Cardiovirus: A genus of the family PICORNAVIRIDAE causing encephalitis and myocarditis in rodents. ENCEPHALOMYOCARDITIS VIRUS is the type species.Cardiovirus Infections: Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.Mengovirus: A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, isolated from rodents and lagomorphs and occasionally causing febrile illness in man.Encephalomyocarditis virus: The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.Picornaviridae: A family of small RNA viruses comprising some important pathogens of humans and animals. Transmission usually occurs mechanically. There are nine genera: APHTHOVIRUS; CARDIOVIRUS; ENTEROVIRUS; ERBOVIRUS; HEPATOVIRUS; KOBUVIRUS; PARECHOVIRUS; RHINOVIRUS; and TESCHOVIRUS.Theilovirus: A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.Maus Elberfeld virus: A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.National Academy of Sciences (U.S.): A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.Red Cross: International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.GermanyClassification: The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Indigo Carmine: Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.BooksVanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).Paeonia: A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.RNA Replicase: An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Poliomyelitis: An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)Aphthovirus: A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species.Microalgae: A non-taxonomic term for unicellular microscopic algae which are found in both freshwater and marine environments. Some authors consider DIATOMS; CYANOBACTERIA; HAPTOPHYTA; and DINOFLAGELLATES as part of microalgae, even though they are not algae.Spirulina: A genus of filamentous CYANOBACTERIA found in most lakes and ponds. It has been used as a nutritional supplement particularly due to its high protein content.Lubricants: Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Polysaccharides, Bacterial: Polysaccharides found in bacteria and in capsules thereof.PolysaccharidesBiofuels: Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).Calcaneus: The largest of the TARSAL BONES which is situated at the lower and back part of the FOOT, forming the HEEL.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.ConjunctivitisErythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Cardiac Care Facilities: Institutions specializing in the care of patients with heart disorders.Cardiac Surgical Procedures: Surgery performed on the heart.Faculty: The teaching staff and members of the administrative staff having academic rank in an educational institution.Students: Individuals enrolled in a school or formal educational program.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

A new picornavirus isolated from bank voles (Clethrionomys glareolus). (1/32)

A previously unknown picornavirus was isolated from bank voles (Clethrionomys glareolus). Electron microscopy images and sequence data of the prototype isolate, named Ljungan virus, showed that it is a picornavirus. The amino acid sequences of predicted Ljungan virus capsid proteins VP2 and VP3 were closely related to the human pathogen echovirus 22 (approximately 70% similarity). A partial 5' noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype.  (+info)

A coding RNA sequence acts as a replication signal in cardioviruses. (2/32)

Theiler's virus and Mengo virus are representatives of the Cardiovirus genus within the picornavirus family. Their genome is an 8-kilobase long positive strand RNA molecule. This RNA molecule plays three roles in infected cells: It serves as a messenger RNA, acts as a template for genome replication, and is encapsidated to form progeny virions. We observed that a cis-acting signal required for replication of Theiler's virus was contained within a 130-nt stretch of the region encoding the capsid protein VP2. This RNA sequence does not influence internal ribosome entry site-mediated translation initiation and thus likely acts directly as a signal for the replication complex. We found a similar signal in the VP2-coding sequence of Mengo virus, and both signals could be functionally exchanged. Within the replication element, a 9-nt sequence that is highly conserved among cardioviruses was shown to be essential for replication. This conserved sequence was contained in mostly unpaired regions of the RNA secondary structure predicted for the replication elements of the various cardioviruses. Interestingly, a similar replication element has been reported to occur in the distantly related human rhinovirus type 14, suggesting that such elements could be conserved throughout the picornavirus family. However, the different location of the replication elements in rhinovirus and cardioviruses, and the fact that they were not functionally exchangeable, is raising intriguing questions about the evolution of such signals in picornaviruses.  (+info)

Mechanisms of immunopathology in murine models of central nervous system demyelinating disease. (3/32)

Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reported to play important roles in myelin destruction. Numerous murine demyelinating models, both virus-induced and/or autoimmune, are available, which reflect the clinical and pathological variability seen in human disease. This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models.  (+info)

Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness. (4/32)

