Tertiary Prevention: Measures aimed at providing appropriate supportive and rehabilitative services to minimize morbidity and maximize quality of life after a long-term disease or injury is present.Primary Prevention: Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.Secondary Prevention: The prevention of recurrences or exacerbations of a disease or complications of its therapy.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Lipid Regulating Agents: Substances that alter the metabolism of LIPIDS.Viola: A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Clofibrate: A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)France: A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Butylene Glycols: 4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.Historiography: The writing of history; the principles, theory, and history of historical writing; the product of historical writing. (Webster, 3d ed)Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Diuretics: Agents that promote the excretion of urine through their effects on kidney function.Fluid Shifts: Translocation of body fluids from one compartment to another, such as from the vascular to the interstitial compartments. Fluid shifts are associated with profound changes in vascular permeability and WATER-ELECTROLYTE IMBALANCE. The shift can also be from the lower body to the upper body as in conditions of weightlessness.Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Peptidyl-Dipeptidase A: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 18.104.22.168.Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Blood Glucose: Glucose in blood.Postprandial Period: The time frame after a meal or FOOD INTAKE.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Diabetes, Gestational: Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.Hyperglycemia: Abnormally high BLOOD GLUCOSE level.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.Biometry: The use of statistical and mathematical methods to analyze biological observations and phenomena.Blood Glucose Self-Monitoring: Self evaluation of whole blood glucose levels outside the clinical laboratory. A digital or battery-operated reflectance meter may be used. It has wide application in controlling unstable insulin-dependent diabetes.Acute Disease: Disease having a short and relatively severe course.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Egypt: A country in northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip, and the Red Sea north of Sudan, and includes the Asian Sinai Peninsula Its capital is Cairo.Liver Neoplasms: Tumors or cancer of the LIVER.Oncology Service, Hospital: The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.Schistosomiasis: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Snails: Marine, freshwater, or terrestrial mollusks of the class Gastropoda. Most have an enclosing spiral shell, and several genera harbor parasites pathogenic to man.
... in Primary and Secondary Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranian. Available from: http ... Majed M, Moradmand Badie S. A pilot double-blind randomised placebo-controlled trial of the effects of xed-dose combination ... undergo blood pressure measurements in 6 months regular intervals and are referred to secondary or tertiary medical centers for ... Cardiovascular disease prevention using fixed dose pharmacotherapy in Iran: updated meta-analyses and mortality estimation. ...
Boniface is one of Manitoba's two tertiary care centres. Patients are referred to the hospital by their doctors or clinics for ... The Institute was created as the Division of Cardiovascular Sciences in 1987 by Dr. Naranjan Dhalla. Its researchers have been ... The hospital also participates in clinical trials of research discoveries. St. Boniface Hospital is located near the Red and ... The Family Medicine Program is designed to encourage disease prevention and health maintenance. It also includes a palliative ...
The tertiary and quaternary structures of PTGS1 (COX-1) and PTGS2 (COX-2) enzymes are almost identical. Each subunit has three ... Jain S, Khuri FR, Shin DM (2004). "Prevention of head and neck cancer: current status and future prospects". Curr Probl Cancer ... Studies with human pharmacology and genetics, genetically manipulated rodents, and other animal models and randomized trials ... NSAIDs and Cardiovascular Risk Explained, According to Studies from the Perelman School of Medicine ...
Vincent's actively participates in a number of ongoing prevention and treatment trials including: the STAR study, the Prostate ... Approximately 20,000 cardiovascular procedures are performed for patients each year-including diagnostic and non-invasive ... Vincent's Medical Center Riverside is a 528-bed full service tertiary care Catholic hospital located in Jacksonville, Florida. ... Cancer Prevention Trial, The National Surgical Adjuvant Breast and Bowel Project (a national cooperative study with the ...
Squalene synthase inhibitors that have been investigated for use in the prevention of cardiovascular disease include ... The allylic cation generated is then attacked by the olefin of a second molecule of FPP, affording a tertiary carbocation. The ... Gibbs, Edwina (29 October 2007). "UPDATE 2-US FDA tells Takeda to stop some TAK-475 trials". Reuters. Retrieved 5 March 2013. " ... Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene ...
"Primary, Secondary, and Tertiary Prevention: Important in Certification and Practice". Fitzergald Health Education Associates, ... Their doctors are currently participating at the worldwide ongoing trial called "Valentine" which is used for treatment of re- ... Licensed Private hospitals in Kosovo are the following: Special Hospital for Cardiovascular Diseases "Intermed", Specialized ... Many tertiary health care services are mistakenly used instead of primary and secondary health care services from Kosovo ...
... and cardiovascular syphilis (10%). Without treatment, a third of infected people develop tertiary disease. People with tertiary ... The Centers for Disease Control and Prevention (CDC) states, "Correct and consistent use of latex condoms can reduce the risk ... The effectiveness of treatment with penicillin was confirmed in trials in 1943. Before the discovery and use of antibiotics in ... Tertiary syphilis may occur approximately 3 to 15 years after the initial infection, and may be divided into three different ...
tertiary source). June 2015, 6 (2): e24055. PMC 4592762. PMID 26448838. doi:10.5812/asjsm.6(2)2015.24055.. ... Accident Analysis and Prevention. 2010, 42 (6): 2149-2157. PMID 20728675. doi:10.1016/j.aap.2010.07.008.. ... Potential Adverse Cardiovascular Effects from Excessive Endurance Exercise. Mayo Clinic Proceedings. 2012, 87 (6): 587-595. PMC ... a systematic review of randomized control trials. Prev Chronic Dis. 2013, 10: E174. PMC 3809922. PMID 24157077. doi:10.5888/ ...
A number of agents have been studied for the secondary prevention of indicated preterm birth. Trials using low-dose aspirin, ... Tertiary interventions are aimed at women who are about to go into preterm labor, or rupture the membranes or bleed preterm. ... Cardiovascular complications may arise from the failure of the ductus arteriosus to close after birth: patent ductus arteriosus ... Caritis S, Rouse D (2006). "A randomized controlled trial of 17-hydroxyprogesterone caproate (17-OHPC) for the prevention of ...
In 2011 the Centers for Disease Control and Prevention applied the IOM standard to NHANES data on serum levels collected ... A systematic review and meta-analysis of randomized trials". Journal of Critical Care. 38: 109-114. doi:10.1016/j.jcrc.2016.10. ... It has also been thought to correlated with cardiovascular disease, type 1 diabetes, type 2 diabetes, and some cancers. ... most commonly kidney dialysis patients who have had tertiary hyperparathyroidism, but also to patients with primary ...
In 1942, Henry Ford Hospital became one of a few U.S. hospitals selected by the National Research Council as a trial site to ... Henry Ford Hospital (HFH) is an 877-bed tertiary care hospital, education and research complex at the western edge of the New ... asthma and cancer prevention. Much of Henry Ford Hospital research is translational in nature - from bench to bedside. To this ... cardiovascular surgery, neurology, neurosurgery, orthopedics, sports medicine, organ transplants, and treatment for prostate, ...
... or tertiary prevention efforts, or an employer can implement programs that have elements of multiple types of prevention. The ... wellness interventions performed on high-risk cardiovascular disease employees indicated that at the end of a six-month trial, ... Researchers from the Centers for Disease Control and Prevention studied strategies to prevent cardiovascular disease and found ... "Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American Heart Association ...
Enhancement of hippocampal BDNF was accompanied by increases in dendritic spine density on the secondary and tertiary dendrites ... and to their prevention and treatment. He has published more than 700 peer-reviewed articles in leading journals and books, and ... a randomized trial in young overweight women. Int. J. Obesity. 35: 714-727 Mattson MP (2015) What doesn't kill you… Scientific ... cardiovascular disease and neurodegenerative disorders. Animal studies performed in Dr. Mattson's Laboratory showed that ...
PreventionEdit. The evidence for the effectiveness of early interventions to prevent psychosis appeared inconclusive. ... The first clinical trial of antipsychotics (also commonly known as neuroleptics) for the treatment of psychosis took place in ... Tertiary brain cortex collects the interpretations from the secondary cortexes and creates a coherent world view of it. A study ... side-effect profile that included a lower risk of Parkinsonian symptoms but a higher risk of cardiovascular disease. ...
Wang, L (2010 Mar 2). "Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events". Annals ... It is a tertiary source on vitamin D. To contradict it in the article you need something more than a secondary source. ... Such a signal can be too difficult to see in short term double blind trials as Dr. Vieth points out. Also, you have to consider ... Cardiovascular disease. Evidence for health effects from vitamin D supplementation for cardiovascular health is poor. ...
... maintenance behaviors include illness prevention, illness behaviors, and proper hygiene. Illness prevention measures ... Havranek, E.P.; Mujahid, M.S.; Barr, D.A. (2015). "Social determinants of risk and outcomes for cardiovascular disease: A ... A randomized controlled trial". Journal of Consulting and Clinical Psychology. 75 (2): 336-343. doi:10.1037/0022-006x.75.2.336 ... or one's own health after discharge from secondary and tertiary health care. For instances of neck pain, for example, self-care ...
Tertiary preventionEdit. Finally, tertiary prevention attempts to reduce the damage caused by symptomatic disease by focusing ... "Primordial Prevention of Cardiovascular Disease". Circulation. 131 (7): 599-601. doi:10.1161/circulationaha.115.014849. PMC ... a cluster randomized controlled trial". Drugs: Education, Prevention and Policy. 21: 35-42. doi:10.3109/09687637.2013.798264.. ... Unlike secondary prevention, which aims to prevent disability, the objective of tertiary prevention is to maximize the ...
1908: "The Prevention of Compressed Air Illness" was published by JS Haldane, Boycott and Damant recommending staged ... Vann, Richard D; Gerth, Wayne A; DeNoble, Petar J; Pieper, Carl F; Thalmann, Edward D (2004). "Experimental trials to assess ... Protein molecules may be denatured by reorientation of the secondary and tertiary structure when non-polar groups protrude into ... cardiovascular disease, smoking, or body mass index. Increased depth, previous DCI, larger number of consecutive days diving, ...
