Cardiovascular Abnormalities: Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Rheumatology: A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Organogold Compounds: Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.Sports: Activities or games, usually involving physical effort or skill. Reasons for engagement in sports include pleasure, competition, and/or financial reward.Athletes: Individuals who have developed skills, physical stamina and strength or participants in SPORTS or other physical activities.Sickle Cell Trait: The condition of being heterozygous for hemoglobin S.Sports Medicine: The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.Athletic Injuries: Injuries incurred during participation in competitive or non-competitive sports.Military Personnel: Persons including soldiers involved with the armed forces.American Heart Association: A voluntary organization concerned with the prevention and treatment of heart and vascular diseases.Cardiology: The study of the heart, its physiology, and its functions.Pseudotsuga: A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are coniferous evergreen trees with long, flat, spirally arranged needles that grow directly from the branch.Health Planning Councils: Organized groups serving in advisory capacities related to health planning activities.Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)Abortion, Eugenic: Abortion performed because of possible fetal defects.Syndrome: A characteristic symptom complex.ArchivesLive Birth: The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Arrhythmogenic Right Ventricular Dysplasia: A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.Isolated Noncompaction of the Ventricular Myocardium: Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.Sitosterols: A family of sterols commonly found in plants and plant oils. Alpha-, beta-, and gamma-isomers have been characterized.Hematologic Diseases: Disorders of the blood and blood forming tissues.BrazilBlood Platelet Disorders: Disorders caused by abnormalities in platelet count or function.Acacia: A plant genus of the family FABACEAE. The gums and tanning agents obtained from Acacia are called GUM ARABIC. The common name of catechu is more often used for Areca catechu (ARECA).Spain: Parliamentary democracy located between France on the northeast and Portugual on the west and bordered by the Atlantic Ocean and the Mediterranean Sea.Xanthomatosis: A condition marked by the development of widespread xanthomas, yellow tumor-like structures filled with lipid deposits. Xanthomas can be found in a variety of tissues including the SKIN; TENDONS; joints of KNEES and ELBOWS. Xanthomatosis is associated with disturbance of LIPID METABOLISM and formation of FOAM CELLS.Fontan Procedure: A procedure in which total right atrial or total caval blood flow is channeled directly into the pulmonary artery or into a small right ventricle that serves only as a conduit. The principal congenital malformations for which this operation is useful are TRICUSPID ATRESIA and single ventricle with pulmonary stenosis.Turner Syndrome: A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.Water-Electrolyte Imbalance: Disturbances in the body's WATER-ELECTROLYTE BALANCE.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)Psychoses, Alcoholic: A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Peripheral Arterial Disease: Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Judgment: The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Atrioventricular Node: A small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus. It gives rise to the atrioventricular bundle of the conduction system of the heart.Cardiovascular Physiological Phenomena: Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.Physiology: The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.Bundle of His: Small band of specialized CARDIAC MUSCLE fibers that originates in the ATRIOVENTRICULAR NODE and extends into the membranous part of the interventricular septum. The bundle of His, consisting of the left and the right bundle branches, conducts the electrical impulses to the HEART VENTRICLES in generation of MYOCARDIAL CONTRACTION.Neural Conduction: The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. (1/190)

Csx/Nkx2.5 is a vertebrate homeobox gene with a sequence homology to the Drosophila tinman, which is required for the dorsal mesoderm specification. Recently, heterozygous mutations of this gene were found to cause human congenital heart disease (Schott, J.-J., Benson, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E. and Seidman, J. G. (1998) Science 281, 108-111). To investigate the functions of Csx/Nkx2.5 in cardiac and extracardiac development in the vertebrate, we have generated and analyzed mutant mice completely null for Csx/Nkx2.5. Homozygous null embryos showed arrest of cardiac development after looping and poor development of blood vessels. Moreover, there were severe defects in vascular formation and hematopoiesis in the mutant yolk sac. Interestingly, TUNEL staining and PCNA staining showed neither enhanced apoptosis nor reduced cell proliferation in the mutant myocardium. In situ hybridization studies demonstrated that, among 20 candidate genes examined, expression of ANF, BNP, MLC2V, N-myc, MEF2C, HAND1 and Msx2 was disturbed in the mutant heart. Moreover, in the heart of adult chimeric mice generated from Csx/Nkx2.5 null ES cells, there were almost no ES cell-derived cardiac myocytes, while there were substantial contributions of Csx /Nkx2.5-deficient cells in other organs. Whole-mount &bgr;-gal staining of chimeric embryos showed that more than 20% contribution of Csx/Nkx2. 5-deficient cells in the heart arrested cardiac development. These results indicate that (1) the complete null mutation of Csx/Nkx2.5 did not abolish initial heart looping, (2) there was no enhanced apoptosis or defective cell cycle entry in Csx/Nkx2.5 null cardiac myocytes, (3) Csx/Nkx2.5 regulates expression of several essential transcription factors in the developing heart, (4) Csx/Nkx2.5 is required for later differentiation of cardiac myocytes, (5) Csx/Nkx2. 5 null cells exert dominant interfering effects on cardiac development, and (6) there were severe defects in yolk sac angiogenesis and hematopoiesis in the Csx/Nkx2.5 null embryos.  (+info)

Regression of cardiac abnormalities after replacement therapy in Addison's disease. (2/190)

OBJECTIVE: To evaluate by echocardiography the cardiac structure and function in patients with primary adrenocortical insufficiency. DESIGN AND METHODS: Two-dimensionally guided M-mode echocardiograms and spectral Doppler studies were performed in seven consecutive patients with newly diagnosed autoimmune primary adrenal failure before and 4-8 months after an adequate regimen of steroid substitution. Echocardiographic parameters were also studied in ten healthy controls. RESULTS: In the cases with untreated Addison's disease, both left ventricular end-systolic and end-diastolic dimensions were significantly reduced in comparison with those in controls (P<0.01). Four patients had echocardiographic signs of mitral valve prolapse (MVP) at the anterior leaflet, with no evidence of mitral regurgitation by Doppler echocardiography. Systolic clicks characteristic of MVP were present on auscultation in two of these cases. Left ventricular chamber size normalized, i.e. significantly increased (P<0.01), and both echocardiographic and physical signs of MVP resolved after steroid substitution in all patients. All other echocardiographic indices were normal before and after treatment. CONCLUSIONS: Patients with untreated Addison's disease have cardiac abnormalities which regress after steroid substitution. A valvular-ventricular disproportion due to the hypovolemic state could explain these findings.  (+info)

Extraembryonic venous obstructions lead to cardiovascular malformations and can be embryolethal. (3/190)

OBJECTIVE: To expand our knowledge concerning the effect of placental blood flow on human heart development, we used an embryonic chicken model in which extraembryonic blood flow was manipulated. METHODS: First, one of the three major vitelline veins was ligated, while blood flow was visualized with Indian ink. In this way, we could study the effect of different ligation positions on intracardiac flow patterns. Secondly, these vitelline veins were ligated permanently with a microclip until cardiac septation was completed, thereafter, the hearts were morphologically evaluated. In this way, we could study the impact of the ligation position on the severity and frequency of heart malformations. On combining the results, we were able to study the effect of different intracardiac flow patterns on heart development. RESULTS: Although ligation of each vein resulted in different intracardiac flow patterns, long-term ligation resulted in similar cardiovascular malformations in survivors. These consisted mainly of ventricular septum defects (VSDs), semilunar valve anomalies, and pharyngeal arch artery malformations. There was no significant difference (p > 0.05) between the ligation position and the incidence of cardiovascular malformations. However, the percentage mortality after clipping the left lateral vitelline vein was significantly higher (p < 0.05) than after ligation of either the right lateral or posterior vitelline vein. CONCLUSIONS: Early extraembryonic venous obstruction leads to altered flow patterns, which probably result in shear stress changes. In postseptation stages, these result in a spectrum of cardiovascular malformations irrespective of the ligation position. A diminished incidence of VSDs in the oldest stage was attributed to delayed closure of the interventricular foramen.  (+info)

alyron, an insertional mutation affecting early neural crest development in zebrafish. (4/190)

alyronz12 (aln) is a recessive lethal mutation that affects early stages of neural crest development in the zebrafish. alyron appears to be an insertional mutation as the mutation was generated following microinjection of plasmid DNA into one-cell embryos and the stably integrated transgenic sequences are closely linked to the mutation. The insertion site harbors multiple copies of the plasmid sequence that have experienced complex rearrangements. Host-insert junction fragments have been molecularly cloned and host sequences adjacent to the transgene have been used to map the mutation to the distal arm of linkage group 15. alyron function is required cell-autonomously in the neural crest lineage. alyron mutants have a severe but not complete deficit of premigratory neural crest as judged by reduced expression of several markers associated with early stages of neural crest development. Lack of premigratory neural crest is likely to account for the two most conspicuous characteristics of alyron mutants: the absence of body pigmentation and the inability to affect blood circulation. The neural crest phenotype of alyron mutants resembles that observed in mouse mutants that lack Pax-3 or both Wnt-1 and Wnt-3a function, and expression of the zebrafish homologues of these genes is greatly reduced in the dorsal neural keels of alyron mutants. In contrast, ventral neural keel identity appears unaffected. Given our findings that the mutation is unlinked to pax or wnt genes that have been described in the zebrafish, we propose that alyron is a novel gene function required for the specification and/or proliferative expansion of neural crest progenitors.  (+info)

Double aortic arch in a Siamese cat. (5/190)

A double aortic arch is described in an 8-week-old female Siamese cat. In this case a vascular ring anomaly consistent with a double aortic arch is described in a cat. Stridor and dysphagia were noted in the cat. Radiography showed an esophageal dilation, with constriction at the fifth intercostal space. At necropsy, the esophagus and trachea were constricted at the base of the heart. The cause of the constriction of both the esophagus and trachea was a vascular ring formed by well-developed right and left aortic arches. The ascending aorta divided into two asymmetrical arches. The right aortic arch was larger than the left. The origin of the major arteries from the aortic arches were anomalous.  (+info)

Ontogenetic aspects of hypertension development: analysis in the rat. (6/190)

In this review, we attempt to outline the age-dependent interactions of principal systems controlling the structure and function of the cardiovascular system in immature rats developing hypertension. We focus our attention on the cardiovascular effects of various pharmacological, nutritional, and behavioral interventions applied at different stages of ontogeny. Several distinct critical periods (developmental windows), in which particular stimuli affect the further development of the cardiovascular phenotype, are specified in the rat. It is evident that short-term transient treatment of genetically hypertensive rats with certain antihypertensive drugs in prepuberty and puberty (at the age of 4-10 wk) has long-term beneficial effects on further development of their cardiovascular apparatus. This juvenile critical period coincides with the period of high susceptibility to the hypertensive effects of increased salt intake. If the hypertensive process develops after this critical period (due to early antihypertensive treatment or late administration of certain hypertensive stimuli, e.g., high salt intake), blood pressure elevation, cardiovascular hypertrophy, connective tissue accumulation, and end-organ damage are considerably attenuated compared with rats developing hypertension during the juvenile critical period. As far as the role of various electrolytes in blood pressure modulation is concerned, prohypertensive effects of dietary Na+ and antihypertensive effects of dietary Ca2+ are enhanced in immature animals, whereas vascular protective and antihypertensive effects of dietary K+ are almost independent of age. At a given level of dietary electrolyte intake, the balance between dietary carbohydrate and fat intake can modify blood pressure even in rats with established hypertension, but dietary protein intake affects the blood pressure development in immature animals only. Dietary protein restriction during gestation, as well as altered mother-offspring interactions in the suckling period, might have important long-term hypertensive consequences. The critical periods (developmental windows) should be respected in the future pharmacological or gene therapy of human hypertension.  (+info)

