Carotid Artery Injuries
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Carotid Arteries
Carotid Artery, Internal
Carotid Artery Thrombosis
Carotid Artery, Common
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Neck Injuries
Carotid Artery Diseases
Tunica Intima
Wounds, Nonpenetrating
Carotid Stenosis
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Neointima
Hyperplasia
Carotid Artery, External
Endarterectomy, Carotid
Vascular System Injuries
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
Vertebral Artery
Wounds and Injuries
Carotid Artery, Internal, Dissection
Rats, Sprague-Dawley
Carotid Body
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
Subclavian Artery
Carotid Sinus
Stents
Iatrogenic Disease
Wounds, Gunshot
Iliac Artery
Cells, Cultured
Tunica Media
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
Pulmonary Artery
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Treatment Outcome
Tomography, X-Ray Computed
Cerebral Angiography
Carotid Intima-Media Thickness
Axillary Artery
Aneurysm, False
Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.
Brachiocephalic Trunk
Catheterization
Basilar Artery
Ultrasonography, Doppler, Duplex
Arterial Occlusive Diseases
Mesenteric Arteries
Angioplasty, Balloon
Reperfusion Injury
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Arteriovenous Fistula
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
Magnetic Resonance Angiography
Arteriosclerosis
Spinal Cord Injuries
Disease Models, Animal
Endarterectomy
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Angiography, Digital Subtraction
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Angioplasty
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
Intraoperative Complications
Brain Ischemia
Risk Factors
Coronary Artery Bypass
Popliteal Artery
Radial Artery
Cerebrovascular Trauma
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Endothelium, Vascular
Follow-Up Studies
Cerebrovascular Disorders
Brachial Artery
Accidents, Traffic
Blood Vessel Prosthesis Implantation
Middle Cerebral Artery
Prospective Studies
Ophthalmic Artery
Myocytes, Smooth Muscle
Mammary Arteries
Aneurysm
Ultrasonography
Intracranial Embolism
Blood Flow Velocity
Atherosclerosis
Ultrasonography, Doppler, Color
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
Anastomosis, Surgical
Injury Severity Score
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Intracranial Arteriosclerosis
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Ultrasonography, Doppler, Transcranial
A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.
Intracranial Aneurysm
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Circle of Willis
A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.
Hematoma
Carotid Body Tumor
Lung Injury
Temporal Arteries
Vasodilation
Intracranial Embolism and Thrombosis
Cerebral Revascularization
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Amaurosis Fugax
Splenic Artery
Ultrasonography, Doppler
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
Constriction, Pathologic
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Postoperative Complications
Hemodynamics
Retinal Artery Occlusion
Embolization, Therapeutic
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Cavernous Sinus
Hepatic Artery
Rabbits
Jugular Veins
Severity of Illness Index
Eye Injuries
Celiac Artery
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Vasoconstriction
Magnetic Resonance Imaging
Cervical Vertebrae
Risk Assessment
Mesenteric Artery, Superior
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
Cranial Nerve Injuries
Infarction, Middle Cerebral Artery
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Endothelial implants inhibit intimal hyperplasia after porcine angioplasty. (1/784)
The perivascular implantation of tissue-engineered endothelial cells around injured arteries offers an opportunity to study fundamental vascular physiology as well as restore and improve tissue function. Cell source is an important issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the clinical applications of tissue-engineered grafts. We investigated the biological and immunological responses to endothelial cell xenografts and allografts in pigs 4 weeks after angioplasty of the carotid arteries. Porcine or bovine aortic endothelial cells were cultured within Gelfoam matrices and implanted in the perivascular space of 42 injured arteries. Both porcine and bovine endothelial cell grafts reduced the restenosis index compared with control by 54% and 46%, respectively. Perivascular heparin release devices, formulated to release heparin at twice the rate of release of heparan sulfate proteoglycan from endothelial cell implants, produced no significant reduction in the restenosis index. Endothelial cell implants also reduced occlusive thrombosis compared with control and heparin release devices. Host immune responses to endothelial implants were investigated by immunohistochemical examination of explanted devices and by immunocytochemistry of serum samples. The bovine cell grafts displayed infiltration of leukocytes, consisting primarily of lymphocytes, and caused an increase in antibodies detected in serum samples. Reduced cellular infiltration and no humoral response were detected in animals that received allografts. Despite the difference in immune response, the biological effects of xenografts or allografts did not differ significantly. (+info)Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. (2/784)
Prostacyclin (PGI2), a metabolite of arachidonic acid, has the vasoprotective effects of vasodilation, anti-platelet aggregation, and inhibition of smooth muscle cell proliferation. We hypothesized that an overexpression of endogenous PGI2 may accelerate the recovery from endothelial damage and inhibit neointimal formation in the injured artery. To test this hypothesis, we investigated in vivo transfer of the PGI2 synthase (PCS) gene into balloon-injured rat carotid arteries by a nonviral lipotransfection method. Seven days after transfection, a significant regeneration of endothelium was observed in the arteries transfected with a plasmid carrying the rat PCS gene (pCMV-PCS), but little regeneration was seen in those with the control plasmid carrying the lacZ gene (pCMV-lacZ) (percent luminal circumference lined by newly regenerated endothelium: 87. 1+/-6.9% in pCMV-PCS-transfected vessels and 6.9+/-0.2% in pCMV-lacZ vessels, P<0.001). BrdU staining of arterial segments demonstrated a significantly lower incorporation in pCMV-PCS-transfected vessels (7. 5+/-0.3% positive nuclei in vessel cells) than in pCMV-lacZ (50. 7+/-9.6%, P<0.01). Moreover, 2 weeks after transfection, the PCS gene transfer resulted in a significant inhibition of neointimal formation (88% reduction in ratio of intima/media areas), whereas medial area was similar among the groups. Arterial segments transfected with pCMV-PCS produced significantly higher levels of 6-keto-PGF1alpha, the main metabolite of PGI2, compared with the segments transfected with pCMV-lacZ (10.2+/-0.55 and 2.1+/-0.32 ng/mg tissue for pCMV-PCS and pCMV-placZ, P<0.001). In conclusion, this study demonstrated that an in vivo PCS gene transfer increased the production of PGI2 and markedly inhibited neointimal formation with accelerated reendothelialization in rat carotid arteries after balloon injury. (+info)Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation. (3/784)
The aim of this study was to evaluate whether vascular remodeling and neointimal thickening occur after balloon dilatation of the nonatherosclerotic rabbit carotid artery, and whether both processes are influenced by continuous perivascular delivery of L-arginine or the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). In the first experiment, histological and morphometric evaluation of arteries was performed at different time points after balloon dilatation: 10 minutes (n=7), and 1 (n=7), 2 (n=9), 3 (n=20), or 10 (n=5) weeks. Neointimal thickening progressively contributed to luminal narrowing for at least 10 weeks after angioplasty. During the first 2 weeks after dilatation, a significant decrease of the total vessel area was measured. Ten weeks after dilatation, both the neointimal and total vessel area were increased without further changing of the luminal area. In the second experiment, endothelial injured rabbits were randomly assigned to receive 2 weeks of continuous local perivascular physiological salt solution (n=6), L-arginine (n=8), or L-NAME (n=7), starting immediately after balloon dilatation (ie, local drug delivery during the first phase of the biphasic vascular remodeling process). Perivascular L-arginine delivery significantly reduced the neointimal area, despite an increased number of neointimal Ki-67-positive smooth muscle cells. Both the luminal area and total vessel area were significantly increased. Serum L-arginine levels remained unchanged. L-NAME administration had no effect on the neointimal area, nor on the luminal and total vessel area. Neointimal formation and biphasic vascular remodeling occur after experimental balloon dilatation of the nonatherosclerotic rabbit carotid artery, and can be influenced by continuous local perivascular delivery of L-arginine. (+info)TIMP-4 is regulated by vascular injury in rats. (4/784)
The role of basement membrane-degrading matrix metalloproteinases (MMPs) in enabling vascular smooth muscle cell migration after vascular injury has been established in several animal models. In contrast, the role of their native inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), has remained unproven despite frequent coregulation of MMPs and TIMPs in other disease states. We have investigated the time course of expression and localization of TIMP-4 in rat carotid arteries 6 hours, 24 hours, 3 days, 7 days, and 14 days after balloon injury by in situ hybridization, immunohistochemistry, and Western blot analysis. TIMP-4 protein was present in the adventitia of injured carotid arteries from 24 hours after injury. At 7 and 14 days after injury, widespread immunostaining for TIMP-4 was observed throughout the neointima, media, and adventitia of injured arteries. Western blot analysis confirmed the quantitative increase in TIMP-4 protein at 7 and 14 days. In situ hybridization detected increased expression of TIMP-4 as early as 24 hours after injury and a marked induction in neointimal cells 7 days after injury. We then studied the effect of TIMP-4 protein on the migration of smooth muscle cells through a matrix-coated membrane in vitro and demonstrated a 53% reduction in invasion of rat vascular smooth muscle cells. These data and the temporal relationship between the upregulation of TIMP-4, its accumulation, and the onset of collagen deposition suggest an important role for TIMP-4 in the proteolytic balance of the vasculature controlling both smooth muscle migration and collagen accumulation in the injured arterial wall. (+info)The role of alpha and beta platelet-derived growth factor receptor in the vascular response to injury in nonhuman primates. (5/784)
Restenosis remains a significant clinical problem associated with mechanical interventional procedures for arterial revascularization or repair, including coronary angioplasty and stenting. Studies with rodents have established that platelet-derived growth factor (PDGF), a potent chemotactic and mitogenic agent for vascular smooth muscle cells, is a key mediator of lesion formation after vascular injury. To further explore this hypothesis in a more clinically relevant model, neutralizing monoclonal antibodies (mAbs) were used to examine the effect of selective inhibition of alpha or beta PDGF receptor (PDGFR) on neointima formation in nonhuman primates. Carotid arteries were injured by surgical endarterectomy and femoral arteries by balloon catheter dilatation. Immunostaining revealed that both injuries induced cell proliferation and the upregulation of beta PDGFR but not alpha PDGFR. By 7 days after injury, beta PDGFR staining was limited to the luminal region of the media, the small areas of neointima, and the adventitia. Nearly all bromodeoxyuridine-positive cells were found in these regions as well. After 30 days, a concentric neointima that stained strongly for beta PDGFR had formed in the carotid and femoral arteries. Treatment of baboons with anti-beta PDGFR mAb 2A1E2 for 6 days after injury reduced the carotid artery and femoral artery lesion sizes by 37% (P<0.05) and 48% (P<0.005), respectively, when measured at 30 days. Under the same conditions, treatment with anti-alpha PDGFR mAb 2H7C5 had no effect. These findings suggest that PDGF mediates neointima formation through the beta PDGFR, and that antagonism of this pathway may be a promising therapeutic strategy for reducing clinical restenosis. (+info)Glucocorticoid resistance caused by reduced expression of the glucocorticoid receptor in cells from human vascular lesions. (6/784)
Mechanisms that control the balance between cell proliferation and death are important in the development of vascular lesions. Rat primary smooth muscle cells were 80% inhibited by low microgram doses of hydrocortisone (HC) and 50% inhibited by nanogram concentrations of transforming growth factor-beta1 (TGF-beta1), although some lines acquired resistance in late passage. However, comparable doses of HC, or TGF-beta1, failed to inhibit most human lesion-derived cell (LDC) lines. In sensitive LDC, HC (10 microg/mL) inhibited proliferation by up to 50%, with obvious apoptosis in some lines, and TGF-beta1 inhibited proliferation by more than 90%. Collagen production, as measured by [3H]proline incorporation or RIA for type III pro-collagen, was either unaffected or increased in the LDCs by HC. These divergent responses between LDC lines were partially explained by the absence of the glucocorticoid receptor (GR) and heat shock protein 90 mRNA in 10 of 12 LDC lines, but the presence of the mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II. Western blot analysis confirmed the absence of the GR protein in cells lacking GR mRNA. Immunohistochemistry of human carotid lesions showed high levels of GR in the tunica media, but large areas lacking GR in the fibrous lesion. Considering the absence of the GR in most lines, the effects of HC may be elicited through the mineralocorticoid receptor. Functional resistance to the antiproliferative and antifibrotic effects of HC may contribute to excessive wound repair in atherosclerosis and restenosis. (+info)Apoptosis and Bcl-xs in the intimal thickening of balloon-injured carotid arteries. (7/784)
We performed balloon injury in the rat carotid artery and identified intimal thickening after injury. Balloon-injured carotid arteries showed maximum thickness of the neointima on the 14th day before complete endothelial cell regeneration. In this lesion we identified apoptosis of vascular smooth muscle cells (VSMCs) by in situ DNA labelling and electron microscopy in the neointima on the 14th day after injury. mRNA expression levels of bcl-2, bax, bcl-x, p53 and caspase-1 were determined by the reverse transcriptase-polymerase chain reaction method both in injured and uninjured carotid arteries. Neither bcl-2 nor bcl-xl mRNA expression was detected in either injured or uninjured arteries, whereas bax and p53 mRNA expression was identified and their mRNA levels were not altered after balloon injury. In contrast, both bcl-xs and caspase-1 mRNA was detected and was markedly induced only in the injured carotid artery. Positive staining for immunoreactive Bcl-x was observed specifically in the injured arterial wall and co-localized with positive staining of nuclei identified by in situ DNA labelling. We conclude that two opposite cellular responses, VSMC proliferation and apoptosis, exist together in the neointima of the rat carotid artery after balloon injury, and selective induction of Bcl-xs expression is a key regulator of VSMC apoptosis in the process of vascular remodelling. (+info)Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. (8/784)
Using the rat balloon catheter denudation model, we examined the role of transforming growth factor-beta (TGF-beta) isoforms in vascular repair processes. By en face in situ hybridization, proliferating and quiescent smooth muscle cells in denuded vessels expressed high levels of mRNA for TGF-beta1, TGF-beta2, TGF-beta3, and lower levels of TGF-beta receptor II (TGF-betaRII) mRNA. Compared with normal endothelium, TGF-beta1 and TGF-beta2, as well as TGF-betaRII, mRNA were upregulated in endothelium at the wound edge. Injected recombinant soluble TGF-betaRII (TGF-betaR:Fc) localized preferentially to the adventitia and developing neointima in the injured carotid artery, causing a reduction in intimal lesion formation (up to 65%) and an increase in lumen area (up to 88%). The gain in lumen area was largely due to inhibition of negative remodeling, which coincided with reduced adventitial fibrosis and collagen deposition. Four days after injury, TGF-betaR:Fc treatment almost completely inhibited the induction of smooth muscle alpha-actin expression in adventitial cells. In the vessel wall, TGF-betaR:Fc caused a marked reduction in mRNA levels for collagens type I and III. TGF-betaR:Fc had no effect on endothelial proliferation as determined by reendothelialization of the denuded rat aorta. Together, these findings identify the TGF-beta isoforms as major factors mediating adventitial fibrosis and negative remodeling after vascular injury, a major cause of restenosis after angioplasty. (+info)
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His injuries include: Amputation of both arms and both legs; Severed left carotid artery; Broken nose, left eye socket and ... As a result of the EFP entering the vehicle through his door, he sustained severe, permanent and life changing injuries. ... resulting in one fatality and two injuries. ...
