Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Stephania tetrandra: A plant species of the genus STEPHANIA, family MENISPERMACEAE, that contains tetrandrine and bisbenzylisoquinoline alkaloids.Pongamia: A plant genus of the family FABACEAE. Members contain karanjin. Some species of this genus have been reclassified to other genera of FABACEAE including Callerya, DERRIS and MILLETTIA.Achyranthes: A plant genus of the family AMARANTHACEAE, order Caryophyllales, which has been used in traditional medicine (MEDICINE, CHINESE TRADITIONAL).AlloxanRubiaceae: The Madder plant family of the order Rubiales, subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.Hypoglycemic Agents: Substances which lower blood glucose levels.Vaccinium myrtillus: A plant species of the family VACCINIUM.Sympathomimetics: Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.Meprobamate: A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)Hypnotics and Sedatives: Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)Benzodiazepines: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.Basilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Carotid Artery Thrombosis: Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.Anticoagulants: Agents that prevent clotting.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Vertebrobasilar Insufficiency: Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Metabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Platelet Function Tests: Laboratory examination used to monitor and evaluate platelet function in a patient's blood.Cardiology: The study of the heart, its physiology, and its functions.Sleep Medicine Specialty: A medical specialty concerned with the diagnosis and treatment of SLEEP WAKE DISORDERS and their causes.Emergency Medicine: The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.Gastroenterology: A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Nephrology: A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Acute Coronary Syndrome: An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Purinergic P2Y Receptor Antagonists: Compounds that bind to and block the stimulation of PURINERGIC P2Y RECEPTORS. Included under this heading are antagonists for specific P2Y receptor subtypes.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Receptors, Purinergic P2Y12: A subclass of purinergic P2Y receptors that have a preference for ADP binding and are coupled to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI. The P2Y12 purinergic receptors are found in PLATELETS where they play an important role regulating PLATELET ACTIVATION.Pravastatin: An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Cholesterol, Dietary: Cholesterol present in food, especially in animal products.Anticholesteremic Agents: Substances used to lower plasma CHOLESTEROL levels.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Dermatitis, Atopic: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.Clinical Audit: A detailed review and evaluation of selected clinical records by qualified professional personnel to improve the quality of patient care and outcomes. The clinical audit was formally introduced in 1993 into the United Kingdom's National Health Service.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.

Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. (1/1571)

-The clinical efficacy of anthracycline antineoplastic agents is limited by a high incidence of severe and usually irreversible cardiac toxicity, the cause of which remains controversial. In primary cultures of neonatal and adult rat ventricular myocytes, we found that daunorubicin, at concentrations /=10 micromol/L induced necrotic cell death within 24 hours, with no changes characteristic of apoptosis. To determine whether reactive oxygen species play a role in daunorubicin-mediated apoptosis, we monitored the generation of hydrogen peroxide with dichlorofluorescein (DCF). However, daunorubicin (1 micromol/L) did not increase DCF fluorescence, nor were the antioxidants N-acetylcysteine or the combination of alpha-tocopherol and ascorbic acid able to prevent apoptosis. In contrast, dexrazoxane (10 micromol/L), known clinically to limit anthracycline cardiac toxicity, prevented daunorubicin-induced myocyte apoptosis, but not necrosis induced by higher anthracycline concentrations (>/=10 micromol/L). The antiapoptotic action of dexrazoxane was mimicked by the superoxide-dismutase mimetic porphyrin manganese(II/III)tetrakis(1-methyl-4-peridyl)porphyrin (50 micromol/L). The recognition that anthracycline-induced cardiac myocyte apoptosis, perhaps mediated by superoxide anion generation, occurs at concentrations well below those that result in myocyte necrosis, may aid in the design of new therapeutic strategies to limit the toxicity of these drugs.  (+info)

Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney. (2/1571)

The site of action of 3-(2,2,2-trimethylhydrazinium) propionate (THP), a new cardioprotective agent, was investigated in mice and rats. I.p. administration of THP decreased the concentrations of free carnitine and long-chain acylcarnitine in heart tissue. In isolated myocytes, THP inhibited free carnitine transport with a Ki of 1340 microM, which is considerably higher than the observed serum concentration of THP. The major cause of the decreased free carnitine concentration in heart was found to be the decreased serum concentration of free carnitine that resulted from the increased renal clearance of carnitine by THP. The estimated Ki of THP for inhibiting the reabsorption of free carnitine in kidneys was 52.2 microM, which is consistent with the serum THP concentration range. No inhibition of THP on the carnitine palmitoyltransferase activity in isolated mitochondrial fractions was observed. These results indicate that the principal site of action of THP as a cardioprotective agent is the carnitine transport carrier in the kidney, but not the carrier in the heart.  (+info)

Treatment patterns for heart failure in a primary care environment. (3/1571)

Little published information regarding current pharmacotherapeutic treatment patterns for congestive heart failure (CHF) in nonacademic, ambulatory care settings is available. We sought to assess, in a nonacademic primary care environment, pharmacotherapeutic treatment patterns for CHF with respect to consistency with clinical trial evidence and published treatment guideline recommendations. Over an 18-month period, we examined CHF pharmacotherapy using a computerized, integrated clinical diagnoses and prescription database from an outpatient community healthcare center without academic affiliations. We identified adult patients meeting contact criteria and with diagnosis of CHF by International Classification of Diseases (ICD-9-CM) coding and assessed prescribed therapy as well as select comorbid conditions. Drugs of interest included those with known or suspected benefit or detriment and those with unproven benefit. An eligible group of 14,983 patients was identified, from which a cohort of 148 patients with CHF was selected. Forty-one percent of these 148 patients were prescribed an angiotensin converting enzyme (ACE) inhibitor, 34% digoxin, 12% diuretic, 12% hydralazine + nitrate, 20% inhaled beta-agonists, and 66% warfarin. Only 5% of patients were prescribed the combination of an ACE inhibitor, digoxin, and diuretic. Thirty-one percent had a comorbid diagnosis of atrial fibrillation, of whom 44% were prescribed digoxin, 22% diltiazem, 15% beta-blockers, 15% digoxin and diltiazem, 7% digoxin and a beta-blocker, and 33% warfarin. In general, recommended therapies for CHF appeared underutilized in this cohort, whereas those of unclear benefit and potential detriment appeared overutilized. Although these results may not be readily generalized to the entire healthcare system, they do suggest a need for additional analysis and potential intervention.  (+info)

Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. (4/1571)

For the further elucidation of the central functions of nociceptin/orphanin FQ (noc/OFQ), the endogenous ligand of the G protein-coupled opioid receptor-like receptor ORL1, centrally acting specific antagonists will be most helpful. In this study it was found that the hexapeptide acetyl-RYYRIK-NH2 (Ac-RYYRIK-NH2), described in literature as partial agonist on ORL1 transfected in CHO cells, antagonizes the stimulation of [35S]-GTPgammaS binding to G proteins by noc/OFQ in membranes and sections of rat brain. The antagonism of the peptide was competitive, of high affinity (Schild constant 6.58 nM), and specific for noc/OFQ in that the stimulation of GTP binding by agonists for the mu-, delta-, and kappa-opioid receptor was not inhibited. The hexapeptide also fully inhibited the chronotropic effect of noc/OFQ on neonatal rat cardiomyocytes. It is suggested that Ac-RYYRIK-NH2 may provide a promising starting point for in vivo tests for antagonism of the action of noc/OFQ and for the further development of highly active and specific antagonists.  (+info)

Acute anti-ischemic effect of testosterone in men with coronary artery disease. (5/1571)

BACKGROUND: The role of testosterone on the development of coronary artery disease in men is controversial. The evidence that men have a greater incidence of coronary artery disease than women of a similar age suggests a possible causal role of testosterone. Conversely, recent studies have shown that the hormone improves endothelium-dependent relaxation of coronary arteries in men. Accordingly, the aim of the present study was to evaluate the effect of acute administration of testosterone on exercise-induced myocardial ischemia in men. METHODS AND RESULTS: After withdrawal of antianginal therapy, 14 men (mean age, 58+/-4 years) with coronary artery disease underwent 3 exercise tests according to the modified Bruce protocol on 3 different days (baseline and either testosterone or placebo given in a random order). The exercise tests were performed 30 minutes after administration of testosterone (2.5 mg IV in 5 minutes) or placebo. All patients showed at least 1-mm ST-segment depression during the baseline exercise test and after placebo, whereas only 10 patients had a positive exercise test after testosterone. Chest pain during exercise was reported by 12 patients during baseline and placebo exercise tests and by 8 patients after testosterone. Compared with placebo, testosterone increased time to 1-mm ST-segment depression (579+/-204 versus 471+/-210 seconds; P<0. 01) and total exercise time (631+/-180 versus 541+/-204 seconds; P<0. 01). Testosterone significantly increased heart rate at the onset of 1-mm ST-segment depression (135+/-12 versus 123+/-14 bpm; P<0.01) and at peak exercise (140+/-12 versus 132+/-12 bpm; P<0.01) and the rate-pressure product at the onset of 1-mm ST-segment depression (24 213+/-3750 versus 21 619+/-3542 mm Hgxbpm; P<0.05) and at peak exercise (26 746+/-3109 versus 22 527+/-5443 mm Hgxbpm; P<0.05). CONCLUSIONS: Short-term administration of testosterone induces a beneficial effect on exercise-induced myocardial ischemia in men with coronary artery disease. This effect may be related to a direct coronary-relaxing effect.  (+info)

