Nitric Oxide Donors: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.S-Nitroso-N-Acetylpenicillamine: A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.Nitroprusside: A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.Nitroso CompoundsS-Nitrosoglutathione: A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.OxadiazolesNG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.Nitric Oxide Synthase Type I: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Guanylate Cyclase: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.HydrazinesTissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Arginine: An essential amino acid that is physiologically active in the L-form.Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.Triazenes: Compounds with three contiguous nitrogen atoms in linear format, H2N-N=NH, and hydrocarbyl derivatives.Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.Sydnones: OXADIAZOLES bearing an oxygen at the 5-position. They are mesoionic, with delocalized positive and negative charges.Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Spermine: A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.QuinoxalinesS-Nitrosothiols: A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.Cyclic GMP-Dependent Protein Kinases: A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Blood DonorsRuthenium Compounds: Inorganic compounds that contain ruthenium as an integral part of the molecule.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)Placental Function Tests: Methods used for the assessment of placental function.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Pentaerythritol Tetranitrate: A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)Nicorandil: A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.Azo CompoundsFree Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Nitrosation: Conversion into nitroso compounds. An example is the reaction of nitrites with amino compounds to form carcinogenic N-nitrosamines.Hydroxocobalamin: Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.IndazolesAcetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Pyrogallol: A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.Cyclic Nucleotide Phosphodiesterases, Type 5: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.Amino Acid Oxidoreductases: A class of enzymes that catalyze oxidation-reduction reactions of amino acids.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.PropaneGlutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.PurinonesRabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Placental Circulation: The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.Aorta: The main trunk of the systemic arteries.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Mesenteric Arteries: Arteries which arise from the abdominal aorta and distribute to most of the intestines.Superoxides: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Arteries: The vessels carrying blood away from the heart.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Glyburide: An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Bradykinin: A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.Phosphodiesterase Inhibitors: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Superoxide Dismutase: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.8-Bromo Cyclic Adenosine Monophosphate: A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Forearm: Part of the arm in humans and primates extending from the ELBOW to the WRIST.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Oxidants: Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION).Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Carbazoles: Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Sulfhydryl Compounds: Compounds containing the -SH radical.Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Coronary Vessels: The veins and arteries of the HEART.NADPH Dehydrogenase: A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1.Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Lipid Peroxidation: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Enzyme Induction: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Peroxynitrous Acid: A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.Kinetics: The rate dynamics in chemical or physical systems.Mice, Inbred C57BLMacrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Exhalation: The act of BREATHING out.Guanidines: A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.PiperazinesBreath Tests: Any tests done on exhaled air.Electric Stimulation: Use of electric potential or currents to elicit biological responses.
It is a derivative of naproxen with a nitroxybutyl ester to allow it to also act as a nitric oxide (NO) donor. This second ... Naproxcinoid is metabolized to naproxen and a nitric oxide donating moiety. NO has various cardiovascular effects, including ... 2005). "NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor". Inflammopharmacology. 12 (5-6): 521-34. ... Cirino, G; Distrutti, E; Wallace, JL (2006). "Nitric oxide and inflammation". Inflammation & allergy drug targets. 5 (2): 115-9 ...
Contraindications include: Concomitant use of nitric oxide donors, organic nitrites and nitrates, such as: nitroglycerin ... In 1992, Pfizer filed a patent covering the substance sildenafil and its use to treat cardiovascular diseases. This would be ... Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels ... won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in ...
... nitric oxide donors MeSH D27.505.954.411.645 --- potassium channel blockers MeSH D27.505.954.411.700 --- sclerosing solutions ... cardiovascular agents MeSH D27.505.954.411.097 --- anti-arrhythmia agents MeSH D27.505.954.411.162 --- antihypertensive agents ... nitric oxide donors MeSH D27.505.696.138 --- antispermatogenic agents MeSH D27.505.696.138.379 --- sperm immobilizing agents ...