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Cerebral hyperperfusion syndrome
... and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting". ... The first symptom is usually severe headache, and a headache in the setting of recent carotid endarterectomy or carotid ... usually following treatment of carotid artery stenosis. Risk factors include hypertension, particularly high blood pressures in ... Kirchoff-Torres, KF; Bakradze, E (19 March 2018). "Cerebral Hyperperfusion Syndrome After Carotid Revascularization and Acute ...
Murder of Karina Vetrano
Margaret Prial, who performed Vetrano's autopsy, described her injuries, including a compressed carotid artery in her neck. The ... She ran alone, despite the expressed concerns of her father, her usual running partner, who was suffering from a back injury. ... and that he had also suffered a hand injury. Lewis's family continued to deny his involvement in the homicide. His father ...
Basilar skull fracture
Acute injury to the internal carotid artery (carotid dissection, occlusion, pseudoaneurysm formation) may be asymptomatic or ... Involvement of the petrous segment of the carotid canal is associated with a relatively high incidence of carotid injury. ... They are almost exclusively observed when the carotid canal is fractured, although only a minority of carotid canal fractures ... Pediatric Head Trauma at eMedicine Skull Fracture at eMedicine "About Brain Injury". Brain Injury Association of America. ...
Mandibular fracture
Other rare complications of mandibular trauma include internal carotid artery injury, and obliteration of the ear canal due to ... Finally, vascular injury can result (with particular attention to the internal carotid and jugular) from high velocity injuries ... The same injury can be seen on the opposite side 3D CT reconstruction of mandible fracture, white arrow marks fracture, red ... In high velocity injuries, the soft tissue can be severely damaged far from the bullet wound itself due to hydrostatic shock. ...
Dallas Taylor (vocalist)
Taylor was hospitalized for a serious ATV accident in which he suffered a severe brain injury and trauma to the carotid artery ...
Suicide by hanging
... and carotid artery injury. Ron M. Brown writes that hanging has a "fairly imperspicuous and complicated symbolic history". ... About 11 lb of pressure is required to compress the carotid artery; 4.4 lb for the jugular veins; and at least 15 kg for the ... compression of the carotid arteries, the jugular veins, or the airway. ... Cervical spine fractures are rare unless the hanging is a drop hanging, which usually causes an injury known as hangman's ...
Vertebral artery dissection
... or whiplash injury.[7] 1-2% of those with major trauma may have an injury to the carotid or vertebral arteries.[2] In many ... The other type, carotid artery dissection, involves the carotid arteries. Vertebral artery dissection is further classified as ... Vertebral artery dissection is less common than carotid artery dissection (dissection of the large arteries in the front of the ... or for symptoms of carotid artery dissection to occur at the same time as those of vertebral artery dissection.[2] Some give a ...
Hanging
... and carotid artery injury. There are some suggestions that the Vikings practiced hanging as human sacrifices to Odin, to honour ... A hanging may induce one or more of the following medical conditions, some leading to death: Closure of carotid arteries ... Where death has occurred through carotid artery obstruction or cervical fracture, the face will typically be pale in colour and ... Compromise of the cerebral blood flow may occur by obstruction of the carotid arteries, even though their obstruction requires ...
List of MeSH codes (C10)
... carotid artery thrombosis MeSH C10.228.140.300.200.345 - carotid artery injuries MeSH C10.228.140.300.200.345.300 - carotid ... carotid artery injuries MeSH C10.900.250.300.300 - carotid artery, internal, dissection MeSH C10.900.250.300.400 - carotid- ... carotid artery injuries MeSH C10.228.140.300.350.500.300 - carotid artery, internal, dissection MeSH C10.228.140.300.350.500. ... carotid artery, internal, dissection MeSH C10.228.140.300.200.360 - carotid stenosis MeSH C10.228.140.300.200.490 - carotid- ...
Suicide by hanging
... and carotid artery injury.[5] Ron M. Brown writes that hanging has a "fairly imperspicuous and complicated symbolic history".[6 ... compression of the carotid arteries, the jugular veins, or the airway.[16][17] About 11 lb (5 kg) of pressure is required to ... compress the carotid artery; 4.4 lb (2 kg) for the jugular veins;[16] and at least 15 kg (33 lb) for the airway.[18] The amount ... Hanna, S.J (2004). "A study of 13 cases of near-hanging presenting to an Accident and Emergency Department". Injury. 35 (3): ...
Carotid artery dissection
The probable mechanism of injury for most internal carotid injuries is rapid deceleration, with resultant hyperextension and ... The incidence of spontaneous carotid artery dissection is low, and incidence rates for internal carotid artery dissection have ... Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing blood to the head and brain ... which stretches the internal carotid artery over the upper cervical vertebrae, producing an intimal tear. After such an injury ...
Darlie Routier
Her wounds, described as superficial, came within two millimeters of her carotid artery. Routier was treated at a hospital and ... They also stated that, despite her injuries, Routier's blood was not found in the garage or anywhere outside the home. The ... medical examiner Vincent DiMaio testified that the wound to Routier's neck came within two millimeters of her carotid artery ... During the trial, the prosecution argued that Routier's injuries were self-inflicted, that the crime scene had been staged, and ...
Superior thyroid artery
This artery branches from the superior thyroid artery near its bifurcation from the external carotid artery. Together with the ... making it at risk for injury during surgery. Inferior thyroid artery Diagram showing the origins of the main branches of the ... The superior thyroid artery arises from the external carotid artery just below the level of the greater cornu of the hyoid bone ... carotid arteries. The internal carotid and vertebral arteries. Right side. (Superior thyroid visible at center.) The thyroid ...
Carotid endarterectomy
Contralateral laryngeal nerve injury. Tracheostoma. Carotid artery stenting is an alternative to carotid endarterectomy in ... Carotid endarterectomy is used to reduce the risk of strokes caused by carotid artery stenosis over time. Carotid stenosis can ... is a surgical procedure used to reduce the risk of stroke from carotid artery stenosis (narrowing the internal carotid artery ... The lumen of the internal carotid artery is opened, and the atheromatous plaque substance removed. The artery is closed using ...
Nathan Horton
... to help Florida win 4-2 in the game after Richard Zedník suffered a neck injury in which he had his external carotid artery cut ... I just tried to get it to the net and it went in every time." Despite missing ten games to injury, Horton was tied with ... Horton has not played in an NHL game since April 2014 due to a back injury. Though he did not officially retire, the surgery ... However, Horton was unavailable for the game due to an injury. The goal scored by Horton in the original fixture was the only ...
Ischemia
... may develop as a result of arterial dissection in the carotid artery or aorta or as a result of iatrogenic arterial injury (e.g ... Reduction of body temperature also reduces the inflammation response and reperfusion injury. For frostbite injuries, limiting ... Surgical revascularization may be used in the setting of trauma (e.g., laceration of the artery). Amputation is reserved for ... Kostandy, Botros B. (2012). "The role of glutamate in neuronal ischemic injury: the role of spark in fire". Neurol Sci. 33 (2 ...
Yulia Drunina
In 1943 Drunina was seriously injured when a shell fragment struck her in the neck several millimeters from her carotid artery ... Unaware of the severity of her injury, she simply wrapped her neck in bandages and continued to work. Eventually, she was ...
Bulletproofing
... narrowly missing his carotid artery. A portion of his silk neckerchief was carried into the wound by the bullet, preventing a ... to protect personnel from death or serious injuries. There are various mandatory tests which items must pass before they can be ... more serious injury, but the scarf was undamaged. The Tombstone Epitaph reported, "A silken armor may be the next invention." ...
Bungee jumping
Very serious injury can also occur if the jumper's neck or body gets entangled in the cord. More recently, carotid artery ... Traumatic carotid artery dissection caused by bungee jumping. J Vascular Surg 2007;46:1044-6 "Bungee jumping suppresses innate ... Whiplash injuries may occur as the jumper is jolted on the bungee cord and in at least one case, this has led to quadriplegia ... All of these injuries have occurred in fit and healthy people in their twenties and thirties. Bungee jumping has also been ...
List of MeSH codes (C14)
... carotid artery diseases MeSH C14.907.253.123.331 - carotid artery thrombosis MeSH C14.907.253.123.345 - carotid artery injuries ... carotid artery injuries MeSH C14.907.253.535.500.300 - carotid artery, internal, dissection MeSH C14.907.253.535.500.350 - ... carotid artery, internal, dissection MeSH C14.907.253.123.360 - carotid stenosis MeSH C14.907.253.123.490 - carotid-cavernous ... carotid artery, internal, dissection MeSH C14.907.253.123.345.400 - carotid-cavernous sinus fistula MeSH C14.907.253.123.353 - ...
Mary Jane Kelly
... and the injury that had caused her death had been the severence of her right carotid artery. This conclusion was supported by a ...
