Carnosine: A naturally occurring dipeptide neuropeptide found in muscles.Anserinebeta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.Dipeptidases: EXOPEPTIDASES that specifically act on dipeptides. EC 3.4.13.Dipeptides: Peptides composed of two amino acid units.Performance-Enhancing Substances: Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. The substances can include PRESCRIPTION DRUGS; DIETARY SUPPLEMENTS; phytochemicals; and ILLICIT DRUGS.Glycylglycine: The simplest of all peptides. It functions as a gamma-glutamyl acceptor.Omasum: The third stomach of ruminants, situated on the right side of the abdomen at a higher level than the fourth stomach and between this latter and the second stomach, with both of which it communicates. From its inner surface project large numbers of leaves or folia, each of which possesses roughened surfaces. In the center of each folium is a band of muscle fibers which produces a rasping movement of the leaf when it contracts. One leaf rubs against those on either side of it, and large particles of food material are ground down between the rough surfaces, preparatory to further digestion in the succeeding parts of the alimentary canal. (Black's Veterinary Dictionary, 17th ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Physician-Patient Relations: The interactions between physician and patient.Research Personnel: Those individuals engaged in research.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.MoscowUSSRHistamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.RussiaBipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Zinc Compounds: Inorganic compounds that contain zinc as an integral part of the molecule.Hospitals, State: Hospitals controlled by agencies and departments of the state government.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Histidine: An essential amino acid that is required for the production of HISTAMINE.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)Ophthalmic Solutions: Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.Cataract Extraction: The removal of a cataractous CRYSTALLINE LENS from the eye.Veterinarians: Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Lens, Crystalline: A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Zinc Fingers: Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Probiotics: Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Sound: A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)Consumer Satisfaction: Customer satisfaction or dissatisfaction with a benefit or service received.

Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. (1/198)

BACKGROUND: Polaprezinc has been shown to exert an anti-oxidant property in a tube experiment, protect gastric mucosa from experimental ulcerations in vivo, and accelerate the healing of gastric ulcer in humans. AIM: To examine a possible protective effect of polaprezinc on oxidant-mediated injury in primary monolayer cultures of rat gastric fundic mucosa. METHODS: Cytotoxicity was quantified by measuring 51Cr release. Whether or not polaprezinc exerts an antioxidant property was investigated by determining the effect of this agent on hydrogen peroxide (H2O2)-induced injury. The effects of polaprezinc on superoxide (O2-. ) generation as well as on ethanol (EtOH)-induced injury were also examined. Generation of O2-. was assessed by the reduction in cytochrome c. RESULTS: H2O2 caused a time- and dose-dependent increase in 51Cr release. The dose-response curve of 51Cr release by H2O2 shifted to the right in the presence of polaprezinc. Polaprezinc, at submillimolar concentrations, prevented H2O2-induced 51Cr release. EtOH also caused a dose-dependent increase in 51Cr release, which was prevented by the addition of polaprezinc. The incubation of cells with EtOH caused an increase in cytochrome c reduction, as the concentrations of EtOH increased. Polaprezinc inhibited EtOH-induced cytochrome c reduction. Protection by polaprezinc was microscopically associated with the prevention of monolayer disruption. CONCLUSIONS: Polaprezinc is antioxidative and directly protects gastric mucosal cells from noxious agents through its antioxidant properties in vitro. This finding may provide the theoretical basis for the usage of an antiulcer drug with antioxidant properties for the treatment of gastric inflammation, such as that induced by ethanol.  (+info)

Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection. (2/198)

AIM: To evaluate the efficacy of polaprezinc, a mucosal protective agent, in combination with a 7-day triple therapy containing lansoprazole, amoxycillin and clarithromycin, as a treatment for Helicobacter pylori. METHODS: Sixty-six consecutive patients suffering from dyspeptic symptoms with H. pylori infection were randomly allocated to one of two regimens: one group (LAC; n = 31) received lansoprazole 30 mg b.d., amoxycillin 500 mg b.d. and clarithromycin 400 mg b.d. for 7 days. The other group (LACP; n = 35) received the LAC regimen plus polaprezinc 150 mg b.d. for 7 days. H. pylori status was evaluated by rapid urease test, histology and culture at entry and 4 weeks after treatment. RESULTS: Five patients did not complete the treatment: no follow-up endoscopy was performed on two patients in the LAC group; one patient in the LAC group and two in the LACP group had their treatment stopped due to severe diarrhoea. By per protocol analysis, H. pylori eradication was achieved in 24 of the 28 evaluable patients (86%; 95% CI: 72-100%) after LAC therapy, and in 33 of the 33 evaluable patients (100%) after LACP therapy (P < 0.05). On intention-to-treat analysis, the rates of eradication were 24 of 31 patients (77%; 95% CI: 62-93%) in the LAC group, and 33 of 35 patients (94%; 95% CI: 86-100%) in the LACP group (P < 0.05). CONCLUSION: A 7-day triple therapy with lansoprazole, amoxycillin and clarithromycin is effective in H. pylori eradication, but this regimen is significantly improved by the addition of polaprezinc.  (+info)

Carnosine stimulates vimentin expression in cultured rat fibroblasts. (3/198)

Two-dimensional electrophoretic gel profiles were compared between rat 3Y1 fibroblasts cultured in the presence and absence of 30 mM L-carnosine (beta-alanyl-L-histidine) for one week without any replenishment of medium. While a number of cellular proteins changed their expression levels by the addition of carnosine, we identified one of the most prominently varied proteins as vimentin. Immunoblot analysis with anti-vimentin antibody demonstrated that the vimentin levels increased about 2-fold after one-week culture in the presence of carnosine. We also confirmed that the increase of vimentin expression was dependent on the concentration of carnosine added to the medium. Moreover, when cultured cells were stained with anti-vimentin antibody and observed by light microscopy, most cells grown in the presence of carnosine were found to have markedly developed vimentin filaments. The increase of vimentin expression was also observed by adding with carnosine related dipeptides, N-acetylcarnosine and anserine.  (+info)

Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells. (4/198)

Gastric epithelial chemokine response is a primary factor in the induction of gastric inflammation associated with Helicobacter pylori infection. Because sustained inflammation is a risk for gastric mucosal damage, agents that down-regulate inflammatory responses may be of therapeutic significance. We examined the effect of polaprezinc, a potent antiulcer agent, on proinflammatory cytokine-induced interleukin (IL)-8 expression in gastric epithelial cells. Because IL-8 expression is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB), we also examined the effect of polaprezinc on NF-kappaB activity. MKN28 cells were used as a model of gastric epithelial cells. Secreted IL-8 was quantified by IL-8 specific enzyme-linked immunosorbent assay, and IL-8 mRNA expression was examined by Northern blot analysis. NF-kappaB activity was analyzed by electrophoretic mobility shift assay. Western blot analysis with anti-phospho-IkappaB-alpha antibody was performed to assess IkappaB-alpha phosphorylation. Polaprezinc-suppressed IL-8 secretion induced by tumor necrosis factor alpha (TNF-alpha) or IL-1beta in a dose-dependent manner. IL-8 mRNA expression also was inhibited by polaprezinc. NF-kappaB activation in response to TNF-alpha, IL-1beta, phorbol ester, and H(2)O(2) was down-regulated by polaprezinc. Western blot analysis showed inhibition of TNF-alpha-induced IkappaB-alpha phosphorylation in the presence of polaprezinc. Collectively, these results suggest that polaprezinc is a novel type of anti-inflammatory agent that down-regulates inflammatory responses of gastric mucosal cells.  (+info)

Hydrogen peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserine. (5/198)