Effects of bone marrow transplantation on the cardiovascular abnormalities in canine mucopolysaccharidosis VII. (7/190)

The genetic mucopolysaccharidoses (MPS) are a family of lysosomal storage diseases resulting from defective catabolism of glycosaminoglycans (GAGs). Echocardiographic abnormalities in dogs with MPS type VII (Sly syndrome, beta-glucuronidase deficiency) included mitral valve thickening and insufficiency, large aortic dimensions in both the long and short axes, and thickened aortic valves. Grossly, at post mortem examination, there was nodular thickening of the mitral valve, a prominent ductus diverticulum, and a dilated aorta with thickened walls. Histologically, cytoplasmic vacuolation was seen in cells of the mitral valves, coronary arteries, and aorta. By electron microscopy, the cells of the mitral valve were packed with electron-lucent cytoplasmic vacuoles. The mean residual activity of beta-glucuronidase in the aorta and myocardium was <1% of normal, the mean hexosaminidase A activity >2. 5 times normal, and the mean GAG concentrations more than twice normal. In three MPS VII dogs that received heterologous BMT at 6 weeks of age, the echocardiographic abnormalities were improved, and the histopathologic and ultrastructural pathology was reduced. In the aorta and myocardium, the mean beta-glucuronidase activity of the BMT group was 4.5% and 11% of normal, respectively, and the hexosaminidase A activity and GAG concentrations were normalized. Bone Marrow Transplantation (2000) 25, 1289-1297.  (+info)

New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. (8/190)

The Tight skin (Tsk) mutation is a duplication of the mouse fibrillin 1 (Fbn1) gene that results in a larger (418 kD) than normal (350 kD) protein; Tsk/+ mice display increased connective tissue, bone overgrowth, and lung emphysema. Lung emphysema, bone overgrowth, and vascular complications are the distinctive traits of mice with reduced Fbn1 gene expression and of Marfan syndrome (MFS) patients with heterozygous fibrillin 1 mutations. Although Tsk/+ mice produce equal amounts of the 418- and 350-kD proteins, they exhibit a relatively mild phenotype without the vascular complications that are associated with MFS patients and fibrillin 1-deficient mice. We have used genetic crosses, cell culture assays and Tsk-specific antibodies to reconcile this discrepancy and gain new insights into microfibril assembly. Mice compound heterozygous for the Tsk mutation and hypomorphic Fbn1 alleles displayed both Tsk and MFS traits. Analyses of immunoreactive fibrillin 1 microfibrils using Tsk- and species-specific antibodies revealed that the mutant cell cultures elaborate a less abundant and morphologically different meshwork than control cells. Cocultures of Tsk/Tsk fibroblasts and human WISH cells that do not assemble fibrillin 1 microfibrils, demonstrated that Tsk fibrillin 1 copolymerizes with wild-type fibrillin 1. Additionally, copolymerization of Tsk fibrillin 1 with wild-type fibrillin 1 rescues the abnormal morphology of the Tsk/Tsk aggregates. Therefore, the studies suggest that bone and lung abnormalities of Tsk/+ mice are due to copolymerization of mutant and wild-type molecules into functionally deficient microfibrils. However, vascular complications are not present in these animals because the level of functional microfibrils does not drop below the critical threshold. Indirect in vitro evidence suggests that a potential mechanism for the dominant negative effects of incorporating Tsk fibrillin 1 into microfibrils is increased proteolytic susceptibility conferred by the duplicated Tsk region.  (+info)

*Transposition of the great vessels

Ferguson EC, Krishnamurthy R, Oldham SA (2007). "Classic imaging signs of congenital cardiovascular abnormalities". ...

*Secondary hypertension

"Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease". Nature Reviews Nephrology. 5 (4): 221-28. doi: ... Because of the ubiquity of arsenic in ground water supplies and its effect on cardiovascular health, low dose arsenic poisoning ... Mackenzie IS, Rutherford D, MacDonald TM (2008). "Nitric oxide and cardiovascular effects: new insights in the role of nitric ... Pack AI, Gislason T (2009). "Obstructive sleep apnea and cardiovascular disease: a perspective and future directions". Progress ...

*Blood irradiation therapy

Originally the method was applied in the treatment of cardiovascular abnormalities. but it is now used in the treatment of a ...

*Endoglin

Experimental mice without the endoglin gene die due to cardiovascular abnormalities. In humans endoglin may be involved in the ... Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated ... "Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients". ...

*Schimmelpenning syndrome

Cardiovascular abnormalities include ventricular septal defect and co-arctation of the aorta; urinary system issues include ... The major ocular abnormalities are colobomas and choristomas. Skeletal abnormalities may include dental irregularities, ... of cases structural abnormality of cerebrum or cranium in 72% of cases The major neurological abnormalities include mental ... The abnormalities may occur in a variety of combinations, and need not include all three aspects of the classic triad of ...

*Computed tomography angiography

CT angiography began to replace conventional angiography in diagnosing and characterizing most cardiovascular abnormalities. ... "CT Angiography after 20 Years: A Transformation in Cardiovascular Disease Characterization Continues to Advance". Radiology. ...

*Larsen syndrome

... can also cause a variety of cardiovascular and orthopedic abnormalities. This rare disorder is caused by a ... Liang, C.D., Hang, C.L. " Elongation of the Aorta and Multiple Cardiovascular Abnormalities Associated with Larsen Syndrome." ... "Cardiovascular Manifestations in the Larsen Syndrome." Pediatrics. 71.6 (1983): 942-946. Print. Johnston, C.E., Birch, J.G., ... It is reasonable to believe that the joint abnormalities and cardiac anomalies associated with Larsen syndrome are related to ...

*Willis J. Potts

In addition, Potts performed the first successful repair of a cardiovascular abnormality known as a pulmonary artery sling. He ... In 1953, Potts was the first surgeon to successfully repair a pulmonary artery sling, an abnormality in which the lung blood ... The collection, which included more than 200 specimens, was later used extensively by cardiovascular pathologist Maurice Lev. ... Baffes, Thomas (July 1, 1987). "Willis J. Potts: His contributions to cardiovascular surgery". Annals of Thoracic Surgery. 44 ( ...

*Hypertrophic cardiomyopathy screening

... the incidence of Italian athlete death due to cardiovascular abnormalities. This is supported by the International Olympic ... ECGs detect heart abnormalities and detect 70% of asymptomatic HCM, but cannot diagnose that the abnormality is specifically ... If there are abnormalities, further screening by ECHO (echocardiography) is required. A study of 4,050 Italian national team ... The advantages: it is a relatively cheap and non-invasive, somewhat routine cardiovascular test that can be performed by a ...

*Nonossifying fibroma

... ocular and cardiovascular abnormalities. Fibroma Ossifying fibroma Bowers, Leah M.; Cohen, Donald M.; Bhattacharyya, Indraneel ...

*Tuberculosis radiology

... vascular abnormalities, or any other radiographically apparent cardiovascular abnormality of significant nature to require ... Musculoskeletal abnormalities - New bony fractures or radiographically apparent bony abnormalities that need follow-up. Cardiac ... Abnormalities on chest radiographs may be suggestive of, but are never diagnostic of, TB but can be used to rule out pulmonary ... Pulmonary abnormalities - Pulmonary finding of a non-TB nature, such as a mass, that needs follow-up. Other - Any other finding ...

*Christian Guilleminault

... further establishing the causative relationship between sleep apnea and cardiovascular abnormalities. Guilleminault then went ... and demonstrated reversal of cardiac arrhythmias and blood pressure abnormalities during sleep; temporarily capping these ... demonstrating its association with learning and attention problems along with cardiovascular derangements. Following this work ...

*Neosaxitoxin

NSTX produces just mild and transient cardiovascular abnormalities during experimental intoxication (there are no data on pure ... Electrophysiologic observations demonstrated sub clinical abnormalities lasting for some days or weeks after clinical recovery ... without other abnormalities. This action has been demonstrated in animals and humans. The medical use of the NSTX anesthetic ... Trends in Cardiovascular Medicine. 20 (1): 16-21. doi:10.1016/j.tcm.2010.03.002. PMC 2917343 . PMID 20685573. Templin JS, Wylie ...

*Marfan syndrome

During pregnancy, even in the absence of preconception cardiovascular abnormality, women with Marfan syndrome are at ... Prior to modern cardiovascular surgical techniques and drugs such as losartan, and metoprolol, the prognosis of those with ... Today, cardiovascular symptoms of Marfan syndrome are still the most significant issues in diagnosis and management of the ... Lifespan was reduced by at least a third, and many died in their teens and twenties due to cardiovascular problems. ...

*Fetal trimethadione syndrome

V-shaped eyebrows and a short nose Cardiovascular abnormalities Absent kidney and ureter Meningocele, a birth defect of the ... Cranial and facial abnormalities which include; microcephaly, midfacial flattening, ...

*Nuchal scan

Since chromosomal abnormalities can result in impaired cardiovascular development, a nuchal translucency scan is used as a ... to detect cardiovascular abnormalities in a fetus, though altered extracellular matrix composition and limited lymphatic ... So after this time any abnormalities causing fluid accumulation may seem to correct themselves and can thus go undetected by ... The nuchal scan helps physicians estimate the risk of the fetus having Down syndrome or other abnormalities more accurately ...

*Chronic kidney disease-mineral and bone disorder

... and calcific cardiovascular abnormalities that develop as a complication of CKD. Chronic kidney disease Renal osteodystrophy ... Abnormalities of calcium, phosphorus (phosphate), parathyroid hormone, or vitamin D metabolism Abnormalities in bone turnover, ... Therapy is generally focused on correcting biochemical and hormonal abnormalities in an effort to limit their consequences. The ... Numerous cohort studies have shown associations between disorders of mineral metabolism and fractures, cardiovascular disease, ...

*Cardiomyopathy

"Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 3: ... Practical Cardiovascular Pathology. Lippincott Williams & Wilkins. 2010. p. 148. ISBN 9781605478418. Archived from the original ... or abnormalities of the heart valves. Often, the underlying cause remains unknown, but in many cases the cause may identifiable ... both often leading to cardiovascular death or progressive heart failure-related disability. Other diseases that cause heart ...

*Marden-Walker syndrome

... cardiovascular abnormalities, hypospadias, omphalomesenteric duct, hypertriphic pyloric stenosis, duodenal bands, hyoplastic ... right lower lobe of the lung, displacement of the larynx to the right and vertebral abnormalities, cerebral malformations. 75% ...

*Coffin-Lowry syndrome

Cardio-vascular Cardiac abnormalities affect 15% of the patients. Skeleton Progressive kyphoscoliosis affects 1 in 2 patients. ... Vision and audition Auditory abnormalities are frequent and often present. Vision abnormalities are not often present. The ... cardiac abnormalities, kyphoscoliosis, as well as auditory and visual abnormalities. Coffin-Lowry syndrome is a severe mental ... retardation associated with abnormalities of: Growth In utero growth is normal but post natal growth is retarded. Patients are ...

