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The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
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Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
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The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
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Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. (1/262)
Theiler's murine encephalomyelitis viruses are picornaviruses that can infect the central nervous system. The DA strain produces an acute polioencephalomyelitis followed by a chronic demyelinating disease in its natural host, the mouse. The ability of DA virus to induce a demyelinating disease renders this virus infection a model for human demyelinating diseases such as multiple sclerosis. Here we describe the generation and characterization of DA virus mutants that contain specific mutations in the viral capsid protein VP1 at sites believed to be important contact regions for the cellular receptor(s). A mutant virus with a threonine-to-aspartate (T81D) substitution in VP1 loop I adjacent to the putative virus receptor binding site exhibited a large-plaque phenotype but had a slower replication cycle in vitro. When this mutant virus was injected into susceptible mice, an altered tropism was seen during the acute stage of the disease and the chronic demyelinating disease was not produced. A virus with a threonine-to-valine substitution (T81V) did not cause any changes in the pattern or extent of disease seen in mice, whereas a virus with a tryptophan substitution at this position (T81W) produced a similar acute disease but was attenuated for the development of the chronic disease. A change in amino acids in a hydrophobic patch located in the wall of the pit, VP1 position 91, to a hydrophilic threonine (V91T) resulted in a profound attenuation of the acute and chronic disease without persistence of virus. This report illustrates the importance of the loop I of VP1 and a site in the wall of the pit in pathogenesis and that amino acid substitutions at these sites result in altered virus-host interactions. (+info)Differentiation of M1 myeloid precursor cells into macrophages results in binding and infection by Theiler's murine encephalomyelitis virus and apoptosis. (2/262)
Infection of susceptible mouse strains with BeAn, a less virulent strain of Theiler's murine encephalomyelitis virus (TMEV), results in immune system-mediated demyelinating lesions in the central nervous system (CNS) similar to those in multiple sclerosis. Since macrophages appear to carry the major detectable antigen burden in vivo, and purification of sufficient cell numbers from the CNS for detailed analysis is difficult, macrophage-like cell lines provide an accessible system with which to study virus-macrophage interactions. The myeloid precursor cell line M1 differentiates in response to cytokines and expresses many characteristics of tissue macrophages. Incubation of TMEV with undifferentiated M1 cells produced neither infection nor apoptosis, whereas differentiated M1 (M1-D) cells developed a restricted virus infection and changes indicative of apoptosis. Virus binding and RNA replication as well as cellular production of alpha/beta interferons increased with differentiation. Although the amount of infectious virus was highly restricted, BeAn-infected M1-D cells synthesized and appropriately processed virus capsid proteins at levels comparable to those for permissive BHK-21 cells. Analysis of Bcl-2 protein family expression in undifferentiated and differentiated cells suggests that susceptibility of M1-D cells to apoptosis may be controlled, in part, by expression of the proapoptotic alpha isoform of Bax and Bak. These data suggest that macrophage differentiation plays a role in susceptibility to TMEV infection and apoptosis. (+info)Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. (3/262)