The fragmentation of human Cu,Zn-superoxide dismutase (SOD) was observed during incubation with H(2)O(2). Hydroxyl radical scavengers such as sodium azide, formate and mannitol protected the fragmentation of Cu,Zn-SOD. These results suggested that *OH was implicated in the hydrogen peroxide-mediated Cu,Zn-SOD fragmentation. Carnosine, homocarnosine and anserine have been proposed to act as anti-oxidants in vivo. We investigated whether three compounds could protect the fragmentation of Cu,Zn-SOD induced by H(2)O(2). The results showed that carnosine, homocarnosine and anserine significantly protected the fragmentation of Cu,Zn-SOD. All three compounds also protected the loss of enzyme activity induced by H(2)O(2). Carnosine, homocarnosine and anserine effectively inhibited the formation of *OH by the Cu,Zn-SOD/H(2)O(2) system. These results suggest that carnosine and related compounds can protect the hydrogen peroxide-mediated Cu,Zn-SOD fragmentation through the scavenging of *OH.  (+info)

Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol. (6/198)

Antimalarial screening was performed for microbial metabolites that simulate artemisinin in their mode of action, a potent antimalarial component of an herbal remedy with a characteristic peroxide structure. Nanaomycin A was identified in this screen as an antimalarial compound, together with radicicol and several other compounds already reported (J. Antibiotics 51: 153 approximately 160, 1998). Nanaomycin A inhibited in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. It was as potent as radicicol and about 1/10 as potent as artemisinin. Studies on the mode of action suggested that the antimalarial action of the two non-peroxides, nanaomycin A and radicicol, involved heme-dependent radical generation, as is for the peroxide artemisinin. Namely, the inhibition of in vitro growth of malaria parasite by nanaomycin A or radicicol was reversed by tocopherol, a radical scavenger added to the assay mixture. Secondly, in a reaction system established for radical detection, in which a test radical donor and beta-alanylhistidine as a radical recipient were incubated with and without hemin, the two compounds caused heme-dependent decreases of beta-alanylhistidine, as did artemisinin. Among the 14 microbial metabolites identified during this screening, a correlation was observed between antimalarial activity and heme-dependent radical generating activity.  (+info)

Amino acid flux in ruminal and gastric veins of sheep: effects of ruminal and omasal injections of free amino acids and carnosine. (7/198)

The possibility of free amino acid (FAA) and peptide absorption across the ruminant stomach wall was studied in multicatheterized wethers fed every 12 h. During the last third of the feeding cycle, two intraruminal or intraomasal injections of solutions containing increasing amounts of Ser, Gly, Val, Met, Phe, Lys, and carnosine were successively performed. Before injections, a net uptake of each of these FAA was measured in the ruminal and the gastric veins. The ruminal injections produced a linear increase in ruminal FAA concentration. The highest ruminal concentrations (observed with 3 g of FAA and carnosine) ranged between 5 and 14 mM. After ruminal injections, Ser (P < .05), Gly (P < .05), Val (P < .05), Met (P < .10), and Lys (P < .10) uptake decreased and carnosine net release linearly increased (P < .05), suggesting absorption across the ruminal epithelium. Owing to the low net flux generated by high ruminal concentration, the ruminal epithelium permeability to these molecules seemed to be low. After omasal injections, net flux of injected FAA were not modified, suggesting a low permeability of the gastric epithelia to FAA. Carnosine net release linearily increased (P < .05) with increasing level of carnosine injection, indicating the possibility of dipeptide absorption at the gastric level. This study demonstrated in vivo that the stomach epithelia possess the capacity to absorb FAA and small peptides; however, the permeability of these epithelia to these molecules seemed limited.  (+info)

Effects of carnosine and related compounds on the stability and morphology of erythrocytes from alcoholics. (8/198)

The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These beneficial properties of the dipeptides do not appear to be directly related to their antioxidant or buffering properties.  (+info)