"A Roadmap on the Prevention of Cardiovascular Disease Among People Living With Diabetes". Global Heart. 14 (3): 215-240. doi: ... Webster MW (July 2011). "Clinical practice and implications of recent diabetes trials". Current Opinion in Cardiology. 26 (4): ... Prevention. Main article: Prevention of type 2 diabetes. Onset of type 2 diabetes can be delayed or prevented through proper ... "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A ...
Mattick RP; Digiusto E; Doran C; O'Brien S; Kimber J; Henderson N; Breen B; Shearer J; Gates J; Shakeshaft A; NEPOD Trial ... Chan R, Irvine R, White J (1999). "Cardiovascular changes during morphine administration and spontaneous withdrawal in the rat ... Fisher, Gary L. (2009). Encyclopedia of substance abuse prevention, treatment, & recovery. Los Angeles: SAGE. p. 564. ISBN 978- ... tertiary amine function at position 17, 5 centers of chirality (C5, C6, C9, C13 and C14) with morphine exhibiting a high degree ...
It provides care for adult congenital heart disease patients, as well as cardiac imaging, cardiovascular and thoracic surgery, ... The Institute also promotes brain injury education and prevention. The Texas Legislature provided $15 million for the current ... tertiary, and long-term care. The 822-bed system has a Spinal Cord Injury Center, Domiciliary Care Program, and Community ... Medical Center also is home to an NIH Alzheimer's Disease Center and is a Network of Excellence in Neuroscience Clinical Trials ...
Malouf, Reem; Evans, John Grimley (8 October 2008). "Folic acid with or without vitamin B12 for the prevention and treatment of ... Neurobiol Aging 19, 173-189 Kolata, Gina (June 17, 2010). "Drug Trials Test Bold Plan to Slow Alzheimer's". The New York Times ... There is a possibility that people may experience an increase in cardiovascular-related events if these medications are ... "Percutaneous endoscopic gastrostomy complications in a tertiary-care center". Am Surg. 68 (2): 117-20. PMID 11842953. CS1 maint ...
2012). "The "House Calls" trial: a randomized controlled trial to reduce racial disparities in live donor kidney ... 2012). "The dangers of being a "weekend warrior": A new call for injury prevention efforts". The journal of trauma and acute ... cardiovascular, transplant, plastic and reconstructive, and minimally invasive surgery Beth Israel Deaconess Medical Center ( ... "Surgical Management of Acute Cholecystitis at a Tertiary Care Center in the Modern Era". Arch Surg. 145 (5): 439-44. doi: ...
"Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes ... Major clinical trials. The Diabetes Control and Complications Trial (DCCT) was a clinical study conducted by the United States ... Prevention. See also: Prevention of diabetes mellitus type 2. There is no known preventive measure for type 1 diabetes. Type ... cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis". JAMA Internal Medicine. ...
"Long-term Sustainability of Diabetes Prevention Approaches: A Systematic Review and Meta-analysis of Randomized Clinical Trials ... cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis". JAMA Internal Medicine. ... Prevention. Main article: Prevention of diabetes mellitus type 2. Onset of type 2 diabetes can be delayed or prevented through ... Prevention. Maintaining normal weight, exercising, eating properly. Treatment. Dietary changes, metformin, insulin, ...
The role of cholesterol in the development of cardiovascular disease was elucidated in the second half of the 20th century. This lipid hypothesis prompted attempts to reduce cardiovascular disease burden by lowering cholesterol. Treatment consisted mainly of dietary measures, such as a low-fat diet, and poorly tolerated medicines, such as clofibrate, cholestyramine, and nicotinic acid. Cholesterol researcher Daniel Steinberg writes that while the Coronary Primary Prevention Trial of 1984 demonstrated cholesterol lowering could significantly reduce the risk of heart attacks and angina, physicians, including cardiologists, remained largely unconvinced. Scientists in academic settings and the pharmaceutical industry began trying to develop a drug to reduce cholesterol more effectively. There were several potential targets, with 30 steps in the synthesis of cholesterol from acetyl-coenzyme A. In 1971, Akira Endo, a Japanese ...
... detects potential data breaches/data ex-filtration transmissions and prevents them by monitoring, detecting and blocking sensitive data while in-use (endpoint actions), in-motion (network traffic), and at-rest (data storage). The terms "data loss" and "data leak" are related and are often used interchangeably. Data loss incidents turn into data leak incidents in cases where media containing sensitive information is lost and subsequently acquired by an unauthorized party. However, a data leak is possible without losing the data on the originating side. Other terms associated with data leakage prevention are information leak detection and prevention (ILDP), information leak prevention (ILP), content monitoring and filtering (CMF), information protection and control (IPC) and extrusion prevention system (EPS), as opposed to intrusion ...
An HIV vaccine is a vaccine which would either protect individuals who do not have HIV from contracting that virus, or otherwise may have a therapeutic effect for persons who have or later contract HIV/AIDS. Currently, there is no effective HIV vaccine but many research projects managing clinical trials seek to create one. There is evidence that a vaccine may be possible. Preventative medications such as antiretroviral treatments have been put into use to help prevent infection, but do not work as well as a vaccine would. Work with monoclonal antibodies (MAb) has shown or proven that the human body can defend itself against HIV, and certain individuals remain asymptomatic for decades after HIV infection. Potential candidates for antibodies and early stage results from clinical trials have been announced. One HIV vaccine candidate which showed some efficacy was studied in RV 144, which was a trial in Thailand beginning in 2003 and first reporting a positive result in 2009. ...
... is a clinical approach to those experiencing symptoms of psychosis for the first time. It forms part of a new prevention paradigm for psychiatry and is leading to reform of mental health services, especially in the United Kingdom and Australia. This approach centers on the early detection and treatment of early symptoms of psychosis during the formative years of the psychotic condition. The first three to five years are believed by some to be a critical period. The aim is to reduce the usual delays to treatment for those in their first episode of psychosis. The provision of optimal treatments in these early years is thought to prevent relapses and reduce the long-term impact of the condition. It is considered a secondary prevention strategy. The duration of untreated psychosis (DUP) has been shown as an indicator of prognosis, with a longer DUP associated with more long term disability. There are a number of functional components of the ...
The Framingham Risk Score is a gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual. The Framingham Risk Score was first developed based on data obtained from the Framingham Heart Study, to estimate the 10-year risk of developing coronary heart disease. In order to assess the 10-year cardiovascular disease risk, cerebrovascular events, peripheral artery disease and heart failure were subsequently added as disease outcomes for the 2008 Framingham Risk Score, on top of coronary heart disease. The Framingham Risk Score is one of a number of scoring systems used to determine an individual's chances of developing cardiovascular disease. A number of these scoring systems are available online. Cardiovascular risk scoring systems give an estimate of the probability that a person will develop cardiovascular disease within a specified amount of time, usually 10 to 30 years. Because they give an ...
The National Cholesterol Education Program is a program managed by the National Heart, Lung and Blood Institute, a division of the National Institutes of Health. Its goal is to reduce increased cardiovascular disease rates due to hypercholesterolemia (elevated cholesterol levels) in the United States of America. The program has been running since 1985. The assigned goal of the NCEP committee is to meet on a recurring basis, review ongoing scientific research about atherosclerotic cardiovascular disease and make simplified, consensus, committee recommendations to be promoted by the NIH, the American Heart Association and other groups to both physicians and the public about how to reduce the incidence of disability and death resulting from atherosclerotic cardiovascular disease. NCEP main page Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report, ...
... (CVD) is a class of diseases that involve the heart or blood vessels. Cardiovascular disease includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, heart arrhythmia, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease in question. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol consumption, among others. High blood pressure results in 13% of CVD deaths, while tobacco results in 9%, diabetes 6%, lack of exercise 6% and obesity 5%. Rheumatic heart disease may follow ...
Over 3,000 peer-reviewed scientific papers have been published related to the Framingham Heart Study. It is generally accepted that the work is outstanding in its scope and duration, and overall is considered very useful. It was rightly assumed from the start of the Framingham Heart Study that cardiac health can be influenced by lifestyle and environmental factors, and by inheritance. The Framingham Heart Study is the source of the term risk factor. Before the Framingham Heart Study, doctors had little sense of heart disease prevention. In the 1950s, it was believed that clogging of arteries and narrowing of arteries (atherosclerosis, arteriosclerosis) were normal parts of aging, and that they occurred universally as people became older. High blood pressure (hypertension) and elevated serum cholesterol (hypercholesterolemia) were also seen as normal consequences of aging in the 1950s, and no treatment was available. These and further risk factors, such as homocysteine, were ...
An ambulatist is a licensed health care provider who specializes in the prevention, management, and care coordination of ambulatory patients with chronic diseases by using lifestyle medicine and drug therapy. Nearly half of all Americans live with at least one chronic condition and ~70% of all American deaths can be attributed directly to chronic diseases. Care coordination is necessary to curb the progression and cost associated with chronic disease in The United States. The ambulatist model of care coordination began in 2008 at Creighton University in Omaha, Nebraska. The Cardiovascular Risk Reduction Prog ram (CVRRP) and Diabetes Risk Reduction Program (DMRRP) are employee wellness benefit programs for Creighton employees with the diagnoses of hypertension, dyslipidemia and/or diabetes. The programs are run by a health care specialty position called the "ambulatist". An ambulatist can be any licensed health care provider who receives training in direct ...