Drug-induced heart failure. (6/1571)

Heart failure is a clinical syndrome that is predominantly caused by cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce heart failure in patients without concurrent cardiovascular disease or may precipitate the occurrence of heart failure in patients with preexisting left ventricular impairment. We reviewed the literature on drug-induced heart failure, using the MEDLINE database and lateral references. Successively, we discuss the potential role in the occurrence of heart failure of cytostatics, immunomodulating drugs, antidepressants, calcium channel blocking agents, nonsteroidal anti-inflammatory drugs, antiarrhythmics, beta-adrenoceptor blocking agents, anesthetics and some miscellaneous agents. Drug-induced heart failure may play a role in only a minority of the patients presenting with heart failure. Nevertheless, drug-induced heart failure should be regarded as a potentially preventable cause of heart failure, although sometimes other priorities do not offer therapeutic alternatives (e.g., anthracycline-induced cardiomyopathy). The awareness of clinicians of potential adverse effects on cardiac performance by several classes of drugs, particularly in patients with preexisting ventricular dysfunction, may contribute to timely diagnosis and prevention of drug-induced heart failure.  (+info)

Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice. (7/1571)

1. We investigated the cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor mice. The in vitro pharmacology of these agonists was determined at recombinant (human) alpha2-adrenoceptors and at endogenous (dog) alpha2A-adrenoceptors. 2. In wild-type mice, rilmenidine, moxonidine (100, 300 and 1000 microg kg(-1), i.v.) and clonidine (30, 100 and 300 microg kg(-1), i.v.) dose-dependently decreased blood pressure and heart rate. 3. In D79N alpha2A-adrenoceptor mice, responses to rilmenidine and moxonidine did not differ from vehicle control. Clonidine-induced hypotension was absent, but dose-dependent hypertension and bradycardia were observed. 4. In wild-type mice, responses to moxonidine (1 mg kg(-1), i.v.) were antagonized by the non-selective, non-imidazoline alpha2-adrenoceptor antagonist, RS-79948-197 (1 mg kg(-1), i.v.). 5. Affinity estimates (pKi) at human alpha2A-, alpha2B- and alpha2C-adrenoceptors, respectively, were: rilmenidine (5.80, 5.76 and 5.33), moxonidine (5.37, <5 and <5) and clonidine (7.21, 7.16 and 6.87). In a [35S]-GTPgammaS incorporation assay, moxonidine and clonidine were alpha2A-adrenoceptor agonists (pEC50/intrinsic activity relative to noradrenaline): moxonidine (5.74/0.85) and clonidine (7.57/0.32). 6. In dog saphenous vein, concentration-dependent contractions were observed (pEC50/intrinsic activity relative to noradrenaline): rilmenidine (5.83/0.70), moxonidine (6.48/0.98) and clonidine (7.22/0.83). Agonist-independent affinities were obtained with RS-79948-197. 7. Thus, expression of alpha2A-adrenoceptors is a prerequisite for the cardiovascular effects of moxonidine and rilmenidine in conscious mice. There was no evidence of I1-imidazoline receptor-mediated effects. The ability of these compounds to act as alpha2A-adrenoceptor agonists in vitro supports this conclusion.  (+info)

Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes. (8/1571)

We investigated effects of a novel cardioprotective drug, JTV-519 (4-[3-(4-benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahy dro-1,4-benzothiazepine monohydrochloride) on membrane currents of guinea pig ventricular myocytes by whole-cell voltage and current clamp methods. The fast Na+ current (iNa) was activated by ramp pulses from various holding potentials of -90, -80 or -60 mV to 10 mV with various intervals. At 0.2 Hz, JTV-519 inhibited iNa in a concentration-dependent manner with an IC50 of approximately 1.2 and 2 microM at the holding potential of -60 and -90 mM, respectively, implicating a voltage-dependent block. Increasing the pulse frequency from 1 to 2 or 3.3 Hz in the presence of 1 microM JTV-519 shortened the time-course and increased the level of iNa block, indicating a frequency-dependent block. The time-course of iNa blocking by JTV-519 was slower than that of lidocaine and similar to that of quinidine. Ca2+ current (iCa) and the inwardly rectifying K+ current (iK1) were also inhibited by JTV-519. JTV-519 decreased the duration and the height of the plateau of the action potential. We conclude that JTV-519 has frequency- and voltage-dependent blocking effects on iNa as well as inhibition of iCa and iK1.  (+info)