Carnosine (β-alanyl-L-histidine) is a dipeptide abundant in mammalian skeletal muscles [1, 2]. Various physiological actions have been ascribed to carnosine in muscle, including acting as an antioxidant [3], regulating Ca2+ sensitivity [4], protecting proteins against glycation by acting as a sacrificial peptide [5], and preventing the formation of protein-protein cross links by reacting with protein-carbonyl groups [6]. Primarily, carnosine with pH buffering capacity is widely used in the field of sports nutrition [7]. Because the dissociation exponent (pKa) of carnosine is 6.83 [8, 9], it is suggested that carnosine attenuates the reduction in blood pH by a large amount of H+ originating from the dissociation of lactic acid during strenuous exercise, and suppresses a loss of force [10]. At the same time, muscle carnosine contents are positively correlated with high-intensity exercise performance [11] and fast-twitch muscle fibers [12]. Increase of muscle carnosine predominantly was due to the ...
Zinc L-carnosine (beta-alanyl-L-histidinato zinc) (N-(3-aminopropionyl)-L-histidinato zinc), often simply called zinc carnosine, and also known as polaprezinc, is a mucosal protective chelate compound of zinc and L-carnosine. It is a quadridentate 1:1 complex of a polymeric nature. It contains 23% zinc and 77% L-carnosine by mass. It is an approved drug in Japan where it is clinically used to treat gastric ulcers. Its mechanism of action is believed to oxygen radical scavenging, anti-oxidation, and acceleration of gastrointestinal wound healing. It exhibits ROS-quenching activities. It can remain in the stomach without rapid dissociation and adhere specifically to ulcerous lesions, after which L-carnosine and zinc are released to heal the ulcer. It has been shown to stimulate mucus production and to maintain the integrity of the gastric mucosal barrier. In summary, it maintains homeostasis of the gastric mucosa by prostaglandin-independent cytoprotective effects due to anti-oxidative membrane ...
L-Carnosine Reduces Glycation L-Carnosine is a dipeptide composed of the amino acids beta-alanine and L-histidine. It occurs naturally in muscle, brain and other tissues in high concentrations. In in vitro studies, L-carnosine reduced glycation, a process in which DNA and protein are damaged by glucose. The end products of glycation are highly reactive molecules called advanced glycation end products (AGEs), which can further damage proteins, lipids and nucleic acids. The accumulation of AGEs is associated with aging. Supplement Facts for 500 mg Tablet Serving Size: 1 tablet(s) Amount Per Serving - % Daily Value Calcium 88 mg 8% L-Carnosine 500 mg Other Ingredients: dibasic calcium phosphate, microcrystalline cellulose, stearic acid, hydroxypropyl cellulose, colloidal silicon dioxide, and modified cellulose gum. Warning: If you are pregnant, may become pregnant, or breastfeeding, consult your physician before using this product. Suggested Use: 1 to 3 tablets daily with meals.
Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. It is a dipeptide of the amino acids beta-alanine and histidine. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies (PMID 16804013 ). It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the "hyperactivity" seen in autistic subjects at higher doses. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability (PMID 16406688 ...
L-Carnosine is a dipeptide composed of the covalently bonded amino acids alanine and histidine. In studies, L-Carnosine has been shown to provide free radical protection. It is found in the brain, heart, skin and muscles. Directions: As a dietary supplement, take one tablet up to two times daily with meals of a glass of water. Serving Size: 1 Tablet 30 Servings per container Ingredients: Amount per serving: % Daily Value: + Dietary Fiber 1 g 2% Total Carbohydrate 1 g % L-Carnosine 500 mg ~ Key to Ingredients: Daily Value not established. Percent Daily Value is based on a 2,000 calorie diet. Values differ depending on age Values differ depending on age Other Ingredients: Cellulose, Stearic Acid and Silica.
When present, L-Carnosine has cell life extending properties and is well known to extend the life span of cells as they approach the Hayflick limit. L-Carnosine is able to reverse the signs of aging cells and is a telomere protector. In lab testing cells treated with L-Carnosine had a cell division increase of an astounding 300%. Studies have shown that rats treated with L-Carnosine have significantly reduced outward signs of old age and are twice as likely to achieve their maximum age ...
1) Dunnett M., R.C. Harris. Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius. Equine Vet J. 30 (suppl): 499-504, 1999.. 2) Dunnett M., Harris RC, Dunnett CE, Harris PA. Plasma carnosine concentration: Diurnal variation and effects of age, exercise and muscle damage. Equine Vet J Suppl; Sept 2002. (34): 283-7. 3) Harris R. C. Muscle Carnosine elevation with supplementation and training, and the effects of elevation on exercise performance. (ISSN conference, 2005).. 4) Harris RC, et al; The absorption of orally supplied beta-alanine and its effect on muscle carnosine sythesis in human vastus lateralis. Amino Acids; 2006 May; 30 (3): 279-289.. 5) Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA; Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2007 Feb: 32(2) 225-33. 6) Pottier, A, Ozdemir M, Reyngoudt H, Koppo K, Hrris R, Wise ...
TY - JOUR. T1 - L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent manner. AU - Cartwright, Stephanie P.. AU - Bill, Roslyn M.. AU - Hipkiss, Alan R.. N1 - © Cartwright et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.. PY - 2012/9/12. Y1 - 2012/9/12. N2 - The dipeptide L-carnosine (β-alanyl-L-histidine) has been described as enigmatic: it inhibits growth of cancer cells but delays senescence in cultured human fibroblasts and extends the lifespan of male fruit flies. In an attempt to understand these observations, the effects of L-carnosine on the model eukaryote, Saccharomyces cerevisiae, were examined on account of its unique metabolic properties; S. cerevisiae can respire aerobically, but like some tumor cells, it can also exhibit a metabolism in which aerobic ...
Carnosine is a dipeptide that is a derivative of the supplement known as beta-alanine. When saturated in the muscle, carnosine acts as a buffer to hydrogen i
L-Carnosine is classified as a dipeptide, which is a combination of two amino acids, in this case alanine and histidine. It naturally occurs in high concentrations in skeletal muscle tissue, and therefore may support muscle vitality. L-Carnosine is also an antioxidant that stabilizes cellular membranes, protecting them from damage by free radicals.* Because L-Carnosine is only found in vertebrates, it is especially important for persons who do not consume beef, pork or chicken.
OBJECTIVE:. It is our hypothesis that L-carnosine treatment of persons with bipolar illness will improve their cognitive outcomes, more specifically, measures of attention and executive function, verbal and visuospatial memory and psychomotor performance, relative to placebo treatment. We also hypothesize that L-carnosine treatment may secondarily improve any residual affective symptoms.. RESEARCH PLAN:. We aim to test these hypotheses by conducting a randomized, placebo controlled, add on treatment trial of L-carnosine (added to ongoing prescribed pharmacological treatment, for example - lithium, anticonvulsants, antipsychotic agents and depressants) for a period of 12 weeks. Measures of cognition, and psychopathology will be utilized for evaluating primary and secondary outcomes, along with safety assessments.. METHODS:. Up to 48 subjects with DSM IV TR bipolar I disorder will be recruited from Western Psychiatric Institute and Clinic, Mayview State Hospital and Mon Yough Community Services, ...
Beta-Alanine is a precursor to the amino acid Carnosine, which functions as a lactic acid buffer capable of reducing fatigue in the working muscle. Though it takes time to accumulate in muscle tissue, Beta-Alanine supplementation, for at least two weeks, is highly effective at increasing muscular Carnosine concentration.. One study in particular that measured the Carnosine levels of sprinters found that individuals with higher muscular Carnosine levels exhibited higher power output in the latter half of a 30m sprint (because they had less lactic acid build-up). Multiple studies have confirmed that Beta Alanine supplementation increases muscular Carnosine in a dose dependent manner. In particular, a 2012 study published in "Amino Acids" found that subjects who consumed 1.6 or 3.2 grams of Beta Alanine daily experienced significant increases in muscle Carnosine in as little as two weeks, with the higher dose achieving a higher concentration of Carnosine. The doses used in this study, 1.6 and 3.2g, ...
