Food starches and dental caries. (1/43)
Sucrose and starches are the predominant dietary carbohydrates in modern societies. While the causal relationship between sucrose and dental caries development is indisputable, the relationship between food starch and dental caries continues to be debated and is the topic of this review. The current view of dental caries etiology suggests that in-depth evaluation of the starch-caries relationship requires the consideration of several critical cariogenic determinants: (1) the intensity (i.e., the amount and frequency) of exposure of tooth surfaces to both sugars and starches, (2) the bioavailability of the starches, (3) the nature of the microbial flora of dental plaque, (4) the pH-lowering capacity of dental plaque, and (5) the flow rate of saliva. Studies of caries in animals, human plaque pH response, and enamel/dentin demineralization leave no doubt that processed food starches in modern human diets possess a significant cariogenic potential. However, the available studies with humans do not provide unequivocal data on their actual cariogenicity. In this regard, we found it helpful to distinguish between two types of situations. The first, exemplified by our forebears, people in developing countries, and special subject groups in more modern countries, is characterized by starch consumption in combination with a low sugar intake, an eating frequency which is essentially limited to two or three meals per day, and a low-to-negligible caries activity. The second, exemplified by people in the more modern societies, e.g., urban populations, is characterized by starch consumption in combination with significantly increased sugar consumption, an eating frequency of three or more times per day, and a significantly elevated caries activity. It is in the first situation that food starches do not appear to be particularly caries-inducive. However, their contribution to caries development in the second situation is uncertain and requires further clarification. Although food starches do not appear to be particularly caries inducive in the first situation, the possibility cannot be excluded that they contribute significantly to caries activity in modern human populations. The commonly used term "dietary starch content" is misleading, since it represents a large array of single manufactured and processed foods of widely varying composition and potential cariogenicity. Hence, increased focus on the cariogenicity of single starchy foods is warranted. Other aspects of starchy foods consumption, deserving greater attention, include the bioavailability of starches in processed foods, their retentive properties, also in relation to sugars present (starches as co-cariogens), their consumption frequency, the effect of hyposalivation on their cariogenicity, and their impact on root caries. The starch-caries issue is a very complex problem, and much remains uncertain. More focused studies are needed. At present, it appears premature to consider or promote food starches in modern diets as safe for teeth. (+info)Modern methods for assessing the cariogenic and erosive potential of foods. (2/43)
Assessment of the acidogenic and cariogenic erosive potential of foods requires the use of reproducible and standardised methods. The methodology laid down at the San Antonio conference in 1985 remain today the basis for research on and the testing of foods. The 1999 workshop has updated the appropriate methodology and introduced guidelines on the testing of erosive potential of foods. It is to be hoped that researchers wishing to evaluate foods and their effect on the teeth will continue to use these methods. (+info)Intake of sweet foods and counts of cariogenic microorganisms in obese and normal-weight women. (3/43)
OBJECTIVE: To study the intake of sweet foods in obese and normal-weight women, while also taking menstrual cycle effects on eating behaviour into consideration. An objective test of the intake of sugar-containing foods was introduced by measuring salivary counts of mutans streptococci and lactobacilli. DESIGN: A cross-sectional comparison of the intake of sweet foods in obese and normal-weight women. The obese women were also studied longitudinally after 10 weeks in a weight reduction programme. SUBJECTS: Obese (n=72, body mass index (BMI) 42.0+/-5.2 kg/m2) and normal-weight women (n=67, BMI 22.2+/-1.6 kg/m2) participated. RESULTS: Mutans streptococci in saliva were higher in obese than in normal-weight women (P<0.0001), although the reported habitual daily intake of sweet foods did not differ. Of the menstruating women, 80% of the obese subjects and 62% of the normal-weight ones (P<0.05) reported periods during the menstrual cycle with an 'extra large' intake of sweet foods; these intakes were higher in obese than in normal-weight women (P<0.01). The obese women reduced their intake of sweet foods after 10 weeks of weight reduction, although these changes were not pronounced enough to significantly affect the counts of cariogenic microorganisms. CONCLUSIONS: In contrast to most previous cross-sectional studies, this study shows that obese women have a higher intake of sweet foods, especially pre-menstrually. This was indicated by higher salivary counts of cariogenic microorganisms. SPONSORSHIP: Karolinska Institute Research Funds. (+info)A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis. (4/43)
For more than 100 years, investigators have tried to identify the bacteria responsible for dental caries formation and to determine whether their role is one of specificity. Frequent association of Lactobacillus acidophilus and Streptococcus mutans with caries activity gave credence to their being specific cariogens. However, dental caries occurrence in their absence, and the presence of other bacteria able to produce substantial amounts of acid from fermentable carbohydrate, provided arguments for non-specificity. In the 1940s, Stephan found that the mixed bacteria in dental plaque produced a rapid drop in pH following a sugar rinse and a slow pH return toward baseline. This response became a cornerstone of plaque and mixed-bacterial involvement in dental caries causation when Stephan showed that the pH decrease was inversely and clearly related to caries activity. Detailed examination of the pH (acid-base) metabolisms of oral pure cultures, dental plaque, and salivary sediment identified the main bacteria and metabolic processes responsible for the pH metabolism of dental plaque. It was discovered that this metabolism in different individuals, in plaque in different dentition locations within individuals, and in individuals of different levels of caries activity could be described in terms of a relatively small number of acid-base metabolic processes. This led to an overall bacterial metabolic vector concept for dental plaque, and helped unravel the bacterial involvement in the degradation of the carbohydrate and nitrogenous substrates that produce the acids and alkali that affect the pH and favor and inhibit dental caries production, respectively. A central role of oral arginolytic