Clint Malarchuk
... known for surviving a life-threatening injury during a 1989 NHL game when Steve Tuttle's skate blade sliced his carotid artery ... As they collided, Tuttle's skate blade hit the right front side of Malarchuk's neck, severing his carotid artery and partially ... Bisson, Leslie J.; Sanders, Samuel M.; Noor, Sonya; Curl, Richard; McCormack, Robert (2009). "Common Carotid Artery Laceration ... lacerating his common carotid artery, causing immediate massive blood loss. Although Malarchuk initially refused to view the ...
Neural tube defect
... blockage in the carotid artery: some researchers think that a blockage of the carotid artery leads to the under-/no development ... Hydranencephaly is a result of an injury of the nervous system or an abnormal development of the nervous system. The neural ... The carotid artery is the most important blood supplier of the brain. With a blockage, the brain barely receives blood. Blood ... The cause of these injuries/development is not clear. Theories regarding the causes of hydrancephaly include: ...
Rick Carelli
He suffered a basilar skull fracture, damaged his carotid artery and sinus. He recovered and returned to race the entire 2000 ... Carelli raced every series race until he suffered near-fatal injuries when his truck hit the wall during a race at Memphis ...
2017 Portland train attack
The attacker severed Micah's left jugular vein, while narrowly missing his carotid artery by one millimetre (0.039 in). ... specifically a knife injury to his throat. ...
Guttural pouch
Odd-toed perrisodactyls such as horses lack a carotid rete, but since the internal carotid artery passes through the guttural ... This anatomical adaptation acts to protect brain tissue from injury due to overheating. ... near the internal carotid artery. Clinical signs include unilateral or bilateral epistaxis due to erosion of the artery walls, ... The external carotid artery passes ventral to the medial compartment before crossing to the lateral wall of the lateral ...
Dutch Schultz
Landau's carotid artery was severed by a bullet passing through his neck, and Rosenkrantz was hit repeatedly at point-blank ... Nevertheless, despite their injuries, both gangsters rose to their feet, returned fire, and drove the assassins out of the ... He eventually died from his injuries 29 hours after the shooting. Schultz was baptized and received the last rites from a ...
2013 La Défense attack
The attacker stabbed the soldier several times, narrowly missing Cordier's jugular vein and carotid artery. The soldier ... He was stabbed in the neck and had lost a considerable amount of blood; however, his injuries were not life-threatening. He was ...
Chiropractic
Chung CL, Côté P, Stern P, L'espérance G (2014). "The Association Between Cervical Spine Manipulation and Carotid Artery ... Ndetan HT, Rupert RL, Bae S, Singh KP (February 2009). "Prevalence of musculoskeletal injuries sustained by students while ... The incidence of internal carotid artery dissection following cervical spine manipulation is unknown.[151] The literature ... There is very low evidence supporting a small association between internal carotid artery dissection and chiropractic neck ...
Parrot
... a different arrangement of the carotid arteries, a gall bladder, differences in the skull bones, and lack the Dyck texture ... causing serious injury.[84] For this reason, parrot rescue groups estimate that most parrots are surrendered and rehomed ...
Intraparenchymal hemorrhage
... of the carotid arteries. These arteries are the large blood vessels in your neck that feed your brain. Transcranial Doppler ( ... reperfusion injury - hemorrhagic transformation - cold exposure - rupture of an aneurysm or arteriovenous malformation (AVM) - ... Carotid duplex: A carotid duplex is an ultrasound study that assesses whether or not you have atherosclerosis (narrowing) ...
Intravenous therapy
Surrounding structures such as the pleura and carotid artery are also at risk of damage with the potential for pneumothorax or ... One reason veins are preferred over arteries for intravascular administration is because the flow will pass through the lungs ... even cannulation of the artery. There are several types of central IV access, depending on the route that the catheter takes ...
Strok bahasa Indonesia, ensiklopedia bebas
Beberapa ahli lain mempertimbangan klasifikasi berdasarkan fenotipe seperti keberadaan internal carotid artery plaque, intima- ... "Neural plasticity after peripheral nerve injury and regeneration". Group of Neuroplasticity and Regeneration, Institute of ... baik yang bersifat intrakranial seperti moderate middle cerebral artery stenosis, ekstrakranial seperti vertebral artery origin ... Sistem TOAST membagi stroke menjadi 5 subtipe yaitu,[11][12] large artery atherosclerosis (LAAS), cardiaoembolic infarct (CEI ...
Common ostrich
... a network of arteries originating from the ophthalmic artery. The ophthalmic rete is analogous to the carotid rete found in ... When threatened, common ostriches run away, but they can cause serious injury and death with kicks from their powerful legs.[33 ... The interatrial artery of the ostrich is small in size and exclusively supplies blood to only part of the left auricle and ... The coronary arteries start in the right and left aortic sinus and provide blood to the heart muscle in a similar fashion to ...
Hypertensive emergency
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Endothelial injury and dysfunction. *Fibrinoid necrosis of the arterioles. *Deposition of platelets and fibrin ... leading to pathologic changes in the small arteries of the kidney. Affected arteries develop endothelial dysfunction and ... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ...
Cadaver
Fluid can be injected into the arterial system (typically through the carotid or femoral arteries), the main body cavities, ... King AI, Viano DC, Mizeres N, States JD (April 1995). "Humanitarian benefits of cadaver research on injury prevention". The ... Erasistratus also discovered and distinguished between many details within the veins and arteries of the human body. Herophilus ... it was approximated that improvements made to cars since cadaver testing have prevented 143,000 injuries and 4250 deaths. ...
Inferior thyroid artery
The ascending cervical artery is a small branch which arises from the inferior thyroid artery as it passes behind the carotid ... This makes it vulnerable to injury during surgery that involves ligating the inferior thyroid artery, such as excision of the ... ACA (anterior communicating, Recurrent artery of Heubner, Orbitofrontal artery). *MCA (anterolateral central, Prefrontal artery ... The inferior thyroid artery is an artery in the neck. It arises from the thyrocervical trunk and passes upward, in front of the ...
Sperm whale
There is no costocervical artery. There is no direct connection between the internal carotid artery and the vessels of the ... If the orca pod is large, its members may sometimes be able to kill adult female sperm whales and can at least injury an entire ... Experimental studies attempting to duplicate this effect have been unable to replicate the supposed injuries, casting doubt on ... The arteries that leave the aortic arch are positioned symmetrically. ...
Hypoxia (medical)
In humans, hypoxia is detected by the peripheral chemoreceptors in the carotid body and aortic body, with the carotid body ... to an extent that parallels the degree to which resting mean pulmonary artery pressure is elevated. Although the severity of ... Electrical injury. *Drowning. *Lightning injuries. Ungrouped skin conditions resulting from physical factors. *Dermatosis ...
Intracerebral hemorrhage
Spinal cord injury. *Anterior spinal artery syndrome. *Brown-Séquard syndrome. *Cauda equina syndrome ... Chapter 5, "Pathology of Brain Damage After Head Injury" Cooper P and Golfinos G. 2000. Head Injury, 4th Ed. Morgan Hill, New ... The risk of death from an intraparenchymal bleed in traumatic brain injury is especially high when the injury occurs in the ... "Overview of Adult Traumatic Brain Injuries." Archived 2008-02-27 at the Wayback Machine Retrieved on 2008-01-16. ...
Trachea
To its sides run the carotid arteries and inferior thyroid arteries; and to its sides on its back surface run the recurrent ... Scarring from tracheobronchial injury or intubation; or inflammation associated with granulomatosis with polyangiitis may also ... To the front left lie the large blood vessels the aortic arch and its branches the left common carotid artery and the ... These arteries join (anastamoses) with ascending branches of the bronchial arteries, which are direct branches from the aorta, ...
Fistula
H05.81) Carotid cavernous fistula. *(H70.1) Mastoid fistula *Craniosinus fistula: between the intracranial space and a ... So many cases have been reported that the destruction of the vagina is considered a war injury and recorded by doctors as a ... Pulmonary arteriovenous fistula: between an artery and vein of the lungs, resulting in shunting of blood. This results in ... Fistulas are usually caused by injury or surgery, but they can also result from an infection or inflammation.[4] Fistulas are ...
Ear
The posterior auricular artery is a direct branch of the external carotid artery, and the anterior auricular arteries are ... Injury. Outer ear. Injuries to the external ear occur fairly frequently, and can leave minor to major deformity. Injuries ... ascending pharyngeal artery, internal carotid artery, and the artery of the pterygoid canal.[8] ... "Ear Injuries" (PDF). Council of Europe.. *^ "Ear Injury - Injuries and Poisoning". Merck Manuals Consumer Version. Retrieved ...
Rat
... left common carotid artery, and left subclavian artery, as well as geometrically similar, nonplanar curvature in the aortic ... Mackenzie, SJ (2015). "Innervation and function of rat tail muscles for modeling cauda equina injury and repair". Muscle and ... Milcheski, Dimas (2012). "Development of an experimental model of degloving injury in rats". Brazilian Journal of Plastic ... as the high density of vascular tissue within the tail becomes exposed upon avulsion or similar injury to the structure. The ...
Pulmonary hypertension
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs.[7] Symptoms ... Only those patients whose mean pulmonary artery pressure falls by more than 10 mm Hg to less than 40 mm Hg with an unchanged or ... It is the surgical removal of an organized thrombus (clot) along with the lining of the pulmonary artery; it is a very ...
Superior thyroid artery
This artery branches from the superior thyroid artery near its bifurcation from the external carotid artery. Together with the ... making it at risk for injury during surgery. ... The superior thyroid artery arises from the external carotid ... The sternocleidomastoid branch runs downward and laterally across the sheath of the common carotid artery, and supplies the ... The infrahyoid branch (or hyoid artery): a small artery that runs along the lower border of the hyoid bone beneath the ...
Pituitary apoplexy
The cavernous sinus also contains the carotid artery, which supplies blood to the brain; occasionally, compression of the ... traumatic brain injury, pregnancy (during which the pituitary enlarges) and treatment with estrogens. Hormonal stimulation ... especially coronary artery bypass graft, where there are significant fluctuations in the blood pressure), disturbances in blood ... but tumors develop a blood supply from the nearby inferior hypophyseal artery that generates a higher blood pressure, possibly ...
Long-term complications of standing
Atherosclerosis can lead to coronary artery disease, carotid artery disease, peripheral artery disease, and aneurysms. Standing ... of all worker injury and illness". Considerable research has been conducted as to the extent of muscle injuries and all have ... The authors also found that men with carotid stenosis or ischemic heart disease were at greater risk for the progression of ... 2000) the authors examined the relationship between standing at work and the progression of carotid atherosclerosis in men. ...
Venous thrombosis
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Trauma[6] and minor leg injury[12]. *Previous VTE[13]. *Oral contraceptives[8][14] ... Bauersachs RM, Lindhoff-Last E, Ehrly AM: [Ambulatory treatment of an acute pulmonary artery embolism in fresh thigh vein ...
Orbit (anatomy)
The ophthalmic artery is a crucial structure in the orbit, as it is often the only source of collateral blood to the brain in ... Injury to any one of these structures by infection, trauma or neoplasm can cause temporary or permanent visual dysfunction, and ... cases of large internal carotid infarcts, as it is a collateral pathway to the circle of Willis. In addition, there is the ... The optic canal contains the optic nerve (cranial nerve II) and the ophthalmic artery, and sits at the junction of the sphenoid ...
Hypertensive heart disease
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... "WHO Disease and injury country estimates". World Health Organization. 2009. Retrieved Nov 11, 2009.. ...
CT scan
Specifically, it looks for calcium deposits in the coronary arteries that can narrow arteries and increase the risk of heart ... or traumatic brain injury are suspected.[23] Even in emergency situations, when a head injury is minor as determined by a ... allowing radiologists to assess the extent of occlusion in the coronary arteries, usually in order to diagnose coronary artery ... This ranges from arteries serving the brain to those bringing blood to the lungs, kidneys, arms and legs. An example of this ...