High-intensity exercise leads to reductions in muscle substrates (ATP, PCr6, and glycogen) and a subsequent accumulation of metabolites (ADP, P, H(+), and Mg(+)) with a possible increase in free radical production. These factors independently and collectively have deleterious effects on muscle, with significant repercussions on high-intensity performance or training sessions. The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H(+) concentration following high-intensity work. Carnosine, however, has other roles such as an antioxidant, a metal chelator, a Ca(2+) and enzyme regulator, an inhibitor of protein glycosylation and protein-protein cross-linking. To date7comma; only 1 study has investigated the effects of carnosine supplementation (not in pure form) on exercise performance in human subjects and found no improvement in repetitive high-intensity work. Much data has come from in vitro work on animal skeletal muscle fibers or ...
Pure Beta Alanine Powder Review, Benefits, Best Doses and Negative Side Effects. Why use Beta-Alanine Supplements to Boost Muscle Carnosine Concentrations?
Alanine also directly affects levels of carnosine in the body. Carnosine is a unique dipeptide that interferes with the glycation process. Levels of carnosine decline with age and carnosine supplements are not readily absorbed. Alanine supplementation is more effective at upgrading stores of carnosine in the body.. A simple definition of glycation is the cross-linking of proteins and sugars to form non-functioning structures in the body. Advanced glycation end-products (AGEs) are formed when sugars react with proteins, such as collagen, an essential component of healthy skin, which comprises up to one-third of the bodys proteins and has a slow turnover rate. AGEs threaten healthy skin by increasing collagen breakdown and reducing collagens regenerative ability. The result is wrinkling and sagging skin. Carnosine effectively prevents glycation from damaging the structure of skin, thus keeping skin firm, elastic and youthful.. Muscle carnosine content is inversely related to age. After the age ...
The typical effects of beta alanine (BA) supplementation is evident by the results of a new study. The study involved 18 high level rowers who used BA for 7 weeks at a dose of 5 grams a day. Other rowers ingested a placebo for the same amount of time. Before and after supplementation, muscle carnosine levels were measured, and performance was evaluated in a 2000 meter ergometer test. The baseline test showed a strong correlation between muscle carnosine levels in the rowers and speed at various distances. After the BA supplementation, carnosine content increased by 45.3% in the soleus muscle (slow-twitch) and 28.2% in the gastrocnemius muscle (fast-twitch). Performance testing also showed that the BA group was 4.3 seconds faster than the placebo group. Prior to BA, they were 0.3 seconds slower. Muscle carnosine levels was positively correlated to 2000 meter rowing performance. As such, carnosine was able to increase speed in these elite athletes. Strength wasnt measured in the study, although ...
The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA or carnosine supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007)
L-carnosine, known as beta-alanine-L-histidine, is a dipeptide containing two amino acids, alanine and histidine. It is an antioxidant, a chelator of toxic metals, a buffer, etc. L-carnosine may neutralize lactic acid and surprisingly the human muscle contains 20 mM carnosine while mouse muscle contains only 1 mM. The authors have studied the effect of l-carnosine […]. View Post ...
This powerful dipeptide amino acid is a combination of histidine and beta-alanine, and found in high concentrations of skeletal tissues. With its strong antioxidant and free radical fighting properties, NOW L-Carnosine is a sound way to protect the bodys most vital building blocks from many forms of cellular damage. And as one of the most effective anti-carbonylation agents in use today, L-Carnosine may have a positive impact on our ability to slow the effects of age-related degeneration by hindering production of abnormal proteins.
This study reports the synthesis and characterization of novel ruthenium (II) complexes with the polydentate dipeptide, L-carnosine (2-[(3-aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic acid). Mixed-ligand complexes with the general composition [MLp(Cl)q(H2O)r]·xH2O (M = Ru(II); L = L-carnosine; p = 3 − q; r = 0-1; and x = 1-3) were prepared by refluxing aqueous solutions of the ligand with equimolar amounts of ruthenium chloride (black-alpha form) at 60 °C for 36 h. Physical properties of the complexes were characterized by elemental analysis, DSC/TGA, and cyclic voltammetry. The molecular structures of the complexes were elucidated using UV-Vis, ATR-IR, and heteronuclear NMR spectroscopy, then confirmed by density function theory (DFT) calculations at the B3LYP/LANL2DZ level. Two-dimensional NMR experiments (1H COSY, 13C gHMBC, and 15N gHMBC) were also conducted for the assignment of chemical shifts and calculation of relative coordination-induced shifts (RCIS) by the complex formed.
GastricSoothe utilizes a compound of zinc and L-carnosine that soothes and protects the gastric mucosal lining. Zinc L-carnosine also acts as an antioxidant that scavenges free radicals and assists the bodys own system in restoring health
Department of Pathological Physiology, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Ado.) Translated from Byulleten Éksperimentalnoi Biologii i Meditsiny, Vol. 98, No. 11, pp. 603-604, November, 1984. ...
Low prices on L-Carnosine! Increasing carnosine (beta-ananyl-L-histidine) in muscles has been shown to enhance exercise performance in bodybuilders and other athletes. Carnosine gives muscles a boost that allows you to train at a higher intensity. It also delays muscular fatigue, extends endurance and shortens recovery time after training sessions.*
Carnosine is a naturally occurring combination of the amino acids alanine and histidine. In this novel formula carnosine is combined with benfotiamine, a fat soluble form of thiamine (vitamin B1), to help support healthy aging. Carnosine and benfotiamine are shown to possess antioxidant activity and collagen-supportive properties, and help with the inhibition of glycosylation of proteins caused by excessive glucose/fructose consumption. Made with non-GMO ingredients. ...
|BR| |SPAN class=noindent|Carnosine Supreme is a synergistic combination of two powerful naturally occurring anti-glycating and anti-aging agents, carnosine and benfothiamine. Carnosine Supreme is often recommended by doctors for diabetic patients who are
Treatment of low-dose aspirin (LDA)-induced small-bowel injury has not been established. Polaprezinc, a chelate of zinc and L-carnosine, may be efficacious for such injury. We conducted a pilot randomized controlled study to investigate whether polaprezinc is effective against LDA-induced small-bowel injuries. Consecutive patients under long-term (|3 months) LDA treatment and who agreed to participate in our study underwent initial capsule endoscopy (CE). Patients with LDA-induced small-bowel injury apparent upon initial CE (n = 20) were randomized into a polaprezinc (150 mg/day for 4 weeks) group and a control (no polaprezinc treatment) group. All underwent follow-up CE after 4 weeks. Changes in the number and characteristics of small-bowel mucosal injuries were compared within and between the two groups. The median number of reddened lesions and erosions/ulcers upon follow-up CE in the polaprezinc group significantly decreased (P | 0.05). However, there was no significant difference in the median
acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues.". "Carnosine and carnitine were discovered by Russian chemist V.Gulevich.[2] Researchers in Britain,[3] South Korea,[4] Russia[5][6] and other countries[7][8][9] have shown that carnosine has a number of antioxidant properties that may be beneficial. Carnosine has been proven to scavenge reactive oxygen species (ROS) as well as alpha-beta unsaturated aldehydesformed from peroxidation of cell membrane fatty acids during oxidative stress.". "Carnosine can oppose glycation[10][11] and it can chelate divalent metal ions. Chronic glycolysis is suspected to accelerate aging.[12] Carnosine was found to inhibit diabetic nephropathy by protecting the podocytes and mesangial cells.". "Carnosine containing products are also used in topical preparations to reduce wrinkles on the skin.". "Some studies have detected beneficial effects of N-acetylcarnosine in preventing and treating cataracts of the eyes; in one of these, ...
Beta-Alanine is a non-essential amino acid that is used by muscle cells to synthesize Carnosine. Carnosine is a dipeptide (Beta- Alanine plus Histidine) that functions as a buffer for the hydrogen ions (acid) produced during strenuous exercise, thus helping to maintain optimum muscular pH. NOW Sports uses CarnoSyn, a patented form of Beta-Alanine that has been clinically tested and shown to increase muscle Carnosine content, allowing muscles to work harder and longer during intense exercise. NOW Beta-Alanine is backed by scientific research demonstrating that CarnoSyn supplementation results in delayed muscle fatigue and rapid recovery time, thereby helping you attain your strength and endurance training goals. ...