The leader (L) proteins encoded by picornaviruses of the genus Cardiovirus [Theiler's murine encephalomyelitis virus (TMEV) and Encephalomyocarditis virus (EMCV)] are small proteins thought to exert important functions in virus-host interactions. The L protein of persistent TMEV strains was shown to be dispensable for virus replication in vitro, but crucial for long-term persistence of the virus in the central nervous system of the mouse. The phenotype of chimeric viruses generated by exchanging the L-coding regions was analysed and it was shown that the L proteins of neurovirulent and persistent TMEV strains are functionally interchangeable in vitro and in vivo, despite the fact that L is the second most divergent protein encoded by these viruses after the L* protein. The L protein encoded by EMCV and Mengo virus (an EMCV strain) shares about 35 % amino acid identity with that of TMEV. It differs from the latter by lacking a serine/threonine-rich C-terminal domain and by carrying phosphorylated residues not conserved in the TMEV L protein. Our data show that, in spite of these differences, the L protein of Mengo virus shares, with that of TMEV, the ability to inhibit the transcription of type I interferon, cytokine and chemokine genes and to interfere with nucleocytoplasmic trafficking of host-cell proteins. Interestingly, analysis of viral RNA replication of the recombinant viruses raised the hypothesis that L proteins of TMEV and EMCV diverged during evolution to adapt to the different replication fitness of these viruses.  (+info)

Significance of the C-terminal amino acid residue in mengovirus RNA-dependent RNA polymerase. (5/32)

Replication of picornavirus genomes is accomplished by the virally encoded RNA-dependent RNA polymerase (RdRP). Although the primary structure of this enzyme exhibits a high level of conservation, there are several significant differences among different picornavirus genera. In particular, a comparative alignment indicates that the C-terminal sequences of cardiovirus RdRP (known also as 3D(pol)), are 1-amino-acid residue (arginine or tryptophan) longer than that of the enterovirus or rhinovirus enzymes. Here, it is shown that alterations of the last codon of the RdRP-encoding sequence of mengovirus RNA leading to deletion of the C-terminal Trp460 or its replacement by Ala or Phe dramatically impaired viral RNA replication and, in the former case, resulted in a quasi-infectious phenotype (i.e., the mutant RNA might generate a low yield of pseudorevertants acquiring a Tyr residue in place of the deleted Trp460). The replacement of Trp460 by His or Tyr did not appreciably alter the viral growth potential. Homology modeling of three-dimensional structure of mengovirus RdRP suggested that Trp460 may be involved in interaction between the thumb and palm domains of the enzyme. Specifically, Trp460 of the thumb may form a hydrogen bond with Thr219 and hydrophobically interact with Val216 of the palm. The proposed interactions were consistent with the results of in vivo SELEX experiment, which demonstrated that infectious virus could contain Ser or Thr at position 219 and hydrophobic Val, Leu, Ile, as well as Arg (whose side chain has a nonpolar part) at position 216. A similar thumb-palm domain interaction may be a general feature of several RdRPs and its possible functional significance is discussed.  (+info)

Crystallization and preliminary X-ray diffraction studies of Seneca Valley virus-001, a new member of the Picornaviridae family. (6/32)

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New Saffold cardioviruses in 3 children, Canada. (7/32)

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Circulation of 3 lineages of a novel Saffold cardiovirus in humans. (8/32)

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Cardiovirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Human and vertebrates serve as natural hosts. There are currently three species in this genus including the type species Cardiovirus A. Diseases associated with this genus include: myocarditis. Cardiovirus A has only one serotype, while Cardiovirus B consists of four viruses which are probably serologically distinct; these are Theilers Murine encephalomyelitis virus (TMEV), Vilyuisk human encephalomyelitis virus (VHEV), a Theiler-like rat virus (TRV) (which has yet to be named) and Saffold virus (SAF-V). Group: ssRNA(+) Order: Picornavirales Family: Picornaviridae Genus: Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Viruses in Cardiovirus are non-enveloped, with icosahedral, Spherical, and Round geometries, and T=pseudo3 symmetry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 7.8kb in length. Viral replication is cytoplasmic. Entry into the host cell is achieved by ...
The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal fluid (CSF) samples from children ...
Virion. Morphology. The crystal structures of mengovirus (Cardiovirus A) and TMEV and Saffold virus 3 (Cardiovirus B) have been resolved [{Grant et al., 1992:1549565RJOHTXGrant et al., 1992, Three-dimensional structure of Theiler virus, Proceedings of the National Academy of Sciences, USA 89, 6, 2061-5RJOMREFKrishnaswamy and Rossmann 1990:2156078RJOHTXKrishnaswamy and Rossmann 1990, Structural refinement and analysis of Mengo virus, J Mol Biol, 211, 4, 803-44}]. Empty capsids are seen only rarely, if ever. When compared by mean wall thickness, surface unevenness, and chain length of the major proteins, the cardiovirus capsid is intermediate between the enteroviruses and aphthoviruses. In place of a continuous, circular canyon seen in enteroviruses, is a five-fold repeated pit. There is no pocket factor.. Physicochemical and physical properties. Virion buoyant density in CsCl is 1.33-1.34 g cm-3. Virions are moderately stable to acidic pH.. Nucleic acid. Length of genome [{Bae et al., ...
