gov)
  • Inflammation following arterial injury mediates vascular restenosis, a leading cause of cardiovascular morbidity. (nih.gov)
  • To further investigate the effect of Yiqihuoxuejiedu formula on inflammation and connexins, we established a carotid artery injury model. (hindawi.com)
  • the right common carotid is a branch of the brachiocephalic artery. (thefreedictionary.com)
  • Injuries to the internal carotid artery are not common. (hindawi.com)
  • Fifth, readmission to the ICU is common as this patient population often requires additional reconstructive procedures after they have recovered from the initial injury. (clinicaladvisor.com)
  • The purpose of this study is to describe the changes in morphology and Retinal vascularization after revascularization of the internal carotid artery. (clinicaltrials.gov)
  • The underlying hypothesis is that revascularization of the internal carotid artery would improve ipsilateral and retinal homolateral perfusion in the short term. (clinicaltrials.gov)
  • Carotid revascularization procedures are performed for more than 87% of cases in patients with asymptomatic internal carotid stenosis (ICS), who are assumed to have a life expectancy of at. (bioportfolio.com)
  • To code a diagnosis of this type, you must use specify a 7th character that describes the diagnosis 'injury of r int carotid, intcr w loc of 31-59 min' in more detail. (icd.codes)
  • Esophageal injuries are difficult to predict and carry a high mortality when there is a delay to diagnosis. (springer.com)
  • Usefulness of the 3-dimensionally reconstructed computed tomography imaging for diagnosis of the site of tracheal injury (3D-tracheography). (springer.com)
  • head (Arteries and veins of the head) aorta (Branches of aorta) heart (The heart) for illus. (thefreedictionary.com)
  • It includes the arteries, veins and capillaries that carry blood to and from the heart. (icdlist.com)
  • Division of the middle thyroid and facial veins will facilitate complete visualization the carotid artery, which lies deep and medial to the internal jugular vein. (brainscape.com)
  • Previously, we reported the engineering of collagen IV-targeting nanoparticles (NPs) and demonstrated their preferential localization to sites of arterial injury. (pnas.org)
  • We demonstrate that the macrophage response to arterial injury can be imaged in vivo using IVM-based molecular imaging, and shows a higher macrophage influx at day 14 compared to day 28 post-injury. (nih.gov)
  • Arteries can become thick and stiff, a problem called atherosclerosis. (icdlist.com)
  • Previous studies have identified a relationship between snoring, carotid intima media thickening, and the presence of atherosclerosis. (bioportfolio.com)