Beta-Alanine is a non-essential amino acid that is used by muscle cells to synthesize Carnosine. Carnosine is a dipeptide (Beta- Alanine plus Histidine) that functions as a buffer for the hydrogen ions (acid) produced during strenuous exercise, thus helping to maintain optimum muscular pH. NOW Sports uses CarnoSyn, a patented form of Beta-Alanine that has been clinically tested and shown to increase muscle Carnosine content, allowing muscles to work harder and longer during intense exercise. NOW Beta-Alanine is backed by scientific research demonstrating that CarnoSyn supplementation results in delayed muscle fatigue and rapid recovery time, thereby helping you attain your strength and endurance training goals. ...
Buy our L-Carnosine Amino Acid tablets for a convenient way to increase your intake of carnosine and help repair your muscles quicker. Free delivery available.
Urgent need exists for new therapeutic options in ischemic stroke. We recently demonstrated that carnosine, an endogenous dipeptide consisting of alanine and histidine, is robustly neuroprotective in ischemic brain injury and has a wide clinically relevant therapeutic time window. The precise mechanistic pathways that mediate this neuroprotective effect are not known. Following in vivo administration, carnosine is hydrolyzed into histidine, a precursor of histamine. It has been hypothesized that carnosine may exert its neuroprotective activities through the histidine/histamine pathway. Herein, we investigated whether the neuroprotective effect of carnosine is mediated by the histidine/histamine pathway using in vitro primary astrocytes and cortical neurons, and an in vivo rat model of ischemic stroke. In primary astrocytes, carnosine significantly reduced ischemic cell death after oxygen-glucose deprivation, and this effect was abolished by histamine receptor type I antagonist. However, ...
Research indicates that carnosine has powerful antioxidant properties. Carnosine also appears to fight oxidative stress and reduce inflammation. Its thought that carnosines antioxidant, anti-inflammatory effects could help protect against a number of aging-related conditions (such as Alzheimers disease and cardiovascular disease ...
Beta-alanine is the limiting substrate for the production of Carnosine. Carnosine (not carnitine) is the primary intracellular buffer for lactate....
L-Carnosine is a natural dipeptide compound formed from the amino acids, beta-alanine and histidine. It has been shown to decrease cellular aging, improve the appearance of the skin, and protect the brain and eyes from oxidative damage.
Carnosinemia, also called carnosinase deficiency or aminoacyl-histidine dipeptidase deficiency, is a rare autosomal recessive metabolic disorder caused by a deficiency of carnosinase, a dipeptidase (a type of enzyme that splits dipeptides into their two amino acid constituents). Carnosine is a dipeptide composed of beta-alanine and histidine, and is found in skeletal muscle and cells of the nervous system. This disorder results in an excess of carnosine in the urine, cerebrospinal fluid (CSF), blood and nervous tissue. Neurological disorders associated with a deficiency of carnosinase, and the resulting carnosinemia ("carnosine in the blood") are common. A variety of neurological symptoms have been associated with carnosinemia. They include: hypotonia, developmental delay, mental retardation, degeneration of axons, sensory neuropathy, tremors, demyelinization, gray matter anomalies, myoclonic seizures, and loss of purkinje fibers. The gene for carnosinase is located on chromosome 18, an ...
During high intensity exercise, lactic acid is formed in the muscles and splits into lactate and hydrogen ions (H+). These H+ ions cause the blood to become more acidic (a drop in pH) which is one of the main causes of fatigue for this type of exercise. When this acid build up occurs, the muscle losses contractility and strength thus making it impossible to continue to exercise at the same intensity. Therefore, to cope with this acidity the body uses buffers and one of these buffers is called carnosine.. Carnosine it made up of histidine and beta-alanine. We have plenty of histidine in our body, but a lack of beta-alanine. Therefore it is this lack of beta-alanine which effects how much carnosine there is. Therefore, beta-alanine supplementation may help to increase the amount of muscle carnosine, a buffer of acidity in high intensity exercise. The body may therefore be able to cope with higher levels acidification.. Who can benefit from using Beta-Alanine?. Beta-alanine works in high intensity ...
This thesis reports on investigations on the structure and reactivity of dipeptide-alkali metal complexes, a series of ruthenium bearing catalysts, dysprosium based single molecule magnets and organometallic di-cobalt complexes. A variety of experimental and theoretical methods was used dependent on the problem: collision induced dissociation, hydrogen/deuterium exchange reactions, gas phase reactions with \(D_2\), infrared multiple-photon dissociation and the determination of minimum energy structures, IR absorption spectra, transition states and electronic transitions based on density functional theory. A case study was carried out to explore the influence of alkali metal ions on the gas phase structure of the dipeptide Carnosine. CID experiments on protonated Carnosine and its alkali metal complexes in an ion trap resulted in different fragment pathways dependent on the size of the alkali metal. The complexation of small ions (\(Li^+\) and \(Na^+\)) promoted the cleavage of bonds in the ...
A leading theory proposes that GWI/CMI is the result of wartime exposure to a variety of factors including vaccinations, various chemicals and stress. These factors initiate prolonged production of inflammation, free radicals, and the resulting injury to the brain, nervous system and muscle tissue. Since carnosine has been shown to protect the brain and muscle cells from the sort of damage underlying GWI/CMI, a double-blind, placebo-controlled study was designed to determine if nutritional supplementation with L-carnosine would significantly improve pain, cognition and fatigue in GWI. The 12-week study involved 25 GWI subjects who were given L-carnosine at 500, 1000 and 1500mg increasing at four-week intervals or a placebo. Primary outcomes included measures assessing cognitive function; feelings of fatigue and pain; and activity levels. The only measure that showed consistent benefit was the influence of carnosine supplementation on improving mental function ...
One of the most sought after nutritious supplements to hit the business sector recently has been beta-alanine. Essentially, beta-alanine is an ancestor to the compound carnosine; which, works by "extinguishing" the acidic environment made by working muscles. On the off chance that the cell environment inside of the muscle turns out to be excessively acidic, then the muscle quits working-the hypothesis is that carnosine constricts the onset of an acidic domain permitting you to accomplish more work (lift more weights, run quicker, and so on). As you can envision this has gotten many people in the wellness and execution industry energized, in light of the fact that the more work you can do and weights you can lift, the greater, speedier, and more grounded you can get to be.. Carnosine is one of the synthesized in the body utilizing beta alanine and histidine. Since there is a wealth of free histidine in the circulatory system, taking beta alanine will add to higher carnosine levels in the cells. ...
Beta alanine is an amino acid which increases carnosine in the muscles which is needed to regulate Ph as too much acid results in muscle fatigue. Research shows that it reduces fatigue thereby improving performance, endurance and strength as well as improving aerobic activity and lean body mass. Studies have shown that beta-alanine supplements increase muscle carnosine concentrations by 58% in four weeks and 80% in 10 weeks.. L-Glutamine accounts for more than 60% of the free amino acid pool however, there is evidence that our body cannot produce enough glutamine during times of stress, as occurs during intense exercise. Endurance athletes can often suffer low glutamine levels results in muscle breakdown, diminished immune function and reduced performance. Supplementing glutamine can decrease protein degradation, exercise induced muscle damage and improve performance in endurance sports. It is recommended that endurance athletes supplement 6-8grams of glutamine pre-training, 0.5grams an hour ...
INCREASE STAMINA AND ENDURANCE WITH ATP BETA ALANINE! Support workout performanceCombat fatigue and muscle sorenessIncrease stamina and enduranceSupport high intensity exerciseBeta alanine supplementation increases muscle carnosine better than taking carnosine itself. Muscle carnosine is an intramuscular acidity buffer
Beta alanine supplementation increases muscle carnosine better than taking carnosine itself. Muscle carnosine is an intramuscular acidity buffer and...