OBJECTIVES: This study was designed to examine the effects of pimobendan in a murine model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide (NO) synthesis by inducible NO synthase (iNOS) in the heart. BACKGROUND: Pimobendan has been recently confirmed to improve both acute and chronic heart failure. Since the modulation of myocardial necrosis and contractile dysfunction by various proinflammatory cytokines may be partially mediated by the production of nitric oxide, the effects of pimobendan on the production ofproinflammatory cytokines and NO were investigated in an animal model of viral myocarditis involving heart failure. METHODS: DBA/2 mice were inoculated with the encephalomyocarditis virus. To observe its effect on survival up to 14 days, pimobendan (0.1 mg/kg or 1 mg/kg) or vehicles were given from the day of virus inoculation (day 0) orally once daily. The effects of pimobendan on histological changes, cytokine production, NO production and iNOS gene expression in the heart were studied in mice treated either with pimobendan, 1 mg/kg or with vehicles only, and sacrificed seven days after virus inoculation. RESULTS: The survival of mice improved in a dose-dependent fashion such that a significant difference (p < 0.02) was found between the higher-dose pimobendan group (20 of 30 [66.7%]) and the control group (11 of 30 [36.7%]). Histological scores for cellular infiltration (1.1+/-0.1 vs. 2.0+/-0.0, p < 0.001), intracardiac tumor necrosis factor (TNF)-alpha (18.2+/-1.8 vs. 35.8+/-4.2 pg/mg heart, p < 0.001) and interleukin (IL)-1beta (9.3 +/-1.2 vs. 26.6+/-7.1 pg/mg heart, p < 0.01) were significantly lower in the mice given pimobendan versus those of the control mice. Interleukin-6 levels (7.1+/-0.8 vs. 9.2+/-1.9 pg/mg heart) were also lower in the mice treated with pimobendan. Furthermore, intracardiac NO production was significantly (p < 0.001) less in the pimobendan group (0.165+/-0.004 nmol/mg heart) than in the control group (0.291+/-0.051 nmol/mg heart), and intracardiac iNOS gene expression in the mice given pimobendan was 74% lower than it was in the control animals (p < 0.01). CONCLUSIONS: These findings suggest that the beneficial effects of pimobendan in viral myocarditis are partially mediated by the inhibition of both proinflammatory cytokine production and NO synthesis by iNOS. (+info)Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (4/262)
Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on cardiovascular development and disease, transgenic mice were created in which the mouse preproendothelin-1 promoter was used to target elafin overexpression to the cardiovascular system. To distinguish the transgene from endogenous elafin, constructs were made incorporating a FLAG sequence; the COOH-terminus FLAG-tagged elafin construct produced a stable, functionally active gene product and was used to create transgenic mice. Consistent with endothelin expression, abundant elafin mRNA was observed in transgenic F1 embryos (embryonic day 13.5) and in adult transgenic mice heart, trachea, aorta, kidney, lung, and skin, but not in liver, spleen, and intestine. Functional activity of the transgene was confirmed by heightened myocardial elastase inhibitory activity. No tissue abnormalities were detected by light microscopy or elastin content. However, injection of 10 plaque-forming units (PFU) of encephalomyocarditis virus resulted in death within 11 days in 10 out of 12 nontransgenic mice compared with one out of nine transgenic littermates. This reduced mortality was associated with better cardiac function and less myocardial inflammatory damage. Thus, elafin expression may confer a protective advantage in myocarditis and other inflammatory diseases. (+info)Encephalomyocarditis (EMC) virus infection in PC12 and C6 cells. (5/262)
PC12 cells derived rom rat pheochromocytoma and C6 cells derived from rat glioma were infected with 0.3 plaque forming units (PFU)/cell of the D variant of encephalomyocarditis virus (EMC-D), after pretreatment with or without nerve growth factor (NGF). The virus titres in medium and cells were investigated at 6, 12, 24, 48 and 72 h post infection (HPI), and histopathology and viral antigens in cells were examined at 24 and 48 HPI, respectively. As a result, neither viral replication nor light and electron microscopic changes were observed in PC12 cell cultures without NGF-pretreatment. On the contrary, in PC12 cell cultures with NGF-pretreatment, the virus titre prominently increased at 12 HPI, and peaked at 48 HPI. In addition, distinct histological and ultrastructural changes with viral antigens in cells were observed. C6 cells showed similar morphology and susceptibility to EMC-D-infection irrespective of NGF-pretreatment. Namely, the virus titres in C6 cell cultures increased slightly and viral antigens were found in a small number of C6 cells, but there were no evident histological and ultrastructural changes. These results suggest that PC12 cells pretreated with NGF and C6 cells are susceptible to EMC-D infection in vitro. (+info)Interstitial fibrin-fibronectin deposition with T cell infiltrates precedes fibrosis in murine viral myocarditis. (6/262)