Hou, Y.C.; Janczuk, A.; Wang, P.G. (1999). "Current trends in the development of nitric oxide donors". Curr. Pharm. Des. 5 (6 ... Research into its function led to the 1998 Nobel Prize for discovering the role of nitric oxide as a cardiovascular signalling ... The inducible isoform of nitric oxide synthase is expressed and produces cytotoxic levels of nitric oxide. Nitric oxide also ... Nitric oxide was named "Molecule of the Year" in 1992 by the journal Science, a Nitric Oxide Society was founded, and a ...
Concomitant use of nitric oxide donors, organic nitrites and nitrates,[20] such as: *nitroglycerin ... Use of Sildenafil (Viagra) in Patients with Cardiovascular Disease". Journal of the American College of Cardiology. 34 (6): 273 ... Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels ... Common side effects include headaches, heartburn, and flushed skin.[3] Caution is advised in those with cardiovascular disease. ...
Nitric oxide (NO) inhibits the NADPH enzyme, blocking the source of oxidative stress in the vasculature. NO donor drugs (also ... Griendling, K. K., Sorescu, D., Ushio-Fukai, M., & Harrison, D. G. (0). NAD(P)H Oxidase Role in Cardiovascular Biology and ... In most studies, NADH is believed to be the preferred electron donor, although reports have shown that NAPDH is equally used as ... Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications. Pharmacol Ther 89: 187-206. ...
NO is generated intracellularly by the nitric oxide synthase (NOS) family of enzymes: nNOS, eNOS and iNOS while the in vivo ... NO coexists in cells with SNOs that serve as endogenous NO carriers and donors. SNOs spontaneously release NO at different ... Studies suggest that NO metabolism has a significant role in human cardiovascular and respiratory diseases as well as in immune ... S-Nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol (SNO) that plays a critical role in nitric oxide (NO) signaling and ...
ISBN 978-1-4020-5344-3. Hou, YC; Janczuk, A; Wang, PG (1999). "Current trends in the development of nitric oxide donors". ... Hayward, CS; Kelly, RP; MacDonald, PS (1999). "Inhaled nitric oxide in cardiology practice". Cardiovascular research. 43 (3): ... is the reduced form of nitric oxide. Nitric oxide dimer N2O2 is formed when nitric oxide is cooled. Nitric oxide reacts with ... Independent of nitric oxide synthase, an alternative pathway, coined the nitrate-nitrite-nitric oxide pathway, elevates nitric ...
The nitric oxide/cyclic GMP pathway in organ transplantation: Critical role in successful lung preservation (1994) Proceedings ... He is also the Samuel I. Belkin Chair, Professor and Chairman, Department of Cardiovascular and Thoracic Surgery, Professor and ... Indirect recognition of donor HLA-DR peptides in organ allograft rejection (1996) Journal of Clinical Investigation, 98 (5), pp ... Induction of myocardial nitric oxide synthase by cardiac allograft rejection (1994) Journal of Clinical Investigation, 94 (2), ...
... inducible nitric oxide synthase, proinflammatory nitric oxide (NO), and anti-apoptotic factors. Epidemiological studies have ... Pitchai Balakumar1 and Jagdeep Kaur, "Arsenic Exposure and Cardiovascular Disorders: An Overview", Cardiovascular Toxicology, ... S-adenosylmethionine (SAM) may serve as methyl donor. Various pathways are used, the principal route being dependent on the ... The effect on vascular endothelium may eventually be mediated by the arsenic-induced formation of nitric oxide. It was ...
Thomsen, L.L.; Kruuse, C.; Iversen, H.K.; Olesen, J. (1994). "A nitric oxide donor (nitroglycerin) triggers genuine migraine ... Klein, E.; Spencer, D. (Aug 2009). "Migraine frequency and risk of cardiovascular disease in women". Neurology. 73 (8): e42-e43 ... Research has revealed that nitric oxide (NO) and calcitonin gene-related peptide (CGRP) do have roles in the pathogenesis of a ... Olesen, J. (Nov 2008). "The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache". Pharmacology & ...
"Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis". Journal of cardiovascular pharmacology. 20 Suppl 12: ... The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in ... ADMA interferes with L-arginine in the production of nitric oxide (NO), a key chemical involved in normal endothelial function ... Statins, as well as affecting circulating cholesterol levels, also increase nitric oxide levels and so have a direct effect on ...
"Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in ... H2S therapy uses a H2S donor, such as diallyl trisulfide (DATS), to increase the supply of H2S to an AMI patient. H2S donors ... Independent of nitric oxide synthase, an alternative pathway, coined the nitrate-nitrite-nitric oxide pathway, elevates nitric ... In plants, nitric oxide can be produced by any of four routes: (i) L-arginine-dependent nitric oxide synthase, (although the ...
When soluble it functions as a receptor for nitric oxide (NO) (see figure 1). Formation of cGMP initiates several reactions in ... The pyrazolopyrimidinone of sildenafil mimics that of the guanine in cGMP and has the same H-bond donor and acceptor features, ... These drugs came out of research programs focusing on finding PDE5 inhibitors for the treatment of cardiovascular diseases and ... Possible mechanism is based on nitric oxide (NO)/cGMP transduction system as a central and peripheral mediator of inhibitory ...
... is thought to act as a donor for the synthesis of nitric oxide, a vasodilator. A review confirmed blood pressure lowering.[38] ... folate, to lower the risk of stroke and cardiovascular disease[118]. *multiple supplements for which there was no evidence of ... Rizos, EC; Elisaf, MS (June 2017). "Does Supplementation with Omega-3 PUFAs Add to the Prevention of Cardiovascular Disease?". ... For example, while increased consumption of fruits and vegetables are related to decreases in mortality, cardiovascular ...
Its effects are potentially similar to those of nitric oxide, whereby hydrogen sulfide may have an effect on cardiovascular ... In this model of the origin of life on Earth, geologically produced hydrogen sulfide is postulated as an electron donor driving ... Although both nitric oxide and hydrogen sulfide relax blood vessels in vitro, their mechanisms of action differ: nitric oxide ... metal oxides (e.g., Fe oxyhydroxides and Mn oxides) or nitrate as oxidant. The purple sulfur bacteria and the green sulfur ...
"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent". PNAS. 111 (Early ... H2S therapy uses a H2S donor, such as diallyl trisulfide (DATS), to increase the supply of H2S to an AMI patient. H2S donors ... hydrogen sulfide is now recognized as potentially protecting against cardiovascular disease. The cardioprotective role effect ... Though both nitric oxide (NO) and hydrogen sulfide have been shown to relax blood vessels, their mechanisms of action are ...
... and because free haemoglobin tends to take up nitric oxide, causing vasoconstriction. Efforts to overcome this toxicity have ... This blood will also serve as a blood donor to all blood types. Pharmed blood may be used in human trials in 2013. Artificial ... Yoffee, Lynn (May 1, 2008). "Oxycyte is on track as oxygen carrier, not as 'faux' blood". Cardiovascular Device & Drugs. ... address the chronic blood donor shortage, and address the concerns of Jehovah's Witnesses and others who have religious ...
Other possibilities of triptans in antimigraine effects are modulation of nitric oxide dependent signal transduction pathways, ... Dahlöf CG, Mathew N (1998). "Cardiovascular safety of 5HT1B/1D agonists--is there a cause for concern?". Cephalalgia : an ... donors are required not to have taken the medication for the last 72 hours.[citation needed] Triptans have few side effects if ... nitric oxide scavenging in the brain, and sodium dependent cell metabolic activity. Triptans have a wide variety of ...
... a biomarker for nitric oxide status (see below for Cardiovascular Disease, Nitric Oxide: a salivary biomarker for cardio- ... Complete List of Donor Screening Assays for Infectious Agents and HIV Diagnostic Assays. http://www.fda.gov/ ... nitric oxide synthase. An alternative pathway for the generation of nitric oxide is the nitrate-nitrite-nitric oxide pathway in ... A necessary and obligatory step in the generation of nitric oxide by the non-nitric oxide synthase or alternative pathway ...