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... market worldwide is projected to grow by US$7.8 Billion, driven by a compounded growth of 1.4%. Renin-Angiotensin System Blockers, one - Market research report and industry analysis - 12779102
Every medication, basically have some risks or side effect potential. When taking any medication you must look at the benefits versus the risks. If th
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Albany, US, 2019-Jul-01 - /EPR Network/ -Cardiovascular drugs are widely used for treating various heart related dysfunction. With increasing number of cardiovascular diseases across the globe is the major driving factor for the growth of the cardiovascular diseases. According to the study conducted by Global Burden of Diseases estimate that the death rate due to CVD is 235 per 100000 in global population. According to WHO, cardiovascular diseases account for 31% deaths globally which is approximately 17.7 million individuals. Out of these 80% of the CVD deaths are due to stroke and heart attacks. Factors such as sedentary lifestyle, excess consumption of alcohol, stress, unhealthy eating habits, smoking are all factors responsible for the increase in the number of cardiovascular disorders among young population too.. Sample Report Access Source https://www.mrrse.com/sample/3877. The global cardiovascular drugs market report comprises an elaborate executive summary, which includes a market ...
Cardiovascular drug: Cardiovascular drug, any agent that affects the function of the heart and blood vessels. Drugs that act on the cardiovascular system are among the most widely used in medicine. Examples of disorders in which such drugs may be useful include hypertension (high blood pressure), angina pectoris (chest
Choudhry NK, Fischer MA, Avorn J, Liberman JN, Schneeweiss S, Pakes J, Brennan TA, Shrank WH. The implications of therapeutic complexity on adherence to cardiovascular medications [Internet]. Archives of Internal Medicine 2011;171:814-822.
This chapter reviews the basic and clinical pharmacology of cardiovascular drugs; focusing on practical, relevant points related to their pharmacokinetics, mechanisms of action, clinical use, and adverse effects. Despite the large number of available drugs used in the treatment of cardiovascular diseases, the most commonly used drugs are classified under a few categories of agents. The classification used in this chapter is based on the main mechanism of action of the drug. It should be noted that a single class of drugs can be used in treating more than one disease. As clarified in previous chapters, for managing a particular disease, there may be a number of drugs from different classes that can be used either alternatively, in combination, or during a particular stage of a disease. ...
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Cardiovascular Drugs indications,contraindications,composition,dosage and administration,properties and mode of action,precautions and side effects
Key Companies Covered in the Cardiovascular Drugs Market Research Report are Bristol-Myers Squibb Company, Pfizer Inc., Bayer AG, Janssen Pharmaceuticals, Inc., AstraZeneca, Sanofi, Novartis AG, Merck & Co., Inc., Gilead Sciences, Inc., F. Hoffmann-La Roche Ltd, among others.
This section of the report also includes market attractiveness analysis that provides a thorough analysis of the overall competitive scenario in the global cardiovascular drugs market across regions.
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EDITOR-We agree with Epstein that our study was unable to determine whether the participants had been appropriately prescribed cardiovascular drugs. This was not the aim of the study. He says that we may have underestimated the effect of cardiovascular drugs on the risk of falling because doctors may not prescribe these drugs to patients at greatest risk of falling, implying that our estimate of no effect on falls of cardiovascular drugs represents reduced … ...
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Cardiac disease in pregnancy 226Hypertension 228Arrhythmias 238Prosthetic heart valves 244Valvular heart disease 248Congenital heart disease 249Antibiotic prophylaxis peripartum 250Cardiomyopathy 251Ischaemic heart disease 253Cardiac disease is the leading cause of mortality in pregnancy, although overall only small numbers of women are affected. ...
Mouse is widely used in animal testing of cardiovascular disease. However, a large number of cardiovascular drugs that have been experimentally proved to work well on mouse were withdrawn because they caused adverse side effects in human. In this study, we investigate whether binding patterns of withdrawn cardiovascular drugs are conserved between mouse and human through computational dockings and molecular dynamic simulations. In addition, we also measured the level of conservation of gene expression patterns of the drug targets and their interacting partners by analyzing the microarray data. The results show that target proteins of withdrawn cardiovascular drugs are functionally conserved between human and mouse. However, all the binding patterns of withdrawn drugs we retrieved show striking difference due to sequence divergence in drug-binding pocket, mainly through loss or gain of hydrogen bond donors and distinct drug-binding pockets. The binding affinities of withdrawn drugs to their receptors
This is a huge class of drugs, accounting for a huge chunk of the drugs that we actually need to know well, and is one that the NCLEX and USMLE are going to ask you about. Lets break this class down into smaller, more manageable chunks. We will start with drugs used to treat Hypertension, as this class is very large and very important. First of all, take a look at the picture below for a summary of the drugs we will discuss ...
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The goal of this new part of the alliance is to leverage insights from human genetics to help create new cardiovascular therapies.
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To all those people out there wanting to take a new step in your fit life, to all those of you who want new and exciting challenges: Find an event or two you really think looks cool and exciting, register for it/them, and respect the hell out of it by taking your training seriously. I have seen way too many times people sign up for things and then arrogantly expect that they will probably be fine to just go and do the thing. This leads to all sorts of excuses for either not doing well or not finishing, like me in last years Regionals for the CrossFit Games. I didnt take my training seriously, I used moving back East as an excuse to skip training days and let my nutrition slide. And in the end, I finished 24th out of 30. yes, this is respectable from an objective standpoint, but I insulted all those athletes who trained their butts off by not taking my training more seriously I did not deserve to me there and I will NOT make that mistake again. Others may look up to you or respect you for just ...
by John Stonestreet Opinion Imagine for a moment youre a young, single mom. Youve just lost your job as a nanny for other peoples kids. Youre in a ...
The Bradley Lowery Foundation, named after the 5-year-old boy fighting a rare form of cancer, has already exceeded its £700,000 funding target
Ford Warriors in Pink has been active in the fight against breast cancer for the past 18 years. Shop for wear and gear and download your race photos.
Ford Warriors in Pink has been active in the fight against breast cancer for the past 18 years. Shop for wear and gear and download your race photos.
ROBERT C. KOEHLER FOR BUZZFLASH AT TRUTHOUT (Photo: Darmokand)The Ferguson tragedy, like all those that preceded it and all that will follow - involvi...
This style should give us courage but also encourage us to rethink. Many thanks to all who have continued working for us! For later years: Never forget what happened in 2020. We must all change our way of life! A Black-Norway-Red Style ...
I was only 25 when I was diagnosed, its been a year and a half since then, and sometimes I still feel overwhelmed about figuring out how to live the rest of my life with RA. Sometimes I wish I had gotten a chance to live more of my life without having to deal with this. I can only imagine it being even more difficult to be diagnosed four years younger, but Skye has shown a lot of courage in dealing with the changes life is throwing at her ...
Poisoning from sympathomimetic agents occurs secondary to the use of prescription and nonprescription agents. The public commonly uses prescription sympathomimetic agents, especially for treating diseases such as asthma and narcolepsy.
MEDICO REMEDIES PVT. LTD. - Manufacturer and Exporter of Cardiovascular Drugs like Atorvastatin Tablets,Enalapril Tablets etc from India.
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All cardiovascular agents were discontinued at least 7 days before cardiac catheterization. Several endomyocardial biopsy samples were obtained from the right side of the interventricular septum using the standard transfemoral technique. Biopsy samples were immediately frozen in liquid nitrogen and stored at −80°C until use.. PCR primers were designed according to the published sequences of c-myc, c-H-ras, β-MHC, and GAPDH cDNA.18 19 20 21 The nucleotide sequence used for each primer was as follows: for c-myc: 5′-primer (base 6731 to 6750), 5′-TCTGGATCACCTTCTGCTGG-3′; 3′-primer (base 6945 to 6964), 5′-CCTCTTGACATTTCTCCTCGG-3′; for c-H-ras: 5′-primer (base 132 to 152), 5′-GTGGTCATTG- ATGGGGATTC-3′; 3′-primer (base 378 to 398), 5′-GTCCTGAGCCTGCCGAGATTC-3′; for β-MHC: 5′-primer (base 1262 to 1282), 5′-GCAACGCAGAGTCGGTGAAGG-3′; 3′-primer (base 1433 to 1453), 5′-ACTTGGACAAGGTTGGTGTTGG-3′; and for GAPDH: 5′-primer (base 246 to 266), ...
All about ACEi and ARBS in Hypertension and Heart Failure (Current Cardiovascular Therapy) by Pasquale Perrone Filardi. LibraryThing is a cataloging and social networking site for booklovers
A composition for use in cardiovascular therapy includes transfer factor. The transfer factor may be nonmammalian transfer factor, such as that derived from eggs, or mammalian transfer factor, such as that derived from colostrum. The composition may also include one or more of the following: an LDL receptor-binding element; a blood flow-enhancing element; a cholesterol reducing element; a fat oxidation prevention element, and an antioxidant. Treatment methods include enlisting the immune system of a subject receiving therapy to attack pathogens that cause inflammation of blood vessels or to otherwise reduce inflammation of blood vessels.