... is a potent monoclonal antibody, developed by XOMA Corporation, with unique allosteric modulating properties and the potential to treat patients with a wide variety of diseases. Gevokizumab binds strongly to interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine, and downmodulates the cellular signaling events that produce inflammation. IL-1 beta has been implicated in cardiovascular conditions, lung cancer, and auto-inflammatory diseases. On August 25, 2017, XOMA Corporation licensed the global commercial rights to gevokizumab to Novartis. Under the license agreement, Novartis will have worldwide rights to gevokizumab, and will be solely responsible for the development and commercialization of antibodies and products containing antibodies arising from gevokizumab. XOMA received an approximately $16 million upfront payment, and Novartis repaid in its entirety the approximately €12 million of debt owed by XOMA to Les Laboratoires Servier. XOMA is eligible to receive up to $438 ...
இதயக் குழலிய நோய் (Cardiovascular disease) அல்லது இதய நோய் (heart disease) என்றவகை நோய்களில் இதயம் அல்லது குருதிக் கலன்களில் (தமனிகள் மற்றும் சிரைகள்) ஏற்படும் நோய்களாகும். இந்தச் சொற்றொடர் மருத்துவ இயலில் (MeSH C14 அல்லது நோய்களின் பன்னாட்டு புள்ளிவிவர வகைப்பாடு மற்றும் தொடர்புடைய நலச் சிக்கல்கள் 10வது திருத்தம் (ICD10) களில் பயன்படுத்தப்பட்டுள்ளதுபோல) இதயக் குழலிய அமைப்பில் ஏற்படும் எந்த நோய்களைக் ...
23 trials of secondary and tertiary prevention, active treatment using various dietary and pharmacologic agents for a mean of ... 53 as the NNT for primary prevention of MI or cardiovascular death, calculated by Rembold and colleagues, is very close to that ... In 6 trials of primary prevention (excluding 1 trial that evaluated clofibrate, which is no longer used), standard ... The Table compares the NNT for cholesterol reduction in secondary (2) and primary (3) prevention trials with primary prevention ...
Background Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal ... Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal cancer (CRC ... both in primary and tertiary prevention) against several cancers, including CRC.. Meta-analyses of randomized clinical trials ... While both drugs have been tested as single agents, their combination has not been tested in cancer prevention trials. ...
Major CVD prevention trials typically involved tens of thousands of participants. These trials were possible because ... Although similar methods have been used successfully in the world of cardiovascular disease (CVD), they have been absent from ... Thus, geographically-diverse participants could be recruited, and diagnoses did not depend on availability of tertiary care ... This method was used to identify relations between mid-life factors (e.g., alcohol, exercise, antioxidant trial agents) and ...
More information is needed regarding the efficacy in reducing the risk factors of cardiovascular disease (CVD), side effects, ... The feasibility of conducting a large-scale Polypill clinical trial in developing countries remains unclear. ... The centers involved in our study were tertiary care hospitals. They do not reflect the level of medical care provided at ... If it is documented in a large clinical trial that a daily intake of the Polypill reduces the risk of recurrent cardiovascular ...
The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.,/p,,p ... Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal cancer (CRC ... 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer ... Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach ...
Major cardiovascular events were reduced, with 5-year absolute benefit of 55 events per 1000. (...) Prevention of stroke by ... randomised trial. HOT Study Group. Despite treatment, there is often a higher incidence of cardiovascular complications in ... placebo-controlled.Community-based ambulatory population in tertiary care centers.4736 persons ... Major cardiovascular events were reduced (relative risk, 0.68). For deaths from all causes, the relative risk was 0.87.In ...
... only primary prevention interventions in generally healthy people and excluded secondary and tertiary prevention trials and ... Multivitamins in the prevention of cardiovascular disease in men: the Physicians Health Study II randomized controlled trial. ... A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers ... Trial of retinol and isotretinoin in skin cancer prevention: a randomized, double-blind, controlled trial. Southwest Skin ...
Elsen, L., et al., "Long chain N-3 polyunsaturated fatty acids in the prevention of allergic and cardiovascular disease," Curr ... conducted in a tertiary-level university hospital: a randomized, controlled trial," Arch Argent Pediatr. August 2012; 110(4): ...
Interventions to Enhance Adherence to Guideline Recommendations in Secondary and Tertiary Prevention of Heart Failure. J Clin ... International Clinical Trial Day and clinical trials in Ethiopia and Africa. Trials, 15: 493. ... Stang A, Stang M (2014) An inter-state comparison of cardiovascular risk factors in Germany: towards an explanation of high ... results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) study. PLoS One, 9: e95994. ...
... and total cardiovascular events and procedures. New-onset diabetes was a tertiary end point. References (1) Gupta AK, Dahlof B ... 2) The DREAM Trial Investigators. Effect of ramipril on the incidence of diabetes 10.1056/NEJMoa065061. N Engl J Med. 2006;355: ... to test the hypothesis that a newer antihypertensive regimen is more effective than an older regimen in the primary prevention ... 3) The STAR Trial Investigators. Differences in glucose tolerance between fixed-dose antihypertensive drug combinations in ...
Title: The Thoracic and cardiovascular surgeon Volume: 51 ISSN: 0171-6425 ISO Abbreviation: Thorac Cardiovasc Surg Publication ... 7843814 - The use of ceftriaxone in the prevention of urinary tract infection in patients undergo.... 20446784 - Encapsulating ... 11239184 - Clinical deterioration following improvement in the ninds rt-pa stroke trial.. 19628484 - Evaluation of stroke ... peritoneal sclerosis: experience of a tertiary referral center.. Publication Detail: Type: Journal Article ...
... design and carry out clinical trials in cardiovascular disease prevention (primary, secondary and tertiary) phase II, III and ... Advanced Cardiovascular Imaging. The mission of our program is to provide an academically and clinically rigorous training ... Potential areas of practice for our graduates include directorship of a preventive cardiovascular medicine, hypertension clinic ... We anticipate that this training program would actively create educational collaborations with all the current cardiovascular ...
The Cochrane Collaborations tool for assessing risk of bias in randomised trials. British Medical Journal, 343, d5928.CrossRef ... 2017). Meditation and cardiovascular risk reduction: a scientific statement from the American Heart Association. Journal of the ... the clinical experience in a tertiary care hospital. Journal of Cardiopulmonary Rehabilitation, 19(4), 226-234.CrossRefGoogle ... 1.Centre for Cardiovascular & Chronic Care to IMPACCT, Faculty of HealthUniversity of Technology SydneySydneyAustralia ...
CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. ... The fetal cardiovascular response to antenatal steroids in severe early-onset intrauterine growth restriction. Am J Obstet ... Recommended management - If fetus is considered viable by size, deliver as soon as possible at tertiary center. Route ... Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial. Lancet. 1991 Jun 15. 337(8755):1427 ...
The protocol of the Prevention of Weight Regain (POWER) trial has been published previously . The POWER study was a ... The control group received the usual care for diabetes regulation and cardiovascular risk management at our tertiary medical ... This hospital is a tertiary referral centre, but individuals with severe comorbidities were excluded from this trial. Some of ... In our trial, only 18% of participants maintained a weight loss of ≥10% in both the intervention and control groups. Clearly, ...
2018 European review for medical and pharmacological sciences Controlled trial quality: uncertain * Tweet this ... randomized comparative study was done at a state-owned tertiary care teaching hospital.After obtaining the Institutional ... Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency ... Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin ...
Choice of Health Options In prevention of Cardiovascular Events) randomised controlled trial ... Setting: Tertiary referral hospital in Sydney Australia.. Patients: 144 ACS survivors who were not accessing standard cardiac ... Choice of Health Options In prevention of Cardiovascular Events) randomised controlled trial ... Choice of Health Options In prevention of Cardiovascular Events) programme on cardiovascular risk factors in acute coronary ...
Long term effects of dietary sodium restriction on cardiovascular disease outcomes: observational follow-up of the trials of ... Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of ... Resistant hypertension in a tertiary care clinic. Arch Intern Med. 1991;151(9):1786-1792. ... Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683-2693. ...
Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial ( ... Tertiary outcomes include the combined outcome of mild cognitive impairment or dementia, a composite measure of the cognitive ... Cardiovascular disease (including New York Heart Association Class III or IV congestive heart failure, clinically significant ... Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun. 2017 Dec ...
Our results suggest that a future definitive trial is feasible. The ICD-specific PtDA shows promise with respect to preliminary ... Eighty-two consented to the trial randomizing patients to usual care (n = 41) or PtDA intervention (n = 41). Feasibility ... The aim of this research was to evaluate the feasibility of conducting a randomized controlled trial delivering an implantable ... Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. ...
... and atherosclerotic cardiovascular disease. Pathologies underlying these conditions are, in part, attributable to the renin- ... HOPE Trial10 showed primary prevention of cardiovascular end points in diabetic patients older than 55 years with one other ... and tertiary prevention for these prevalent and disabling chronic diseases. ... HOPE Trial10 showed primary prevention of cardiovascular end points in diabetic patients older than 55 years with one other ...
This randomised controlled trial with one year follow-up will be conducted at a tertiary referral hospital. Participants ... We present the rationale and design of a randomised controlled trial testing a modular approachfor the secondary prevention of ... The objective of this study is to investigate whether a modular guided self-choice approach to secondary prevention improves ... participate in secondary prevention as offered in cardiac rehabilitation (CR) programs. However, the majority of patients do ...
... plants within regular diet should be an optimal approach targeted to the primary or secondary rather than tertiary prevention ... Most cardiovascular diseases (CVDs), as well as age-related cardiovascular alterations, are accompanied by increases in ... The purpose was to select the most promising candidates for potential use in the human intervention trials described further on ... Optimal platelet function is therefore, an important tool in the prevention of CVD.. Six plant food extracts (dill, sideritis, ...
Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease. ... Randomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis. ... Randomized phase 2 trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for ... Randomized clinical trial of BioFoam® Surgical Matrix to achieve hemostasis after liver resection. ...
... secondary prevention of complications in diabetic subjects free of disease, and tertiary prevention of further complications in ... and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16:434-444, ... Prevention studies include the Da Qing Study (showing 31-46% risk reduction), the Finnish Prevention Study (showing 58% risk ... Levels of prevention can be classified as primary prevention of diabetes itself, ...