Shop our wide selection of high-quality autism supplements & vitamins - carnosine, glutathione, probiotics. B complex, & enzymes. Trusted & safe products.
Glioblastoma (GBM) is a tumor of the central nervous system. After surgical removal and standard therapy, recurrence of tumors is observed within 6-9 months because of the high migratory behavior and the infiltrative growth of cells. Here, we investigated whether carnosine (β-alanine-l-histidine), which has an inhibitory effect on glioblastoma proliferation, may on the opposite promote invasion as proposed by the so-called
Purchase 4PLUS NUTRITION Beta A+ 100 cpr, or find your preferred Beta Alanine - Carnosine at the lowest price on Vitamincenter.it. Fast delivery service all over Europe.
0101]Particularly advantageous antioxidants are chosen from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (e.g. urocanic acid) and derivatives thereof, peptides such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (e.g. anserine), carotenoids, carotenes (e.g. alpha.-carotene, β-carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. ...
GAT Beta-Alanine supplementation has been shown to increase muscle carnosine levels which lead to improved physical performance during high-intensity exercise.* GAT Beta-Alanine can help you knock out more reps!. Beta-Alanine can help you knock out more reps!. Net Weight: 200g (100-Servings). ...
EXTENDS PERFORMANCE: Carnosine is regarded as one of the most powerful acid-buffering substances known to man. Produced by the body, its stored in cells and released in response to reduced pH. The problem is we produce only enough carnosine to complete day-to-day activities and to extend performance for short periods. Carnosine is composed of two aminos: histidine and, you guessed it, beta-alanine. BETA-ALANINEs specific purpose is to improve and extend performance ...
Carnosine is a dipeptide, two amino acids linked together, that is present in all cells, particularly in skeletal muscle and the brain. Carnosine acts to control damage from free radicals, acids and excess metal ions in order to prevent damage to cellular components. Increased concentrations of carnosine in muscle and other cells has been shown to increase endurance by removing byproducts of intense exertion and promote healthy aging by preventing the buildup of wastes.. ...
A compound found in chicken soup - carnosine - helps the bodys immune system to fight the early stages of flu, research has found. Super food: A compound found in chicken soup, called carnosine, helps the bodys immune system to fight the early stages of flu, researchers have found. by Ian Marber, Daily Mail. Chicken soup is good for the soul, they say. And as a homespun remedy for everything that might ail you during winter, there are few things as deliciously soothing.. But could such a broth be more than just a cold comfort? According to the latest scientific study, the answer is yes.. Research in the American Journal of Therapeutics showed that a compound found in chicken soup - carnosine - helped the bodys immune system to fight the early stages of flu.. But the authors warned this benefit ended as soon as the soup was excreted by the body, so that means you may need to have a fairly constant supply.. The study wasnt the first to look at this. More than a decade ago, Dr Stephen Rennard, ...
Dr. Karen Kan0 Comments. How to Combine LifeWave Carnosine Patches with Glutathione and Aeon Patches In this video, I teach you how to use the LifeWave Y-Age Carnosine anti-aging patch that Suzanne Somers is so fond of. She discusses how to integrate the LifeWave Y-Age Carnosine with the Y-Age Glutathione and Aeon Patches. http://www.youtube.com/watch?v=vNDcEURTrpY&list=UUFgGfef5J7M-p82Wa7iEQUA If you enjoyed this video please…. Learn More →. ...
There is provided a composition comprising carnosine, in which said composition comprises carnosine so that the amount of carnosine per ingestion is 0.7 μg/kg to 0.09 mg/kg, and which may take the for
Nutrition Surplus offers vitamin and mineral supplements,amino-acids,herbs,antioxidants and immune system formulas for optimal health,anti-aging and disease prevention.. ...
Beta Alanine Amino Acid increases Carnosine concentration in the skeletal muscle, delaying muscle fatigue and letting you work out for longer.
A 10-wk supplementation period with beta-alanine in adult rats caused a substantial increase in muscle carnosine and anserine levels. The increases were more pronounced for carnosine than for anserine and also more pronounced in oxidative (soleus and red gastrocnemius) than in glycolytic (white gastrocnemius) muscles. These nutritionally induced metabolic changes were accompanied by several, generally beneficial, adaptations in contractile function in MUs of the rat gastrocnemius. BA supplementation improved the twitch force of FF units and the maximum tetanic force of FR units and prolonged the half-relaxation time in slow units. As expected, it reduced the fatigability of FF units but only during the first 10 s after initiation of repeated fatiguing activity. Moreover, it enhanced the force potentiation of FR units normally observed during a standard fatigue test. Finally, supplementation reduced force decline of slow units during the first minute of repeated contractions evoked by ...
Abdelkader, H, Longman, MR, Alany, RG and Pierscionek, B (2016) Phytosome-hyaluronic acid systems for ocular delivery of L-carnosine. International Journal of Nanomedicine, 2016(11), pp. 2815-2827. ISSN (print) 1176-9114 Abdelkader, H., Pierscionek, B., Carew, M., Wu, Z. and Alany, R.G. (2015) Critical appraisal of alternative irritation models: three decades of testing ophthalmic pharmaceuticals. British Medical Bulletin, 113(1), pp. 59-71. ISSN (print) 0007-1420 Abdelkader, H., Wu, Z., Al-Kassas, R., Brown, J.E. and Alany, R.G. (2011) Preformulation characteristics of the opioid growth factor antagonist-naltrexone hydrochloride: Stability and lipophilicity studies. Journal of Drug Delivery Science and Technology, 21(2), pp. 157-163. ISSN (print) 1773-2247 Abdelkader, Hamdy, Swinden, Julian, Pierscionek, Barbara K and Alany, Raid G (2015) Analytical and physicochemical characterisation of the senile cataract drug dipeptide [Beta]-alanyl-L-histidine (carnosine). Journal of Pharmaceutical and ...
|h3||span style=color: #ff0000;|GAT Beta-Alanine - German Quality Beta Alanine!|/span||/h3| |p|GAT Beta Alanine – now in stock at Genesis – has been shown to raise muscle carnosine levels which lead to improved physical performance during h
The optimal dosing strategy for β-alanine is still being refined. Early research suggested that chronic loading over 6-12 weeks was ideal however; more recent research suggests that shorter 4-8 week periods may produce similar results. Trained individuals may have a better loading response than untrained individuals. A sustained or slow release form of (β-alanine) or splitting the daily dose over two doses (e.g. morning and evening) as well as taking the supplement a meal with a meal can help to maximise uptake into the muscles. After stopping supplementation, it takes ~15 weeks for muscle carnosine levels to return to starting concentrations.. ...
They are both constituents of chicken protein and a supplement made from chicken that contains anserin and carnosin at a natural ratio of 2:1 appears to actually boost both the physical and mental capacity in older individuals.
Supposedly much of Beta-Alanines effects come through boosting the synthesis of an intramuscular dipeptide (two amino acids) called carnosine. To function effectively, muscle cells rely on the powerful intracellular buffer carnosine to avoid becoming acidic (low pH) during exercise. If you want your muscles to remain strong and maintain powerful contractions, they need to be in an optimal pH range. If they dont and the pH drops below that optimal level, you have significantly less strength and fatigue more quickly. You know this is happening when you feel that familiar burn in your muscles (lactic acid building) or even when youre lifting heavy and reach muscular failure. Muscle pH has dropped and its largely a result of an increase in hydrogen ions (H+) which build up when you break down the high energy compound ATP during exercise (ATP is muscle energy). The breakdown of ATP and the subsequent rise in H+ concentrations occurs in all of our energy systems but is most prevalent in an energy ...
Literature References: Naturally occurring dipeptide found in large amounts in skeletal muscle. Also present in other tissues such as brain, cardiac muscle, kidney. Water soluble antioxidant; functions as a free-radical scavenger. Isoln: Gulewitsch, Amiradzibi, Ber. 33, 1902 (1900); Wolff, Wilson, J. Biol. Chem. 95, 495 (1932); 109, 565 (1935). Synthesis from histidine and b-iodo- or b-nitropropionyl chloride: Baumann, Ingvaldsen, ibid. 35, 271 (1918); Barger, Tutin, Biochem. J. 12, 406 (1918). Later syntheses: Sifford, du Vigneaud, J. Biol. Chem. 108, 753 (1935); R. A. Turner, J. Am. Chem. Soc. 75, 2388 (1953); F. J. Vinick, S. Jung, J. Org. Chem. 48, 392 (1983). Crystal structure: H. Itoh et al., Acta Crystallogr. 33B, 2959 (1977). Possible role in wound healing: D. E. Fischer et al., Proc. Soc. Exp. Biol. Med. 158, 402 (1978). Review of physiological properties and therapeutic potential: S. E. Gariballa, A. J. Sinclair, Age Ageing 29, 207-210 (2000). ...