Each patients medication that has the greatest quantity of pills on hand after randomization will be defined as the index medication and partial supplies will be provided for all other eligible medications in order to synchronize all of a patients medication. Prescribers will be contacted for a new prescription to ensure all eligible medications are on the same renewal schedule.. Randomization will occur within strata of whether patients are enrolled in the [email protected] program. Once synchronized, patients who are not enrolled in the [email protected] program will initiate their own refills. Patients who are enrolled in the [email protected] program will have their refills automatically filled, however patients may disenroll from [email protected] at any time, in which case they will initiate their own refills. Patients may disenroll in whole or in part from the program at any point. ...
Each patients medication that has the greatest quantity of pills on hand after randomization will be defined as the index medication and partial supplies will be provided for all other eligible medications in order to synchronize all of a patients medication. Prescribers will be contacted for a new prescription to ensure all eligible medications are on the same renewal schedule.. Randomization will occur within strata of whether patients are enrolled in the [email protected] program. Once synchronized, patients who are not enrolled in the [email protected] program will initiate their own refills. Patients who are enrolled in the [email protected] program will have their refills automatically filled, however patients may disenroll from [email protected] at any time, in which case they will initiate their own refills. Patients may disenroll in whole or in part from the program at any point. ...
The use of putative surrogate endpoints to bring potentially beneficial treatments to patients many years before the availability of clinical outcomes at relatively lower cost appeals to investors, scientists, and patients who hope to seek access to beneficial therapies (50). Yet, such shortcuts can have several well-documented unintended consequences, demanding direct measures of clinical outcomes that matter to patients. In cardiovascular medicine, both blood pressure and low-density lipoprotein levels have served as surrogates of important clinical outcomes under specific circumstances, but only after validation in multiple randomized clinical trials involving tens of thousands of patients (51,52). Success of the IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial), which demonstrated that low-density lipoprotein lowering with a combination of ezetimibe and simvastatin versus simvastatin alone resulted in improved long-term clinical outcomes, provides further ...
This literature review combined with clinical experience provides dosing recommendations for patients undergoing intermittent hemodialysis. The information presented could be beneficial for clinicians caring for patients in the hemodialysis units.
Author(s): Ganz, DA; Lamas, GA; Orav, EJ; Goldman, L; Gutierrez, PR; Mangione, CM | Abstract: BACKGROUND: Previous studies have suggested suboptimal use of cardiac medications for secondary prevention after myocardial infarction (MI) and atrial fibrillation (AF), especially among older people. OBJECTIVE: To determine whether patients older than 75 years are less likely than those aged 65 to 74 to be prescribed medications with evidence-based indications, including angiotensin-converting enzyme (ACE) inhibitors for left ventricular dysfunction (LVD) and/or diabetes mellitus (DM), aspirin and/or β-blockers for those with a history of MI, and warfarin for chronic AF. DESIGN: A retrospective cohort study. SETTING: Twenty-nine hospitals, predominantly tertiary-care institutions. PARTICIPANTS: A total of 407 patients randomized to ventricular or dual-chamber pacing from February 26, 1993, to September 30, 1994, in the Pacemaker Selection in the Elderly (PASE) trial. MEASUREMENTS: A review of the patients
One step at a time" is how Brigid Collins and Jim Stewart plan to create a bereavement center for children on the East End. They took a giant leap in that direction in October, when they secured not-for-profit status for Katys Courage Fund, named for their daughter, who died of hepatoblastoma, a rare form of liver cancer. The third Annual Katys Courage 5K race, which celebrates Katy and furthers her familys progress toward their goal, will take place in Sag Harbor on April 13 ...
If anyone should seek the real definition of courage, let them not look for it in philosophical discourses or the annals of military history. Let them read these words from Reeyot and apply them to their cause.. But I often wonder: What makes individuals like Reeyot do what they do while the rest of us do very little or nothing? Were they born with courage or did they acquire it; and if so how and where? Was courage thrust upon them by circumstances? Why is it a moral imperative for Reeyot and others like her to "dream of things that never were, and ask why not" when many of us "look at things the way they are, and ask why?". Why did Reeyot defiantly declare from prison, "I believe that I must contribute something to bring a better future [in Ethiopia]" while many of us sit comfortably in freedom and are only concerned about contributions to bettering ourselves? Why did she resolutely proclaim, "I always stand firmly for my principle and profession."? Why would she plead with the world, "Please, ...
In their quest to treat cardiovascular disease, researchers have been interested in developing new medicines that activate a protein called APJ. Publishing July 18 in Nature, researchers at Sanford-Burnham Medical Research Institute and the Stanford University School of Medicine uncovered another function for APJ -- it senses mechanical changes that set the body on a course toward heart failure. This means activating APJ could be harmful in some cases -- potentially eye-opening information for some drug makers.
DUBLIN, Sept. 15, 2017 /PRNewswire/ -- The Cardiovascular Drug Delivery - Technologies, Markets and Companies report from Jain PharmaBiotech has been adde...
A simple, economical and robust analytical high-performance liquid chromatography-ultraviolet method was developed and validated for simultaneous chromatographic elution of two car..
BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they - and only they - are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called specializations in [81. Entity doesnt have a closure axiom because the subclasses dont necessarily exhaust all possibilites. For example Werner Ceusters portions of reality ...
PHARMASYR is a Syrian pharmaceutical company, licenced by Syrian Ministry of Health. It was established in 1990, and started production in 1994.. ...
BioWorld Online is the news service of record for the biotechnology industry and is updated every business morning. BioWorld Online will keep you up to date on all of the industrys business, science and regulatory news -- mergers and collaborations, FDA hearings and results, breakthroughs in research and much more.
Introduction. To what extent do you agree that in Regeneration Barker question the notion of Heroism in wartime? Courage is generic, denoting fearlessness or defiance of danger; fortitude is passive courage, the habit of bearing up nobly under trials, danger, and sufferings; bravery is courage displayed in daring acts; valor is courage in battle or other conflicts with living opponents; intrepidity is firm courage, which shrinks not amid the most appalling dangers; gallantry is adventurous courage, dashing into the thickest of the fight. Heroism may call into exercise all these modifications of courage. It is a contempt of danger, not from ignorance or inconsiderate levity, but from a noble devotion to some great cause, and a just confidence of being able to meet danger in the spirit of such a cause. There are many different ways in which to show heroism, yet in this context there are only two, the first is contemporary societys definition of heroism, being that of someone who shows selfless ...
For patients with type 2 diabetes and coronary artery disease, CABG plus optimal medical therapy is superior to PCI plus optimal medical therapy.
Its no secret that certain drugs can interact with each other. What you may not know is that certain everyday foods and over-the-counter (OTC) remedies can also interact with cardiovascular medications, sometimes with serious health...
A reading worksheet for assigning Profiles in Courage projects & homework assignments. Part of a comprehensive Lesson Plan from BookRags.com.
In this short literature-based unit, students read about African Americans who exemplified courage in very tumultuous times of their lives.
BRAVO Principals Act With Courage, Conviction Making difficult decisions requires courage. A principals acts of courage help ensure that all children learn. Those acts also serve as catalysts; they motivate colleagues to act with courage. Included: Sandra Harris offers ten actions of courageous principals.
When we are not in touch with the way we feel, then it is possible for these hidden feelings to twist and falsify our thoughts. It takes courage to listen to the thoughts within our heart, because it often speaks from a space of emotions that we are uncomfortable, wary or scared of. But if we are to think truly and clearly (with both our heart and head) then we need to be deeply congruent with the way we are feeling at all times. Because this takes courage, or Lion-heartedness it is possible to think of courage as the root of all virtues. As Winston Churchill famously said "Courage is rightly esteemed the first of human qualities… because it is the quality which guarantees all others.". Listening to the voice of your heart-mind ...
Courage is a American Stout style beer brewed by Grateful Hands Brewing in Cabot, VT. 3.82 average with 7 ratings, reviews and opinions.
Film Courage: Keith I understand you had distribution for THE MASON BROTHERS during production? Is that right? Keith Sutliff: Right. We had a pre-sales deal ...
It isnt courage. I dont really know why people say that. Courage is jumping into a lake to save someone when you have the choice not to. What is my choice? To lie in bed all day and moan? Not really. Im not that badly off. Not compared to some people. So I would never say its courage. Character, yes. Fortitude, sure, OK. You just keep going. One step after the other, just the way you always have. Sure, its a little more challenging, and, sure, I feel a little more cranky at times, and have way less patience with those who are self-indulgent. So you have a cold and your nose is dripping? Get a Kleenex! I am also, paradoxically, more patient and understanding in many ways ...