The Cardiovirus genus is divided into two species: the Encephalomyocarditis species, which includes encephalomyocarditis virus (EMCV) and mengovirus, and the Theilovirus species, which includes Theilers murine encephalomyelitis virus (TMEV), Vilyuisk human encephalomyelitis virus (VHEV), and Saffold virus (SAFV). This chapter discusses members of the Cardiovirus genus and distinctive characteristics of these viruses. It focuses on the pathogenesis of TMEV-induced disease because of the extensive investigations of this topic as well as the remarkable ability of this virus to establish lifelong infection of the central nervous system (CNS) and to produce an immune-mediated demyelinating disease. There are many features of cardioviruses, and especially TMEV, that make them attractive for pathogenesis studies, including the following: the unusual and rather unique characteristics of TMEV strains and TMEV-induced diseases (neurovirulent versus persistent strains, acute versus chronic disease, virus-induced
All opinions are my own and do not represent medical advice or the views of any institution.. All graphics made by me are free-to-use. Please just cite the particular page, blog and me. A heads-up would be nice, but that can happen later.. ...
Cobalamin (vitamin B12) deficiency occurs with several disorders, involving different organs and systems, including blood, bowel, nervous system and eyes. Although the most important features are usually haematological ones, presence of neurological involvement, in the absence of blood count alterations, has just been described in the literature. Here we report the case of a 48-year-old man, suffering from coeliac disease for approximately 5 years, vegetarian, who was admitted to our department, referring dysaesthesia of the left lower limb, decreased libido and erectile dysfunction. Vitamin B12 deficiency was proved, even in the absence of blood count alteration, and treated with a vitamin supplement, resulting in complete remission. ...
Chemical compounds found in marijuana can help treat multiple sclerosis-like diseases in mice by preventing inflammation in the brain and spinal cord, a study finds.
Looking for online definition of Cardiovirus in the Medical Dictionary? Cardiovirus explanation free. What is Cardiovirus? Meaning of Cardiovirus medical term. What does Cardiovirus mean?
The graduate dean invites all graduate faculty to attend the final oral examinations for the doctoral candidates scheduled as follows:. Shiri Dori-Hacohen, Ph.D., Computer Science. Monday, April 10, 9 a.m., 203 Computer Science Building. Dissertation: "Controversy Detection and Analysis." James Allan, chr.. Amy Ryan, Ph.D., Neuroscience and Behavior. Monday, April 10, 1:30 p.m., N423 Tobin Hall. Dissertation: "The Effects of Predictability on Stereotypic Behavior in Typical Adult Humans (Homo Sapiens) and Rhesus Macaques (Macaca Mulatta)." Melinda Novak and Brian Lickel, co-chrs.. Gregory De Wet, Ph.D., Geosciences. Monday, April 10, 2:30 p.m., 129 Morrill II, Morrill Science Center. Dissertation: "Arctic and North Atlantic Paleo-Environmental Reconstructions from Lake Sediments." Raymond Bradley and Isla Castaneda, co-chrs.. Jacinta Renee Saffold, Ph.D., Afro-American Studies. Tuesday, April 11, 2:30 p.m., 601 Herter. Dissertation: "Stories Written on Concrete: Understanding and (Re) Imaging ...
The only previous MAC player taken fifth overall was Buffalo Khalil Mack, who went to Oakland in 2014 and is now the reigning NFL defensive player of the year.. Obviously, we play a lot of really good pass rushers and our objective is to keep No. Saffold describes his relationship with the Rams new veteran linemen as telepathic.. The marketer said in October that it was testing early versions of four different potential approaches, some with celebrities and some without, some related to football more than others, all emphasizing the year round availability of the product. What Is the Starting Salary for an ESPN Sports Commentator? by Jonathan Lister ; Updated September 26, 2017 The starting salary of an ESPN commentator depends largely on name, personality and experience in the field. The Dolphins had a chance to tie the game at 17 in the third quarter. Would be too confusing to many of the voters and that would not be fair to do to them. There are some around Allen Park who were impressed with ...
Pattern recognition receptors (PRRs) are crucial for responses to infections and tissue damage; however, their role in autoimmunity is less clear. Herein we demonstrate that 2 C-type lectin receptors (CLRs) Mcl and Mincle play an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Congenic rats expressing lower levels of Mcl and Mincle on myeloid cells exhibited a drastic reduction in EAE incidence. In vivo silencing of Mcl and Mincle or blockade of their endogenous ligand SAP130 revealed that these receptors expression in the central nervous system is crucial for T cell recruitment and reactivation into a pathogenic Th17/GM-CSF phenotype. Consistent with this, we uncovered MCL- and MINCLE-expressing cells in brain lesions of MS patients and we further found an upregulation of the MCL/MINCLE signaling pathway and an increased response following MCL/MINCLE stimulation in peripheral blood mononuclear cells from MS ...