Excessive nitric oxide produced during reperfusion reacts with superoxide to produce the potent reactive species peroxynitrite ... "Hydrogen sulfide donor protects against acute myocardial ischemia-reperfusion injury." Circulation 114(18):II172, 2006. Piot C ... A series of 2009 studies published in the Journal of Cardiovascular Pharmacology suggest that Metformin may prevent cardiac ... Activated endothelial cells produce more reactive oxygen species but less nitric oxide following reperfusion, and the imbalance ...
Thrombus formation on an intact endothelium is prevented by nitric oxide,[16] prostacyclin,[17] and CD39.[18] ... blood is taken from the donor, passed through a device which removes the platelets, and the remainder is returned to the donor ... evolutionary insight into human cardiovascular disease". Blood. 118 (13): 3661-9. doi:10.1182/blood-2011-02-338244. PMC 3186337 ... The intact endothelial lining inhibits platelet activation by producing nitric oxide, endothelial-ADPase, and PGI2 ( ...
Palmer RM; Ferrige AG; Moncada S (1987). "Nitric oxide release accounts for the biological activity of endothelium-derived ... blood is taken from the donor, passed through a device which removes the platelets, and the remainder is returned to the donor ... evolutionary insight into human cardiovascular disease". Blood. 118 (13): 3661-69. doi:10.1182/blood-2011-02-338244. PMC ... Thrombus formation on an intact endothelium is prevented by nitric oxide, prostacyclin, and CD39. Endothelial cells are ...
... converts arginine to citrulline and nitric oxide (NO).[1] Nitric oxide can diffuse through the plasma membrane into ... antinociceptive and cardiovascular effects". Br. J. Pharmacol. 110 (1): 219-24. doi:10.1111/j.1476-5381.1993.tb13795.x. PMC ... NO donors. (prodrugs). *Nitrates: Diethylene glycol dinitrate (DEGDN). *Erythritol tetranitrate (ETN). *Ethylene glycol ... which is activated by nitric oxide produced by eNOS. *tetrahydrobiopterin, cofactor to several enzymes including nitric oxide ...
Exposure of red blood cells to physiological levels of shear stress activates nitric oxide synthase and export of nitric oxide, ... Donated blood usually requires screening to ensure that donors do not contain risk factors for the presence of blood-borne ... This practice is hard to detect but may endanger the human cardiovascular system which is not equipped to deal with blood of ... Red blood cells can also synthesize nitric oxide enzymatically, using L-arginine as substrate, as do endothelial cells.[35] ...
negative regulation of nitric-oxide synthase activity. • negative regulation of mast cell activation. • cannabinoid signaling ... from various donor types". In Friedman H, Klein TW, Madden JJ. Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases. ... ranging from cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung ...
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide : An Overiew ". @inproceedings{ ... Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide : An Overiew "}, author={Meenakshi ... Controlled Delivery of Nitric Oxide for Cancer Therapy. *H Nezhad Alimoradi, Khaled Greish, Allan B Gamble, Gregory I. Giles ... Nitric oxide synthase expression and activity in cell models relevant to human pathophysiology. *Kristina Radić ...
Cardiovascular Diseases. Postoperative Complications. Nitric Oxide. Bronchodilator Agents. Autonomic Agents. Peripheral Nervous ... Will receive Nitric oxide and other standard inhaled anesthetics. Drug: Nitric Oxide Inhalation - 40 ppm, at the initiation of ... No Intervention: No nitric oxide This arm will not receive nitric oxide, but will receive other standard inhaled anesthetics ... Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transplantation. The ...
... donors in vivo is accompanied by a baroreflex-mediated increase in heart rate (HR). In vitro, however, NO donors can increase ... These results are also consistent with data in sinoatrial node cells that show that NO donors increase HR by stimulating I(f). ... The NO donor molsidomine (0.2 mg/kg iv) caused a progressive increase (Delta) in HR (DeltaHR, 14 +/- 3 beats/min; P , 0.01). ... NO donors exert a small, but significant, positive chronotropic effect in vivo that is independent of the autonomic nervous ...