Cervical vertebrae
This separates the carotid artery from the vertebral artery and the carotid artery can be massaged against this tubercle to ... Injuries to the cervical spine are common at the level of the second cervical vertebrae, but neurological injury is uncommon. ... The carotid tubercle is also used as a landmark for anaesthesia of the brachial plexus and cervical plexus. ... Common patterns of injury include the odontoid fracture and the hangman's fracture, both of which are often treated with ...
ಪಲ್ಮನರಿ ಎಂಬಾಲಿಸಮ್ (ಶ್ವಾಸಕೋಶದ ಧಮನಿಬಂಧ) - ವಿಕಿಪೀಡಿಯ
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Chest spiral CT scan with radiocontrast agent showing multiple filling defects of principal branches of the pulmonary arteries ...
Úsáideoir:EÓMurchadha - Vicipéid
Stenosis of the carotid arteries can presage cerebral infarcts (strokes). DVT in the legs can be found via ultrasound before it ... Extensive hemoperitoneum (bleeding inside the body cavity) or injury to the major organs may require emergent surgical ... Interventional radiologists diagnose and treat several disorders including peripheral vascular disease, renal artery stenosis, ... clots in the arteries of the lungs), aortic dissection (tearing of the aortic wall), appendicitis, diverticulitis, and ...
Thrombosis
Endothelial injury is almost invariably involved in the formation of thrombi in arteries, as high rates of blood flow normally ... The former affects vessels such as the internal carotids, vertebral and the circle of Willis. The latter can affect smaller ... Targeting ischemia/reperfusion injury[edit]. Main article: Reperfusion injury. With reperfusion comes ischemia/reperfusion (IR ... Endothelial cell injury[edit]. Any inflammatory process, such as trauma, surgery or infection, can cause damage to the ...
Thrombosis of Internal Carotid Artery after Soft-palate Injury | The BMJ
Hemidystonia secondary to carotid artery gunshot injury.
The bullet entered through the left anterior neck and severed the left common carotid artery. Emergency surgery was performed ... Carotid Artery Injuries*. Carotid Artery, Common / surgery. Cerebral Infarction / etiology, surgery. Dystonia / etiology*, ... The bullet entered through the left anterior neck and severed the left common carotid artery. Emergency surgery was performed ...
IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. -...
Carotid injury was performed in WT and IL-10 KO mice by wire injury method. (A-B) Mice were injected with Evans blue (0.5%) 2- ... Carotid injury was performed in WT and IL-10 KO mice by wire injury method for 28 days. (A-B) 24h prior to euthanasia, BrdU (30 ... C-D) For morphometric analysis, 28 days after injury carotid artery were isolated and neo-intimal hyperplasia was measured by ... C) ET and H&E staining of carotid artery sections on 28 days post-injury visualized neo-intimal thickening. Representative ...
Carotid Artery Injuries | Harvard Catalyst Profiles | Harvard Catalyst
THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS ... "Carotid Artery Injuries" by people in Harvard Catalyst Profiles by year, and whether "Carotid Artery Injuries" was a major or ... "Carotid Artery Injuries" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Carotid Artery Injuries*Carotid Artery Injuries. *Artery Injuries, Carotid. *Artery Injury, Carotid ...
Carotid Artery Injuries
Summary Report | CureHunter
THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS ... Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; ... and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473) ... Carotid; Injuries, Carotid Artery; Artery Injuries, Carotid; Artery Injury, Carotid; Artery Trauma, Carotid; Carotid ...
CAROTID ARTERY OCCLUSION DUE TO NONPENETRATING INJURY : Journal of Trauma and Acute Care Surgery
Home , May 1967 - Volume 7 - Issue 3 , CAROTID ARTERY OCCLUSION DUE TO NONPENETRATING INJURY ... THE SPECTRUM OF BLUNT INJURY TO THE CAROTID ARTERY: A MULTICENTER PERSPECTIVE ... Blunt Cerebrovascular Injuries: Does Treatment Always Matter? * Blunt cerebrovascular injuries: Redefining screening criteria ... Blunt cerebrovascular injury screening with 64-channel multidetector computed tomography: More slices finally cut it ...
Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury | Circulation
Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury. Hiroyuki Morita ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ... Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury ...
Penetrating carotid artery injuries treated by an urgent endovascular stent technique: report of two cases.
Penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures ... Carotid artery injuries caused by blunt traumaAnn SurgYear: 198019274777406566. 3. Roon AJ,Christensen N. Evaluation and ... Zone II is the most common site of carotid artery injury, where there is often a tendency for the hematoma to be compressed and ... Penetrating Carotid Artery Injuries Treated by an Urgent Endovascular Stent Technique: Report of Two Cases ...
Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid...
... bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in ... RESULTS: Cerebral ACT and BHB levels increased significantly in Group T after 30min of carotid occlusion (time 0). The highest ... CONCLUSIONS: The partial transient acute global brain ischemia induced by the bilateral carotid occlusion in Wistar rats ... ischemia/reperfusion through an experimental model of brain ischemia induced by simple occlusion of common carotid arteries ( ...
Bilateral blunt carotid artery injury: A case report and review of the literature
A 22-year-old man sustained a strangulation-type injury to the neck, with bilateral blunt carotid artery injuries detected on ... Blunt carotid artery injury (BCI) is rare, with a reported incidence of 0.33% in some series.[1] Despite advances in imaging ... We report a case of bilateral internal carotid artery (ICA) injury due to strangulation. At presentation there was no ... 2. Kerby J, May A, Gomez C, Rue L. Treatment of bilateral blunt carotid injury using percutaneous angioplasty and stenting: ...
Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery |...
Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery. ... Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery ...
Enhanced Recovery of Injury-Caused Downregulation of Paxillin Protein by eNOS Gene Expression in Rat Carotid Artery |...
A segment of the common carotid artery 1 cm long was isolated by temporary ligation of the proximal common carotid artery and ... and Erk proteins in injured carotid artery. A, 2 and 5 days after injury; B, 2 weeks after injury. ... Enhanced Recovery of Injury-Caused Downregulation of Paxillin Protein by eNOS Gene Expression in Rat Carotid Artery. Mechanism ... Activation of MAP kinase in vivo follows balloon overstretch injury of porcine coronary and carotid arteries. Circ Res. 1997;81 ...
Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury |...
... was introduced through the left external carotid artery and passed into the common carotid artery. Injury was induced by ... The external carotid artery was ligated, and the wound was closed. Uninjured right carotid arteries were used as controls. At ... Effect of Injury on GAPDH mRNA Expression. Northern analysis of RNA from uninjured and injured rat carotid arteries was used to ... Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury. Karen E. ...
Upregulation of Basement Membrane-Degrading Metalloproteinase Secretion After Balloon Injury of Pig Carotid Arteries |...
... a pig carotid artery model in which both deep medial tears and stretch-induced injury occur was used. Both types of injury are ... In the rat carotid artery, injury increases tissue levels of gelatinase B and activates gelatinase A,13 19 further implicating ... Response to Balloon Injury in the Pig Carotid Artery. As described previously,23 balloon inflation caused dilatation in all ... Sections of a carotid artery harvested 7 days after balloon injury were hybridized with 106 cpm of gelatinase B antisense RNA ( ...
AID 1260415 - Antithrombotic activity in cynomolgus monkey model of electrolytic injury-induced carotid artery thrombosis...
Determination of acute vascular injury and edema in porcine carotid arteries by T2 weighted cardiovascular magnetic resonance |...
Inflammation plays an essential role for destabilization and rupture of carotid atherosclerotic plaques causing embolic ... Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. Four to nine days (average six) post injury ... This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by ... Determination of acute vascular injury and edema in porcine carotid arteries by T2 weighted cardiovascular magnetic resonance. ...
Risk factors for internal carotid artery injury in adults during simple nasopharyngeal surgeries | springermedizin.de
The purpose of this study attempted to analyze the potential risk factors for internal carotid artery injury during simple ... Anatomic variations of carotid arteries were classified, and various distances from the internal carotid arteries to the ... Risk factors for internal carotid artery injury in adults during simple nasopharyngeal surgeries. Zeitschrift:. European ... The purpose of this study attempted to analyze the potential risk factors for internal carotid artery injury during simple ...
Radiation injury involving the internal carotid artery. Report of two cases - Journal of Neurosurgical Sciences 2000 September...
Radiation injury involving the internal carotid artery. Report of two cases - Journal of Neurosurgical Sciences 2000 September; ... Radiation injury involving the internal carotid artery. Report of two cases. Santoro A., Bristot R., Paolini S., Di Stefano D ... Radiation ther-a-py is an uncom-mon -cause of sten-o-sis and occlu-sions of the cer-vi-cal inter-nal carot-id -artery (ICA). We ... Cerebral angio-gra-phy -obtained on admis-sion -showed occlu-sion of the -right ICA and -right sub-cla-vian arter-ies, -both - ...
Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal...
Objective: Internal carotid artery injury (ICAI) is a rare, life-threatening complication of endoscopic endonasal approaches ... Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal ... Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal ... Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal ...
Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits. - Semantic Scholar
CONCLUSIONS Patients who have carotid stents placed for blunt carotid pseudoaneurysms have a 21% complication rate and a ... underwent carotid stent placement. There were 4 complications in patients undergoing carotid stent placement: 3 strokes and 1 ... 8 patients had poststent carotid occlusion despite having received concurrent anticoagulation therapy. Carotid occlusion rates ... HYPOTHESIS Carotid stenting is safe and effective for blunt CAIs. DESIGN Analysis of a prospective database of all patients ...
TRAUMATIC ANEURYSM OF THE INTERNAL CAROTID ARTERY AND RUPTURE OF THE DUODENUM FOLLOWING SEAT BELT INJURY
... Cerebral embolism, ... due to a traumatic aneurysm of the internal carotid artery, and a duodenal tear occurred in a young woman who was wearing a ... ITRD Terms: 2035: Abdomen; 1643: Accident; 2030: Brain; 2163: Injury; 1476: Safety belt; 9084: Use ... The aneurysm was treated by proximal carotid ligation. (Author/TRRL). * Availability: *Find a library where document is ...
Signa Vitae » Internal carotid artery dissection at the supraclinoid portion after severe traumatic head injury in a child »...
Internal carotid artery dissection at the supraclinoid portion after severe traumatic head injury in a child Posted By Junya ... Endovascular repair of traumatic cervical internal carotid artery injuries: a safe and effective treatment option. AJNR Am J ... Anterior cerebral artery, anterior choroidal artery and posterior communication artery are detected. ... www.signavitae.com/2013/10/internal-carotid-artery-dissection-at-the-supraclinoid-portion-after-severe-traumatic-head-injury-in ...
Cureus | Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery
... arterial bleeding was encountered near the right internal carotid artery (ICA). Durable hemostasis could not be achieved with ... Arterial injuries, although serious, are not always catastrophic. Critical steps are immediate recognition of bleeding, ... Given the presence of good collateral flow through the anterior and posterior communicating arteries, the right ICA was ... Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa ...
Carotid artery injuries | definition of Carotid artery injuries by Medical dictionary
What is Carotid artery injuries? Meaning of Carotid artery injuries medical term. What does Carotid artery injuries mean? ... Looking for online definition of Carotid artery injuries in the Medical Dictionary? Carotid artery injuries explanation free. ... common carotid artery. (redirected from Carotid artery injuries). Also found in: Dictionary, Thesaurus, Encyclopedia. com·mon ... Carotid artery injuries , definition of Carotid artery injuries by Medical dictionary https://medical-dictionary. ...
Primary Repair vs Ligation for Carotid Artery Injuries<...
"Primary Repair vs Ligation for Carotid Artery Injuries",. abstract = "The morbidity and mortality of carotid arterial injuries ... Ledgerwood, A. M., Mullins, R., & Lucas, C. E. (1980). Primary Repair vs Ligation for Carotid Artery Injuries. Archives of ... Ledgerwood, AM, Mullins, R & Lucas, CE 1980, Primary Repair vs Ligation for Carotid Artery Injuries, Archives of Surgery, vol ... Ledgerwood, Anna M. ; Mullins, Richard ; Lucas, Charles E. / Primary Repair vs Ligation for Carotid Artery Injuries. In: ...