*PDGFRB

... cardiovascular, and hematological abnormalities". Genes & Development. 8 (16): 1875-87. PMID 7958863. Darland DC, D'Amore PA ( ... Other genetic abnormalities in PDGFRB lead to various forms of potentially malignant bone marrow disorders: small deletions in ... contributes to endemic diseases such as cancer and cardiovascular disease. Human chromosome 5 deletions that remove three ...

*Turner syndrome

In the remainder, it is usually associated with cardiovascular or kidney abnormalities, including coarctation of the aorta. Two ... This abnormality is a relatively rare congenital heart disease in the general population. The prevalence of this abnormality ... Different karyotypes may have differing rates of cardiovascular malformations. Two studies found a rate of cardiovascular ... The chromosomal abnormality may be present in just some cells in which case it is known as TS with mosaicism. In these cases, ...

*Mood disorder

... thyroid abnormalities), cardiovascular disease (e.g. heart attack), pulmonary disease (e.g. chronic obstructive pulmonary ...

*G6PC3

... have a classic form of the disease with severe congenital neutropenia and cardiovascular and/or urogenital abnormalities. Some ...

*Szilard Voros

He studies cardiovascular imaging, biomarkers, lipoprotein metabolism and genomics. He is an Associate Professor of Medicine/ ... atherosclerosis and lipoprotein abnormalities. Voros and his team recently completed the ATLANTA I and ATLANTA II studies, ... He is a founding member and Fellow of the Society of Cardiovascular Computed Tomography (FSCCT), Fellow of the American College ... He previously served as the Chief Scientific Officer, Chief of Cardiovascular Prevention, and Medical Director of Cardiac MR ...