This study was carried out to investigate interstitial fibrin and fibronectin deposition and subsequent myocardial connective tissue abnormalities in BALB/c-nu/+ (euthymic and normal T cell function) and BALB/c-nu/nu (athymic and T cell-deficient) mice. Both types of mice were inoculated with encephalomyocarditis virus and sacrificed periodically. Sections of the hearts were stained with haematoxylin-eosin, trichrome, lymphocyte subsets, silver impregnation, and fibrin or fibronectin. In addition, myocardial collagen concentration was measured. Interstitial fibrin and fibronectin appeared in parallel with inflammatory T lymphocytes and myocardial necrosis in the BALB/c-nu/+ mice. The changes increased until 14 days, subsequently decreasing with time. Interstitial fibrosis and abnormal reticulin fibres were absent until 7 days postinfection, and then increased with time until 60 days. In BALB/c-nu/nu mice, in contrast, although myocardial necrosis and fibrin-fibronectin deposition associated with immature T lymphocytes were evident on days 7 and 14, subsequent myocardial fibrosis and reticulin fibre abnormalities were minimal on days 30 and 60. In BALB/c-nu/+ mice, myocardial collagen concentration increased on day 30, but it did not in BALB/c-nu/nu mice. Thus, interstitial fibrin-fibronectin deposition resulting from virus-induced and T lymphocyte-mediated myocyte necrosis precedes the subsequent development of interstitial fibrosis and abnormal reticulin architectures in this model of murine myocarditis. (+info)Theiler's murine encephalomyelitis virus infection induces early expression of c-fos in astrocytes. (7/262)
We have determined whether Theiler's murine encephalomyelitis virus (TMEV), a picornavirus that produces demyelination in genetically susceptible strains of mice, induces c-fos in pure quiescent cultures of mouse brain astrocytes. As observed in Northern blots, the expression of this immediate early gene increases in a dose-dependent manner, with its expression peaking at a multiplicity of infection of 100. The expression of c-fos is transient, peaking after 30 min and disappearing 2 h after infection. The virus is quickly internalized at 37 degrees C upon binding to its specific receptor located at the cell surface and is actively replicated in the cytoplasm of the astrocytes, as demonstrated by FACS flow cytometry. Using the same technique, nuclear translation of c-fos mRNA is also shown. The specificity of viral induction is demonstrated by its neutralization with TMEV-specific antibodies and by the fact that only viral particles and not purified protein components VP1, VP2, and VP3 induced proto-oncogene expression. This rapid induction of c-fos in astrocytes could be the first stage in the infection of these central nervous system cell populations by TMEV. The biological relevance of these findings is assessed by the demonstration of c-fos activation after viral infection in vivo. (+info)Potential role of CD4+ T cell-mediated apoptosis of activated astrocytes in Theiler's virus-induced demyelination. (8/262)
Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV) into susceptible mouse strains results in a chronic, immune-mediated demyelinating disease similar to human multiple sclerosis. Here, we examined the role of astrocytes as an APC population in TMEV-induced demyelination and assessed the potential consequences of T cell activation following Ag presentation. IFN-gamma-pretreated astrocytes were able to process and present all the predominant T cell epitopes of TMEV to virus-specific T cell hybridomas, clones, as well as bulk T cells. Despite low levels of proliferation of T cells due to prostaglandins produced by astrocytes, such Ag presentation by activated astrocytes induced the production of IFN-gamma, a representative proinflammatory cytokine, in TMEV-specific Th cell clones derived from the CNS of virus-infected mice. Furthermore, these Th cell clones mediate lysis of the astrocytes in vitro in a Fas-dependent mechanism. TUNEL staining of CNS tissue demonstrates the presence of apoptotic GFAP+ cells in the white matter of TMEV-infected mice. These results strongly suggest that astrocytes could play an important role in the pathogenesis of TMEV-induced demyelination by activating T cells, subsequently leading to T cell-mediated apoptosis of astrocytes and thereby compromising the blood-brain barrier. (+info)
Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theilers virus-infected mice<...
