Cardiovirus: A genus of the family PICORNAVIRIDAE causing encephalitis and myocarditis in rodents. ENCEPHALOMYOCARDITIS VIRUS is the type species.Cardiovirus Infections: Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.Mengovirus: A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, isolated from rodents and lagomorphs and occasionally causing febrile illness in man.Encephalomyocarditis virus: The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.Picornaviridae: A family of small RNA viruses comprising some important pathogens of humans and animals. Transmission usually occurs mechanically. There are nine genera: APHTHOVIRUS; CARDIOVIRUS; ENTEROVIRUS; ERBOVIRUS; HEPATOVIRUS; KOBUVIRUS; PARECHOVIRUS; RHINOVIRUS; and TESCHOVIRUS.Theilovirus: A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.Maus Elberfeld virus: A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.Mosaic Viruses: Viruses which produce a mottled appearance of the leaves of plants.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Badnavirus: A genus of DNA plant viruses with bacilliform morphology. Transmission in clonally-propagated plants is by vegetative propagation of infected plant materials. Transmission in nature is by mealybugs, seeds, and pollen. The type species is Commelina yellow mottle virus.Tungrovirus: A genus of DNA plant viruses of the family CAULIMOVIRIDAE. The sole species, Rice tungro bacilliform virus, shows 25% identity with BADNAVIRUS. It is transmitted by leafhoppers with the assistance of RICE TUNGRO SPHERICAL VIRUS.Cesium: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Genetics, Medical: A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Health Policy: Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Pragmatic Clinical Trials as Topic: Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Cardiac Care Facilities: Institutions specializing in the care of patients with heart disorders.Cardiac Surgical Procedures: Surgery performed on the heart.Faculty: The teaching staff and members of the administrative staff having academic rank in an educational institution.Students: Individuals enrolled in a school or formal educational program.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.National Academy of Sciences (U.S.): A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.Electric Countershock: An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Atrial Flutter: Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Calcaneus: The largest of the TARSAL BONES which is situated at the lower and back part of the FOOT, forming the HEEL.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.ConjunctivitisEthiopia: An independent state in eastern Africa. Ethiopia is located in the Horn of Africa and is bordered on the north and northeast by Eritrea, on the east by Djibouti and Somalia, on the south by Kenya, and on the west and southwest by Sudan. Its capital is Addis Ababa.Webcasts as Topic: Transmission of live or pre-recorded audio or video content via connection or download from the INTERNET.Integrated Advanced Information Management Systems: A concept, developed in 1983 under the aegis of and supported by the National Library of Medicine under the name of Integrated Academic Information Management Systems, to provide professionals in academic health sciences centers and health sciences institutions with convenient access to an integrated and comprehensive network of knowledge. It addresses a wide cross-section of users from administrators and faculty to students and clinicians and has applications to planning, clinical and managerial decision-making, teaching, and research. It provides access to various types of clinical, management, educational, etc., databases, as well as to research and bibliographic databases. In August 1992 the name was changed from Integrated Academic Information Management Systems to Integrated Advanced Information Management Systems to reflect use beyond the academic milieu.Netherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Nobel PrizeEnterovirus InfectionsCarcinoma, Krebs 2Histiocytic Necrotizing Lymphadenitis: Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.

Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. (1/262)

Theiler's murine encephalomyelitis viruses are picornaviruses that can infect the central nervous system. The DA strain produces an acute polioencephalomyelitis followed by a chronic demyelinating disease in its natural host, the mouse. The ability of DA virus to induce a demyelinating disease renders this virus infection a model for human demyelinating diseases such as multiple sclerosis. Here we describe the generation and characterization of DA virus mutants that contain specific mutations in the viral capsid protein VP1 at sites believed to be important contact regions for the cellular receptor(s). A mutant virus with a threonine-to-aspartate (T81D) substitution in VP1 loop I adjacent to the putative virus receptor binding site exhibited a large-plaque phenotype but had a slower replication cycle in vitro. When this mutant virus was injected into susceptible mice, an altered tropism was seen during the acute stage of the disease and the chronic demyelinating disease was not produced. A virus with a threonine-to-valine substitution (T81V) did not cause any changes in the pattern or extent of disease seen in mice, whereas a virus with a tryptophan substitution at this position (T81W) produced a similar acute disease but was attenuated for the development of the chronic disease. A change in amino acids in a hydrophobic patch located in the wall of the pit, VP1 position 91, to a hydrophilic threonine (V91T) resulted in a profound attenuation of the acute and chronic disease without persistence of virus. This report illustrates the importance of the loop I of VP1 and a site in the wall of the pit in pathogenesis and that amino acid substitutions at these sites result in altered virus-host interactions.  (+info)

Differentiation of M1 myeloid precursor cells into macrophages results in binding and infection by Theiler's murine encephalomyelitis virus and apoptosis. (2/262)

Infection of susceptible mouse strains with BeAn, a less virulent strain of Theiler's murine encephalomyelitis virus (TMEV), results in immune system-mediated demyelinating lesions in the central nervous system (CNS) similar to those in multiple sclerosis. Since macrophages appear to carry the major detectable antigen burden in vivo, and purification of sufficient cell numbers from the CNS for detailed analysis is difficult, macrophage-like cell lines provide an accessible system with which to study virus-macrophage interactions. The myeloid precursor cell line M1 differentiates in response to cytokines and expresses many characteristics of tissue macrophages. Incubation of TMEV with undifferentiated M1 cells produced neither infection nor apoptosis, whereas differentiated M1 (M1-D) cells developed a restricted virus infection and changes indicative of apoptosis. Virus binding and RNA replication as well as cellular production of alpha/beta interferons increased with differentiation. Although the amount of infectious virus was highly restricted, BeAn-infected M1-D cells synthesized and appropriately processed virus capsid proteins at levels comparable to those for permissive BHK-21 cells. Analysis of Bcl-2 protein family expression in undifferentiated and differentiated cells suggests that susceptibility of M1-D cells to apoptosis may be controlled, in part, by expression of the proapoptotic alpha isoform of Bax and Bak. These data suggest that macrophage differentiation plays a role in susceptibility to TMEV infection and apoptosis.  (+info)

Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. (3/262)