Cardiovascular Diseases. Arteriosclerosis. Arterial Occlusive Diseases. Vascular Diseases. Nitric Oxide. Nitroglycerin. Nitric ... Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients With Coronary Artery Disease. This study has been ... Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients With Coronary Artery Disease. ... A molecule called nitric oxide (NO) appears to be involved in this release. However, some heart patients do not improve their ...
Research ArticleCARDIOVASCULAR. Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed ... Research ArticleCARDIOVASCULAR. Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed ... Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed Preconditioning in Rabbits. Renaud Tissier ... Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed Preconditioning in Rabbits ...
Research ArticleCARDIOVASCULAR. Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed ... Research ArticleCARDIOVASCULAR. Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed ... Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed Preconditioning in Rabbits. Renaud Tissier ... Accordingly, the efficacy of a nitric oxide (NO)-donor-induced delayed preconditioning was tested against ischemic insults of ...
Nitric Oxide Donors. Estradiols. VEGF. Gene Therapy. Antisense Approach. Principles of PDT. Therapeutic Angiogenesis. ... Textbook of Interventional Cardiovascular Pharmacology. 1st Edition. Edited by Nicolas Kipshidze, Jawad Fareed, Patrick W. ... Drug Interaction in Patients Undergoing Cardiovascular and Vascular Interventions. Newer Pharmacologic Approaches Targeting ...
Its releasing strategy is achieved by introducing exogenous NO storage materials like NO donors, while the generating strategy ... Nitric oxide (NO) has been proposed as a promising small molecule in improving the clinical performance of cardiovascular ... yet thrombosis and restenosis are the two major clinical complications which often lead to device failure.Nitric oxide (NO) has ... Its releasing strategy is achieved by introducing exogenous NO storage materials like NO donors, while the generating strategy ...
Nitric Oxide (NO) Donor Molecules: Effect of NO Release Rate on Vascular Smooth Muscle Cell Proliferation In Vitro. Mooradian, ... Recombinant Human Hemoglobin (rHb1.1) Selectively Inhibits Vasorelaxation Elicited by Nitric Oxide Donors in Rabbit Isolated ... Does the Antiarrhythmic Effect of Ischemie Preconditioning in Rats Involve the L-Arginine Nitric Oxide Pathway?. Lu, Hua Kong; ... Roles of Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor in Vasorelaxant Effect of Acetylcholine as Influenced by ...
people on nitric oxide donors, nitrates, and organic nitrites. *men who are advised to refrain from sexual intercourse because ... of cardiovascular risk factors. *people with severe liver impairment. *people with kidney disease ... nitric oxide is released by the nervous system in the erectile tissue of the penis. Nitric oxide stimulates an enzyme that ...
Keywords provided by Fundación Cardiovascular de Colombia: leishmaniasis. nitric oxide. treatment. donor. controlled trial. ... Drug: controlled nitric oxide releasing patch daily nitric oxide patch application during 20 days ... However, due to the unstable nitric oxide release, the topical donors needed to be applied frequently, making the adherence to ... The main objective of this study is to evaluate this novel nitric oxide topical donor for the treatment of cutaneous ...
Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... Abstract 1432: Nitric Oxide Bioavailability is Lower in Endothelium of Healthy Mexican American Donors as Compared to Non- ... Abstract 1432: Nitric Oxide Bioavailability is Lower in Endothelium of Healthy Mexican American Donors as Compared to Non- ... Abstract 1432: Nitric Oxide Bioavailability is Lower in Endothelium of Healthy Mexican American Donors as Compared to Non- ...
... responses elicited by a H2S donor (NaHS, sodium hydrogen sulphide) or inhibitors of CBS, microinjected into the RVLM and PVN. ... brain regions with key cardiovascular regulatory functions. The cardiovascular role of H2S was investigated by determining the ... The cardiovascular role of H2S was investigated by determining the blood pressure (BP), heart rate (HR) and lumbar sympathetic ... We also investigated the cardiovascular responses to NaHS microinjected into the RVLM and PVN in SHR rats. Again, there were no ...