Epitopes described in Rapid formation of extended processes and engagement of Theilers virus-infected neurons by CNS...
The role of CD8+T cells in the acute and chronic phases of Theilers murine encephalomyelitis virus-induced disease in mice -...
The role of CD8+T cells in the acute and chronic phases of Theilers murine encephalomyelitis virus-induced disease in mice -...
Cardiovirus - Wikipedia
Welcome to CDC stacks | Serious Invasive Saffold Virus Infections in Children, 2009 - 23631 | Emerging Infectious Diseases
Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection | Journal of...
Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model...
New Saffold cardioviruses in 3 children, Canada. - Free Online Library
Site-specific cleavage of the host poly(A) binding protein by the encephalomyocarditis virus 3C proteinase stimulates viral...
saffold virus Archives - Virology Down Under
Theilers virus infection induces a specific cytotoxic T lymphocyte response. - PubMed - NCBI
Encephalomyocarditis virus: Definition with Encephalomyocarditis virus Pictures and Photos
Encephalomyocarditis virus | Profiles RNS
Encephalomyocarditis: Definition with Encephalomyocarditis Pictures and Photos
ASMscience | Theilers Virus Central
Infiltrating macrophages are key to the development of seizures following virus infection<...
Cardiovirus | definition of Cardiovirus by Medical dictionary
Thomas Michiels | Institut de Duve
Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection<...
Picornaviruses
Stem Cell Therapy for Patients With Multiple Sclerosis Failing Alternate Approved Therapy- A Randomized Study - Full Text View ...
IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis -...
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Persistence of theilers virus infection following promotion of central nervous system remyelination<...
Transgenic expression of H-2Db class I molecules influences the development of brain atrophy during Picornavirus infection |...
Genus: Cardiovirus - Picornaviridae - Picornavirales - International Committee on Taxonomy of Viruses (ICTV)
ASMscience | Pathogenesis of Theiler&
Medical Marijuana News Channel.com: Study: Cannabidiol provides long-lasting protection against the deleterious effects of...
000651 - BALB/cJ
Macrophages and resistance to JHM virus CNS infection.<...
Virus-induced diabetes mellitus: reovirus type 1 infection of pancreat by T Onodera, A B. Jenson et al.
Antiviral Resistance of Splenocytes in Aged Mice<...
A factor that specifically binds to the 5-untranslated region of encephalomyocarditis virus RNA
Cloning and expression of the gene encoding for the major capsid protein, VP-1, of the D-variant of encephalomyocarditis virus...
Arterial Structure and Function Following Viral Myocarditis
Diagnosis of Viral myocarditis: Costs for treatment #213137 in Germany | BookingHealth
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How long should viral myocarditis last - Things You Didnt Know
Diagnosis of Viral myocarditis: Costs for treatment #211813 in Germany | BookingHealth
Done with brain MRI. Diagnosis of demyelinating disease. Suggestion?
DMOZ - Health: Conditions and Diseases: Neurological Disorders: Demyelinating Diseases: Multiple Sclerosis: Personal Pages
Altmetric - Intravenous immunoglobulin for presumed viral myocarditis in children and adults
Impaired Cytokine Response in Male ICR Swiss Mice After Infection With by Nancy J. Bigley, Roy A. Blay et al.
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. - MRC Weatherall Institute of Molecular...
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Neurochemical and Model Membrane Studies in Demyelinating Diseases | SpringerLink
Paul Lee, PA-C
Saffold virus
"Cardioviruses Are Genetically Diverse and Cause Common Enteric Infections in South Asian Children". Journal of Virology. 83 (9 ... a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLOS Pathogens. 5 (5): e1000416. doi: ... Discovered in 2007, it is the first human virus in the genus Cardiovirus and may provide a link to the development of multiple ... A poly(A) is located on the 3'UTR side, and contained on the 5'UTR side are internal ribosome entry sites (IRES). Cardiovirus ...