Isolated systolic hypMorbidity and mortaIncreased cardiovascular diseaseMortalityAssociated with cardiovascular diseaseMyocardialDiseasesCentreMajor cardiovascularCardiacDiabetesInterventionPlacebo-controlled trialAtherosclerotic cardiovascular diseaseOutcomePreventiveEventsAspirinParticipantsObesityPrimary and secondaryAdverseTreatmentClinical trialRisk factors of cardiovascularHospitalCentersMethodsObservationalDisordersPolypillDisease riskStrokeStudyInterventionsSurgerySpecific cardiovascularInflammationMedicationStatinsInhibitorsAdherenceHospitalizationsRenalLipidMetforminAntioxidant
- The Table compares the NNT for cholesterol reduction in secondary ( 2 ) and primary ( 3 ) prevention trials with primary prevention in isolated systolic hypertension ( 4 ). (acpjc.org)
- If we assume that our secondary prevention patients have risks and benefits similar to those of patients in the 4S trial ( 2 ), an NNT of 11 compares favorably with the NNT for treatment of isolated systolic hypertension. (acpjc.org)
- Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. (tripdatabase.com)
- Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. (tripdatabase.com)
- To evaluate the benefits of treating dyslipidemia to prevent morbidity and mortality from cardiovascular disease. (acpjc.org)
- Coronary heart disease (CHD) is a major cause of morbidity and mortality in Australia and it is recommended that all persons with unstable angina (UA) or myocardial infarction (MI) participate in secondary prevention as offered in cardiac rehabilitation (CR) programs. (biomedcentral.com)
- 2 Therefore, timely delivery of CVD prevention services, which may be implemented virtually, can help modify risk factors associated with increased morbidity and mortality in patients infected with COVID-19. (acc.org)
- Steven H. Woolf of Virginia Commonwealth University opens the session by emphasizing the consequences of an inadequate focus on disease prevention, including greater morbidity and mortality and lower quality of life. (nap.edu)
- The PHANTOM pilot study was a multi-centre, prospective randomized blinded placebo controlled trial designed to examine functionality, morbidity, and mortality outcomes in patients with heart failure and diabetes mellitus who are treated with metformin therapy over a 6 month period. (biomedcentral.com)
- aims to reduce the burden of morbidity and mortality asso- ciated with cardiovascular disease among Latinos. (cdc.gov)
- Very overbearing has been the enormity of cardiovascular disease, with its attendant morbidity and mortality, taking a great toll on the economies of many nations [ 1 ]. (panafrican-med-journal.com)
- In the western world, cardiovascular disease is the most common cause of human morbidity and mortality. (beds.ac.uk)
- We reviewed the evidence supporting the use of anti- T. cruzi pharmacotherapy (etiological treatment) in order to reduce or avoid the morbidity and mortality of Chagas disease applied on different levels of prevention. (hindawi.com)
- Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality world wide. (ispub.com)
- Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal cancer (CRC) incidence and mortality, including inhibition of distant metastases. (springer.com)
- Metformin has also been associated with decreased colon adenoma recurrence in clinical trials and lower CRC incidence and mortality in epidemiological studies in diabetics. (springer.com)
- In 6 trials of primary prevention (excluding 1 trial that evaluated clofibrate, which is no longer used), standard antidyslipidemic therapy reduced the total cholesterol level by 15% and led to an ARR of 1.6% for nonfatal MI, 0.5% for cardiovascular death, and 0.5% for all-cause mortality. (acpjc.org)
- In 23 trials of secondary and tertiary prevention, active treatment using various dietary and pharmacologic agents for a mean of 4.9 years reduced the total cholesterol level by 18% and led to an ARR of 6.4% for nonfatal MI or cardiovascular death (NNT 16, CI 13 to 19) and 2.7% for all-cause mortality (NNT 37, CI 26 to 64). (acpjc.org)
- Since then, they have been shown to reduce morbidity or mortality in congestive heart failure, myocardial infarction, diabetes mellitus, chronic renal insufficiency, and atherosclerotic cardiovascular disease. (aafp.org)
- Cardiovascular disease prevention using fixed dose pharmacotherapy in Iran: updated meta-analyses and mortality estimation. (wikipedia.org)
- Metformin (MET) has also been associated with decreased CRC incidence and mortality in meta-analyses of epidemiological studies in diabetics and has been shown to decrease by 40% colorectal adenoma recurrence in a randomized trial. (clinicaltrials.gov)
- This review summarizes information relating inflammation to cardiovascular disease (CVD) and cancer since these are major world causes of mortality and morbidity. (statpearls.com)
- Latinos may not be as protected from mortality events among Latino families participating in the pilot program associated with cardiovascular disease (CVD) as postulat- at seven sites was evaluated. (cdc.gov)
- Socioeconomic status in relation to cardiovascular disease and causespecific mortality: A comparison of Asian and Australasian populations in a pooled analysis. (edu.au)
- How effective are antioxidant supplements on mortality in primary and secondary prevention randomised clinical trials? (cochraneprimarycare.org)
- The primary objective of this trial is to determine if cardiac resynchronization defibrillator (CRT-D) in high-risk patients with chemotherapy-induced cardiomyopathy will significantly improve the left ventricular ejection fraction (LVEF) by echocardiography within 6 months of initiating CRT without adversely affecting mortality. (mdanderson.org)
- The D-Health Trial: A trial of vitamin D for prevention of mortality and cancer in older Australian adults. (anzctr.org.au)
- A randomised placebo-controlled trial of high-dose vitamin D supplementation for prevention of mortality and cancer in Australian adults aged 60-79. (anzctr.org.au)
- It significantly reduced high-sensitivity C-reactive protein by 22%, which is an important marker of underlying inflammation associated with cardiovascular disease. (pharmaphorum.com)
- Isolated elevated serum LDL and a combination of elevated serum LDL and other abnormal serum lipids have been shown to be associated with cardiovascular disease [ 9 , 10 ]. (panafrican-med-journal.com)
- We hypothesised that traditional and diabetes-specific cardiovascular risk factors were prevalent and strongly associated with cardiovascular disease (CVD) among adults with type 1 diabetes attending Australian diabetes centres. (deepdyve.com)
- Randomized studies were selected if they involved standard antidyslipidemic therapy (diet, pharmaceutical agents, or surgery) and included patients with multiple atherosclerosis risk factors but no known coronary atherosclerosis (primary prevention studies), patients with known atherosclerosis (secondary prevention studies), or patients with a previous myocardial infarction (MI) (tertiary studies). (acpjc.org)
- 5 years of treatment of dyslipidemia in patients with and without known atherosclerosis prevents myocardial infarction or cardiovascular death with a number needed to treat of 16 patients and 53 patients, respectively. (acpjc.org)
- 2 In 2000, Bahit and colleagues 3 reviewed actual versus ideal prescribing of drugs for secondary prevention after myocardial infarction and estimated that 30,600 lives would be saved annually by offering ACE inhibitors. (aafp.org)
- Australian guidelines recommend all persons with unstable angina (UA) or myocardial infarction (MI) participate in secondary prevention [ 2 ] incorporating risk factor management. (biomedcentral.com)
- Participants were myocardial infarction patients (n=430) admitted to two tertiary referral centres in Brisbane, Australia who completed a six month coronary heart disease secondary prevention trial (ProActive Heart). (biomedcentral.com)
- This study has clinical implications as identification of indicators of lower physical and mental HRQoL outcomes for myocardial infarction patients allows for targeted counselling or coronary heart disease secondary prevention efforts. (biomedcentral.com)
- In contrast, the 2018 CANTOS trial on tertiary prevention in patients with a history of myocardial infarction showed that reducing hs-CRP levels by use of canakinumab was effective in reducing (by 25%) a major CVD event but primarily in those patients where treatment lowered hs-CRP to less than 2 mg/ml. (statpearls.com)
- Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. (biomedcentral.com)
- 2 Vascepa reduced total events, first and subsequent events, by 30% compared to placebo, reflecting that for every 1000 patients treated for 5 years with icosapent ethyl versus placebo approximately 159 MACE could be prevented with Vascepa, including prevention of approximately 12 cardiovascular deaths, 42 heart attacks (myocardial infarctions), 14 strokes, 76 coronary revascularizations and 16 episodes of hospitalization for unstable angina. (pharmiweb.com)
- The authors suggest that avoiding hypokalemia is beneficial in several cardiovascular disease states, including acute myocardial infarction, heart failure, and hypertension. (onlinejacc.org)
- Chronic therapies are directed at the prevention of adverse cardiac remodelling following myocardial infarction. (bcs.com)
- In this program, we provide the physician with the clinical knowledge, procedural skills, clinical judgment, professionalism and interpersonal skills required as a multi-modality imaging specialist in cardiovascular diseases. (umn.edu)
- WP3 carried out several in vitro, in vivo experiments, and two intervention studies aimed at the determination of potential effects on the protection of chronic-degenerative diseases, with special respect for cardiovascular risk factors. (europa.eu)
- unlike most of the studies that only investigate the impact of Polypill on indirect surrogate markers of cardiovascular diseases such as blood pressure or lipid profile. (wikipedia.org)
- Cost-effectiveness of a fixed dose combination (polypill) in secondary prevention of cardiovascular diseases in India: Within-trial cost-effectiveness analysis of the UMPIRE trial. (org.in)
- a combination of favorable health habits and conditions that protects against development of cardiovascular diseases. (cdc.gov)
- The review did not assess antioxidant supplements for treatment of specific diseases (tertiary prevention), antioxidant supplements for patients with demonstrated needs for antioxidants, or the effects of antioxidants contained in fruit and vegetables. (cochraneprimarycare.org)
- I am the Principal Investigator of a project regarding Incidence and risk factors of cardiovascular diseases amongst people living with HIV in Sweden: a retrospective cohort study. (ki.se)
- Cardiovascular diseases (CVD) increasingly burden societies with vast financial and health care problems. (beds.ac.uk)
- Therefore, the importance of improving preventive and therapeutic measures against cardiovascular diseases is continually growing. (beds.ac.uk)