2020 ICD-10-CM Diagnosis Code S15.001: Unspecified injury of right carotid artery
Injury of carotid artery of neck. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Applicable To*Injury of carotid ... Unspecified injury of right carotid artery. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code *S15.001 should not be used ... Injury of blood vessels at neck level. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Code Also*any associated open ... Injury, poisoning and certain other consequences of external causes. Note*Use secondary code(s) from Chapter 20, External ...
2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent | Journal of Cardiovascular...
A carotid artery injury model was performed in 8 wild-type and 8 CRP2-deficient (CRP2-/-) mice; the right carotid artery wall ... 2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent. ... of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury ... SNR and CNR of the injured right compared to the non injured left carotid artery was significantly increased (p , 0.001) both ...
2017/18 ICD-10-CM Diagnosis Code S15.001S: Unspecified injury of right carotid artery, sequela
Injury of carotid artery of neck. 2016 2017 2018 Non-Billable/Non-Specific Code Applicable To*Injury of carotid artery (common ... Unspecified injury of right carotid artery, sequela. 2016 2017 2018 Billable/Specific Code POA Exempt *S15.001S is a billable/ ... Injury of blood vessels at neck level. 2016 2017 2018 Non-Billable/Non-Specific Code Code Also*any associated open wound (S11.- ... Injury, poisoning and certain other consequences of external causes. Note*Use secondary code(s) from Chapter 20, External ...
Stanford Endoscopic Endonasal Skull Base Surgery: Hands-On Course Registration, Thu, Aug 15, 2019 at 1:00 PM | Eventbrite
Carotid Artery Injury After Endonasal Surgery<...
title = "Carotid Artery Injury After Endonasal Surgery",. abstract = "Carotid artery injury during endonasal surgery is the ... Carotid artery injury during endonasal surgery is the most feared and catastrophic complication. Internal carotid artery injury ... Carotid Artery Injury After Endonasal Surgery. Together they form a unique fingerprint. * Carotid Artery Injuries Medicine & ... Carotid artery injury during endonasal surgery is the most feared and catastrophic complication. Internal carotid artery injury ...
DISSECTIONOcclusionBifurcationStenosisBalloon injuryStentThrombosisPseudoaneurysmTraumatic carotid arteryVascular injuryAngiographyCervicalAneurysmWire-Injured Carotid ArteryAngioplastyInvolving the internal carotiEndovascularTraumaWoundsSurgeryStrokeNeointimalDenudationNeointimaEndarterectomyMouse model of carotidRevascularizationLeft commonCerebrovascular injuriesDissectionsHyperplasiaPatients with carotidAbstractBlunt carotid arterialMurine carotidIntracranial portionEndothelialProximalPosteriorRight internal carotid1994Arterial injuryMorbidity and mortaSevereLigationCoronary arteryCommon carotidExternal carotidStentsNECK INJURIES
DISSECTION41
- An emergency craniotomy was performed, and traumatic carotid artery (CA) dissection (tCAD) was revealed by cerebral angiography. (signavitae.com)
- Angiography of the right ICA showed the pearl and string sign at the supraclinoid portion of the ICA, and traumatic carotid artery (CA) dissection (tCAD) was suspected. (signavitae.com)
- Vascular aspects: aneurysmal dissection of the right internal carotid in its subpetrous portion, additional image on left lateral face of the left internal carotid in its intracavernous portion, strongly suggestive of posttraumatic pseudoaneurysm (contact fracture of carotid canal). (imaios.com)
- The outcome was favourable despite the severe carotid lesions presenting with occlusion secondary to dissection. (jccm.ro)
- This report describes recently treated patients with carotid artery dissection caused by blunt softball injuries, as well as the results of a study of carotid artery trauma in a community. (elsevier.com)
- Data obtained through the medical records linkage system used for epidemiologic studies in Olmsted County, MN were used to identify all cases of traumatic internal carotid artery dissection diagnosed from 1987 through 1994. (elsevier.com)
- In two patients (50%) the carotid dissection was a result of the direct impact of a softball. (elsevier.com)
- T raumatic carotid artery dissection is a diagnosis that has received significant discussion in the neurosurgical and trauma literature. (thejns.org)
- 13 Appropriate early diagnosis and treatment of traumatic carotid artery dissection require a high index of suspicion to optimize outcome. (thejns.org)
- If a diagnosis of spontaneous internal carotid artery dissection is under consideration, laboratory studies are largely irrelevant for diagnostic purposes. (medscape.com)
- Magnetic resonance angiography (MRA) may have already replaced conventional angiography for the diagnosis of internal carotid artery dissection. (medscape.com)
- Some institutions use it as the first and only imaging modality when carotid artery dissection is suspected. (medscape.com)
- [ 15 ] and mural expansion, thus confirming the diagnosis of carotid artery dissection. (medscape.com)
- MRA may fail to detect intramural hematoma within the first 24-48 hours after the occurrence of carotid artery dissection. (medscape.com)
- Helical (spiral) CT angiography (CTA) has an established role in the diagnosis of internal carotid artery dissection, and with the increased use and availability of high-resolution multidetector scanners, it is rapidly replacing conventional angiography and possibly MRA as the diagnostic modality of choice. (medscape.com)
- CTA may be the first (or even the only) modality used for screening and diagnosis in trauma patients who fit general screening criteria (based on signs, symptoms, and mechanism) for carotid artery dissection and who will already be undergoing CT for another indication. (medscape.com)
- When obtaining a CTA of the neck, the physician must specifically request for the study to rule out internal carotid artery dissection. (medscape.com)
- On noncontrast CT, dissection of the internal carotid artery may be inferred from indirect findings, which include soft-tissue swelling, hematoma adjacent to the internal carotid artery, and infiltration of perivascular fat planes. (medscape.com)
- Noncontrast CT is not an adequate screening or diagnostic test for internal carotid artery dissection. (medscape.com)
- Conventional angiography was the standard modality for diagnosing internal carotid artery dissection. (medscape.com)
- Styloid process length and styloid/hyoid bone proximity to the internal carotid artery (ICA) have been implicated in certain carotid pathologies (e.g. carotid artery dissection). (bioportfolio.com)
- Vascular aspects: dissection of the subpetrous portion of both internal carotids (left aneurysmal dissection). (imaios.com)
- Few population based analyses exist for blunt trauma to the carotid artery resulting in dissection. (dcorthoacademy.org)
- Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related? (jamanetwork.com)
- Vertebral artery dissection ( VAD ) is a flap-like tear of the inner lining of the vertebral artery , which is located in the neck and supplies blood to the brain . (wikipedia.org)
- The symptoms of vertebral artery dissection include head and neck pain and intermittent or permanent stroke symptoms such as difficulty speaking , impaired coordination and visual loss . (wikipedia.org)
- Vertebral dissection may occur after physical trauma to the neck, such as a blunt injury (e.g. traffic collision ), strangulation or chiropractic manipulation , but may also happen spontaneously. (wikipedia.org)
- Vertebral artery dissection is less common than carotid artery dissection (dissection of the large arteries in the front of the neck). (wikipedia.org)
- Vertebral artery dissection is one of the two types of dissection of the arteries in the neck. (wikipedia.org)
- The other type, carotid artery dissection, involves the carotid arteries . (wikipedia.org)
- Vertebral artery dissection is further classified as being either traumatic (caused by mechanical trauma to the neck) or spontaneous, and it may also be classified by the part of the artery involved: extracranial (the part outside the skull) and intracranial (the part inside the skull). (wikipedia.org)
- Head pain occurs in 50-75% of all cases of vertebral artery dissection. (wikipedia.org)
- [2] 8% of all cases of vertebral and carotid dissection are diagnosed on the basis of pain alone. (wikipedia.org)
- If the dissection of the artery extends to the part of the artery that lies inside the skull, subarachnoid hemorrhage may occur (1% of cases). (wikipedia.org)
- 13-16% of all people with vertebral or carotid dissection have dissection in another cervical artery. (wikipedia.org)
- It is therefore possible for the symptoms to occur on both sides, or for symptoms of carotid artery dissection to occur at the same time as those of vertebral artery dissection. (wikipedia.org)
- The causes of vertebral artery dissection can be grouped under two main categories, spontaneous and traumatic. (wikipedia.org)
- Dissection, Carotid Artery - Cervical artery dissection is a significant cause of stroke in patients under 40 years of age. (searchbeat.com)
- A vertical neck incision along the anterior border of the SCM muscle dissection through skin, subcutaneous tissue, and platysma, posterolateral retraction of the SCM opening the carotid sheath. (brainscape.com)
- The diagnosis and management of penetrating cerebrovascular injury and spontaneous cerebrovascular dissection are reviewed elsewhere. (uptodate.com)
- See 'Penetrating neck injuries: Initial evaluation and management' and 'Spontaneous cerebral and cervical artery dissection: Clinical features and diagnosis' . (uptodate.com)
Occlusion12
- PURPOSE: To evaluate the in vivo alterations on ketone bodies metabolism after cerebral ischemia/reperfusion through an experimental model of brain ischemia induced by simple occlusion of common carotid arteries (CCAs) in Wistar rats. (scielo.br)
- Cerebral ACT and BHB levels increased significantly in Group T after 30min of carotid occlusion (time 0). (scielo.br)
- The partial transient acute global brain ischemia induced by the bilateral carotid occlusion in Wistar rats triggered ketogenesis probably due to a central stimulation of catecholamine secretion. (scielo.br)
- A CT angiogram of the neck vessels ( Fig. 1 ) showed total occlusion of the right ICA (grade IV injury) and a filling defect of the left ICA suggestive of an intimal flap (grade II injury). (scielo.org.za)
- CAD, which can lead to thrombosis and occlusion of the anterior, middle cerebral artery or CA, is one of the major causes of ischemic stroke in children. (signavitae.com)
- Preferred techniques for the management of arterial injury during endoscopic surgery are a topic of debate and include direct cautery, clip ligation, tamponade with muscle or hemostatic agent, and endovascular treatments including occlusion, coiling, or stenting [1-5, 7-9] . (cureus.com)
- A combination of bivalirudin (hirulog) plus a novel PAR4 pepducin antagonist, P4pal-i1, effectively inhibited aggregation of human platelets to even high concentrations of thrombin and prevented occlusion of carotid arteries in guinea pigs. (ahajournals.org)
- Likewise, combined inhibition of PAR1 and PAR4 with small-molecule antagonists and pepducins was effective against carotid artery occlusion. (ahajournals.org)
- T he role of adjustable clamps for carotid artery occlusion in the treatment of intracranial aneurysms and cavernous sinus fistulas has decreased during the last two decades with the development of improved microvascular techniques and the advent of interventional radiology. (thejns.org)
- However, in the past, many patients have been treated with various types of clamps (Poppen-Blalock, Selverstone, Crutchfield), some of whom have not been adequately monitored to ensure that the aneurysm has been completely obliterated following carotid artery occlusion. (thejns.org)
- Internal carotid artery agenesis is an uncommon congenital anomaly and it could be misdiagnosed as stenosis/occlusion of this artery. (bioportfolio.com)
- He did well until 2006 when he was found to have a right internal carotid artery near total occlusion, most probably post radiation in origin, with a 40% contralateral stenosis. (hindawi.com)
Bifurcation9
- 250 ms. Signal-to-noise and contrast-to-noise-ratio (SNR, CNR) of the injured vessel wall was determined by manual segmentation of the visually apparent signal of the contrast agent below the carotid bifurcation. (biomedcentral.com)
- Both patients had a low carotid bifurcation. (elsevier.com)
- A low carotid bifurcation may be a risk factor for such injuries. (elsevier.com)
- T he common carotid artery bifurcation usually lies at the level of the C-4 vertebra or the upper border of the thyroid cartilage, 2 but it may occur as low as the level of the T-3 vertebra 8 or as high as the hyoid bone. (thejns.org)
- It is extremely rare that the common carotid artery ascends in the neck without undergoing bifurcation. (thejns.org)