Theiler's encephalomyelitis virus
... a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): e1000416. doi: ... Infection initiates in astrocytes and microglia, but persists in macrophages. This strain has been used as an acceptable model ... This is the proposed course of disease in TMEV infection in mice. Many bacteria and viruses infect humans without pathology in ... The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. As SJL/J mice are ...
Cardiovirus A
... is a member of the Picornaviridae family. Infection with the virus causes encephalomyocarditis and reproductive ...
Picornain 3C
3C and 3D act similarly in rhinovirus as they do in poliovirus because they are both involved in early viral infection of the ... Picornain 3C is encoded by enteroviruses, rhinoviruses, aphtoviruses and cardioviruses. These genera of picoviruses cause a ... Coxsackievirus is shed through stool and bodily fluids and is prevalent in children but can infection occur in adults. Symptoms ... A small amount of poliovirus infections cause paralysis when the virus infects the nervous system. Poliovirus infects host ...
List of MeSH codes (C02)
... cardiovirus infections MeSH C02.782.687.207 - common cold MeSH C02.782.687.359 - enterovirus infections MeSH C02.782.687.359. ... deltaretrovirus infections MeSH C02.782.815.200.260 - enzootic bovine leukosis MeSH C02.782.815.200.470 - htlv-i infections ... avulavirus infections MeSH C02.782.580.600.080.600 - newcastle disease MeSH C02.782.580.600.400 - henipavirus infections MeSH ... respiratory syncytial virus infections MeSH C02.782.580.600.680 - rubulavirus infections MeSH C02.782.580.600.680.500 - mumps ...
Picornavirus
The whole of replication occurs within the host cell cytoplasm and infection can even happen in cells that do not contain a ... Notable examples are genera Enterovirus (including Rhinovirus and Poliovirus), Aphthovirus, Cardiovirus, and Hepatovirus. The ... However, as little as 30 minutes after initial infection, cell protein synthesis declines to almost zero output - essentially ... and that is the reason why rhinovirus infections are restricted to the nose and throat. The following genera are recognized: ...
Bat virome
Aditi; Shariff, M. (2019). "Nipah virus infection: A review". Epidemiology and Infection. 147: e95. doi:10.1017/ ... Several genera of picornaviruses have been found in bats, including Kobuvirus, Sapelovirus, Cardiovirus, and Senecavirus. ... In late 2012, a vaccine was released to prevent infection in horses. Vaccine uptake has been low, with an estimated 11-17% of ... Bats' immune systems may have evolved to be more tolerant of stressors such as viral infections compared to other mammals. The ...
Mengovirus
There is no specific treatment for a Mengovirus infection; although Persantine has been shown to inhibit its replication. The ... belongs to the genus Cardiovirus which is a member of the Picornaviridae. Its genome is a single stranded positive-sense RNA ...
Erbovirus
The low serum antibody response of ERBV appears to allow the continual, seasonal re-infection of horses. Horses are also known ... relationship to each other and to aphthoviruses and cardioviruses". J Gen Virol. 77 ( Pt 8) (8): 1719-30. doi:10.1099/0022-1317 ...
Virus classification
Satellites depend on co-infection of a host cell with a helper virus for productive multiplication. Their nucleic acids have ... Enterovirus, rhinovirus, hepatovirus, cardiovirus, aphthovirus, poliovirus, parechovirus, erbovirus, kobuvirus, teschovirus, ...
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection<...
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. / Komuro, Akihiko; Homma, Yuya ... The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochemical and biophysical ... title = "The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection", ... T1 - The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection ...
Figure 1 - Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China - Volume 16,...
We detected SAFV in 7 (0.5%) patients and identified lineages 1-3. However, because 3 patients had co-infections, we could not ... To clarify the potential for respiratory transmission of Saffold cardiovirus (SAFV) and characterize the pathogen, we analyzed ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China Lili Ren, Richard Gonzalez, ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China. ...