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA(~7.5kb) viruses with a 30 nm icosahedral capsid. Its genome does not have a lipid membrane. Picornaviruses are found in mammals and birds. There are currently 80 species in this family, divided among 35 genera. These include the Enterovirus, Aphthovirus, Cardiovirus, Rhinovirus and Hepatovirus genera. The viruses in this family can cause a range of diseases including paralysis, meningitis, hepatitis and poliomyelitis. Picornaviruses are in Baltimore IV class. Their genome single-stranded (+) sense RNA is that functions as mRNA after entry into the cell and all viral mRNA synthesized is of genome polarity. The mRNA encodes RNA dependent RNA polymerase. This polymerase makes complementary minus strands of RNA, then uses ...
Historical records from ancient China and Greece suggest that preparations of Cannabis indica were commonly prescribed to ameliorate multiple sclerosis-like symptoms such as tremors and muscle pain. Modern research has confirmed these effects in a study on diseased mice, wherein both endogenous and exogenous agonists showed ameliorating effects on tremor and spasticity. It remains to be seen whether pharmaceutical preparations such as dronabinol have the same effects in humans.[47][48] Due to increasing use of medical Cannabis and rising incidence of multiple sclerosis patients who self-medicate with the drug, there has been much interest in exploiting the endocannabinoid system in the cerebellum to provide a legal and effective relief.[35] In mouse models of multiple sclerosis, there is a profound reduction and reorganization of CB1receptors in the cerebellum.[49] Serial sections of cerebellar tissue subjected toimmunohistochemistry revealed that this aberrant expression occurred during the ...
In article ,ilena-1412961443180001 at max-lj-209.connectnet.com,, ilena at connectnet.com (Ilena Rose) wrote: , BREAST IMPLANTS: A NOVEL NEUROLOGICAL DISEASE WITH , , RHEUMATOLOGICAL SYMPTOMS. , , Britta Ostermeyer Shoaib and Bernard M. Patten. , Houston, Tex 77030. , , Twenty-six women developed a systemic disease with central , nervous system involvement at a mean age of 38 years (range 21-64 , years) after receiving silicone breast implants (n=25) or fluid , injections into breasts (n=1). Another classic from the esteemed team of Patten and Ostermeyer, scientists who are so far ahead of their peers that they need not bother with control groups, non-biased selection, or other inconveniences under which lesser minds feel compelled to labor. Ed _____________________________________________________ Ed Uthman, MD ,uthman at neosoft.com, Nemo liber est qui ,http://www.neosoft.com/~uthman/, corpore servit. Pathologist -Seneca Houston/Richmond, Texas, USA ...
The present study aimed to orally deliver methylthioadenosine (MTA) to the brain employing solid lipid nanoparticles (SLNs) for the management of neurological conditions like multiple sclerosis. The stearic acid-based SLNs were below 100 nm with almost neutral zeta potential and offered higher drug entrapment and drug loading. Cuprizone-induced demyelination model in mice was employed to mimic the multiple sclerosis-like conditions. It was observed that the MTA-loaded SLNs were able to maintain the normal metabolism, locomotor activity, motor coordination, balancing, and grip strength of the rodents in substantially superior ways vis-à-vis plain MTA. Histopathological studies of the corpus callosum and its subsequent staining with myelin staining dye luxol fast blue proved the potential of MTA-loaded SLNs in the remyelination of neurons. The pharmacokinetic studies provided the evidences for improved bioavailability and enhanced bioresidence supporting the pharmacodynamic findings. The studies ...
Results The myocardium of 24-week-old uPAR-deficient mice displayed focal ischemic lesions with hypertrophy of cardiomyocytes, severe myofibril rarefaction and contraction band necrosis. At 24 weeks of age, interstitial and perivascular collagen deposition (Picrosirius red-positive area) and myofibroblast counts were significantly greater in myocardial tissue of uPAR-deficient mice than in wild-type littermates (both p,0.001). In 24-week-old uPAR-deficient mice, myocardial fibrosis was paralleled by endothelial cell apoptosis and reduced capillary density, as shown by a significant increase in the percentage of apoptotic endothelial cells and a significant decrease in microvessel counts compared with wild-type littermates (both p,0.001). Full-length uPAR expression was significantly downregulated in the stromal compartment of SSc myocardium compared with controls (p,0.001), especially in microvessels and fibroblasts. ...
Abstract: Background Diarrhea kills 2 million children worldwide each year, yet an etiological agent is not found in approximately 30?50% of cases. Picornaviral genera such as enterovirus, kobuvirus, cosavirus, parechovirus, hepatovirus, teschovirus, and cardiovirus have all been found in human and animal diarrhea. Modern technologies, especially deep sequencing, allow rapid, high-throughput screening of clinical samples such as stool for new infectious agents associated with human disease. Results A pool of 141 pediatric gastroenteritis samples that were previously found to be negative for known diarrheal viruses was subjected to pyrosequencing. From a total of 937,935 sequence reads, a collection of 849 reads distantly related to Aichi virus were assembled and found to comprise 75% of a novel picornavirus genome. The complete genome was subsequently cloned and found to share 52.3% nucleotide pairwise identity and 38.9% amino acid identity to Aichi virus. The low level of sequence identity ...