OBJECTIVES: This study was designed to examine the effects of pimobendan in a murine model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide (NO) synthesis by inducible NO synthase (iNOS) in the heart. BACKGROUND: Pimobendan has been recently confirmed to improve both acute and chronic heart failure. Since the modulation of myocardial necrosis and contractile dysfunction by various proinflammatory cytokines may be partially mediated by the production of nitric oxide, the effects of pimobendan on the production ofproinflammatory cytokines and NO were investigated in an animal model of viral myocarditis involving heart failure. METHODS: DBA/2 mice were inoculated with the encephalomyocarditis virus. To observe its effect on survival up to 14 days, pimobendan (0.1 mg/kg or 1 mg/kg) or vehicles were given from the day of virus inoculation (day 0) orally once daily. The effects of pimobendan on histological changes, cytokine production, NO production and iNOS gene expression in the heart were studied in mice treated either with pimobendan, 1 mg/kg or with vehicles only, and sacrificed seven days after virus inoculation. RESULTS: The survival of mice improved in a dose-dependent fashion such that a significant difference (p < 0.02) was found between the higher-dose pimobendan group (20 of 30 [66.7%]) and the control group (11 of 30 [36.7%]). Histological scores for cellular infiltration (1.1+/-0.1 vs. 2.0+/-0.0, p < 0.001), intracardiac tumor necrosis factor (TNF)-alpha (18.2+/-1.8 vs. 35.8+/-4.2 pg/mg heart, p < 0.001) and interleukin (IL)-1beta (9.3 +/-1.2 vs. 26.6+/-7.1 pg/mg heart, p < 0.01) were significantly lower in the mice given pimobendan versus those of the control mice. Interleukin-6 levels (7.1+/-0.8 vs. 9.2+/-1.9 pg/mg heart) were also lower in the mice treated with pimobendan. Furthermore, intracardiac NO production was significantly (p < 0.001) less in the pimobendan group (0.165+/-0.004 nmol/mg heart) than in the control group (0.291+/-0.051 nmol/mg heart), and intracardiac iNOS gene expression in the mice given pimobendan was 74% lower than it was in the control animals (p < 0.01). CONCLUSIONS: These findings suggest that the beneficial effects of pimobendan in viral myocarditis are partially mediated by the inhibition of both proinflammatory cytokine production and NO synthesis by iNOS.  (+info)

Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (4/262)

Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on cardiovascular development and disease, transgenic mice were created in which the mouse preproendothelin-1 promoter was used to target elafin overexpression to the cardiovascular system. To distinguish the transgene from endogenous elafin, constructs were made incorporating a FLAG sequence; the COOH-terminus FLAG-tagged elafin construct produced a stable, functionally active gene product and was used to create transgenic mice. Consistent with endothelin expression, abundant elafin mRNA was observed in transgenic F1 embryos (embryonic day 13.5) and in adult transgenic mice heart, trachea, aorta, kidney, lung, and skin, but not in liver, spleen, and intestine. Functional activity of the transgene was confirmed by heightened myocardial elastase inhibitory activity. No tissue abnormalities were detected by light microscopy or elastin content. However, injection of 10 plaque-forming units (PFU) of encephalomyocarditis virus resulted in death within 11 days in 10 out of 12 nontransgenic mice compared with one out of nine transgenic littermates. This reduced mortality was associated with better cardiac function and less myocardial inflammatory damage. Thus, elafin expression may confer a protective advantage in myocarditis and other inflammatory diseases.  (+info)

Encephalomyocarditis (EMC) virus infection in PC12 and C6 cells. (5/262)

PC12 cells derived rom rat pheochromocytoma and C6 cells derived from rat glioma were infected with 0.3 plaque forming units (PFU)/cell of the D variant of encephalomyocarditis virus (EMC-D), after pretreatment with or without nerve growth factor (NGF). The virus titres in medium and cells were investigated at 6, 12, 24, 48 and 72 h post infection (HPI), and histopathology and viral antigens in cells were examined at 24 and 48 HPI, respectively. As a result, neither viral replication nor light and electron microscopic changes were observed in PC12 cell cultures without NGF-pretreatment. On the contrary, in PC12 cell cultures with NGF-pretreatment, the virus titre prominently increased at 12 HPI, and peaked at 48 HPI. In addition, distinct histological and ultrastructural changes with viral antigens in cells were observed. C6 cells showed similar morphology and susceptibility to EMC-D-infection irrespective of NGF-pretreatment. Namely, the virus titres in C6 cell cultures increased slightly and viral antigens were found in a small number of C6 cells, but there were no evident histological and ultrastructural changes. These results suggest that PC12 cells pretreated with NGF and C6 cells are susceptible to EMC-D infection in vitro.  (+info)

Interstitial fibrin-fibronectin deposition with T cell infiltrates precedes fibrosis in murine viral myocarditis. (6/262)

This study was carried out to investigate interstitial fibrin and fibronectin deposition and subsequent myocardial connective tissue abnormalities in BALB/c-nu/+ (euthymic and normal T cell function) and BALB/c-nu/nu (athymic and T cell-deficient) mice. Both types of mice were inoculated with encephalomyocarditis virus and sacrificed periodically. Sections of the hearts were stained with haematoxylin-eosin, trichrome, lymphocyte subsets, silver impregnation, and fibrin or fibronectin. In addition, myocardial collagen concentration was measured. Interstitial fibrin and fibronectin appeared in parallel with inflammatory T lymphocytes and myocardial necrosis in the BALB/c-nu/+ mice. The changes increased until 14 days, subsequently decreasing with time. Interstitial fibrosis and abnormal reticulin fibres were absent until 7 days postinfection, and then increased with time until 60 days. In BALB/c-nu/nu mice, in contrast, although myocardial necrosis and fibrin-fibronectin deposition associated with immature T lymphocytes were evident on days 7 and 14, subsequent myocardial fibrosis and reticulin fibre abnormalities were minimal on days 30 and 60. In BALB/c-nu/+ mice, myocardial collagen concentration increased on day 30, but it did not in BALB/c-nu/nu mice. Thus, interstitial fibrin-fibronectin deposition resulting from virus-induced and T lymphocyte-mediated myocyte necrosis precedes the subsequent development of interstitial fibrosis and abnormal reticulin architectures in this model of murine myocarditis.  (+info)

Theiler's murine encephalomyelitis virus infection induces early expression of c-fos in astrocytes. (7/262)

We have determined whether Theiler's murine encephalomyelitis virus (TMEV), a picornavirus that produces demyelination in genetically susceptible strains of mice, induces c-fos in pure quiescent cultures of mouse brain astrocytes. As observed in Northern blots, the expression of this immediate early gene increases in a dose-dependent manner, with its expression peaking at a multiplicity of infection of 100. The expression of c-fos is transient, peaking after 30 min and disappearing 2 h after infection. The virus is quickly internalized at 37 degrees C upon binding to its specific receptor located at the cell surface and is actively replicated in the cytoplasm of the astrocytes, as demonstrated by FACS flow cytometry. Using the same technique, nuclear translation of c-fos mRNA is also shown. The specificity of viral induction is demonstrated by its neutralization with TMEV-specific antibodies and by the fact that only viral particles and not purified protein components VP1, VP2, and VP3 induced proto-oncogene expression. This rapid induction of c-fos in astrocytes could be the first stage in the infection of these central nervous system cell populations by TMEV. The biological relevance of these findings is assessed by the demonstration of c-fos activation after viral infection in vivo.  (+info)

Potential role of CD4+ T cell-mediated apoptosis of activated astrocytes in Theiler's virus-induced demyelination. (8/262)

Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV) into susceptible mouse strains results in a chronic, immune-mediated demyelinating disease similar to human multiple sclerosis. Here, we examined the role of astrocytes as an APC population in TMEV-induced demyelination and assessed the potential consequences of T cell activation following Ag presentation. IFN-gamma-pretreated astrocytes were able to process and present all the predominant T cell epitopes of TMEV to virus-specific T cell hybridomas, clones, as well as bulk T cells. Despite low levels of proliferation of T cells due to prostaglandins produced by astrocytes, such Ag presentation by activated astrocytes induced the production of IFN-gamma, a representative proinflammatory cytokine, in TMEV-specific Th cell clones derived from the CNS of virus-infected mice. Furthermore, these Th cell clones mediate lysis of the astrocytes in vitro in a Fas-dependent mechanism. TUNEL staining of CNS tissue demonstrates the presence of apoptotic GFAP+ cells in the white matter of TMEV-infected mice. These results strongly suggest that astrocytes could play an important role in the pathogenesis of TMEV-induced demyelination by activating T cells, subsequently leading to T cell-mediated apoptosis of astrocytes and thereby compromising the blood-brain barrier.  (+info)

*Saffold virus

"Saffold Virus, a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): ... Discovered in 2007, it is the first human virus in the Cardiovirus genus and may provide a link to the development of multiple ... This is the first human virus in the Cardiovirus family. Found to occur in high prevalence (>90%) among humans, by analogy SAFV ... Nine strains of SAFV have been identified; these are named SAFV-1 through to SAFV-9. Cardiovirus Picornaviridae Kirkegaard, ...

*Theiler's encephalomyelitis virus

"Saffold Virus, a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): ... Infection initiates in astrocytes and microglia, but persists in macrophages. This strain has been used as an acceptable model ... This is the proposed course of disease in TMEV infection in mice. Many bacteria and viruses infect humans, without pathology in ... The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. As SJL/J mice are ...

*List of MeSH codes (C02)

... cardiovirus infections MeSH C02.782.687.207 --- common cold MeSH C02.782.687.359 --- enterovirus infections MeSH C02.782. ... deltaretrovirus infections MeSH C02.782.815.200.260 --- enzootic bovine leukosis MeSH C02.782.815.200.470 --- htlv-i infections ... rubulavirus infections MeSH C02.782.580.600.680.500 --- mumps MeSH C02.782.580.830 --- rhabdoviridae infections MeSH C02.782. ... avulavirus infections MeSH C02.782.580.600.080.600 --- newcastle disease MeSH C02.782.580.600.400 --- henipavirus infections ...

*Cardiovirus A

... is a member of the Picornaviridae family. Infection with the virus causes encephalomyocarditis and reproductive ...

*Picornain 3C

3C and 3D act similarly in rhinovirus as they do in poliovirus because they are both involved in early viral infection of the ... Picornain 3C is encoded by enteroviruses, rhinoviruses, aphtoviruses and cardioviruses. These genera all cause a wide range of ... Coxsackievirus is shed through stool and bodily fluids and is prevalent in children but can infection occur in adults. Symptoms ... A small amount of poliovirus infections cause paralysis when the virus infects the nervous system. Poliovirus infects host ...

*Picornavirus

Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Genus: Cosavirus Cosavirus A Genus: Dicipivirus Cadicivirus A Genus: ... The whole of replication occurs within the host cell cytoplasm and infection can even happen in cells that do not contain a ... This was the first time that infection virus had been produced from molecular building blocks in the cells. Polyprotein ... However, as little as 30 minutes after initial infection, cell protein synthesis declines to almost zero output - essentially ...

*Mengovirus

There is no specific treatment for a Mengovirus infection; although Persantine has been shown to inhibit its replication. The ... belongs to the genus Cardiovirus which is a member of the Picornaviridae. Its genome is a single stranded positive-sense RNA ...

*Erbovirus

The low serum antibody response of ERBV appears to allow the continual, seasonal re-infection of horses. Horses are also known ... relationship to each other and to aphthoviruses and cardioviruses". J Gen Virol. 77 ( Pt 8) (8): 1719-30. doi:10.1099/0022-1317 ...

*Taxonomic list of viruses

Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Genus: Cosavirus Cosavirus A Genus: Dicipivirus Cadicivirus A Genus: ... Viruses portal Virus Virology Virus classification List of latent human viral infections Table of clinically important viruses ...