A naturally occurring dipeptide, Carnosine (B-alanyl-L-histidine) is found in high concentrations in the brain and muscles. Recent studies suggest Carnosine supports Anti-aging and normal cell... View full product details » ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
hmmm . . . Guess it could. Though perhaps the effects would be less given that we would likely be using lower doses than in the studies?? I think you upset the balance of copper and manganese if you take high dose zinc on more than a short term basis too. Though, for starters all were trying to find out is can zinc reduce our symptoms - then if it did we would want to refine things. Also, unlike ppis, you can get zinc in low dose tablets, so it would be much easier to follow a tapered reducing dose. So perhaps anyone trying it should bear in mind that a rebound is theoretically possible and aim to taper off carefully . . . me thinks ...
Musashi Beta Alanine is a amino acid widely used to support endurance and strength training goals. Bata-alanine is the building block of carnosine, a molecule that acts to buffer acid in muscles. 100% Beta Alanine Lactic acid buffer Building blocks of carnosine Informed Sport Container Size: 120gServing Size: 1.2gServi
As these molecules started to accumulate, the availability of free, unprocessed carnitine decreased. This imbalance was linked to fuel-burning problems, that is, impairments in the cells combustion of both fat and glucose fuel. "We suspected that persistent increases in acylcarnitines in the rats were causing problems, and we could also see that the availability of free carnitine was decreasing with weight gain and aging," said Muoio, according to an August 12, 2009 news release, Carnitine supplements reverse glucose intolerance in animals. "It appeared that carnitine could no longer do its job when chronic metabolic disruptions were stressing the system. Thats when we designed an experiment to add extra carnitine to the rats diet." Muoio (at the time of the news release) also is a professor in the departments of medicine, pharmacology and cancer biology ...
Beta-alanín a L-histidín sú stavebnými jednotkami dipeptidu beta-alanyl-L-histidínu, známeho tiež pod názvom CARNOSINE. Jeho hlavnými úlohami sú podpora uvoľňovania antioxidantov, ničenie voľných radikálov a dokonca môže pôsobiť ako neurotransmiter.. CARNOSINE je dôležitou súčasťou kostrových svalov, je koncentrovaný aj v rýchlych svalových vláknach typu II. Viaže H + a odďaľuje pokles pH, preto umožňuje zvýšiť intenzitu a dĺžku tréningu. Ak teda podporíme tvorbu karnozínu dodaním jeho zložiek špecifickou formulu Scitec beta-alanín 120g zvýšime tým schopnosť svalov odbúrať škodlivú kyselinu mliečnu a zároveň zlepšíme ako regeneráciu organizmu tak aj jeho výkonnosť.. Výhody. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
1. ABSTRACT The chronic form of alcoholic skeletal myopathy is characterized by selective atrophy of Type II fibers and affects up to two thirds of all alcohol misusers. Plasma selenium and alpha-tocopherol are reduced in myopathic alcoholics compared to alcoholic patients without myopathy. Plasma carnosinase is also reduced in myopathic alcoholics, implicating a mechanism related to reduced intramuscular carnosine, an imidazole dipeptide with putative antioxidant properties. Together with the observation that alcoholic patients have increased indices of lipid peroxidation, there is evidence suggestive of free radical (i.e., unpaired electrons or reactive oxygen species) mediated damage in the pathogenesis of alcohol-induced muscle disease. Protein synthesis is a multi-step process that encompasses amino acid transport, signal transduction, translation and transcription. Any defect in one or more of the innumerable components of each process will have an impact on protein synthesis, as ...
Got the itch to train more? Train longer and harder with ATP Sciences Beta Alanine. Increase your carnosine levels and remove lactic acid for better performance. Increased Muscular Endurance Removes Lactic Acid Build Up Enhanced Recovery Elevates Caraosine Levels Beta-Alanine is known as a rate limiting amino acid,
Another additional benefit of Beta Alanine is that it is a completely natural ingredient, unlike many other supplements which seem to have ingredient lists which go on forever. They are also padded out with many artificial sweeteners and flavourings, none of which are beneficial to you, apart from creating a nice flavour for your taste buds! Beta Alanine also mixes with relative ease and can be consumed within a regular drink or combined together with other supplements to create a stack. Research has indicated that Beta Alanine combines well with many supplements, including creatine and branch chain amino acids (BCAAs) to produce an overall enhanced supplementation effect on the body.. Research has indicated that after as little as 4 weeks, supplementing with Beta Alanine can enhance carnosine levels within your body by as much as 60%. This is further enhanced after 10 weeks with levels rising to as much as 80%. With these enhanced levels and the effects Beta Alanine is known to exert, it is ...
Zinc Soothe is a zinc-carnosine complex consisting of elemental zinc as well as L-carnosine, a naturally occurring dipeptide (beta-alanine and L-histidine) found in muscle and brain tissue. More than 40 human and animal studies have demonstrated Zinc Soothe safely and effectively supports the stomachs own natural cell-protective mechanisms without interfering in the normal digestive process.*. ...
CITRULINE MALATE - enhances cellular metabolism, improves energy production and increases nitric oxide production by improving blood flow and thereby delivering more oxygen to nutrients to active muscle tissues. Citrulline Malate is also involved in removing ammonia from the body, a toxic byproduct of protein metabolism, and is supportive of the immune system. Beta Alanine, as well as helping the body to produce more L-carnosine, also supports oxygen delivery and aerobic efficiency. It can reduce lactic acid build up in the muscles and provides extra energy for the workout.. BETA ALANINE - is a non-essential amino acid which has been shown in studies to help increase endurance levels and strength while training. As with most Allmax products this product contains only Pharmaceutical Grade ingredients. You can either spread out your servings throughout the day or take them all prior to training. BETA-ALANINE can improve muscular strength and endurance to provide a more powerful training session. ...
A nutritionist said not to rule out H. Pylori, but from reading your posts on it you seem to be of the opinion that most people have it and are asympotmatic.. maybe I wiped out something in my stomach causing a very bad reaction? I have taken things since then to try and eliminate any infections and heal my stomach like zinc l-carnosine, mastic gum, and raw manuka honey. I thought I was having some success with the zinc, but then it got bad again a couple days ago. I know that pregnancy is going to cause some relaxation of the LES but I wouldnt think it would also cause indigestion and nausea with meals, I know thats not a normal symptom of pregnancy. I cant handle taking HCL so I have not tried anything aggressive in terms of upping stomach acid. The only probiotics Ive gotten is through Kombucha and raw milk lately. I would appreciate any insight you have ...
* found in: Alanine, Methionine, Leucine, L-Lysine mono hydrochloride, L-Cysteine·HCL, Monohydrate, L-Carnosine, Features CAS#: 56-41-7 ..
Use HEED as your one-source fuel supply whenever and wherever a sports drink is your preferred choice. Hammers top-of-the-line fuel utilizes an all-complex-carbohydrate formula as opposed to simple sugars, for consistent, long-lasting energy that wont cause energy fluctuations or stomach distress. Its robust electrolyte profile ensures proper hydration while L-carnosine delivers superb lactic-acid buffering to reduce muscle soreness. All this with a never syrupy, subtle flavor, and no foul after taste, either! ...
Use HEED as your one-source fuel supply whenever and wherever a sports drink is your preferred choice. Hammers top-of-the-line fuel utilizes an all-complex-carbohydrate formula as opposed to simple sugars, for consistent, long-lasting energy that wont cause energy fluctuations or stomach distress. Its robust electrolyte profile ensures proper hydration while L-carnosine delivers superb lactic-acid buffering to reduce muscle soreness. All this with a never syrupy, subtle flavor, and no foul after taste, either! ...