*Atrioventricular node

Abnormalities seen in BMP and Alk3 are associated with some cardiovascular diseases like Ebstein's anomaly and AV conduction ... Cardiovascular Pathology. 19 (3): e75-8. doi:10.1016/j.carpath.2008.10.011. PMID 19144541. Anatomy figure: 20:06-02 at Human ...
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TY - JOUR. T1 - Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities. T2 - Task Force 4: Congenital Heart Disease: A Scientific Statement from the American Heart Association and American College of Cardiology. AU - Van Hare, George F.. AU - Ackerman, Michael J.. AU - Evangelista, Juli Anne K. AU - Kovacs, Richard. AU - Myerburg, Robert J.. AU - Shafer, Keri M.. AU - Warnes, Carole A.. AU - Washington, Reginald L.. PY - 2015. Y1 - 2015. KW - ACC/AHA Scientific Statements. KW - athletes. KW - cardiovascular abnormalities. KW - congenital heart disease. KW - coronary vessel anomalies. KW - Fontan procedure. KW - transposition of great arteries. UR - http://www.scopus.com/inward/record.url?scp=84961055571&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84961055571&partnerID=8YFLogxK. U2 - 10.1016/j.jacc.2015.09.036. DO - 10.1016/j.jacc.2015.09.036. M3 - Article. C2 - 26542660. AN - SCOPUS:84961055571. VL - 66. SP - ...
aortic valve essay OBJECTIVE. Cardiac MDCT and cardiovascular MRI have become widely used for the evaluation of cardiovascular disease, including aortic valve disease. The purpose of this article is to present the cardiac MDCT and cardiovascular MRI findings of bicuspid aortic valve, its various complications, and other congenital cardiovascular malformations. Resume Writing Services Brisbane North! CONCLUSION. Radiologists should be aware of the clinical significance and the varied appearance of in research, bicuspid aortic valve at cardiac MDCT and cardiovascular MRI. Bicuspid aortic valve (BAV) is the most common congenital cardiovascular malformation, affecting approximately 0.5. Resume Writing Brisbane! 2% of the popu lation. BAV can coexist with other congenital cardiovascular malformations, particularly coarctation of the aorta (COA). New Cosmetologist Cover Letter! Patients with BAV are at increased risk of both valvular and vascular complications.. Serious valvular lesions include ...
The study is part of a randomized controlled trial comparing standard disease-modifying anti-rheumatic drugs (DMARDs) to anti-tumor necrosis factor (anti-TNF) therapy, Dr. Buch told Reuters Health.. "Longitudinal evaluation with repeat cardiac MRI will allow us to answer whether the abnormalities we have reported improve, whether this depends on reduction in disease activity, and whether it matters how this is achieved, i.e., DMARD versus anti-TNF. We also wish to evaluate other parameters of cardiovascular health, including exercise capacity. This work is part of a wider program of research being conducted in the Leeds CARDIO-AID group," she said.. Epidemiological studies have shown that DMARD treatment reduces the risk of cardiovascular events in RA patients, while anti-TNF treatment is associated with a greater reduction in cardiovascular event risk, Dr. Buch said. Patients with established RA who have reduced disease activity also have lower risk of cardiovascular events, she added.. "In ...
A rare syndrome combining upper limb abnormalities and congenital heart diseases. In complete syndrome there is congenital cardiovascular malformations
Cardiovascular malformations form the largest group of congenital anomalies, typically quoted at 0.8% of all live births. Several medicinal drugs have been proven to cause cardiovascular malformations. We discuss here the risks of the major known medications, including lithium, valproic acid,...
Patoma and colleagues have estimated the risk of cardiac malformations in children exposed to lithium during the first trimester of pregnancy.
Since fluoxetines release in the late 1980s, the use of antidepressants has increased steadily. Women of childbearing age make-up a significant proportion of users, so exposure during pregnancy is common. This is particularly true for early pregnancy exposure which often occurs before the woman knows she is pregnant. Estimates are that up to 13% of pregnancies will be exposed.1 The impact of these drugs on pregnancy outcomes has been a growing area of concern and debate.2 A major concern is whether the drugs are associated with congenital malformations. In their systematic review and … ...
What is the relationship between acute CNS events and cardiovascular abnormalities? CNS events can induce cardiac abnormalities in EKG morphology and rhythm. Most commonly, these abnormalities involve the T wave (diffuse, deep inversions). Minor ST segment elevation have also been reported in leads with abnormal T waves. T wave asymmetric, characteristic outward bulge in the…
Exercise is a common physiological stress used to elicit cardiovascular abnormalities not present at rest and to determine adequacy of cardiac function. Exercise ecg - one of the most frequent noninvasive modalities used to assess patients with suspected or proven cardiovascular disease. Estimate likelihood & extent of CAD , the prognosis , determine functional capacity & effects of therapy. Mainly used to estimate
Clinical trial for Heart Disease | Vascular Diseases | High Blood Pressure (Hypertension) | Cardiovascular Abnormalities | Diabetes and Hypertension , Men and Women ages 18 or older with High Blood Pressure and Diabetes Type 2 who DO NOT require the use of Insulin to control their Diabetes Levels
This classification of sports has been developed to allow a fundamental question to be addressed: whether it is reasonably safe to recommend that an athlete with a specific cardiovascular abnormality be eligible for a particular competitive sport (1,2). We recognize that cardiovascular disease assessments are imprecise and may change over time and be influenced by exercise training. Furthermore, there are potentially life-threatening aspects to the nature of the risk involved. We have attempted to incorporate these realities into the classification system.. Sports can be classified according to the type and intensity of exercise performed and also with regard to the danger of bodily injury from collision, as well as the consequences of syncope. Exercise can be divided into two broad types: dynamic (isotonic) and static (isometric) (3-6).. Dynamic exercise involves changes in muscle length and joint movement with rhythmic contractions that develop a relatively small intramuscular force; static ...
Results: Of the 38 ALL survivors, at least 1 adverse event occurred in 23 (60%), with 8 of them (21%) having multiple problems. Six (16%) of the survivors were obese and 8 (21%) of them were overweight. Subjects who were overweight or obese at the time of diagnosis were more likely to be overweight or obese at last follow-up. Obesity was more frequently determined in patients who were younger than 6 years of age at the time of diagnosis. Insulin resistance was observed in 8 (21%) subjects. Insulin resistance was more frequently seen in subjects who had family history of type 2 diabetes mellitus. Hyperlipidemia was detected in 8 (21%) patients. Hypothyroidism or premature thelarche were detected in 2 children. Two survivors had osteopenia. Cardiovascular abnormalities occurred in one of the subjects with hypertension and cardiac diastolic dysfunction ...
An initial autopsy of former Japanese finance minister Shoichi Nakagawa found cardiovascular abnormalities and alcohol in his body, but was unable to determine the cause of death, reports said on Monday.
Or you might want to embrace partners of the bridal get together. Try to include a protein source at each meal and snack throughout the day. My older sister, who also has Marfans, doesnt look proportionately unusual and, although being monitored by echocardiograms, does not present herself with the classic cardiovascular abnormalities; meaning all her cardiovascular measurements are currently within normal limits. Austrailian researchers recently discoverd that individuals who decreased fruit and vegetable consumption by 1 serving per day reported feeling rather more drained before, during, and after exercise classes. Best of all, theyre quite healthy, with anti-oxidant properties, and theyre loaded with bowl of salad nutrition like C, A, dog nutritionist nj E. 5 grams total fats per serving: Use the declaration zero grams for total fat. Moreover, in young adults, a high intact parathyroid hormone concentration was also found in Japan due to vitamin D insufficiency, duncan hines cupcakes ...
Great information by NEPAS: CURES - Cures are used in sausage products for color and flavor development as well as retarding the development of bacteria in the low temperature environment of...
CorMatrix Cardiovascular said today it won FDA 510(k) clearance for its Tyke biomaterial for use in neonates and infants.. The patch is designed to repair pericardial structures and as an epicardial covering or for intracardiac defects, septal defects, annulus repair, suture-line buttressing.. The Tyke is derived from the companys ECM technology platform and is composed of 2 layers of ECM, as opposed to 4 layers in their standard cardiac tissue repair patches, making it thinner for smaller repairs.. "FDA clearance further validates CorMatrix ECM technology for creating world class implantable cardiac devices. CorMatrix is proud of this clearance achievement and the potential impact it can have on reducing CHD in children. This is but one small step in our ongoing quest to develop and deliver ideal materials for use in reconstructing damaged cardiac and vascular tissues. Tyke and other CorMatrix cardiac products will help us extend and improve the lives of those who receive our implants and move ...
The slip ring and nutate/rotate configuration of the new, fourth-generation, computed tomography (CT) (TCT-900S, Toshiba Medical Company) makes it possible to scan consecutively 25 slices every 75 s....
WSTF兔多克隆抗体(ab50850)可与小鼠, 人样本反应并经WB, IP实验严格验证,被2篇文献引用。所有产品均提供质保服务,中国75%以上现货。
TY - JOUR. T1 - Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities. T2 - Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis: A Scientific Statement from the American Heart Association and American College of Cardiology. AU - on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology. AU - Council on Cardiovascular Disease in the Young. AU - Council on Cardiovascular and Stroke Nursing. AU - Council on Functional Genomics and Translational Biology. AU - American College of Cardiology. AU - Maron, Barry J.. AU - Udelson, James E.. AU - Bonow, Robert O.. AU - Nishimura, Rick A.. AU - Ackerman, Michael John. AU - Estes, N. A Mark. AU - Cooper, Leslie T Jr.. AU - Link, Mark S.. AU - Maron, Martin S.. PY - 2015/12/1. Y1 - 2015/12/1. KW - AHA Scientific Statements. KW - arrhythmogenic right ...
This study has shown a prevalence of cardiovascular anomalies in Downs syndrome of 42% in keeping with other published reports.8,-,10 Prevalence has remained relatively unchanged over time, although it does appear to be increasing in recent years. This may be due to improved diagnosis and the more widespread use of routine echocardiographic screening for infants with Downs syndrome.11 There has also been an increase in prenatal diagnosis of Downs syndrome,12 13 and the use of fetal echocardiography.14 15. The North East of England is well suited for population-based studies as it encompasses a well-defined geographical area with little cross-referral, reducing the risks of ascertainment bias. Data from our region have previously shown an increase in the prevalence of pregnancies affected by Downs syndrome and that, contrary to previous predictions, the prevalence of live born Downs syndrome has remained static, with a live birth prevalence of around 1.09 per 1000 live births.4 These babies ...
Chromosome 22q11.2 heterozygous deletions cause the most common deletion syndrome, including the DiGeorge syndrome phenotype. Using a mouse model of this deletion (named Df1) we show that the aortic arch patterning defects that occur in heterozygously deleted mice (Df1/+) are associated with a differentiation impairment of vascular smooth muscle in the 4th pharyngeal arch arteries (PAAs) during early embryogenesis. Using molecular markers for neural crest, endothelial cells and vascular smooth muscle, we show that cardiac neural crest migration into the 4th arch and initial formation of the 4th PAAs are apparently normal in Df1/+ embryos, but affected vessels are growth-impaired and do not acquire vascular smooth muscle. As in humans, not all deleted mice present with cardiovascular defects at birth. However, we found, unexpectedly, that all Df1/+ embryos have abnormally small 4th PAAs during early embryogenesis. Many embryos later overcome this early defect, coincident with the appearance of ...
Douglas P. Zipes, Mark S. Link, Michael J. Ackerman, Richard J. Kovacs, Robert J. Myerburg, N.A. Mark Estes and on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, and the American College of Cardiology ...
Double aortic arch is a relatively rare congenital cardiovascular malformation. Double aortic arch is an anomaly of the aortic arch in which two aortic arches form a complete vascular ring that can compress the trachea and/or esophagus. Embryologically, the aortas right sided 4th arch failed to r...
Background-Bicuspid aortic valve (BAV) is the most common congenital cardiovascular malformation (CVM). Although highly heritable, few causal variants have been identified. The purpose of this study was to identify genetic variants underlying BAV by whole exome sequencing (WES) a multiplex BAV kindred. Methods and Results-WES was performed on 17 individuals from a single family (BAV = 3, other CVM = 3). Post variant calling error control metrics (ECM) were established after examining the relationship between Mendelian inheritance error rate and coverage, quality score, and call rate. To determine the most effective approach to identifying susceptibility variants from among 54,674 variants passing ECM, we evaluated three variant selection strategies frequently used in WES studies plus extended family linkage. No putative rare, high impact variants were identified in all affected but no unaffected individuals. Eight high impact variants were identified by at least two of the commonly used ...
To the Editor: Williams-Beuren Syndrome (WBS) is a rare neurodevelopmental disorder caused by deletion of chromosome 7 at q11.23. It is characterized by distinctive facies, congenital cardiovascular malformations, intellectual ...
To the Editor: Williams-Beuren Syndrome (WBS) is a rare neurodevelopmental disorder caused by deletion of chromosome 7 at q11.23. It is characterized by distinctive facies, congenital cardiovascular malformations, intellectual ...
Barium swallow reveals fixed narrowing of the oesophagus at the level of the aortic arch without mucosal abnormality. The narrowing runs oblique from inferior left to superior right and involves the posterior aspect of the oesophagus. This is c...
In lecture 7 - Early Vascular Development, there was an introduction to the origins of the cardiovascular system. This second lecture will now focus on the extensive remodeling that occurs in both the heart and vascular system during later development. In addition, there will be discussion on the major cardiovascular abnormalities. The laboratory this week will also give you the opportunity to work through some of these concepts using a new online teaching module. ...
Exercise is a common physiology stress used to elicit cardiovascular abnormalities not present at rest and to determine the adequacy of cardiac function. Tread Mill Test (TMT) is one of the most frequent non invasive modalities used to assess patients with suspected or proven CAD. The test is mainly used to estimate prognosis and to determine functional capacity, the likelihood and extent of CAD, and the effects of therapy. The treadmill protocol should be consistent with the patients physical capacity and the purpose of the test. The Bruce multistage maximal treadmill protocol has 3-minute periods to allow achievement of a steady state before work-load is increased. In older individuals or those whose exercise capacity is limited by Cardiac Disease, the protocol can be modified by two 3-minute warm-up stages. The sensitivity of the Tread Mill Test (TMT) in patients with CAD is approximately 68%, and specificity is 77%. The exercise electrocardiography (ECG) result is more likely to be abnormal ...
Intake of garlic has been reported earlier to reduce blood pressure and improve cardiovascular abnormalities, and many studies thereafter explored the cardioprotective properties of garlic[11, 12]. These new findings resulted in an increase in demand for garlic products in the market and encouraged the development of wide varieties of garlic with better quality and which would be grown more efficiently. In this study, we used extracts from a variety of hard necked Rocambole purple garlic developed locally in Manitoba, Canada. This new garlic variety is better adapted to harsh climate and has superior disease resistance qualities. In general, the purple garlic has a colored skin which possibly indicates the presence of a different set of bioactive compounds when compared to the normal variety of garlic with white skin. Furthermore, no study has explored the medicinal properties of garlic skin in any form. Accordingly, in this study we used skin and flesh extracts from a purple variety of garlic ...
(HealthDay) -- Regardless of exposure to cardiotoxic cancer therapies, survivors of childhood cancers display cardiovascular abnormalities and have markers of increased systemic inflammation and atherosclerotic disease, according ...
Aberrant right subclavian artery (ARSA), also called "lusorian artery", is a well known anatomical variant of the origin of the right subclavian artery, one of the most common congenital vascular abnormalities of the aortic arch (the prevalence among the population is 1-2% in according to different authors) [1-4]. Usually ARSA arises after the left subclavian artery and crosses the mediastinum behind the oesophagus and the trachea. For its particular position ARSA can cause compression to the close anatomical structures. Dysphagia lusoria is the most frequent symptom (in 10 % of cases). For the same reason the prolonged compression caused by medical devices such as nasogastric or endotracheal tubes on the arterial wall of the ARSA can cause severe injury, especially when an ARSA aneurysm is present. In rare cases it can lead up to an oesophageal fistula with profuse bleeding characterised by high mortality rate (till now less than 20 cases were reported in literature). In our case fistulisation ...
homeostasis, and disease. Cell. 2009 Apr 3;137(1):32-45.. Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Dev Cell. 2007 Nov;13(5):609-22.. Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec;129(24):5827-38.. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol. 2008 Sep;9(9):690-701.. Henderson DJ, Conway SJ, Greene ND, Gerrelli D, Murdoch JN, Anderson RH, Copp AJ. Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant. Circ Res. 2001 Jul 6;89(1):6-12.. Henderson DJ, Anderson RH. The development and structure of the ventricles in the human heart. Pediatr Cardiol. 2009 Jul;30(5):588-96.. Hildreth V, Webb S, Chaudhry B, Peat JD, Phillips HM, Brown N, ...
Coarctation of the aorta is a common congenital cardiovascular defect characterized by upper-body hypertension resulting from constriction of the aorta. Constrictions vary in degree; they may occur at any point from the transverse arch to the iliac bifurcation.
There is currently a deficiency in understanding the events that effect proper cardiovascular development. The long-term goal is to define these events in molec...
INTRODUCTION: Floating thrombus in an aberrant right subclavian artery is a rare cause of peripheral arterial embolic events. CASE REPORT: We report a 45-year-old woman who presented with an ischemia of the right superior limb from embolic event. The diagnosis of mobile thrombus in an aberrant right subclavian artery was obtained with transoesophageal echocardiography and computed tomography. After three weeks of oral anticoagulant therapy, there was no significant resolution of the thrombus, and a surgical treatment was performed to prevent further embolization. The surgical procedure consisted of thrombectomy and reimplantation of the aberrant right subclavian artery to the right carotid artery. Postoperative recovery was uneventful. CONCLUSION: This case report illustrates that transoesophageal echography and computed tomography are useful to detect mobile thrombus of the thoracic aorta and is warranted in any embolic event in young patients.