*List of virus species

Cardamom mosaic virus Cardiochiles nigriceps bracovirus Cardioderma cor polyomavirus 1 Cardiovirus A Cardiovirus B Cardiovirus ... Taxonomic list of viruses List of genera of viruses Virus Virology Virus classification List of latent human viral infections ...
Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.
Cardiovirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Human and vertebrates serve as natural hosts. There are currently three species in this genus including the type species Cardiovirus A. Diseases associated with this genus include: myocarditis. Cardiovirus A has only one serotype, while Cardiovirus B consists of four viruses which are probably serologically distinct; these are Theilers Murine encephalomyelitis virus (TMEV), Vilyuisk human encephalomyelitis virus (VHEV), a Theiler-like rat virus (TRV) (which has yet to be named) and Saffold virus (SAF-V). Group: ssRNA(+) Order: Picornavirales Family: Picornaviridae Genus: Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Viruses in Cardiovirus are non-enveloped, with icosahedral, Spherical, and Round geometries, and T=pseudo3 symmetry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 7.8kb in length. Viral replication is cytoplasmic. Entry into the host cell is achieved by ...
The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal fluid (CSF) samples from children ...
Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied the role of galectin-3 (Gal-3), a proinflammatory protein. Gal-3 expression was increased in periventricular regions of human MS in post-mortem brain samples and was also upregulated in periventricular regions in a murine MS model, Theilers murine encephalomyelitis virus (TMEV) infection. Whereas TMEV increased SVZ chemokine (CCL2, CCL5, CCL, and CXCL10) expression in wild type (WT) mice, this was inhibited in Gal-3(-/-) mice. Though numerous CD45+ immune cells entered the SVZ of WT mice after TMEV infection, their numbers were significantly diminished in Gal-3(-/-) mice. TMEV also reduced neuroblast and proliferative SVZ cell numbers in WT mice but this was restored in Gal-3(-/-) mice and was correlated with increased
All opinions are my own and do not represent medical advice or the views of any institution.. All graphics made by me are free-to-use. Please just cite the particular page, blog and me. A heads-up would be nice, but that can happen later.. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Definition of Encephalomyocarditis virus with photos and pictures, translations, sample usage, and additional links for more information.
Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S. Reduced Tyk2 gene expression in ß-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun. 2015 Apr 07; 6:6748 ...
Definition of Encephalomyocarditis with photos and pictures, translations, sample usage, and additional links for more information.
The Cardiovirus genus is divided into two species: the Encephalomyocarditis species, which includes encephalomyocarditis virus (EMCV) and mengovirus, and the Theilovirus species, which includes Theilers murine encephalomyelitis virus (TMEV), Vilyuisk human encephalomyelitis virus (VHEV), and Saffold virus (SAFV). This chapter discusses members of the Cardiovirus genus and distinctive characteristics of these viruses. It focuses on the pathogenesis of TMEV-induced disease because of the extensive investigations of this topic as well as the remarkable ability of this virus to establish lifelong infection of the central nervous system (CNS) and to produce an immune-mediated demyelinating disease. There are many features of cardioviruses, and especially TMEV, that make them attractive for pathogenesis studies, including the following: the unusual and rather unique characteristics of TMEV strains and TMEV-induced diseases (neurovirulent versus persistent strains, acute versus chronic disease, virus-induced
Looking for online definition of Cardiovirus in the Medical Dictionary? Cardiovirus explanation free. What is Cardiovirus? Meaning of Cardiovirus medical term. What does Cardiovirus mean?
A single administration of complete Freunds adjuvant (CFA), type 1 carrageenan (Car), or silica 7, 2, and 2 days, respectively, before infection with a low dose (1 × 102 plaque-forming units/mouse) of encephalomyocarditis D (EMC-D) virus resulted in a significant increase in the incidence of diabetes in SJL/J mice (100%) compared with untreated EMC-D virus-infected mice (40%). Peritoneal macrophages were isolated from uninfected SJL/J mice, which had been treated once with silica, and transferred into SJL/J mice 2 days before low-dose EMC-D infection. Approximately 90% of the mice became diabetic, whereas 30% of mice that received virus alone became diabetic. The depletion of macrophages by treatment with the combined anti-Mac-1 and anti-Mac-2 monoclonal antibodies after a single administration of CFA, Car, or silica resulted in almost complete prevention of β-cell destruction in EMC-D virus-infected mice. Furthermore, none of the mice in which macrophages were depleted by long-term treatment ...
In article ,30ncsi$68g at homer.cs.mcgill.ca,, nedellec at binkley.cs.mcgill.ca (Patrick NEDELLEC) wrote: , Hi, , ,I am looking for any information on the Theiler virus (murine ,encephalomyelitis virus) a picornavirus. Hello Patrick: Here at U of Utah , Dr. Robert Fujinami (he has a co-appointment in the Departments of Neurology and Pathology) works on various aspects of Theilers. I rotated with his lab during my first year of Grad School. A few comments from membory, Theilers starts out as an asymptomatic enteric infection that can go on and cause a central nervous system disease. A whole bunch of variants have since then been isolated that are more/less neurovirulent in various strains of mice. I dont know if there is a vaccine available, since (memory time here) unless you are a mouse it probably wont hurt you. As for antibodies, there is at least one neutralizing monoclonal that against viral coat protein 1 (VP-1). I saved some of my background literature he suggested I read, these may ...
Brain atrophy is a common feature of numerous neurological diseases in which the role of neuroinflammation remains poorly defined. We have previously demonstrated the development of brain and spinal cord atrophy in the Theilers murine encephalomyelitis virus (TMEV) model of multiple sclerosis. However, cellular and molecular mechanisms of brain atrophy remain poorly understood. We therefore evaluated the contribution of major histocompatibility (MHC) class I molecules in atrophy development during TMEV infection. To accomplish this, we created a novel transgenic FVB/NJ mouse by introducing the H-2Db (Db) class I molecule. Expression of Db class I molecule confers resistance to persistent TMEV infection and demyelination in the normally susceptible FVB/NJ strain (H2-Dq class I haplotype). Next, we compared the development of brain atrophy, assessed by volumetric analysis of T2-weighted MRIs, in FVB/Db mice to wild-type FVB/NJ mice following viral infection. FVB/NJ mice did not significant brain ...
Virion. Morphology. The crystal structures of mengovirus (Cardiovirus A) and TMEV and Saffold virus 3 (Cardiovirus B) have been resolved [{Grant et al., 1992:1549565RJOHTXGrant et al., 1992, Three-dimensional structure of Theiler virus, Proceedings of the National Academy of Sciences, USA 89, 6, 2061-5RJOMREFKrishnaswamy and Rossmann 1990:2156078RJOHTXKrishnaswamy and Rossmann 1990, Structural refinement and analysis of Mengo virus, J Mol Biol, 211, 4, 803-44}]. Empty capsids are seen only rarely, if ever. When compared by mean wall thickness, surface unevenness, and chain length of the major proteins, the cardiovirus capsid is intermediate between the enteroviruses and aphthoviruses. In place of a continuous, circular canyon seen in enteroviruses, is a five-fold repeated pit. There is no pocket factor.. Physicochemical and physical properties. Virion buoyant density in CsCl is 1.33-1.34 g cm-3. Virions are moderately stable to acidic pH.. Nucleic acid. Length of genome [{Bae et al., ...
Strains of Theilers murine encephalomyelitis virus (TMEV) were first isolated by Max Theiler at the Rockefeller Foundation during his investigations of yellow fever virus vaccine. The GDVII strain of TMEV was named because this isolate was the seventh made by George, Theilers technician, from an uninoculated mouse that was found to be diseased (paralyzed). The presence of polypyrimidine tract binding protein (PTB) and nPTB binding sites in GDVII affects neurovirulence. The importance of sialic acid binding to virus entry is further supported by studies that showed that a variant of DA that has enhanced binding to L929 cells and has mutations in the VP2 puff B or VP1 loop 2; this region is also one that has been found important in disease pathogenesis. It was found that demyelination can occur when one replaces any part of the DA genome with the corresponding segment from the GDVII genome. In addition, the immune system is believed to mediate the pathology in both diseases. Therefore, it is hoped that
Abstract: Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of molecules and effectors, and it requires the transmigration of blood leukocytes across the blood-brain barrier (BBB) and the activation of resident immune cells. Cannabidiol (CBD), a non-psychotropic cannabinoid constituent of Cannabis sativa, has potent anti-inflammatory and immunosuppressive properties. Yet, how this compound modifies the deleterious effects of inflammation in TMEV-induced demyelinating disease (TMEV-IDD) remains unknown. Using this viral model of multiple sclerosis (MS), we demonstrate that CBD decreases the transmigration of blood leukocytes by downregulating the expression of vascular cell adhesion molecule-1 (VCAM-1), chemokines (CCL2 and CCL5) and the proinflammatory cytokine IL-1β, as well as by attenuating the activation of microglia. Moreover, CBD administration at the time of viral infection exerts long-lasting effects, ameliorating motor deficits in the ...
BALB/cJ is a commonly used inbred. Key traits include a susceptibility to developing the demyelinating disease upon infection with Theilers murine encephalomyelitis virus. The BALB/cJ substrain is susceptible to |i|Listeria|/i|, all species of |i|Leishmania|/i|, and several species of |i|Trypanosoma|/i|, but is resistant to experimental allergic orchitis (EAO).
Onodera, T; Jenson, A B.; Yoon, J; and Notkins, A L., "Virus-induced diabetes mellitus: reovirus type 1 infection of pancreatic alpha, beta, and d cells in mice. Abstr." (1979). Subject Strain Bibliography 1979. 1650 ...
Cloning and expression of the gene encoding for the major capsid protein, VP-1, of the D-variant of encephalomyocarditis virus in Escherichia ...
Diagnosis of Viral myocarditis (costs for program #213137) ✔ DKD HELIOS Clinic Wiesbaden ✔ Department of Pediatrics ✔ BookingHealth.com
海词词典,最权威的学习词典,专业出版acute viral myocarditis是什么意思,acute viral myocarditis的用法,acute viral myocarditis翻译和读音等详细讲解。海词词典:学习变容易,记忆很深刻。
Yellow fever was a widespread and deadly disease at that time. The disease is caused by a virus. The virus is spread by the bites of certain types of mosquitoes. Theiler and other researchers wanted to find a vaccine for yellow fever. A vaccine is a substance that protects people from a disease. At first, researchers used rhesus monkeys for yellow fever experiments. In 1930 Theiler discovered that the yellow fever virus also affected mice.…
How long should viral myocarditis last - I have viral myocarditis for three weeks. At my last check-up I had sinus tachycardia and ejection fraction of 26%. Im on three different meds but Im not getting better. What is the probability for full recovery? How long does it usually take? Silly patient. The best answer for your question is provided by the treating physicians, who have the benefit of your history, exam and an understanding of the tests you have had to date. While it is understandable you want answers. We have no crystal ball with great incite based on your present ejection fraction. This is a serious illness, pay attention to your docs advise and you might do well.