and non-arginolytic acidogens in the production of the Stephan pH curve was discovered. The non-arginolytics could produce only the pH fall part of this curve, whereas the arginolytics could produce both the fall and the rise. The net result of the latter was a less acidic Stephan pH curve. Both kinds of bacteria are numerous in dental plaque. By varying their ratios, we were easily able to produce Stephan pH curves indicative of different levels of caries activity. This and substantial related metabolic and microbial data indicated that it is the proportions and numbers of acid-base-producing bacteria that are at the core of dental caries activity. The elimination of S. mutans, as with a vaccine, was considered to have little chance of success in preventing dental caries in humans, since, in most cases, this would simply make more room for one or more of the many acidogens remaining. An understanding of mixed-bacterial metabolism, knowledge of how to manipulate and work with mixed bacteria, and the use of a bacterial metabolic vector approach as described in this article have led to (1) a more ecological focus for dealing with dental caries, and (2) new means of developing and evaluating anti-caries agents directed toward microbial mixtures that counter excess acid accumulation and tooth demineralization. (+info)Do we need to be concerned about dental caries in the coming millennium? (5/43)
Dental caries continues to be a pubic health problem despite claims that 50% of schoolchildren are caries-free. There are widespread variations in the prevalence of caries worldwide. Caries lesions are the clinical manifestation of a pathogenic process that may have been occurring on the tooth surface for months or years. Acid production by bacteria embedded in a biofilm termed "dental plaque" is a key aspect of the pathogenesis of dental caries; nevertheless, the ability of micro-organisms to survive in a hostile acid milieu and the influence of fluoride and additional agents on this acid tolerance receive scant attention. Study of cariogenic micro-organisms largely has been limited to observations made on them in the planktonic state; clearly dental caries is essentially a surface phenomenon, and micro-organisms behave distinctively when grown on a surface. Although significant progress has been made in our understanding of the etiology, pathogenesis, and prevention of dental caries, it still remains a scientific and clinical enigma worthy of the attention of the best scientists. (+info)Effect of a Brazilian regional basic diet on the prevalence of caries in rats. (6/43)
The aim of the present study was to determine the effect of a regional basic diet (RBD) on the prevalence of caries in the molar teeth of rats of both sexes aged 23 days. The animals were divided into six groups of 10 rats each receiving the following diets for 30 and 60 days after weaning: RBD, a cariogenic diet, and a commercial diet. The prevalence and penetration of caries in the molar teeth of the rats was then analyzed. The RBD produced caries in 37.5% of the teeth of animals fed 30 days, and in 83.4% of animals fed 60 days, while the cariogenic diet produced caries in 72.5% and 77.5% of the teeth of animals fed 30 and 60 days, respectively. Rats fed the RBD for 30 days had caries in the enamel in 38% of their teeth, 48% had superficial dentin caries, and 7.5% moderate dentin caries. The effect of the RBD did not differ significantly from that of the cariogenic diet in terms of the presence of caries in rats fed 60 days. The penetration depth of the caries produced by the RBD was the same as that produced by the cariogenic diet. Our results show that the RBD has the same cariogenic potential as the cariogenic diet. Since the RBD is the only option for the low-income population, there should be a study of how to compensate for the cariogenicity of this diet. (+info)Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. (7/43)
Streptococcus mutans is the leading cause of dental caries (tooth decay) worldwide and is considered to be the most cariogenic of all of the oral streptococci. The genome of S. mutans UA159, a serotype c strain, has been completely sequenced and is composed of 2,030,936 base pairs. It contains 1,963 ORFs, 63% of which have been assigned putative functions. The genome analysis provides further insight into how S. mutans has adapted to surviving the oral environment through resource acquisition, defense against host factors, and use of gene products that maintain its niche against microbial competitors. S. mutans metabolizes a wide variety of carbohydrates via nonoxidative pathways, and all of these pathways have been identified, along with the associated transport systems whose genes account for almost 15% of the genome. Virulence genes associated with extracellular adherent glucan production, adhesins, acid tolerance, proteases, and putative hemolysins have been identified. Strain UA159 is naturally competent and contains all of the genes essential for competence and quorum sensing. Mobile genetic elements in the form of IS elements and transposons are prominent in the genome and include a previously uncharacterized conjugative transposon and a composite transposon containing genes for the synthesis of antibiotics of the gramicidin/bacitracin family; however, no bacteriophage genomes are present. (+info)Composition of dental plaque formed in the presence of sucrose and after its interruption. (8/43)
Since dental plaque reservoirs of fluoride (F), calcium (Ca) and inorganic phosphorus (Pi) are susceptible to decreases in pH, this in situ crossover study was conducted to test the hypothesis that the low concentration of these ions in plaque, formed in the presence of sucrose, could be attributed merely to the fermentation of this sugar. Eleven volunteers wore palatal appliances containing 6 human enamel blocks during two stages. In each stage, the treatments were either 20% sucrose solution or distilled deionized water, which were dripped onto the blocks 8 times a day. After 28 days, in each stage, the dental plaque formed on two blocks was collected, the treatment was inverted and after a further 24 and 48 h, the biofilm formed was collected from the other blocks. The concentration of acid-soluble F, Ca and Pi, and the concentration of insoluble polysaccharide (IP) were determined in the dental plaque. Statistically lower concentrations of F, Ca and Pi, and a higher concentration of IP were found in the 28-day biofilm formed in the presence of sucrose than in its absence; after the treatment inversion the change in F, Ca and Pi was not statistically significant, but the IP concentration changed significantly. The hypothesis was rejected because change in concentration of F, Ca and Pi is not due to fermentation of the sucrose. (+info)Cariogenic agents are microbial or chemical substances that contribute to the process of tooth decay by promoting the growth and activity of caries-causing bacteria, lowering oral pH, and increasing the production of acidic byproducts, which can dissolve tooth enamel and lead to dental caries.