- Using duplex ultrasound, a low invasive examination, information is obtained on the abdominal aortic diameter and the degree of stenosis of the carotid bifurcation. (bioportfolio.com)
- Comparison of two methods for revascularization of the bifurcation of common carotid artery: carotid endarterectomy with longitudinal incision carotid endarterectomy patch angioplasty comp. (bioportfolio.com)
- We report an unusual case of subarachnoid hemorrhage (SAH) caused by rupturing of the traumatic pseudoaneurysm of the internal carotid artery (ICA) bifurcation that resulted from a non-penetrating injury . (bvsalud.org)
- (b) An 0.014″ guidewire is next inserted via the external carotid (EC) artery and traversed along the entire length of common carotid artery up to the carotid bifurcation for 1 minute (distal to head) to induce injury to the vessel. (nih.gov)
Stenosis21
- Indeed, the stenosis of the internal carotid artery can lead to ophthalmological charts. (clinicaltrials.gov)
- The OCT-angiography technique accurately studies the retinal vasculature and also assesses the risk of retinal and choroidal embolism, which is recognized as increased in cases of symptomatic or asymptomatic carotid stenosis. (clinicaltrials.gov)
- The stenosis of the internal carotid artery is a frequent and potentially serious pathology (TIA, ischemic stroke, death), which can also be manifested by ophthalmological charts, foremost among which are transient monocular blindness. (clinicaltrials.gov)
- Prevalence of Carotid Artery Stenosis and Abdominal Aortic Aneurysms in Brussels: a Population-based Screening Study. (bioportfolio.com)
- Both abdominal aortic aneurysm (AAA) and carotid artery stenosis (CAS) are frequent clinical entities, with major morbidity and mortality. (bioportfolio.com)
- A population-based screening study to determine the prevalence of carotid artery stenosis (CAS) and abdominal aortic aneurysms (AAA) in the Brussels Capital Region. (bioportfolio.com)
- Examination is done by one-time duplex ultrasound to perform a diameter measurement of the abdominal aorta and determine the degree of stenosis of the carotid arteries. (bioportfolio.com)
- The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared. (bioportfolio.com)
- The correlation between metabolic syndrome and carotid artery stenosis is well established. (bioportfolio.com)
- The purpose of this study is to determine if carotid artery stenosis can be detected using an electronic stethoscope. (bioportfolio.com)
- External carotid artery (ECA) stenosis is an independent mortality predictor. (bioportfolio.com)
- Carotid Duplex Velocity Criteria Recommended by the Society of Radiologists in Ultrasound and Endorsed by the Intersocietal Accreditation Commission Lacks Predictive Ability for Identifying High Grade Carotid Artery Stenosis. (bioportfolio.com)
- Carotid duplex is the first line imaging modality for characterizing degree of carotid stenosis. (bioportfolio.com)
- However, isolated morphological changes without significant carotid stenosis is rarely symptomatic. (bioportfolio.com)
- Skin temperature maps as a measure of carotid artery stenosis. (bioportfolio.com)
- We analyzed the results of internal carotid artery (ICA) stenosis treatment at our institution according to the treatment modality-carotid endarterectomy (CEA) vs. carotid artery stenting (CAS). (bioportfolio.com)
- The aim of the study is to confirm, whether the MER® stent can be used, without limitations, for the endovascular carotid stenosis treatment in daily clinical practice. (bioportfolio.com)
- Carotid revascularization procedures are performed for more than 87% of cases in patients with asymptomatic internal carotid stenosis (ICS), who are assumed to have a life expectancy of at. (bioportfolio.com)
- Frequency and management of recurrent stenosis after carotid artery stent implantation. (naver.com)
- Compared with sham-injury groups, an ∼50% reduction in arterial stenosis was observed with targeted NP treatment. (pnas.org)
- Screening for Asymptomatic Carotid Artery Stenosis - Lots of data supporting the recommendation that high risk patients be screened for Carotid Artery Disease. (searchbeat.com)
Balloon injury18
- Methods and Results -We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the common carotid artery was assessed. (ahajournals.org)
- Smooth muscle cells have been shown to express mRNA for urokinase plasminogen activator and tissue-type plasminogen activator after balloon injury in the rat model of angioplasty. (ahajournals.org)
- This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by cardiovascular magnetic resonance (CMR) using a T2-weighted short-tau inversion recovery sequence (T2-STIR). (springer.com)
- Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. (springer.com)
- We examined the effect of bortezomib on neointima formation after of a rat carotid artery balloon injury. (bvsalud.org)
- The systemic treatment group exhibited a 29% reduction in neointima volume at two weeks after the balloon injury. (bvsalud.org)
- The whole rat genome microarray expression profiling of carotid artery specimen was emplyed to identify the gene expression profile before and after balloon injury. (datamed.org)
- In our study, the neointimal formation of carotid arteries was apparent at day 7 and markedly increased at day 21 after balloon injury. (datamed.org)
- Expression of four genes (TLR4, IRAK1, IκBα, IL-1β) from TLR signaling pathway was quantified in the same RNA samples by quantitative real-time PCR, conforming that TLR signaling pathway participated in neointimal formation of carotid arteries after balloon injury. (datamed.org)
- Balloon injury-induced gene expression in wistar rat was measured at day 7 and day 21 after balloon injury as compared with uninjured arteries. (datamed.org)
- Basement membrane-degrading metalloproteinases (gelatinases) appear necessary for vascular smooth muscle cell migration and proliferation in culture and for intimal migration of cells after balloon injury to the rat carotid artery. (ox.ac.uk)
- We investigated in the present study the secretion of gelatinases from pig carotid artery tissue after balloon injury. (ox.ac.uk)
- Release of both gelatinase activities was increased at 3 and 7 days relative to segments from uninjured arteries but declined again by 21 days after balloon injury. (ox.ac.uk)
- Consistent with the protein secretion data, in situ hybridization demonstrated that the mRNAs for both gelatinases were upregulated after balloon injury. (ox.ac.uk)
- We conclude that increased gelatinase production occurs in response to balloon injury and may play a role in permitting migration and proliferation of vascular smooth muscle cells. (ox.ac.uk)
- Actinomycin D has been regarded as a potential candidate to prevent balloon injury-induced neointimal formation. (elsevier.com)
- Here, we examined the effects of Exisulind on neointimal formation after balloon injury and its mechanisms of action in VSMCs, endothelial cells, and platelets. (nature.com)
- The glucose transporter isoform, GLUT1, was significantly increased in the neointima after balloon injury. (diabetesjournals.org)
Stent14
- Penetrating carotid artery injuries treated by an urgent endovascular stent technique: report of two cases. (biomedsearch.com)
- Here we report on the endovascular stent techniques used in two cases to address penetrating carotid artery injuries and review the literature. (biomedsearch.com)
- We successfully treated patients who had externally penetrating injuries in neck zone II and were confirmed to have the concurrent presence of large vessel injuries in neck zones I and III by inserting an endovascular stent in an urgent interventional angiography procedure. (biomedsearch.com)
- Covered stent exclusion of blunt traumatic carotid artery pseudoaneurysm: case report and review of the literature. (semanticscholar.org)
- During biopsy of his oropharyngeal lesion, a specimen of tissue was retrieved, with the carotid stent within. (hindawi.com)
- There is no case reported whereby an internal carotid artery endovascular stent was removed accidentally during a lateral pharyngeal mass biopsy, and without bleeding. (hindawi.com)
- Preoperative Computed Tomography scanning (CT) showed the irregular ulcer at the right oropharyngeal space, with the right carotid artery stent completely occluded with no distal perfusion (Figure 1 ), and it was encased in the mass of necrotic tissue. (hindawi.com)
- On inspection, the carotid endovascular stent was identified, invaded, and surrounded by the mass of necrosis that was filling the lateral oropharyngeal wall (Figure 3 ). (hindawi.com)
- Contrast Enhanced computed tomography scan of the neck showing the right carotid stent occluded with no blood flow in the lumen. (hindawi.com)
- Determinants of in-stent restenosis after carotid angioplasty: a case-control study. (naver.com)
- No patients with BCI had open repair, 4.24% had a carotid artery stent (CAS), and 95.76% of patients had no operative intervention. (dcorthoacademy.org)
- Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of Fn-EDA in the vicinity of SMC-rich neointima and peri-strut areas. (jci.org)
- After vascular injury by balloon angioplasty or stent implantation, diverse mechanisms are activated, leading to neointimal hyperplasia. (nature.com)
- Coronary Artery Angioplasty with Stent Coronary artery angioplasty with stent facts, including who needs it. (vitals.com)
Thrombosis1
- In particular, mechanical injury from the procedure results in extensive endothelial denudation, exposing the underlying collagen IV-rich basal lamina, which promotes both intravascular thrombosis and smooth muscle proliferation. (pnas.org)
Pseudoaneurysm5
- Endovascular Trapping of Large Cervical Carotid Pseudoaneurysm in Marfan Syndrome Presenting with Progressive Respiratory Distress. (harvard.edu)
- BACKGROUND Carotid stenting has been advocated in patients with grade III blunt carotid artery injuries (hereafter referred to as 'blunt CAIs') because of the persistence of the pseudoaneurysm and concern for subsequent embolization or rupture. (semanticscholar.org)
- Hemomediastinum with probably posttraumatic dissecting pseudoaneurysm of the right branch of the pulmonary artery, with no active bleeding. (imaios.com)
- In a patient with severe headache and SAH in the right sylvian cistern , which developed within 7 days after a blunt-force head injury , a trans-femoral cerebral angiogram (TFCA) showed aneurysmal sac which was insufficient to confirm the pseudoaneurysm . (bvsalud.org)
- We suggest that in the patient with a history of blunt head injury with SAH following shortly, multi-slab image of 3D TOF MRA can give visualization of the presence of a pseudoaneurysm . (bvsalud.org)
Traumatic carotid artery1
- The diagnosis of traumatic carotid artery injury (TCAI) was based on duplex ultrasound and angio CT scans. (jccm.ro)
Vascular injury20
- Inflammatory cells are likely contributors in the host response to vascular injury, via cytokines and chemokines secretion, including TNF-alpha (TNF). (nih.gov)
- Vascular injury and ReEndo was examined on day 7 by Evans blue perfusion method. (nih.gov)
- A penetrating trauma occurring in the neck can cause severe complications such as hemorrhage as the result of vascular injury, spinal cord injury, respiratory obstruction, and sepsis from esophageal injury. (biomedsearch.com)
- Vinculin, a paxillin-binding protein, was not altered by vascular injury or by eNOS gene transfer. (ahajournals.org)
- Blunt vertebral vascular injury in trauma patients: ATLS® recommendations and review of current evidence. (semanticscholar.org)
- In certain cases, the endoscopic approach can preclude obtaining proximal control of the offending vascular injury and due to anatomic and technical constraints. (cureus.com)
- Smooth muscle cell proliferation and extracellular matrix (ECM) synthesis/turnover are thought to play an important role in vessel wall repair after vascular injury. (biomedcentral.com)
- Preliminary evaluation of the carotid wall thickening seem to confirm our MRI findings and suggests that targeted deletion of CRP2 in mice might lead to a reduced vessel wall thickening and thus to a reduced restenosis after vascular injury. (biomedcentral.com)
- In this study, we demonstrate the successful use of molecular MRI for the non-invasive assessment of alterations in the vessel wall after vascular injury in a mouse model of impaired smooth muscle cell proliferation and ECM formation. (biomedcentral.com)
- 1 Hence, 1 of the aims of the present study was to test the hypothesis that 2-ME can inhibit vascular injury-induced neointima formation. (ahajournals.org)
- Background and Objectives: Clodronate liposomes deplete phagocytic cells, thereby suppressing inflammation after vascular injury. (elsevier.com)
- Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. (jci.org)
- No differences were detected between the tissue-specific cGKI mutants and control mice at different time points after vascular injury on a normolipidemic or apoE-deficient background. (nih.gov)