New Saffold Cardiovirus in Children, China - Volume 15, Number 6-June 2009 - Emerging Infectious Diseases journal - CDC
... these have been considered the first documented reports of cardiovirus infection in humans (1-4). However, the epidemiologic ... Drexler JF, Luna LK, Stöcker A, Almeida PS, Ribeiro TC, Petersen N, Circulation of 3 lineages of a novel Saffold cardiovirus in ... Chiu CY, Greninger AL, Kanada K, Kwok T, Fischer KF, Runckel C, Identification of cardioviruses related to Theilers murine ... New Saffold cardioviruses in 3 children, Canada. Emerg Infect Dis. 2008;14:834-6. DOIPubMed ...
Toll-like receptor 3 promotes cross-priming to virus-infected cells
Japanese Journal of Infectious Diseases Page 9
Saffold cardiovirus infection in a 2-year-old boy with acute pancreatitis.. This report presents a unique case which developed ... Abstract The urinary tract infection (UTI) is one of the most common infections in human, primarily caused by uropathogenic ... Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report.. PMID ... High Rates of Hepatitis B, Hepatitis C and Human Immunodeficiency Virus (HBV, HCV, HIV) Infections and Their Uncommon HBV ...
Welcome to CDC stacks | Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans - 17307 | Emerging Infectious...
Cardiovirus Cardiovirus Infections Child Child, Preschool Feces Gastroenteritis Germany Humans Infant Infant, Newborn Middle ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China ... The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause ... Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We ...
Theiler's encephalomyelitis virus - Wikipedia
... a Human Theilers-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): e1000416. doi: ... Infection initiates in astrocytes and microglia, but persists in macrophages. This strain has been used as an acceptable model ... This is the proposed course of disease in TMEV infection in mice. Many bacteria and viruses infect humans without pathology in ... The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. As SJL/J mice are ...
Saffold virus - Wikipedia
"Cardioviruses Are Genetically Diverse and Cause Common Enteric Infections in South Asian Children". Journal of Virology. 83 (9 ... a Human Theilers-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLOS Pathogens. 5 (5): e1000416. doi: ... Discovered in 2007, it is the first human virus in the genus Cardiovirus and may provide a link to the development of multiple ... A poly(A) is located on the 3UTR side, and contained on the 5UTR side are internal ribosome entry sites (IRES). Cardiovirus ...
METHOHDS OF INHIBITING VIRAL INFECTION - FUNCTIONAL GENETICS, INC.
A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one ... Hepatovirus, Cardiovirus,. Aphthovirus, Parechovirus,. Erbovirus, Kobuvirus, Teschovirus. 3.. Caliciviridae. Norwalk virus, ... for administration to a human or animal experiencing a viral infection or at risk of a viral infection. Such pharmaceutical ... The infection pathway and timing of RSV is well known, and is set forth in the lower right corner. As can be seen, at any time ...
McNair Scholars Undergraduate Research Journal
Immunodepletion of inflammatory monocytes preserves cog | Open-i
Cardiovirus Infections/immunology/pathology*. *Hippocampus/immunology/pathology*/virology. *Monocytes/immunology/pathology*/ ... Bottom Line: Identification of the immune effectors responsible for injuring the brain during acute infection is necessary for ... Bottom Line: Identification of the immune effectors responsible for injuring the brain during acute infection is necessary for ... Background: Neuropathology caused by acute viral infection of the brain is associated with the development of persistent ...
Calcaneal bone redness and Infection - Symptom Checker - check medical symptoms at RightDiagnosis
List of causes of Calcaneal bone redness and Infection, alternative diagnoses, rare causes, misdiagnoses, patient stories, and ... Cardiovirus. 192. Caroli Disease. 193. Cartilaginous -- arthritic -- ophthalmic -- deafness syndrome. 194. Caterpillar ... Shigella boydii infection. 1071. Shigella dysenteriae infection. 1072. Shigella flexneri. 1073. Shigella flexneri infection. ... Gnathostoma Infection. 466. Gnathostoma hispidum infection. 467. Gnathostoma spinigerum infection. 468. Gonococcal urethritis. ...