Cariogenic agents are substances that contribute to the development of dental caries, or tooth decay. The primary culprit is typically oral bacteria, especially mutans streptococci, which metabolize sugars and produce acid as a byproduct. This acid can erode the enamel of teeth, leading to cavities. Other factors, such as certain dietary habits (e.g., frequent consumption of sugary or starchy foods) and poor oral hygiene, can also contribute to the cariogenic process.
3,3'-Diindolylmethane
6 June 2023). "3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm". ...
Plaque hypotheses
2006). "Correlation of cariogenic bacteria and dental caries in adults". Journal of Oral Science. 48 (4): 245-251. doi:10.2334/ ... Saliva containing more buffering agents such as calcium and phosphate ions alter the internal environment of dental plaque to ... No specific organisms had been identified at that point that were more cariogenic than others. Thus the amount of plaque in ... Despite this, the hypothesis was useful in diagnosis and treatment, associating caries with such truly cariogenic bacteria as ...
Dental composite
This results in a cariogenic biofilms at the interface of composite and tooth. The cariogenic activity of bacteria increases ... A coupling agent such as silane is used to enhance the bond between these two components.[citation needed] An initiator package ... Very high bond strengths to tooth structure, both enamel and dentin, can be achieved with dentin bonding agents. Tooth-sparing ... Researchers are highlighting the need for new composite materials to be developed which eliminate the cariogenic products ...
Hydroxyapatite
To prevent this, nano-hydroxyapatite can be added to the bleaching solution to reduce the impact of the bleaching agent by ... In the event of an acid attack by cariogenic bacteria, nano-hydroxyapatite particles can infiltrate pores on the tooth surface ... Teeth bleaching agents release reactive oxygen species which can degrade enamel. ... to reverse damage from carious assaults by either directly replacing deteriorated surface minerals or acting as a binding agent ...
Amine fluoride
The amine fluorides are thus available as an active agent for a longer period. Amine fluorides have a slightly acidic pH. For ... This acts as a fluoride depot over a longer period: Under cariogenic conditions fluoride ions are made available stimulating ... "Further Studies on the Influence of Surface Active Agents on Decalcification of the Enamel Surface". Journal of Dental Research ...
Biofilm
By preventing the dental plaque biofilm from maturing or by returning it back to a non-cariogenic state, dental caries can be ... Enzymes that degrade the biofilm matrix may be useful as anti-biofilm agents. Evidence has shown that a fatty acid messenger, ... GTAs, or gene transfer agents, are phage-like particles produced by the host bacteria and contain random DNA fragments from the ... Ciofu O, Tolker-Nielsen T (2019). "Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents-How P. ...
List of MeSH codes (D27)
... cariogenic agents MeSH D27.720.102.223 - cariostatic agents MeSH D27.720.102.339 - dental materials MeSH D27.720.102.583 - ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Menthol
It is oxidised to menthone by oxidising agents such as chromic acid or dichromate, though under some conditions the oxidation ... "Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review". ... Menthol is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and ... and more generally as a food flavor agent; such as in chewing gum and candy. In first aid products such as "mineral ice" to ...
Topical fluoride
... also serves as an antimicrobial agent to reduce demineralization by inhibiting the growth of tooth-erupting ... inhibiting the cariogenic microbial processes in dental plaque and increasing tooth resistance to acid breakdown. Fluoride has ... the inhibition of the cariogenic microbial metabolism in dental plaque and the increase of tooth resistance to acid dissolution ... while strontium chloride and potassium nitrate are added as anti-sensitive agents for individuals who have teeth sensitivity. ...
Streptococcus mutans
The causative agent of dental caries is associated with its ability to metabolize various sugars, form a robust biofilm, ... This therefore amplifies the cariogenic effect of S. mutans. Oral streptococci comprise both harmless and harmful bacteria. ... Surviving in the oral cavity, S. mutans is the primary causal agent and the pathogenic species responsible for dental caries ( ... ISBN 978-1-904455-24-0. Hoshino T, Fujiwara T, Kawabata S (2012). "Evolution of cariogenic character in Streptococcus mutans: ...
Enamel hypoplasia
Treatment with other topical agents, such as calcium phosphate (CPP-ACP), may also be effective in the remineralization of ... that the formation of pits and missing enamel provides a suitable local environment for adhesion and colonization of cariogenic ...
Glass ionomer cement
The influence of various conditioning agents on the interdiffusion zone and microleakage of a glass ionomer cement with a high ... suggestive that enough fluoride release may decrease the virulence of cariogenic biofilms. In addition, Ngo et al. (2006) ... they were mainly used for the restoration of abrasion/erosion lesions and as a luting agent for crown and bridge ... can determine whether the cement is used as luting agents, orthodontic bracket adhesives, pit and fissure sealants, liners and ...
Dental cement
They are usually used in conjunction with a bonding agent as they have no ability to bond to the tooth, although there are some ... Although classified as non-cariogenic by the Food and Drug Administration, eugenol is proven to be cytotoxic with the risk of ... Composition: Phosphoric acid liquid Zinc Oxide powder Formerly known as the most commonly used luting agent. Zinc Phosphate ... these etch the tooth surface and do not require an intermediate bonding agent Resin cements come in a range of shades to ...
Fluoride varnish
Use as a topical fluoride agent on moderate and high-risk patients, especially children aged 5 and younger Desensitizing agent ... Fluoride varnish treatments are shown to reduce the number of the cariogenic bacteria S. Mutans by over ten-fold. Fluoride ... They are recognised by the Food and Drug Administration for use as desensitising agents, but, currently, not as an anti-decay ... Chokshi, Krunal (2016). "An in vitro Comparative Evaluation of Three Remineralizing Agents using Confocal Microscopy". Journal ...