Nitrates: Concomitant use with nitrates and nitric oxide donors in any form is contraindicated [see Contraindications (4.1)]. ... 5.1 Cardiovascular Effects. General Physicians should consider the cardiovascular status of their patients, since there is a ... nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme ... Administration with nitrates and nitric oxide donors (2.4, 4.1). *Administration with guanylate cyclase (GC) stimulators, such ...
N-nitroso-N-substituted hydroxylamines as nitric oxide donors. US5700286 *. 22 Ago 1996. 23 Dic 1997. Advanced Cardiovascular ... nitric oxide releasing agents, vasodilators, virus-mediated gene transfer agents, agents having a desirable therapeutic ... Advanced Cardiovascular Systems, Inc.. Polymer film for wrapping a stent structure. US5645931 *. 5 Jun 1995. 8 Jul 1997. Union ... Cardiovascular Dynamics, Inc.. Low profile perfusion catheter. US5571166 *. 15 Sep 1994. 5 Nov 1996. Medtronic, Inc.. Method of ...
1994) Therapeutic role of nitric oxide donors in the treatment of cardiovascular disease. Drugs Future 19:665-672. ... 1996) Donors of nitrogen oxides. in Methods in Nitric Oxide Research, eds Feelisch M., Stamler J. S. (Wiley and Sons Ltd. New ... 1995) Nitric oxide and the regulation of cerebral arterial tone. in Nitric Oxide in the Nervous System, ed Vincent S. (Academic ... 1996) Inhibitors of nitric oxide synthases. in Methods in Nitric Oxide Research, eds Feelisch M., Stamler J. S. (Wiley and Sons ...
Pretreatment with phlorizin or canagliflozin significantly inhibited sodium nitroprusside (SNP; a nitric oxide donor)-induced ... less information is available regarding the impact of SGLT2 inhibitors on cardiovascular outcomes. The present study was ...
Nitric oxide is an important messenger that regulates various physiological processes in the cardiovascular system. As the ... Donors of nitrogen oxides. In: Feelisch M, Stamler JS, eds. Methods in Nitric Oxide Research. New York, NY: John Wiley & Sons ... Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase. Am J Physiol. 1995; ... Direct Inhibition of Expressed Cardiac L-Type Ca2+ Channels by S-Nitrosothiol Nitric Oxide Donors. Hai Hu Nipavan Chiamvimonvat ...
... cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in ... D. Schwartz, M. Mendonca, I. Schwartz et al., "Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated ... A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by ... injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-EDV). Male Wistar rats were ...
The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a ... which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a ... into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. ... by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide ...
Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. LJ Ignarro, C Napoli, J ... Nitric oxide as a signaling molecule in the vascular system: an overview. LJ Ignarro, G Cirino, A Casini, C Napoli ... Nitric oxide and atherosclerosis: an update. C Napoli, F de Nigris, S Williams-Ignarro, O Pignalosa, V Sica, LJ Ignarro ... Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. C Napoli, LJ Ignarro ...
Inhaled nitric oxide and pentoxifylline in rat lung transplantation from non-heart-beating donors. Journal of Thoracic and ... Journal of Thoracic and Cardiovascular Surgery 1996; 112:590-8.. Chapelier A, Danel C, Mazmanian M, Bacha EA, Sellak H, Herve P ... Inhaled nitric oxide attenuates reperfusion injury in non-heart-beating donor lung transplantation. Transplantation 1997; 63: ... Prevention of reperfusion injury by inhaled nitric oxide in lungs harvested from non-heart-beating cadavers. Annals of Thoracic ...
Administration with nitrates and nitric oxide donors ( 2.4, 4.1) WARNINGS AND PRECAUTIONS • Cardiovascular Effects: Patients ... nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme ... A suitable time interval following STAXYN dosing for the safe administration of nitrates or nitric oxide donors has not been ... Administration of STAXYN with nitrates (either regularly and/or intermittently) and nitric oxide donors is contraindicated [see ...