Welcome to the DeRisi Lab
Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections.. Chiu CY, Greninger AL ... Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children.. Chiu CY, Urisman A, ... Pan-Viral Screening of Respiratory Tract Infections in Adults with and without Asthma Reveals Unexpected Diversity. Amy Kistler ... Splenic Red Pulp Macrophages Produce Type I Interferons as Early Sentinels of Malaria Infection... Charles C. Kim, Christopher ...
Using a Pan-Viral Microarray Assay (Virochip) to Screen Clinical Samples for Viral Pathogens | Protocol
Chiu, C. Y. Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections. Proc Natl ... Immunology and Infection Using a Pan-Viral Microarray Assay (Virochip) to Screen Clinical Samples for Viral Pathogens. doi: ... Chiu, C. Y. Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children. J Pediatr. ... Kistler, A. Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human ...
Cardiovirus | definition of Cardiovirus by Medical dictionary
Cardiovirus explanation free. What is Cardiovirus? Meaning of Cardiovirus medical term. What does Cardiovirus mean? ... Looking for online definition of Cardiovirus in the Medical Dictionary? ... Six genera are associated with human infections: cardiovirus (saffold virus), cosavirus, enterovirus (EV), hepatovirus ( ... Circulation of three lineages of a novel Saffold cardiovirus in humans.. Seroepidemiology of saffold cardiovirus type 2 ...
Citation tools | Journal of Virology
Julie Parsonnet | Stanford Medicine Profiles
Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections PROCEEDINGS OF THE ... pylori infection, when compared with CagA(-) infection or the absence of H. pylori infection, is associated with a higher ... Maternal infection with Helicobacter pylori as a risk factor for infection in children of different ages Tamburini, B. A., Tsai ... THE INCIDENCE OF HELICOBACTER-PYLORI INFECTION Roundtable Meeting on Epidemiology of Helicobacter pylori Infection Parsonnet, J ...
The Fecal Viral Flora of Wild Rodents | proLékaře.cz
BlinkovaOKapoorAVictoriaJJonesMWolfeN 2009 Cardioviruses are genetically diverse and cause common enteric infections in South ... Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections. Proc Natl Acad Sci U S ... to the Saffold virus belonging to Cardiovirus genus. Similar to cardioviruses the 2A protein in Mosavirus had the conserved ... prevalence of hantavirus infection in rodents associated with two fatal human infections in California. Am J Trop Med Hyg 52 ...
ASMscience | Recombination in the Evo
Cardioviruses are genetically diverse and cause common enteric infections in South Asian children. J. Virol. 83: 4631- 4641.. ... Detection of human rhinovirus C in children with acute lower respiratory tract infections in South Korea. Arch. Virol. 154: 987 ... Epidemiology and clinical associations of human parechovirus respiratory infections. J. Clin. Microbiol. 46: 3446- 3453.. ... Evidence of recombination and genetic diversity in human rhinoviruses in children with acute respiratory infection. PLoS One 4: ...
The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in...
RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochem Biophys Res Commun 480: 187-193 ... Backes S, Langlois RA, Schmid S, Varble A, Shim JV, Sachs D, tenOever BR (2014) The mammalian response to virus infection is ... Matskevich AA, Moelling K (2007) Dicer is involved in protection against influenza A virus infection. J Gen Virol 88: 2627-2635 ... HEK293 cells were transfected with FLAG‐LGP2 for 24 h followed by infection with EMCV at the indicated MOI for 6 h. Cells were ...
Welcome to CDC stacks
Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been ... Infections caused by enteroviruses (EV) and parechoviruses (PeV), members of the Picornaviridae family, are associated with ... We report a case of myocarditis associated with human parechovirus (HPeV) infection in an adult. HPeV is an emerging pathogen ... Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple ...
Picornaviruses and Apoptosis: Subversion of Cell Death | mBio
Notably, an increase in nuclear permeability is also seen in infection with cardioviruses, specifically encephalomyocarditis ... Together these results suggest that apoptosis is induced in response to PV infection but active PV infection is able to inhibit ... Infected cells can undergo apoptosis as a protective response to viral infection, thereby limiting viral infection. As viruses ... Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition. EMBO J20:240-249. doi: ...