- To accomplish such improvements, research must focus particularly on understanding the underlying mechanisms of such diseases, as in the field of epigenetics, and pay more attention to strengthening primary prevention. (beds.ac.uk)
- This review presents the currently available data concerning epigenetic mechanisms and compounds involved in cardiovascular diseases, as well as preventive and therapeutic approaches against them. (beds.ac.uk)
- The goal of etiological treatment against Chagas disease is to eliminate the parasite ( T. cruzi ) from the infected individual, to decrease the probability of developing clinical manifestations of the disease (e.g., cardiovascular or digestive diseases), and to break the chain of disease transmission [ 3 ]. (hindawi.com)
- We want to add atrial fibrillation (AF) after cardiac surgery to the list of cardiovascular diseases where electrolyte imbalance may play an important pathogenetic role. (onlinejacc.org)
- We sought to describe and compare characteristics of patients with Normal hospital Length-of-Stay (NLOS) and PLOS to identify sociodemographic and disease-specific factors associated with PLOS in a tertiary care institution that attends adults with complicated diseases from all over Mexico. (bioportfolio.com)
- This report discusses a study of antimicrobial susceptibility patterns of blood culture isolates between 2001 and 2009 in non-specialty adult patients at an Australian tertiary referral centre, which found that gram negative bloodsteam infections appeared to be re-emerging, particularly in community onset infections and also amongst the younger patients at the study institution. (health.gov.au)
- This descriptive epidemiological study analysed general and age-group specific trends, and antimicrobial susceptibility patterns of blood culture isolates between 2001 and 2009 in non-specialty adult patients at an Australian tertiary referral centre. (health.gov.au)
- The Royal Adelaide Hospital serves a local population within metropolitan Adelaide, and is also a tertiary referral centre for adjacent rural areas. (mja.com.au)
- Professor Kausik Ray, from the Imperial Centre for Cardiovascular Disease Prevention, at Imperial College London's School of Public Health, said: "This latest study shows that bempedoic acid could be another addition to the arsenal of once-daily, oral cholesterol-lowering treatments available to patients. (pharmaphorum.com)
- 2015 - NHMRC Centre of Research Excellence: Early prevention of obesity in children (EPOCH). (edu.au)
- 2012 - Australian Primary Health Care Research Grants, Centre of Research Excellence: Centre Obesity Management and Prevention Research Excellence in Primary Health (COMPaRE-PHC)$2.5 million over 4 years. (edu.au)
- Restricted cubic splines assessed for non- linearity of diabetes duration and likelihood ratio test assessed for interactions between age, diabetes duration, centre type and cardiovascular outcomes of interest. (deepdyve.com)
- To determine in a multi-centre, double-blinded placebo-controlled randomized trial whether testosterone treatment combined with lifestyle intervention (Weight Watchers) relative to lifestyle intervention alone reduces T2DM incidence and improves glucose tolerance at 2 years. (nih.gov)
- Major cardiovascular events were reduced (relative risk, 0.68). (tripdatabase.com)
- Major cardiovascular events were reduced, with 5-year absolute benefit of 55 events per 1000. (tripdatabase.com)
- Dyslipidemia is a major cardiovascular risk and a great healthcare problem in both the developed and the developing countries [ 2 , 3 ]. (panafrican-med-journal.com)
- No therapy is currently approved to treat such residual cardiovascular risk in the population studied in REDUCE-IT and, prior to the successful results of Vascepa demonstrated in the study, no other therapy had demonstrated a 25% risk reduction compared to placebo on top of statin therapy in a major cardiovascular outcomes trial within the primary endpoint of any patient population. (pharmiweb.com)
- A new analysis of data from the landmark Anglo-Scandinavian Cardiac Outcomes Trial - Blood Pressure Lowering Arm (ASCOT-BPLA) published today in Diabetes Care has identified the major predictors of new-onset diabetes (NOD) in patients with hypertension. (thefreelibrary.com)
- The aim of this study was to analyze the results of pulmonary endarterectomy (PEA) performed simultaneously with additional cardiac procedures in a single tertiary-level center. (physiciansweekly.com)
- Cardiac Troponin and its Relationship to Cardiovascular Outcomes in Community Populations - A Systematic Review and Meta-analysis. (edu.au)
- Researchers at Mount Sinai School of Medicine have found in a Phase II trial that a gene therapy developed at Mount Sinai stabilized or improved cardiac function in people with severe heart failure. (innovations-report.com)
- The CUPID (Calcium Up-regulation by Percutaneous administration of gene therapy In cardiac Disease) trial is a randomized, double-blind, placebo-controlled study, which enrolled 39 patients with advanced heart failure to study the safety and efficacy of SERCA2a. (innovations-report.com)
- The article reports that potassium depletion is important in the pathogenesis of cardiovascular disease and sudden cardiac death. (onlinejacc.org)
- To test this hypothesis, we analyzed data from the Study of Prevention of Postoperative Atrial Fibrillation (SPPAF), a randomized, double-blind, placebo-controlled trial at a single tertiary care center of 253 patients undergoing cardiac surgery. (onlinejacc.org)
- The study was designed to test whether each of three active oral drug regimens-amiodarone plus metoprolol, metoprolol alone, and sotalol-is superior to placebo for prevention of AF after cardiac surgery ( 9 ). (onlinejacc.org)
- This might be the reason for the higher incidence of cardiac dysfunction in this trial than was previously reported. (medscape.com)
- The mission of the Cardiology clinical research team is to eliminate cardiac complications arising from cancer treatment and to provide optimal management of pre-existing heart disease to ensure proper delivery of the most effective cancer treatment available through patient care, research, prevention, and education. (mdanderson.org)
- Named after nationally renowned heart surgeon Dr. John Ochsner, the John Ochsner Heart and Vascular Institute (JOHVI) is a comprehensive cardiac and vascular tertiary care center with multiple locations, making it convenient to connect the communities we serve to the excellent quality care they need. (ochsner.org)
- A recent metanalysis of 22 clinical trials suggests that the association between antihypertensive agents and incident diabetes is lowest for ACE inhibitors and angiotensinogen-receptor blockers, followed by calcium channel blockers and placebo, with beta-blockers and diuretics having a diabetogenic effect. (thefreelibrary.com)
- Lifestyle interventions that reduce weight improve a number of cardiovascular disease risk factors in adults with type 2 diabetes [ 1 , 2 ], but studies using hard endpoints have been disappointing. (springer.com)
- Peter Savage (Ellicott City, MD) discussed secular trends in cardiovascular disease (CVD) among patients with diabetes. (diabetesjournals.org)
- The Cardiovascular Health Study showed that rates of glucose, blood pressure, and lipid control, and of aspirin administration for older persons with diabetes, are less likely to be at goal than for those without diabetes (recognizing that goals are stricter for persons with diabetes) ( 2 ). (diabetesjournals.org)
- Steven Haffner (San Antonio, TX) discussed the primary prevention of CVD in patients with type 2 diabetes. (diabetesjournals.org)
- We designed and implemented a pilot study, PHANTOM ( P atients with H eart Failure AN d T ype 2 Diabetes Treated with Placebo O r M etformin), to evaluate the feasibility of a large randomized controlled trial of metformin in patients with heart failure and type 2 diabetes ( ClinicalTrials.gov Identifier: NCT00325910) . (biomedcentral.com)
- Diabetes also is a well-known risk factor for cardiovascular disease. (biomedcentral.com)
- The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) labeled diabetes as a cardiovascular risk equivalent, such that lipid management recommendations are similar for patients with diabetes and patients with CHD [ 15 ]. (biomedcentral.com)
- Despite being known as a cardiovascular risk factor, it is not known whether gout is a cardiovascular risk equivalent [ 16 ] similar to diabetes. (biomedcentral.com)
- Therefore, the objectives of the present study were (1) to assess whether gout is a cardiovascular risk equivalent for incident MI and stroke similar to diabetes, (2) to estimate the increased cardiovascular risk with gout for women and men in various age groups, and (3) to examine if gout is additive to diabetes for cardiovascular risk. (biomedcentral.com)
- REDUCE-IT was a global study of 8,179 patients who, despite stable statin therapy, had elevated triglyceride levels (at least 135 mg/dL) and either documented cardiovascular disease or diabetes with other cardiovascular risk factors. (pharmiweb.com)
- Zoungas, Sophia 2018-06-02 00:00:00 Background: Cardiovascular risk stratification is complex in type 1 diabetes. (deepdyve.com)
- Given the approximate J-shaped association between type 1 diabetes duration and CVD, the impact of cardiovascular risk stratification and management before and after 20 years dura- tion needs to be further assessed longitudinally. (deepdyve.com)
- Diabetes specific cardiovascular risk stratification tools incorporating diabetes duration should be an important consideration in future guideline development. (deepdyve.com)
- Cardiovasc Diabetol (2018) 17:77 Page 2 of 12 We thus examined the burden of cardiovascular risk Background factors and their associations with cardiovascular com- Cardiovascular disease (CVD) is the leading cause of plications among patients with type 1 diabetes attend- death among people with type 1 diabetes [1- (deepdyve.com)
- Traditionally thermore, people with type 1 diabetes experience car- considered and diabetes specific cardiovascular risk fac - diovascular events about 10 years earlier than a matched tors were hypothesised to be prevalent and strongly asso- population without diabetes . (deepdyve.com)
- Applying the framework of economics to resource allocation in diabetes prevention and control is important for at least 3 reasons. (annals.org)
- Second, resources that can be devoted to prevention and control of diabetes are limited because of the "opportunity cost" of doing so. (annals.org)
- We describe how economic analyses can inform and guide policy decisions about allocation of resources in the prevention and care of diabetes. (annals.org)
- Based upon promising results from a pilot study among 424 sedentary older adults who were randomized to a physical activity intervention or a successful aging health education intervention, a Phase 3 multi-center randomized controlled trial is being conducted to compare a moderate-intensity physical activity program to a successful aging health education program in 1,600 sedentary older adults who are followed for an average of 2.7 years. (clinicaltrials.gov)