Asad Ullah Khan
Antimicrobial Agents and Chemotherapy. 60 (1): 356-360. doi:10.1128/AAC.01194-15. PMC 4704196. PMID 26525789. Khan, Shahper N; ... "A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic Streptococcus mutans". Biofouling ... Antimicrobial Agents and Chemotherapy. 52 (11): 4115-4120. doi:10.1128/AAC.00366-08. PMC 2573143. PMID 18725447. He, X (2003 ... Antimicrobial Agents and Chemotherapy. 53 (12): 5046-5054. doi:10.1128/aac.00774-09. ISSN 0066-4804. PMC 2786356. PMID 19770275 ...
Silver diammine fluoride
2009) compared the effectiveness of 38% against 12% SDF, with or without using a reducing agent for the caries arrest. Over a ... Similarly, the silver in SDF kills cariogenic bacteria by interacting with DNA and cellular proteins. This leads to cessation ... Savas S, Kucukyılmaz E, Celik EU, Ates M (2015). "Effects of different antibacterial agents on enamel in a biofilm caries model ... A new anti-caries agent". primary. Journal of Materials Science: Materials in Medicine. 25 (8): 2041-7. doi:10.1007/s10856-014- ...
Remineralisation of teeth
Fluoride varnishes were developed late 1960s and early 1970s and since then they have been used both as a preventative agent in ... Oral hygiene practices involve the mechanical removal of plaque from hard tissue surfaces Cariogenic bacteria levels in the ... "The Role of Remineralizing Agents in dentistry: A Review". Volume 32, Number 6. 2011. retrieved on 2016-05-22. Moynihan, Paula ... for enamel regeneration or as an oral care agent. It has a high affinity to tooth mineral. P11-4 is a self-assembling β-peptide ...
Lactoperoxidase
... is an effective antimicrobial agent and is used as an antibacterial agent in reducing bacterial microflora in ... Jyoti S, Shashikiran ND, Reddy VV (2009). "Effect of lactoperoxidase system containing toothpaste on cariogenic bacteria in ... Hence LPO is considered a very important defense against invasive bacteria and viral agents such as influenza and the SARS-CoV- ... ISBN 978-0-8247-7298-7. Rayman MP (November 2020). "Iodine and Selenium as Antiviral Agents: Potential Relevance to SARS-CoV-2 ...
List of sequenced bacterial genomes
2003). "The genome sequence of Clostridium tetani, the causative agent of tetanus disease". Proc. Natl. Acad. Sci. U.S.A. 100 ( ... 2002). "Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen". Proc. Natl. Acad. Sci. U.S.A. 99 (22): ... mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)". Genome Res. 14 (2): 221-7. doi: ... 2004). "The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae". ...
Tooth decay
However, cariogenic bacteria (the ones that can cause the disease) are present in dental plaque, but they are usually in too ... Low concentration fluoride ions act as bacteriostatic therapeutic agent and high concentration fluoride ions are bactericidal. ... Sucrose, although a bound glucose and fructose unit, is in fact more cariogenic than a mixture of equal parts of glucose and ... Over time, a mature biofilm is formed, creating a cariogenic environment on the tooth surface. The minerals in the hard tissues ...
Toothache
... such as the sedative agent used and whether a rubber dam was used. The success rate of root canal treatment also depends on the ... the majority of cases could be prevented by avoidance of a cariogenic diet and maintenance of good oral hygiene. That is, ...
3,3'-Diindolylmethane - Wikipedia
Production and characterization of a broad-spectrum antimicrobial 5-butyl-2-pyridine carboxylic acid from Aspergillus fumigatus...
Botelho, M. G. Fractional inhibitory concentration index of combinations of antibacterial agents against cariogenic organisms. ... Thanh, T. T., Quoc, T. N. & Xuan, H. L. Fusaric acid and derivatives as novel antimicrobial agents. Med. Chem. Res. 29(9), 1689 ... The calculated FIC index was used to detect the nature of the interaction between the two test agents and the interaction ... Barakat, K. M. & Yousry, M. G. Antimicrobial agents produced by marine Aspergillus tereus Var. Africanus against some virulent ...
Pharmaceutical Products Manufacturers & Suppliers in UAE
Non-cariogenic sweetener agent. *Anti-crystallizing agent. *Agent for bodying. Maltodextrins:. Maltodextrins can be obtained ... Agent to increase viscosity and also a crystallization inhibition in the formulations for liquids. ... Based on the purpose the starch can be used as a dissolving agent or binder. ... Due to their polymer nature, they also provide excellent binding agents to compress directly. ...
regular papers in refereed journals
416] J. Enax, M. Epple, Synthetic hydroxyapatite as a biomimetic oral care agent, Oral Health and Preventive Dentistry 16 ( ... 512] F. Meyer, J. Enax, M. Epple, B.T. Amaechi, B. Simader, Cariogenic biofilms: development, properties, and biomimetic ... 367] B. Neuhaus, B. Tosun, O. Rotan, A. Frede, A.M. Westendorf, M. Epple, Nanoparticles as transfection agents: a ... 277b] S. Chernousova, M. Epple, Silver as antibacterial agent: Ion, nanoparticle, and metal, Angewandte Chemie International ...
Department of Comprehensive Dentistry - Publications
- Scholars @ UT Health San Antonio
Cariogenic biofilms: Development, properties, and biomimetic preventive agents. Meyer, F., Enax, J., Epple, M., Amaechi, B. T. ... Hydroxyapatite as Remineralization Agent for Childrens Dental Care. Meyer, F., Enax, J., Amaechi, B. T., Limeback, H., ... In vitro effect of an oral spray and mouthrinses on dual species cariogenic bacteria biofilm. Azees, P. A. A., Wang, H., Chen, ...