Jerez, J.A.; Pinto, A.A.; Koseki, I.; Abuhab, T.G.; Regina Rodrigues, M.A.L.; Grecchi, R., 1980: Characteristics of aphthovirus strains isolated from buffaloes (in Brazil)
Human parechoviruses (HPeV), previously designated as echovirus 22 and 23, belong to the Parechovirus genus within the Picornaviridae family and has been designated HPeV 1 and 2 respectively.1 The HPeV genome organization and disease spectrum are similar to other viruses in the Picornaviridae family. HPeV have been frequently associated with respiratory and gastrointestinal diseases in children and severe disease in neonates that includes sepsis, meningitis, encephalitis, and hepatitis.2 In Brazil, HPeV type 8 was first reported in a gastroenteritis outbreak, where 35 stool samples were analyzed and 16.1% were HPeV positive.3 Highlighting HPeV as etiology of respiratory infection, the authors report the case of a 2-year-old girl with signs and symptoms of sepsis-like illness which progressed to sepsis with pulmonary focus. She was admitted to the pediatric emergency unit in a tertiary care hospital in Southern Brazil, with previous history of rhinorrhea, otorrhea and fever for seven days, and ...
The most common viruses implicated in respiratory infections, and among the most prevalent and clinically important viral pathogens infecting humans, are those of the Picornaviridae family -- rhinoviruses and enteroviruses.
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Picornaviruses represent a very large virus family with respect to the number of members but one of the smallest in terms of virion size and genetic complexity. They include two major groups of human pathogens: enteroviruses and rhinoviruses. Enteroviruses are transient inhabitants of the human alimentary tract and may be isolated from the throat or lower intestine. Rhinoviruses are associated with the respiratory tract and isolated chiefly from the nose and throat. Less -common picornaviruses associated with human illness include hepatitis A virus, parechovirus, cardiovirus, and Aichi virus. Several genera of picornaviruses are also associated with -animal, plant, and insect disease. ...
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Urticaria. Close-up of urticaria (red) on a 1-year-old male patient following an episode of hand foot and mouth disease (HFMD). Urticaria, also known as nettle rash or hives, is a skin condition in which a rash of itchy wheals or lumps develops on the skin, usually on the trunk or limbs. The wheals appear in a matter of minutes and usually fade after a few hours. Urticaria most often occurs as an acute allergic response, triggered, for instance, by particular foods or drugs. It can also result from heat, cold, sunlight or, less frequently, other medical conditions like cancer. HFMD is caused by intestinal viruses of the picornaviridae family. - Stock Image C026/9180
Definition of Encephalomyocarditis virus with photos and pictures, translations, sample usage, and additional links for more information.
Within the Picornaviridae family there are twospecies that affect equids: the equine rhinitis A virus and the equine rhinitisB virus. These viruses, discovered in the 60s and 70s, were initially includedin the same genus called Rhinovirus,differentiating four groups according to their characteristics: equine rhinovirus-1,equine rhinovirus-2, equine rhinovirus-3 and acid-stable equine picornavirus. Laterthe equine rhinovirus type 1 was renamed Equine Rhinitis A Virus (ERAV) beingclassified within the genus Aphthovirus,the other three were included in a new genus called Erbovirus, considering three serotypes of Equine Rhinitis B Virus(ERBV-1, ERBV -2 and ERBV-3). They are viruses with single-stranded RNA and theviral particles have a size of about 30 nm in diameter.
Rhinoviruses (RVs) are members of the Picornaviridae family, which includes the human pathogens enterovirus and hepatovirus (notably, hepatitis A virus). More than 100 different subtypes exist in 3 major groups, categorized according to receptor specificity: intercellular adhesion molecule-1 (ICAM-1), low-density lipoprotein (LDL) receptors, ...
Previous studies suggest that Lebers hereditary optic neuropathy (LHON) may be a systemic disorder with manifestations in organs other than the optic nerves. To evaluate nervous system involvement 38 men and eight women with LHON were re-examined. The patients were divided into three groups according to mtDNA analysis--namely, patients with the 11778 or with the 3460 mutation and patients without these primary mutations. Fifty nine per cent of patients had neurological abnormalities but there was no significant difference between the three groups. Movement disorders were the most common finding; nine patients had constant postural tremor, one chronic motor tic disorder, and one parkinsonism with dystonia. Four patients had peripheral neuropathy with no other evident cause. Two patients had a multiple sclerosis-like syndrome; in both patients MRI showed changes in the periventricular white matter. Thoracic kyphosis occurred in seven patients, five of whom had the 3460 mutation. In one patient ...