- Exisulind significantly reduced VSMCs viability, cell cycle progression, migration, and neointimal hyperplasia after vascular injury in rat carotid arteries. (nature.com)
- Re-endothelialization was quantified in Evans blue-stained carotid arteries at 3 and 7 days after vascular injury. (nature.com)
- The abnormal immune response driven by SLE enhances vascular injury mechanism and weaken repair mechanism, breaking vascular dynamic balance which determines the occurrence of CVD ( Figure 1 ). (frontiersin.org)
- This brand-new volume in the best-selling 'Case Review' series uses more than 200 case studies to challenge your knowledge of a full range of topics in emergency radiology, including MDCT-A of vascular injury, CT and MR of spinal injuries, CT and MRI of CNS emergencies, and subtle and classic CT signs of bowel emergencies. (indigo.ca)
- Vascular injury should be suspected in patients with hard signs and evaluated further in patients with soft signs. (springer.com)
- A prospective study for the detection of vascular injury in adult and pediatric patients with cervicothoracic seat belt signs. (springer.com)
- 2. Can duplex ultrasonography (US) or CT angiography rule out an arterial injury in patients with no hard signs of vascular injury on physical examination, thereby making arteriography unnecessary? (east.org)
Angiography6
- Accordingly, unlike the situation in zone II of the neck, where the proximal and distal control of blood vessels can be easily achieved, angiography should be performed in cases of penetrating injury occurring in zones I and III. (biomedsearch.com)
- A 22-year-old man sustained a strangulation-type injury to the neck, with bilateral blunt carotid artery injuries detected on computed tomography (CT) angiography. (scielo.org.za)
- [4] Grade I and II injuries are of particular concern and require follow-up angiography owing to the risk of pseudo-aneurysm formation despite heparin therapy. (scielo.org.za)
- After finishing the craniotomy, the patient was immediately transferred to the angiography suite and cerebral angiography was performed in order to evaluate the condition of intracranial internal carotid artery (ICA). (signavitae.com)
- Imagistic findings (magnetic resonance imaging of the brain, and cervical spine, and magnetic resonance angiography of the head and neck) indicated a very rare condition: left internal carotid artery agenesis accompanied by the absence of the pre-communicant part of the left anterior cerebral artery and of the right posterior communicating artery. (bioportfolio.com)
- He underwent consequently a right carotid artery angiography and endovascular stenting, and was started on anticoagulation. (hindawi.com)
Cervical9
- In addition, fracture or fracture-dislocation of the cervical bones should raise the index of suspicion for internal carotid artery injury. (medscape.com)
- Associated injuries included long bone fractures (28.5%), stroke and intracranial hemorrhage (28.5%), cranial injuries (25.6%), thoracic injuries (23.6%), cervical fractures (21.8%), facial fractures (19.9%), skull fractures (18.8%), pelvic fractures (18.5%), hepatic (13.3%) and splenic (9.2%) injuries. (dcorthoacademy.org)
- Age, injury, poor posture or diseases such as arthritis can lead to degeneration of the bones or joints of the cervical spine, causing disc herniation or bone spurs to form. (aans.org)
- This paper presents cases from the medical literature and popular press in which medical authors have incorrectly reported the facts regarding manipulation injuries of the cervical spine. (chiro.org)
- Injuries to the cervical spine should be assumed in all trauma patients until CT imaging of bony structures is obtained. (springer.com)
- Institutional guidelines should be developed to maintain a consistent approach to the timing of cervical collar removal and when MRI is necessary to evaluate for ligamentous injury. (springer.com)
- Cervical pharyngoesophageal and laryngotracheal injuries. (springer.com)
- The cervical spine provides musculoskeletal stability and supports for the cranium, and a flexible and protective column for movement, balance adaptation, and housing of the spinal cord and vertebral artery. (chiro.org)
- Because of its great mobility and relatively small structures, the cervical spine is the most frequent site of severe spinal nerve injury and subluxations. (chiro.org)
Aneurysm3
- Cerebral embolism, due to a traumatic aneurysm of the internal carotid artery, and a duodenal tear occurred in a young woman who was wearing a seat belt at the time of a motor car accident. (trb.org)
- The aneurysm was treated by proximal carotid ligation. (trb.org)
- Carotid Endarterectomy for Aneurysm - Step by Step - Step by step photos of a carotid aneurysm repair, a rather unusual surgery, provided by PVSS. (searchbeat.com)
Wire-Injured Carotid Artery2
- Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice. (harvard.edu)
- b ) Day 3 wire-injured carotid artery (A and B - 20 x). (c) Day 14 control carotid artery. (nih.gov)
Angioplasty4
- Abstract The temporal relationship of matrix metalloproteinases (MMPs) and a specific tissue inhibitor (TIMP-1) has been examined by reverse transcription-polymerase chain reaction and substrate zymography, after balloon catheter angioplasty of the rat carotid artery. (ahajournals.org)
- The role of carotid angioplasty and stenting in carotid revascularization. (naver.com)
- Thrombin and its receptor play an important role in the formation of neointima after the injury , which provides a potential clue in developing a new approach for prevention and treatment of restenosis after angioplasty . (bvsalud.org)
- 4. The method of claim 3, wherein said vascular interventional procedure is selected from the group consisting of angioplasty, coronary artery surgery and coronary artery stents. (google.com)
Involving the internal caroti1
- Radiation injury involving the internal carotid artery. (minervamedica.it)
Endovascular5
- Endovascular stenting for the treatment of traumatic internal carotid injuries: expanding experience. (semanticscholar.org)
- His history is pertinent for a right internal carotid endovascular stenting 2 years prior to presentation. (hindawi.com)
- High-resolution optical mapping of inflammatory macrophages following endovascular arterial injury. (nih.gov)
- Here we utilize intravital microscopy (IVM) and a dextran-coated nanosensor to spatially map inflammatory macrophages in vivo following endovascular injury of murine carotid arteries. (nih.gov)
- C57Bl/6 mice (n = 23) underwent endovascular guidewire carotid arterial injury. (nih.gov)
Trauma12
- Hundersmarck D, Reinders Folmer E, de Borst GJ, Leenen LPH, Vriens PWHE, Hietbrink F. Penetrating Neck Injury in Two Dutch Level 1 Trauma Centres: the Non-Existent Problem. (harvard.edu)
- Time to stroke: A Western Trauma Association multicenter study of blunt cerebrovascular injuries. (harvard.edu)
- Associated injuries in blunt solid organ trauma: implications for missed injury in nonoperative management. (semanticscholar.org)
- After receiving initial trauma resuscitation, head computed tomography (CT) showed severe traumatic brain injury (TBI) and cranial fractures (figure 1). (signavitae.com)
- Introduction: Lesions of the carotid and vertebral arteries secondary to direct trauma, called blunt cerebrovascular injuries (BCVI) are relatively rare and are markedly different from spontaneous dissections. (jccm.ro)
- In this series of 17 patients with blunt trauma of the carotid, 3 had no symptoms, 10 patients had limb paresis and 4 had severe neurologic deficits. (elsevier.com)
- There are few population based analyses evaluating carotid injury associated with blunt trauma and their associated injuries as well as outcomes. (dcorthoacademy.org)
- The purpose of the study was to investigate the rare condition of blunt carotid arterial injury (BCI) associated with blunt trauma with MVC using a population based approach considering the associated injuries and outcomes. (dcorthoacademy.org)
- These images are a random sampling from a Bing search on the term "Vertebral Artery Injury in Blunt Neck Trauma. (fpnotebook.com)
- A tertiary examination is essential to help ensure that initially missed, incompletely evaluated, or inapparent injuries are identified and managed.Up to 4% of patients will have missed injuries at Level I trauma centers. (clinicaladvisor.com)
- Blunt-Trauma Carotid Artery Injury - Descriptions of traumatic injuries to the Carotid Artery. (searchbeat.com)
- Blunt cerebrovascular injury practice management guidelines: the Eastern Association for the Surgery of Trauma. (springer.com)
Wounds4
- Wounds are injuries that break the skin or other body tissues. (icdlist.com)
- Furthermore, seemingly innocuous wounds may not manifest clear signs or symptoms, and potentially lethal injuries could be easily overlooked or discounted. (medscape.com)
- From the time when Ambroise Pare successfully treated a neck injury in 1552, debate has continued about the best approach for particular neck wounds. (medscape.com)
- For gunshot wounds, approximately 50% (higher with high velocity weapons) of victims have significant injuries, whereas this risk may be only 10% to 20% with stab wounds. (east.org)
Surgery14
- Zurück zum Zitat Solares CA, Ong YK, Carrau RL, Fernandez-Miranda J, Prevedello DM, Snyderman CH, Kassam AB (2010) Prevention and management of vascular injuries in endoscopic surgery of the sinonasal tract and skull base. (springermedizin.de)
- Zurück zum Zitat Weidenbecher M, Huk WJ, Iro H (2005) Internal carotid artery injury during functional endoscopic sinus surgery and its management. (springermedizin.de)
- Zurück zum Zitat Koitschev A, Simon C, Lowenheim H, Naeqele T, Ernemann U (2006) Management and outcome after internal carotid artery laceration during surgery of the paranasal sinuses. (springermedizin.de)
- Arterial injuries are the most feared complication of endoscopic skull base surgery. (cureus.com)
- Carotid artery injury during endonasal surgery is the most feared and catastrophic complication. (edu.au)
- Internal carotid artery injury is more frequent during skull base surgery, and risk factors include acromegaly, previous revision surgery, and prior radiotherapy and bromocriptine therapy. (edu.au)
- The mortality rate for the series was 23%, but only 14% in the patients who had carotid surgery. (elsevier.com)
- Prevedello, Daniel M. / Training model for control of an internal carotid artery injury during transsphenoidal surgery . (fujita-hu.ac.jp)
- Also, it has a special importance in case of planning carotid or trans-sphenoidal hypophyseal surgery. (bioportfolio.com)
- They most often result from accidental neck injuries, or from intraoperative insults in the context of oropharyngeal surgery, mostly tonsillectomy [ 1 ]. (hindawi.com)
- Rowan NR , Turner MT, Valappil B, Fernandez-Miranda J, Wang EW, Gardner PA, Snyderman CH. Injury of the carotid artery during endoscopic endonasal surgery:surveys f skull base surgeons. (hopkinsmedicine.org)
- Surgery may also be necessary if the injury causes a narrowing of the spinal canal in your neck. (spineuniverse.com)
- Carotid Endarterectomy Surgery Step by Step - Photographs of carotid endarterectomy surgery. (searchbeat.com)
- Stroke Prevention - Carotid artery surgery in easy to understand text with nice graphics. (searchbeat.com)
Stroke10
- A beneficial effect of anticoagulation therapy with unfractionated heparin has been demonstrated, with a reduction of the ischaemic stroke rate from 29.8% to 3.9% [7] in grade I - IV injuries. (scielo.org.za)
- Inflammation plays an essential role for destabilization and rupture of carotid atherosclerotic plaques causing embolic ischemic stroke. (springer.com)
- Conclusions: In the majority of BCVI cases there is a variable latent period between the time of injury and the development of stroke. (jccm.ro)
- Frequently associated injuries were long bone fractures, stroke and intracranial hemorrhage, thoracic injuries, and pelvic fractures which are likely associated with the force/mechanism of injury. (dcorthoacademy.org)
- Glasgow Coma Score (GCS) of 12 or less, or stroke with hemi-paresis signifying a moderate to severe acquired brain injury . (tripdatabase.com)
- Spinal manipulation has been suggested as a potential cause of cerebrovascular accidents (eg, stroke) through mechanical injury to the vertebral artery. (aappublications.org)
- The vertebral artery supplies the part of the brain that lies in the posterior fossa of the skull, and this type of stroke is therefore called a posterior circulation infarct . (wikipedia.org)
- Carotid Artery Disease - Features information about the disease and the increased risk it brings for stroke. (searchbeat.com)
- When to Operate in Carotid Artery Disease - When to operate in carotid artery disease by Jose Biller, M.D. and William H. Thies, PH.D. American Academy of Family Physicians present the recent stroke trials in language we can all understand. (searchbeat.com)
- Ocular Manifestations of Carotid Artery Disease - A specific type of vision problem is one of the classic signs of a TIA (transitory ischemic attack) which is frequently a precursor to a stroke. (searchbeat.com)