Details of the image Dysphagia lusoria from aberrant left subclavian artery with Kommerell diverticulum Modality: Fluoroscopy (Frontal)
A two-year-old Border Collie presented with a three-month history of regurgitation. Investigation with plain radiography, digital fluoroscopy, endoscopy and CT angiography (CTA) confirmed the presence of an aberrant right subclavian artery causing dorsal oesophageal compression. In this report, CTA was used to depict the anatomy of an aberrant right subclavian vessel and to highlight the importance of this imaging modality to identify the structures involved in a vascular ring. This report also identifies a patient with a congenital vascular ring anomaly presenting with adult-onset regurgitation, which has been successfully managed with medical treatment. ...
BAV is one of the most common congenital cardiovascular malformations, with an estimated incidence of 1% to 2%.25 An echocardiographic survey of primary school children demonstrated a BAV prevalence of 0.75% in males and 0.24% in females.26 The true prevalence of BAV in newborns was determined in a recent study of 1075 neonates screened by echocardiography.27 BAV was identified in a prevalence of 4.6 per 1000 live births. The prevalence of BAV by sex was 7.1/1000 in male neonates and 1.9/1000 in female neonates. BAV is sometimes inherited, and family clusters have been studied. Inheritance patterns are autosomal dominant with variable penetrance.28,29 Prevalence among asymptomatic family members of patients with BAV was 37% by echocardiographic screening. First-degree relatives of patients with various types of LVOTO are at an increased risk of having BAV compared with the general population.30. BAVs arise from abnormal valvulogenesis and cusp formation, resulting in the formation of 1 smaller ...
Deletion of the transcriptional modulator Cited2 in the mouse results in embryonic lethality, cardiovascular malformations, adrenal agenesis, cranial ganglia fusion, exencephaly, and left-right patterning defects, all seen with a varying degree of penetrance. The phenotypic heterogeneity, observed on different genetic backgrounds, indicates the existence of both genetic and environmental modifiers. Mice lacking the LIM domain-containing protein Lmo4 share specific phenotypes with Cited2 null embryos, such as embryonic lethality, cranial ganglia fusion, and exencephaly. These shared phenotypes suggested that Lmo4 may be a potential genetic modifier of the Cited2 phenotype. Examination of Lmo4-deficient embryos revealed partially penetrant cardiovascular malformations and hypoplastic thymus. Examination of Lmo4;Cited2 compound mutants indicated that there is a genetic interaction between Cited2 and Lmo4 in control of thymus development. Our data suggest that this may occur, in part, through control of
The American Heart Association (AHA) and American College of Cardiology (ACC) have provided recommendations regarding eligibility and disqualification of competitive athletes with cardiovascular abnormalities.
It is suggested to measure PVi in the same body position, remaining still and without talking, at the same breathing rate and depth of breathing, until you see a high confidence PVi value (displayed value is bright, not dim). An increase in PVi may indicate a decreased level of hydration, increased breathing effort, or other factors. A decrease in PVi may indicate an increased level of hydration, decreased breathing effort, or other factors. Multiple factors other than hydration and breathing effort can affect PVi, including breathing rate, depth of breathing, body position, body movement, vascular tone, blood flow to the finger (perfusion index), normal variation within a short-term monitoring session, waveform shape changes, and/or cardiovascular abnormalities. ...
Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for lactic acidosis. Advanced age and cardiovascular and renal disease are absolute contraindications to the use of phenformin in diabetics. ...
Dysphagia lusoria is a well documented complication of variant aortic arch anatomy. Typically it is associated with an aberrant right subclavian artery causing dysphagia by compression. The word lusoria originates from the Latin origin lusus naturae, meaning freak of nature. Dysphagia as a result of tortuous and ectatic anatomy of the carotid vessels is rare. We have identified a few similar cases, including one from 2010 1, which describes a medially coursing left internal carotid artery resulting in difficulty swallowing. It appears that dysphagia, as a result of common carotid ectasia is even rarer, with only a couple of cases appearing in literature2 ...
TY - JOUR. T1 - Loss of function of the Prx1 and Prx2 hameobox genes alters architecture of the great elastic arteries and ductus arteriosus. AU - Bergwerff, Maarten. AU - Gittenberger-de Groot, Adriana C.. AU - Wisse, Lambertus J.. AU - DeRuiter, Marco C.. AU - Wessels, Andy. AU - Martin, James F.. AU - Olson, Eric N.. AU - Kern, Michael J.. PY - 2000. Y1 - 2000. N2 - Prx1 (MHox) and Prx2 (S8) are non-clustered homeobox genes that are expressed in a complex, mostly mesenchyme-specific pattern throughout embryogenesis. The expression pattern and gene-targeted mice previously revealed a major role for Prx1 in skeletogenesis. In addition, specific and high expression of both Prx genes was reported in the developing cardiovascular system, predominantly in prospective connective tissues of the heart and in the great arteries and veins. We examined embryos of previously generated gene-targeted mice. Prx2-/- mutants were viable and did not show cardiovascular malformations. Intracardiac morphology of ...
Searching through the biomedical literature, I looked at four major categories of caffeine effects on the developing fetus. The first category, major birth defects, was easy to evaluate. Very high levels of caffeine have been shown to cause birth defects in animals (Nehlig & Debry 1994), but the levels at which these effects are seen are so high that they would not practically apply to even staunchly caffeine-addicted humans. To assess whether caffeine has these kinds of effects in humans, epidemiological studies (studies of populations of humans) must be used. In a systematic review of the epidemiological literature on cardiovascular malformations and oral clefts (Browne 2006), no evidence was found that caffeine alone was teratogenic for humans. [Caffeine has, however, been found to increase the risk of birth defects by other substances, such as tobacco and alcohol (Nehlig & Debry 1994)]. In a review of several animal studies and epidemiological studies exploring birth defects in general, ...
The formation and transformation of the pharyngeal arch arteries in the mouse embryo, from 8.5 to 13 days of gestation (DG), was observed using scanning electron microscopy of vascular casts and graphic reconstruction of 1-microm serial epoxy-resin sections. Late in 8.5-9DG (12 somites), the paired …
a Four branches arises from the aortic arch. Aberrant right subclavian artery(ARSA) marked by astrex. b ARSA arises distal to left subclavian artery. c Obstruct
CT examination of the chest with IV contrast performed accoring to a PE/DVT protocol demonstrated an aberrant right subclavian artery. The mediastinum was othe
The use of amphetamines is associated with an increase in cardiovascular defects in babies. Barbiturate use during pregnancy may be linked to birth defects, withdrawals, poor feeding, and seizures. Opiods are associated with abnormalities and complications during pregnancy.
The use of amphetamines is associated with an increase in cardiovascular defects in babies. Barbiturate use during pregnancy may be linked to birth defects, withdrawals, poor feeding, and seizures. Opiods are associated with abnormalities and complications during pregnancy.
Learn about the causes, symptoms, diagnosis & treatment of Congenital Cardiovascular Anomalies from the Professional Version of the Merck Manuals.
Small molecule microribonucleic acids (miRNAs) are coming up with a huge impact on the scientific world of therapeutics and diagnostics
On January 10, 2011 my son, Noah, passed away from complications related to Heterotaxy Syndrome. He was just 32 days old. Life has been pretty rough for me and my husband since then. Counselors, spiritual leaders and other bereaved parents advised us that losing a child is one of the worst things a person can…
Reconstruction of the endocardium of the heart and its arterial trunks in No. 6520, a member of the median third of stage 17. It is shown in two parts, A and B. In A, only the derivatives of the primary cardiac tube are shown. In B, enough of the primary tube is removed to expose the venous part of the heart. The latter, being in a contracted state, reveals in an unobstructed view the right and left atrioventricular canals, now clearly separated, each leading forward into its respective ventricle. It will be noted that the primary cardiac tube is connected with the venous part of the heart only at the two atrioventricular junctions. When the latter are severed, the arterial portion can be freely separated from the venous part. In A, the cleavage has not yet crossed the crest of the septum, and both arterial trunks lead off from both ventricles. From the distention of the endocardium of the primary cardiac tube, however, one can see that the left ventricle favors the aorta and the right ventricle ...
Unilateral pulmonary artery agenesis is a rare congenital anomaly often associated with other cardiovascular abnormalities. It is usually diagnosed and surgically treated in childhood. Subjects without associated cardiac anomalies (isolated unilatera
BACKGROUND:. Cardiovascular abnormalities have been reported in Acquired Immunodeficiency Syndrome (AIDS) clinically, echocardiographically and at autopsy. Pericardial effusion, cardiac tamponade, echocardiographic abnormalities and clinical cardiomyopathy with right and left-sided congestive heart failure have all been reported as isolated case reports or in small retrospective series of patients with AIDS who had echocardiograms. The frequency with which abnormalities specifically related to AIDS were found in consecutively studied patients was not known in 1988 when the study began.. The etiology of these abnormalities was also unclear. Since HIV infection resulted in profound suppression of T-cell macrophage-mediated immunity in AIDS and since there were significant abnormalities in B-cell lymphocyte function resulting in abnormalities of humoral immunity, there were frequently life threatening superinfections by bacterial, fungal, parasitic, and viral organisms. Some of these, such as ...
BACKGROUND:. Cardiovascular abnormalities have been reported in Acquired Immunodeficiency Syndrome (AIDS) clinically, echocardiographically and at autopsy. Pericardial effusion, cardiac tamponade, echocardiographic abnormalities and clinical cardiomyopathy with right and left-sided congestive heart failure have all been reported as isolated case reports or in small retrospective series of patients with AIDS who had echocardiograms. The frequency with which abnormalities specifically related to AIDS were found in consecutively studied patients was not known in 1988 when the study began.. The etiology of these abnormalities was also unclear. Since HIV infection resulted in profound suppression of T-cell macrophage-mediated immunity in AIDS and since there were significant abnormalities in B-cell lymphocyte function resulting in abnormalities of humoral immunity, there were frequently life threatening superinfections by bacterial, fungal, parasitic, and viral organisms. Some of these, such as ...
Willis John Potts (March 22, 1895 - May 5, 1968) was an American pediatric surgeon and one of the earliest physicians to focus on the surgical treatment of heart problems in children. Potts set up one of the countrys early pediatric surgery programs at Childrens Memorial Hospital in Chicago. A graduate of the University of Chicago and Rush Medical College, Potts was known for introducing a surgery to address the heart defects that resulted in blue baby syndrome; the procedure became known as the Potts shunt. In addition, Potts performed the first successful repair of a cardiovascular abnormality known as a pulmonary artery sling. He also invented several surgical instruments, with a particular emphasis on devices that allowed for safe surgery on major blood vessels. Potts remained a surgeon at Childrens Memorial Hospital and a faculty member at the Northwestern University Medical School well into the 1960s. He retired to Sarasota, Florida, where he died of a heart attack in 1968. Born in 1895 ...
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this ...
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this ...
The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numerous cardiovascular abnormalities, including myocardial infarction, hypertension, thrombosis and atherosclerosis. Genomic sequencing has discovered several genetic variations in the PTGIR gene coding for hIP receptor, however, its structure-function relationship has not been sufficiently explored. Here we set out to investigate the applicability of high throughput random mutagenesis to study the structure-function relationship of hIP receptor. While chemical mutagenesis was not suitable to generate a mutagenesis library with sufficient coverage, our data demonstrate error-prone PCR (epPCR) mediated mutagenesis as a valuable method for the unbiased screening of residues regulating hIP receptor function and expression. Here we describe the generation and ...
During the last half-century, numerous antiinflammatory agents were tested in dozens of clinical trials and have proven ineffective for treating septic shock. The observation in multiple studies that cell-free hemoglobin (CFH) levels are elevated during clinical sepsis and that the degree of increase correlates with higher mortality suggests an alternative approach. Human haptoglobin binds CFH with high affinity and, therefore, can potentially reduce iron availability and oxidative activity. CFH levels are elevated over approximately 24-48 hours in our antibiotic-treated canine model of S. aureus pneumonia that simulates the cardiovascular abnormalities of human septic shock. In this 96-hour model, resuscitative treatments, mechanical ventilation, sedation, and continuous care are translatable to management in human intensive care units. We found, in this S. aureus pneumonia model inducing septic shock, that commercial human haptoglobin concentrate infusions over 48-hours bind canine CFH, ...
Aberrant right subclavian artery (ARSA) or arteria lusoria is one of the most common congenital aortic arch anomaly with prevalence ranging from 1-2%. However, it is mostly asymptomatic and consequently often found sporadically during various diagnostic procedures with prevalence of 0.45% during coronary angiography.
Synonyms for arteria lusoria in Free Thesaurus. Antonyms for arteria lusoria. 2 synonyms for arteria: arterial blood vessel, artery. What are synonyms for arteria lusoria?
Cardiovascular malformation is the most common group of congenital malformations. The prevalence at live birth diagnosed in infancy in this study was 5.3 cases per 1000 live births. This is consistent with previous large studies using similar methodology.10-12Our register of live born congenital heart disease was set up in 1990 with prospective ascertainment of all cases since then but retrospective ascertainment of cases in 1987-9. We are confident of complete ascertainment of all cases of complex or clinically significant heart disease throughout this study, but there was probably some under ascertainment of minor heart disease in 1987-1989. Recent prospective studies, with ready availability of early echocardiographic examination, have shown a higher of prevalence of live born heart disease, almost all of which is accounted for by the detection of more small ventricular septal defects.13-15 Early recognition of congenital heart disease is important because clinical presentation and ...
This is 3d model of aortic arch with bicarotid trunk anomaly and aberrant right subclavian artery (arteria lusoria), which was made from CTA scan. The patient is caucasian woman with stenosis of the left vertebral artery (which is not included) and severe disphagia. Its part of a anatomical serie...
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The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional. ...
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Q: What is DiGeorge syndrome?A: DiGeorge syndrome (DGS) is a genetic disorder caused by the deletion of some of the genes on chromosome 22. There is a lot of variability in how patients are affected by this syndrome, with the manifestations in an individual person depending on exactly which genes are deleted.DGS affects about one in every 5,000 babies. Although DGS may be inherited (in a dominant fashion, so if either parent has it there is a 50 percent chance the child will inherit it), over
Q: What is DiGeorge syndrome?A: DiGeorge syndrome (DGS) is a genetic disorder caused by the deletion of some of the genes on chromosome 22. There is a lot of variability in how patients are affected by this syndrome, with the manifestations in an individual person depending on exactly which genes are deleted.DGS affects about one in every 5,000 babies. Although DGS may be inherited (in a dominant fashion, so if either parent has it there is a 50 percent chance the child will inherit it), over
Q: What is DiGeorge syndrome?A: DiGeorge syndrome (DGS) is a genetic disorder caused by the deletion of some of the genes on chromosome 22. There is a lot of variability in how patients are affected by this syndrome, with the manifestations in an individual person depending on exactly which genes are deleted.DGS affects about one in every 5,000 babies. Although DGS may be inherited (in a dominant fashion, so if either parent has it there is a 50 percent chance the child will inherit it), over
Q: What is DiGeorge syndrome?A: DiGeorge syndrome (DGS) is a genetic disorder caused by the deletion of some of the genes on chromosome 22. There is a lot of variability in how patients are affected by this syndrome, with the manifestations in an individual person depending on exactly which genes are deleted.DGS affects about one in every 5,000 babies. Although DGS may be inherited (in a dominant fashion, so if either parent has it there is a 50 percent chance the child will inherit it), over
A nuchal scan or nuchal translucency (NT) scan/procedure is a sonographic prenatal screening scan (ultrasound) to detect cardiovascular abnormalities in a fetus, though altered extracellular matrix composition and limited lymphatic drainage can also be detected. Since chromosomal abnormalities can result in impaired cardiovascular development, a nuchal translucency scan is used as a screening, rather than diagnostic, tool for conditions such as Down syndrome, and non-chromosomal abnormalities, including the genetic Di George syndrome and non-genetic Body-stalk anomaly. The scan is carried out at 11-13+6 weeks pregnancy and assesses the quantity of fluid collecting within the nape of the fetal neck. There are two distinct measurements - the nuchal translucency, which is measured earlier in pregnancy at the end of the first trimester, and for which there is a lower threshold for increased diameter, and the nuchal fold, which is measured towards the end of the second trimester. The scan may also ...