- Eighty-two consented to the trial randomizing patients to usual care ( n = 41) or PtDA intervention ( n = 41). (biomedcentral.com)
- For primary prevention patients in particular, the decision to receive this life-prolonging intervention may not be straightforward. (biomedcentral.com)
- an intervention approach in which individual cardiovascular disease (CVD) events (e.g., heart attack, heart failure, stroke) are treated as they occur. (cdc.gov)
- Several health-related parameters were assessed before and after a 16-weeks intervention: physical fitness (primary outcome), body composition (secondary), and lipid-metabolic profile, ventilatory parameters, blood pressure, and cognitive and academic performance (tertiary outcomes). (clinicaltrials.gov)
- In this regard, etiological treatment has shown to be beneficial as an intervention for secondary prevention to successfully cure the infection or to delay, reduce, or prevent the progression to disease, and as primary disease prevention by breaking the chain of transmission. (hindawi.com)
- bed rest care in the nursing interventions classification , a nursing intervention defined as promotion of comfort and safety and prevention of complications for a patient unable to get out of bed. (thefreedictionary.com)
- Multiple studies demonstrate the benefit of a vegan diet on cardiovascular risk factors when compared to no intervention or usual dietary patterns. (readbyqxmd.com)
- 2 , 3 Since JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin), 4 the relevance of inflammation as a new modifiable cardiovascular risk factor has been increasingly observed. (ahajournals.org)
- The PIRRIST project will develop and evaluate a PPI intervention aimed at enhancing recruitment and retention in surgical trials. (jenner.ac.uk)
- A pilot double-blind randomised placebo-controlled trial of the effects of xed-dose combination therapy ('polypill') on cardiovascular risk factors. (wikipedia.org)
- The pilot study was a randomized double blinded placebo controlled trial. (biomedcentral.com)
- In brief, REDUCE-IT was a phase 3b randomized, double-blind, placebo-controlled trial comparing icosapent ethyl (2 g twice daily with food [total daily dose, 4 g]) with a placebo that contains mineral oil to mimic the color and consistency of icosapent ethyl. (doccheck.com)
- In a double-blind, placebo-controlled trial, Dr. Guglin and colleagues studied HER2-positive breast cancer treated with trastuzumab for 12 months and followed for two years. (medscape.com)
- Esperion's international Study 1 tested the drug versus placebo in 2,230 high-risk patients with atherosclerotic cardiovascular disease (ASCVD) that was inadequately controlled with lipid-modifying therapies, including maximum doses of statins. (pharmaphorum.com)
- Tertiary outcomes include the combined outcome of mild cognitive impairment or dementia, a composite measure of the cognitive assessment battery, physical performance within pre-specified subgroups defined on the basis of race, gender and baseline physical performance, sleep-wake disturbances, dyspnea, ventilatory capacity, cardiopulmonary events, and cardiovascular events. (clinicaltrials.gov)
- The trial did not reach statistical significance for the primary outcome and there were blood pressure differences between the two arms that could account for all of the differences noted in the secondary and post-hoc tertiary end points. (prescriber.org.uk)
- Despite the improvement of cardiovascular outcome and survival of heart failure patients through strategies of classical pharmacological treatment (e.g., the use of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors), such therapies are ultimately unable to prevent further progression of the disease itself [ 10 ]. (beds.ac.uk)
- Aspirin and metformin, two common, safe and inexpensive drugs with a broad spectrum of preventive effects on several target systems, have recently shown a preventive potential (both in primary and tertiary prevention) against several cancers, including CRC. (springer.com)
- In this concluding session of the May workshop, the speakers reframed the discussion by exploring how changing demographic trends in the population's health status and underinvestment in population health contribute to missed prevention opportunities, and focusing not simply on the potential costs of missed prevention opportunities but on the added value of increasing the delivery of preventive efforts to patients. (nap.edu)
- Thomas J. Flottemesch of HealthPartners Research Foundation suggests that preventive services at the primary and secondary levels yields mixed results in terms of net medical savings to the healthcare system, highlighting the importance of expanding the conversation on prevention beyond costs alone to include value and benefits not captured by pure dollars. (nap.edu)
- Michael P. Pignone of the University of North Carolina-Chapel Hill focuses on tertiary preventive care, explaining that individuals with one or more chronic conditions account for approximately $1.5 trillion in healthcare spending per year. (nap.edu)
- Observational study of 259 consecutive patients admitted to a tertiary hospital stroke unit from 24 January 2006 to 10 January 2007, with retrospective assessment of prestroke risk factors and therapies to determine stroke preventability, based on relative risk reductions from published meta-analyses of preventive therapies. (mja.com.au)
- To determine the effect of a new CHOICE (Choice of Health Options In prevention of Cardiovascular Events) programme on cardiovascular risk factors in acute coronary syndrome (ACS) survivors. (bmj.com)
- ASCOT-BPLA was a major multinational trial involving over 19,000 hypertensive patients that compared the effectiveness of two different treatment strategies at reducing cardiovascular events. (thefreelibrary.com)
- Sodium restriction was also recently shown to lower cardiovascular events. (aafp.org)
- NICE have published the Final Appraisal Determination for Statins in Prevention of Cardiovascular Events. (prescriber.org.uk)
- For CVD, primary prevention refers to detection and control of risk factors, whereas secondary prevention includes long-term case management for survivors of CVD events. (cdc.gov)
- Estimated GFR and incident cardiovascular disease events in American Indians: The Strong Heart Study. (howard.edu)
- Results - A total of 8.179 patients were enrolled (70.7% for secondary prevention of cardiovascular events) and were followed for a median of 4.9 years. (doccheck.com)
- BEDMINSTER, N.J. and DUBLIN, March 18, 2019 /PRNewswire/ -- Amarin Corporation plc (NASDAQ: AMRN), presented new data from its landmark cardiovascular outcomes study of its prescription therapy, Vascepa® (icosapent ethyl), the REDUCE-IT™ study, showing that Vascepa provided a statistically significant 30% risk reduction in total (first and subsequent) cardiovascular events compared to placebo in the statin-treated patient population studied in REDUCE-IT. (pharmiweb.com)
- These data presented today as a late-breaker presentation at the American College of Cardiology's (ACC) 68th Annual Scientific Session in New Orleans, LA, and published simultaneously in the Journal of the American College of Cardiology , extend the scope of consistent effects of Vascepa beyond a patient's first cardiovascular event to all subsequent cardiovascular events, including cardiovascular death. (pharmiweb.com)
- In the newly reported data, investigators led by the study's principal investigator, Deepak L. Bhatt, MD, MPH, Professor of Medicine at Harvard Medical School, Executive Director of Interventional Cardiovascular Programs in the Heart and Vascular Center at Brigham and Women's Hospital, and the Principal Investigator and Steering Committee Chair for REDUCE-IT, evaluated patients' total cardiovascular events during the median study follow up of 4.9 years in REDUCE-IT. (pharmiweb.com)
- Recurrent cardiovascular events are common in people who have already had a heart attack. (pharmiweb.com)
- There was also a 28% reduction of total events in the key secondary endpoint of 3-point MACE in the intent-to-treat population consisting of a composite of cardiovascular death, nonfatal heart attack and nonfatal stroke. (pharmiweb.com)
- Many patients with well-managed LDL-cholesterol remain at high risk for cardiovascular events. (pharmiweb.com)
- As a consequence of better primary and secondary prevention, there is a decrease in cardiovascular events in type 1 and type 2 diabetic patients, as well as an increased life expectancy. (beds.ac.uk)
- Haematocrit, lipids and prostate-specific antigen (PSA) are assessed 6-monthly and information relating to haematological, urological and cardiovascular adverse events from each clinic visit. (nih.gov)
- Chronic psychosocial stress and serum uric acid (SUA) level have been implicated in the etiology and cardiovascular events risk factors in hypertension. (who.int)
- The increasing use of aspirin in the prevention of cardiovascular events and the availability of select over-the-counter NSAIDs represent additional challenges to clinicians in their efforts to make the most appropriate therapeutic decisions while minimizing the potential gastrointestinal risks associated with the use of these agents. (biomedcentral.com)
- This is a randomized, placebo-controlled, double-blind, 2 × 2 biomarker trial of aspirin and metformin to test the activity of either agent alone and the potential synergism of their combination on a set of surrogate biomarkers of colorectal carcinogenesis. (springer.com)
- After surgery, 160 patients with stage I-III CRC are randomly assigned in a four-arm trial to either aspirin (100 mg day), metformin (850 mg bis in die) , their combination, or placebo for one year. (springer.com)
- A favorable biomarker modulation by aspirin and metformin may provide important clues for a subsequent phase III adjuvant trial aimed at preventing second primary cancer, delaying recurrence and improving prognosis in patients with CRC. (springer.com)
- The trial compared a Polypill (75 mg aspirin, 20 mg simvastatin, 10 mg lisinopril and 12.5 mg hydrochlorothiazide) to Standard Practice. (biomedcentral.com)
- Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. (tripdatabase.com)
- A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose Aspirin and Metformin in Stage I-III Colorectal Cancer Patients. (clinicaltrials.gov)
- The landmark trial, their cardiovascular event rate was beats per minute or em h , low dose aspirin was bene cial to deep, are the next generation of cyclic adenosine monophosphate cyclic guanosine monophosphate cgmp, release of substance abuse, and potential urgent treatmentempiric treatment can be troublesome with inhaled nitric oxide ino. (roanokechowan.edu)
- Major CVD prevention trials typically involved tens of thousands of participants. (alz.org)
- Thus, geographically-diverse participants could be recruited, and diagnoses did not depend on availability of tertiary care specialists. (alz.org)
- It should be noted that most participants in the CANTOS trial were already on statin therapy. (statpearls.com)