It isnt courage. I dont really know why people say that. Courage is jumping into a lake to save someone when you have the choice not to. What is my choice? To lie in bed all day and moan? Not really. Im not that badly off. Not compared to some people. So I would never say its courage. Character, yes. Fortitude, sure, OK. You just keep going. One step after the other, just the way you always have. Sure, its a little more challenging, and, sure, I feel a little more cranky at times, and have way less patience with those who are self-indulgent. So you have a cold and your nose is dripping? Get a Kleenex! I am also, paradoxically, more patient and understanding in many ways ...
Expert Review of Cardiovascular Therapy, December 2014, Vol. 12 Issue: Number 12 p1439-1453, 15p. Abstract: Reference values (RV) for cardiopulmonary exercise testing (CPET) provide the comparative basis for ...
Page contains details about bioresorbable electronic stent . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
To those who may not know this, I was with my ex from the time I was 16 until 2009, which of course we still were seeing each other because I got pregnant with Isaiah in 2010. Well after finding out he had gotten married I was done with him, he still lied to me about it of course. Hed say anything just to keep me around, but I wised up thank God. I do give credit to Kayden for that strength to push me through those hard months following and accepting things as they were. During the relationship with him, it was good at first, as all relationships are. He did cheat on me right when we first got together and I did almost just say forget it then, but if I did I wouldnt have my 4 amazing children. So I decided we can try this thing again, things were so good for awhile, we got pregnant in December 2004, at my appt in February, we found out our first baby had no heart beat, I was around 9 weeks and lost the baby March 1, 2005. I was 17 when I lost my first child. Things were going good and ...
To those who may not know this, I was with my ex from the time I was 16 until 2009, which of course we still were seeing each other because I got pregnant with Isaiah in 2010. Well after finding out he had gotten married I was done with him, he still lied to me about it of course. Hed say anything just to keep me around, but I wised up thank God. I do give credit to Kayden for that strength to push me through those hard months following and accepting things as they were. During the relationship with him, it was good at first, as all relationships are. He did cheat on me right when we first got together and I did almost just say forget it then, but if I did I wouldnt have my 4 amazing children. So I decided we can try this thing again, things were so good for awhile, we got pregnant in December 2004, at my appt in February, we found out our first baby had no heart beat, I was around 9 weeks and lost the baby March 1, 2005. I was 17 when I lost my first child. Things were going good and ...
One of executive managements central responsibilities is the design and timely execution of strategy. For directors, it is to challenge, vet and ultimately ratify that strategy.
Is every child my child? Does ideology end at the bedside of a sick child? I ponder those questions every day when I watch the bravest person I know - my granddaughter. Consider this:
answers to them at first. Thats where courage comes in! Eleanor Roosevelt understood this when she said, You gain strength, courage, and confidence by every...which you really stop to look fear in the face You must do the thing which you think you cannot do. 131 Do you know what you are here to do? If not ...
It took getting diagnosed with endometriosis for me to learn to the importance of finding a good doctor and opening up about my symptoms.
This is a difficult article to write. The reason is I am going to be blunt about not having a voice, or being able to talk in my mind and being the only person that can understand what is being said. All our lives being able to talk to others is taken for granted. It…
Every time Katie Collier takes the court for the University of Washington next year, shell serve as a role model for overcoming an almost unthinkable level of adversity. On Sept...
GORDON and Sarah Brown frequently held their dying daughter, stroking her and talking to her as she lost her fight for life, the consultant who looked after Jennifer Jane said yesterday.
Mildroxyn information about active ingredients, pharmaceutical forms and doses by Makiz-Pharma, Mildroxyn indications, usages and related health products lists
Ethan is so amazing, he is a people person. He prefers people to objects and from his earliest days this really showed. Even before the shunt was in place and it was difficult for him to look up from the pressure. Right before the Christening in October, Ethan had his shunt installed. Less than a week later you can see him look easily at his God-mother. God has blessed us with Ethan and Ethan is blessed with many loving and caring people in his life. It is a very emotional to have a child born with a birth defect. From the moment you know your life is changed. You are dealing with something completely out of your control. It is events like these that really challenge your faith into action. Looking back you know what a blessing it is. Our strength comes from God, He provides the strength and courage to face all challenges. And brings wonderful people along side you for support ...
Since the release of Angelina Jolies revelation of her medical condition in the New York Times op-ed, it has naturally been all over the media. As many have said, It took a lot of courage to disclose such a private matter, especially being such a high-profile person. Everyone must make choices in their life. And, the…
Bonnie Moebeck shares her story of overcoming physical adversities to find opportunity, adventure and courage at the Leadville Trail 100 MTB.
I was in the car the other day and I thought "WOW how my life has changed". It used to be Juwan and me; coming & going as we pleased, going to bed whenever we wanted, jumping up at the drop of a dime to go to dinner, now all that is changed. Most families take about 2 months for their lives to return to "normal". My normal has changed. I dont really feel comfortable having Mylah out in public. I dont feel comfortable leaving her with anyone other than her father no matter how much help we are offered. I dont have any desire to leave the house really, it just doesnt feel right. Id be lying if I said I didnt go through the motions in my mind and ask myself if I had it to do it over again would I make the same decision; I never work up the courage to answer the question I ask myself, because on my more emotional days, Im afraid of what the answer would be ...
Hes back inside from around 9am to around 8pm. I still havent tried to introduce him to the inside cats yet, I still want to do that, but am afraid of the possibly nasty fights. One day, Ill get the courage to try formal introductions. It would be lovely for him to be integrated into the general population. Oh, but then theres still that pesky spraying issue ...
Weeks after deciding to try a life experiment that I call The Year of Living Courageously, I was confronted with a situation requiring more courage, and a kind
While not everyone who hits rock bottom summons the courage to stand back up, the ones who do are often greatest and most successful amongst us.
Hello fellow ATS peeps its so good to finally pluck up the courage to come on here, it has been a long time coming. ATS has so many beautiful and intelligent minds and is by far (in my opinion) the best conspiracy website out there. This place really inspires me to learn more about everything this universe has to offer ...
Resilience is our ability to recover quickly from setbacks, but it is also much more. Resilience allows you to tap into your strength and courage so you can persevere when things dont go as you had p
We showed that the doughnut hole significantly influences a patients decision to obtain cardiovascular medications. Research in other types of drug benefits suggests the potential for prescriptions to be delayed, switched to another product, or stopped completely when patients are faced with a change in the dynamic of their drug coverage (Gellad et al 2006, Gibson et al 2005, Soumerai et al 2006, Goldman et al 2004, Joyce et al 2002, Huskamp et al 2005, Cox et al 2001, Stuart et al 2005, Rector et al 2004, Hales 2009, Kaiser Family Foundation 2008). Current estimates have the doughnut holes entrance level surpassing $6,000 by the year 2016 (NCPSSM 2008). Therefore, it is important to understand how changes in benefit design affect prescription fulfillment behaviors - and to do so specifically for particular disease states.. Our study populations had a high number of different medications - 17.1 +/- 6.97 SD and 16. 4 +/- 6.48 SD for stand-alone PDP and MA-PD members, respectively. This compares ...
A Prospective Randomized Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS element) for the Treatment of up to Two De Novo Coronary Artery Lesions - PLATINUM Trial
Proton-Coupled Electron-Transfer Mechanism for the Radical Scavenging Activity of Cardiovascular Drug Dipyridamole. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Cardiovascular drugs attenuated myocardial resistance against ischaemia-induced and reperfusion-induced injury in a rat model of repetitive occlusion ...
Propranolol is a competitive antagonist which specifically competes with beta-adrenergic. by sufficient doses of such agonists as isoproterenol or dobutamine.Hemodynamic Effects of Atropine, Dobutamine, Nitroprusside, Phenylephrine, and Propranolol in Conscious Horses.. Antimigraine, Cardiovascular Agent (About this - PubMed Health).Medications that have been reported to negatively interact with propranolol include clonidine, digitalis, dobutamine, haloperidol, isoproterenol, blood ...
Dartmouth-Hitchcock Concord | Cardiovascular Medicine is a Cardiologist at 253 Pleasant Street, Concord, NH 03301. Wellness.com provides reviews, contact information, driving directions and the phone number for Dartmouth-Hitchcock Concord | Cardiovascular Medicine in Concord, NH.
... is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine.. ...
This head-to-head noninferiority trial is comparing the efficacy and tolerability of a platinum chromium everolimus-eluting coronary stent system [PROMUS