Diagnosis of Viral myocarditis (costs for program #211813) ✔ University Hospital RWTH Aachen ✔ Department of Gastroenterology, Metabolic Disorders and Internal Intensive Medicine ✔ BookingHealth.com
Question - Done with brain MRI. Diagnosis of demyelinating disease. Suggestion?. Ask a Doctor about when and why MRI is advised, Ask a Neurologist
The basis for the resistance of the female and the susceptibility of the male ICR Swiss mouse to the diabetogenicity of the D variant of encephalomyocarditis virus (EMCV-D) is unknown. This pattern of disease resistance and susceptibility can be reversed if females are treated with testosterone and males are treated with estrogen before virus infection. As a possible explanation for this sex difference in disease development, differences in early antiviral host responses were explored. Cellular antiviral resistance mechanisms operative early in virus infection were evaluated in ICR Swiss mice of both sexes after intraperitoneal infection with virus. No differences were seen in splenic natural killer (NK) cell responses of male and female mice during the 1st wk of infection, during which only the males became diabetic. Depletion of NK cell activity with rabbit anti-asialo GM1 serum did not render the infected ICR Swiss female susceptible to virus-induced diabetes. Treatment of ICR Swiss mice with type I
One of the main roles of myelin in the central nervous system seems to be related to maintaining a low ionic conductivity around axons (1) and a modification of its composition, intermodular...
TY - JOUR. T1 - Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene. AU - Lin, Amy H.. AU - Liu, Yanzheng. AU - Burrascano, Cynthia. AU - Cunanan, Kathrina. AU - Logg, Christopher R.. AU - Robbins, Joan M.. AU - Kasahara, Noriyuki. AU - Gruber, Harry. AU - Ibañez, Carlos. AU - Jolly, Douglas J.. PY - 2016/4/1. Y1 - 2016/4/1. N2 - We have developed retroviral replicating vectors (RRV) derived from Moloney murine gammaretrovirus with an amphotropic envelope and an encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES)-transgene cassette downstream of the env gene. During long-term (180 days) replication of the vector in animals, a bulge of 7 adenosine residues (As) in the J-K bifurcation domain sometimes serially added As. Therefore, vectors with 4-12 As in the A bulge in the J-K bifurcation domain were generated, and the impact ...
The present study shows an inhibitory role of IRAK4 in viral myocarditis. For the first time, we reveal IRAK4 as a double-edged sword in viral myocarditis: It acts as a proinflammatory molecule but also blocks protective cell migration and antiviral responses. The ability of the host to limit viral proliferation while minimizing tissue injury attributable to detrimental proinflammatory responses, thus protecting from autoimmune postviral cardiomyopathy, is a prerequisite of favorable outcome.. IRAK4 is a well-known proinflammatory kinase downstream of all known TLRs except TLR3. It complexes with MyD88, IRAK1, IRAK2, and IRAK-M, phosphorylates IRAK1 and IRAK2, and ultimately contributes to NF-κB and mitogen-activated protein kinase activation for inflammatory cytokine transcription.5,6,16,17 Accordingly, and as reported by our group earlier, IRAK4-deficient mice showed better survival and lower heart inflammation after experimental myocardial infarction.18 In addition, we recently found that ...
Sorensen, O; Dugre, R; Percy, D; and Dales, S, "In vivo and in vitro models of demyelinating disease: endogen- ous factors influencing demyelinating disease caused by mouse hepatitis virus in rats and mice." (1982). Subject Strain Bibliography 1982. 4405 ...
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Experimental allergic encephalomyelitis (EAE) is the commonest, readily induced, organspecific, autoimmune disorder of laboratory animals of its kind. It is an artificial disorder brought about by the immunization of susceptible animals with brain antigens in complete Freunds adjuvant (CFA). Variations can be induced by altering the nature of the antigen and the conditions involving immunization. Whilst it is often described as a demyelinating disease, in strict terms it is not, since the primary pathologic process is not demyelination but rather an encephalomyelitis that is immunologically induced. Rather, the prototype demyelinating disease is multiple sclerosis and its variants. In this paper, the central question we ask is whether the data gleaned from the EAE model contributes to our understanding of the pathological events in MS. Towards answering this, we describe the historical development of EAE and its hyperacute form, and discuss the findings studied extensively in the non-human ...
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by inflammation and neurodegenerative processes. C...
Mainly vasodilators such as ace inhibitors or angiogtension receptor blockers (arbs), low dose beta blockers, occasionally inotropes such as digoxin, and sometimes vasodilators like calcium channel blockers like Nifedipine or amlodipine or nitrates ...
Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in the CNS) and glial scars or scleroses. They present different shapes and histological findings according to the underlying condition that produces them. Demyelinating diseases are traditionally classified in two kinds: demyelinating myelinoclastic diseases and demyelinating leukodystrophic diseases. In the first group a normal and healthy myelin is destroyed by a toxic, chemical or autoimmune substance. In the second group, myelin is abnormal and degenerates. The second group was denominated dysmyelinating diseases by Poser Therefore, since Poser demyelinating diseases normally refers to the myelinoclastic part. Demyelinating diseases of the CNS can be classified according to their pathogenesis into five non-exclusing categories: demyelination due to inflammatory processes, viral demyelination, demyelination caused by acquired metabolic derangements, hypoxic-ischaemic ...
The industry news information and articles are for informational purposes only, and are not intended to represent any trends, partnerships, commitments, or research of the Consortium of MS Centers or any of its members in any way whatsoever, nor should any party be libel in any way to the reader or to any other person, firm or corporation reading this industry news section. Although the CMSC site includes links providing direct access to other Internet sites, CMSC takes no responsibility for the content or information contained on those other sites, and does not exert any editorial or other control over those other sites. CMSC is providing information and services on the Internet as a benefit and service in furtherance of CMSCs nonprofit and tax-exempt status. CMSC makes no representations about the suitability of this information and these services for any purpose.. ...
The industry news information and articles are for informational purposes only, and are not intended to represent any trends, partnerships, commitments, or research of the Consortium of MS Centers or any of its members in any way whatsoever, nor should any party be libel in any way to the reader or to any other person, firm or corporation reading this industry news section. Although the CMSC site includes links providing direct access to other Internet sites, CMSC takes no responsibility for the content or information contained on those other sites, and does not exert any editorial or other control over those other sites. CMSC is providing information and services on the Internet as a benefit and service in furtherance of CMSCs nonprofit and tax-exempt status. CMSC makes no representations about the suitability of this information and these services for any purpose.. ...
Free, official coding info for 2018 ICD-10-CM G37.9 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
ITAHARA K. Annual report of the Ministry of Health and Welfare demyelinating disease research committee, workshop for 1977, Japan, 1977 被引用文献1件 ...
Unite dImmunite Cellulaire Antivirale, Institut Pasteur, 75724 Paris Cedex 15, France. The persistent and demyelinating infection by Theilers virus is a model for multiple sclerosis. A major locus of susceptibility to the persistence of Theilers virus (Tmevp1) has been mapped to the H-2D region. The b haplotype confers resistance, the q haplotype confers a high level of susceptibility and d, k and s haplotypes are associated with an intermediate level of susceptibility. The resistant b haplotype is dominant over all the others. The SJL/J strain is an exception, being more susceptible to persistent infection than predicted by its H-2s haplotype. This has been ascribed to the existence of non H-2 susceptibility genes. Strains of intermediate susceptibility, such as the B10.S strain (H-2s), are infected at low level but their F1 cross with the SJL/J strain are highly susceptible. Results from different groups demonstrated that the H-2D gene controls viral persistence and/or demyelination. We now ...
The only previous MAC player taken fifth overall was Buffalo Khalil Mack, who went to Oakland in 2014 and is now the reigning NFL defensive player of the year.. Obviously, we play a lot of really good pass rushers and our objective is to keep No. Saffold describes his relationship with the Rams new veteran linemen as telepathic.. The marketer said in October that it was testing early versions of four different potential approaches, some with celebrities and some without, some related to football more than others, all emphasizing the year round availability of the product. What Is the Starting Salary for an ESPN Sports Commentator? by Jonathan Lister ; Updated September 26, 2017 The starting salary of an ESPN commentator depends largely on name, personality and experience in the field. The Dolphins had a chance to tie the game at 17 in the third quarter. Would be too confusing to many of the voters and that would not be fair to do to them. There are some around Allen Park who were impressed with ...
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A well-known international journal, BMC Neurology advances the understanding, prevention, and treatment of neurological diseases. Acceptance of various ...
As a minor comment -- I dont think that we could say that the Zika virus proteins arent there. Brain matter is going to be super complex and separation on a 15cm column for 180minutes is not going to provide ultra-deep proteome coverage, but this is pretty interesting. If we think of lethal viral models that hijack host cells and then produce tons and tons of themselves -- youd expect the Zika proteins to be at high abundance. Or at least I would. It is at least super weird that another virus appears to be running amuck -- in the brain -- in 3 different individuals ...
Heike A. Bischoff-Ferrari, MD, DrPH; Bess Dawson-Hughes, MD; Andreas Platz, MD; Endel J. Orav, PhD; Hannes B. Stähelin, MD; Walter C. Willet, MD, DrPH; Uenal Can, MD; Andreas Egli, MD; Nicolas J. Mueller, MD; Silvan Looser, PT; Beat Bretscher, PT; Elisabeth Minder, MD; Athanasios Vergopoulos, MD; Robert Theiler MD; Mai ...
Explore the latest in neurology, including recent guidelines and advances in management of stroke, dementia, demyelinating disease, and more.
Archives of the Balkan Medical Union este inclusă începând cu 2017 în Nomenclatorul publicațiilor medicale recunoscute de Colegiul Medicilor din România. Astfel, abonații revistei beneficiază de 10 credite EMC/an iar autorii articolelor publicate în revistă beneficiază de 80 de credite suplimentare EMC/articol, toate articolele publicate luându-se în considerare pentru calculul punctajului profesional al autorilor, în eventualitatea sustinerii unor concursuri ...
Archives of the Balkan Medical Union este inclusă începând cu 2017 în Nomenclatorul publicațiilor medicale recunoscute de Colegiul Medicilor din România. Astfel, abonații revistei beneficiază de 10 credite EMC/an iar autorii articolelor publicate în revistă beneficiază de 80 de credite suplimentare EMC/articol, toate articolele publicate luându-se în considerare pentru calculul punctajului profesional al autorilor, în eventualitatea sustinerii unor concursuri ...