Use of Minimally Invasive Techniques and Antimicrobial Agents to Treat Rampant Caries - Dentistry Today
The process starts when the QASi particles electrostatically attract cariogenic pathogens. When the bacteria come into contact ... Use of Minimally Invasive Techniques and Antimicrobial Agents to Treat Rampant Caries Written by: Dr. Yuval Wind February 13, ... QASi is incorporated into both the universal composite and a dentin bonding agent. The QASi particles are insoluble and non- ...
Animal models - lookformedical.com
Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. | J....
Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of...
The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans. Antimicrob Agents ... moorei is considered as a key causative agent of halitosis [22-25]. In addition, it has also been associated with various types ... The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease. ...
Antimicrobial efficacy of commercially available mouthrinses: An in vitro study Mruthyuenjaya RK, Venugopal S, Sateesh CP,...
The ideal condition is removing the most cariogenic and periodontopathic agents from dental plaque.[1],[2] Dental plaque ... Various types of chemotherapeutic agents are coming up with different antimicrobial agents in them. Hence, this study has been ... It has been established that S. mutans is the leading cause of dental caries and is considered to be the most cariogenic of all ... Keywords: Antimicrobial activity, antimicrobial agents, chlorhexidine gluconate, mouthrinse. How to cite this article:. ...
Research Day Poster Presentations 2019 - UW School of Dentistry
Silver diammine fluoride (SDF) is an increasingly popular anti-cariogenic agent for minimally-invasive dentistry. This study ... However, pre-clinical studies in mice, rats, and monkeys have repeatedly demonstrated that exposure to anesthetic agents during ... Early characterization and acidogenicity assessment of oral biofilms may facilitate management of cariogenic oral biofilms. The ...
Minding the tooth gap | Swedish Organization for Global Health
Features of the molecular composition of dental biofilm in patients depending on the degree of caries and the method of its...
Meyer F., Enax J., Epple M., Amaechi B.T., Simader B. Cariogenic biofilms: development, properties, and biomimetic preventive ... saliva and preventive agents in enamel demineralization and remineralization. The Journal of the American Dental Association. ... as well as the difference in the microbiota caused by the impact of preventive agents on biofilm ... The FT-IR and Raman spectroscopies as tools for biofilm characterization created by cariogenic streptococci. International ...
Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms. | Eur J Oral Sci;127(2): 122-129, 2019 04. |...
Effect of different 1% chlorhexidine varnish regimens on biochemical composition of the dental biofilm
... dental caries in patients with high levels of cariogenic microorganisms is their suppression by chemotherapeutic agents (1-3). ... The presence of MS in dental biofilm has been used as an indicator of cariogenic biofilm (4,5). Studies that evaluated CHX have ... Effects of a 1% chlorhexidine gel on the cariogenic bacteria in high-risk elders: a pilot study. Spec Care Dentist 1991;11:101- ... Ekenback SB, Linder LE, Lonnies H. Effect of four dental varnishes on the colonization of cariogenic bacteria on exposed sound ...
THE BIOCHEMICAL ANALYSIS OF SALIVARY ORGANIC COMPOUNDS TO PATIENTS SUFFERING FROM CARIES DISEASE - Romanian Journal of Oral...
medical science - Does Milk Protect or Harm Your Teeth? - Skeptics Stack Exchange
Milk has cariostatic agents eg. casein proteins, calcium phosphates. However milk can be cariogenic if it remains in contact ... How can we fix it? (Likes to the definitions of cariostatic and cariogenic would be a start.) - Oddthinking ♦ ... 86], using a similar system, showed that milk (with 3 levels of fat content) was not cariogenic for enamel or dentine. Gedalia ... A severe test of the cariogenic or cariostatic properties of milk was developed by Bowen et al. [68, 69], using desalivated ...
Polymers (medical concept explorer)
Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: new...
... a promising antimicrobial agent against the cariogenic bacterium Streptococcus mutans. Nanomaterials. 2016;6:179. ... This is in agreement with the notion that bacteria from biofilms are more resistant to antibacterial agents than their ... Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 2001;9:34-9. ... frequently found in wall paintings as biodeteriorative agents. In particular, strains of Staphylococcus aureus and Pseudomonas ...
Benoit receives NIH funding for project: "A novel anti-caries approach to modulate virulence of cariogenic biofilms" : News &...
We demonstrated that these agents in combination severely compromise EPS-matrix assembly and cariogenic biofilm development, ... We will focus on increasing the kinetics of NPC pH-responsive drug release to ensure maximal release of the agents at pH ... Aim 3 will evaluate the efficacy of the developed CT-NPC in disrupting cariogenic biofilms and reducing dental caries in vivo ... In addition, retention of these agents at tooth-biofilm interface could be enhanced to maximize their efficacy in vivo. To ...
Staphylococcus aureus | Find Me A Cure
... a potential phytochemical agent for the prevention of dental caries by inhibiting the growth of cariogenic bacteria.. • Anti- ... Another report says that it is an active antitumour agent but is too toxic for clinical use. Another report says that ... Bidwillon B presents as a potent phytotherapeutic and/or combination agent with mupirocin in the elimination of nasal and skin ... Mucolytic agent, October, Old English, Perennial plant, Plant, Seed, Staphylococcus, Staphylococcus aureus, University of ...
DeCS
The influence of resin-based dental materials on oral biofilms developement
The lowest values of cariogenic biofilm were reached by less hydrophobic resin and by nanofillers. The third approach evaluated ... without the need for specifically biocidal agents. Resin-functionalized nanoparticles of dicalcium phosphate dihydrate (nDCPD) ... of these materials were evaluated as a possible effective way to control biofilm formation without the need for biocidal agents ... The lowest values of cariogenic biofilm were reached by less hydrophobic resin and by nanofillers. The third approach evaluated ...