Cardiology Research and Cardiovascular Medicine is an open-access scientific journal, reviewed by experts, which publishes articles related to diagnosis and problems related to cardiovascular diseases.
For the cardiovascular system[edit]. *General: β-receptor blockers ("beta blockers"), calcium channel blockers, diuretics, ... antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
Volume 3: Cardiovascular Agents and Endocrines (6th ed.). Hoboken, N.J.: Wiley. ISBN 9780471270904. "Merck's Plendil ( ...
Some agents are more likely to cause complications than others but all sedative agents can cause complications if not used ... Cardiovascular Function. Unaffected. Usually maintained. Usually maintained. May be impaired There is another type of sedation ... Additionally, some agents have antagonists, reversal agents, that can be used to reverse the effects or reduce the amount of ... Sedative agents[edit]. Propofol[edit]. Propofol[5] is a non-barbiturate derivative that is thought to act by stimulating ...
Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... No evidence for a possible hepatic or cardiovascular toxicity was found.. History[edit]. Irreversible MAOI antidepressants were ... when cardiovascular toxicity is a concern, SSRIs or the reversible MAOIs such as moclobemide are an option as they lack or have ... moclobemide has been recommended as a first line agent for the treatment of depression in the elderly.[55] Due to the side ...
"4D flow cardiovascular magnetic resonance consensus Statement, Dyverfeldt et. al". Journal of Cardiovascular Magnetic Resonance ... Visualising heart muscle scar or fat without using a contrast agent[edit]. Typically a sequence called spin echo is used. This ... Cardiovascular magnetic resonance imaging (CMR), sometimes known as cardiac MRI, is a medical imaging technology for the non- ... Cardiovascular MRI. Ventriculography Radionuclide ventriculography. Cardiac catheterization/Coronary catheterization. Cardiac ...
Cardiovascular system[edit]. Cardiac toxicity can result from improper injection of agent into a vessel. Even with proper ... Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is used as a reducing agent ... LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... This can be a factor in choosing an agent in patients with liver failure,[56] although since cholinesterases are produced in ...
Brook I (2009). "Pericarditis caused by anaerobic bacteria". Int J Antimicrob Agents: 297-300. Ibe, Tatsuro; Nakamura, Tomohiro ... Cardiovascular Medicine. p. 64. ISBN 9781934465288. Archived from the original on 2010-08-02. "Pericarditis". nhlbi.nih.gov. ... The classic sign of pericarditis is a friction rub heard with a stethoscope on the cardiovascular examination usually on the ... Cardiovascular Imaging. 17 (6): 707-707. doi:10.1093/ehjci/jew056. PMID 27044912. Atallah, Pierre Charbel; Kassier, Adnan; ...
82-. ISBN 978-0-8493-4724-5. Dennis V. Cokkinos (6 November 2014). Introduction to Translational Cardiovascular Research. ... Pharmaceutical Chemistry of Antihypertensive Agents. CRC Press. pp. ...
Farmer JA (1998). "Aggressive lipid therapy in the statin era". Progress in Cardiovascular Diseases. 41 (2): 71-94. doi:10.1016 ... Stüve O, Youssef S, Steinman L, Zamvil SS (Jun 2003). "Statins as potential therapeutic agents in neuroinflammatory disorders ... Cardiovascular & Haematological Disorders. 5 (2): 127-34. doi:10.2174/1568006043586198. PMID 15853754. Sorrentino S, Landmesser ... are used to lower serum cholesterol as a means of reducing the risk for cardiovascular disease. These drugs include ...
Cardiovascular & Hematological Agents in Medicinal Chemistry. 4 (1): 17-32. doi:10.2174/187152506775268758. Ernsberger, P; ... novel agents and therapeutic potential". Cardiovasc Hematol Agents Med Chem. 4 (1): 17-32. doi:10.2174/187152506775268758. PMID ... doi:10.1111/j.1749-6632.1999.tb09388.x. Head, G.; Mayorov, D. (1 January 2006). "Imidazoline Receptors, Novel Agents and ... Bousquet, P (November 2001). "I1 receptors, cardiovascular function, and metabolism". American journal of hypertension. 14 (11 ...
Yeung J, Holinstat M (July 2011). "12-lipoxygenase: a potential target for novel anti-platelet therapeutics". Cardiovascular & ... HETE metabolic pathway has dual functions in promoting or inhibiting platelet responses depending on the stimulating agent and ... Hematological Agents in Medicinal Chemistry. 9 (3): 154-64. doi:10.2174/187152511797037619. PMC 3171607 . PMID 21838667. ...
The choice of which agent to use should be based on the prescribing clinician's experience with a particular agent, its cost, ... There is also an increased risk for cardiovascular complications, including hypertension and ischemic heart disease, and kidney ... Duley L, Henderson-Smart DJ, Meher S, King JF (2007). "Antiplatelet agents for preventing pre-eclampsia and its complications ... McDonald SD, Malinowski A, Zhou Q, Yusuf S, Devereaux PJ (2008). "Cardiovascular sequelae of preeclampsia/eclampsia: a ...
April 2010). "Cardiovascular risks of anemia correction with erythrocyte stimulating agents: should blood viscosity be ... Many conventional cardiovascular risk factors have been independently linked to whole blood viscosity. Anemia can reduce blood ... With the development of cardiovascular prosthetic devices such as heart valves and blood pumps, the understanding of pulsating ... These functions of the cardiovascular system are directly related to vascular resistance, preload, afterload, and perfusion, ...
Cardiovascular disease[edit]. Adult exposure to PAHs has been linked to cardiovascular disease.[63] PAHs are among the complex ... "Air pollution combustion emissions: Characterization of causative agents and mechanisms associated with cancer, reproductive, ... Cancer is a primary human health risk of exposure to PAHs.[51] Exposure to PAHs has also been linked with cardiovascular ... Oxidative stress following PAH exposure could also result in cardiovascular disease by causing inflammation, which has been ...
Cohen A, Hernandez CM (1976). "Nefopam hydrochloride: new analgesic agent". The Journal of International Medical Research. 4 (2 ... managing cardiovascular complications with beta blockers and limiting absorption with activated charcoal.[19] ... It has additive anticholinergic and sympathomimetic effects with other agents with these properties.[19] Its use should be ... See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine ...
Understanding of the molecular basis of binding to integrins has enabled the development of several drugs for cardiovascular ... Design, Synthesis and Clinical Evaluation". Anti-Cancer Agents in Medicinal Chemistry. 10 (10). Ley, Klaus; Rivera-Nieves, ... Zeymer, Uwe; Wienbergen, Harm (2007-12-01). "A Review of Clinical Trials with Eptifibatide in Cardiology". Cardiovascular Drug ... Kloner, Robert A. (2013-08-02). "Current State of Clinical Translation of Cardioprotective Agents for Acute Myocardial ...
L. N. Yakhontov, S. S. Liberman (March 1987). "Agents for the treatment of cardiovascular diseases". Pharmaceutical Chemistry ...
CO may play a role as potential therapeutic agent. In mammals, carbon monoxide is naturally produced by the action of heme ... Wang XB, Jin HF, Tang CS, Du JB (16 Nov 2011). "The biological effect of endogenous sulfur dioxide in the cardiovascular system ... Tian H. (Nov 2014). "Advances in the study on endogenous sulfur dioxide in the cardiovascular system". Chin Med J. 127 (21): ... Endogenous sulfur dioxide is also a potent antiinflammatory, antioxidant and cytoprotective agent. It lowers blood pressure and ...
CO may play a role as potential therapeutic agent. In mammals, carbon monoxide is naturally produced by the action of heme ... CO modulates functions of the cardiovascular system. CO inhibits blood platelet aggregation and adhesion. ... carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation-a tale of three gases!". Pharmacology & ...
"Part 6: Advanced Cardiovascular Life Support Section 6: Pharmacology II: Agents to Optimize Cardiac Output and Blood Pressure ... Mark S, Link; Lauren C, Berkow; Peter J, Kudenchuk (2015). "Part 7: Adult Advanced Cardiovascular Life Support - Figures and ... contrast agents, medicines or people with a history of anaphylactic reactions to known triggers. A single dose is recommended ... adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and ...
"Cardiovascular events and death in children exposed and unexposed to ADHD agents". Pediatrics. 127 (6): 1102-10. PMID 21576311. ... "ADHD medications and risk of serious cardiovascular events in young and middle-aged adults". JAMA. 306 (24): 2673-83. PMID ...
"Comprehensive review of cardiovascular toxicity of drugs and related agents". Medicinal Research Reviews. 38 (4): 1332-1403. ... Risk of overdose is increased in patients taking multiple serotonergic agents or interacting agents. ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ... Combination of mechanisms of action in a single active agent is an important development in psychopharmacology.[35] ...
Dose adjustments of either class of agent may be necessary. Imdur (isosorbide-5-mononitrate) is a nitrate preparation for ... angina pectoris Archived 2007-06-22 at the Wayback Machine., AstraZeneca Cardiovascular] Shrikant Bollapragada; Fiona Mackenzie ...
Volume 3: Cardiovascular Agents and Endocrines (6th ed.). Wiley. pp. 55-154. ISBN 978-0471370291. LoSalt Advisory Statement ( ... Smith Kline & French launched it as a single agent under the brand Dyrenium in 1964. The combination drug with ... Fink, Cynthia A; McKenna, Jeffrey M.; Werner, Lincoln H. (2003). "Diuretic and Uricosuric Agents". In Abraham, Donald J. ... 1962). "Triamterene, A New Natruretic Agent: Preliminary Observations in Man". Ann Intern Med. 56: 241-251. doi:10.7326/0003- ...
Hypoxia, acidosis, hyperkalemia are also negative inotropic agents. Cardiovascular System Dynamics Society Betts, J. Gordon ( ... The heart functions as a pump and acts as a double pump in the cardiovascular system to provide a continuous circulation of ... The cardiovascular centres receive input from a series of visceral receptors with impulses traveling through visceral sensory ... The cardiovascular centres monitor these increased rates of firing, suppressing parasympathetic stimulation or increasing ...
... the choice of an agent depends on the patient's cholesterol profile, cardiovascular risk, and the liver and kidney functions of ... Hypolipidemic agents, cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are ... Investigational classes of hypolipidemic agents: *CETP inhibitors (cholesteryl ester transfer protein), 1 candidate is in ... "Clinical evaluation of lecithin as a lipid-lowering agent". Phytotherapy Research. 9 (8): 597-599. doi:10.1002/ptr.2650090814. ...