Immunodepletion of inflammatory monocytes preserves cog | Open-iImmunodepletion of inflammatory monocytes preserves cog | Open-i

Cardiovirus Infections/immunology/pathology*. *Hippocampus/immunology/pathology*/virology. *Monocytes/immunology/pathology*/ ... Bottom Line: Identification of the immune effectors responsible for injuring the brain during acute infection is necessary for ... Bottom Line: Identification of the immune effectors responsible for injuring the brain during acute infection is necessary for ... Background: Neuropathology caused by acute viral infection of the brain is associated with the development of persistent ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3368782_1742-2094-9-50-10&req=4

Japanese Journal of Infectious Diseases Page 9Japanese Journal of Infectious Diseases Page 9

Saffold cardiovirus infection in a 2-year-old boy with acute pancreatitis.. This report presents a unique case which developed ... Abstract The urinary tract infection (UTI) is one of the most common infections in human, primarily caused by uropathogenic ... Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report.. PMID ... High Rates of Hepatitis B, Hepatitis C and Human Immunodeficiency Virus (HBV, HCV, HIV) Infections and Their Uncommon HBV ...
more infohttps://medworm.com/journal/japanese-journal-of-infectious-diseases/9/

Mosaic VirusMosaic Virus

Prevention and Control of Cardiovirus Infections Thu, 20 Jul 2017 , Mosaic Virus ... Viruses may cause acute infection (hepatitis A virus) or acute infection with the possibility for chronic liver infection ... Clinical Features of Enteric Infection. *Clinical Features of Infection - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 ... Industries Affected by Phage Infection Thu, 27 Apr 2017 , Mosaic Virus Reliable data on the severity of phage infection of ...
more infohttps://www.centrallakesclinic.biz/mosaic-virus/

Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China - Volume 16, Number 7-July...Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China - Volume 16, Number 7-July...

We detected SAFV in 7 (0.5%) patients and identified lineages 1-3. However, because 3 patients had co-infections, we could not ... To clarify the potential for respiratory transmission of Saffold cardiovirus (SAFV) and characterize the pathogen, we analyzed ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China On This Page ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China. Emerging Infectious Diseases ...
more infohttps://wwwnc-origin.cdc.gov/eid/article/16/7/09-1682

Figure 2 - Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China - Volume 16,...Figure 2 - Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China - Volume 16,...

We detected SAFV in 7 (0.5%) patients and identified lineages 1-3. However, because 3 patients had co-infections, we could not ... To clarify the potential for respiratory transmission of Saffold cardiovirus (SAFV) and characterize the pathogen, we analyzed ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China Lili Ren, Richard Gonzalez, ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China. ...
more infohttps://wwwnc-origin.cdc.gov/eid/article/16/7/09-1682-f2

SelfDecode | Genome AnalysisSelfDecode | Genome Analysis

Cardiovirus Infections TNF. Cecal Neoplasms TRP53. Central Nervous System Diseases EPO. Central Nervous System Neoplasms TP53. ...
more infohttps://www.selfdecode.com/molecular-function/GO:0009651/

SelfDecode | Genome AnalysisSelfDecode | Genome Analysis

Cardiovirus Infections TNF. Intracerebral Hemorrhage CASP8. Chlamydia Infections TNF. Cholestasis TNF. Colitis TNF. ...
more infohttps://www.selfdecode.com/molecular-function/GO:0071550/

Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru - Volume 15, Number 4-April 2009 - Emerging...Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru - Volume 15, Number 4-April 2009 - Emerging...