Ignarro LJ, Napoli C, Loscalzo J. Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an ... Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J Immunol 1993; 151: ... Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase (NOS2) expression by wild-type p53. ... Regulation of Human Nitric Oxide Synthase 2 Expression by Wnt β-Catenin Signaling. Qiang Du, Kyung Soo Park, Zhong Guo, Peijun ...
COX-Inhibiting Nitric Oxide Donors (CINODs): Potential Benefits on Cardiovascular and Renal Function. Cardiovascular & ... The Future of Angiotensin II Inhibition in Cardiovascular Medicine. Current Drug Targets - Cardiovascular & Hematological ... Effects of Tea and Coffee Consumption on Cardiovascular Diseases and Relative Risk Factors: An Update. Current Pharmaceutical ...
  • Abstract NO donors have complex effects on Ca 2+ currents in native cardiac cells, with reports of direct stimulation and indirect cGMP-mediated inhibition or stimulation. (ahajournals.org)
  • Abstract -Nitric oxide (NO) donors were recently shown to produce biphasic contractile effects in cardiac tissue, with augmentation at low NO levels and depression at high NO levels. (ahajournals.org)
  • Yuan, Yang;Mohammad, Mahmoud A;Betancourt, Ancizar;Didelija, Inka C;Yallampalli, Chandrasekar;Marini, Juan C 2018-06-07 00:00:00 Abstract Background The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. (deepdyve.com)
  • Animal data suggest that nitric oxide (NO) acts as a neuromodulator not only within the central nervous system but also within peripheral autonomic pathways controlling cardiac function to provide a net enhancement of parasympathetic and inhibition of sympathetic control. (ahajournals.org)
  • Gadalla and Snyder, 2010 ), as is the case for the gaseous transmitter, nitric oxide. (frontiersin.org)
  • The disclosed methods include causing the mammal to inhale a therapeutically-effective concentration of gaseous nitric oxide (NO). Also disclosed are methods that include the administration. (google.com)
  • The disclosed methods include causing the mammal to inhale a therapeutically-effective concentration of gaseous nitric oxide (NO). Also disclosed are methods that include the administration of the following types of agents in conjunction with inhaled nitric oxide: compounds that potentiate the beneficial effects of inhaled nitric oxide, and antithrombotic agents that complement or supplement the beneficial effects of inhaled nitric oxide. (google.com)
  • In the last semicenturry, it has been proved that though low concentration of NO is tumor-promoting, high concentration of NO could exhibit multiple antitumor effects, which led to the research and development of kinds of NO donors and NO donor hybrid compounds as antitumor agents. (go.jp)
  • Herein, the recent development of NO donor hybrid compounds is briefly reviewed. (go.jp)
  • The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension. (sumobrain.com)
  • The present invention relates to nitric oxide donor compounds having a quinone based structure of formula (I), wherein R1 to R6, m, n and p are as defined in claim 1, to processes for their preparation and to their use in the treatment o. (sumobrain.com)
  • The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role. (sumobrain.com)
  • Nucleophile/NO adducts are a new class of compounds that spontaneously and predictively release NO. We investigated the hemodynamic effects of intravenous (i.v.) infusions of a recently developed NO-donor drug, the diethylamine-nitric oxide adduct (DEA/NO), in 17 intact newborn lambs. (elsevier.com)
  • Adducts of hydroxyguanidine compounds and nitric oxide: A novel class of NO donors. (naver.com)
  • This review presents the currently available data concerning epigenetic mechanisms and compounds involved in cardiovascular diseases, as well as preventive and therapeutic approaches against them. (beds.ac.uk)
  • Megson, IL & Webb, DJ 2002, ' Nitric oxide donor drugs: current status and future trends ', Expert Opinion on Investigational Drugs , vol. 11, no. 5, pp. 587-601. (uhi.ac.uk)
  • To investigate the molecular basis of these effects, we tested the effects of one class of NO donors, S -nitrosothiols (RSNOs), on expressed cardiovascular L-type Ca 2+ channels (α 1C ±β 1a ±α 2 or α 1C ±β 2a ±α 2 ) in human embryonic kidney (HEK293) cells. (ahajournals.org)