IJMS | Free Full-Text | Bioactivities of Phenolics by Focusing on Suppression of Chronic Diseases: A Review
Antibacterial and anti-viral agents kill or slow down the action of bacteria and viruses without inflicting any damage to the ... 43] reported that gallic acid and its derivatives attenuate the growth of cariogenic and periodontopathic bacteria. Gallic acid ... In this connection, phenolics have also been shown to be potent antibacterial and anti-viral agents. For instance, phenolics ... García-Lafuente, A.; Guillamón, E.; Villares, A.; Rostagno, M.A.; Martínez, J.A. Flavonoids as anti-inflammatory agents: ...
Honey! Natural Treatment for Gum Disease
The protective agent in honey appears to be an organic phosphate ester of some sort (Edgar and Jenkins 1974). . Prolonged ... In another two, honey was found to be more cariogenic than sucrose was (König 1967; Wakeman et al. 1948). . But another study ... Solubility-reducing agents in honey and partly-refined crystalline sugar. British Dental Journal 136 (7):7-14.. ... Although there has been some recognition of this in the past in regard to the question of whether or not honey is cariogenic, ...
A COMAPARATIVE STUDY OF THE CLINICAL EFFICIENCY OF A CHEMO MECHANICAL AGENT, BRIX- 3000, ROUND BUR FOR CARIES REMOVAL. AN IN...
Efficacy of chemomechanical caries removal in reducing cariogenic microbiota: a randomized clinical trial. 2014. Braz Oral Res ... Dhamija N, Pundir P. A Review on Agents for Chemomechanical Caries Removal. Sch J Dent Sci J Dent Sci. 2016;3(9):264-268. [ ... Singh S., Singh D.J., Jaidka S., Somani R.. Comparative clinical evaluation of chemomechanical caries removal agent Papacarie® ... A COMAPARATIVE STUDY OF THE CLINICAL EFFICIENCY OF A CHEMO MECHANICAL AGENT, BRIX- 3000, ROUND BUR FOR CARIES REMOVAL. AN IN ...
BacteriaStreptococcusBiofilmsFluorideAntibacterial agentDietBiofilm modelTooth enamelVirulencePlaqueVitroSweetenerBacterialSeverelyMeSHSucroseCausative agentPotentialClinicalPhysicochemicalSystemicTherapeutic agentsPreventiveOralVivoEnamelInfectiousTermsMajorMedicinalCommonlyExtractControlDevelopmentNaturalSeveral agentsSolutionsAnti-crystAddition
Bacteria16
- There are several risk factors that contribute to the manifestation of tooth decay such as a high component of cariogenic bacteria, inadequate salivary flow, reduced exposure to fluoride, poor or incorrect oral hygiene, incorrect methods of feeding newborns, and poverty [ 4 ]. (hindawi.com)
- 16. Caesalpinia sappan: A promising natural source of antimicrobial agent for inhibition of cariogenic bacteria. (nih.gov)
- The silver acts as an antimicrobial agent against cariogenic bacteria and the fluoride works to help prevent further demineralization of the tooth. (colgateprofessional.com)
- Sodium hypochlorite (NaOCl) is a highly active cytotoxic oxidant recognized to be among the most potent antiseptic and disinfectant agents against bacteria, fungi, and viruses. (medscape.com)
- As antimicrobial agents, green tea catechins can destroy cariogenic (cavity-causing) bacteria. (purenaturenutrition.com)
- Research shows that green tea catechins not only suppress the formation of plaque by cariogenic bacteria but also kill the bacteria themselves. (purenaturenutrition.com)
- Moreover, the latest research indicated that cariogenic bacteria may severely influence the course of SARS-CoV-2 infection and increase risk of COVID-19 complications. (bvsalud.org)
- Moreover, a diet rich in polyphenols prevents cariogenic bacteria and reduces the accumulation of dental plaque. (bvsalud.org)
- The results suggest that the clove oil and eugenol could be employed as a natural antibacterial agent against cariogenic and periodontopathogenic bacteria. (campwander.com)
- Furthermore, EPS-embedded bacteria also create highly protected and acidic microenvironments that promote cariogenic biofilm build-up and acid-dissolution of tooth enamel. (rochester.edu)
- Cavity disinfection using antibacterial agents before cavity restoration ensures to a great extent elimination of cariogenic bacteria in the residual dental tissues and a long term restoration success. (researchsquare.com)
- Reductions of cariogenic bacteria in mothers for the purpose of interfering or delaying transmission to the child has been shown to reduce both transmission and caries in children. (dentistryiq.com)
- Streptococcus mutans , a commensal bacteria of the oral microflora, is the primary etiological agent strongly linked to dental caries. (informaticsjournals.com)
- It is characterized by the demineralization of tooth enamel caused by acid produced by cariogenic dental bacteria growing on tooth surfaces, termed bacterial biofilms. (tmc.edu)
- One of the factors of dental caries etiology is cariogenic bacteria known as Lactobacillus acidophilus . (nstproceeding.com)
- Contains Xylitol, a sugar-free sweetener, known to reduce the number of cariogenic bacteria in the plaque, and to decrease the amount of insoluble plaque polysaccharides, making the plaque less adhesive and easier to remove through brushing. (swident.com)
Streptococcus3
- [ 6 ] Of potentially great clinical significance, povidone-iodine can kill the major cariogenic bacterium Streptococcus mutans , and caries-prone children who received a povidone-iodine application to their entire dentition every 2-3 months experienced a marked reduction in new caries lesions compared with control children. (medscape.com)
- 2021-03-04 · Cariogenic Streptococcus mutans is known as a predominant etiological agent of dental caries due to its exceptional capacity to form biofilms. (netlify.app)
- Klein MI, Hwang G, Santos PH, Campanella OH, Koo H. Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. (informaticsjournals.com)
Biofilms3
- The development of novel chemotherapeutic approaches against cariogenic biofilms is challenging. (rochester.edu)
- Aim 3 will evaluate the efficacy of the developed CT-NPC in disrupting cariogenic biofilms and reducing dental caries in vivo using a rodent model of dental caries under clinically-relevant topical treatment regimen. (rochester.edu)