A coxsackie virus is a virus in the Picornaviridae family, which can cause symptoms like nausea, diarrhea, cramps, rashes, and...
Genus Cardiovirus. *Genus Cosavirus. *Genus Crohivirus. *Genus Dicipivirus. *Genus Enterovirus, mit Species Coxsackie-Virus, ...
Discovered in 2007, it is the first human virus in the Cardiovirus genus and may provide a link to the development of multiple ... This is the first human virus in the Cardiovirus family. Found to occur in high prevalence (>90%) among humans, by analogy SAFV ... Nine strains of SAFV have been identified; these are named SAFV-1 through to SAFV-9. Cardiovirus Picornaviridae Kirkegaard, ... "Saffold Virus, a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): ...
Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Genus: Cosavirus Cosavirus A Genus: Dicipivirus Cadicivirus A Genus: ... These include the Enterovirus, Aphthovirus, Cardiovirus, Rhinovirus and Hepatovirus genera. The viruses in this family can ...
Cardiovirus cis-acting replication element (CRE) Citrus tristeza virus replication signal Raman, S; Bouma P; Williams GD; Brian ...
Monoclonal Antibodies Against Cardiovirus Proteins is a technology that uses an antibody against encephalomyocarditis virus, ... Ann Palmenberg and her colleagues developed the antibody, which is used to recognize the cardiovirus using such techniques as ... Duke GM, Palmenberg AC (1989). "Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts ...
... is encoded by enteroviruses, rhinoviruses, aphtoviruses and cardioviruses. These genera all cause a wide range of ...
"Saffold Virus, a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): ... Theiler's Murine Encephalomyelitis Virus (TMEV) is a single-stranded RNA murine cardiovirus from the family Picornaviridae. It ...
A cardiovirus, EMCV, and an apthovirus, foot-and-mouth disease virus (FMDV) share about 50% identical IRES elements. HCV-like ...
... relationship to each other and to aphthoviruses and cardioviruses". J Gen Virol. 77 ( Pt 8) (8): 1719-30. doi:10.1099/0022-1317 ...
... also has non-medicinal uses in a laboratory context, such as the inhibition of cardiovirus growth in cell culture ...
Cardiovirus cis-acting replication element (CRE) Coronavirus SL-III cis-acting replication element (CRE) Heron HBV RNA ...
... belongs to the genus Cardiovirus which is a member of the Picornaviridae. Its genome is a single stranded positive-sense RNA ...
... and cardioviruses. Bazan, J.F.; Fletterick, R.J. (1988). "Viral cysteine proteases are homologous to the trypsin-like family of ...
Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Genus: Cosavirus Cosavirus A Genus: Dicipivirus Cadicivirus A Genus: ...
While the sequence of SVV's protein-coding genome is most similar to members in the Cardiovirus genus, the non-coding RNA ...
... cloverleaf cis-acting replication element Cardiovirus cis-acting replication element (CRE) Coronavirus SL-III cis-acting ...
... cardiovirus MeSH B04.820.565.170.200 --- encephalomyocarditis virus MeSH B04.820.565.170.200.150 --- Columbia sk virus MeSH ... cardiovirus MeSH B04.909.777.618.170.200 --- encephalomyocarditis virus MeSH B04.909.777.618.170.200.150 --- Columbia sk virus ...
C2likevirus C5likevirus Cafeteriavirus Capillovirus Capripoxvirus Cardiovirus Cardoreovirus Carlavirus Carmovirus Caulimovirus ...
... cardiovirus infections MeSH C02.782.687.207 --- common cold MeSH C02.782.687.359 --- enterovirus infections MeSH C02.782. ...
Cardamom mosaic virus Cardiochiles nigriceps bracovirus Cardioderma cor polyomavirus 1 Cardiovirus A Cardiovirus B Cardiovirus ...
... A Cardiovirus B Cardiovirus C Viruses in Cardiovirus are non-enveloped, with icosahedral, Spherical, ... Cardiovirus A has only one serotype, while Cardiovirus B consists of four viruses which are probably serologically distinct; ... Replication of cardioviruses is dependent on a structured RNA element called the Cardiovirus cis-acting replication element ( ... Cardiovirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Human and vertebrates serve as ...
... is a member of the Picornaviridae family. Infection with the virus causes encephalomyocarditis and reproductive ...
... is a species in the Cardiovirus genus and is represented by two isolates, Saffold virus (SAFV) and Theiler's ...
This family represents a Cardiovirus cis-acting replication element (CRE) which is located within the region encoding the ... Page for Cardiovirus cis-acting replication element (CRE) at Rfam. ... "A coding RNA sequence acts as a replication signal in cardioviruses". Proc Natl Acad Sci USA. 96 (20): 11560-11565. doi:10.1073 ...