Could certain agents provide cardiovascular benefits as well? ... Diabetes mellitus is a major risk factor for cardiovascular (CV ... Cardiovascular (CV) outcome trials for newer antihyperglycemic agents have shown significant CV benefit of using certain ... CV cardiovascular, CVD cardiovascular disease, DPP-4 dipeptidyl peptidase-4, GLP-1 glucagon-like peptide-1, HbA1c glycated ... CV cardiovascular, DPP-4 dipeptidyl peptidase-4, GLP-1 glucagon-like peptide-1, HF heart failure, MI myocardial infarction, ...
The public commonly uses prescription sympathomimetic agents, especially for treating diseases such as asthma and narcolepsy. ... Poisoning from sympathomimetic agents occurs secondary to the use of prescription and nonprescription agents. ... easily titrated agent (eg, nitroprusside) if it is not controlled with benzodiazepine-induced sedation. ... Cardiovascular effects of cocaine. Circulation. 2010 Dec 14. 122(24):2558-69. [Medline]. ...
Anticoagulants, Cardiovascular. Class Summary. These agents prevent recurrent or ongoing thromboembolic occlusion. ... Diuretic Agents. Class Summary. Diuretics can be useful to reduce the amount of ascites, providing symptomatic relief and ... Antifibrinolytic Agents. Class Summary. Fibrinolytic drugs are used to dissolve a pathologic intraluminal thrombus or embolus ... This agent is often preferred because of its potassium-sparing effects, particularly in a clinical setting that includes ...
have been trying to find current information on Viet Nam Veterans and the effect Agent Orange had on them. My father died in ... My father died in 1991 at age 60 after 2 1/2 years of terrible illness which I attribute to Agent Orange. He was a career ... I have attempted to look online to find a connection between Agent Orange and the hypotension and cannot find any information. ... Im not sure what type of info you are searching for, but if you Google hypotension Agent Orange on the second page there is ...
Cardiovascular, Other. Class Summary. It may be necessary to use antiarrhythmic agents for concomitant tachyarrhythmia. ... Anticholinergic Agents. Class Summary. Atropine, by vagolytic effect, increases the heart rate. Although it may also be used ... Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian ... Justin D Pearlman, MD, PhD, ME, MA Director of Advanced Cardiovascular Imaging, Professor of Medicine, Professor of Radiology, ...
Cardiovascular agents. Class Summary. These agents are used for symptomatic bradycardia and/or hypotension. Catecholamines are ... Agents with combined alpha- and beta-selective properties may be necessary to maintain blood pressure. A beta-agonist may ... Agents with combined alpha- and beta-selective properties may be necessary to maintain blood pressure. A beta-agonist may ... This agent stimulates production of cyclic adenosine monophosphate (cAMP) through nonadrenergic pathways. Result is enhanced ...
Antiplatelet Agents, Cardiovascular. Class Summary. Antiplatelet agents inhibit the cyclo-oxygenase system, decreasing the ... Anticoagulant Agents. Class Summary. The rationale for the use of these agents is to prevent recurrent embolism or extension of ... Antihypertensive agents. Class Summary. These agents control severe hypertension. They are recommended for patients considered ... antihypertensive agents, and antiplatelet agents. Some patients, particularly those with severe and active comorbid conditions ...
You are at: Home » Products » Pharmaceuticals and Biochemicals » Cardiovascular agentsIn total 717054 number ofProductsinfo, ...
CardiovascularThese agents inhibit platelet aggregation.Aspirin (Ecotrin, Ascriptin, Bayer Aspirin, Buffinol)Aspirin is an ... Which medications in the drug class Antiplatelet Agents, Cardiovascular are used in the treatment of Metabolic Syndrome?. ... encoded search term (Which medications in the drug class Antiplatelet Agents%2C Cardiovascular are used in the treatment of ... Cardiovascular morbidity and mortality of the metabolic syndrome. Med Clin North Am. 2007 Nov. 91(6):1169-84, x. [Medline]. ...
Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, ...
Cardiovascular agents. Class Summary. Premedication is recommended by several sources because of the risks of allergic reaction ... This agent has clearly established efficacy for analgesia and diminution of tissue damage following envenomation by Synanceia ... These agents provide local or regional anesthesia as an adjunctive or alternative pain control. ...
Hematological Agents. Each issue contains a series of timely in-depth reviews, original research articles and drug clinical ... Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry ... trial studies written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal ... and rational drug design for the discovery of new Cardiovascular & ...
... combination therapy for type 2 diabetes (RECORD): a ... The primary endpoint was cardiovascular hospitalisation or cardiovascular death, with a hazard ratio (HR) non-inferiority ... We assessed cardiovascular outcomes after addition of rosiglitazone to either metformin or sulfonylurea compared with the ... for cardiovascular death, 1.14 (0.80-1.63) for myocardial infarction, and 0.72 (0.49-1.06) for stroke. Heart failure causing ...
AgentsThese agents increase blood pressure (BP) and combat shock. Drugs in this category act primarily by increasing systemic ... Cardiovascular (Inotropic) Agents. These agents increase blood pressure (BP) and combat shock. Drugs in this category act ... encoded search term (Which medications in the drug class Cardiovascular (Inotropic) Agents are used in the treatment of Hypoxic ... Which medications in the drug class Cardiovascular (Inotropic) Agents are used in the treatment of Hypoxic-Ischemic ...
Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome (AReMIS). The safety and scientific ... Study on the Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome. ... History of coagulation and vascular disorders History of cerebrovascular accidents Cardiovascular risk factors ...
The presentation of the PLATO study showed that ticagrelor reduced the rate of cardiovascular events from 11.7 percent to 9.8 ... New oral antiplatelet agent ticagrelor first to show reduction in cardiovascular death By Professor L. C. Wallentin ... New oral antiplatelet agent ticagrelor first to show reduction in cardiovascular death. European Society of Cardiology ... In the PLATO study, the reduction in risk of cardiovascular events appears early and the benefit over clopidogrel grows with ...
This review summarizes data on the cardiovascular pharmacological actions of rutaecarpine the published over the recent years, ... Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. ... Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti- ... aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases. ...
Agent Orange ailments like cardiovascular diseases - LouB. 11/22/2016, 17:00:23 *Re: Agent Orange ailments like cardiovascular ... Agent Orange ailments like cardiovascular diseases - LEONARD 11/22/2016, 4:14:21 *Re: Agent Orange ailments like cardiovascular ... Re: Agent Orange ailments like cardiovascular diseases - LouB. 11/21/2016, 18:42:13 « Back to index , View thread » ... Agent Orange ailments like cardiovascular diseases. Posted by George Volk. on 10/26/2016, 16:52:06. 24.98.179.x. I was there in ...
Continue Learning about Cardiovascular Agent. Cardiovascular Agent Cardiovascular drugs control and treat various heart ...
Cardiovascular Risk Assessment in Patients With Severe Psoriasis Treated With Biologic Agents. This study has been completed. ... Cardiovascular Risk Assessment in Patients With Severe Psoriasis Treated With Biologic Agents. ... Investigational biological agents within 6 months prior to inclusion.. *Any other investigational drug within 1 month or 5 half ... Cardiovascular risk markers [ Time Frame: 0, 3 and 12 months ]. hs-crp, homocystein, SBHG, apolipoprotein B, MBL, PAPP-A. ...
Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry ... Cardiovascular & Hematological Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Cardiovascular & ... Cardiovascular & Hematological Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Cardiovascular & ... Cardiovascular & Hematological Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Cardiovascular & ...
Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry ... Cardiovascular & Hematological Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Cardiovascular & ... Hematological Agents was launched in 2003 and later renamed in 2006 as Cardiovascular & Hematological Agents in Medicinal ... Cardiovascular & Hematological Agents in Medicinal Chemistry , Volume 7 - Number 1. The Intermediate-Conductance Ca2+-Activated ...
Continue Learning about Cardiovascular Agent. Cardiovascular Agent Cardiovascular drugs control and treat various heart ...
Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & ... Cardiovascular & Hematological Agents in Medicinal Chemistry MEDLINE/PubMed/Index Medicus, BIOSIS Previews, BIOSIS Reviews ...
Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & ... Phytocompounds as Potential Agents to Treat Obesity-Cardiovascular Ailments Volume: 15 Issue: 2 Pp: 104-120 Balaji Meriga*, ... Cardiovascular & Hematological Agents in Medicinal Chemistry MEDLINE/PubMed/Index Medicus, BIOSIS Previews, BIOSIS Reviews ... Polypharmacy in Cardiovascular Medicine: Problems and Promises! Volume: 15 Issue: 1 Pp: 31-39 Mehran Abolbashari*, Tracy E. ...
  • This heightened awareness of potentially harmful CV effects of otherwise effective hypoglycemic drugs resulted in regulatory mandates for CV outcome trials to ascertain the safety of newer anti-hypoglycemic agents appearing on the market. (medscape.com)
  • Cardiovascular drugs control and treat various heart conditions. (sharecare.com)
  • Particular emphasis is given to insights derived from therapeutic interventions with lifestyle modification, cardiovascular drugs, antidiabetic drugs, and other related treatments. (ahajournals.org)
  • Since G protein coupled receptors (GPCRs) are target of forty percent of clinically used drugs, here we discuss the newly identified cardioprotective agents that bind GPCRs of adrenalin, adenosine, melatonin, ghrelin, galanin, apelin, prokineticin and cannabidiol. (frontiersin.org)
  • However, most of the anticancer drugs display a wide array of cardiovascular toxicities, leading to interruption of cancer therapies and maladaptive remodeling in hearts, affecting the short- and long-term quality of life ( 2 - 4 ). (frontiersin.org)