Neointimal2
- In order to investigate the underlying mechanism of neointimal formationin in injured carotid arteries, all genes involved in signaling pathways whose expression was altered 2-fold in injured carotid arteries at day 7 and day 21 as compared to uninjured arteries were filtered out. (datamed.org)
- Temporal control of drug delivery may facilitate endothelial healing after injury, as NPs may be used to deliver antiproliferative agents to the vascular wall when neointimal proliferation is most active, followed by complete degradation and clearance ( 18 ). (pnas.org)
Denudation3
- IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. (nih.gov)
- Here we report that in a mouse model of carotid denudation, IL-10 knock-out mice (IL-10KO) displayed significantly delayed Re-endothelialization and enhanced neo-intimal growth compared to their WT counterparts. (nih.gov)
- After carotid artery balloon denudation, bortezomib was immediately administered by tail vein injection (systemic treatment) and by using an F-127 pluronic gel (perivascular treatment). (bvsalud.org)
Neointima7
- Conclusions -Diet-induced hyperhomocysteinemia, even mild to moderate, exacerbates neointima formation after denuding injury, making hyperhomocysteinemia a likely risk factor for postangioplasty restenosis. (ahajournals.org)
- Abstract -Injury-caused dedifferentiation accompanied by proliferation and migration of smooth muscle cells (SMCs) is an important process in the development of the neointima. (ahajournals.org)
- Two weeks after the injury, we compared the degree of neointima formation in the carotid artery and the tissue expression patterns of NF-kappaB and I-kappaBalpha. (bvsalud.org)
- Bortezomib suppressed NF-kappaB activation through the inhibition of I-kappaBalpha degradation, and significantly reduced neointima formation in a rat carotid artery injury model. (bvsalud.org)
- Here we studied the intracellular mechanisms by which 2-ME inhibits SMC growth and whether 2-ME prevents injury-induced neointima formation. (ahajournals.org)
- Antimitotic therapies used in cancer may also protect against vascular disorders 4 because abnormal growth of vascular smooth muscles (SMCs) contributes to vascular remodeling, such as neointima formation, atherosclerosis, and injury-induced restenosis. (ahajournals.org)
- In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. (jci.org)
Endarterectomy3
- Does carotid stenting measure up to endarterectomy? (semanticscholar.org)
- Carotid Endarterectomy and Carotid Artery Stenting in the Light of ICSS and CREST Studies. (bioportfolio.com)
- Diagnosis and Management of Carotid Artery Occlusive Disease - Plan for preoperative evaluation of a patient before carotid endarterectomy. (searchbeat.com)
Mouse model of carotid1
- In this study we investigated whether the use of an elastin-binding contrast agent would allow the detection of vascular remodeling in a mouse model of carotid artery injury and whether it would facilitate the detection of impaired ECM formation in CRP2-/- mice. (biomedcentral.com)
Revascularization2
- The purpose of this study is to describe the changes in morphology and Retinal vascularization after revascularization of the internal carotid artery. (clinicaltrials.gov)
- The underlying hypothesis is that revascularization of the internal carotid artery would improve ipsilateral and retinal homolateral perfusion in the short term. (clinicaltrials.gov)
Left common2
- The bullet entered through the left anterior neck and severed the left common carotid artery. (biomedsearch.com)
- Clodronate (0.1 mL/10 g) was injected via the tail vein starting 2 days (d-2) before left common carotid artery injury. (elsevier.com)
Cerebrovascular injuries3
- The anatomic variability of the collateral circulation helps explain the clinical presentations of patients with cerebrovascular injuries, and underscores the need for complete imaging of cerebral circulation when injury is suspected. (uptodate.com)
- Screening for blunt cerebrovascular injuries: analysis of diagnostic modalities and outcomes. (springer.com)
- Optimizing screening for blunt cerebrovascular injuries. (springer.com)
Dissections3
- Although cerebral artery dissections are potentially fatal, there is still a lack of knowledge related to their natural history and adequate treatment options. (signavitae.com)
- Four patients with traumatic internal carotid artery dissections were identified during the 8- year period under study. (elsevier.com)
- These data suggest that internal carotid artery dissections may be underrecognized sequelae of direct softball injuries to the anterolateral neck. (elsevier.com)
Hyperplasia7
- IL-10 deletion reduces ReEndo and increases neo-intimal hyperplasia after carotid artery injury. (nih.gov)
- C-D) For morphometric analysis, 28 days after injury carotid artery were isolated and neo-intimal hyperplasia was measured by Elastic Trichome (ET) staining. (nih.gov)
- IL-10 KO mice showed excessive intimal hyperplasia after wire injury. (nih.gov)
- ReEndo and intimal hyperplasia in the denuded mouse carotid arteries was measured after IL-10 or IgG (50μg/kg each) ( A ) Representative photomicrographs of Evans blue stained arteries. (nih.gov)
- These results suggest that NO inhibition of intimal hyperplasia may be mediated by enhancing the recovery of injury-caused downregulation of paxillin. (ahajournals.org)
- Balloon catheter -induced injury was adopted to induce intimal hyperplasia of the carotid arteries in rats . (bvsalud.org)
- Dot blot showed the expression of antisense TR mediated by recombinant LXSN ATR plasmid / nanoparticle complex in the wall of common carotid arteries of the experimental group rats , which enabled to inhibit TR gene expression and intimal hyperplasia of the injured arteries . (bvsalud.org)
Patients with carotid1
- This experience suggests that repair is safe and effective in patients with carotid injuries in whom prograde flow continues and only mild neurologic deficits are present. (elsevier.com)
Abstract1
- abstract = "Objectives: As the adoption of endoscopic endonasal approaches (EEA) continues to proliferate, increasing numbers of internal carotid artery (ICA) injuries are reported. (fujita-hu.ac.jp)
Blunt carotid arterial2
- Blunt carotid arterial injury (BCI) is a rare injury associated with motor vehicle collision (MVC). (dcorthoacademy.org)
- The unrecognized epidemic of blunt carotid arterial injuries: early diagnosis improves neurologic outcome. (springer.com)
Murine carotid1
- Moreover, recent work from our laboratory has demonstrated that hyperglycemia inhibits medial VSMC apoptosis in the murine carotid artery in response to a reduction in blood flow ( 10 ). (diabetesjournals.org)
Intracranial portion1
- S06.815A is an initial encounter code, includes a 7th character and should be used while the patient is receiving active treatment for a condition like injury of right internal carotid artery intracranial portion not elsewhere classified with loss of consciousness greater than 24 hours with return to pre-existing conscious level. (icdlist.com)
Endothelial2
- Because homocysteine is known to exert a direct inhibitory effect on endothelial cell growth in vitro, we hypothesized that this effect contributes to the progression of atherosclerotic lesions initiated by endothelial damage caused by mechanical injury. (ahajournals.org)
- Angpt2 was highly expressed in endothelial cells at the infarct border zone after myocardial infarction (MI) or ischemia/reperfusion injury in mice. (jci.org)
Proximal1
- Segments of injured artery and segments proximal and distal to the area of injury were removed 3, 7, and 21 days after balloon dilatation. (ox.ac.uk)
Posterior4
- Given the presence of good collateral flow through the anterior and posterior communicating arteries, the right ICA was sacrificed by coil embolization. (cureus.com)
- A neurysms arising from the internal carotid artery (ICA) between the site of emergence of the carotid artery from the roof of the cavernous sinus and the origin of the posterior communicating artery (PCoA) have traditionally been termed "ophthalmic artery aneurysms" since the ophthalmic artery is the chief vessel arising from this segment. (thejns.org)
- The vascular supply to the brain is divided into the anterior and posterior circulations originating from the carotid and vertebral arteries, respectively. (uptodate.com)
- While the anterior ligaments are only involved in 2% of injuries, the posterior ligaments are involved in 16% of injuries. (chiro.org)
Right internal carotid2
- During resection of the middle fossa component of a large ventral skull base chondrosarcoma, arterial bleeding was encountered near the right internal carotid artery (ICA). (cureus.com)
- Back in January 2014, I somehow managed to tear my right right internal carotid artery. (medhelp.org)
19941
- Cell adhesion molecules in coronary artery disease (1994) Jang Yangsoo et al. (naver.com)
Arterial injury3
- Previously, we reported the engineering of collagen IV-targeting nanoparticles (NPs) and demonstrated their preferential localization to sites of arterial injury. (pnas.org)
- Inflammation following arterial injury mediates vascular restenosis, a leading cause of cardiovascular morbidity. (nih.gov)
- We demonstrate that the macrophage response to arterial injury can be imaged in vivo using IVM-based molecular imaging, and shows a higher macrophage influx at day 14 compared to day 28 post-injury. (nih.gov)
Morbidity and morta2
- The morbidity and mortality of carotid arterial injuries in 36 patients were retrospectively reviewed. (elsevier.com)
- Neck injuries are rare but carry significant morbidity and mortality. (springer.com)
Severe7
- A 14-year-old boy with severe traumatic brain injury (TBI) and cranial fractures was admitted to our emergency department after a motor vehicle accident. (signavitae.com)
- This report details the clinical observation, accompanied by radiological images, of tCAD at the supraclinoid portion after severe traumatic brain injury (TBI) in a child. (signavitae.com)
- Treatment and outcome depend on how severe the injury is. (icdlist.com)
- People with severe injuries usually need rehabilitation. (icdlist.com)
- In the exploratory multi-center Phase 2 a study safety, tolerability, pharmacodynamics and pharmacokinetics of the Nitric Oxide Synthase inhibitor VAS203 is assessed in patients with moderate and severe traumatic brain injury. (clinicaltrials.gov)
- Sudden severe injury to the neck may also contribute to disc herniation, whiplash , blood vessel destruction, vertebral bone or ligament injury and, in extreme cases, permanent paralysis. (aans.org)
- In the past, blunt carotid injury was associated with mortality rates ranging from 23 to 28 percent, with 48 to 58 percent of survivors suffering permanent severe neurologic deficits [ 1 ]. (uptodate.com)
Ligation3
- Lucas, Charles E. / Primary Repair vs Ligation for Carotid Artery Injuries . (elsevier.com)
- (h) Permanent ligation of the EC, followed by release of the clamp and return of blood flow through the IC artery. (nih.gov)
- We investigated whether the absence of cGKI in SMCs would affect vascular remodeling after carotid ligation or removal of the endothelium. (nih.gov)
Coronary artery1
- Following recent successes with percutaneous coronary intervention (PCI) for treating coronary artery disease (CAD), many challenges remain. (pnas.org)
Common carotid4
- the right common carotid is a branch of the brachiocephalic artery. (thefreedictionary.com)
- in the neck, between the level of the top of the trachea and the floor of the mouth, each common carotid artery divides into an internal and an external carotid artery. (thefreedictionary.com)
- Extracranial arterial injuries to the brachiocephalic, common carotid, and vertebral arteries can result in major neurologic deficits. (medscape.com)
- EC = external carotid artery, IC = internal carotid artery, CC = common carotid artery. (nih.gov)
External carotid3
- Each divides into an external carotid and an internal carotid. (thefreedictionary.com)
- Branches of the external carotid supply the face, scalp, and most of the neck and throat tissues. (thefreedictionary.com)
- objectives: Dura of the anterior clinoid process (ACP) is presumably supplied by the ophthalmic and external carotid artery branches. (bioportfolio.com)
Stents2
- Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits. (semanticscholar.org)
- Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation. (bioportfolio.com)
NECK INJURIES4
- Penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures in the neck. (biomedsearch.com)
- Awareness of the various presentations of neck injuries and the establishment of a well-conceived multidisciplinary plan prior to the traumatic event is critical for improving patient outcome. (medscape.com)
- The neck is divided into anatomic zones or regions to assist in the evaluation of neck injuries. (medscape.com)
- Also during the time that technology had been advancing, many reports have documented the safety of selective management of neck injuries that penetrate the platysma. (east.org)