video clip.. With an estimated human population prevalence of 1:2000, Velo-Cardio-Facial Syndrome (VCFS) is the second-most common multiple anomaly syndrome in humans and almost all children with the syndrome have speech and language impairments that are generally recognized to be complex and difficult to treat.. To demonstrate and to provide clinicians with expert guidance, the authors have produced a comprehensive two-volume set with a combination of text and video demonstrating the clinical features of Velo-Cardio-Facial Syndrome (VCFS); the communication phenotype in VCFS; the natural history of speech and language in VCFS; diagnostic procedures necessary for assessing speech and language disorders in VCFS; the treatment of speech and language impairment in VCFS; and outcomes, demonstrated by video on an accompanying DVD to Volume II.. This volume commences with a survey of the history of VCFS and provides an exhaustive description of the 190 phenotypes associated with the syndrome, ...
Mutation analysis of our cohort of non-deleted patients did not detect any cases with unambiguous loss of TBX1 function. Considering the strong experimental evidence for a major role of TBX1 in the 22q11 deletion syndrome from the deletion studies in the mouse,14-16 our findings are somewhat surprising. In contrast to our results, the majority of mutations inTBX5 in association with Holt-Oram syndrome are predicted to produce haploinsufficiency by nonsense or frameshift mutations within the T box region.12 13 23 Similarly, five of the 10 published mutations in TBX3, found in patients with ulnar-mammary syndrome, are predicted to disrupt the DNA binding domain.24 It is likely that the aetiology of non-deleted DGS/VCFS patients is heterogeneous. Malformations similar to those seen in the 22q11 deletion syndrome have been associated with prenatal exposure to retinoic acids and ethanol, maternal diabetes, and deletions of the short arm of chromosome 10. Therefore, it is possible that mutations ...
Common arterial trunk (CAT) is a relatively rare congenital heart malformation with an incidence of approximately 0.07 per 1000 live births (approximately 0.7% of congenital heart diseases). This low incidence as compared to other congenital malformations may underlie the fact that only few courses have been attributed specifically to CAT. Nevertheless, in dealing with patients with CAT a myriad of anatomical considerations are involved, including variations in truncal valve anatomy, coronary arteries, pulmonary arteries, and associated anomalies, that all have their impact on surgical interventions and (late) clinical outcome. This dedicated course aims to provide insight in the three dimensional morphology of CAT in the full spectrum from prenatal development to long term follow up. The extensive Leiden Collection of post-mortem specimens with congenital heart disease provides the possibility to study this cardiac malformation in hands-on sessions.. A panel of cardiac surgeons, paediatric ...
A premature neonate with gestational age of 32 weeks and birth body weight of 1650 grams was diagnosed to have type A interrupted aortic arch, perimembranous type ventricular septal defect, atrial septal defect, and patent ductus arteriosus. One-stage complete reconstruction of aortic arch and concomitant repair of intracardiac defects was performed at age of 13 days with body weight of 1600 grams. Through innominant artery and retrocardiac descending aorta cannulation for continuous cerebral and lower body perfusion, deep hypothermic circulatory arrest was avoided. Postoperative renal function was excellent, and there were no neurological sequelae after 24 months follow-up.
Observations in this study provide additional evidence for a role of NKX2.5 beyond early cardiac progenitor commitment; the coinheritance of heterozygous NKX2.5 mutations with various congenital heart defects suggests that this transcription factor contributes to diverse cardiac developmental pathways including atrial, ventricular, and conotruncal septation, AV conduction, and AV valve formation. As described previously, AV block and ASD are common in kindreds in whom congenital heart disease is due to NKX2.5 mutation (19). Additionally, NKX2.5 mutation causes AV block without associated congenital heart defects, and, as demonstrated in the patients we studied, AV block was the principal clinical finding in 23% of genotype-positive individuals. Further, based on results of the present study, NKX2.5 mutation may account for a clinically significant portion of idiopathic AV block.. However, cardiovascular defects resulting from NKX2.5 mutations extend beyond AV block and ASD. For example, VSD was ...
TY - JOUR. T1 - Isolation and characterization of a novel gene deleted in digeorge syndrome. AU - Kurahashi, Hiroki. AU - Akagi, Kenzo. AU - Inazawa, Johji. AU - Ohta, Tohru. AU - Niikawa, Norio. AU - Kayatani, Futoshi. AU - Sano, Tetsuya. AU - Okada, Shintaro. AU - Nishisho, Isamu. PY - 1995/4/1. Y1 - 1995/4/1. N2 - The region commonly deleted in DiGeorge syndrome (DGS) has been localized at 22q11.1-q11.2 with the aid of a high resolution banding technique. A 22q11 specific plasmid library was constructed with a microdissection and microcloning method. Dosage analysis proved three of 144 randomly selected microclones to detect hemizygosity in two patients with DGS. Two of the clones were found to contain independent low-copy-number repetitive sequences, all of which were included in the region deleted in the DGS patients. Screening of the cosmid library and subsequent cosmid walking allowed us to obtain two cosmid contigs corresponding to the microclones within the deletion (contig 1 and contig ...
Case Summary The patient was a 7-year-old female who presented to the emergency department with a one-day history of abdominal pain and emesis. Her medical h...
Genetic differences between people with chromosomal deletion, 22q11.2, or DiGeorge syndrome, who have autism and those with psychosis
Back in August, 2009 Charlotte went for her periodic check up with her cardiologist Dr. Young. At the time, Dr. Young was unable to get a clear picture of Charlottes right pulmonary artery. Since this is the arterial trunk that had constriction leading to her second surgery and had a special surgical procedure done to…
Abstract: An unusual vascular ring anomaly consisting of a persistent right aortic arch and a left ligamentum arteriosum extending from the main pulmonary artery to an aberrant left subclavian artery and left aortic arch remnant complex was identified in a German shepherd dog and a great Dane. The left subclavian artery and left aortic arch remnant complex originated at the junction between the right distal aortic arch and the descending aorta and coursed dorsal to the oesophagus in a cranial direction. The attachment of the ligamentum arteriosum to the aberrant left subclavian artery was approximately 5 cm cranial to the point of origin of the aberrant left subclavian artery and left aortic arch remnant complex from the descending aorta in both dogs. This anomaly observed in both dogs is similar to an anomaly reported in humans, in which a persistent right aortic arch is found in conjunction with an aberrant left subclavian artery and a left aortic arch remnant (Kommerells diverticulum). ...
The prevalence rate for cardiovascular malformations in dogs presented to a large university veterinary clinic was 6.8 per 1000. Patent ductus arteriosus, as in man, was found predominantly in females. Breed-specific prevalence rates were significantly greater in purebred dogs than in mongrels, and the breed distributions of patent ductus arteriosus, pulmonic stenosis, subaortic stenosis, persistent right aortic arch, and tetralogy of Fallot were significantly different than would be expected if all breeds were equally susceptible to each type of malformation. On the basis of these observations, two hypotheses were made: (1) Genetic factors are determinants of certain types of congenital heart disease in the dog. (2) These genetic factors have specific effects on cardiac morphogenesis, resulting in specific types of cardiovascular malformations. Preliminary genetic studies confirmed the specific hereditary transmission of valvular pulmonic stenosis in beagles, persistent right aortic arch in ...
Aortic valve calcification (AVC) without outflow obstruction (stenosis) is common in the elderly and increases the risk of cardiovascular morbidity and mortality. Although high blood pressure (BP) measured at the doctors office is known to be associated with AVC, little is known about the association between 24-hour ambulatory BP (ABP) and AVC. Our objective was to clarify the association between ABP variables and AVC. The study population consisted of 737 patients (mean age, 71±9 years) participating in the Cardiovascular Abnormalities and Brain Lesions study who underwent 24-hour ABP monitoring. Each aortic valve leaflet was graded on a scale of 0 (normal) to 3 (severe calcification). A total valve score (values 0-9) was calculated as the sum of all leaflet scores. Advanced AVC (score ≥4) was present in 77 subjects (10.4%). All of the systolic ABP variables (except systolic BP nocturnal decline) and mean asleep diastolic BP were positively associated with advanced calcification, whereas normal
Murine should not be used if there is an eye condition characterised by continued redness, pain or blurring of vision.. Murine should not be used if there is raised pressure inside the eyeball (glaucoma), damage to the corneas, inflammation of the iris (acute iritis) or any other serious eye disease.. If there is any eye pain, vision changes, continued redness or irritation of the eye, or if the condition worsens or persists for more than 24 hours, use of the product should be discontinued and the doctor or pharmacist should be informed.. Discontinue use prior to use of anaesthetics which sensitise the myocardium to sympathomimetics (e.g. cyclopropane, halothane).. As with other sympathomimetics, use with caution in the presence of hypertension, diabetes, hyperthyroidism, cardiovascular abnormalities and arteriosclerosis.. Contains benzalkonium chloride which may cause eye irritation. Avoid contact with soft contact lenses; remove contact lenses prior to application and wait at least 15 minutes ...
The pediatric experts at the Nemours Cardiac Center diagnose and treat children with heterotaxy syndrome affecting the heart at the Nemours/Alfred I. duPont Hospital for Children in Wilmington, Del.
Cardiac development in vertebrates is a finely tuned process regulated by a set of conserved signaling pathways. Perturbations of these processes are often associated with congenital cardiac malformations. Platelet-derived growth factor receptor α (PDGFRα) is a highly conserved tyrosine kinase receptor, which is essential for development and organogenesis. Disruption of Pdgfrα function in murine models are embryonic lethal due to severe cardiovascular defects, suggesting a role in cardiac development, thus necessitating the use of alternative models to explore its precise function. In this study, we generated a zebrafish pdgfra mutant line by gene trapping, in which the Pdgfra protein is truncated and fused with mRFP (Pdgfra-mRFP). Our results demonstrate that pdgfra mutants have defects in cardiac morphology as a result of abnormal fusion of myocardial precursors. Expression analysis of the developing heart at later stages suggested that Pdgfra-mRFP is expressed in the endocardium. Further ...
Congenital heart disease (CHD) is a leading cause of mortality in children worldwide. According to the American Heart Association, Congenital cardiovascular defects are present in about one percent of live births and are the most common malformations in newborns. Researchers from the University of Pennsylvania School of Medicine have recently identified new signaling pathways that may lead to a better understanding of how this deadly disease forms. Jonathan Epstein, MD, Associate Professor of Medicine and the studys lead investigator, identified a receptor in endothelial cells (the cells that line blood vessels) that when interrupted in mice, results in CHD and defects in the growth and arrangement of blood vessels (patterning). "With the identification of this receptor, we hope to one day develop molecular medicines that will essentially steer developing blood vessels away from where they shouldnt go," said Epstein ...
Absent Inferior Vena Cava (IVC) is an uncommon but well recognised anomaly. Anomalies of the IVC have been described more frequently (0.6%-2%) in those with other cardiovascular defects [2], and less frequently in otherwise healthy individuals. Various anomalies of the IVC have been described including complete absence, partial absence or presence of bilateral IVC [3].. There is controversy as to whether an absent IVC is a true embryonic anomaly or whether it is the result of peri-natal IVC thrombosis causing regression and disappearance of the once present IVC [4].. There has been one previous report in the literature of an absent IVC and left renal hypoplasia- and a right hypertrophic kidney [5]; but a commoner association recognised is right renal aplasia [6] as suggested in a review by Gayer et al, where all nine patients with complete absence of the IVC had an absent or very small right kidney. The association of an absent or hypoplastic kidney is potentially related (or even the cause of ...
Noonan syndrome represents one of the most common dysmorphic disorders with an incidence between 1 in 1000 to 1 in 2500 live births. The most characteristic features of this syndrome are craniofacial dysmorphy, short stature, cardiovascular defects, bone and skeletal defects, as well as delayed puberty and cryptorchidism in males.
In the human, at Carnegie stage 14, the myocardial wall of the outflow tract extends to the border of the pericardial cavity where it joins the aortic sac, giving rise to the arteries that feed the pharyngeal arches [25].OFT remodeling is a process whereby the embryonic outflow tract undergoes a series of developmental transitions that involves extra cardiac cells recruitment and transformations that when disrupted, can result in Persistent Truncus Arteriosus (PTA), a rare congenital heart anomaly in humans. [13]. PTA occurs when there is a deficiency in the number of neural crest cells that reach the cardiac outflow tract, thus the truncus arteriosus will not be developed properly and will not be able to properly divide the common truncal outflow vessel into the pulmonary trunk and aorta, resulting in only a single arterial trunk arising from the heart [26]. This will cause the oxygenated and deoxygenated blood to be mixed and the mixed blood will be pumped through the coronary and pulmonary ...
Anatomic aortic anomalies are seen in many medical conditions and are known to cause disturbances in blood flow. Turner syndrome (TS) is a genetic disorder occurring only in females where cardiovascular anomalies, particularly of the aorta, are frequently encountered. In this study, numerical simulations are applied to investigate the flow characteristics in four TS patient- related aortic arches (a normal geometry, dilatation, coarctation and elongation of the transverse aorta). The Quemada viscosity model was applied to account for the non-Newtonian behavior of blood. The blood is treated as a mixture consisting of water and red blood cells (RBC) where the RBCs are modeled as a convected scalar. The results show clear geometry effects where the flow structures and RBC distribution are significantly different between the aortas. Transitional flow is observed as a jet is formed due to a constriction in the descending aorta for the coarctation case. RBC dilution is found to vary between the ...
Medical definition of DiGeorge syndrome: a rare congenital disease that is characterized especially by absent or underdeveloped thymus and parathyroid glands, heart defects, immunodeficiency, hypocalcemia, and characteristic facial features (as wide-set eyes, small jaws, and low-set ears) and is typically caused by a deletion on the chromosome numbered 22.
Ultrasound Obstet Gynecol 2010; 36: 553-555 Published online 2 September 2010 in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/uog.7711 Isolated …
Genetics is a powerful tool, especially when used in combination with embryology, in the seeking of genes necessary for assembly of the cardiovasculature. The first questions must address the types of cellular decisions that are made during development. As for simpler systems in C elegans and D melanogaster, the lineage and cell-fate decisions of the cardiovascular progenitors need to be assessed. In addition it is likely that new paradigms will emerge for multicellular assembly. The study of cardiovascular mutations will define individual genetic steps that define organotypic decisions. A genetic approach is a natural extension of embryology, physiology, and anatomy, fields of great sophistication with regard to the cardiovasculature, because, like them, it focuses on integrative biology and on the intact organism. The zebrafish is particularly well suited to a combination genetic-embryologic study of the fashioning of the cardiovasculature. ...
A 65-year-old man presented to our hospital with a chief complaint of hoarseness. Chest radiography and computed tomography detected a right subclavian artery aneurysm. The aneurysm had a maximum diameter of 85 mm, and was associated with a mural thrombus and displacement of the trachea to the left, which led to airway stenosis. In case ventilatory insufficiency developed during anesthesia induction, an extracorporeal membrane oxygenator was prepared, followed by administration of anesthesia. Careful administration of anesthesia allowed for anesthesia management without the extracorporeal membrane oxygenator. We approached the periphery and the proximal portion of the aneurysm through a right subclavicular incision and partial median sternotomy, respectively. After excision of the aneurysm, we performed EPTFE prosthesis implantation. The patient fs postoperative course was uneventful, which led to postoperative improvement of the airway stenosis. The combination of a right subclavicular incision ...
CONGENITAL anomalies of the great veins of the neck are relatively infrequent. Persistent left superior vena cava (PLSVC) is an embryologic remnant of the left superior cardinal vein seen in 0.1 to 0.3% of healthy adults.1 PLSVC runs between the left pulmonary veins and the left atrial appendage enlarging the coronary sinus as it enters the atrium. When present, it can affect placement of central catheters, pacemakers, and cardiopulmonary bypass. It is important to be aware of this variation and to recognize it in imaging studies ...
OBJECTIVES. Congenital cardiac defects (CCD) are the most common heart diseases in dogs of less than 1 year of age. The exact prevalence of CCD is uncertain as there are both national and regional differences for certain cardiovascular malformations. Because multiple congenital anomalies may be present in the same dog the chosen method of reporting defects will alter frequency data. The three most common CCD reported in dogs in USA and UK have been patent ductus arteriosus (PDA), (sub)aortic stenosis and pulmonic stenosis (PS). However, most recent reports indicate that subaortic stenosis (SAS) is the most common CCD in dogs in many regions of the world. The aim of this report is to characterize the prevalence of different types of CCD in a population of dogs in the south east of Spain. MATERIALS. This retrospective study was performed in 80 dogs presented between 1994 and 2001 to Veterinary Teaching Hospital of University of Murcia (Spain) and diagnosed with CCD. A complete information about ...
Obstructive sleep apnea is a significant medical problem affecting up to 4 percent of middle-aged adults. The most common complaints are loud snoring, disrupted sleep and excessive daytime sleepiness. Patients with apnea suffer from fragmented sleep and may develop cardiovascular abnormalities because of the repetitive cycles of snoring, airway collapse and arousal. Although most patients are overweight and have a short, thick neck, some are of normal weight but have a small, receding jaw. Because many patients are not aware of their heavy snoring and nocturnal arousals, obstructive sleep apnea may remain undiagnosed; therefore, it is helpful to question the bedroom partner of a patient with chronic sleepiness and fatigue. Polysomnography in a sleep laboratory is the gold standard for confirming the diagnosis of obstructive sleep apnea; however, the test is expensive and not widely available. Home sleep studies are less costly but not as diagnostically accurate. Treatments include weight loss, nasal