  • Use of insulin or sulfonylureas as second-line treatment in adults with type 2 diabetes is associated with increased cardiovascular risk , whereas use of newer classes of glucose-lowering drugs is not, new real-world research from the United States indicates. (medscape.com)
  • We also discuss whether other drugs in this class are likely to show similar cardiovascular benefits. (springer.com)
  • Some commonly used pesticides (for example, the organophosphate (OP) Malathion and the carbamate Sevin) and some common therapeutic drugs (the carbamates pyridostigmine [Mestinon] and physostigmine [Antilirium]) also inhibit acetylcholinesterase and can be considered 'nerve agents. (fas.org)
  • Cardiovascular drugs. (wikipedia.org)
  • Drugs acting on the cardiovascular system: Imidazo[1,2-a]pyridines: Olprinone (loprinone)-a cardiac stimulant. (wikipedia.org)
  • This second mechanism of action makes naproxcinod the first in a new class of drugs, the cyclooxygenase inhibiting nitric oxide donators (CINODs), that are hoped to produce similar analgesic efficacy to traditional NSAIDs, but with less gastrointestinal and cardiovascular side effects. (wikipedia.org)
  • Cardiovascular Drugs and Therapy. (wikipedia.org)
  • The research at Hässle led to a number of Astra drugs against cardiovascular conditions including Aptin in 1967 and Seloken in 1975. (wikipedia.org)
  • Premedication (administering sedative drugs prior this event) increases the potency of alfaxalone as an induction agent. (wikipedia.org)
  • The history of ADP inhibitors started in the year 1972 when researchers were searching for drugs similar to the anti-inflammatory agent tinoridine, a thienopyridine with anti-inflammatory and analgesic effects that had been published two years before. (wikipedia.org)
  • The new drugs thus designed achieve selective organ and/or therapeutic site drug targeting and produce safe therapeutic agents and safe environmental chemicals. (wikipedia.org)
  • One approach is the design of soft drugs (SDs), new, active therapeutic agents, often isosteric or isolelectronic analogs of a lead compound, with a chemical structure specifically designed to allow predictable metabolism into inactive metabolites after exerting their desired therapeutic effect(s). (wikipedia.org)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • The fish underwent surgery prior to the exposure to implant respiratory and cardiovascular monitoring devices, and immobilize them. (wikipedia.org)
  • By using compounds with known modes of action, these scientists could develop sets of respiratory-cardiovascular responses unique to a particular mode of action. (wikipedia.org)
  • Cardiovascular system: histamine release and blockage of the sympathetic ganglia including adrenal medulla could cause hypotension Respiratory: apnea due to phrenic blockage but bronchoconstriction can occur from the histamine release Central nervous system: no effect on intraoccular pressure Autonomic ganglion blockade can cause decrease in gut motility Duration of action prolonged in states of low potassium, calcium and protein, also in states of high magnesium and acidosis. (wikipedia.org)
  • Studies reporting an increased risk for cardiac toxicities with macrolide antibiotics have raised concern regarding their cardiovascular safety. (asm.org)
  • We sought to assess the cardiac safety of macrolide antibiotics as a class and of the individual agents by conducting a systematic review and network meta-analysis. (asm.org)
  • We hypothesized that a pulmonary exposure to AgNP induces cardiovascular toxicity influenced by inflammation and vascular dysfunction resulting in expansion of cardiac I/R Injury that is sensitive to particle size and the capping agent. (ecu.edu)
  • Exposure to both 20 and 110 nm AgNP resulted in exacerbation cardiac I/R injury 1 day following IT instillation independent of capping agent with 20 nm AgNP inducing marginally greater injury. (ecu.edu)
  • Conclusions: Exposure to AgNP may result in vascular dysfunction, a potentially maladaptive sensitization of the immune system to respond to a secondary insult (e.g., cardiac I/R) which may drive expansion of I/R injury at 1 and 7 days following IT instillation where the extent of injury could be correlated with capping agents and AgNP size. (ecu.edu)
  • Procoralan is the first pure heart rate-lowering agent and acts by selective inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarization in the sinus node and regulates heart rate. (medicalnewstoday.com)
  • Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. (wikipedia.org)
  • Class I agents are grouped by what effect they have on the Na+ channel, and what effect they have on cardiac action potentials. (wikipedia.org)
  • Dopexamine is used in hospitals as an inotropic agent to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. (wikipedia.org)
  • Since 2004 he has been conducting clinical research into antiarrhythmic agents, cardiac rhythm management devices, coronary angiography, electrophysiology, ablation procedures and imaging and mapping technologies. (wikipedia.org)
  • His research led to fundamental changes in the way cardiac arrhythmias are treated, in specific, the reduction in use of certain antiarrhythmic agents. (wikipedia.org)
  • These agents prevent seizure recurrence and terminate clinical and electrical seizure activity. (medscape.com)
  • The most extensive clinical experience has been obtained with four of these agents: verapamil, nifedipine, perhexiline, and diltiazem. (annals.org)
  • Note: The actual clinical manifestations of an exposure to a nerve agent or an organophosphate pesticide may be more variable than the syndrome described in this document. (cdc.gov)
  • Several clinical studies demonstrate that hyperleptinemia predicts acute cardiovascular events, restenosis after coronary injury such as angioplasty, and cerebral stroke independent of traditional risk factors. (ahajournals.org)
  • The following table organizes the clinical presentation of pericarditis: The classic sign of pericarditis is a friction rub heard with a stethoscope on the cardiovascular examination usually on the lower left sternal border. (wikipedia.org)
  • They are distinguished from current, clinical MR contrast agents that give only anatomical information, such as aqueous gadolinium compounds, by their ability to make molecular processes visible. (wikipedia.org)
  • A 2007 Cochrane review concluded that the quality of clinical studies is poor and there is no evidence that Dan Shen agents has any benefit for acute ischaemic stroke. (wikipedia.org)
  • most notable is its lack of cardiovascular depression at clinical doses, which makes it unique among anesthetics. (wikipedia.org)
  • The discovery program initiated by Singh initially led to the synthesis of the bis-quaternary non-depolarizing agent HS-342 (4,17a-dimethyl-4,17a-diaza-D-homo-5α-androstane dimethiodide) that was equipotent with tubocurarine and with one-third its duration of action, but not suitable for further clinical evaluation. (wikipedia.org)
  • The Marshall group then explored other modifications at the 3- and 16-positions of the androstane nucleus, but the work has not yet yielded an agent worthy of expanded evaluation to clinical testing in this azasteroidal class of neuromuscular blocking agents. (wikipedia.org)
  • Khaykin was also a member of the Arrhythmia Management Committee of the Cardiovascular Care Network, as well as the Publication Committee for the Institute for Clinical Evaluative Sciences' Implantable cardioverter-defibrillator registry, Ontario's version of the National Cardiovascular Data Registry. (wikipedia.org)
  • Both monotherapy and combination therapy with other agents was generally well tolerated in clinical trials. (wikipedia.org)
  • However, because both agents exert a negative chronotropic effect, their combined use may cause bradyarrhythmias with resultant symptoms of cerebral, coronary, and systemic hypoperfusion. (biomedsearch.com)
  • Iopamidol is primarily used in the following: Angiography throughout the cardiovascular system, including cerebral and peripheral arteriography, coronary arteriography and ventriculography, pediatric angiocardiography, selective visceral arteriography and aortography, peripheral venography (phlebography) Adult and pediatric intravenous excretory urography and intravenous adult and pediatric contrast enhancement of computed tomographic (CECT) head and body imaging Nursing Considerations: Early generations of IV contrast carried considerable nephrotoxicity, necessitating continual assessment of renal function. (wikipedia.org)
  • Previous meta-analyses assessing the cardiovascular risks of macrolides reported conflicting results ( 3 , 8 , 9 ). (asm.org)
  • FDA advisors have recommended that Pfizer be required to place a boxed warning on their non-steroidal anti-inflammatory drug Celebrex (celecoxib) for cardiovascular and gastrointestinal risks. (wikipedia.org)
  • Ultrasound contrast agents (UCAs) have been in the echocardiographic "toolbox" for many years. (onlinejacc.org)
  • However, most nondiagnostic echocardiography studies can be salvaged with ultrasound contrast agents (UCA) (1,2) . (onlinejacc.org)
  • Magnesium sulfate acts as antiarrhythmic agent and diminishes the frequency of premature ventricular contractions (PVCs), particularly those secondary to acute ischemia. (medscape.com)
  • Siddiqui's first breakthrough in research came when he successfully isolated an antiarrhythmic agent in 1931 from the roots of Rauwolfia serpentina. (wikipedia.org)
  • Flecainide acetate (/flɛˈkeɪnaɪd/ flek-AY-nyde) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart). (wikipedia.org)
  • It was formerly known as Sterling Winthrop Pharmaceuticals, whose primary product lines included diagnostic imaging agents, hormonal products, cardiovascular products, analgesics, antihistamines and muscle relaxants. (wikipedia.org)
  • Comprehensive CV risk reduction in DM should focus on aggressive management of glycemic status, blood pressure, and lipids, the use of antithrombotic agents, as well as therapeutic lifestyle modification including regular physical activities and prudent diet. (medscape.com)
  • Etomidate (USAN, INN, BAN) (marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, and cardioversion. (wikipedia.org)
  • Since their introduction in the early 1980s, CDSs have also generated considerable research work, especially for brain and eye targeting of various therapeutic agents, including those that cannot cross the blood-brain barrier or the blood-retinal barrier on their own. (wikipedia.org)
  • Derivatives of cyclo(L-His-L-Pro) have been studied extensively to develop therapeutic agents for neurodegeneration. (wikipedia.org)