Use HEED as your one-source fuel supply whenever and wherever a sports drink is your preferred choice. Hammers top-of-the-line fuel utilizes an all-complex-carbohydrate formula as opposed to simple sugars, for consistent, long-lasting energy that wont cause energy fluctuations or stomach distress. Its robust electrolyte profile ensures proper hydration while L-carnosine delivers superb lactic-acid buffering to reduce muscle soreness. All this with a never syrupy, subtle flavor, and no foul after taste, either! ...
Use HEED as your one-source fuel supply whenever and wherever a sports drink is your preferred choice. Hammers top-of-the-line fuel utilizes an all-complex-carbohydrate formula as opposed to simple sugars, for consistent, long-lasting energy that wont cause energy fluctuations or stomach distress. Its robust electrolyte profile ensures proper hydration while L-carnosine delivers superb lactic-acid buffering to reduce muscle soreness. All this with a never syrupy, subtle flavor, and no foul after taste, either! ...
Use HEED as your one-source fuel supply whenever and wherever a sports drink is your preferred choice. Hammers top-of-the-line fuel utilizes an all-complex-carbohydrate formula as opposed to simple sugars, for consistent, long-lasting energy that wont cause energy fluctuations or stomach distress. Its robust electrolyte profile ensures proper hydration while L-carnosine delivers superb lactic-acid buffering to reduce muscle soreness. All this with a never syrupy, subtle flavor, and no foul after taste, either! ...
Lacta-Aid is a paste formulated to enhance the energy metabolism for performance horses at the cellular level. Converts blood sugar into readily available energy by limiting the production of lactic acid, and helps prevent tying up syndrome.Each oz contains 1,000 mg oleic acid, 900 mg L-carnosine, 900 mg linoleic acid, 700 mg calcium pa
Shop the best Natures Life Cal Mag Zinc Complex 360 Caps products at Swanson Health Products. Trusted since 1969, we offer trusted quality and great value on Natures Life Cal Mag Zinc Complex 360 Caps products.
CarnoSyn® is the proprietary, patented form of Beta-Alanine. Beta-Alanine is a naturally occuring beta amino acid produced in muscle tissue as a component of carnosine.
Hi Matt, Carnage does a solid job of providing 4,500mg of Beta-Alanine per serving. As Carnosine is a multi-functional dipeptide made up of Beta-Alanin
Raspberry Ketones. Filled with your everyday essential nutrients - Find Vitamins A, E & C. Lets not forget beta-carotene! African Mango. Known for its high soluble fiber to GET RID OF BODY FAT And its dozens of nutrients like amino acids, minerals And fatty acids. L-Carnitine. Allow L-Carnitine to boost the role of your Mitochondria, help you age healthily & fight against disease. Along with these amazing benefits, it impacts brain functions which can reverse Alzheimers associated Symptoms! L-Arginine. Increase the production of Human Growth Hormone And INCREASE METABOLISM all while PROMOTING WEIGHT LOSS!. Beta-Alanine. Keep yourself physically active as Carnosine aids the muscle in endurance all while playing a role in BUILDING LEAN MUSCLE! Tryptophan. An amino acid that helps to stabilize your moods & has a positive effect on healthy sleeping! Grapefruit. Low carbs & calories, high in anti-inflammatory ingredients & fiber to PROMOTE WEIGHT-LOSS And improve insulin-resistance! ...
Raspberry Ketones. Filled with your everyday essential nutrients - Find Vitamins A, E & C. Lets not forget beta-carotene! African Mango. Known for its high soluble fiber to GET RID OF BODY FAT And its dozens of nutrients like amino acids, minerals And fatty acids. L-Carnitine. Allow L-Carnitine to boost the role of your Mitochondria, help you age healthily & fight against disease. Along with these amazing benefits, it impacts brain functions which can reverse Alzheimers associated Symptoms! L-Arginine. Increase the production of Human Growth Hormone And INCREASE METABOLISM all while PROMOTING WEIGHT LOSS!. Beta-Alanine. Keep yourself physically active as Carnosine aids the muscle in endurance all while playing a role in BUILDING LEAN MUSCLE! Tryptophan. An amino acid that helps to stabilize your moods & has a positive effect on healthy sleeping! Grapefruit. Low carbs & calories, high in anti-inflammatory ingredients & fiber to PROMOTE WEIGHT-LOSS And improve insulin-resistance! ...
Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a [Ca(2+)]i rise, independent of sarcolemmal Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores. Photolytic H(+) uncaging from 2-nitrobenzaldehyde also raised [Ca(2+)]i, and the yield was reduced following inhibition of glycolysis or mitochondrial respiration. H(+) uncaging into buffer mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g., carnosine), and ATP can underlie the H(+)-evoked [Ca(2+)]i rise. Raising [H(+)]i tonically at one
Body attack beta alanine increased giving back a new amino acid, which flooded the market but this time strength and endurance training, that really has it all, and the effect of which will be felt from the first application. Beta is now not only in strength athletes on everyones lips, but also focusing alanine body attack. Beta alanine optimized building lean muscle mass by the buffering of acids. The amino acid is converted in the body to Carnosine, which can abpuffern the accumulating hydrogen ions (H +). Too many hydrogen ions in the muscles let drop the pH value, which leads to the rapid degradation of the muscles. In addition, lactic acid blocked the fat loss. Beta alanine body attack buffers from these acids and ensures an increased oxygen and nutrient supply to the muscles. Body attack beta alanine contains a very high proportion of nitrogen and increases muscular strength and muscular endurance, which increased retry count moving heavy weights with a noticeably as the nitrogen booster ...
Beta alanine is an amino acid used frequently as a sports supplement. It boosts carnosine synthesis and helps with fatigue and building lean muscle mass
Yet another customer, Sharon Boerger, diagnosed with congestive heart failure reported that her energy level is better than its been in years since she began taking our CoQ10. She said she was finally been able to clean her house from top to bottom. She also took the Liquid Carnosine Plus and reported that it has corrected her dyslexia and she was reading a book a day! On a personal note, my mother, also diagnosed with congestive heart failure has been taking CoQ10 for about a year. Last year she received a 36 on a radioactive test of heart muscle function (50 and up is normal function) - this year her heart muscle function was at 46! People tell her they dont know how she is so energetic at age 85 and she is getting ready fly to Italy for a vacation! People who take cholesterol lowering statin drugs, such as Sharon and my mother, are at risk for developing congestive heart failure, because these drugs deplete the bodys natural supply of CoQ10 which is necessary for heart muscle ...
Bet alanine can help ward off fatigue leading to more intense and longer training sessions. Many users experience intense vasodilatation/pumps from the very first dose of Beta Alanine as carnosine is a powerful precursor in generating nitric oxide synthase.
Bet alanine can help ward off fatigue leading to more intense and longer training sessions. Many users experience intense vasodilatation/pumps from the very first dose of Beta Alanine as carnosine is a powerful precursor in generating nitric oxide synthase.
What is beta alanine? It will help you gain muscle by leveraging carnosine in a war against the lactic acid that builds in your muscles when you work out.
Groupe Public Actif il y a 2 mois et 3 semaines. A few weeks and arrange a lifetime risk factor in late pregnancy, malignancy and the where to buy cytotec deviation may be toxic. Observe the color, texture, and any swelling or other abnormalities of the vestibular mucosa and. I dont actually think I could help out with this seminar because you shouldnt need one. He is not one to have headaches and his wife reports that he is a little off. I am sure about what I am saying as my tests show that the treatment I get not only helps slow down cancer growth, but also brings positive dynamics. Then, lastly, you can add something called zinc carnosine, which has been shown to help reflux. Be sure you understand all instructions that are specific to your use of Atrovent. Sunglasses have changed styles above the years Prescription glasses have also been graced with tints that one of the more appear as soon as the suns rays hit going to be the glasses. Levaquin side effects tendonitis - Answers on HealthTap ...
EndoZinâ„¢ has zinc carnosine complex with L-glutamine which helps protect the stomach and small intestine from injury while supporting gastric function and mucosal integrity
Confused about the difference between carnitine and carnosine? Not sure if vitamin K is actually a vitamin, or even real for that matter?
Gen-Tec Beta Alanine is a pure powder of the Carnosine booster. Youll be tingling head to toe with this powerful natural performance booster!
A study found that carnosine, a compound found in many recipes for chicken soup, can indeed mobilize the immune system to fight the early stages of the flu.