Arrhythmogenic Right Ventricular Cardiomyopathy - SNPediaArrhythmogenic Right Ventricular Cardiomyopathy - SNPedia

Standard genetic screening test are currently tested and evaluated in different state of the art cardiovascular research ... because this genetic abnormality can affect also the integrity of the superficial layers of the skin most exposed to pressure ...
more infohttps://www.snpedia.com/index.php/Arrhythmogenic_Right_Ventricular_Cardiomyopathy

Preparticipation screening for cardiovascular abnormalities in young competitive athletes | The BMJPreparticipation screening for cardiovascular abnormalities in young competitive athletes | The BMJ

Preparticipation screening for cardiovascular abnormalities in young competitive athletes BMJ 2008; 337 :a1596 ... Athletes with abnormalities on initial evaluation are investigated further and those with potentially serious abnormalities are ... Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive ... of which were eventually diagnosed as a cardiovascular abnormality. The investigators reported an electrocardiographic ...
more infohttps://www.bmj.com/content/337/bmj.a1596?ijkey=3a3024620df0f1e1666ccebef47d3c6206f923b3&keytype2=tf_ipsecsha

Vitamin D Does Not Reduce Cardiovascular Abnormalities in Kidney Disease PatientsVitamin D Does Not Reduce Cardiovascular Abnormalities in Kidney Disease Patients

Almost a years treatment with a vitamin D compound did not alleviate key structural and functional cardiovascular ... abnormalities in patients with kidney disease and cardiac enlargement. ... Vitamin D Does Not Reduce Cardiovascular Abnormalities in Kidney Disease Patients. by Thilaka Ravi on February 15, 2012 at 11: ... the current study was designed to investigate the impact of paricalcitol treatment on specific cardiovascular abnormalities. ...
more infohttps://www.medindia.net/news/vitamin-d-does-not-reduce-cardiovascular-abnormalities-in-kidney-disease-patients-97545-1.htm

Child Obesity Tied to Cardiovascular Abnormalities - MPRChild Obesity Tied to Cardiovascular Abnormalities - MPR

Child obesity often is accompanied by cardiovascular abnormalities, and early detection and prevention programs are needed to ... HealthDay News) - Child obesity often is accompanied by cardiovascular abnormalities, and early detection and prevention ... obese children may show early signs of cardiovascular dysfunction. Some of the abnormalities detected in obese children and ... and colleagues reviewed the literature to summarize current research on cardiovascular abnormalities in children with obesity. ...
more infohttps://www.empr.com/medical-news/child-obesity-tied-to-cardiovascular-abnormalities/article/307451/

JCI -
Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivityJCI - Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity

... and other cardiovascular abnormalities. There is currently no targeted therapy, and it is unknown whether cardiovascular ... Cardiovascular abnormalities in CS result from KATP channel GoF in VSM cells. To directly test whether cardiac remodeling ... Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity. Conor McClenaghan,1, ... There are currently no targeted therapies for CS and it is not known if, or to what extent, cardiovascular abnormalities can be ...
more infohttps://www.jci.org/articles/view/130571

Cardiovascular Abnormalities Seen in Treatment-Naive RA Patients - The RheumatologistCardiovascular Abnormalities Seen in Treatment-Naive RA Patients - The Rheumatologist

Cardiovascular Abnormalities Seen in Treatment-Naive RA Patients. Cardiovascular Abnormalities Seen in Treatment-Naive RA ... SLE Patients May Not Receive Enough Cardiovascular Disease Assessment & Treatment. * Patients with Large-Vessel Abnormalities ... SLE Patients May Not Receive Enough Cardiovascular Disease Assessment & Treatment. *Patients with Large-Vessel Abnormalities ... "In early RA patients such as those investigated in our study, the presence of abnormalities and impact of DMARD has not been ...
more infohttps://www.the-rheumatologist.org/article/cardiovascular-abnormalities-seen-in-treatment-naive-ra-patients/

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14:...Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14:...