- Four types of analysis were performed: 1) fluorescence microscopy of biofilms stained with Syto 9 and hexidium idodine to determine the biofilm architecture, 2) quantitative PCR (qPCR) to determine the cell number of each species per cm2, 3) vertical scanning interferometry (VSI) to determine the cariogenic potential of the biofilms, and 4) tomographic pH imaging using radiometric fluorescence microscopy after exposure to pH sensitive nanoparticles to measure the micro-environmental pH. (tmc.edu)
Fluoride12
- Sodium fluoride was the most commonly used caries preventive agent. (bvsalud.org)
- Meta-analysis showed no significant difference between sodium fluoride formulations and other fluoride agents. (bvsalud.org)
- Fluoride treatment when incorporated with re-mineralising agent had no significant effect on caries prevention CONCLUSION: Fluoride prevents radiation caries. (bvsalud.org)
- To overcome these remarkable challenges, our previous NIH supported (DE018023) studies developed a potent anti-caries approach by combining food-derived antibiofilm agents (myricetin and farnesol) with fluoride. (rochester.edu)
- We hypothesize that NPC will substantially amplify the efficacy of our combination therapy (CT) via increased solubility, retention and pH-activated release of active agents with fluoride. (rochester.edu)
- Then, Aim 2 will evaluate the efficacy of optimized NPCs containing Myr and Far with fluoride (CT-NPC) using our in vitro cariogenic biofilm model. (rochester.edu)
- In the last issue, we discussed several remineralizing agents, but did not review fluoride. (dentistryiq.com)
- The principal mode of action of fluoride, and the other remineralizing agents, is to increase the resistance of enamel to demineralization and to promote remineralization. (dentistryiq.com)
- Fluoride is a proven anti-caries agent, used in toothpaste to strengthen the tooth enamel and protect against demineralization. (com.bo)
- Fluoride is the only anti-caries agent accepted by the Food and Drug Administration (FDA). (com.bo)
- Used as a desensitizing agent in products like Colgate Gel-Kam , stannous fluoride works by occluding the dentinal tubules with a tin-rich deposit, thereby preventing the fluid movement within the dentinal tubules that is associated with pain from sensitivity. (com.bo)
- Among the most common anti-plaque, anti-gingivitis agents are stannous fluoride and zinc citrate, both of which help to reduce biofilm and have a proven anti-gingivitis effect. (com.bo)
Antibacterial agent1
- AKBA can be useful compound for the development of antibacterial agent against oral pathogens and it has great potential for use in mouthwash for preventing and treating oral infections. (biomedcentral.com)
Diet1
- However, this delicate balance is often skewed towards demineralization with poor oral hygiene and a cariogenic diet. (nih.gov)
Biofilm model1
- The qualitative and quantitative results reveal the expected dynamics of the community profile when exposed to different sucrose conditions and the cariogenic potential of this in vitro four-species anaerobic biofilm model, thus confirming its usefulness for future analysis of primary and secondary dental caries. (tmc.edu)
Tooth enamel1
- When tooth enamel is attacked by cariogenic acids, teeth become porous, and white spot lesions appear. (dradampollockdds.com)
Virulence1
- Many of these ecological approaches aim for long-term caries control by either disrupting cariogenic virulence factors without affecting bacterial viability, or include measures that can enhance the growth of health-associated, microbially diverse communities in the oral microbiome. (karger.com)
Plaque5
- Dental caries or tooth decay is a prevalent global disease whose causative agent is the oral biofilm known as plaque. (whiterose.ac.uk)
- It showed that propolis could be a useful agent in decreasing the accumulation of dental plaque. (bvsalud.org)
- The rationale for use of chemotherapeutic agents for the control or prevention of dental caries dictates a more holistic understanding of the plaque microcommunity. (dentistryiq.com)
- Chemotherapeutic approaches must be better targeted against specific microbes with the goal of re-establishing an ecologically stable non-cariogenic plaque. (dentistryiq.com)
- The current research targeting microbial biofilm inhibition has attracted a great deal of attention, and the search for effective antimicrobial agents against these oral pathogens could lead to identification of new agents for the prevention of dental caries and periodontal diseases arising out of dental plaque formation [ 6 ]. (biomedcentral.com)
Vitro2
- To evaluate in vitro the effect of a red propolis ethanolic extract (RPE) in the prevention of growth of a cariogenic biofilm and its cytotoxic potential. (bvsalud.org)
- Excitingly, NPC respond to acidic pH to release agents more rapidly at acidic (pathological) versus neutral (physiological) pH, greatly improving (~20-fold more effective than free agents) antibiofilm activity in vitro. (rochester.edu)
Sweetener1
- Ingredient Specialties, Inc. introduces Züeit® brand Sucralose, a non-caloric, non-cariogenic, high intensity sweetener made from sugar. (garudaint.com)
Bacterial3
- Here we employ agent-based mathematical modelling to simulate a biofilm consisting of two competing, distinct types of bacterial populations, each parameterised by their nutrient uptake and aciduricity, periodically subjected to an acid challenge resulting from the metabolism of dietary carbohydrates. (whiterose.ac.uk)
- As dental caries with its bacterial agents is an infectious disease, and shows a vertical transmission, the control of bacterial transmission of Mutans streptococci (MS) from mother to child is desirable. (dentistryiq.com)
- Neem: Neem is known as one of the strongest anti-bacterial agents and is used for dental care. (ayurvedant.com)
Severely1
- We demonstrated that these agents in combination severely compromise EPS-matrix assembly and cariogenic biofilm development, resulting in a highly effective anti-caries therapy in vivo. (rochester.edu)
MeSH1
- Cariogenic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Sucrose1