The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse ... Serum samples from case-patient 1 showed cardiovirus antibody by immunoglobulin M ELISA (acute phase <8, convalescent phase ... Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness. ... symptoms impossible to associate unequivocally with the cardiovirus infection. In other human picornavirus infections, virus ...
more infohttps://wwwnc.cdc.gov/eid/article/15/4/08-1428_article

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Cardiovirus Infections - pathology , Cardiovirus Infections - immunology , Interleukin-6 - secretion , Cardiovirus Infections ... Cardiovirus - pathogenicity , Humans , Cardiovirus Infections - metabolism , Cercopithecus aethiops , Cardiovirus Infections - ... Cardiovirus Infections - metabolism , Multiple Sclerosis - immunology , Cardiovirus Infections - physiopathology , Cardiovirus ... INFECTIONS , CARDIOVIRUSES , MULTIDISCIPLINARY SCIENCES , GROWTH , CHILDREN , Cardiovirus - growth & development , Cardiovirus ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Cardiovirus%20-%20pathogenicity

The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in...The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in...

RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochem Biophys Res Commun 480: 187-193 ... Backes S, Langlois RA, Schmid S, Varble A, Shim JV, Sachs D, tenOever BR (2014) The mammalian response to virus infection is ... Matskevich AA, Moelling K (2007) Dicer is involved in protection against influenza A virus infection. J Gen Virol 88: 2627-2635 ... HEK293 cells were transfected with FLAG‐LGP2 for 24 h followed by infection with EMCV at the indicated MOI for 6 h. Cells were ...
more infohttp://emboj.embopress.org/content/37/4/e97479

Julie Parsonnet | Stanford Medicine ProfilesJulie Parsonnet | Stanford Medicine Profiles

Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections PROCEEDINGS OF THE ... pylori infection, when compared with CagA(-) infection or the absence of H. pylori infection, is associated with a higher ... Maternal infection with Helicobacter pylori as a risk factor for infection in children of different ages Tamburini, B. A., Tsai ... THE INCIDENCE OF HELICOBACTER-PYLORI INFECTION Roundtable Meeting on Epidemiology of Helicobacter pylori Infection Parsonnet, J ...
more infohttps://med.stanford.edu/profiles/julie-parsonnet

Genus: Cardiovirus - Picornaviridae - Picornavirales - International Committee on Taxonomy of Viruses (ICTV)Genus: Cardiovirus - Picornaviridae - Picornavirales - International Committee on Taxonomy of Viruses (ICTV)

Boone cardioviruses were detected in specimens of rats. Cardiovirus infection does not cause cleavage of the host eIF-4G. The ... The crystal structures of mengovirus (Cardiovirus A) and TMEV and Saffold virus 3 (Cardiovirus B) have been resolved [{Grant et ... The orthologous 2A protein of Boone cardioviruses (Cardiovirus C) is shorter (127 aa) and lacks an NPG↓P motif. ... Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections, Proceedings of the ...
more infohttps://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae/678/genus-cardiovirus/revision/2

Helicase Regulation of dsRNA Signaling and Innate Antiviral Immune Responses - Curt HorvathHelicase Regulation of dsRNA Signaling and Innate Antiviral Immune Responses - Curt Horvath

2016) The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochem Biophys Res ... A major contribution to host immune responses to virus infection is the production of and response to type I interferon (IFN). ... Virus infection or accumulated virus replication intermediates like double-stranded RNA (dsRNA) can trigger IFN biosynthesis in ...
more infohttp://grantome.com/grant/NIH/R01-AI073919-04

Hide: its easy when no-ones looking - Virology Down UnderHide: it's easy when no-one's looking - Virology Down Under

Saffold Cardiovirus Infection in Children Associated With Respiratory Disease and Its Similarity to Coxsackievirus Infection. ... www.picornaviridae.com/cardiovirus/cardiovirus_b/safv_seqs.htm. *Sequence and phylogenetic analyses of Saffold cardiovirus from ... Many children and adults worldwide have antibodies to a SAFV, indicating past infection.[3-7] These infections seem to happen ... Saffold cardiovirus (SAFV) was first described in 2007,[from a 1981 human sample; 10] and since then has been found to consist ...
more infohttp://virologydownunder.com/hide-its-easy-when-no-ones-looking/?shared=email&msg=fail

NAVER Academic > Search...NAVER Academic > Search...

Animals, Capsid Proteins, chemistry, genetics, Cardiovirus Infections, virology, Cells, Cultured, Encephalomyocarditis virus, ... Infection of macaques with an R5-tropic SHIV bearing a chimeric envelope carrying subtype E V3 loop among subtype B framework. ... Adolescent, Adult, DNA Virus Infections, epidemiology, Female, Genetic Variation, Humans, Kidney Transplantation, Male, Middle ...
more infohttps://academic.naver.com/search.naver?field=3&query=Archiv+f%C3%BCr+die+gesamte+Virusforschung+148%EA%B6%8C+5%ED%98%B8

Ikuo Tsunoda Louisiana State University Laboratory 角田郁生ルイジアナ州立大学研究室Ikuo Tsunoda Louisiana State University Laboratory 角田郁生ルイジアナ州立大学研究室

Upregulation of chemokines and interferon-associated genes in a novel model for myocarditis induced by cardiovirus infection. ... 2003). Modulation of immune system function by measles virus infection. II. Infection of B cells leads to the production of a ... 2004). Distinct roles for IP-10/CXCL10 in three animal models, Theilers virus infection, EAE, and MHV infection, for multiple ... "Axonal degeneration in neurotropic virus infection." Sendai, Miyagi, Japan, January 27, 2009.PDF. 東北大学医学部免疫学講座 菅村 和夫教授に
more infohttp://www.med.kindai.ac.jp/microbio/nihongopublication.html

Cardium - definition of Cardium by The Free DictionaryCardium - definition of Cardium by The Free Dictionary

Cardiovirus. *Cardiovirus. *Cardiovirus infections. *Cardiovirus infections. *cardiovocal syndrome. *CARDIS. *carditic. * ...
more infohttps://www.thefreedictionary.com/Cardium

Cardioversion - definition of cardioversion by The Free DictionaryCardioversion - definition of cardioversion by The Free Dictionary

Cardiovirus. *Cardiovirus. *Cardiovirus infections. *Cardiovirus infections. *cardiovocal syndrome. *CARDIS. *carditic. * ...
more infohttps://www.thefreedictionary.com/cardioversion