Cardiovirus Cardiovirus A Cardiovirus B Cardiovirus C Viruses in Cardiovirus are non-enveloped, with icosahedral, Spherical, ... Cardiovirus A has only one serotype, while Cardiovirus B consists of four viruses which are probably serologically distinct; ... Replication of cardioviruses is dependent on a structured RNA element called the Cardiovirus cis-acting replication element ( ... Cardiovirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Human and vertebrates serve as ...
Cardiovirus A is a member of the Picornaviridae family. Infection with the virus causes encephalomyocarditis and reproductive ...
Cardiovirus B is a species in the Cardiovirus genus and is represented by two isolates, Saffold virus (SAFV) and Theilers ...
This family represents a Cardiovirus cis-acting replication element (CRE) which is located within the region encoding the ... Page for Cardiovirus cis-acting replication element (CRE) at Rfam. ... "A coding RNA sequence acts as a replication signal in cardioviruses". Proc Natl Acad Sci USA. 96 (20): 11560-11565. doi:10.1073 ...
Cardiovirus explanation free. What is Cardiovirus? Meaning of Cardiovirus medical term. What does Cardiovirus mean? ... Looking for online definition of Cardiovirus in the Medical Dictionary? ... Circulation of three lineages of a novel Saffold cardiovirus in humans.. Seroepidemiology of saffold cardiovirus type 2 ... Cardiovirus , definition of Cardiovirus by Medical dictionary https://medical-dictionary.thefreedictionary.com/Cardiovirus ...
Ren L, Gonzalez R, Xiao Y, Xu X, Chen L, Vernet G, Saffold cardiovirus in children with acute gastroenteritis, Beijing, China. ... Drexler JF, Luna LK, Stöcker A, Almeida PS, Ribeiro TC, Petersen N, Circulation of 3 lineages of a novel Saffold cardiovirus in ... Itagaki T, Abiko C, Ikeda T, Aoki Y, Seto J, Mizuta K, Sequence and phylogenetic analyses of Saffold cardiovirus from children ... Blinkova O, Kapoor A, Victoria J, Jones M, Wolfe N, Naeem A, Cardioviruses are genetically diverse and cause common enteric ...
Cardiovirus Cardiovirus Infections Child Child, Preschool Feces Gastroenteritis Germany Humans Infant Infant, Newborn Middle ... The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause ... Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China ...
Boone cardioviruses were detected in specimens of rats. Cardiovirus infection does not cause cleavage of the host eIF-4G. The ... The crystal structures of mengovirus (Cardiovirus A) and TMEV and Saffold virus 3 (Cardiovirus B) have been resolved [{Grant et ... The orthologous 2A protein of Boone cardioviruses (Cardiovirus C) is shorter (127 aa) and lacks an NPG↓P motif. ... The cardiovirus L protein is a unique picornavirus protein with Zn-finger domain (C-x-H-x6-C-x2-C) playing key roles in (i) the ...
... Mullapudi, Edukondalu Masaryk Univ, Czech ... We address this gap in our current knowledge by studying the uncoating of the nonenveloped human cardiovirus Saffold virus 3 ( ... Furthermore, in native conditions many cardioviruses contain a disulfide bond formed by cysteines that are separated by just ...
Cardiovirus Cardiovirus Infections Child Child, Preschool Epidemiology Finland Genotype HeLa Cells Humans Indonesia Infant ... The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause ... In Canada, cardiovirus isolates related to Saffold virus were detected in nasopharyngeal aspirates from 3 children with ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China ...
Genus Cardiovirus. *Genus Cosavirus. *Genus Crohivirus. *Genus Dicipivirus. *Genus Enterovirus, mit Species Coxsackie-Virus, ...
Buy the Other Book Virus Taxonomy by Andrew MQ King at Indigo.ca, Canadas largest bookstore. + Get Free Shipping on books over $25!
Cardiovirus Cardiovirus Infections Child Child, Preschool Children China Dispatch Feces Gastroenteritis Humans Infant Infant, ... The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause ... To understand Saffold cardiovirus (SAFV) distribution, prevalence, and clinical relevance in China, we retrospectively studied ... Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China ...
Drexler JF, Luna LK, Stöcker A, Almeida PS, Ribeiro TC, Petersen N, Circulation of 3 lineages of a novel Saffold cardiovirus in ... Chiu CY, Greninger AL, Kanada K, Kwok T, Fischer KF, Runckel C, Identification of cardioviruses related to Theilers murine ... New Saffold cardioviruses in 3 children, Canada. Emerg Infect Dis. 2008;14:834-6. DOIPubMed ... New Saffold Cardiovirus in Children, China. Emerging Infectious Diseases. 2009;15(6):993-994. doi:10.3201/eid1506.090109.. ...