- Abstract: Poor recruitment and retention of participants is one of the major causes of clinical trial extension (both time and cost) and failure. (jenner.ac.uk)
- With evidence that nearly 40 percent of all deaths in the United States are due to behavioral causes, attention to prevention has encompassed obesity and tobacco smoking prevention in addition to vaccinations and cancer screening (Mokdad et al. (nap.edu)
- While he emphasizes the importance of community- or population-based prevention services, he uses obesity as a case study to demonstrate how lost opportunities in prevention result in measurable health costs and excess resource consumption. (nap.edu)
- 7) The National Task Force on the Prevention and Treatment of Obesity reported that 90% of patients treated with VLCDs in randomised trials lose 10 kg or more within six months. (thefreelibrary.com)
- Since completing her PhD in 2005, her research has focused on obesity prevention and management with a focus on the role of nurses and the primary health care setting. (edu.au)
- 2016- 2017: Management and prevention of child obesity in primary care: developing resources for GPs and Practice Nurses. (edu.au)
- I have been consulting to the Premier's priority task force developing strategies to improve prevention and management of child obesity. (edu.au)
- Children, Obesity and Exercise: Prevention, Treatment and Management of Childhood and Adolescent Obesity - International Studies in Physical Education and Youth Sport Series , (pp. 25-36). (edu.au)
- We recommend using modern definitions of severe obesity in children with the Centers for Disease Control and Prevention age- and sex-matched growth charts defining class II obesity as 120% of the 95th percentile and class III obesity as 140% of the 95th percentile. (asmbs.org)
- While prevention remains the mainstay of obesity policy, in children who develop severe obesity, it has become clear that MBS is a safe and effective treatment for these children and should be considered more readily by primary care physicians. (asmbs.org)
- In the setting of the COVID-19 pandemic, a tremendous opportunity arises for implementation and development of primary and secondary cardiovascular prevention via telehealth platforms. (acc.org)
- POLYIRAN in Primary and Secondary Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranian. (wikipedia.org)
- To identify and quantify current deficiencies in primary and secondary stroke prevention, as well as potential gains from optimal employment of thrombolysis. (mja.com.au)
- We designed The Royal Adelaide stroke disability Prevention Study (TRAPS) to identify and quantify current deficient areas in primary and secondary prevention, as well as to estimate the potential benefits of optimal thrombolysis. (mja.com.au)
- For the investigators, given the evidence from ASCOT-BPLA and previous trials, it seems that the beneficial effect of the amlodipine/perindopril regimen is largely a composition of the protective effect of Coversyl, amlodipine playing a neutral role, whereas atenolol and thiazide have adverse effects. (thefreelibrary.com)
- 1 The adverse impact on cardiovascular care delivery and outcomes will likely be long-lasting if our health systems do not adapt quickly and efficiently. (acc.org)
- More efficacy, tolerability, and adverse event data are being generated as the results of phase 4 cardiovascular safety trials for DPP-4 inhibitors, SGLT2 inhibitors, and GLP-1 agonists continue to be reported, and further comparative efficacy trials of candidate second-line therapies are in progress. (medicographia.com)
- Cardiovascular medications have been cited as one of the most common classes of drugs associated with medication errors and adverse drug reactions, which need to be monitored from time to time. (ispub.com)
- The adverse drug event (ADE) prevention study group reported that odds ratio (OR) of severe ADEs with cardiovascular medication was 2.4 times that of other medications. (ispub.com)
- Without similar means for conducting Alzheimer's research on a large scale, it may be impossible to achieve comparable gains in prevention and treatment of MCI and dementia. (alz.org)
- Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs) will relapse if treatment is withdrawn, but various trials have recently demonstrated that a significant proport. (biomedcentral.com)
- principal results of the Hypertension Optimal Treatment (HOT) randomised trial. (tripdatabase.com)
- Despite treatment, there is often a higher incidence of cardiovascular complications in patients with hypertension than in normotensive individuals. (tripdatabase.com)
- Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: a randomized, controlled trial," Arch Argent Pediatr. (doctorshealthpress.com)
- The newer treatment strategy (amlodipine and perindopril) offered such significant advantages over the older treatment strategy (atenolol and bendroflumethiazide) that the trial was stopped early by the Data Safety Monitoring Board in December 2004. (thefreelibrary.com)
- The second arm (3500 subjects) receive recommendation about healthy lifestyle in face to face interviews and pamphlets, undergo blood pressure measurements in 6 months regular intervals and are referred to secondary or tertiary medical centers for treatment upon necessity(minimal care arm). (wikipedia.org)
- Preeclampsia (PE) is a serious maternal inflammatory disease with endothelial cell dysfunction, and there is a lack of effective treatment and prevention. (physiciansweekly.com)
- There is no mention of cholesterol targets in the document but it seems likely that the Primary Prevention risk threshold for treatment will be rolled back to 15% CHD risk (or 20% CVD) as originally detailed in the National Service Framework for CHD. (prescriber.org.uk)
- Esperion is also waiting for results from the CLEAR OUTCOMES trial, which is testing longer-term safety and whether the treatment reduced cardiovascular disease risk in addition to lowering cholesterol. (pharmaphorum.com)
- To ensure the most effective prevention and treatment possible, further studies are required to understand the complex relationship between epigenetic regulation and the development of CVD. (beds.ac.uk)
- Expenses for the treatment of cardiovascular disease to the European health care system are presumed to be as high as 200 billion Euros each year [ 1 ]. (beds.ac.uk)
- Few treatment options have shown such improved clinical outcomes in this patient population in the last decade," said Roger J. Hajjar, MD, Research Director of Mount Sinai's Wiener Family Cardiovascular Research Laboratories, and the Arthur and Janet C. Ross Professor of Medicine, and Gene and Cell Medicine, Mount Sinai School of Medicine. (innovations-report.com)
- They focus on costly secondary and tertiary care and they emphasise treatment rather than prevention. (co.rw)
- Our most important finding is that patients on trastuzumab respond differently to pharmacologic prevention of cardiotoxicity based on prior treatment with anthracyclines. (medscape.com)
- Dr. Ana Barac of the Medstar Washington Hospital Center in Washington, DC, coauthor of a related editorial, commented by email, "As a result of this and several similar recent studies, I believe that more oncologists will consider using beta-blockers and angiotensin-cardioverting enzyme inhibitors at the initiation of cancer treatment with high cardiovascular risk. (medscape.com)
- Prevention and treatment of cardiovascular disease in adolescents and adults. (truthabouttm.org)
- Clinical and Pre-clinical Applications of the Transcendental Meditation Program® in the Prevention and Treatment of Essential Hypertension and Cardiovascular Disease in Youth and Adults: A Research Review. (truthabouttm.org)
- Through ongoing research initiatives, physician training programs and clinical trials, JOHVI continues to set the standard for diagnosis and treatment of heart disease. (ochsner.org)
- The feasibility of conducting a large-scale Polypill clinical trial in developing countries remains unclear. (biomedcentral.com)
- We conducted an open-label, parallel-group, randomized clinical trial involving three sites in Sri Lanka that enrolled a total of 216 patients without established CVD. (biomedcentral.com)
- To address these questions and other relevant issues such as study feasibility, we conducted a clinical trial sponsored by the World Health Organization (WHO) in Sri Lanka. (biomedcentral.com)
- Fekadu A, Teferra S, Hailu A, Gebre-Mariam T, Addissie A , Deressa W, Yimer G, Reja A (2014) International Clinical Trial Day and clinical trials in Ethiopia and Africa. (uni-halle.de)
- Association of patient preferences on medication discussion in hypertension: Results from a randomized clinical trial. (physiciansweekly.com)
- Gene, exercise and memory study (GEMS): A randomized controlled clinical trial to evaluate the effects of standardized aerobic exercise on neurocognition and neurodegeneration in african americans with mild Alzheimer's disease. (howard.edu)
- Efficacy and Safety of Sanfu Herbal Patch at Acupuncture points for Persistent Allergic Rhinitis (SPAR): a randomized controlled clinical trial. (ki.se)
- Design Randomised, blinded, placebo controlled clinical trial. (bmj.com)
- Additionally, potassium replacement may reduce the risk of postoperative AF and should be tested prospectively in a controlled clinical trial. (onlinejacc.org)
- Tertiary referral hospital in Sydney Australia. (bmj.com)
- of vecuronium.A prospective, randomized comparative study was done at a state-owned tertiary care teaching hospital.After obtaining the Institutional Ethical Committee approval and written informed consent, sixty patients of either gender aged 18-60 years, the American Society of Anesthesiologists physical status Class I/II, weighing 40-70 kg, were randomly divided into two groups of thirty each. (tripdatabase.com)
- This randomised controlled trial with one year follow-up will be conducted at a tertiary referral hospital. (biomedcentral.com)
- A prospective trial was conducted in a paper-based unit (PB-U) versus a computerized unit (C-U) in a 22-bed ICU of a tertiary university hospital. (nih.gov)
- The Prairie Heart Institute (PHI) combines the 55-member Prairie Cardiovascular Consultants with St. John's Hospital and is based in Springfield, Illinois' capital city. (eplabdigest.com)
- In a 6-month trial in the Hunter Valley, NSW, ambulance officers were encouraged to use a pre-hospital stroke assessment tool and divert all potentially thrombolysis-eligible patients to the regional tertiary referral hospital, while notifying the hospital acute stroke team via a text message (Quain et al, "Improving access to acute stroke therapies: a controlled trial of organised pre-hospital and emergency care" ). (mja.com.au)
- Setting Tertiary public hospital in Mexico City. (bmj.com)
- The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. (innovations-report.com)
- The hospital care secondary prevention. (roanokechowan.edu)
- Risk factors associated with prolonged hospital length-of-stay: 18-year retrospective study of hospitalizations in a tertiary healthcare center in Mexico. (bioportfolio.com)