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14: ... Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 14: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14: ...
more infohttp://circ.ahajournals.org/content/132/22/e343

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9:...Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9:...

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ...
more infohttp://circ.ahajournals.org/content/early/2015/11/02/CIR.0000000000000245

Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy | Lurie ChildrensCardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy | Lurie Children's

... and there were no cardiovascular safety concerns. The cardiovascular abnormalities identified may be related to Pompe disease ... Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy. Forsha, D.; Li, J. S.; ... Baseline cardiovascular abnormalities, and efficacy and safety of enzyme replacement therapy were described. Three pediatric ... PURPOSE: We evaluated the prevalence of cardiovascular abnormalities and the efficacy and safety of enzyme replacement therapy ...
more infohttps://www.luriechildrens.org/en/research/publications/cardiovascular-abnormalities-in-late-onset-pompe-disease-and-response-to-enzyme-replacement-therapy/

Cardiovascular abnormalities in Downs syndrome: spectrum, management and survival over 22 years | Archives of Disease in...Cardiovascular abnormalities in Down's syndrome: spectrum, management and survival over 22 years | Archives of Disease in...

Adults with genetic syndromes and cardiovascular abnormalities: clinical history and management. Genet Med 2008;10:469-94. ... It remains the commonest chromosomal abnormality in live born infants1 and its association with cardiovascular anomalies is ... Cardiovascular abnormalities in Downs syndrome: spectrum, management and survival over 22 years ... Cardiovascular abnormalities in Downs syndrome: spectrum, management and survival over 22 years ...
more infohttp://adc.bmj.com/content/97/4/326.full

May the best friend be an enemy if not recognized early: possible role of omega-3 against cardiovascular abnormalities due...May the best friend be an enemy if not recognized early: possible role of omega-3 against cardiovascular abnormalities due...

May the best friend be an enemy if not recognized early: possible role of omega-3 against cardiovascular abnormalities due ... ATYPICAL ANTIPSYCHOTICS DRUGS, AUTISM AND CARDIOVASCULAR ABNORMALITIES. Antipsychotic therapy has become indispensable in the ... Pode um melhor amigo ser um inimigo se não reconhecido a tempo: possível papel do ômega-3 nos efeitos cardiovasculares ... OMEGA-3 AND CARDIOVASCULAR SYSTEM: ANTIARRHYTHMIC PROPERTIES AND PREVENTION OF SUDDEN CARDIAC DEATH ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000500031&lng=en&nrm=iso

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 11:...Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 11:...

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 11: ... Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 11: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 11: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 11: ...
more infohttp://www.onlinejacc.org/content/66/21/2429

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9:...Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9:...

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ... Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 9: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: ...
more infohttp://www.onlinejacc.org/content/66/21/2412

FAQ • Cardiovascular AbnormalitiesFAQ • Cardiovascular Abnormalities

Cardiovascular Abnormalities. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several ... FAQ - Cardiovascular Abnormalities. (Powered by Yahoo! Answers). Does a cardiovascular based workout work the best for weight ... What cardiovascular exercises to do in the winter?. I was wondering what can I do in the Winter to keep my cardiovascular ... 2. 1 out of 150 babies is born with a chromosomal abnormality. These types of abnormalities occur when the structure of a ...
more infohttps://lookfordiagnosis.com/faq.php?term=Cardiovascular+Abnormalities&lang=1

View source for Template:Cardiovascular abnormalities - EmbryologyView source for Template:Cardiovascular abnormalities - Embryology

Cardiovascular System - Abnormalities,cardiovascular abnormalities]],noinclude>[[Category:Template]][[Category:Term Link]][[ ... Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Template:Cardiovascular_abnormalities ... View source for Template:Cardiovascular abnormalities. From Embryology. ← Template:Cardiovascular abnormalities. Jump to: ...
more infohttps://embryology.med.unsw.edu.au/embryology/index.php?title=Template:Cardiovascular_abnormalities&action=edit

Subclinical cardiovascular abnormalities in patients with juvenile systemic lupus erythematosus | Pediatric Rheumatology | Full...Subclinical cardiovascular abnormalities in patients with juvenile systemic lupus erythematosus | Pediatric Rheumatology | Full...

We conclude that early identification of subclinical cardiovascular abnormalities is important to reduce overt cardiovascular ... Subclinical cardiovascular abnormalities in patients with juvenile systemic lupus erythematosus. *Nur Canpolat, ... The aim of this study is to evaluate subclinical cardiovascular abnormalities including atherosclerosis and left ventricular ... Non-invasive cardiovascular assessments were made on 22 patients with juvenile SLE (20 girls, aged 15.0 ± 2.7 years) with GFR ≥ ...
more infohttps://ped-rheum.biomedcentral.com/articles/10.1186/1546-0096-9-S1-O20

Effects of bone marrow transplantation on the cardiovascular abnormalities in canine mucopolysaccharidosis VII - Semantic...Effects of bone marrow transplantation on the cardiovascular abnormalities in canine mucopolysaccharidosis VII - Semantic...

In three MPS VII dogs that received heterologous BMT at 6 weeks of age, the echocardiographic abnormalities were improved, and ... Echocardiographic abnormalities in dogs with MPS type VII (Sly syndrome, β-glucuronidase deficiency) included mitral valve ... Clinical characterization of cardiovascular abnormalities associated with feline mucopolysaccharidosis I and VI. Meg M. Sleeper ... Effects of bone marrow transplantation on the cardiovascular abnormalities in canine mucopolysaccharidosis VII. @article{ ...
more infohttps://www.semanticscholar.org/paper/Effects-of-bone-marrow-transplantation-on-the-in-Sammarco-Weil/2fc9c9c1b648631ee9afe2a8264e5356beb76841

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 3:...Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 3:...

... cardiovascular abnormalities, cardiovascular magnetic resonance, hypertrophic cardiomyopathy, myocarditis, sudden death",. ... T1 - Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities. T2 - Task ... Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 3: ... Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 3: ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/eligibility-and-disqualification-recommendations-for-competitive--3

Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management | Bentham ScienceSitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management | Bentham Science

Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management. Author(s): Jose ... Title:Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management. VOLUME: 26 ... Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management", Current Medicinal Chemistry (2019) 26: 6766 ... Hematological abnormalities (hemolytic anemia and macrothrombocytopenia) may be present in 25-35% of patients, in whom it is ...
more infohttp://www.eurekaselect.com/163557/article

Polycystic kidney disease (PKD): Vascular abnormalities - Cardiovascular Molecular Imaging Lab: Martin G. Rodriguez-Porcel -...Polycystic kidney disease (PKD): Vascular abnormalities - Cardiovascular Molecular Imaging Lab: Martin G. Rodriguez-Porcel -...

... at Mayo Clinic is investigating the vascular abnormalities in PKD. ... The Cardiovascular Molecular Imaging Lab of Martin G. Rodriguez-Porcel, M.D., ... Polycystic kidney disease (PKD): Vascular abnormalities. The overall aim of the Cardiovascular Molecular Imaging Laboratorys ... to verify the hypothesis that vascular abnormalities are a primary problem in PKD. ...
more infohttp://www.mayo.edu/research/labs/cardiovascular-molecular-imaging/research/polycystic-kidney-disease-pkd

Karyotypic and Molecular Genetic Changes Associated With Fetal Cardiovascular Abnormalities: Results of a Retrospective 4-Year...Karyotypic and Molecular Genetic Changes Associated With Fetal Cardiovascular Abnormalities: Results of a Retrospective 4-Year...

2. Poprawski K, Michalski M, Lawniczak M, Lacka K. Cardiovascular abnormalities in patients with Turner syndrome according to ... Karyotypic and Molecular Genetic Changes Associated With Fetal Cardiovascular Abnormalities: Results of a Retrospective 4-Year ... Karyotypic and Molecular Genetic Changes Associated With Fetal Cardiovascular Abnormalities: Results of a Retrospective 4-Year ... Drug Discovery Today: Disease Mechanisms / Cardiovascular diseases. 2004;1:1-8 26. Nath AK, Krauthammer M, Li P. et al. ...
more infohttp://www.ijbs.com/v09p0463.htm

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble,...Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble,...

ACC/AHA Scientific Statements; athletes; cardiovascular abnormalities; genetics; hypertrophic cardiomyopathy; sudden death ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, ... Cardiovascular Abnormalities/complications. *Cardiovascular Abnormalities/epidemiology*. *Cardiovascular Abnormalities/therapy* ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=phg&id=5423

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble,...Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble,...

ACC/AHA Scientific Statements; athletes; cardiovascular abnormalities; genetics; hypertrophic cardiomyopathy; sudden death ... Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, ... Cardiovascular Abnormalities/complications. *Cardiovascular Abnormalities/epidemiology*. *Cardiovascular Abnormalities/therapy* ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=tier&id=1420

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 4:...Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 4:...

T1 - Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities. T2 - Task ... Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 4: ... keywords = "ACC/AHA Scientific Statements, athletes, cardiovascular abnormalities, congenital heart disease, coronary vessel ... Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 4: ...
more infohttps://indiana.pure.elsevier.com/en/publications/eligibility-and-disqualification-recommendations-for-competitive--32
  • Quite interesting, substantial evidence from epidemiological and case-control studies indicates that omega-3 reduces the risk of cardiovascular mortality, particularly sudden cardiac death. (scielo.br)
  • In accordance to the above mentioned findings, as omega-3 fatty acids per se have a direct cardiovascular protective role, our paper hypothesized that omega-3 fatty acids supplementation in ASD patients treated with atypical antipsychotic drugs may reduce cardiac arrhythmias and hence sudden cardiac death. (scielo.br)
  • Bao B, Wang Y, Hu H, Yao H, Li Y, Tang S, Zheng L, Xu Y, Liang Z. Karyotypic and Molecular Genetic Changes Associated With Fetal Cardiovascular Abnormalities: Results of a Retrospective 4-Year Ultrasonic Diagnosis Study. (ijbs.com)
  • Therefore, the present study examined the value of repolarization abnormalities on the ECG, as characterized by STD and a prolonged rate-corrected QT interval (QTc), and repolarization complexity, as measured by the PCA ratio, for prediction of CV and all-cause mortality in adults with diabetes. (diabetesjournals.org)
  • Following this reasoning, emerging data indicate that some antipsychotics may be associated with cardiovascular adverse events (e.g. (scielo.br)
  • HealthDay News) - Child obesity often is accompanied by cardiovascular abnormalities , and early detection and prevention programs are needed to avoid progressive damage at an early age, according to research published online Aug. 14 in the Journal of the American College of Cardiology . (empr.com)
  • The researchers found that, independent of other obesity-related comorbid conditions, such as dyslipidemia and insulin resistance, obese children may show early signs of cardiovascular dysfunction. (empr.com)
  • Anita T. Cote, PhD, of the University of British Columbia in Vancouver, Canada, and colleagues reviewed the literature to summarize current research on cardiovascular abnormalities in children with obesity. (empr.com)
  • I've had 3 children with no abnormalities. (lookfordiagnosis.com)
  • Lists four common valvular abnormalities for the left side of the heart and describes the alterations in intracardiac and arterial pressures, flow patterns, and heart sounds that accompany them. (mhmedical.com)