Frontiers | Evolutionary and Structural Overview of Human Picornavirus Capsid Antibody Evasion | Cellular and Infection...
... response against the capsid protein represents the most active immune pressure and primary weapon to control the infection. ... response against the capsid protein represents the most active immune pressure and primary weapon to control the infection. ... 2016). Structure and genome release mechanism of the human cardiovirus saffold virus 3. J. Virol. 90, 7628-7639. doi: 10.1128/ ... Picornavirus cell infection starts with its attachment to cell receptors (Figure 2). Therefore, virus-receptor usage is ...
HuGE Navigator|Genopedia|PHGKB
Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus...
... a nonhuman pathogen belonging to the Cardiovirus genus of Picornaviridae. However, AUF1 does not negatively regulate infection ... Virus infections.293-shCtrl or -shAUF1 cells were infected with wild-type or Δ3′ NCR poliovirus at a multiplicity of infection ... 1A). Following infection by poliovirus at a multiplicity of infection (MOI) of 1, an approximately 10-fold increase in ... Proposed model for AUF1 negative regulation of poliovirus and CVB3 infection. Following poliovirus and CVB3 infection, ...
Mosaic Virus
Prevention and Control of Cardiovirus Infections Thu, 20 Jul 2017 , Mosaic Virus ... Viruses may cause acute infection (hepatitis A virus) or acute infection with the possibility for chronic liver infection ... Clinical Features of Enteric Infection. *Clinical Features of Infection - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 ... Industries Affected by Phage Infection Thu, 27 Apr 2017 , Mosaic Virus Reliable data on the severity of phage infection of ...
Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis...
The peak activity of HPeV infection was in fall. Of the 3 children with AiV infection, the 3 AiV strains were found to belong ... The epidemiology of HPeV, AiV and SalV infections was analyzed. Among 1,708 fecal samples subjected to RT-PCR using primers ... but their roles in enteric infections are not fully understood. In addition, no report on the circulation of these viruses in ... Identification of cardioviruses related to Theilers murine encephalomyelitis virus in human infections. Proc Natl Acad Sci U S ...
ASMscience | Theiler's Virus Central
... infection in the mouse, which is the virus natural host. The recent identification of SAFV infection as a frequent one in ... There are many features of cardioviruses, and especially TMEV, that make them attractive for pathogenesis studies, including ... Furthermore, the identification of the human SAFV indicates that efforts investigating the involvement of cardioviruses as a ... This chapter discusses members of the Cardiovirus genus and distinctive characteristics of these viruses. It focuses on the ...
Epidemiology2
- The concentration of viruses observed in urban sewage is high and is related to the epidemiology of each viral infection. (waterpathogens.org)
- Our study was part of a systematic prospective study to assess the epidemiology of respiratory virus infections in children admitted to the Severo Ochoa Hospital (Leganés, Madrid Province, Spain).We conducted a specific study to determine the incidence of respiratory virus infections in all infants admitted after ALTEs during November 2004-December 2008. (blogspot.com)
Virus3
- Mild histological and biochemical hepatitis developed in these animals and there was serological evidence of infection with the virus-like particle as shown by immunoelectronmicroscopy (IEM). (ias.ac.in)
- To assess whether infants hospitalized after an apparently life-threatening event had an associated respiratory virus infection, we analyzed nasopharyngeal aspirates from 16 patients. (blogspot.com)
- We assessed the relation between ALTEs and respiratory virus infection in a secondary hospital in Spain. (blogspot.com)
Study1
- The genera Cyclovirus have been suggested to cause human enteric infections and, a study identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. (waterpathogens.org)
Patients1
- Apparently life-threatening events (ALTEs) in infants are associated with bronchiolitis or infections in up to 6% of patients by diagnosis after hospital admission (5). (blogspot.com)