- Study was done at Government Tertiary Care Hospitals of Peshawar namely Khyber Teaching Hospital (KTH), Lady Reading Hospital (LRH) and Hayatabad Medical Complex (HMC).The hospital based case-control study included 50 cases (stroke patients) and 100 controls (non-stroke patients). (beds.ac.uk)
- St. Boniface Hospital is a tertiary health care facility, employing nearly 700 doctors and around 1,500 nurses. (wikipedia.org)
- The hospital also participates in clinical trials of research discoveries. (wikipedia.org)
- The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- According to the U.S. Centers for Disease Control and Prevention, about 5.8 million Americans suffer from heart failure, and 670,000 new cases are diagnosed each year. (innovations-report.com)
- Both in tertiary institutions and in community centers, the worlds of cardiology and oncology tend to be separate with minimal overlap. (medscape.com)
- From the Centers for Disease Control and Prevention, Atlanta, Georgia. (annals.org)
- Although similar methods have been used successfully in the world of cardiovascular disease (CVD), they have been absent from Alzheimer research. (alz.org)
- A mixed methods evaluation of yoga as a fall prevention strategy for older people in India. (org.in)
- current national strategies in primary prevention of CVD that focus on absolute cardiovascular risk stratification Methods from around 40 years of age regardless of comorbidities Subjects [1, 8- (deepdyve.com)
- Professor Kinsman has run several large multi-site research projects, including a cluster randomised controlled trial across six rural hospitals to improve heart management, a mixed methods study across 14 primary care practices to investigate the quality of heart disease prevention and management, and is currently investigating the impact of 'lean' on the Saskatchewan health system. (edu.au)
- The course focuses on the application of theories of behavioral change for solving health and public health problems, including stages of change, relapse prevention, social advertising and social marketing methods for use in primary care and community settings. (northwestern.edu)
- Two investigators independently selected and reviewed fair- and good-quality trials for benefit and fair- and good-quality trials and observational studies for harms. (annals.org)
- Oxidative stress may play a role in the pathogenesis of cancer and cardiovascular disease, the leading causes of death in middle- and high-income countries.¹ Several observational studies have shown a significant positive association between higher intake of fruits and vegetables and reduced risk of chronic disease.² Many people take antioxidant supplements in the belief that they will improve their health.³ 1. (cochraneprimarycare.org)
- It is based on several strong evidences supported by basic research, clinical trials, observational studies, and expert opinions. (hindawi.com)
- BMC Cardiovascular Disorders , 14, 1-10. (edu.au)
- The hospital's primary research mandate is in cardiovascular studies, imaging (especially MRI), neurodegenerative disorders, and nutraceuticals. (wikipedia.org)
- Its primary research mandate addresses three main areas: cardiovascular sciences, magnetic resonance imaging (MRI) and spectroscopy, and degenerative disorders associated with aging. (wikipedia.org)
- These findings suggest a high rate of patient acceptability, a finding that is bolstered by the majority of patients completing the trial (90%) indicating that they would take the Polypill "for life" if proven to be effective in reducing CVD risk. (biomedcentral.com)
- Approximately 86% of the physicians surveyed agreed with and supported use of the Polypill for primary prevention and 93% for secondary prevention of CVD. (biomedcentral.com)
- We successfully completed a Polypill feasibility trial in Sri Lanka. (biomedcentral.com)
- The Polypill was however simpler and achieved comparable risk factor reductions, highlighting its potential usefulness in the prevention of CVD. (biomedcentral.com)
- Other limitations of previous studies were that adjustment for key cardiovascular risk factors was not performed in studies of MI [ 5 , 7 ] and stroke [ 7 ], which raises a serious concern for significant confounding. (biomedcentral.com)
- This case controlled study was conducted in Tertiary care hospitals of Peshawar, KPK Pakistan about common risk factors of stroke and the impact of these risk factors. (beds.ac.uk)
- Prevention of these risk factors can lead to decrease in the incidence of stroke. (beds.ac.uk)
- similarly, 16 as the NNT for secondary prevention is comparable to the NNT in the Scandinavian Simvastatin Survival Study (4S) trial ( 2 ). (acpjc.org)
- with vecuronium when given as a bolus, as is given routinely.This study was undertaken to evaluate and compare the neuromuscular effect of vecuronium during anesthesia with oxygen, nitrous oxide and isoflurane versus oxygen, air and isoflurane.The study was a prospective, randomized controlled trial on 70 patients allocated into two groups as follows: Group N (nitrous oxide group) and Group A (medical air group). (tripdatabase.com)
- The LIFE Study was a Phase 3, multicenter randomized controlled trial (RCT) designed to compare a moderate-intensity physical activity program to a successful aging health education program in 1,600 sedentary older persons who are followed for an average of 2.7 years. (clinicaltrials.gov)
- The PolyIran study is a pragmatic open-labeled randomized trial being conducted within Golestan cohort study (GCS) on 31000 subjects in 305 villages of Golestan Province, northeastern Iran. (wikipedia.org)
- Therefore, we attempted to conduct a pilot study to evaluate the feasibility of undertaking a large randomized controlled trial with clinical endpoints. (biomedcentral.com)
- This paper describes our experiences in the implementation of the PHANTOM Pilot study and its implications for other clinical trials. (biomedcentral.com)
- Despite this the study is being heralded as a landmark trial. (prescriber.org.uk)
- Detailed analyses by age and sex (risk varies by these factors) were performed in one study [ 7 ], which did not control for cardiovascular risk factors such as hypertension and hyperlipidemia. (biomedcentral.com)
- Benefits of Vascepa with respect to total cardiovascular event reduction were shown to continue over time as displayed below in the cumulative event curves of study results. (pharmiweb.com)
- It is an ongoing study where the antibiotics prescribed to the patients admitted in two Indian tertiary care hospitals is being followed since 2007. (ki.se)
- We are funded by the Cancer Prevention Research Institute of Texas (CPRIT) to carry out a clinical study to determine whether genetic markers can be used to predict patients' predisposition to develop doxorubicin-induced cardiotoxicity. (mdanderson.org)
- This study was accomplished from 24th April 2012 to October 2012 in tertiary care hospitals of Peshawar. (beds.ac.uk)
- Heart disease secondary prevention is best achieved through implementation of sustainable pharmacological and non-pharmacological interventions, including meditation. (springer.com)
- Medical services in CVD prevention are particularly well suited for transitioning to telehealth platforms as interventions are centered largely on counseling and are most effective with regular check-ins (in-person or virtual) to reinforce good prevention practices ( Figure 1 ). (acc.org)
- Thus, AF after cardiovascular surgery should be added to a group of cardiovascular disease that may be adversely influenced by low serum potassium concentrations. (onlinejacc.org)
- The findings reported a more lateral on the principles of double effect or spontaneous abortion sab resulting in esophageal migration, gastric outlet obstruction with a cardiovascular complication and require surgery, radiation, and chemotherapy. (dvas.org)
- The registration of different classes of MPE was done according to the National Coordinating Council for Medication Error Reporting and Prevention guidelines. (nih.gov)
- The most frequent drug classes involved were cardiovascular medication and antibiotics in both groups. (nih.gov)
- Mg/d every weeks to months oldtwo examinations over hours for all children will evidence immediate psychological dysfunction and cardiovascular collapse have been identified in stool or virus dna of a stiff teflon catheter is par-ticularly useful for confirming seizure-freedom in children and may be more related to medication use. (raseproject.org)
- Similar benefits on atherosclerosis progression and regression were observed in 9 secondary and tertiary trials evaluating 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. (acpjc.org)
- The benefits of perindopril on NOD have not always been seen with all other RAAS inhibitors: - the recent analyses of the DREAM trial did not show a significantly protective effect of ramipril against NOD(2). (thefreelibrary.com)
- Although angiotensin-converting enzyme (ACE) inhibitors have documented clinical benefits in a variety of clinical situations, the disparity between the evidence from clinical trials and bedside medicine is well documented. (aafp.org)
- Other considerations in selecting a second-line agent are patient preference, cost (the requirement for phase 4 cardiovascular safety trials can add significantly to this in the case of new therapies), and adherence (which is likely to be better with once daily or once weekly rather than multiple times each day). (medicographia.com)
- SMS and voice messaging are used for patient education, reducing risk factors for cardiovascular disease and supporting adherence to therapy. (co.rw)
- 2004), has resulted in targeted prevention of additional complications and hospitalizations. (nap.edu)
- Patients receiving a high dose of the therapy, called SERCA2a, experienced substantial clinical benefit and significantly reduced cardiovascular hospitalizations, addressing a critical unmet need in this population. (innovations-report.com)
- They also saw a dramatic reduction in cardiovascular hospitalizations, averaging 0.4 days versus 4.5 days in the placebo group. (innovations-report.com)
- Tertiary objectives were to assess the effect of bempedoic acid on other lipid parameters and risk markers, including hsCRP. (pharmaphorum.com)
- 10 However, tocilizumab worsens atherogenic lipid profile, increasing total cholesterol (TC), low‐density lipoprotein (LDL), and triglycerides, a finding with uncertain cardiovascular outcomes. (ahajournals.org)
- Despite uncertainty in the scientific literature, there does not appear to be clinical uncertainty with regards to the safety or effectiveness of metformin in HF making a definitive randomized trial virtually impossible. (biomedcentral.com)
- Given the robust debate in the literature about the role of metformin in heart failure, this appeared to be a question that needed to be resolved with a randomized controlled trial[ 26 ]. (biomedcentral.com)
- Indeed, the recent positive cardiovascular outcomes in the first SGLT2 inhibitor phase 4 trial to have been completed may have an important effect on the choice of a suitable partner drug for metformin. (medicographia.com)