- EN] This article analyses, the replacement of sucrose in muffins with nine different combinations of isomaltulose and oligofructose. (upv.es)
Causative agent1
- Cariogenesis is a complex biological process that is influence by multiple factors and is not attributed to a sole causative agent. (tmc.edu)
Potential2
- The anti-histaminic medicines evaluated have a high erosive and cariogenic potential, as they present low pH and a high total soluble solids content. (bvsalud.org)
- The review aims to explain the cariogenic antibacterial potential of Stevia rebaudiana Bertoni leaves extract against Lactobacillus acidophilus . (nstproceeding.com)
Clinical2
- Chemotherapy of viral infections is difficult because of the timing of events of the disease process versus appearance of clinical symptoms and lack of effective agents with selective toxicity. (nih.gov)
- Clinical trials with long‑term follow‑up demonstrated cariogenic microorganisms persist under restorations and have an important role in the development of secondary caries. (researchsquare.com)
Physicochemical1
- To support our hypothesis, Aim 1 will optimize physicochemical properties of NPC to improve targeted delivery of our agents, and thereby potentiate their antibiofilm efficacy. (rochester.edu)
Systemic2
- Moreover, because the contents of inflamed periodontal pockets are emptied into the oral cavity every 90 seconds, and relatively small amounts of antimicrobial agents are applied subgingivally, the risk for antiseptics entering the gingival tissue and causing systemic damage is virtually nonexistent. (medscape.com)
- Ketoconazole, an orally active systemic antifungal agent, may be used for monilial infections of the oral cavity refractory to nystatin. (nih.gov)
Therapeutic agents2
- The National Institute of Dental and Craniofacial Research (NIDCR) invites the small business community to apply cutting edge-technology to the design and development of novel delivery systems for rapid and/or sustained, on-demand release of therapeutic agents (e.g. antimicrobial, anti-inflammatory, antibodies, peptides, nucleotides, small molecule receptor agonists/antagonists) in the oral cavity. (nih.gov)
- As propolis mouth rinses and propolis-based toothpastes stop the growth of pathogens of gingivitis and periodontitis, they seem to be promising not only as preventive but also as therapeutic agents [30, 45, 48, 49]. (stackexchange.com)
Preventive1
- Application of the DMFT index in epidemiologic surveys throughout the United States in the 1930s and 1940s allowed quantitative distinctions in dental caries experience among communities--an innovation that proved critical in identifying a preventive agent and evaluating its effects. (cdc.gov)
Oral2
- Nystatin remains a first-choice agent for treatment of oral candidal infections. (nih.gov)
- The aromatic molecules derived from natural sources are being explored extensively as alternative agents in oral care products. (biomedcentral.com)
Vivo1
- In addition, retention of these agents at tooth-biofilm interface could be enhanced to maximize their efficacy in vivo. (rochester.edu)
Enamel2
- After years of personal field investigations, McKay concluded that an agent in the public water supply probably was responsible for mottled enamel. (cdc.gov)
- The identification of a possible etiologic agent for mottled enamel led to the establishment in 1931 of the Dental Hygiene Unit at the National Institute of Health headed by Dr. H. Trendley Dean. (cdc.gov)
Infectious1
- [ 4 ] Antiseptics attack multiple components of infectious agents, practically eliminating the risk for development of resistance, and do not interact with prescription medications. (medscape.com)
Terms1
- In a sub-group analysis in this same study they found that in cariogenic shock, Noradrenaline was superior to dopamine in terms of reduction in mortality. (resus.com.au)
Major1
- This graph shows the total number of publications written about "Cariogenic Agents" by people in this website by year, and whether "Cariogenic Agents" was a major or minor topic of these publications. (ucdenver.edu)
Medicinal2
- With therapeutic purpose, sick cats (two groups of 8 animals/group) were administered: anti-microbial agent (5% solution of Enrofloxacin), spasmolytic medicinal agent - RiabalReg. (cranberryinstitute.org)
- Bartzatt, R. Central Nervous System Agents in Medicinal Chemistry, 2012. (nih.gov)
Commonly1
- Potassium nitrate, as found in the Colgate Sensitive range, is another commonly used desensitizing agent. (com.bo)
Extract2
- Orange slices have been osmotically dehydrated using as osmotic agents new healthy sweeteners: isomaltulose, oligofructose and aqueous extract of stevia. (upv.es)
- Lemon slices were osmotically dehydrated using the following healthy sweeteners as osmotic agents: tagatose, isomaltulose, oligofructose and aqueous extract of stevia. (upv.es)
Control2
- ES] A pesar del placer asociado al consumo de golosinas, los problemas de caries, sobrepeso y aumento de glucosa en sangre asociadas a las mismas implican un control en su ingesta. (upv.es)
- Ahora que la COVID-19 ha resaltado la importancia del control de infecciones en los consultorios dentales, hablaremos acerca del papel de los enjuagues bucales antes del procedimiento para reducir las cargas virales y bacterianas. (com.bo)
Development1
- Ascorbic acid, one of the chief components of C. limon fruit, is a promising agent for the development of anti-caries products. (informaticsjournals.com)
Natural1
- Mannitol is a natural sweetner and can be used as an anti-cakeing agent. (thatplacesmokeshop.com)
Several agents1
- Fermentable sugar, host factors, and cariogenic microbial flora are several agents that influence dental structure. (hindawi.com)
Solutions1
- Iodophors (iodine-releasing agents) developed in the 1950s were solutions of iodine complexed with an organic carrier that largely overcame the negative aspects of iodine treatment. (medscape.com)
Anti-cryst1
- Is an excellent moisturising, texturizing and anti-crystallising agent. (zukan.es)
Addition1
- In addition to providing sweetness, it is an excellent humectant and texturizing agent. (ambujagroup.com)