  • In this study, the researchers propose to investigate the efficacy of inhaled nitric oxide to prevent ischemia-reperfusion (I/R) hepatocyte injury in patients who receive extended donor criteria(EDC)liver grafts based on changes in proteomic and metabolomic markers following revascularization of the donor graft. (clinicaltrials.gov)
  • Accordingly, the efficacy of a nitric oxide (NO)-donor-induced delayed preconditioning was tested against ischemic insults of increasing duration. (aspetjournals.org)
  • This second mechanism of action makes naproxcinod the first in a new class of drugs, the cyclooxygenase inhibiting nitric oxide donators (CINODs), that are hoped to produce similar analgesic efficacy to traditional NSAIDs, but with less gastrointestinal and cardiovascular side effects. (wikipedia.org)
  • In the present study we have demonstrated the presence of the H 2 S-producing enzyme, cystathionine-β-synthase (CBS) in the rostral ventrolateral medulla (RVLM), and the hypothalamic paraventricular nucleus (PVN), brain regions with key cardiovascular regulatory functions. (frontiersin.org)
  • These data show that PDE-V is expressed in both the smooth muscle and endothelial cells of a resistance artery, and the enzyme can significantly influence nitric oxide-evoked vasorelaxation. (ox.ac.uk)
  • During 20 days Group 1 will receive simultaneously meglumine antimoniate and placebo of nitric oxide patches while Group 2 will receive placebo of meglumine antimoniate and active nitric oxide patches. (clinicaltrials.gov)
  • L-arginine is converted in the body into a chemical called nitric oxide. (webmd.com)
  • Responses were assessed during a background infusion of a nitric oxide synthase inhibitor ( N G -monomethyl- l -arginine [ l -NMMA]), placebo (saline), or phenylephrine (vasoconstrictor control) in a single-blind, random order, crossover protocol. (ahajournals.org)
  • Consequently, the interactions of N G -hydroxy- l-arginine with NO and other oxides of nitrogen (NOx) are of considerable interest. (naver.com)
  • Conclusion ADI-PEG20 successfully depleted circulating arginine without any effect on cardiovascular endpoints in healthy mice but limited NO production after endotoxin challenge. (deepdyve.com)
  • The NO donor arginine is a semiessential amino acid present in dietary proteins and produced in the body from citrulline, another semiessential amino acid. (life-enhancement.com)
  • Epidemiologic data as well as studies in ambulatory practice and intensive care settings have demonstrated increased risk of serious cardiovascular adverse events after severe hypoglycemia ( 3 - 5 ). (diabetesjournals.org)
  • These episodes were associated with serious cardiovascular adverse events and, in some trials, increased mortality ( 5 , 8 ). (diabetesjournals.org)
  • or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. (google.com)
  • Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue. (google.com)
  • 2. The method of claim 1 wherein the nitric oxide adduct is present in a matrix coating on a surface of the medical device which contacts a tissue within the patient, wherein the matrix coating is nylon or plastic. (google.com)
  • 3. The method of claim 2 wherein the matrix coating provides for release of the intact nitric oxide adduct. (google.com)
  • 5. The method of claim 1 wherein the nitric oxide adduct is coated per se on a surface of the medical device which contacts the vessel at the site of injury. (google.com)
  • 6. The method of claim 1 wherein the nitric oxide adduct is directly or indirectly bound to reactive sites on a surface of the medical device which contacts the vessel at the site of injury. (google.com)
  • 7. The method of claim 1 wherein at least a portion of the medical device is formed of a polymer which includes the nitric oxide adduct, wherein the polymer is nylon, polyethylene perthalate or polytetrafluoroethylene. (google.com)
  • 10. The method of claim 7 wherein the material provides for release of the intact nitric oxide adduct. (google.com)
  • 15. The method of claim 1 which comprises administering the nitric oxide adduct in combination with an anti-thrombogenic agent. (google.com)
  • In this study, we measured endothelial function in cells from normotensive, age-matched MA and NHW donors, as well as the effects of treatment with nebivolol, a new β 1 -selective blocker with vasodilating properties. (ahajournals.org)