Saffold virus - WikipediaSaffold virus - Wikipedia

"Saffold Virus, a Human Theilers-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): ... Discovered in 2007, it is the first human virus in the Cardiovirus genus and may provide a link to the development of multiple ... This is the first human virus in the Cardiovirus family. Found to occur in high prevalence (>90%) among humans, by analogy SAFV ... Nine strains of SAFV have been identified; these are named SAFV-1 through to SAFV-9. Cardiovirus Picornaviridae Kirkegaard, ...
more infohttps://en.wikipedia.org/wiki/Saffold_virus

Theilers encephalomyelitis virus - WikipediaTheiler's encephalomyelitis virus - Wikipedia

"Saffold Virus, a Human Theilers-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): ... Infection initiates in astrocytes and microglia, but persists in macrophages. This strain has been used as an acceptable model ... This is the proposed course of disease in TMEV infection in mice. Many bacteria and viruses infect humans, without pathology in ... The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. As SJL/J mice are ...
more infohttps://en.wikipedia.org/wiki/Theiler's_encephalomyelitis_virus

Experts and Doctors on animals in Chicago, Illinois, United StatesExperts and Doctors on animals in Chicago, Illinois, United States

cardiovirus infections*equilenin*maus elberfeld virus*myosin light chain kinase*desmosomes*adherens junctions*hartmannella*g12 ... Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics. 2008;178: ...
more infohttp://www.labome.org/locale/united/illinois/experts-and-doctors-on-animals-in-chicago--illinois--united-states-12007.html

Welcome to CDC stacks | Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans - 17307 | Emerging Infectious...Welcome to CDC stacks | Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans - 17307 | Emerging Infectious...

Cardiovirus Cardiovirus Infections Child Child, Preschool Feces Gastroenteritis Germany Humans Infant Infant, Newborn Middle ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China ... The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause ... Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We ...
more infohttps://stacks.cdc.gov/view/cdc/17307

Welcome to CDC stacksWelcome to CDC stacks

Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been ... Infections caused by enteroviruses (EV) and parechoviruses (PeV), members of the Picornaviridae family, are associated with ... We report a case of myocarditis associated with human parechovirus (HPeV) infection in an adult. HPeV is an emerging pathogen ... Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple ...
more infohttps://stacks.cdc.gov/view/cdc/47948/Print
  • Neuropathology caused by acute viral infection of the brain is associated with the development of persistent neurological deficits. (nih.gov)
  • These effector cells may be important therapeutic targets for immunomodulatory or immunosuppressive therapies aimed at reducing or preventing central nervous system pathology associated with acute viral infection. (nih.gov)
  • EMC viruses have a poly(C) tract of variable length (usually 80-250 nt) about 150 nt from the 5′-terminus of the viral RNA, while the other cardioviruses lack this feature. (ictvonline.org)
  • Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness. (cdc.gov)
  • Infection with EMCV is associated with sporadic cases and outbreaks of myocarditis and encephalitis in domestic pigs, in numerous species of nonhuman primates, and in other mammalian species ( 2 - 8 ). (cdc.gov)
  • Human EMCV infection and disease have been documented by virus isolation from several specimen types, including serum, stool samples, cerebral spinal fluid, and throat washings ( 10 - 12 ). (cdc.gov)
  • When compared by mean wall thickness, surface unevenness, and chain length of the major proteins, the cardiovirus capsid is intermediate between the enteroviruses and aphthoviruses. (ictvonline.org)
  • K. Shen) tients exhibited symptoms of respiratory tract infection, DOI: 10.3201/eid1607.091682 such as coughing, gasping, sneezing, or fever. (cdc.gov)
  • Virus infection or accumulated virus replication intermediates like double-stranded RNA (dsRNA) can trigger IFN biosynthesis in most cells irrespective of the presence of Toll-like receptor systems. (grantome.com)
  • Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain. (nih.gov)
  • Specific depletion of neutrophils with the 1A8 antibody failed to preserve neurons, suggesting that inflammatory monocytes are the key effectors of brain injury during acute picornavirus infection of the brain. (nih.gov)
  • The cardiovirus L protein is a unique picornavirus protein with Zn-finger domain (C-x-H-x 6 -C-x 2 -C) playing key roles in (i) the regulation of virus translation, (ii) phosphorylation of nucleoporins, and (iii) inhibition of interferon synthesis. (ictvonline.org)
  • Neutrophils and inflammatory monocytes rapidly and robustly responded to Theiler's virus infection by infiltrating the brain. (nih.gov)
  • A major contribution to host immune responses to virus infection is the production of and response to type I interferon (IFN). (grantome.com)
  • She has a particular interest in gastrointestinal infections, including H. pylori infection and diarrheal diseases, tuberculosis and illnesses with prolonged fever. (stanford.edu)
  • The disease is often fatal-frequently, sudden death is the first indication of infection-and most outbreaks have been associated with captive animals, such as those found in piggeries, primate research centers, and zoos. (cdc.gov)
  • Identification of the immune effectors responsible for injuring the brain during acute infection is necessary for the development of therapeutic strategies that reduce neuropathology but maintain immune control of the virus. (nih.gov)
  • Abstract Cases of autochthonous dengue virus type 1 (DENV-1) infections were detected in Japan following a 70-year period devoid of dengue outbreaks. (medworm.com)
  • The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. (cdc.gov)
  • Interestingly, as reported in other studies, including our own from 2012, the Japanese study found quite a high proportion of co-infections, in other words, more than one virus identified per sample tested. (virologydownunder.com)
  • Neurotropic virus infection downregulates lymphatic molecules, suppressing lymphocyte exit from the central nervous system. (kindai.ac.jp)
  • This is the first human virus in the Cardiovirus family. (wikipedia.org)
  • Of the 3 children with AiV infection, the 3 AiV strains were found to belong to genotype A based on the phylogenetic analysis of their partial VP1 and 3CD regions. (biomedcentral.com)
  • 3. The effects of antimicrobial chemicals in personal care products on infection, inflammation, endocrine function and the microbiome. (stanford.edu)
  • Dr. Parsonnet also has an active research enterprise in which she studies the way infections contribute to the development of chronic diseases including cancer, allergy and obesity. (stanford.edu)
  • Four sporadic pediatric cases of Yersinia enterocolitica O:8 infection in rural area of Japan. (medworm.com)
  • Antibody prevalence varied somewhat from study to study, but seropositivity rates tended to increase in persons of advancing age, consistent with a continuous risk for infection throughout life. (cdc.gov)
  • Inflammatory monocytes, defined as CD45hiCD11b++F4/80+Gr1+1A8-, and neutrophils, defined as CD45hiCD11b+++F4/80-Gr1+1A8+, were found in the brain at 12 h after infection. (nih.gov)
  • One hypothesis to the initiation is that an infection stimulates the innate immune system, specifically perivascular microglia. (wikipedia.org)
  • The cardiovirus 2A protein contains an NPG↓P motif and additional domains facilitating nucleolar localization, rRNA binding, and inhibition of cap-dependent cellular mRNA translation. (ictvonline.org)
  • Like other temperate phages, P22 can follow either of two pathways following infection of a sensitive host cell it can grow lyrically, or form a lysogen. (centrallakesclinic.biz)