Cardiovirus/Picornaviridae; Orthomyxoviridae. MDCK. 0.19-0.48. [52]. C. polykrikoides. Flu-A and Flu-B; respiratory syncytial ...
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. / Komuro, Akihiko; Homma, Yuya ... The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochemical and biophysical ... siRNA knockdown experiments indicate that TRBP is important for Cardiovirus-triggered interferon responses, but TRBP is not ... siRNA knockdown experiments indicate that TRBP is important for Cardiovirus-triggered interferon responses, but TRBP is not ...
New Saffold Cardiovirus in Children, China Zi-qian Xu, Wei-Xia Cheng, Hong-Mei Qi, Shu-xian Cui, Yu Jin, and Zhao-jun Duan. ...
Cardiovirus. encephalomyocarditis virus. Vertebrates. Aphtovirus. foot-and-mouth disease virus O. Vertebrates. ...
To understand Saffold cardiovirus (SAFV) distribution, prevalence, and clinical relevance in China, we retrospectively studied ... Saffold Cardiovirus in Children with Acute Gastroenteritis, Beijing, China Lili Ren, Richard Gonzalez, Yan Xiao, Xiwei Xu, Lan ... Saffold Cardiovirus in Children with Acute Gastroenteritis, Beijing, China. ... Fecal samples positive for Saffold cardiovirus, Beijing, Peoples Republic of China, March 2006-November 2007* ...
To understand Saffold cardiovirus (SAFV) distribution, prevalence, and clinical relevance in China, we retrospectively studied ... Drexler JF, Luna LK, Stöcker A, Almeida PS, Ribeiro TC, Petersen N, Circulation of 3 lineages of a novel Saffold cardiovirus in ... Chiu CY, Greninger AL, Kanada K, Kwok T, Fischer KF, Runckel C, Identification of cardioviruses related to Theilers murine ... Blinkova O, Kapoor A, Victoria J, Jones M, Wolfe N, Naeem A, Cardioviruses are genetically diverse and common enteric ...
  • 2014) Genetic characterization of the Syr-Darya valley fever virus (SDVFV) (Picornaviridae, Cardiovirus) isolated from the blood of the patients and ticks Hyalomma as. (wikipedia.org)
  • In the case of Cardiovirus A, the virus can cause encephalitis and myocarditis, mostly in rodents, which are natural hosts. (wikipedia.org)
  • Mengo virus, another cardiovirus that shares the same serotype as EMCV, was isolated from the cerebrospinal fluid of a paralyzed rhesus macaque in 1948 ( 8 ). (asm.org)
  • When compared by mean wall thickness, surface unevenness, and chain length of the major proteins, the cardiovirus capsid is intermediate between the enteroviruses and aphthoviruses. (ictvonline.org)
  • Horvath, Curt M. / The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection . (elsevier.com)
  • Theiler's-like cardiovirus, is ubiquitous introduced to Madagascar suggests and causes infection early in life. (cdc.gov)
  • A) Cytopathic effects (round cells) observed 6 days after infection of rhesus monkey kidney (LLC-MK2) cells (second passage) with the Can112051-06 Saffold virus-like cardiovirus strain. (cdc.gov)
  • TMEV-like cardiovirus sequences (GenBank accession no. (cdc.gov)
  • Thus, the Theiler's-like cardiovirus ( 4 ). (cdc.gov)
  • Ann Palmenberg and her colleagues developed the antibody, which is used to recognize the cardiovirus using such techniques as ELISA and Immunoprecipitation. (wikipedia.org)
  • This enzyme catalyses the following chemical reaction: Selective cleavage of Tyr-Gly bond in picornavirus polyprotein This enzyme is coded by entero-, rhino-, aphto- and cardioviruses. (wikipedia.org)
  • Duke GM, Palmenberg AC (1989) Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts. (springer.com)
  • Over the past 10 years, the Peruvian National Tuberculosis (TB) Program, the National Reference Laboratory (NRL), Socios en Salud, and US partners have worked to strengthen the national TB laboratory network to support treatment of multidrug-resistant TB. (cdc.gov)
  • Dipyridamole also has non-medicinal uses in a laboratory context, such as the inhibition of cardiovirus growth in cell culture. (wikipedia.org)
  • The cardiovirus 2A protein contains an NPG↓P motif and additional domains facilitating nucleolar localization, rRNA binding, and inhibition of cap-dependent cellular mRNA translation. (ictvonline.org)
  • The orthologous 2A protein of Boone cardioviruses ( Cardiovirus C ) is shorter (127 aa) and lacks an NPG↓P motif. (ictvonline.org)
  • Frequent detection of highly diverse variants of cardiovirus , cosavirus, bocavirus, and circovirus in sewage samples collected in the United States. (thefreedictionary.com)
  • Blinkova O , Rosario K , Li L , Kapoor A , Slikas B , Bernardin F , Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States. (cdc.gov)